JP6973920B2 - External skin preparation - Google Patents

Description

The present invention relates to an external skin preparation.

"Collagen" is one of the major proteins that make up the extracellular matrix of the skin. It accounts for about 20% of the total protein in humans and plays an important role in the elasticity and firmness of the skin. Collagen is known to decrease with age, but it is difficult to control the amount of collagen in the skin. In cosmetics, collagen having a large molecular weight does not easily pass through the stratum corneum barrier, so it is formulated for the purpose of forming a film on the skin surface and moisturizing it. On the other hand, collagen reduced in molecular weight by hydrolysis treatment is expected to efficiently permeate the stratum corneum and exert the internal function of the skin.

Chie Mitsuhashi, Fragrance Journal, Vol.44 No.12, 38-43 (2016)

However, the external skin preparation containing collagen has a drawback that it is sticky at the time of use and does not fit well on the skin, and lacks a feeling of penetration and a feeling of moisturizing.
Therefore, it is an object of the present invention to provide a skin external preparation which is not sticky at the time of use, has good skin compatibility, and has excellent penetration and moisturizing feeling.

(1)
An external skin preparation containing the following (A) to (C).
(A) One or more selected from collagen hydrolysates and derivatives thereof, and amino acids constituting collagen and derivatives thereof (B) Quince seed extract (C) Xanthan gum (2)
The external skin preparation according to claim 1, further comprising (D) phytosterol.

The external skin preparation of the present invention has the effects of being non-sticky during use, having good skin compatibility, and having good penetration and moisturizing sensations.

Hereinafter, embodiments for carrying out the present invention will be described.

The external preparation for skin of the present invention contains (A) a collagen hydrolysate and its derivative, and one or more selected from the amino acids constituting collagen and their derivatives.

The origin of collagen for obtaining collagen hydrolysates includes animals such as cows, pigs, and birds, as well as fish, shellfish, jellyfish, and sponges, and there are problems with safety and stability, and problems with odor. From the viewpoint of productivity and economic efficiency, collagen originating from fish such as tilapia, shark, salmon, ties, and sea bass is preferable for marine organisms. The collagen hydrolyzate is a hydrolyzate obtained by hydrolyzing the above-mentioned collagen in the presence of an alkali, an acid, or an enzyme according to a conventional method. The molecular weight and degree of polymerization of the collagen hydrolyzate are not particularly limited, but the upper limit is preferably less than about 400,000 by weight average molecular weight, and the lower limit is a dipeptide.

As the peptide constituting collagen, a peptide obtained by hydrolyzing collagen to a peptide unit may be used, or a peptide obtained by synthesis may be used.

In addition, examples of the collagen derivative include the above-mentioned collagen ateloides, acylates, and succinylates, and specific examples thereof include atelocollagen, acylated collagen, and succinylated atelocollagen.

Examples of amino acids constituting collagen include glycine, proline, hydroxyproline, and alanine, which are the main constituent amino acids of collagen. Further, acetyl hydroxyproline can be exemplified as the derivative thereof.

In the present invention, when one or more selected from collagen hydrolysates and derivatives thereof, and amino acids constituting collagen and derivatives thereof are blended, the blending amount is preferably 0.001 to 2% by mass.

The external preparation for skin of the present invention contains (B) quince seed extract.

The quince seed extract is a quince seed extract and is not particularly limited as long as it can be blended with a normal external skin preparation. Water is preferable as the extraction solvent for quince seeds.

The blending amount of the quince seed extract in the external preparation for skin of the present invention is preferably 0.005 to 0.1% by mass, particularly 0.005 to 0.05% by mass, based on the total amount of the external preparation for skin as the extract pure content. preferable. If the blending amount is less than 0.005% by mass with respect to the total amount of the external skin preparation, the film feeling due to collagen cannot be sufficiently suppressed, and if the blending amount exceeds 0.1% by mass, the skin is peculiar to the polymer. It is not preferable because a film of collagen is formed and the feeling of use is impaired, and there is a problem in stability such as a gel-like change during storage.

The blending amount of the quince seed extract varies depending on the pure content of the extract and the like, but it is preferable to blend 0.01 to 1.0 mass of the quince seed extract as an extract with respect to the total amount of the external skin preparation. If the content is less than 0.01% by mass, it may not be familiar to the skin and the effect of improving the permeation feeling may not be obtained. If it is blended in excess of 1% by mass, it may cause stickiness.

(C) Xanthan gum is added to the external skin preparation of the present invention.

Xanthan gum is obtained by fermenting carbohydrates using Xanthomonas campestris to purify polysaccharides accumulated outside the cells, and is sodium of D-glucose, D-mannose and D-glucuronic acid. ， Consists of potassium and calcium salts. As the xanthan gum used in the present invention, ordinary xanthan gum may be used, or crosslinked xanthan gum which is physically crosslinked by hydrogen bonds and has a higher-order structure may be used. Regardless of the type as long as it is generally used as a raw material for external skin preparations, for example, the commercially available Echo Gum series manufactured by Dainippon Pharmaceutical Co., Ltd. and the Nomcoat series manufactured by Nisshin Oillio Group Co., Ltd. are used. Can be done. In the present invention, it is preferable to use crosslinked xanthan gum from the viewpoint of penetrating feeling.

