JP7017426B2 - Method for manufacturing a laminate for a biosensor and a laminate for a biosensor - Google Patents

Description

The present invention relates to a laminate for a biosensor and a method for manufacturing a laminate for a biosensor.

Conventionally, a biological sensor that is attached to human skin or the like to detect a biological signal has been known.

For example, a biocompatible polymer substrate comprising a data acquisition module, a viscous polymer layer, an electrode placed on the polymer layer, and wiring connecting the data acquisition module and the electrodes has been proposed (eg,). , Patent Document 1).

Then, in such a biocompatible polymer substrate, a polymer layer is attached to human skin, an electrode detects a biological signal, for example, a voltage signal derived from the myocardium, and a data acquisition module receives a voltage signal derived from the myocardium. And record.

Japanese Unexamined Patent Publication No. 2012-10978

However, in the biocompatible polymer substrate described in Patent Document 1, the wiring is connected to the electrode by point contact. Therefore, in the biocompatible polymer substrate described in Patent Document 1, if the wiring and the electrode are not aligned accurately, the wiring and the electrode may not be connected, and the connection reliability between the wiring and the electrode is improved. Has a limit. As a result, the wiring may not be able to stably and electrically connect the data acquisition module and the electrodes.

Therefore, the present invention provides a biosensor laminate and a method for manufacturing a biosensor laminate that can improve the connection reliability between the connection portion and the probe.

In the present invention [1], the pressure-sensitive adhesive layer for sticking to the surface of a living body, the base material arranged on the upper surface of the pressure-sensitive adhesive layer, the wiring arranged on the base material, and the lower surface are exposed. Provided with a probe arranged in the pressure-sensitive adhesive layer and a connection portion that passes through at least the pressure-sensitive adhesive layer and connects the wiring and the probe, and the connection portion is the entire peripheral edge of the probe. It comprises a biosensor laminate having a shape along at least a portion of the portion and comprising a first contact portion in contact with the peripheral portion of the probe.

According to such a configuration, since the first contact portion of the connection portion has a shape along at least a part of the entire peripheral edge portion of the probe, the first contact portion is at least one of the entire peripheral edge portions of the probe. It can be in continuous contact with the part. Therefore, the first contact portion and the peripheral portion of the probe can be stably brought into contact with each other, and the connection reliability between the connection portion and the probe can be improved. As a result, the connection portion can reliably connect the wiring and the probe.

The present invention [2] includes the laminate for a biosensor according to the above [1], wherein the probe has a thin layer shape.

According to such a configuration, since the probe has a thin layer shape, it is possible to reduce the wearing feeling of the user when the laminate for the biosensor is attached to the surface of the living body.

The present invention [3] includes the laminate for a biosensor according to the above [1] or [2], wherein the first contact portion has an endless shape along the entire peripheral edge portion of the probe.

According to such a configuration, since the first contact portion has an endless shape along the entire peripheral edge portion of the probe, the first contact portion can be continuously contacted with the entire peripheral edge portion of the probe. Therefore, it is possible to further improve the connection reliability between the connection portion and the probe.

In the present invention [4], the first contact portion includes the laminate for a biosensor according to the above [3], which surrounds the probe.

According to such a configuration, since the first contact portion surrounds the probe, the alignment accuracy between the connection portion and the probe can be improved, and the connection reliability between the connection portion and the probe can be further improved. be able to.

In the present invention [5], the connection portion has the same shape or a similar shape as the first contact portion, is arranged so as to face the first contact portion in the vertical direction, and has a second contact portion that comes into contact with the wiring. The biosensor laminate according to any one of the above [1] to [4], comprising a connecting portion for connecting the first contact portion and the second contact portion.

According to such a configuration, the second contact portion of the connection portion has the same shape or a similar shape as the first contact portion, and is arranged so as to face the first contact portion in the vertical direction. It can be brought into contact with the wiring at any part of the part. Therefore, the second contact portion and the wiring can be stably brought into contact with each other, and the connection reliability between the connection portion and the wiring can be improved.

In the present invention [6], the stacking for a biosensor according to the above [5], wherein the connecting portion connects the first contact portion and the second contact portion in the entire circumferential direction of the first contact portion. Including the body.

According to such a configuration, since the connecting portion connects the first contact portion and the second contact portion in the entire circumferential direction of the first contact portion, even if a disconnection occurs in any part of the connecting portion. , The first contact portion and the second contact portion can be reliably connected in other portions of the connecting portion. Therefore, the connection portion can connect the wiring and the probe more reliably.

The present invention [7] prepares a laminate including a pressure-sensitive adhesive layer for sticking to the surface of a living body, a base material arranged on the upper surface of the pressure-sensitive adhesive layer, and wiring arranged on the base material. A step of preparing a probe support which is provided with a thin layered probe and supports the probe so that the peripheral edge of the probe is exposed, and a through hole which penetrates the laminated body in the thickness direction. When the probe support is arranged in the through port, it has a size in which a gap is formed between the inner surface of the through port and the peripheral surface of the probe support so that the wiring and the peripheral edge of the probe face each other. The step of forming the penetration port, the step of arranging the probe support in the penetration port so that the probe is located below the base material and the gap is formed, and the step of arranging the probe support in the gap. It comprises a method of manufacturing a laminate for a biosensor, comprising a step of forming an endless connection portion connecting the wiring and the probe.

According to such a method, after preparing a laminate having a pressure-sensitive adhesive layer, a base material and wiring, and a probe support for supporting the probe so that the peripheral edge of the thin-layered probe is exposed, the laminate A through-hole having the above size is formed in the through-hole, and then a probe support is formed in the through-hole so that a gap is formed between the inner surface of the through-hole and the peripheral surface of the probe support so that the peripheral portion of the wiring and the probe faces. The body is placed, and then an endless connection is formed in the gap to connect the wiring and the probe.

The connection portion thus formed has an endless shape along the entire peripheral edge portion of the probe, and has the same shape or a similar shape as the first contact portion and the first contact portion in contact with the peripheral edge portion of the probe. A second contact portion that comes into contact with the wiring and a connecting portion that connects the first contact portion and the second contact portion are provided.

Therefore, according to the above method, although it is a simple method, it is possible to improve the connection reliability between the connection part and the probe and the wiring, and the connection part can reliably connect the wiring and the probe for the biosensor. The laminate can be smoothly manufactured.

In the present invention [8], the living body according to the above [7], wherein the probe support includes a pressure-sensitive adhesive layer on which the probe is arranged and a base material arranged on the upper surface of the pressure-sensitive adhesive layer. It includes a method for manufacturing a laminate for a sensor.

According to such a method, the probe support is provided with a pressure-sensitive adhesive layer and a base material, and the layer structure of the probe support can be the same as the layer structure of the laminated body, so that the probe support is flexible. The properties can be similar to the flexibility of the laminate. Therefore, it is possible to suppress the occurrence of different flexibility portions in the biosensor laminate.

As a result, it is possible to manufacture a laminate for a biosensor that can reduce the wearing feeling of the user.

The laminated body for a biosensor of the present invention can improve the connection reliability between the connection portion and the probe.

The method for manufacturing a laminate for a biosensor of the present invention can improve the connection reliability between the connection portion and the probe and the wiring, and the connection portion can reliably connect the wiring and the probe for the biosensor. A laminate can be manufactured.

