JP7032316B2 - 選択的な温度療法のゾーンを提供するためのシステム - Google Patents
選択的な温度療法のゾーンを提供するためのシステム Download PDFInfo
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Description
(1) .... Fb = Gb(Pb - Ptip)
(2) .... (Fb + Ftip) = Gtip(Ptip)
Ftipの値は、(流量供給源616などであるがこれに限定されない)ポンプから設定することができる。図6Aの例示的なシステムを使用して、圧力Pb及び圧力Ptipの値を測定することができる。これらの値を使用すると、式は以下のようにまとめることができる。
(3) .... Gtip = Ftip/Ptip + Gb(Pb-Ptip)/Ptip
ここでGtip及びGbは不明である。血液を身体に戻すために注入部材を使用する手術又は他の医療手順中に、時間T0における最初の注入流れを、F’tipとして使用することができる(非限定的な例として、約250ml/分)。時間T1において、流れのその値がF”tipに変えられてもよい(非限定的な例として約275ml/分、10%の増加)。時間T0及びT1における流れのこれらの非限定的な例示的な値は、注入ポイントの特定の解剖学的構造、及び特定の臨床用途に対して望ましい臨床範囲内になるように選ぶことができる。図6Aの例示的なシステムを使用して、時点T0における圧力Pb及び圧力Ptipの値(P’b及びP’tip)、並びに時点T1における圧力Pb及び圧力Ptipの値(P”b及びP”tip)を測定することができる。圧力の四つの異なる値、及び注入流れの二つの異なる値を、式(3)において使用することによって、すなわち時間T0におけるF’tip、P’tip、P’b、並びに時間T1におけるF”tip、P”tip、及びP”bを導入することによって、二つの(2)式が生成され、それぞれ二つの(2)が不明である。これらの式を使用して、Gb及びGtipの値を算出することができる。式(1)、(2)、及び(3)が、管脈領域の流れ、コンダクタンス、及び圧力に関する式の非限定的な例であることは、当業者には容易に明らかである。より複雑なバージョンの式を含む他の式が適用可能であり得る。例えばコンダクタンスが圧力とは無関係ではなくそれ自体が圧力の関数である式を、適用される流れFtipの異なる値において繰り返した圧力測定値を用いて解き、より多くの式を確立し、線形、又は二次、若しくはより高次の圧力の関数であるコンダクタンス(G)の形式の解を可能にしてもよい。
様々な本発明の実施形態が、本明細書において記述され示されたが、当業者であれば、本明細書において記述された機能を実施するための、並びに/又は、結果及び/若しく利点のうちの一つ以上を得るための様々な他の手段及び/又は構造を容易に想像することができ、そのような変形形態及び/又は修正形態のそれぞれは、本明細書において記述される本発明の実施形態の範囲内にあるとみなされる。より全体的には、本明細書において記述されるすべてのパラメータ、寸法、材料、及び構成は例示的であることが意図されること、及び実際のパラメータ、寸法、材料、及び/又は構成は、本発明の教示が用いられる特定の適用に応じて変わることを、当業者は容易に理解するであろう。当業者は、慣例の範囲内の実験を用いて、本明細書において記述される本発明の特定の実施形態の多くの等価物を認識し、又はそれらを確認することができる。したがって、前述の実施形態は例としてのみ提示されており、添付の請求項及びその等価物の範囲内で、本発明の実施形態は、具体的に記述され特許請求されたものとは異なる態様で実施されてもよいことを、理解すべきである。本開示における本発明の実施形態は、本明細書において記述されるそれぞれの個々の特徴、システム、物品、材料、キット、及び/又は方法を対象とする。さらに、このような二つ以上の特徴、システム、物品、材料、キット、及び/又は方法の任意の組合せは、これらの特徴、システム、物品、材料、キット、及び/又は方法が互いに矛盾しない場合、本開示の発明の範囲に含まれる。
Claims (5)
- 選択的な温度療法の少なくとも二つのゾーンを提供するためのシステムであって、
体外回路であって、
管脈位置に配設された遠位先端を備える注入器部材と、
身体から血液を抜くための非閉塞性の第1のポートと、
前記身体に血液を戻すための非閉塞性の第2のポートと、
前記第1のポートから前記第2のポートへ血液をくみ出すために前記第1のポートと前記第2のポートとの間に配設された第1のポンプと、
前記第1のポンプと第2のポートとの間に位置付けられた分岐セクションと、
前記分岐セクションに結合された、前記注入器部材の体外側に位置付けられた第3のポートと、
前記分岐セクションと前記第3のポートとの間に位置付けられた第2のポンプであって、前記分岐セクションから出て前記第3のポートを通って前記注入器部材に入る流量を制御するように構成された第2のポンプと、
前記第1のポンプと前記第2のポートとの間に配設された、前記第2のポートに注入される血液の温度を第1の温度レベルに設定するように構成された第1の熱交換器と、
前記第2のポンプと前記注入器部材との間に配設された、前記注入器部材に注入される血液の温度を、前記第1の温度レベルとは異なる第2の温度レベルに設定するように構成された第2の熱交換器と
を備える体外回路
を備え、
前記第1のポートから前記分岐セクションまでの間には、前記第1のポンプと前記第1の熱交換器とが、これらの順に配置され、
前記分岐セクションから前記第3のポートまでの間には、前記第2のポンプと第2の熱交換器とが、これらの順に配置されている、システム。 - 前記注入器部材の前記遠位先端に近接して配設された閉塞構成要素をさらに備える、請求項1に記載のシステム。
- 前記第2のポートを使用して灌流される身体の一部分の平均的な中核体温及び/又は平均的なシステム温度を測定するように位置付けられた少なくとも一つの第1の温度センサと、
前記注入器部材によって灌流される局所領域の温度を測定するように位置付けられた少なくとも一つの第2の温度センサと
をさらに備える、請求項1に記載のシステム。 - オペレーティングコンソールであって、
前記第1の熱交換器を駆動するための第1の水冷却器/加熱器と、
前記第2の熱交換器を駆動するための第2の水冷却器/加熱器と、
オペレーティングシーケンスの動作ステップを実施するためのユーザ命令を表示するように構成されたグラフィックユーザインターフェイスと
を備えるオペレーティングコンソール
をさらに備える、請求項3に記載のシステム。 - 前記グラフィックユーザインターフェイスが、
前記少なくとも一つの第1の温度センサによって報告される温度測定値を中核身体目標範囲内にとどめるように調整するために前記第2のポートによって灌流される血液の温度を制御することを、前記体外回路に行わせるため、及び
前記少なくとも一つの第2の温度センサが目標領域温度範囲内の温度測定値を報告するように前記局所領域に注入される血液の温度を制御することを、前記体外回路に行わせるため
のオペレーティングシーケンスを実施するように構成された、請求項4に記載のシステム。
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