JP6962909B2 - 直流電流神経伝導ブロックを伝えるための高電荷容量電極 - Google Patents
直流電流神経伝導ブロックを伝えるための高電荷容量電極 Download PDFInfo
- Publication number
- JP6962909B2 JP6962909B2 JP2018515952A JP2018515952A JP6962909B2 JP 6962909 B2 JP6962909 B2 JP 6962909B2 JP 2018515952 A JP2018515952 A JP 2018515952A JP 2018515952 A JP2018515952 A JP 2018515952A JP 6962909 B2 JP6962909 B2 JP 6962909B2
- Authority
- JP
- Japan
- Prior art keywords
- nerve
- high charge
- capacitance electrode
- charge
- charge capacitance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36062—Spinal stimulation
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Electrotherapy Devices (AREA)
Description
この出願は2015年10月6日に提出された発明の名称「直流電流神経伝導ブロックに用いられるシステム及び方法(SYSTEMS AND METHODS FOR DIRECT CURRENT NERVE CONDUCTION BLOCK)」の米国仮出願第62/237,660号の優先権を要求する。この仮出願の全内容は、すべての目的でここに援用されている。
別途定義しない限り、本明細書に使用されている全ての技術用語は、当業者が一般的に理解するものと同じ意味を有する。
本明細書に記載のとおり、用語「及び/又は」は、1つ又は複数の関連する列挙された項目の任意の及びすべての組み合わせを含み得る。
本発明は、直流(DC)神経伝導ブロックを伝えるための高電荷容量電極に関し、より具体的に、高電荷容量電極を利用してDC神経伝導ブロックを安全で伝えるシステム及び方法に関する。DC神経伝導ブロックは、発症応答を発生しないとともに、陽極の断裂を回避可能に設計可能であるため、魅力的である。しかし、DC神経伝導ブロックは、DC神経伝導ブロックを伝えるのに必要な電荷において神経障害を引き起こす可能性が非常に高い(例えば、非可逆のファラデー反応生成物を生成する)から、未だに臨床採用されていない。有利な点として、ここで記述される高電荷容量電極は、このような神経障害を回避するように設計される。以下でより詳しく説明したように、機械安定性や伝送可能な電荷量に関して、本発明の高電荷容量電極は、他のタイプの電極よりも幾つかのメリットを有する。例えば、プラチナシートが神経伝導ブロックに必要な電荷を伝送可能であるが、周知されたように、その機械性能が悪いため、表面積(さらに電荷容量)快速で著しく損失し、植込み中及び植込み後の電荷容量の不特定性を引き起こす。別例として、酸化イリジウム電極を使用し、酸化イリジウムの高容量/低インピーダンス特性を利用する。酸化イリジウムが一般的に安定であるが、酸化イリジウムの電荷蓄積容量は、相変わらず神経伝導ブロックに必要な量よりも1-2桁低い。逆に、本明細書のシステム及び方法で採用された高電荷容量電極が高電荷容量と安定な機械性質を有するため、各種の臨床や実験応用にDC神経伝導ブロックを利用可能になる。
本発明の1つの態様は、DC神経伝導ブロック(例えば、単相、平衡電荷二相、又は電荷非平衡二相)を伝えて(例えば、ブロック又は減衰)神経での伝導を変更可能なシステム10(図1)を含んでもよい。システム10は、電流を生成するための部品(例えば、電流発生器12)と、電流を神経に印加するための部品(例えば、高電荷容量電極14)とを備えてもよい。標的神経の実例は、末梢神経(例えば、運動神経、感覚神経及び/又は自律神経)及び中枢神経系(例えば、脳および/または脊髄)を含む神経又は神経組織を含み得る。DC神経伝導ブロックは、疼痛及び筋痙攣を含むがそれらに限定されない様々な神経障害を治療するために使用され得る。メリットとして、高電荷容量電極14は、(1)神経伝導ブロックの応用に必要な電荷を伝送可能であるとともに、損害を引き起こす非可逆の反応生成物の生成を回避する一方、(2)ロバストな機械性質を表し、電荷の伝送を予見可能とする。換言すれば、少なくとも高電荷容量電極14の設計と電流発生器12で生成された波形とにより、システム10は、DC神経伝導ブロックを安全で伝える。
本発明の別の態様は、DC神経伝導ブロックを神経に伝える方法30(図3)を含む。方法30は、図1に示された上記システム10によって実行され得る。メリットとして、システム10の高電荷容量電極14は、神経伝導ブロック応用に必要な電荷を伝送可能であるとともに、損害を引き起こす非可逆の反応生成物を回避し、安定な機械性質を現して予見可能に電荷を伝送する。換言すれば、方法30は、DC神経伝導ブロックを安全で伝送可能である一方、非可逆の反応生成物を生成しないため、患者の安全性を増やして臨床採用の可能性を増加させる。
以下の実例は、目的を説明するためだけであり、添付する特許請求の範囲を制限するわけではない。
YP-50カーボン活性粒子とポリフッ化ビニリデン(PVDF)とを接着剤として利用して、カーボンベース高電荷容量電極を構築する。3グラムのYP-50を6グラムのN-メチル-2- ピロリドン(NMP)に分散させる。3グラムの10wt%のPDFのNMPでの溶液を当該分散体へ加入する。得られた混合物をプラチナ箔基板(カフ電極に対して)とプラチナワイヤ(配線電極に対して)に塗布し、80℃の空気で30分間加熱してNMPを除去する。カーボンベース高電荷容量電極のプロトタイプの写真は、図4に示される。
手術により、プロトタイプカフ式と配線カーボンベース高容量電極を齧歯類動物に置いて齧歯類動物坐骨神経モデル(神経に垂直)に基づいてブロックする。配線カーボンベース高電荷容量電極(図8)とカーボンベース高電荷容量電極カフ(図9)の両者の利用により、完全な神経ブロックを実現する。
Claims (7)
- 神経における活動電位の伝達を変更するのに十分な振幅を有する直流電流(DC)を生成する電流発生器と、
前記電流発生器に結合し、且つ、非可逆のファラデー反応生成物の生成による神経障害を回避しつつ、神経伝導ブロックを達成するのに十分な総電荷を伝送するように前記DCを前記神経にある時間で印加する、高電荷容量電極とを備え、
前記高電荷容量電極は、
前記神経に接触にする基板と、
前記基板の側面に粘着される生体適合性の接着剤材料によってまとめられる活性粒子から構成されるコーティングとを含み、
前記コーティングは、DCを充放電するための電気二重層コンデンサ(EDLC)を提供し、
前記高電荷容量電極は前記EDLCの放電によって前記DCを前記神経に印加し、
前記非可逆のファラデー反応生成物は過酸化水素を含むことを特徴とするシステム。 - 前記活性粒子は、少なくとも500m 2/gの表面積を有するナノ粒子を含むことを特徴とする請求項1に記載のシステム。
- 前記ナノ粒子は、カーボンを含むことを特徴とする請求項2に記載のシステム。
- 前記ナノ粒子は、少なくとも1,000m 2/gの表面積を有することを特徴とする請求項2に記載のシステム。
- 前記DCは、ゼロ正味電荷を生成する電荷平衡の二相性波形であることを特徴とする請求項1に記載のシステム。
- 前記DCは、二相性波形であり、前記二相性波形の第2相にて、前記二相性波形の第1相で伝送された総電荷の一部を反転させることにより、神経および/または高電荷容量電極に有害となる電気化学反応を減少させることを特徴とする請求項1に記載のシステム。