FIG. 1 shows a plan view of an embodiment of the laminate for a biological sensor of the present invention. FIG. 2 is a cross-sectional view taken along the line AA of the laminate for a biosensor shown in FIG. FIG. 3A is a perspective view of the probe member shown in FIG. FIG. 3B is a perspective view of the connection portion shown in FIG. FIG. 3C is a perspective view of the through hole shown in FIG. 4A to 4D are manufacturing process diagrams of the laminate for a biological sensor shown in FIG. 1, FIG. 4A is a process of preparing a base material and a wiring layer, and FIG. 4B is a pressure-sensitive adhesive layer and a base material attached. The matching step, FIG. 4C shows a step of forming a through hole and fitting a probe member, and FIG. 4D shows a step of forming a connecting portion. FIG. 5 is a perspective view of the probe-containing sheet as viewed from below, showing a state in which the second release sheet is partially cut off. FIG. 6 is a perspective view illustrating a manufacturing process of the probe member. FIG. 7A is a cross-sectional view of a laminate for a biosensor (a mode in which the probe is larger than the first contact portion) of a modified example of the embodiment. FIG. 7B is a perspective view of the connection portion and the probe shown in FIG. 7A. 8A to 8D are perspective views of a modified example of the connecting portion, FIG. 8A shows an embodiment in which the connecting portion is a plurality of connecting columns, and FIG. 8B shows the connecting portion having no second contact portion and having a second contact portion. 1 An embodiment consisting of a contact portion and a connecting pillar, FIG. 8C shows an embodiment in which the connecting portion has a tapered shape, and FIG. 8D shows an embodiment in which the connecting portion has a half-split ring shape in a plan view. FIG. 9 shows a cross-sectional view of a laminate for a biosensor (a mode in which a probe is supported by a support layer) of a modified example of one embodiment. 10A and 10B are explanatory views for explaining a modified example of one embodiment of the manufacturing process of the laminate for a biological sensor, and FIG. 10A shows an embodiment in which a cylindrical connection portion is fitted into a gap. FIG. 10B shows an embodiment in which an integrated probe including a probe and a connection portion is fitted in a gap. 11A to 11C are explanatory views for explaining a modified example of one embodiment of the manufacturing process of the laminate for a biological sensor, FIG. 11A is an embodiment in which a probe sheet is prepared, and FIG. 11B is a probe sheet. An aspect of arranging the joint member and the pressure-sensitive adhesive sheet in FIG. 11C shows an aspect of arranging the joining member and the pressure-sensitive adhesive sheet. 12A and 12B are explanatory views for explaining a modification of one embodiment of the manufacturing process of the laminate for a biological sensor, and FIG. 12A shows an embodiment in which a wiring layer, a connection portion, and a probe are collectively formed. , FIG. 12B shows an aspect in which the probe is attached after the connection portion is formed. 13A and 13B are explanatory views for explaining a modified example of one embodiment of the manufacturing process of the laminate for a biological sensor, FIG. 13A is an embodiment in which the probe has a cylindrical shape, and FIG. 13B is a probe member. The thickness of is smaller than the thickness of the laminated body.

<One Embodiment>
1. 1. Schematic Configuration of Laminates for Biosensors Laminates 1 for biosensors as an embodiment of the laminates for biosensors of the present invention will be described with reference to FIGS. 1 to 6.

In FIG. 1, the left-right direction of the paper surface is the longitudinal direction (first direction) of the biosensor laminate 1. The right side of the paper surface is one side in the longitudinal direction (one side in the first direction), and the left side of the paper surface is the other side in the longitudinal direction (the other side in the first direction).

In FIG. 1, the vertical direction of the paper surface is the lateral direction (direction orthogonal to the longitudinal direction, width direction, and second direction orthogonal to the first direction) of the laminate 1 for biosensors. The upper side of the paper surface is one side in the lateral direction (one side in the width direction, one side in the second direction), and the lower side of the paper surface is the other side in the lateral direction (the other side in the width direction, the other side in the second direction).

In FIG. 1, the paper thickness direction is the vertical direction (thickness direction, third direction orthogonal to the first direction and the second direction) of the biosensor laminate 1. The front side of the paper surface is the upper side (one side in the thickness direction, one side in the third direction), and the back side of the paper surface is the lower side (the other side in the thickness direction, the other side in the third direction).

The direction conforms to the direction arrow shown in each drawing.

By defining these directions, there is no intention of limiting the orientations of the biosensor laminate 1 and the patch-type electrocardiograph 30 (described later) during manufacturing and use.

As shown in FIGS. 1 and 2, the biosensor laminate 1 has a substantially flat plate shape extending in the longitudinal direction. The biosensor laminate 1 includes a pressure-sensitive adhesive layer 2 for sticking to the surface of a living body, a base material 3 arranged on the upper surface of the pressure-sensitive adhesive layer 2, and a wiring layer 4 arranged on the base material 3. A probe 5 arranged on the pressure-sensitive adhesive layer 2 and a connecting portion 6 for connecting the wiring layer 4 and the probe 5 are provided. In FIG. 1, for convenience, the pressure-sensitive adhesive layer 2 and the base material 3 that overlap the probe 5 in the vertical direction are omitted.

The pressure-sensitive adhesive layer 2 forms the lower surface of the biosensor laminate 1. The pressure-sensitive adhesive layer 2 is a layer that imparts pressure-sensitive adhesiveness to the lower surface of the biosensor laminate 1 in order to attach the lower surface of the biosensor laminate 1 to the biological surface (skin 33 or the like). .. The pressure-sensitive adhesive layer 2 forms the outer shape of the laminate 1 for a biosensor. The pressure-sensitive adhesive layer 2 has, for example, a flat plate shape extending in the longitudinal direction. Specifically, the pressure-sensitive adhesive layer 2 may have a strip shape extending in the longitudinal direction and a shape in which the central portion in the longitudinal direction bulges toward both outer sides in the lateral direction. Further, in the pressure-sensitive adhesive layer 2, the both end edges in the lateral direction of the central portion in the longitudinal direction are located on both outer sides in the lateral direction with respect to both end edges in the lateral direction other than the central portion in the longitudinal direction.

The pressure-sensitive adhesive layer 2 has an adhesive upper surface 8 and an adhesive lower surface 9. The adhesive upper surface 8 is a flat surface. The adhesive lower surface 9 is arranged to face the lower side of the adhesive upper surface 8 at intervals.

Further, the pressure-sensitive adhesive layer 2 has adhesive openings 11 at both ends in the longitudinal direction thereof. Each of the two adhesive openings 11 has a substantially ring shape in plan view. The adhesive opening 11 penetrates the pressure-sensitive adhesive layer 2 in the thickness direction. The adhesive opening 11 is filled with the connecting portion 6.

Further, the adhesive lower surface 9 inside the adhesive opening 11 has an adhesive groove 10 corresponding to the probe 5 (described later). The adhesive groove 10 is opened downward.

The material of the pressure-sensitive adhesive layer 2 is not particularly limited as long as it is a material having pressure-sensitive adhesiveness, and a material having biocompatibility is preferable. Examples of such a material include an acrylic pressure-sensitive adhesive, a silicone-based pressure-sensitive adhesive, and the like, preferably an acrylic pressure-sensitive adhesive. Examples of the acrylic pressure-sensitive adhesive include those containing an acrylic polymer as a main component described in JP-A-2003-342541.

The thickness of the pressure-sensitive adhesive layer 2 is, for example, 10 μm or more, preferably 20 μm or more, for example, less than 100 μm, preferably 50 μm or less, as the distance between the adhesive upper surface 8 and the adhesive lower surface 9 in the region other than the adhesive groove 10. be.

The dimensions of the pressure-sensitive adhesive layer 2 in a plan view are appropriately set according to the skin 33 (described later) to which the adhesive electrocardiograph 30 (described later) is attached. The lengthwise dimension of the pressure-sensitive adhesive layer 2 is, for example, 30 mm or more, preferably 50 mm or more, for example, 1000 mm or less, preferably 200 mm or less. The dimension of the pressure-sensitive adhesive layer 2 in the lateral direction is, for example, 5 mm or more, preferably 10 mm or more, for example, 300 mm or less, preferably 100 mm or less.

The area of the pressure-sensitive adhesive layer 2 is, for example, 150 mm ² or more, preferably 500 mm ² or more, for example, 300,000 mm ² or less, preferably 20000 mm ² or less.

