JP7073530B2 - 拡張可能遠位領域を有する血管内ポンプ - Google Patents

拡張可能遠位領域を有する血管内ポンプ Download PDF

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Publication number
JP7073530B2
JP7073530B2 JP2020558013A JP2020558013A JP7073530B2 JP 7073530 B2 JP7073530 B2 JP 7073530B2 JP 2020558013 A JP2020558013 A JP 2020558013A JP 2020558013 A JP2020558013 A JP 2020558013A JP 7073530 B2 JP7073530 B2 JP 7073530B2
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Japan
Prior art keywords
foldable
expandable
blood pump
expandable region
region
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JP2020558013A
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English (en)
Japanese (ja)
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JP2021521934A (ja
JP2021521934A5 (enExample
Inventor
カンブロンヌ,マシュー・ディ
ヒギンス,ジョセフ・ピィ
ハセルマン,ベンジャミン・ディ
バン・デ・ムールテレ,トリスタン・エイ
ティルストラ,マシュー・ダブリュ
ストーン,ジェフリー・アール
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Cardiovascular Systems Inc
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Cardiovascular Systems Inc
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Publication of JP2021521934A5 publication Critical patent/JP2021521934A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80Constructional details other than related to driving
    • A61M60/855Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/857Implantable blood tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10Location thereof with respect to the patient's body
    • A61M60/122Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/13Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10Location thereof with respect to the patient's body
    • A61M60/122Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10Location thereof with respect to the patient's body
    • A61M60/122Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/165Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
    • A61M60/17Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart inside a ventricle, e.g. intraventricular balloon pumps
    • A61M60/174Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart inside a ventricle, e.g. intraventricular balloon pumps discharging the blood to the ventricle or arterial system via a cannula internal to the ventricle or arterial system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20Type thereof
    • A61M60/205Non-positive displacement blood pumps
    • A61M60/216Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40Details relating to driving
    • A61M60/403Details relating to driving for non-positive displacement blood pumps
    • A61M60/408Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
    • A61M60/411Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40Details relating to driving
    • A61M60/403Details relating to driving for non-positive displacement blood pumps
    • A61M60/422Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80Constructional details other than related to driving
    • A61M60/802Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/81Pump housings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80Constructional details other than related to driving
    • A61M60/855Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/865Devices for guiding or inserting pumps or pumping devices into the patient's body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0266Shape memory materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40Details relating to driving
    • A61M60/403Details relating to driving for non-positive displacement blood pumps
    • A61M60/408Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
    • A61M60/411Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
    • A61M60/414Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40Details relating to driving
    • A61M60/403Details relating to driving for non-positive displacement blood pumps
    • A61M60/408Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
    • A61M60/411Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
    • A61M60/416Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted directly by the motor rotor drive shaft

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • External Artificial Organs (AREA)
  • Transplantation (AREA)
JP2020558013A 2018-04-20 2019-04-19 拡張可能遠位領域を有する血管内ポンプ Active JP7073530B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862660511P 2018-04-20 2018-04-20
US201862660538P 2018-04-20 2018-04-20
US62/660,538 2018-04-20
US62/660,511 2018-04-20
US16/388,362 2019-04-18
US16/388,362 US11110264B2 (en) 2018-04-20 2019-04-18 Intravascular pump with expandable distal region
PCT/US2019/028262 WO2019204689A1 (en) 2018-04-20 2019-04-19 Intravascular pump with expandable distal region

Publications (3)

Publication Number Publication Date
JP2021521934A JP2021521934A (ja) 2021-08-30
JP2021521934A5 JP2021521934A5 (enExample) 2021-11-18
JP7073530B2 true JP7073530B2 (ja) 2022-05-23

Family

ID=68236228

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020558013A Active JP7073530B2 (ja) 2018-04-20 2019-04-19 拡張可能遠位領域を有する血管内ポンプ

Country Status (5)

Country Link
US (1) US11110264B2 (enExample)
EP (1) EP3781225B1 (enExample)
JP (1) JP7073530B2 (enExample)
CN (1) CN112004564A (enExample)
WO (1) WO2019204689A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115040776A (zh) 2016-10-25 2022-09-13 马真塔医药有限公司 心室辅助装置
US12029647B2 (en) 2017-03-07 2024-07-09 4C Medical Technologies, Inc. Systems, methods and devices for prosthetic heart valve with single valve leaflet
US12036113B2 (en) 2017-06-14 2024-07-16 4C Medical Technologies, Inc. Delivery of heart chamber prosthetic valve implant
CN115177858A (zh) 2018-01-10 2022-10-14 马真塔医药有限公司 心室辅助装置
US10905808B2 (en) 2018-01-10 2021-02-02 Magenta Medical Ltd. Drive cable for use with a blood pump
US20190365538A1 (en) * 2018-06-04 2019-12-05 4C Medical Technologies, Inc. Devices, systems and methods for preventing prolapse of native cardiac valve leaflets
US11219753B2 (en) * 2018-07-30 2022-01-11 Cardiovascular Systems, Inc. Intravascular pump with expandable and collapsible inlet region and methods thereof
US11857441B2 (en) 2018-09-04 2024-01-02 4C Medical Technologies, Inc. Stent loading device
EP3782666B1 (en) 2019-01-24 2021-08-11 Magenta Medical Ltd. Manufacturing an impeller
US11452628B2 (en) 2019-04-15 2022-09-27 4C Medical Technologies, Inc. Loading systems for collapsible prosthetic heart valve devices and methods thereof
KR20220129582A (ko) * 2020-01-14 2022-09-23 아비오메드, 인크. 유출 호스를 가진 혈관내 혈액 펌프
US12133797B2 (en) 2020-01-31 2024-11-05 4C Medical Technologies, Inc. Prosthetic heart valve delivery system: paddle attachment feature
US11931253B2 (en) 2020-01-31 2024-03-19 4C Medical Technologies, Inc. Prosthetic heart valve delivery system: ball-slide attachment
US12053375B2 (en) 2020-03-05 2024-08-06 4C Medical Technologies, Inc. Prosthetic mitral valve with improved atrial and/or annular apposition and paravalvular leakage mitigation
US11992403B2 (en) 2020-03-06 2024-05-28 4C Medical Technologies, Inc. Devices, systems and methods for improving recapture of prosthetic heart valve device with stent frame having valve support with inwardly stent cells
WO2021205346A2 (en) 2020-04-07 2021-10-14 Magenta Medical Ltd Ventricular assist device
WO2022076862A1 (en) * 2020-10-08 2022-04-14 Shifamed Holdings, Llc Intravascular blood pumps and methods of use
CN114642827A (zh) * 2020-12-17 2022-06-21 苏州心岭迈德医疗科技有限公司 心室辅助泵血器械及系统
US20230248960A1 (en) * 2020-12-22 2023-08-10 Boston Scientific Scimed Inc. Constraint Delivery – Hinge & Constraint Delivery - Corset
WO2022140635A1 (en) * 2020-12-23 2022-06-30 Boston Scientific Scimed Inc. Facilitate delivery of devices with high friction - braid
US20230201560A1 (en) * 2021-12-29 2023-06-29 Tc1 Llc Guidewire configurations for implantable medical devices
CN114259645B (zh) * 2022-01-11 2024-12-06 丰凯利医疗器械(上海)有限公司 泵血装置
CN120053873A (zh) * 2025-03-19 2025-05-30 深圳核心医疗科技股份有限公司 血泵

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040044266A1 (en) 2000-12-01 2004-03-04 Thorsten Siess Intravascular pump
US20080262337A1 (en) 2004-05-17 2008-10-23 C.R. Bard, Inc. Method and Apparatus for Mapping and/or Ablation of Cardiac Tissue
US20110004046A1 (en) 2009-07-01 2011-01-06 The Penn State Research Foundation Blood pump with expandable cannula
JP2021510318A (ja) 2018-01-10 2021-04-22 マジェンタ・メディカル・リミテッド 心室補助デバイス

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625712A (en) 1983-09-28 1986-12-02 Nimbus, Inc. High-capacity intravascular blood pump utilizing percutaneous access
US4969458A (en) 1987-07-06 1990-11-13 Medtronic, Inc. Intracoronary stent and method of simultaneous angioplasty and stent implant
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US5019090A (en) 1988-09-01 1991-05-28 Corvita Corporation Radially expandable endoprosthesis and the like
US4964864A (en) 1988-09-27 1990-10-23 American Biomed, Inc. Heart assist pump
US4950227A (en) 1988-11-07 1990-08-21 Boston Scientific Corporation Stent delivery system
US4856516A (en) 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
JPH0636821B2 (ja) 1990-03-08 1994-05-18 健二 山崎 体内埋設形の補助人工心臓
US5161547A (en) 1990-11-28 1992-11-10 Numed, Inc. Method of forming an intravascular radially expandable stent
US5314472A (en) 1991-10-01 1994-05-24 Cook Incorporated Vascular stent
US5776183A (en) 1996-08-23 1998-07-07 Kanesaka; Nozomu Expandable stent
DE19821307C1 (de) 1998-05-13 1999-10-21 Impella Cardiotech Gmbh Intrakardiale Blutpumpe
US7393181B2 (en) 2004-09-17 2008-07-01 The Penn State Research Foundation Expandable impeller pump
US20080132748A1 (en) * 2006-12-01 2008-06-05 Medical Value Partners, Llc Method for Deployment of a Medical Device
US9028392B2 (en) 2006-12-01 2015-05-12 NuCardia, Inc. Medical device
US9232992B2 (en) * 2008-07-24 2016-01-12 Aga Medical Corporation Multi-layered medical device for treating a target site and associated method
WO2011035327A1 (en) * 2009-09-21 2011-03-24 Medtronic Inc. Stented transcatheter prosthetic heart valve delivery system and method
US8849398B2 (en) 2011-08-29 2014-09-30 Minnetronix, Inc. Expandable blood pump for cardiac support
US9585991B2 (en) * 2012-10-16 2017-03-07 Heartware, Inc. Devices, systems, and methods for facilitating flow from the heart to a blood pump
US20140200395A1 (en) * 2012-12-11 2014-07-17 Bilal Shafi Apparatuses and methods for preventing or reversing heart dilation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040044266A1 (en) 2000-12-01 2004-03-04 Thorsten Siess Intravascular pump
US20080262337A1 (en) 2004-05-17 2008-10-23 C.R. Bard, Inc. Method and Apparatus for Mapping and/or Ablation of Cardiac Tissue
US20110004046A1 (en) 2009-07-01 2011-01-06 The Penn State Research Foundation Blood pump with expandable cannula
JP2021510318A (ja) 2018-01-10 2021-04-22 マジェンタ・メディカル・リミテッド 心室補助デバイス

Also Published As

Publication number Publication date
CN112004564A (zh) 2020-11-27
WO2019204689A1 (en) 2019-10-24
JP2021521934A (ja) 2021-08-30
US20190321530A1 (en) 2019-10-24
EP3781225B1 (en) 2023-04-19
US11110264B2 (en) 2021-09-07
EP3781225A1 (en) 2021-02-24
EP3781225A4 (en) 2022-02-23

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