- 前記高電荷容量電極は、少なくとも100mF/cm2の単位面積当たりの容量を有することを特徴とする請求項1に記載のシステム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562237660P | 2015-10-06 | 2015-10-06 | |
US62/237,660 | 2015-10-06 | ||
PCT/US2016/054663 WO2017062272A1 (en) | 2015-10-06 | 2016-09-30 | High-charge capacity electrodes to deliver direct current nerve conduction block |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2018533389A JP2018533389A (ja) | 2018-11-15 |
JP6962909B2 true JP6962909B2 (ja) | 2021-11-05 |
Family
ID=57153535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018515952A Active JP6962909B2 (ja) | 2015-10-06 | 2016-09-30 | 直流電流神経伝導ブロックを伝えるための高電荷容量電極 |
Country Status (6)
Country | Link |
---|---|
US (1) | US10828485B2 (ja) |
EP (1) | EP3359244B1 (ja) |
JP (1) | JP6962909B2 (ja) |
AU (1) | AU2016335931B2 (ja) |
CA (1) | CA2998748C (ja) |
WO (1) | WO2017062272A1 (ja) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10195434B2 (en) | 2012-06-15 | 2019-02-05 | Case Western Reserve University | Treatment of pain using electrical nerve conduction block |
WO2013188753A1 (en) | 2012-06-15 | 2013-12-19 | Case Western Reserve University | Therapy delivery devices and methods for non-damaging neural tissue conduction block |
US20150238764A1 (en) | 2013-05-10 | 2015-08-27 | Case Western Reserve University | Systems and methods for preventing noise in an electric waveform for neural stimulation, block, or sensing |
CN117482396A (zh) | 2014-08-26 | 2024-02-02 | 阿文特投资有限责任公司 | 选择性神经纤维阻断方法和系统 |
WO2017062272A1 (en) | 2015-10-06 | 2017-04-13 | Case Western Reserve University | High-charge capacity electrodes to deliver direct current nerve conduction block |
US10864373B2 (en) | 2015-12-15 | 2020-12-15 | Case Western Reserve University | Systems for treatment of a neurological disorder using electrical nerve conduction block |
US10272240B2 (en) | 2017-04-03 | 2019-04-30 | Presidio Medical, Inc. | Systems and methods for direct current nerve conduction block |
US11191974B2 (en) | 2017-05-24 | 2021-12-07 | Case Western Reserve University | Charge capacity expanding separated interface nerve electrode (SINE) |
CA3086910C (en) | 2017-12-28 | 2023-09-26 | Case Western Reserve University | Slurry electrodes for direct current nerve conduction block |
EP3755427B1 (en) * | 2018-02-20 | 2023-03-22 | Presidio Medical, Inc. | Systems for nerve conduction block |
US10940312B2 (en) | 2018-03-15 | 2021-03-09 | Avent, Inc. | Treatment kit to percutaneously block painful sensations hosted by a peripheral nerve |
US11752329B2 (en) | 2018-07-01 | 2023-09-12 | Presidio Medical, Inc. | Systems and methods for nerve conduction block |
AU2019351023B2 (en) * | 2018-09-28 | 2023-02-16 | Case Western Reserve University | Intravertebral direct current block of spinal transmission of neural signals |
US11623091B2 (en) | 2019-02-13 | 2023-04-11 | Avent, Inc. | Portable electrical stimulation system and method |
EP4257177A3 (en) * | 2019-03-15 | 2024-01-10 | Case Western Reserve University | System for accelerated recovery from direct current (dc) nerve block using repolarization |
AU2020388662A1 (en) | 2019-11-24 | 2022-06-16 | Presidio Medical, Inc. | Pulse generation and stimulation engine systems |
GB202211608D0 (en) * | 2022-08-09 | 2022-09-21 | Cambridge Entpr Ltd | Electrode, medical device, system and methods of treatmet and manufacture |
Family Cites Families (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3911899A (en) | 1973-11-08 | 1975-10-14 | Chemetron Corp | Respiration monitoring method and apparatus |
