JP7019568B2 - 白質脳病変の分析のための医療機器 - Google Patents

白質脳病変の分析のための医療機器 Download PDF

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JP7019568B2
JP7019568B2 JP2018523809A JP2018523809A JP7019568B2 JP 7019568 B2 JP7019568 B2 JP 7019568B2 JP 2018523809 A JP2018523809 A JP 2018523809A JP 2018523809 A JP2018523809 A JP 2018523809A JP 7019568 B2 JP7019568 B2 JP 7019568B2
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image
lesion
fiber
processor
medical device
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JP2018535008A5 (OSRAM
JP2018535008A (ja
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カルステン メイヤー
ファビアン ウェンゼル
マーティン ベルトルト
トーマス ヘイコ ステール
ルボミール ゲオルギエフ ザゴルチェフ
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Koninklijke Philips NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/0037—Performing a preliminary scan, e.g. a prescan for identifying a region of interest
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/0035—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7282—Event detection, e.g. detecting unique waveforms indicative of a medical condition
    • A—HUMAN NECESSITIES
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    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/7475—User input or interface means, e.g. keyboard, pointing device, joystick
    • A61B5/748—Selection of a region of interest, e.g. using a graphics tablet
    • A61B5/7485—Automatic selection of region of interest
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/501—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of the head, e.g. neuroimaging or craniography
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
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    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
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    • G06T7/0012—Biomedical image inspection
    • G06T7/0014—Biomedical image inspection using an image reference approach
    • G06T7/0016—Biomedical image inspection using an image reference approach involving temporal comparison
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
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    • G06T7/10—Segmentation; Edge detection
    • G06T7/11—Region-based segmentation
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    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/33—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B2090/364—Correlation of different images or relation of image positions in respect to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/026—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the brain
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10088—Magnetic resonance imaging [MRI]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20112—Image segmentation details
    • G06T2207/20128—Atlas-based segmentation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20112—Image segmentation details
    • G06T2207/20156—Automatic seed setting
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30016—Brain
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30096—Tumor; Lesion
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Neurosurgery (AREA)
  • Physiology (AREA)
  • Quality & Reliability (AREA)
  • Psychology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Optics & Photonics (AREA)
  • Dentistry (AREA)
  • Artificial Intelligence (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Image Analysis (AREA)
JP2018523809A 2015-11-12 2016-11-11 白質脳病変の分析のための医療機器 Expired - Fee Related JP7019568B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562254236P 2015-11-12 2015-11-12
US62/254236 2015-11-12
PCT/EP2016/077507 WO2017081302A1 (en) 2015-11-12 2016-11-11 Medical instrument for analysis of white matter brain lesions

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JP2018535008A JP2018535008A (ja) 2018-11-29
JP2018535008A5 JP2018535008A5 (OSRAM) 2019-12-19
JP7019568B2 true JP7019568B2 (ja) 2022-02-15

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US (1) US20180344161A1 (OSRAM)
JP (1) JP7019568B2 (OSRAM)
CN (1) CN108289612A (OSRAM)
DE (1) DE112016005184T5 (OSRAM)
WO (1) WO2017081302A1 (OSRAM)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE50823E1 (en) * 2016-10-12 2026-03-17 Mint Labs Inc. Systems and methods for improved tractography images
JP2018175227A (ja) * 2017-04-10 2018-11-15 富士フイルム株式会社 医用画像表示装置、方法およびプログラム
CN109620407B (zh) 2017-10-06 2024-02-06 皇家飞利浦有限公司 治疗轨迹引导系统
US11288803B2 (en) * 2017-10-09 2022-03-29 Koninklijke Philips N.V. Ablation result validation system
US10575753B2 (en) * 2018-05-31 2020-03-03 Boston Medical Center Corporation White matter fibrography by synthetic magnetic resonance imaging
WO2020064664A1 (en) * 2018-09-24 2020-04-02 Koninklijke Philips N.V. Mesial temporal lobe epilepsy classifier based on volume and shape of subcortical brain regions
AU2019351295B2 (en) * 2018-09-28 2024-05-02 The Board Of Regents Of The University Of Texas System Methods, apparatuses, and systems for 3-D phenotyping and physiological characterization of brain lesions and surrounding tissue
CN110244249B (zh) * 2019-03-28 2022-08-23 上海联影医疗科技股份有限公司 磁共振扫描方法、装置、医学扫描设备和存储介质
CN110415228B (zh) * 2019-07-24 2022-11-04 上海联影医疗科技股份有限公司 神经纤维追踪方法、磁共振系统及存储介质
US11145119B2 (en) 2019-10-18 2021-10-12 Omniscient Neurotechnology Pty Limited Differential brain network analysis
FI20195977A1 (en) * 2019-11-15 2021-05-16 Disior Oy SYSTEM AND METHOD FOR CREATING ENHANCED TWO-DIMENSIONAL IMAGE DATA
CN111242169B (zh) * 2019-12-31 2024-03-26 浙江工业大学 一种基于图片相似度计算的脑纤维视角自动选择方法
GB202000634D0 (en) * 2020-01-15 2020-02-26 Nat Institute Of Mental Health Diagnostic method
US11227683B2 (en) * 2020-01-23 2022-01-18 GE Precision Healthcare LLC Methods and systems for characterizing anatomical features in medical images
US11682187B2 (en) * 2020-04-30 2023-06-20 Medtronic Navigation, Inc. Method and apparatus to classify structures in an image
US11508070B2 (en) * 2020-04-30 2022-11-22 Medtronic Navigation, Inc. Method and apparatus to classify structures in an image
JP7338902B2 (ja) * 2020-12-30 2023-09-05 ニューロフェット インコーポレイテッド :診断補助情報の提供方法およびそれの実行する装置
CN116542997B (zh) * 2023-07-04 2023-11-17 首都医科大学附属北京朝阳医院 磁共振图像的处理方法、装置以及计算机设备
CN118351102B (zh) * 2024-05-06 2024-11-19 上海交通大学医学院附属瑞金医院 基于脑白质磁共振信号强度的图像处理方法和系统