The base material 3 forms the upper surface of the biosensor laminate 1. The base material 3 and the pressure-sensitive adhesive layer 2 form the outer shape of the laminate 1 for a biosensor. The plan view shape of the base material 3 is the same as the plan view shape of the pressure-sensitive adhesive layer 2. The base material 3 is arranged on the entire upper surface of the pressure-sensitive adhesive layer 2 (however, excluding the region where the connecting portion 6 is provided). The base material 3 is a support layer that supports the pressure-sensitive adhesive layer 2. The base material 3 has a flat plate shape extending in the longitudinal direction.

The base material 3 has a base material lower surface 12 and a base material upper surface 13. The lower surface 12 of the base material is a flat surface. The lower surface 12 of the base material is in contact with the upper surface 8 of the pressure-sensitive adhesive layer 2 (pressure-sensitive adhesion).

The base material upper surface 13 is arranged to face the upper side of the base material lower surface 12 at intervals. The base material upper surface 13 has a base material groove 14 corresponding to the wiring layer 4. The base material groove 14 has the same pattern shape as the wiring layer 4 in a plan view. The base material groove 14 is opened upward.

Further, the base material 3 has a base material opening 15 corresponding to the adhesive opening 11. The base material opening 15 communicates with the adhesive opening 11 in the thickness direction. The base material opening 15 has a substantially ring shape in a plan view having the same shape and dimensions as the adhesive opening 11.

The material of the base material 3 has elasticity, for example. Further, the material of the base material 3 has, for example, an insulating layer. Examples of such a material include resin. Examples of the resin include thermoplastic resins such as polyurethane resins, silicone resins, acrylic resins, polystyrene resins, vinyl chloride resins, and polyester resins.

As the material of the base material 3, a polyurethane resin is preferable from the viewpoint of ensuring more excellent elasticity and moisture permeability.

The thickness of the base material 3 is, for example, 1 μm or more, preferably 5 μm or more, for example, 300 μm or less, preferably 10 μm or less, as a distance between the base material lower surface 12 and the base material upper surface 13 in a region other than the base material groove 14. Is.

The wiring layer 4 is embedded in the base material groove 14. Specifically, the wiring layer 4 is embedded in the upper part of the base material 3 so as to be exposed from the upper surface 13 of the base material of the base material 3. The wiring layer 4 has an upper surface and a lower surface arranged so as to be spaced apart from each other, and a side surface connecting the peripheral edges thereof. All of the bottom surface and all of the side surfaces are in contact with the base material 3. The upper surface is exposed from the base material upper surface 13 (excluding the base material groove 14). The upper surface of the wiring layer 4 forms the upper surface of the biosensor laminate 1 together with the upper surface 13 of the base material.

The wiring layer 4 has a wiring pattern for connecting the connection portion 6 to the electronic component 31 (described later) and the battery 32 (described later). Specifically, the wiring layer 4 independently includes the first wiring pattern 41 and the second wiring pattern 42.

The first wiring pattern 41 is arranged on one side in the longitudinal direction of the base material 3. The first wiring pattern 41 includes a first wiring 16A, and a first terminal 17A and a second terminal 17B continuous with the first wiring 16A.

The first wiring pattern 41 has a substantially T-shape in a plan view. Specifically, the first wiring 16A of the first wiring pattern 41 is arranged on the base material 3, extends from one end in the longitudinal direction (connecting portion 6 located at) of the base material 3 toward the other side in the longitudinal direction, and is a base. It branches at the central portion of the material 3 in the longitudinal direction and extends toward both outer sides in the lateral direction. The first wiring 16A may have a wavy shape in order to improve the elasticity of the biosensor laminate 1.

Each of the first terminal 17A and the second terminal 17B is arranged at both ends in the lateral direction in the central portion in the longitudinal direction of the base material 3. Each of the first terminal 17A and the second terminal 17B has a substantially rectangular shape (land shape) in a plan view. Each of the first terminal 17A and the second terminal 17B is continuous with both ends of the first wiring 16A extending outward on both sides in the lateral direction in the central portion in the longitudinal direction of the base material 3.

The second wiring pattern 42 is provided on the other side in the longitudinal direction of the first wiring pattern 41 at intervals. The second wiring pattern 42 includes a second wiring 16B, and a third terminal 17C and a fourth terminal 17D that are continuous with the second wiring 16B.

The second wiring pattern 42 has a substantially T-shape in a plan view. Specifically, the second wiring 16B of the second wiring pattern 42 is arranged on the base material 3 and extends from the other end in the longitudinal direction (the connecting portion 6 located at) of the base material 3 toward one side in the longitudinal direction. It branches at the central portion of the base material 3 in the longitudinal direction and extends toward both outer sides in the lateral direction. The second wiring 16B may have a wavy shape in order to improve the elasticity of the biosensor laminate 1.

Each of the third terminal 17C and the fourth terminal 17D is arranged at both ends in the lateral direction in the central portion in the longitudinal direction of the base material 3. Each of the third terminal 17C and the fourth terminal 17D has a substantially rectangular shape (land shape) in a plan view. Each of the third terminal 17C and the fourth terminal 17D is continuous with both ends of the second wiring 16B extending outward on both sides in the lateral direction in the central portion in the longitudinal direction of the base material 3.

Examples of the material of the wiring layer 4 include conductors such as copper, nickel, gold, and alloys thereof, and copper is preferable.

The thickness of the wiring layer 4 is, for example, 0.1 μm or more, preferably 1 μm or more, for example, 100 μm or less, preferably 10 μm or less.

The probe 5 is an electrode that, when the pressure-sensitive adhesive layer 2 is attached to the surface of a living body, comes into contact with the surface of the living body and senses an electric signal from the living body, temperature, vibration, sweat, metabolites, and the like. In the present embodiment, the probe 5 has a thin layer shape and is embedded in the adhesive groove 10 of the pressure-sensitive adhesive layer 2 so that the lower surface 20 of the probe is exposed inside the adhesive opening 11. That is, the probe 5 is embedded in the lower end portion of the pressure-sensitive adhesive layer 2 inside the adhesive opening 11. The probe 5 has a grid shape, and includes a crosspiece 53 in which linear crosspieces are arranged in a mesh shape, and a plurality of holes 52 partitioned by the crosspiece 53. The plurality of holes 52 are arranged at intervals from each other, and each hole 52 is filled with the pressure-sensitive adhesive layer 2.

The probe 5 has a probe lower surface 20, a probe upper surface 21 which is spaced apart from the upper surface of the probe lower surface 20, and a side surface which connects the probe lower surface 20 and the peripheral edge of the probe upper surface 21.

The probe lower surface 20 is the lower surface of the crosspiece 53 and is exposed from the adhesive lower surface 9 of the pressure-sensitive adhesive layer 2. The probe lower surface 20 is flush with the adhesive lower surface 9. The probe lower surface 20 forms the lower surface of the biosensor laminate 1 together with the adhesive lower surface 9. The probe upper surface 21 is the upper surface of the crosspiece 53. The upper surface 21 and the side surface of the probe are embedded and covered with the pressure-sensitive adhesive layer 2.

As shown in FIG. 3A, the outermost surface of the side surface of the probe 5 is the outer surface 22 as an example of the peripheral edge of the probe 5. The outer side surface 22 is a peripheral end surface of the crosspiece 53, and forms a virtual circle that passes through the outer surface 22 in a plan view. A plurality of outer side surfaces 22 are arranged at intervals in the circumferential direction of the probe 5.

Examples of the material of the probe 5 include the material (specifically, the conductor) exemplified in the wiring layer 4.

The external dimensions of the probe 5 are set so that the virtual circle passing through the outer surface 22 overlaps the inner peripheral surface partitioning the adhesive opening 11 in a plan view.

The thickness of the probe 5 is, for example, 0.1 μm or more, preferably 1 μm or more, for example, less than 100 μm, preferably 10 μm or less.