FR2283590A1 (fr) | 1974-08-30 | 1976-03-26 | Commissariat Energie Atomique | Procede de stimulation nerveuse et stimulateur d'application du procede |
US5318572A (en) * | 1992-06-02 | 1994-06-07 | Siemens Pacesetter, Inc. | High efficiency tissue stimulating and signal sensing electrode |
DE4324185A1 (de) | 1993-07-19 | 1995-01-26 | Siemens Ag | Elektrode für elektromedizinische Anwendungen |
US5401970A (en) | 1993-09-17 | 1995-03-28 | Applied Research Corporation | Biological UV-B effect monitoring instrument and method |
US6293266B1 (en) | 1998-05-26 | 2001-09-25 | A. Kayser Automotive Systems Gmbh | Exhaust gas recirculation device |
US6937904B2 (en) | 2000-12-13 | 2005-08-30 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | System and method for providing recovery from muscle denervation |
WO2002065896A2 (en) | 2001-02-20 | 2002-08-29 | Case Western Reserve University | Systems and methods for reversibly blocking nerve activity |
US7885709B2 (en) | 2001-08-31 | 2011-02-08 | Bio Control Medical (B.C.M.) Ltd. | Nerve stimulation for treating disorders |
US7778711B2 (en) | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Reduction of heart rate variability by parasympathetic stimulation |
US20070067004A1 (en) | 2002-05-09 | 2007-03-22 | Boveja Birinder R | Methods and systems for modulating the vagus nerve (10th cranial nerve) to provide therapy for neurological, and neuropsychiatric disorders |
US8073538B2 (en) | 2003-11-13 | 2011-12-06 | Cardio Polymers, Inc. | Treatment of cardiac arrhythmia by modification of neuronal signaling through fat pads of the heart |
US7486991B2 (en) | 2003-12-24 | 2009-02-03 | Cardiac Pacemakers, Inc. | Baroreflex modulation to gradually decrease blood pressure |
JP4879754B2 (ja) | 2004-01-22 | 2012-02-22 | リハブトロニクス インコーポレーテッド | 移植された非活性導電体を介して、身体組織に電流を搬送する方法 |
US20100016929A1 (en) | 2004-01-22 | 2010-01-21 | Arthur Prochazka | Method and system for controlled nerve ablation |
US8260426B2 (en) | 2008-01-25 | 2012-09-04 | Cyberonics, Inc. | Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device |
US7672727B2 (en) | 2005-08-17 | 2010-03-02 | Enteromedics Inc. | Neural electrode treatment |
US8657814B2 (en) | 2005-08-22 | 2014-02-25 | Medtronic Ablation Frontiers Llc | User interface for tissue ablation system |
US8005526B2 (en) | 2005-08-31 | 2011-08-23 | The Regents Of The University Of Michigan | Biologically integrated electrode devices |
US9913985B2 (en) | 2006-04-28 | 2018-03-13 | Second Sight Medical Products, Inc. | Method and apparatus to provide safety checks for neural stimulation |
US20070073354A1 (en) | 2005-09-26 | 2007-03-29 | Knudson Mark B | Neural blocking therapy |
AU2006306529A1 (en) | 2005-10-21 | 2007-05-03 | Purdue Research Foundation | Telemetrically controllable system for treatment of nervous system injury |
WO2007082382A1 (en) | 2006-01-23 | 2007-07-26 | Rehabtronics Inc. | Method of routing electrical current to bodily tissues via implanted passive conductors |
JP5101881B2 (ja) | 2006-02-24 | 2012-12-19 | 三菱電機株式会社 | 系統連系インバータ装置 |
US20080208300A1 (en) | 2006-06-23 | 2008-08-28 | Seertech Corporation | Ionically conductive neural bridge |
US7620453B1 (en) | 2006-10-20 | 2009-11-17 | Pacesetter, Inc. | Implantable medical device with improved EMI filter |
US7949403B2 (en) | 2007-02-27 | 2011-05-24 | Accelerated Care Plus Corp. | Electrical stimulation device and method for the treatment of neurological disorders |