The blending amount of xanthan gum is preferably 0.01 to 0.5% by mass. If the content is less than 0.01% by mass, the effect of improving the permeation feeling may not be recognized. If it is blended in excess of 0.5% by mass, it may cause stickiness.

By adding (D) phytosterol to the external skin preparation of the present invention, the moisturizing feeling is further improved.

Phytosterol is a general term for plant-derived sterols, and is a mixture of β-sitosterol, campesterol, stigmasterol, brassicasterol, and the like, and the type thereof is not limited. Examples of the plant of origin of such phytosterol include soybean, sunflower, rapeseed, sea buckthorn and the like, and it is preferable to use phytosterol derived from rapeseed or soybean.

In the present invention, it is preferable to use a polyhydric alcohol. Examples of such polyhydric alcohols include glycerin, diglycerin, 1,3-butylene glycol, dipropylene glycol and the like. In the external skin preparation of the present invention, the feeling of use can be adjusted by adjusting the blending amount of these polyhydric alcohols.

In addition to the above-mentioned components, the external skin preparation of the present invention can contain any components used in ordinary cosmetics and quasi-drugs to the extent that the effects of the present invention are not impaired. Specific examples thereof include oil agents, surfactants, thickeners, preservatives, fragrances, moisturizers, antioxidants, anti-inflammatory agents, antibacterial agents and the like.

The dosage form of the external skin preparation of the present invention is preferably an emulsified type, and more preferably an oil-in-water emulsified type cosmetic.

The external preparation for skin of the present invention can be prepared by a conventional method.

The external skin preparation of the present invention can be used in, for example, lotions, emulsions, and ointments.

Hereinafter, the present invention will be specifically described with reference to Examples, but this does not limit the scope of the present invention. The blending amount is mass% unless otherwise specified.

First, an evaluation method of an example and a comparative example of the present invention will be shown.

<Evaluation of stickiness>
After applying the external skin preparation of the present invention by a conventional method, it was sensually evaluated using a panel of three specialists. The stickiness of each sample of Examples and Comparative Examples after application was evaluated by discussion in the following three stages. In addition, the sensory evaluation was used in a state where the examples and the comparative examples were indistinguishable, and the evaluation was performed by the absolute evaluation. The same applies to the following sensory tests.
○: Not very sticky △: Slightly sticky ×: Very sticky

<Skin familiarity evaluation>
After applying the external skin preparation of the present invention by a conventional method, it was sensually evaluated using a panel of three specialists. Each sample of the example and the comparative example was evaluated on the following three stages by consensus on the skin familiarity after application.
○: Good skin familiarity △: Not very good skin familiarity ×: Poor skin familiarity

<Membrane feeling evaluation>
After applying the external skin preparation of the present invention by a conventional method, it was sensually evaluated using a panel of three specialists. Each sample of the example and the comparative example was evaluated in the following three stages by consensus on the film feeling after application.
○: There is just the right film feeling △: I am a little worried about the film feeling ×: I am quite worried about the film feeling

<Evaluation of moisturizing effect>
After applying the external skin preparation of the present invention by a conventional method, it was sensually evaluated using a panel of three specialists. Each sample of Example and Comparative Example was evaluated in the following four stages by discussion on the moisturizing effect after application.
◎: Very good moisturizing effect ○: Good moisturizing effect △: Not very good moisturizing effect ×: Poor moisturizing effect

Examples 1 and 2 and Comparative Examples 1 to 3 were prepared by a conventional method using the formulations shown in Table 1.

注１：加水分解コラーゲン液として魚由来、重量平均分子量約３０万の加水分解コラーゲンの０．３質量％水溶液を用いた。

Note 1: As the hydrolyzed collagen solution, a 0.3% by mass aqueous solution of hydrolyzed collagen derived from fish and having a weight average molecular weight of about 300,000 was used.

As shown in Table 1, Example 1, which is an external preparation for skin of the present invention, has no stickiness or film feeling during use, and has good skin compatibility, even though it contains a hydrolyzed collagen solution. It was a feeling of use that exerted a moisturizing effect. Further, in Example 2 in which a part of the bacillic alcohol was replaced with soybean-derived phytosterol, in addition to the feeling of use of Example 1, the feeling of use exhibiting a high moisturizing effect was obtained. On the other hand, in Comparative Examples 2 and 3 in which the xanthan gum or the quince seed extract solution was deleted and the amount of the acrylic acid / alkyl methacrylate copolymer was increased, good results were not obtained in terms of stickiness, skin compatibility and film feeling. Further, in Comparative Example 4 in which the quince seed extract solution and diglycerin were not blended, the feeling of use such as stickiness was poor, and the feeling of moisturizing effect was not felt.

Claims (2)

An external skin preparation containing the following (A) to (C) and diglycerin.
(A) 0.001 to 2% by mass of one or more selected from collagen hydrolysates.
(B) Quince seed extract as the pure extract content is 0.005 to 0.1% by mass based on the total amount of the external skin preparation.
(C) 0.01-0.5% by mass of xanthan gum The external skin preparation according to claim 1, further comprising (D) phytosterol.