As shown in FIG. 2, the connecting portion 6 passes at least in the pressure-sensitive adhesive layer 2 and connects the wiring layer 4 and the probe 5. In the present embodiment, the connecting portion 6 penetrates (passes) the base material 3 and the pressure-sensitive adhesive layer 2 in the thickness direction (vertical direction), and electrically connects the wiring layer 4 and the probe 5. The connecting portion 6, which will be described in detail later, is provided corresponding to the base material opening 15 and the adhesive opening 11, and has the same shape as the connecting portion 6. The connecting portion 6 is filled in the base material opening 15 and the adhesive opening 11.

The connection portion 6 is pressure-sensitively adhered to the pressure-sensitive adhesive layer 2 on the outside of the adhesive opening 11 and the pressure-sensitive adhesive layer 2 on the inside of the adhesive opening 11. Further, the connecting portion 6 is in contact with the base material 3 outside the base material opening 15 and the base material 3 inside the base material opening 15. Further, the inner surface of the connecting portion 6 is in contact with the outer surface 22 of the probe 5.

As shown in FIG. 1, two connecting portions 6 are provided at intervals in the longitudinal direction. Of the two connecting portions 6, the connecting portion 6 located on one side in the longitudinal direction is continuous with one end edge in the longitudinal direction of the first wiring 16A located on one side in the longitudinal direction at the upper end portion thereof. The connection portion 6 located on the other side in the longitudinal direction is continuous with the other end edge in the longitudinal direction of the second wiring 16B located on the other side in the longitudinal direction at the upper end portion thereof. As a result, the connecting portion 6 electrically connects the wiring layer 4 and the probe 5.

Examples of the material of the connecting portion 6 include metals, conductive resins (including conductive polymers), and preferably conductive resins.

The thickness (length in the vertical direction) of the connecting portion 6 is the same as the total thickness of the base material 3 and the pressure-sensitive adhesive layer 2. The radial length of the connecting portion 6 (half the value obtained by subtracting the inner diameter from the outer diameter) is, for example, 1 μm or more, preferably 100 μm or more, for example, 1000 μm or less, preferably 500 μm or less.

2. 2. Details of the Connection Unit Next, the details of the connection unit 6 will be described with reference to FIGS. 2, 3A and 3B.

As shown in FIG. 3B, the connecting portion 6 has a substantially cylindrical shape in which the axis extends in the vertical direction (thickness direction) in the present embodiment. The connecting portion 6 is a connecting portion that connects the first contact portion 61 that contacts the outer surface 22 of the probe 5, the second contact portion 62 that contacts the wiring layer 4, and the first contact portion 61 and the second contact portion. It is equipped with 63. The connecting portion 6 integrally includes the first contact portion 61, the second contact portion 62, and the connecting portion 63. However, in FIG. 3B, for convenience, the connecting portion 6 is connected to the first contact portion 61 and the first contact portion 61 by a dotted line. It is divided into two contact portions 62 and a connecting portion 63.

As shown in FIGS. 3A and 3B, the first contact portion 61 is a portion in contact with the probe 5 at the lower end portion of the connection portion 6. The first contact portion 61 has a shape along at least a part of the plurality of outer surfaces 22 (an example of the entire peripheral edge portion) of the probe 5. In this embodiment, the first contact portion 61 has an endless shape along all of the plurality of outer surfaces 22 of the probe 5. Specifically, the first contact portion 61 has a plan view annular shape along a virtual circle passing through the outer surface 22. The inner diameter of the first contact portion 61 is substantially the same as the diameter of the virtual circle passing through the outer surface 22, and the outer diameter of the first contact portion 61 is substantially the same as the inner diameter of the adhesive opening 11.

As shown in FIG. 2, the first contact portion 61 is arranged at the lower end portion in the adhesive opening 11. The lower surface of the first contact portion 61 is flush with the adhesive lower surface 9. The first contact portion 61 surrounds the probe 5. The first contact portion 61 overlaps with the probe 5 when projected in the radial direction of the connection portion 6. The inner surface (inner peripheral surface) of the first contact portion 61 is in contact with the outer surface 22 of the probe 5. That is, the probe 5 is arranged in the first contact portion 61 so that the outer surface 22 comes into contact with the inner surface of the first contact portion 61. As a result, the connection portion 6 and the probe 5 are electrically connected. Further, the outer surface (outer peripheral surface) of the first contact portion 61 is pressure-sensitively adhered to the pressure-sensitive adhesive layer 2 on the outer side of the adhesive opening 11.

The thickness direction dimension of the first contact portion 61 is, for example, the same as the thickness of the probe 5, and is, for example, 3% or more and 50% or less with respect to the entire thickness direction dimension of the connection portion 6.

As shown in FIGS. 3A and 3B, the second contact portion 62 is a portion of the upper end portion of the connection portion 6 in which a portion in contact with the wiring layer 4 is projected in the radial direction. The second contact portion 62 is arranged so as to face the first contact portion 61 in the vertical direction. The second contact portion 62 has the same shape as the first contact portion 61. Specifically, the second contact portion 62 has the same plan-viewing annular shape as the first contact portion 61. The inner diameter of the second contact portion 62 is substantially the same as the inner diameter of the first contact portion 61, the outer diameter of the second contact portion 62 is substantially the same as the outer diameter of the first contact portion 61, and the base material. It is substantially the same as the inner diameter of the opening 15.

As shown in FIG. 2, the second contact portion 62 is arranged in the base material opening 15. The upper surface of the second contact portion 62 is flush with the upper surface surface 13 of the base material. The second contact portion 62 overlaps with the wiring layer 4 (first wiring 16A or second wiring 16B) when projected in the radial direction of the connection portion 6. The outer surface (outer peripheral surface) of the second contact portion 62 is in contact with the end surface of the first wiring 16A or the end surface of the second wiring 16B. As a result, the connection portion 6 and the wiring layer 4 are electrically connected. Further, of the outer surface (outer peripheral surface) of the second contact portion 62, the portion that contacts the end surface of the first wiring 16A or the end surface of the second wiring 16B is in contact with the base material 3 outside the base material opening 15. is doing. The inner surface (inner peripheral surface) of the second contact portion 62 is in contact with the base material 3 inside the base material opening 15.

The dimension in the thickness direction of the second contact portion 62 is, for example, the same as the thickness of the wiring layer 4, and is, for example, 1% or more and 50% or less with respect to the entire dimension in the thickness direction of the connection portion 6.

As shown in FIG. 3B, the connecting portion 63 is a portion of the connecting portion 6 between the first contact portion 61 and the second contact portion 62. The connecting portion 63 electrically connects the first contact portion 61 and the second contact portion 62 at a plurality of positions spaced apart from each other in the circumferential direction of the first contact portion 61. Specifically, the connecting portion 63 connects the first contact portion 61 and the second contact portion 62 in the entire circumferential direction of the first contact portion 61, and connects the first contact portion 61 and the second contact portion 62. Connect electrically continuously in the circumferential direction.

The connecting portion 63 has a substantially cylindrical shape in which the axis extends in the vertical direction. The inner diameter of the connecting portion 63 is substantially the same as the inner diameter of the first contact portion 61, and the outer diameter of the connecting portion 63 is substantially the same as the outer diameter of the first contact portion 61. The outer surface (outer peripheral surface) of the connecting portion 63 is in contact with the pressure-sensitive adhesive layer 2 and the base material 3 on the outer side of the adhesive opening 11, and the inner surface (inner peripheral surface) of the connecting portion 63 is the adhesive opening. It is in contact with the pressure-sensitive adhesive layer 2 and the base material 3 inside the 11.
3. 3. Method for Manufacturing Laminate for Biosensor Next, a method for manufacturing the laminate 1 for biosensor will be described with reference to FIGS. 4A to 6.

As shown in FIGS. 4A to 4C, in this method, for example, first, the laminated body 28 and the probe member 18 as an example of the probe support are separately prepared.

The laminate 28 includes a pressure-sensitive adhesive layer 2 for sticking to the surface of a living body, a base material 3 arranged on the upper surface of the pressure-sensitive adhesive layer 2, and a wiring layer 4 arranged on the base material 3.

Each of the pressure-sensitive adhesive layer 2, the base material 3 and the wiring layer 4 in the laminated body 28 has the same configuration as each of the pressure-sensitive adhesive layer 2, the base material 3 and the wiring layer 4 described above.

To prepare the laminate 28, for example, after preparing the base material 3 on which the wiring layer 4 is arranged, the pressure-sensitive adhesive layer 2 is arranged on the lower surface surface 12 of the base material of the base material 3.

The base material 3 on which the wiring layer 4 is arranged is prepared by embedding the wiring layer 4 in the base material groove 14 by, for example, the methods described in JP-A-2017-22236 and JP-A-2017-22237. To.

Next, in order to arrange the pressure-sensitive adhesive layer 2 on the lower surface 12 of the base material, for example, first, a coating liquid containing the material of the pressure-sensitive adhesive layer 2 is prepared, and then the coating liquid is applied to the first release sheet 19. It is applied to the upper surface and then dried by heating. As a result, the pressure-sensitive adhesive layer 2 is arranged on the upper surface of the first release sheet 19. The first release sheet 19 has, for example, a substantially flat plate shape extending in the longitudinal direction. Examples of the material of the first release sheet 19 include a resin such as polyethylene terephthalate.

After that, the pressure-sensitive adhesive layer 2 and the base material 3 are bonded together by, for example, a laminator or the like. Specifically, the adhesive upper surface 8 of the pressure-sensitive adhesive layer 2 and the substrate lower surface 12 of the base material 3 are brought into contact with each other.

At this point, each of the base material 3 and the pressure-sensitive adhesive layer 2 does not have the base material opening 15 and the adhesive opening 11.

As a result, the laminated body 28 supported by the first release sheet 19 is prepared.

Further, as shown in FIGS. 4C and 6, the probe member 18 is prepared.

The probe member 18 includes at least a thin layered probe 5, and in the present embodiment, further includes a pressure-sensitive adhesive layer 2 on which the probe 5 is arranged and a base material 3 arranged on the upper surface of the pressure-sensitive adhesive layer 2. ..

Each of the pressure-sensitive adhesive layer 2, the base material 3 and the probe 5 in the probe member 18 has the same configuration as each of the pressure-sensitive adhesive layer 2, the base material 3 and the probe 5 described above.

To prepare the probe member 18, first, as shown in FIG. 5, the probe-containing sheet 26 is prepared.

The probe-containing sheet 26 includes a pressure-sensitive adhesive layer 2, a probe pattern 25 embedded in the pressure-sensitive adhesive layer 2, and a base material 3 arranged on the adhesive upper surface 8 of the pressure-sensitive adhesive layer 2.

The probe pattern 25 has the same pattern shape as the probe 5, and the material of the probe pattern 25 is the same as the material of the probe 5. The probe pattern 25 has a flat area larger than the virtual circle passing through the outer surface 22 of the probe 5.

The probe-containing sheet 26 is prepared, for example, by the methods described in JP-A-2017-22236 and JP-A-2017-22237. Specifically, after forming the probe pattern 25 on the upper surface of the seed layer formed on the release layer, a coating liquid containing the material of the pressure-sensitive adhesive layer 2 is applied and cured to form the pressure-sensitive adhesive layer 2. After forming, the base material 3 is bonded to each other with, for example, a laminator, and then the release layer and the seed layer are removed, and if necessary, the second release sheet 29 is attached to the lower surface of the pressure-sensitive adhesive layer 2. match. The second release sheet 29 has the same configuration as the first release sheet 19 described above.

As a result, the probe-containing sheet 26 is prepared.

Next, as shown in FIG. 6, the cutting line 27 is formed on the probe pattern 25, the pressure-sensitive adhesive layer 2 and the base material 3 in a substantially circular shape in a plan view. The cutting line 27 is formed by, for example, punching. The cutting line 27 divides the probe pattern 25, the pressure-sensitive adhesive layer 2 and the base material 3 into and out of the probe pattern 25, but is not formed on the second release sheet 29. The dimensions of the cutting line 27 are the same as the inner diameters of the adhesive opening 11 and the base material opening 15. That is, the cutting line 27 coincides with the virtual circle passing through the outer surface 22.

By forming the cutting line 27, the probe member 18 is formed.

In the probe member 18, the outer surface 22 of the probe 5 is flush with the outer surface of the pressure-sensitive adhesive layer 2. Further, in the probe member 18, the outer surface 22 is exposed radially outward from the outer surface of the pressure-sensitive adhesive layer 2. That is, the probe member 18 supports the probe 5 so that the outer surface 22 of the probe 5 is exposed.

Subsequently, as shown by the arrow in FIG. 6, the probe member 18 is pulled up from the second release sheet 29. Specifically, the adhesive lower surface 9 and the probe lower surface 20 of the probe member 18 are peeled off from the second release sheet 29.

As described above, the probe member 18 is prepared.

The thickness (vertical dimension) of the probe member 18 is preferably the same as the thickness of the laminated body 28.

Next, as shown in FIG. 4C, a through hole 23 is formed in the laminated body 28.

The through port 23 penetrates the laminated body 28 in the vertical direction (thickness direction). The through hole 23 is a hole (through hole) having a substantially circular shape in a plan view, which is partitioned by an outer peripheral surface for partitioning the base material opening 15 and an outer peripheral surface for partitioning the adhesive opening 11. Further, the end surface of the first wiring 16A (or the end surface of the second wiring 16B) of the wiring layer 4 faces the through port 23. The through hole 23 is opened upward. On the other hand, the lower end of the through hole 23 is closed by the first release sheet 19.

As shown in FIGS. 3C and 4C, the inner diameter of the through port 23 is larger than the outer diameter of the probe member 18. The through hole 23 has a size in which a gap 100 (see FIG. 4D) is formed between the inner surface 23A of the through port 23 and the peripheral surface 18A of the probe member 18 when the probe member 18 is arranged in the through port 23. Has.

To form the through hole 23, the laminate 28 is punched or half-etched, for example.

Next, as shown by the arrow in FIG. 4C, the probe member 18 is placed in the through hole 23 so that the probe 5 is located below the base material 3 and the gap 100 is formed. Deploy.

In the gap 100, the pressure-sensitive adhesive layer 2, the base material 3 and the probe 5 of the probe member 18 and the pressure-sensitive adhesive layer 2 and the base material 3 around the through hole 23 are spaced apart from each other in the radial direction of the probe member 18. It is formed by vacant position. The gap 100 surrounds the probe member 18 and has a substantially annular shape in a plan view. The wiring layer 4 (the end surface of the first wiring 16A or the end surface of the second wiring 16B) and the outer surface 22 of the probe 5 face the gap 100.

After that, as shown in FIG. 4D, a connection portion 6 for electrically connecting the wiring layer 4 and the probe 5 is formed in the gap 100.

When the material of the connecting portion 6 is a conductive resin composition, the conductive resin composition is injected (or coated) into the gap 100. Then, if necessary, the conductive resin composition is heated and cured. As a result, an endless connection portion 6, specifically, a connection portion 6 having a substantially cylindrical shape extending in the vertical direction and having the above-mentioned first contact portion 61, second contact portion 62, and connection portion 63 is formed. ..

As a result, the laminated body 1 for a biological sensor is manufactured.

The biosensor laminate 1 includes a pressure-sensitive adhesive layer 2, a base material 3, a wiring layer 4, a probe 5, a connection portion 6, and a first release sheet 19, preferably from only them. Become. As shown in FIG. 2, the biosensor laminate 1 does not include the first release sheet 19, but only has a pressure-sensitive adhesive layer 2, a base material 3, a wiring layer 4, a probe 5, and a connection portion 6. It may consist of.

The biosensor laminate 1 is a device that is distributed independently and can be used industrially. Specifically, the biosensor laminate 1 can be distributed independently of the electronic component 31 and the battery 32 (see the virtual line in FIG. 1) described below. That is, the laminate 1 for the biosensor does not have the electronic component 31 and the battery 32 mounted therein, and is a component for manufacturing the stick-on electrocardiograph 30.

Next, a method of manufacturing the sticking type electrocardiograph 30 and a method of using the sticking type electrocardiograph 30 as an example of the biosensor will be described using the laminated body 1 for the biosensor.

As shown in FIGS. 1 and 2, in order to manufacture the patch-type electrocardiograph 30, for example, first, for example, a laminate 1 for a biosensor, an electronic component 31, and a battery 32 are prepared.

As the electronic component 31, for example, an analog front end for processing and storing an electric signal from a living body acquired by the probe 5, a microcomputer, a memory, and further, the electric signal is converted into a radio wave and received externally. Examples include a communication IC for wirelessly transmitting to a machine, a transmitter, and the like. The electronic component 31 may have a part or all of them. More specifically, the potential change of the heart acquired by the probe 5 is converted into digital data by the analog front end, and the potential change of the heart is recorded in the memory. As an example, the potential change of the heart is recorded in a memory at a data rate of 16 bits and 1 kHz. In order to reduce the size of the memory, the resolution and data rate of the data may be lowered. The recorded data is analyzed by taking out the data from the memory after removing the biosensor after the measurement. Further, the communication IC in the electronic component 31 has a function of wirelessly transmitting the signal acquired by the probe 5 to the outside. This function intermittently indicates that the data acquisition is normal when the biosensor is attached to the living body, and that the data acquisition is performed normally. It may be sent to to confirm that the biosensor is operating normally.

The electronic component 31 has two terminals (not shown) or two or more terminals (not shown) provided on the lower surface thereof.

The battery 32 has two terminals (not shown) provided on its lower surface.

Next, the two terminals of the electronic component 31 are electrically connected to the first terminal 17A and the third terminal 17C. Further, the two terminals of the battery 32 are electrically connected to the second terminal 17B and the fourth terminal 17D.

As a result, a stick-on electrocardiograph 30 including the laminate 1 for a biosensor and the electronic component 31 and the battery 32 mounted on the laminate 1 is manufactured.

To use the patch-type electrocardiograph 30, first, the first release sheet 19 (see the arrow and the virtual line in FIG. 4D) is peeled from the pressure-sensitive adhesive layer 2 and the probe 5.

As shown by the virtual line in FIG. 2, the adhesive lower surface 9 of the pressure-sensitive adhesive layer 2 is then brought into contact with, for example, the skin 33 of the human body. Specifically, the pressure-sensitive adhesive layer 2 is pressure-sensitively adhered to the surface of the skin 33.

Then, the probe lower surface 20 of the probe 5 comes into contact with the surface of the skin 33 by the adhesive lower surface 9 being pressure-sensitively adhered (attached) to the skin 33.

Subsequently, the probe 5 senses the action potential of the heart as an electric signal, and the electric signal sensed by the probe 5 is input to the electronic component 31 via the connection portion 6 and the wiring layer 4. The electronic component 31 processes an electric signal and stores it as information based on the electric power supplied from the battery 32. Furthermore, if necessary, the electric signal is converted into a radio wave and wirelessly transmitted to an external receiver.

In the biosensor laminate 1, as shown in FIGS. 2 and 3B, the first contact portion 61 of the connection portion 6 has a shape along the outer surface 22 of the probe 5. Therefore, the first contact portion 61 can be continuously contacted with the outer surface 22 of the probe 5. As a result, the first contact portion 61 and the outer surface 22 of the probe 5 can be stably brought into contact with each other, and the connection reliability between the connection portion 6 and the probe 5 can be improved. As a result, the connection portion 6 can reliably and electrically connect the wiring layer 4 and the probe 5.

In particular, since the size of the biosensor laminate 1 is small, alignment accuracy between the probe 5 and the connecting portion 6 is required, but since the first contact portion 61 has a shape along the outer surface 22 of the probe 5. The first contact portion 61 and the outer surface 22 of the probe 5 can be stably brought into contact with each other.

Further, when the biosensor laminate 1 is attached to the skin 33, the biosensor laminate 1 is deformed following the skin 33, so that the probe 5 and the connection portion 6 are likely to be disconnected, but the first contact is made. Since the portion 61 has a shape along the outer surface 22 of the probe 5, the connecting portion 6 and the probe 5 can be stably connected even if the biosensor laminate 1 is deformed.

Further, the probe 5 has a thin layer shape. Therefore, when the laminated body 1 for a biological sensor is attached to the surface of a biological body, it is possible to reduce the wearing feeling of the user.

Further, the first contact portion 61 has an endless shape along all of the plurality of outer surfaces 22 of the probe 5. Therefore, the first contact portion 61 can be continuously contacted with all of the plurality of outer surfaces 22 of the probe 5, and the connection reliability between the connection portion 6 and the probe 5 can be further improved.

Further, the first contact portion 61 surrounds the probe 5. Therefore, the alignment accuracy between the connecting portion 6 and the probe 5 can be improved, and the connection reliability between the connecting portion 6 and the probe 5 can be further improved.

Further, the second contact portion 62 of the connection portion 6 has the same shape as the first contact portion 61, and is arranged so as to face the first contact portion 61 in the vertical direction. Therefore, any portion of the second contact portion 62 can be brought into contact with the wiring layer 4 (first wiring 16A or second wiring 16B). As a result, the second contact portion 62 and the wiring layer 4 can be stably brought into contact with each other, and the connection reliability between the connection portion 6 and the wiring layer 4 can be improved.

Further, the connecting portion 63 of the connecting portion 6 connects the first contact portion 61 and the second contact portion 62 in the entire circumferential direction of the first contact portion 61. Therefore, even if a disconnection occurs in any portion of the connecting portion 63, the first contact portion 61 and the second contact portion 62 can be reliably and electrically connected in the other portion of the connecting portion 63. As a result, the connecting portion 6 can more reliably electrically connect the wiring layer 4 and the probe 5.

In the method for manufacturing the laminate 1 for a biosensor, as shown in FIGS. 4A to 4D, the laminate 28 including the pressure-sensitive adhesive layer 2, the base material 3, and the wiring layer 4 and the outer surface 22 of the thin-layered probe 5 After preparing the probe member 18 for supporting the probe 5 so as to be exposed, a through hole 23 having the above size is formed in the laminated body 28, and then the inner surface 23A of the through port 23 and the peripheral surface of the probe member 18 are formed. The probe member 18 is arranged in the through hole 23 so that a gap 100 facing the wiring layer 4 and the outer surface 22 of the probe 5 is formed between the wiring layer 4 and the probe 5, and then the wiring layer 4 and the probe 5 are arranged in the gap 100. An endless connection portion 6 for electrically connecting to and is formed.

The connection portion 6 formed in this way has an endless shape along the outer surface 22 of the probe 5, and has the same shape as the first contact portion 61 and the first contact portion 61 that come into contact with the outer surface 22 of the probe 5. It has a second contact portion 62 that comes into contact with the wiring layer 4, and a connecting portion 63 that connects the first contact portion 61 and the second contact portion 62.

Therefore, although it is a simple method, it is possible to improve the connection reliability between the connection portion 6 and the probe 5 and the wiring layer 4, and the connection portion 6 reliably electrically connects the wiring layer 4 and the probe 5. It is possible to smoothly manufacture the laminated body 1 for a biosensor.

Further, the probe member 18 includes the pressure-sensitive adhesive layer 2 and the base material 3, and the layer structure of the probe member 18 can be the same as the layer structure of the laminated body 28. Therefore, the flexibility of the probe member 18 can be made similar to the flexibility of the laminated body 28. As a result, it is possible to suppress the occurrence of differently flexible portions in the biological sensor laminate 1, and it is possible to reduce the wearing feeling of the user.

<Modification example>
In each of the following modifications, the same members and processes as those in the above-described embodiment are designated by the same reference numerals, and detailed description thereof will be omitted. In addition, each modification can be combined as appropriate. Further, each modification can exhibit the same effect as that of one embodiment, except for special mention.

As shown in FIG. 2, in one embodiment, the inner diameter of the first contact portion 61 is substantially the same as the diameter of the virtual circle passing through the outer surface 22 of the probe 5, and the first contact portion 61 holds the probe 5. Surrounded, but not limited to this.

As shown in FIGS. 7A and 7B, the probe 5 may be larger than the first contact portion 61 as long as the first contact portion 61 has an endless shape along the peripheral edge portion of the probe 5. Specifically, the diameter of the virtual circle passing through the outer surface 22 of the probe 5 may be larger than the outer diameter of the first contact portion 61. Further, the axis of the connecting portion 6 and the center of the probe 5 are arranged so as to overlap each other when projected in the vertical direction.

In this case, for example, the crosspiece of the crosspiece 53 located at the peripheral edge of the probe 5 is embedded in the first contact portion 61. As a result, the upper surface 53A and the side surface 53B of the crosspiece come into contact with the first contact portion 61. Therefore, even with such a modification, the connection portion 6 and the probe 5 can be electrically connected at a plurality of points.

Further, as shown in FIG. 3B, in one embodiment, the connecting portion 6 has a cylindrical shape extending in the vertical direction, and the first contact portion 61 and the second contact portion 62 having the same shape as the first contact portion 61. And a cylindrical connecting portion 63 that connects the first contact portion 61 and the second contact portion 62, but the shape and configuration of the connecting portion 6 are not limited thereto.

For example, as shown in FIG. 8A, the connecting portion 63 may be composed of a plurality of connecting columns 64 arranged at intervals in the circumferential direction of the first contact portion 61.

The plurality of connecting columns 64 connect the first contact portion 61 and the second contact portion 62 at a plurality of positions spaced apart from each other in the circumferential direction of the first contact portion 61. Each connecting pillar 64 extends in the vertical direction, the lower end portion of each connecting pillar 64 is connected to the first contact portion 61, and the upper end portion of each connecting pillar 64 is connected to the second contact portion 62. As a result, the plurality of connecting columns 64 electrically connect the first contact portion 61 and the second contact portion 62 at a plurality of positions spaced apart from each other in the circumferential direction of the first contact portion 61.

Further, as shown in FIG. 8B, the connecting portion 6 may not include the second contact portion 62 and may consist of only the first contact portion 61 and one connecting pillar 64. In this case, the upper end portion of the connecting column 64 comes into contact with the first wiring 16A (or the second wiring 16B).

Further, as shown in FIG. 8C, the second contact portion 62 may have a similar shape to the first contact portion 61. For example, the second contact portion 62 may be smaller than the first contact portion 61. In this case, the outer diameter of the second contact portion 62 is smaller than the outer diameter of the first contact portion 61, and the inner diameter of the second contact portion 62 is smaller than the inner diameter of the first contact portion 61. In this case, the connecting portion 63 has, for example, a tapered shape whose diameter becomes smaller toward the upper side. Further, the second contact portion 62 may be larger than the first contact portion 61 as long as it has a similar shape to the first contact portion 61.

Further, as shown in FIG. 8D, if the first contact portion 61 has a shape along at least a part of the entire peripheral edge portion of the probe 5, the first contact portion 61 has a plan-view endless shape instead of an endless shape. May be good. The first contact portion 61 has, for example, a substantially half-split ring shape (or a substantially half-arc shape) along a part of a virtual circle passing through the outer surface 22. Then, the first contact portion 61 comes into contact with a part of the outer surface 22 among the plurality of outer surfaces 22. The second contact portion 62 has the same plan view substantially half ring shape (or substantially semi-arc shape) as the first contact portion 61, and the connecting portion 63 has the first contact portion 61 and the second contact. The unit 62 is connected.

Also in the embodiments shown in FIGS. 8A to 8D, the connection portion 6 can reliably and electrically connect the wiring layer 4 and the probe 5.

Further, in one embodiment, as shown in FIG. 2, the probe member 18 includes the pressure-sensitive adhesive layer 2 and the base material 3, and the layer structure of the probe member 18 and the layer structure of the laminated body 28 are the same. However, the probe member 18 is not limited to this as long as it can support the probe 5, and the layer structure of the probe member 18 may be different from the layer structure of the laminated body 28.

As shown in FIG. 9, for example, the probe member 18 may consist only of the probe 5 and the support layer 55 that supports the probe 5.

In this case, the probe 5 is embedded in the lower end portion of the support layer 55 so that the lower surface 20 of the probe is exposed, and is arranged in the adhesive opening 11 of the pressure-sensitive adhesive layer 2. That is, the probe 5 is arranged on the pressure-sensitive adhesive layer 2 so that the lower surface 20 of the probe is exposed.

The support layer 55 has a cylindrical shape extending in the vertical direction and is filled inside the connection portion 6. Examples of the material of the support layer 55 include the above-mentioned resin and the like.

Further, in the manufacturing process of the laminate 1 for a biosensor, in one embodiment, as shown in FIG. 4D, the connection portion 6 is provided in the gap 100 between the inner surface 23A of the through port 23 and the peripheral surface 18A of the probe member 18. The conductive resin composition which is the material of the above is injected to form the connecting portion 6, but the method for forming the connecting portion 6 is not limited to this.

For example, as shown in FIG. 10A, a sheet (not shown) made of the material of the connecting portion 6 may be prepared, and the connecting portion 6 may be cut out from the sheet by a known punching process or the like and inserted into the gap 100. can.

Further, as shown in FIG. 10B, an integrated probe 56 including the connection portion 6 and the probe 5 integrally can be prepared, and the connection portion 6 included in the integrated probe 56 can be inserted into the gap 100. In the integrated probe 56, the first contact portion 61, which is the lower end portion of the connection portion 6, surrounds the probe 5 and is continuous with the peripheral portion of the probe 5.

Further, as shown in FIG. 11B, the probe sheet 7 including the probe 5 and the probe support portion 51 integrally can be arranged in the through port 23.

As shown in FIG. 11A, the probe sheet 7 has a sheet shape extending in the longitudinal direction and the lateral direction.

The probe support portion 51 extends radially outward from the periphery of the probe 5 and has a plate shape having no hole 52. The length (diametrical length) of the probe support portion 51 is set to be longer than the thickness direction length of the inner peripheral surface that partitions the adhesive opening portion 11 and the base material opening portion 15.

The probe sheet 7 is arranged so that the probe support portion 51 faces the through port 23, and subsequently, as shown in FIG. 11B, the crosspiece 53 (probe 5) is exposed to the through port 23. In addition to contacting the upper surface of 19, the probe support portion 51 is brought into contact with the inner peripheral surface that partitions the adhesive opening 11 and the base material opening 15, and the upper surface of the wiring layer 4 and a part of the base material upper surface 13. As a result, in the probe sheet 7, the portion in contact with the upper surface of the wiring layer 4 becomes the second contact portion 62, and the portion between the second contact portion 62 and the crosspiece 53 becomes the connecting portion 63. Further, in the probe sheet 7, a portion facing the inner peripheral surface of the probe sheet 7 facing the through hole 23 and the corner portion of the upper surface of the first release sheet 19 exposed from the through hole 23 is the first contact portion 6. Become. Further, the probe sheet 7 includes the probe 5 and the connecting portion 6 integrally.

Subsequently, a joining member 35 made of a conductive joining material is provided so as to come into contact with both the upper surface and the side surface of the second contact portion 6 and the upper surface of the wiring layer 4. As a result, the connection portion 6 is joined to the wiring layer 4 and electrically connected.

Next, the surfaces of the probe sheet 7 and the joining member 35 are covered with the adhesive sheet 36. The adhesive sheet 36 includes a support sheet 37 and an adhesive layer 38 in order in the thickness direction. Specifically, the adhesive sheet 36 is arranged on the laminated body 28 so that the adhesive layer 38 covers at least the probe 5 and the joining member 35. More specifically, the adhesive layer 38 is arranged in the probe 5, the probe support portion 51, and the joining member 35 so that the lower end portion thereof is filled in the hole 52 and the crosspiece portion 53 is embedded.

According to this aspect, the contact area of the second contact portion 62 of the probe support portion 51 with respect to the wiring layer 4 can be increased. Therefore, the connection reliability of the connection unit 6 can be further improved.

Further, as shown in FIG. 12A, a laminated body 28 not provided with the wiring layer 4 can be prepared, and the wiring layer 4, the connection portion 6, and the probe 5 can be collectively formed by, for example, an additive method or the like. (See the virtual line in FIG. 12A). In this case, the wiring layer 4, the connecting portion 6, and the probe 5 are integrally formed. Therefore, the first contact portion 61, which is the lower end portion of the connection portion 6, surrounds the probe 5 and is continuous with the peripheral portion of the probe 5.

Further, as shown in FIG. 12B, after forming the connection portion 6 in the gap 100 without providing the probe 5 in the pressure-sensitive adhesive layer 2, the probe 5 separately prepared is provided with the peripheral portion of the probe 5 on the probe upper surface 21. It can also be attached to the lower surface of the pressure-sensitive adhesive layer 2 so as to be in contact with the lower surface of the connecting portion 6.

Also according to the embodiments shown in FIGS. 10A to 12B, the biosensor laminate 1 capable of improving the connection reliability of the connection portion 6, the probe 5, and the wiring layer 4 can be smoothly manufactured.

Further, in one embodiment, as shown in FIG. 3A, the virtual line passing through the outer surface 22 of the probe 5 has a circular shape, but the shape is not particularly limited and is not shown, but is, for example, a rectangular shape. There may be. Further, the shape of the first contact portion 61 is appropriately changed according to the shape of the probe 5 so as to have a shape along at least a part of the entire peripheral edge portion of the probe 5.

Further, in one embodiment, as shown in FIG. 3A, the probe 5 has a lattice shape including a plurality of holes 52, but the shape of the probe 5 is not particularly limited, and for example, the probe 5 does not have a plurality of holes 52. It may have a flat plate shape.

Further, in one embodiment, as shown in FIG. 2, the probe 5 has a thin layer shape, but the probe 5 is not limited to this, and as shown in FIG. 13A, the probe 5 is a pressure-sensitive adhesive layer 2 and a base material. It may have a substantially columnar shape (specifically, a substantially cylindrical shape) that passes through the layer 3. The probe upper surface 21 is exposed from the upper surface of the base material 13 and the upper surface of the connecting portion 6, and is flush with the upper surface of the base material upper surface 13 and the connecting portion 6. The probe lower surface 20 is exposed from the adhesive lower surface 9 and the lower surface of the connection portion 6, and is flush with the lower surface of the adhesive lower surface 9 and the connection portion 6. The probe 5 may be an organic electrode containing a conductive resin material.

The entire outer peripheral surface of the probe 5 contacts the entire inner peripheral surface of the connecting portion 6. In this case, the inner peripheral surface 65 of the connecting portion 6 corresponds to the first contact portion in contact with the entire peripheral edge portion of the probe 5. The inner peripheral surface 65 has an endless shape along the outer peripheral surface of the probe 5 (the entire peripheral edge of the probe 5) and surrounds the probe 5. The thickness direction dimension of the inner peripheral surface 65 is, for example, 3% or more and 100% or less with respect to the entire thickness direction dimension of the connecting portion 6.

Further, in one embodiment, as shown in FIG. 2, the thickness of the probe member 18 is the same as the thickness of the laminated body 28, but the thickness of the probe member 18 is not particularly limited. As shown in FIG. 13B, for example, the thickness of the probe member 18 may be smaller than that of the laminated body 28. In this case, the connecting portion 6 may have a covering portion 66 which is arranged on the upper side of the probe member 18 and closes the upper end portion of the connecting portion 6. The covering portion 66 is connected to the entire inner peripheral surface of the second contact portion 62. The upper surface of the covering portion 66 is flush with the upper surface of the second contact portion 62 and the upper surface of the base material 13.

When the thickness of the probe member 18 is smaller than that of the laminated body 28, the connecting portion 6 may not include the covering portion 66, and the probe member 18 may be exposed from the connecting portion 6 and the base material 3.

In one embodiment, the attached electromyogram 30 is mentioned as an example of the biological sensor, but for example, a device capable of sensing the biological signal and monitoring the state of the living body can be mentioned, and specifically, the attached electromyogram 30 can be mentioned. , Stick-on sphygmomanometer, stick-on pulse rate monitor, stick-on electromyogram, stick-on thermometer, stick-on accelerometer and the like. These may be individual devices, or a plurality of devices may be incorporated in one device.

The living body includes a human body and a non-human body, and is preferably a human body.

1 Laminated body for biosensor 2 Pressure-sensitive adhesive layer 3 Base material 4 Wiring layer 5 Probe 6 Connection part 18 Probe member 28 Laminated body 61 First contact part 62 Second contact part 63 Connecting part

Claims (8)

A pressure-sensitive adhesive layer for sticking to the surface of the living body,
A base material arranged on the upper surface of the pressure-sensitive adhesive layer and
Wiring arranged on the base material and
A probe arranged on the pressure-sensitive adhesive layer so that the lower surface is exposed,
A connection portion that passes through at least the pressure-sensitive adhesive layer and connects the wiring and the probe is provided.
The connecting portion has a shape along at least a part of the entire peripheral edge portion of the probe, and is provided with a first contact portion that comes into contact with the peripheral edge portion of the probe. The laminate for a biosensor according to claim 1, wherein the probe has a thin layer shape. The laminate for a biosensor according to claim 1 or 2, wherein the first contact portion has an endless shape along the entire peripheral edge portion of the probe. The laminate for a biosensor according to claim 3, wherein the first contact portion surrounds the probe. The connection part is
A second contact portion that has the same shape or a similar shape as the first contact portion, is arranged so as to face the first contact portion in the vertical direction, and is in contact with the wiring.
The laminate for a biosensor according to any one of claims 1 to 4, further comprising a connecting portion for connecting the first contact portion and the second contact portion. The laminated body for a biosensor according to claim 5, wherein the connecting portion connects the first contact portion and the second contact portion in the entire circumferential direction of the first contact portion. A step of preparing a laminate having a pressure-sensitive adhesive layer for sticking to the surface of a living body, a base material arranged on the upper surface of the pressure-sensitive adhesive layer, and wiring arranged on the base material.
A step of preparing a probe support having a thin-layered probe and supporting the probe so that the peripheral edge of the probe is exposed, and a step of preparing the probe support.
A through hole that penetrates the laminated body in the thickness direction, and when the probe support is arranged in the through port, the wiring and the wiring and the peripheral surface of the probe support are between the inner surface of the through port and the peripheral surface of the probe support. The step of forming a through hole having a size in which a gap facing the peripheral edge of the probe is formed, and
A step of arranging the probe support in the through port so that the probe is located below the substrate and the gap is formed.
A method for manufacturing a laminate for a biosensor, which comprises a step of forming an endless connection portion for connecting the wiring and the probe in the gap. The probe support is
The pressure-sensitive adhesive layer on which the probe is placed and
The method for manufacturing a laminate for a biosensor according to claim 7, further comprising a base material arranged on the upper surface of the pressure-sensitive adhesive layer.

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