US8224436B2 (en) | 2007-04-02 | 2012-07-17 | Cardiac Research, Inc. | Unidirectional neural stimulation systems, devices and methods |
WO2008140376A1 (en) | 2007-05-14 | 2008-11-20 | St. Jude Medical Ab | Tantalum electrode |
US8805510B2 (en) | 2007-08-02 | 2014-08-12 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods and systems for achieving a physiological response by pudendal nerve stimulation and blockade |
WO2009051945A1 (en) * | 2007-10-15 | 2009-04-23 | Cardiac Pacemakers, Inc. | Conductive composite electrode material |
NO2209518T3 (ja) | 2007-10-29 | 2018-07-21 | ||
GB0800797D0 (en) | 2008-01-16 | 2008-02-27 | Cambridge Entpr Ltd | Neural interface |
CA2717057A1 (en) | 2008-03-06 | 2009-09-11 | Stryker Corporation | Foldable, implantable electrode array assembly and tool for implanting same |
US8884617B2 (en) | 2008-06-23 | 2014-11-11 | The Regents Of The University Of California | Magnetic particle imaging devices and methods |
WO2010042750A2 (en) | 2008-10-09 | 2010-04-15 | Aaron David Redish | System and method for miniature wireless implantable probe |
EP3228350A1 (en) | 2009-04-22 | 2017-10-11 | Nevro Corporation | Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems and methods |
US9327070B2 (en) | 2009-04-30 | 2016-05-03 | Medtronic, Inc. | Medical device therapy based on posture and timing |
KR101143852B1 (ko) | 2009-09-23 | 2012-05-22 | 신경민 | 고주파 열치료용 rf 제너레이터의 동상 모드 노이즈 필터 |
US9174065B2 (en) | 2009-10-12 | 2015-11-03 | Kona Medical, Inc. | Energetic modulation of nerves |
US20130053922A1 (en) | 2009-10-22 | 2013-02-28 | Zaghloul Ahmed | Dipole electrical stimulation employing direct current for recovery from spinal cord injury |
US9008800B2 (en) | 2009-11-23 | 2015-04-14 | Case Western Reserve University | Separated-interface nerve electrode |
US8843188B2 (en) | 2009-11-23 | 2014-09-23 | Case Western Reserve University | Adjustable nerve electrode |
AU2010336337B2 (en) | 2009-12-23 | 2016-02-04 | Setpoint Medical Corporation | Neural stimulation devices and systems for treatment of chronic inflammation |
EP2363705B1 (en) | 2010-02-09 | 2020-01-08 | Stichting IMEC Nederland | Microfabricated liquid-junction reference electrode |
CN105477782B (zh) | 2010-03-22 | 2019-01-04 | 纽约城市大学研究基金会 | 电荷增强神经电刺激系统 |
US8401664B2 (en) | 2011-04-29 | 2013-03-19 | Cyberonics, Inc. | System and method for charging a power cell in an implantable medical device |
US8571667B2 (en) | 2011-07-01 | 2013-10-29 | Greatbatch Ltd. | Active current control using the enclosure of an implanted pulse generator |
US9566426B2 (en) * | 2011-08-31 | 2017-02-14 | ElectroCore, LLC | Systems and methods for vagal nerve stimulation |
CA2850436C (en) | 2011-09-30 | 2021-06-22 | Adi Mashiach | Apparatus and method for controlling energy delivery as a function of degree of coupling |
US9008780B2 (en) | 2011-10-05 | 2015-04-14 | Case Western Reserve University | Methods and associated neural prosthetic devices for bridging brain areas to improve function |
US9393420B2 (en) | 2012-03-09 | 2016-07-19 | Enteromedics Inc. | Safety features for use in medical devices |
DE102012010262B4 (de) | 2012-05-25 | 2014-07-03 | Albrecht Molsberger | Therapeutisch anwendbare Gleichstromabgabevorrichtung |
US10195434B2 (en) | 2012-06-15 | 2019-02-05 | Case Western Reserve University | Treatment of pain using electrical nerve conduction block |
US9694181B2 (en) * | 2012-06-15 | 2017-07-04 | Case Western Reserve University | Methods of treatment of a neurological disorder using electrical nerve conduction block |