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090232374A1 (en) 2008-03-12 2009-09-17 Medtronic Navigation, Inc. Diffusion Tensor Imaging Confidence Analysis
JP2010279591A (ja) 2009-06-05 2010-12-16 Toshiba Corp 医用画像表示装置、医用画像診断装置及びプログラム
WO2011040473A1 (ja) 2009-09-29 2011-04-07 大日本印刷株式会社 医用画像処理方法、装置およびプログラム
JP2011139799A (ja) 2010-01-07 2011-07-21 Toshiba Corp 画像処理装置及び磁気共鳴イメージング装置
US20150023556A1 (en) 2013-07-17 2015-01-22 Samsung Electronics Co., Ltd. Method and apparatus for selecting seed area for tracking nerve fibers in brain

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8170644B2 (en) * 2006-04-18 2012-05-01 The Regents Of The University Of Colorado Method for fast multi-slice mapping of myelin water fraction
WO2008014340A2 (en) * 2006-07-25 2008-01-31 University Of Rochester Prediction and treatment of brain tumor spread using mri and external beam radiation
EP1992957B1 (en) * 2007-05-16 2013-01-02 BrainLAB AG Method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter
US9336590B2 (en) * 2010-09-28 2016-05-10 Brainlab Ag Advanced fiber tracking and medical navigation in a brain
US9921283B2 (en) * 2011-01-28 2018-03-20 The Board Of Trustees Of The Leland Stanford Junior University Methods for detecting abnormalities and degenerative processes in soft tissue using magnetic resonance imaging
CN103049901A (zh) * 2012-08-03 2013-04-17 上海理工大学 磁共振弥散张量成像纤维束追踪装置
CN103489198A (zh) * 2013-10-21 2014-01-01 钟映春 从序列mr图像中自动分割脑干区域的方法
CN103970929A (zh) * 2013-12-23 2014-08-06 浙江工业大学 用于脑白质纤维跟踪的高阶扩散张量混合稀疏成像方法
WO2015164882A1 (en) * 2014-04-25 2015-10-29 The Regents Of The University Of California Quantitating disease progression from the mri images of multiple sclerosis patients
CN103996196B (zh) * 2014-05-28 2017-06-30 西安电子科技大学 一种基于多变量的dti图像分析方法
CN104346530A (zh) * 2014-10-29 2015-02-11 中国科学院深圳先进技术研究院 大脑异常参数的提取方法和系统

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090232374A1 (en) 2008-03-12 2009-09-17 Medtronic Navigation, Inc. Diffusion Tensor Imaging Confidence Analysis
JP2010279591A (ja) 2009-06-05 2010-12-16 Toshiba Corp 医用画像表示装置、医用画像診断装置及びプログラム
WO2011040473A1 (ja) 2009-09-29 2011-04-07 大日本印刷株式会社 医用画像処理方法、装置およびプログラム
JP2011139799A (ja) 2010-01-07 2011-07-21 Toshiba Corp 画像処理装置及び磁気共鳴イメージング装置
US20150023556A1 (en) 2013-07-17 2015-01-22 Samsung Electronics Co., Ltd. Method and apparatus for selecting seed area for tracking nerve fibers in brain

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US20180344161A1 (en) 2018-12-06
CN108289612A (zh) 2018-07-17
WO2017081302A1 (en) 2017-05-18
JP2018535008A (ja) 2018-11-29
DE112016005184T5 (de) 2018-07-26

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