JP7051686B2 - 大型のキャリアー部分を有するｃｎｐプロドラッグ - Google Patents

大型のキャリアー部分を有するｃｎｐプロドラッグ Download PDF

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JP7051686B2
JP7051686B2 JP2018535304A JP2018535304A JP7051686B2 JP 7051686 B2 JP7051686 B2 JP 7051686B2 JP 2018535304 A JP2018535304 A JP 2018535304A JP 2018535304 A JP2018535304 A JP 2018535304A JP 7051686 B2 JP7051686 B2 JP 7051686B2
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cnp
seq
group
prodrug
alkyl
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JP2019507724A5 (https=
JP2019507724A (ja
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ラウ，ハラルト
ハーセル，ウルリッヒ
クレーマン，フェリックス
エリサベト ラスムセン，カロリーネ
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アセンディス ファーマ グロース ディスオーダーズ エー／エス
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Priority to JP2022054845A priority patent/JP7350123B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018535304A 2016-01-08 2017-01-05 大型のキャリアー部分を有するｃｎｐプロドラッグ Active JP7051686B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021031431A JP6951597B2 (ja) 2016-01-08 2021-03-01 大型のキャリアー部分を有するｃｎｐプロドラッグ
JP2022054845A JP7350123B2 (ja) 2016-01-08 2022-03-30 大型のキャリアー部分を有するｃｎｐプロドラッグ
JP2023147381A JP7692454B2 (ja) 2016-01-08 2023-09-12 大型のキャリアー部分を有するｃｎｐプロドラッグ

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP16150624.1 2016-01-08
EP16150624 2016-01-08
EP16179286 2016-07-13
EP16179286.6 2016-07-13
EP16191458.5 2016-09-29
EP16191458 2016-09-29
PCT/EP2017/050201 WO2017118693A1 (en) 2016-01-08 2017-01-05 Cnp prodrugs with large carrier moieties

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JP2021031431A Division JP6951597B2 (ja) 2016-01-08 2021-03-01 大型のキャリアー部分を有するｃｎｐプロドラッグ
JP2022054845A Division JP7350123B2 (ja) 2016-01-08 2022-03-30 大型のキャリアー部分を有するｃｎｐプロドラッグ

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JP2019507724A JP2019507724A (ja) 2019-03-22
JP2019507724A5 JP2019507724A5 (https=) 2019-12-19
JP7051686B2 true JP7051686B2 (ja) 2022-04-11

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JP2018535304A Active JP7051686B2 (ja) 2016-01-08 2017-01-05 大型のキャリアー部分を有するｃｎｐプロドラッグ
JP2021031431A Active JP6951597B2 (ja) 2016-01-08 2021-03-01 大型のキャリアー部分を有するｃｎｐプロドラッグ
JP2022054845A Active JP7350123B2 (ja) 2016-01-08 2022-03-30 大型のキャリアー部分を有するｃｎｐプロドラッグ
JP2023147381A Active JP7692454B2 (ja) 2016-01-08 2023-09-12 大型のキャリアー部分を有するｃｎｐプロドラッグ

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JP2022054845A Active JP7350123B2 (ja) 2016-01-08 2022-03-30 大型のキャリアー部分を有するｃｎｐプロドラッグ
JP2023147381A Active JP7692454B2 (ja) 2016-01-08 2023-09-12 大型のキャリアー部分を有するｃｎｐプロドラッグ

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US (6) US10835578B2 (https=)
EP (1) EP3400020A1 (https=)
JP (4) JP7051686B2 (https=)
AU (2) AU2017205268B2 (https=)
CA (1) CA3007976C (https=)
MX (1) MX2018008061A (https=)
WO (1) WO2017118693A1 (https=)
ZA (1) ZA201804414B (https=)

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WO2017118700A1 (en) 2016-01-08 2017-07-13 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with increased nep stability
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US11564974B2 (en) 2016-09-29 2023-01-31 Ascendis Pharma Growth Disorders A/S Combination therapy with controlled-release CNP agonists
KR20190125310A (ko) 2017-03-10 2019-11-06 퀴아펙 파마슈티칼스 에이비 방출가능한 접합체
CN111918665B (zh) * 2018-03-28 2024-11-26 阿森迪斯药物肿瘤股份有限公司 Il-2缀合物
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KR20230019889A (ko) 2020-06-03 2023-02-09 아센디스 파마 온콜로지 디비전 에이/에스 Il-2 서열 및 이의 용도
JP2023530273A (ja) * 2020-06-12 2023-07-14 ファーマイン コーポレイション Ｃ型ナトリウム利尿ペプチド及び癌の処置におけるその方法
WO2023110758A1 (en) * 2021-12-13 2023-06-22 Ascendis Pharma Growth Disorders A/S Effective doses of cnp conjugates
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AU2017205268B2 (en) 2022-02-17
US20190015481A1 (en) 2019-01-17
WO2017118693A1 (en) 2017-07-13
JP7692454B2 (ja) 2025-06-13
JP2021100937A (ja) 2021-07-08
US11154593B2 (en) 2021-10-26
EP3400020A1 (en) 2018-11-14
JP6951597B2 (ja) 2021-10-20
MX2018008061A (es) 2018-08-23
JP2022088545A (ja) 2022-06-14
AU2022201416A1 (en) 2022-03-24
JP2023175776A (ja) 2023-12-12
US20240316153A1 (en) 2024-09-26
US20220296682A1 (en) 2022-09-22
AU2017205268A1 (en) 2018-06-07
CA3007976C (en) 2023-09-26
AU2022201416B2 (en) 2023-06-01
US20210177942A1 (en) 2021-06-17
JP7350123B2 (ja) 2023-09-25
US20250127859A1 (en) 2025-04-24
JP2019507724A (ja) 2019-03-22
US10835578B2 (en) 2020-11-17
ZA201804414B (en) 2019-04-24
US20210077584A1 (en) 2021-03-18
CA3007976A1 (en) 2017-07-13

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