WO2013188753A1 (en) | 2012-06-15 | 2013-12-19 | Case Western Reserve University | Therapy delivery devices and methods for non-damaging neural tissue conduction block |
US20140031905A1 (en) | 2012-07-12 | 2014-01-30 | Purdue Research Foundation | Burst pulse tissue stimulation method and apparatus |
US8781039B2 (en) | 2012-10-26 | 2014-07-15 | Deere & Company | Receiver and method for receiving a composite signal |
WO2014167063A1 (en) * | 2013-04-10 | 2014-10-16 | Sergey Shleev | Charge-storing fuel cell |
US20140324129A1 (en) | 2013-04-30 | 2014-10-30 | Case Western Reserve University | Systems and methods for temporary, incomplete, bi-directional, adjustable electrical nerve block |
US20150238764A1 (en) | 2013-05-10 | 2015-08-27 | Case Western Reserve University | Systems and methods for preventing noise in an electric waveform for neural stimulation, block, or sensing |
CA2931799C (en) * | 2013-11-27 | 2023-04-18 | The Governing Council Of The University Of Toronto | Systems and methods of enhancing electrical activation of nervous tissue |
US9707390B2 (en) | 2013-12-22 | 2017-07-18 | The Research Foundation Of The City University Of New York | Apparatus for modulation of effector organs |
KR20160105822A (ko) | 2013-12-22 | 2016-09-07 | 리서치 파운데이션 오브 더 시티 유니버시티 오브 뉴욕 | 트랜스-척추 직류 조절 시스템 |
US10758738B2 (en) | 2014-03-18 | 2020-09-01 | Case Western Reserve University | Systems and methods for fast and reversible nerve block |
US9737355B2 (en) | 2014-03-31 | 2017-08-22 | Ethicon Llc | Controlling impedance rise in electrosurgical medical devices |
CA2949566C (en) | 2014-05-23 | 2023-09-05 | Albrecht Molsberger | Therapeutically applicable multi-channel direct-current output device |
US9962547B2 (en) | 2015-02-05 | 2018-05-08 | Stimgenics, Llc | Method and apparatus for multimodal electrical modulation of pain |
AU2016215030B2 (en) | 2015-02-06 | 2020-06-18 | Nalu Medical, Inc. | Medical apparatus including an implantable system and an external system |
US20160331326A1 (en) | 2015-02-13 | 2016-11-17 | National University Of Singapore | Flexible neural strip electrodes, flexible neural ribbon electrodes and compartment based embedded nerve tissue electrode interfaces for peripheral nerves |
US10195424B2 (en) | 2015-02-20 | 2019-02-05 | The Research Foundation Of The City University Of New York | Methods and systems for treatment of spinal disorders using trans-spinal direct current stimulation |
US10039930B2 (en) | 2015-03-20 | 2018-08-07 | Stimgenics, Llc | Method and apparatus for multimodal electrical modulation of pain |
AU2016320803A1 (en) | 2015-09-08 | 2018-03-22 | Case Western Reserve University | Systems and methods for transcutaneous direct current block to alter nerve conduction |
WO2017062272A1 (en) | 2015-10-06 | 2017-04-13 | Case Western Reserve University | High-charge capacity electrodes to deliver direct current nerve conduction block |
CA3008024C (en) | 2015-12-15 | 2024-04-02 | Case Western Reserve University | Systems for treatment of a neurological disorder using electrical nerve conduction block |
US10864373B2 (en) | 2015-12-15 | 2020-12-15 | Case Western Reserve University | Systems for treatment of a neurological disorder using electrical nerve conduction block |
US10272240B2 (en) | 2017-04-03 | 2019-04-30 | Presidio Medical, Inc. | Systems and methods for direct current nerve conduction block |
CN111989036A (zh) | 2018-02-09 | 2020-11-24 | 普雷西迪奥医学有限公司 | 用于心脏传导阻滞的系统和方法 |
EP3755427B1 (en) | 2018-02-20 | 2023-03-22 | Presidio Medical, Inc. | Systems for nerve conduction block |
US11752329B2 (en) | 2018-07-01 | 2023-09-12 | Presidio Medical, Inc. | Systems and methods for nerve conduction block |
-
2016
- 2016-09-30 WO PCT/US2016/054663 patent/WO2017062272A1/en active Application Filing
- 2016-09-30 EP EP16784312.7A patent/EP3359244B1/en active Active
- 2016-09-30 CA CA2998748A patent/CA2998748C/en active Active
- 2016-09-30 AU AU2016335931A patent/AU2016335931B2/en active Active
- 2016-09-30 US US15/760,246 patent/US10828485B2/en active Active
- 2016-09-30 JP JP2018515952A patent/JP6962909B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
US20180256886A1 (en) | 2018-09-13 |
US10828485B2 (en) | 2020-11-10 |
AU2016335931A1 (en) | 2018-04-12 |
EP3359244A1 (en) | 2018-08-15 |
EP3359244B1 (en) | 2020-12-23 |
CA2998748C (en) | 2020-07-14 |
AU2016335931B2 (en) | 2019-06-27 |
CA2998748A1 (en) | 2017-04-13 |
JP2018533389A (ja) | 2018-11-15 |
WO2017062272A1 (en) | 2017-04-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6962909B2 (ja) | 直流電流神経伝導ブロックを伝えるための高電荷容量電極 | |
Larson et al. | A review for the peripheral nerve interface designer | |
Wang et al. | Self-powered direct muscle stimulation using a triboelectric nanogenerator (TENG) integrated with a flexible multiple-channel intramuscular electrode | |
AU2018249498B2 (en) | Systems and methods for direct current nerve conduction block | |
US10207106B2 (en) | Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders | |
US11752329B2 (en) | Systems and methods for nerve conduction block | |
JP2023054154A (ja) | 神経伝導ブロックのための方法およびシステム | |
Foldes et al. | Design, fabrication and evaluation of a conforming circumpolar peripheral nerve cuff electrode for acute experimental use | |
JP2012510871A (ja) | ポケット刺激を軽減した埋め込み型神経刺激装置 | |
WO2020051484A1 (en) | Peripheral nerve modulator and methods relating to peripheral nerve modulation | |
US20240198086A1 (en) | Vagal nerve stimulation for treating central nervous sytem disorders | |
US11439818B2 (en) | Electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders | |
US11191974B2 (en) | Charge capacity expanding separated interface nerve electrode (SINE) | |
RU2140301C1 (ru) | Электростимулятор желудочно-кишечного тракта | |
Thakor et al. | Bidirectional peripheral nerve interface and applications | |
US20200289817A1 (en) | Electrically anesthetizing a peripheral nerve with on-demand electrical nerve block for chronic pain management | |
Eggers et al. | Electrical block of peripheral nerves | |
Sabetian et al. | Directionally-sensitive peripheral nerve recording: Bipolar nerve cuff design | |
Giagka | Flexible active electrode arrays for epidural spinal cord stimulation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180529 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190814 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20200622 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200629 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200918 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210108 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210407 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210608 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210624 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210928 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20211014 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6962909 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |