JP7058264B2 - 血管内光干渉断層撮影法を用いた冠動脈プラークの自動特徴分析およびリスク評価のためのシステムおよび方法 - Google Patents

血管内光干渉断層撮影法を用いた冠動脈プラークの自動特徴分析およびリスク評価のためのシステムおよび方法 Download PDF

Info

Publication number
JP7058264B2
JP7058264B2 JP2019516914A JP2019516914A JP7058264B2 JP 7058264 B2 JP7058264 B2 JP 7058264B2 JP 2019516914 A JP2019516914 A JP 2019516914A JP 2019516914 A JP2019516914 A JP 2019516914A JP 7058264 B2 JP7058264 B2 JP 7058264B2
Authority
JP
Japan
Prior art keywords
plaque
tissue
features
image
neural network
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2019516914A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019518581A (ja
JP2019518581A5 (https=
Inventor
トーマス イー ミルナー
ヴィクラム ラル バルアー
アイディン ザヘディヴァス
オースティン マッケルロイ
マーク ディー フェルドマン
テイラー ブレント ホイト
Original Assignee
リサーチ ディヴェロプメント ファウンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by リサーチ ディヴェロプメント ファウンデーション filed Critical リサーチ ディヴェロプメント ファウンデーション
Publication of JP2019518581A publication Critical patent/JP2019518581A/ja
Publication of JP2019518581A5 publication Critical patent/JP2019518581A5/ja
Priority to JP2022064872A priority Critical patent/JP7383070B2/ja
Application granted granted Critical
Publication of JP7058264B2 publication Critical patent/JP7058264B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G06T7/0014—Biomedical image inspection using an image reference approach
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/40—Analysis of texture
    • G06T7/41—Analysis of texture based on statistical description of texture
    • G06T7/45—Analysis of texture based on statistical description of texture using co-occurrence matrix computation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • A61B5/7267—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems involving training the classification device
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10101—Optical tomography; Optical coherence tomography [OCT]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20076—Probabilistic image processing
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20081—Training; Learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20084—Artificial neural networks [ANN]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30101—Blood vessel; Artery; Vein; Vascular
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Theoretical Computer Science (AREA)
  • Artificial Intelligence (AREA)
  • General Physics & Mathematics (AREA)
  • Evolutionary Computation (AREA)
  • Mathematical Physics (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Fuzzy Systems (AREA)
  • Quality & Reliability (AREA)
  • Optics & Photonics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Data Mining & Analysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Probability & Statistics with Applications (AREA)
  • Computing Systems (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2019516914A 2016-06-08 2017-06-08 血管内光干渉断層撮影法を用いた冠動脈プラークの自動特徴分析およびリスク評価のためのシステムおよび方法 Expired - Fee Related JP7058264B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022064872A JP7383070B2 (ja) 2016-06-08 2022-04-11 血管内光干渉断層撮影法を用いた冠動脈プラークの自動特徴分析およびリスク評価のためのシステムおよび方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662347379P 2016-06-08 2016-06-08
US62/347,379 2016-06-08
PCT/US2017/036587 WO2017214421A1 (en) 2016-06-08 2017-06-08 Systems and methods for automated coronary plaque characterization and risk assessment using intravascular optical coherence tomography

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022064872A Division JP7383070B2 (ja) 2016-06-08 2022-04-11 血管内光干渉断層撮影法を用いた冠動脈プラークの自動特徴分析およびリスク評価のためのシステムおよび方法

Publications (3)

Publication Number Publication Date
JP2019518581A JP2019518581A (ja) 2019-07-04
JP2019518581A5 JP2019518581A5 (https=) 2020-07-16
JP7058264B2 true JP7058264B2 (ja) 2022-04-21

Family

ID=60578977

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019516914A Expired - Fee Related JP7058264B2 (ja) 2016-06-08 2017-06-08 血管内光干渉断層撮影法を用いた冠動脈プラークの自動特徴分析およびリスク評価のためのシステムおよび方法
JP2022064872A Active JP7383070B2 (ja) 2016-06-08 2022-04-11 血管内光干渉断層撮影法を用いた冠動脈プラークの自動特徴分析およびリスク評価のためのシステムおよび方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022064872A Active JP7383070B2 (ja) 2016-06-08 2022-04-11 血管内光干渉断層撮影法を用いた冠動脈プラークの自動特徴分析およびリスク評価のためのシステムおよび方法

Country Status (7)

Country Link
US (1) US12213810B2 (https=)
EP (1) EP3468453B1 (https=)
JP (2) JP7058264B2 (https=)
KR (1) KR102531819B1 (https=)
AU (1) AU2017277784B2 (https=)
CA (1) CA3026650A1 (https=)
WO (1) WO2017214421A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107945176B (zh) * 2017-12-15 2021-05-11 西安中科微光影像技术有限公司 一种彩色ivoct成像方法
CN108171702A (zh) * 2018-01-18 2018-06-15 平安科技（深圳）有限公司 易损斑块识别方法、应用服务器及计算机可读存储介质
CN108416769B (zh) * 2018-03-02 2021-06-04 成都斯斐德科技有限公司 基于预处理的ivoct图像易损斑块自动检测方法
WO2019170561A1 (en) * 2018-03-08 2019-09-12 Koninklijke Philips N.V. Resolving and steering decision foci in machine learning-based vascular imaging
US11779220B2 (en) 2018-12-14 2023-10-10 Research Development Foundation Multi-channel orthogonal convolutional neural networks
CN119762473A (zh) 2019-01-13 2025-04-04 光实验成像公司 用于动脉图像区域及其特征的分类的系统和方法
GB201906103D0 (en) 2019-05-01 2019-06-12 Cambridge Entpr Ltd Method and apparatus for analysing intracoronary images
WO2021026224A1 (en) * 2019-08-05 2021-02-11 Lightlab Imaging, Inc. Longitudinal display of coronary artery calcium burden
KR102261111B1 (ko) * 2019-09-10 2021-06-04 인하대학교 산학협력단 Gan을 이용한 의료 영상의 광강도 분포 일반화 기법
WO2021199967A1 (ja) * 2020-03-30 2021-10-07 テルモ株式会社 プログラム、情報処理方法、学習モデルの生成方法、学習モデルの再学習方法、および、情報処理システム
WO2021206170A1 (ja) * 2020-04-10 2021-10-14 公益財団法人がん研究会 画像診断装置、画像診断方法、画像診断プログラムおよび学習済みモデル
JP7667852B2 (ja) * 2020-08-06 2025-04-23 キヤノン ユーエスエイ，インコーポレイテッド カテーテルベースのマルチモーダル画像における潜在的な偽陽性及び盲点の位置を特定するためのシステム及び方法
CN114792374A (zh) * 2021-01-23 2022-07-26 富泰华工业（深圳）有限公司 基于纹理分类的图像识别方法、电子装置及存储介质
CN112957012B (zh) * 2021-02-01 2022-09-30 浙江省医疗器械检验研究院 一种光学干涉断层成像系统轴向分辨率测量装置及测量方法
WO2022202320A1 (ja) * 2021-03-25 2022-09-29 テルモ株式会社 プログラム、情報処理方法及び情報処理装置
EP4195215A1 (en) * 2021-12-08 2023-06-14 Koninklijke Philips N.V. Thrombus treatment metric
KR102656944B1 (ko) * 2021-12-21 2024-04-16 주식회사 레이와트 기계 학습 기반의 분획혈류예비력 예측 방법
EP4361941A1 (en) * 2022-10-27 2024-05-01 Carl Zeiss Meditec AG Method, processor unit and system for processing of images
CN115436239B (zh) * 2022-11-07 2023-02-07 四川亿欣新材料有限公司 一种碳酸钙颗粒度检测方法
JP2026052353A (ja) * 2024-09-11 2026-03-24 国立研究開発法人国立循環器病研究センター 粥腫のリスクを判定するための方法、装置及びプログラム

