JP7090604B2 - びまん性大細胞型b細胞リンパ腫の予後予測因子、及び予後予測方法 - Google Patents
びまん性大細胞型b細胞リンパ腫の予後予測因子、及び予後予測方法 Download PDFInfo
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- JP7090604B2 JP7090604B2 JP2019518738A JP2019518738A JP7090604B2 JP 7090604 B2 JP7090604 B2 JP 7090604B2 JP 2019518738 A JP2019518738 A JP 2019518738A JP 2019518738 A JP2019518738 A JP 2019518738A JP 7090604 B2 JP7090604 B2 JP 7090604B2
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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Description
(1)DLBCLの予後予測検査方法であって、TP53及び/又はOSBPL10の変異を検出することを特徴とする検査方法。
(2)一方のアリルにTP53の変異が、他方のアリルに17p欠損が併存している場合に、予後不良であるとする(1)記載の検査方法。
(3)OSBPL10の変異を有する場合に、予後良好であるとする(1)記載の検査方法。
(4)DLBCLの予後予測因子であって、一方のアリルにTP53の変異が存在し、他方のアリルの17p欠損が併存していること、及び/又はOSBPL10の変異であることを特徴とする予後予測因子。
(5)(4)記載のDLBCLの予後予測因子を検出するための検出試薬を含む検出キット。
F:ATCACTGGGTTCGCTGAAGG(配列番号1)
R:CATTTCCCGGGGATTTGGAG(配列番号2)
TP53
F1:AGAGGAGCTGGTGTTGTTGG(配列番号3)
R1:TTGGGAGTAGATGGAGCCTG(配列番号4)
F2:GCCAGAGAAAAGAAAACTGAGTG(配列番号5)
R2:CCCCATGAGATGTGCAAAGT(配列番号6)
F3:ATTTACTTTGCACATCTCATGGG(配列番号7)
R3:CACTTGTGCCCTGACTTTCA(配列番号8)
なお、Fはフォワードプライマーを、Rはリバースプライマーを示し、TP53のシーケンスは、1~3の3組のプライマーを用いて行った。
Claims (4)
- びまん性大細胞型B細胞リンパ腫(DLBCL)の予後予測検査方法であって、
TP53の変異を検出し、
一方のアリルにTP53の変異が、
他方のアリルに17p欠損が併存している場合に予後不良であるとすることを特徴とする検査方法。 - DLBCLの予後予測検査方法であって、
OSBPL10の変異を検出し、
OSBPL10の変異を有する場合に予後良好であるとする検査方法。 - DLBCLの予後予測検査方法であって、
請求項1及び2記載の検査方法によって予後予測することを特徴とする予後予測検査方法。 - DLBCLの予後を予測するための検査キットであって、
TP53の変異及び17p欠損を検出するための試薬、並びに/又はOSBPL10の変異を検出するための検出試薬を含む検査キット。
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JP2017097943 | 2017-05-17 | ||
JP2017097943 | 2017-05-17 | ||
PCT/JP2018/018165 WO2018212071A1 (ja) | 2017-05-17 | 2018-05-10 | びまん性大細胞型b細胞リンパ腫の予後予測因子、及び予後予測方法 |
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JPWO2018212071A1 JPWO2018212071A1 (ja) | 2020-03-19 |
JP7090604B2 true JP7090604B2 (ja) | 2022-06-24 |
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CN111584001B (zh) * | 2020-02-13 | 2022-05-20 | 上海交通大学医学院附属瑞金医院 | 一种用于淋巴瘤预后判断的方法、试剂盒及应用 |
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- 2018-05-10 JP JP2019518738A patent/JP7090604B2/ja active Active
Non-Patent Citations (8)
Title |
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Blood, 2012, Vol.120, No.19, p.3986-3996 |
Blood, 2017.12.07, Vol.130, No.Suppl 1, Article.1464 [online], [retrieved on 2018.07.18], Retrieved |
Hypertens. Res., 2010, Vol.33, No.5, p.511-514 |
Oncotarget. 2018.04.13, Vol.9, No.28, p.19555-19568 |
日本リンパ網内系学会会誌, 2017.05.30, Vol.57, p.87(O-4) |
日本リンパ網内系学会会誌, 2017.05.30, Vol.57, p.97(P5-3) |
日本臨牀, 2015, Vol.73, No.増刊号8, p.149-153 |
病理と臨床, 2015, Vol.33, No.5, p.512-516 |
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WO2018212071A1 (ja) | 2018-11-22 |
JPWO2018212071A1 (ja) | 2020-03-19 |
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