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011521747A (ja) 2008-06-02 2011-07-28 ライトラブ イメージング， インコーポレイテッド 光コヒーレンストモグラフィ画像から組織特徴を取得する定量的方法
JP2013532295A (ja) 2010-07-09 2013-08-15 ソマロジック・インコーポレーテッド 肺癌バイオマーカーとその使用
JP2016515032A (ja) 2013-03-14 2016-05-26 リサーチ ディベロップメント ファウンデーション 光コヒーレンス断層撮影および二光子発光撮像のための装置および方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6141437A (en) * 1995-11-22 2000-10-31 Arch Development Corporation CAD method, computer and storage medium for automated detection of lung nodules in digital chest images
US5995651A (en) * 1996-07-11 1999-11-30 Duke University Image content classification methods, systems and computer programs using texture patterns
WO2002088705A2 (en) 2001-05-01 2002-11-07 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
US7075658B2 (en) * 2003-01-24 2006-07-11 Duke University Method for optical coherence tomography imaging with molecular contrast
DE102005010076A1 (de) * 2005-03-04 2006-09-07 Siemens Ag Bildbearbeitungsverfahren für ein digitales medizinisches Untersuchungsbild und zugehörige Untersuchungseinrichtung
WO2010105197A2 (en) * 2009-03-12 2010-09-16 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measuring at least one mechanical property of tissue using coherent speckle techniques(s)
US20120163693A1 (en) * 2010-04-20 2012-06-28 Suri Jasjit S Non-Invasive Imaging-Based Prostate Cancer Prediction
US20110257505A1 (en) * 2010-04-20 2011-10-20 Suri Jasjit S Atheromatic?: imaging based symptomatic classification and cardiovascular stroke index estimation
US20110257545A1 (en) * 2010-04-20 2011-10-20 Suri Jasjit S Imaging based symptomatic classification and cardiovascular stroke risk score estimation
US8532360B2 (en) * 2010-04-20 2013-09-10 Atheropoint Llc Imaging based symptomatic classification using a combination of trace transform, fuzzy technique and multitude of features
WO2012082804A2 (en) * 2010-12-13 2012-06-21 Georg-August-Universität Göttingen Medical imaging devices, methods, and systems
CN113013716B (zh) * 2012-06-01 2024-09-20 Nkt光子学有限公司 一种超连续谱光源、测量系统和测量方法
ITMI20121156A1 (it) * 2012-06-29 2013-12-30 Consiglio Nazionale Ricerche Metodo di elaborazione di immagini di tomografia a coerenza ottica
US9200887B2 (en) 2012-10-12 2015-12-01 Thorlabs, Inc. Compact, low dispersion, and low aberration adaptive optics scanning system
WO2014138555A1 (en) * 2013-03-07 2014-09-12 Bernhard Sturm Multimodal segmentation in intravascular images
US9633277B2 (en) 2014-09-12 2017-04-25 Research Development Foundation Apparatus and methods for identifying and evaluating bright spot indications observed through optical coherence tomography
KR102294734B1 (ko) * 2014-09-30 2021-08-30 삼성전자주식회사 영상 정합 장치, 영상 정합 방법 및 영상 정합 장치가 마련된 초음파 진단 장치
US11094058B2 (en) * 2015-08-14 2021-08-17 Elucid Bioimaging Inc. Systems and method for computer-aided phenotyping (CAP) using radiologic images
WO2018005623A1 (en) * 2016-06-28 2018-01-04 The Regents Of The University Of California Fast two-photon imaging by diffracted swept-laser excitation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011521747A (ja) 2008-06-02 2011-07-28 ライトラブ イメージング， インコーポレイテッド 光コヒーレンストモグラフィ画像から組織特徴を取得する定量的方法
JP2013532295A (ja) 2010-07-09 2013-08-15 ソマロジック・インコーポレーテッド 肺癌バイオマーカーとその使用
JP2016515032A (ja) 2013-03-14 2016-05-26 リサーチ ディベロップメント ファウンデーション 光コヒーレンス断層撮影および二光子発光撮像のための装置および方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Lambros S. Athanasiou et al，Methodology for fully automated segmentation and plaque characterization in intracoronary optical coherence tomography images，Journal of Biomedical Optics，2014年02月，Vol.19(2)，026009-1～13

Also Published As

Publication number Publication date
JP7383070B2 (ja) 2023-11-17
EP3468453B1 (en) 2023-12-27
US20230083484A1 (en) 2023-03-16
EP3468453A4 (en) 2020-01-01
EP3468453A1 (en) 2019-04-17
US12213810B2 (en) 2025-02-04
KR102531819B1 (ko) 2023-05-16
KR20190015546A (ko) 2019-02-13
JP2019518581A (ja) 2019-07-04
AU2017277784B2 (en) 2022-06-30
WO2017214421A1 (en) 2017-12-14
CA3026650A1 (en) 2017-12-14
JP2022095854A (ja) 2022-06-28
AU2017277784A1 (en) 2018-12-20

Similar Documents

Publication Publication Date Title
JP7058264B2 (ja) 血管内光干渉断層撮影法を用いた冠動脈プラークの自動特徴分析およびリスク評価のためのシステムおよび方法
AU2019397494B2 (en) Multi-channel orthogonal convolutional neural networks
US9633277B2 (en) Apparatus and methods for identifying and evaluating bright spot indications observed through optical coherence tomography
AU2014236457B2 (en) Apparatus and methods for optical coherence tomography and two-photon luminescence imaging
Leitgeb et al. Multimodal optical medical imaging concepts based on optical coherence tomography
Lee et al. Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging
Paoli et al. Multiphoton laser scanning microscopy—a novel diagnostic method for superficial skin cancers
Turchin Methods of biomedical optical imaging: from subcellular structures to tissues and organs
Qu et al. Miniature probe for mapping mechanical properties of vascular lesions using acoustic radiation force optical coherence elastography
Kiss et al. Quantitative analysis on ex vivo nonlinear microscopy images of basal cell carcinoma samples in comparison to healthy skin
Cheburkanov et al. Porcine vocal fold elasticity evaluation using Brillouin spectroscopy
Villiger et al. Future development
Ko et al. Conference 8207E: Diagnostic and Therapeutic Applications of Light in Cardiology
HK1217227B (zh) 用於光学相干断层扫描和双光子荧光成像的设备和方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200604

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200604

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210430

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210511

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210810

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210907

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211206

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220215

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220315

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220411

R150 Certificate of patent or registration of utility model

Ref document number: 7058264

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees