JP6958215B2 - Valve devices and systems - Google Patents

Description

The present invention relates to valve devices and systems.

In recent years, attention has been focused on the development of μ-TAS (Micro-Total Analysis Systems) aiming at speeding up, increasing efficiency, and integration of tests in the field of in vitro diagnosis, or ultra-miniaturization of testing equipment. Active research is underway worldwide.

μ-TAS is superior to conventional inspection equipment in that it can be measured and analyzed with a small amount of sample, it can be carried, and it can be disposable at low cost.
Further, it is attracting attention as a highly useful method when an expensive reagent is used or when a small amount of a large number of samples are tested.

As the pump used for the above device, for example, a diaphragm type air pump is used in order to reduce the size (see, for example, Patent Document 1).

Japanese Unexamined Patent Publication No. 2013-163975

According to the first embodiment, a fixed portion having an internal space extending in a predetermined axial direction, a plurality of output ports arranged at intervals in the axial direction and capable of outputting a fluid of a predetermined pressure, and the above. Each of the fixed portions has an input port for inputting a fluid of a predetermined pressure, a rotating portion formed in a columnar shape extending in the axial direction and rotatably held in the internal space around the axis. Has a plurality of first connection flow paths connected to the output port including the first opening formed on the inner peripheral surface facing the internal space, and the rotating portion is the axis of the first opening. The axis line with respect to the fixed portion, including a second opening formed on the outer peripheral surface facing the internal space according to the position in the direction, each having a plurality of second connection flow paths connected to the input port. A first state in which the first opening and the second opening communicate with each other and a first state in which the first opening and the second opening do not communicate with each other according to the position of the rotating portion in the circumferential direction. A valve device in which two states are set is provided.

According to the second embodiment, the fluid device has a flow path through which the solution containing the sample substance flows, and the valve device of the first embodiment for supplying and stopping the supply of the force related to the flow of the solution. The system is provided.

The schematic perspective view of the valve device 200 which concerns on this embodiment. A side view of the valve device 200 according to the present embodiment as viewed from the + X side. FIG. 3 is a cross-sectional view of the valve device 200 according to the present embodiment. The partially enlarged view around the joint 212 which concerns on this embodiment. FIG. 3 is an enlarged partial cross-sectional view of the periphery of the rib portion 261a according to the present embodiment. The schematic block diagram which shows the pressure supply path in the valve device 200 which concerns on this embodiment. The figure which developed the rotating part 230 which concerns on this embodiment about the axis JX. The cross-sectional view which shows typically the system VS which concerns on this embodiment. The cross-sectional view which shows typically the system VS which concerns on this embodiment.

Hereinafter, embodiments of the valve device and system according to the embodiment will be described with reference to FIGS. 1 to 9. In addition, in the drawings used in the following description, in order to make the features easy to understand, the featured parts may be enlarged for convenience, and the dimensional ratio of each component may not be the same as the actual one. No.

[Valve device]
First, the valve device will be described.
FIG. 1 is a schematic external perspective view showing a part of the valve device 200 cut out.
The valve device 200 includes a fixing portion 210, a rotating portion 230, and a motor 300 (see FIG. 3).

The fixed portion 210 has a substantially rectangular parallelepiped shape extending in the axis JX direction. The fixed portion 210 has an internal space 211 penetrating in the axis JX direction. The cross-sectional shape of the internal space 211 orthogonal to the axis JX is circular. The rotating portion 230 is housed on one side of the internal space 211 in the axis JX direction. The motor 300 is housed on the other side of the internal space 211 in the axis JX direction.

In the following description, the axis JX direction, which is the length direction of the fixed portion 210, is the X direction, the thickness direction of the fixed portion 210, which is orthogonal to the X direction, is the Z direction, and is orthogonal to the X direction and the Z direction. The direction will be described as appropriate as the Y direction.

FIG. 2 is a side view of the valve device 200 as viewed from the + X side. FIG. 3 is a cross-sectional view taken along the line AA in FIG.
The fixing portion 210 has a plurality of recesses 213 (five in FIG. 3) to which the joint 212 is attached to the surface on the + Z side. The recess 213 is formed around the axis JZ orthogonal to the axis JX and parallel to the Z axis. In FIG. 2, the direction in which the output port 212 is arranged is set to 0 ° in the circumferential direction centered on the axis JX (hereinafter, simply referred to as the circumferential direction), the clockwise direction is the + side, and the counterclockwise direction is −. It will be described as appropriate on the side.

A plurality of recesses 213 are arranged at intervals along the axis J direction (five in this embodiment, only four in FIG. 1). Each recess 213 is surrounded by a side portion 213a and a bottom portion 213b. A joint 212 is airtightly fitted to the side portion 213a via a sealing material 214. When the joint 212 is attached to the recess 213, it forms a gap (shared flow path) 217 with the bottom 213b. The bottom portion 213b is formed with connection holes 215a, 215b, and 215c penetrating in the Z-axis direction at a position of 0 ° in the circumferential direction. The connection holes 215a, 215b, and 215c are sequentially arranged from the + X side at intervals in the X direction.

FIG. 4 is a partially enlarged view of the periphery of the joint 212. Since the plurality of joints 212 shown in FIG. 3 have the same configuration, FIG. 4 typically describes the periphery of the joint 212 arranged on the + X side most.
As shown in FIG. 4, the connection hole 215a forms a first opening 216a that opens to the inner peripheral surface 211a facing the internal space 211. The connection hole 215b forms a first opening 216b that opens to the inner peripheral surface 211a facing the internal space 211. The connection hole 215c forms a first opening 216c that opens to the inner peripheral surface 211a facing the internal space 211.

The joint 212 has an output port 218 to which a pipe can be connected to the outside. In the present embodiment, it is assumed that positive pressure, negative pressure, and atmospheric pressure are selectively output from the output port 218.

The first opening 216a, the connection hole 215a, and the gap 217 form a first connection flow path 219a that connects the inner peripheral surface 211a and the output port 218. The first opening 216b, the connection hole 215b, and the gap 217 form a first connection flow path 219b that connects the inner peripheral surface 211a and the output port 218. The first opening 216c, the connection hole 215c, and the gap 217 form a first connection flow path 219c that connects (communicates) the inner peripheral surface 211a and the output port 218.

That is, the gap 217 is a shared flow path that is connected to the output port 218 and is connected and shared across the first connection flow paths 219a, 219b, and 219c. In the present embodiment, positive pressure is supplied through the first connection flow path 219a, negative pressure is supplied through the first connection flow path 219b, and atmospheric pressure is supplied via the first connection flow path 219c. ..

The rotating portion 230 is formed in a columnar shape. The rotating unit 230 rotates around the axis JX by being driven by the motor 300. The rotating portion 230 has a shaft portion 240, a tubular portion 250, and a tubular portion 260 arranged coaxially with respect to the axis JX. The shaft portion 240, the cylinder portion 250, and the cylinder portion 260 are integrally rotated around the axis JX by the drive of the motor 300. The tubular portion 250 is airtightly fitted to the outer peripheral side of the shaft portion 240. The tubular portion 260 is airtightly fitted to the outer peripheral side of the tubular portion 250.

The shaft portion 240 has input ports 231 and 232 on the end face on the + X side. The input port 231 is arranged coaxially with the axis JX. The input port 232 is arranged on the outside in the radial direction with respect to the input port 231, and in FIG. 2, as an example, at a position of −45 ° in the circumferential direction.

As shown in FIG. 3, the shaft portion 240 has a cavity portion 241 and a hole portion 242, a cavity portion 243, and a hole portion 245 and a groove portion 244 and 246 shown in FIG. The cavity portion 241 is formed so as to extend in the X direction with the axis JX as the central axis. The cavity 241 is connected to the input port 231 at the end on the + X side. The −X side end of the cavity 241 is further than the first opening 216c and the connection hole 215c of the joint 212 located on the most −X side among the plurality of joints 212 arranged along the X-axis direction. It is located on the -X side. The hole portion 242 extends outward from the cavity portion 241 in the radial direction (hereinafter, simply referred to as the radial direction) centered on the axis JX, and opens on the outer peripheral surface of the shaft portion 240. The position of the hole 242 in the X direction is the same as the position where the first opening 216c and the connection hole 215c are formed in the fixing portion 210. The position of the hole 242 in the circumferential direction (hereinafter, simply referred to as the circumferential direction) around the axis JX will be described later.

The cavity portion (second cavity portion) 243 is formed so as to extend in the X direction coaxially with the input port 232 with the axis eccentric to the axis JX as the center. The cavity 243 is connected to the input port 232 at the end on the + X side. The end of the cavity 243 on the −X side is on the −X side of the first opening 216b and the connection hole 215b located on the most + X side, and from the first opening 216c and the connection hole 215c located on the most + X side. Is also located on the + X side. Since the cavity portion 243 is arranged on the + X side of the first opening portion 216c and the connection hole 215c located on the most + X side, the cavity portion 243 and the hole portion 242 do not depend on the position in the circumferential direction of the hole portion 242. Buffering is avoided.

The groove portion 244 is formed on the outer peripheral surface of the shaft portion 240 with a predetermined peripheral length in the circumferential direction. A plurality of groove portions 244 are formed at the same positions as the positions in the X direction in which the first opening portion 216b and the connection hole 215b are formed in the fixing portion 210. The length of the groove portion 244 in the circumferential direction, the position in the circumferential direction, and the number in the circumferential direction will be described later. The groove portion (fourth groove portion) 246 is formed on the outer peripheral surface of the shaft portion 240 in the axis JX direction. The groove portion 246 connects the groove portions 244 in the output ports 218 adjacent to each other in the axis JX direction. The hole portion (third hole portion) 245 extends radially outward from the cavity portion 243 and opens at the bottom of the groove portion 244. The position of the hole 245 in the circumferential direction around the axis JX will be described later.

The tubular portion 250 is formed in a cylindrical shape centered on the axis JX. The tubular portion 250 has an input port 233 on the end surface on the + X side. The input port 233 is located outside the input port 232 in the radial direction, and is arranged at a position of + 45 ° in the circumferential direction as an example in FIG. The input port 233 is arranged at a position deviated by 90 ° from the input port 232 in the circumferential direction.

The tubular portion 250 has a hollow portion 251 and a hole portion 252, 255, 256 and a groove portion 257, 258. The hole portion 252 is arranged coaxially with the hole portion 242 of the shaft portion 240. The hole 252 is formed so as to penetrate in the radial direction. The hole portion (fourth hole portion) 255 is arranged at a position facing the groove portion 244 of the shaft portion 240. The hole portion 255 is formed so as to penetrate in the radial direction.

The cavity portion (first cavity portion) 251 is formed so as to extend in the X direction coaxially with the input port 233 with the axis eccentric to the axis JX as the center. The cavity 251 is connected to the input port 233 at the end on the + X side. The end of the cavity 251 on the −X side is on the −X side of the first opening 216a and the connection hole 215a located on the most + X side, and from the first opening 216b and the connection hole 215b located on the most + X side. Is also located on the + X side. Since the cavity 251 is arranged on the + X side of the first opening 216b and the connection hole 215b located on the most + X side, buffering is avoided regardless of the position of the hole 255 in the circumferential direction. ..

The groove portion (first groove portion) 257 is formed on the outer peripheral surface of the tubular portion 250 with a predetermined peripheral length in the circumferential direction. The groove portion 257 is formed at the same position as the position in the X direction in which the first opening portion 216a and the connection hole 215a are formed in the fixing portion 210. The length of the groove portion 257 in the circumferential direction, the position in the circumferential direction, and the number in the circumferential direction will be described later. The groove portion 258 is formed on the outer peripheral surface of the tubular portion 250 in the axis JX direction. The groove portion (second groove portion) 258 connects the groove portions 257 of the output ports 218 adjacent to each other in the axis JX direction. The hole portion (first hole portion) 256 extends radially outward from the cavity portion 251 and opens at the bottom of the groove portion 257. The position of the hole 256 in the circumferential direction around the axis JX will be described later.

The tubular portion 260 is formed in a cylindrical shape centered on the axis JX. The tubular portion 260 has rib portions 261a, 261b, 261c, second openings 262a, 262b, 262c (see FIG. 5) and holes 263a, 263b, 263c.

As shown in FIGS. 1, 3 and 4, the rib portion 261a is formed at a position where the first opening 216a is formed in the X direction. The rib portion 261b is formed at a position where the first opening 216b is formed in the X direction. The rib portion 261c is formed at a position where the first opening 216c is formed in the X direction. The rib portions 261a to 261c have a semicircular shape whose cross-sectional shape bulges toward the first opening 216a to 216c (inner peripheral surface 211a of the fixing portion 210). Although a semicircular shape is exemplified as the cross-sectional shape of the rib portions 261a to 261c, the cross-sectional shape is not limited to the semicircular shape and may be another shape. The rib portions 261a to 261c are formed in an annular shape in the circumferential direction. The rib portions 261a to 261c are held by being fitted to the inner peripheral surface 211a of the fixing portion 210 at the tip portion on the outer side in the radial direction.

FIG. 5 is an enlarged partial cross-sectional view of the periphery of the rib portion 261a.
A second opening 262a is formed on the outer peripheral surface of the tip of the rib portion 261a. The second opening 262a is arranged at the same position in the X direction as the first opening 216a. The second opening 262a is formed in a groove shape extending in the circumferential direction. A hole (second hole) 263a is opened on the bottom surface of the second opening 262a. The hole portion 263a extends radially inward from the bottom surface of the second opening portion 262a and opens at a position facing the groove portion 257 of the tubular portion 250 on the inner peripheral side.

A second opening 262b is formed on the outer peripheral surface of the tip of the rib portion 261b. The second opening 262b is arranged at the same position in the X direction as the first opening 216b. The second opening 262b is formed in a groove shape extending in the circumferential direction. A hole (fifth hole) 263b is opened on the bottom surface of the second opening 262b. The hole portion 263b extends radially inward from the bottom surface of the second opening portion 262b, and is opened at a position facing the hole portion 255 of the tubular portion 250 on the inner peripheral side. The hole portion 263b is arranged coaxially with the hole portion 255.

A second opening 262c is formed on the outer peripheral surface of the tip of the rib portion 261c. The second opening 262c is arranged at the same position in the X direction as the first opening 216c. The second opening 262c is formed in a groove shape extending in the circumferential direction. A hole 263c is opened on the bottom surface of the second opening 262c. The hole portion 263c extends radially inward from the bottom surface of the second opening portion 262c and opens at a position facing the hole portion 252 of the tubular portion 250 on the inner peripheral side. The hole portion 263c is arranged coaxially with the hole portion 255 of the tubular portion 250 and the hole portion 242 of the shaft portion 240.

FIG. 6 is a schematic configuration diagram showing a pressure supply path from the input ports 231 to 233 to the output port 218 in the valve device 200. FIG. 6A shows a supply path to which positive pressure is supplied. FIG. 6B shows a supply path to which the negative pressure is supplied. FIG. 6C shows a supply path to which atmospheric pressure is supplied.

As shown in FIG. 6A, the positive pressure input from the input port 233 is supplied to the second opening 262a via the cavity 251 and the hole 256, the groove 257, and the hole 263a. The cavity portion 251, the hole portion 256, the groove portion 257, the hole portion 263a, and the second opening portion 262a form a second connection flow path 270a. The hole portion 256, the groove portion 257, and the hole portion 263a form a first relay path.

In the open state (first state) in which the second opening 262a and the first opening 216a communicate with each other, the positive pressure supplied to the second opening 262a is output via the first connection flow path 219a and the gap 217. Output to port 218. On the other hand, in the closed state (second state) in which the second opening 262a and the first opening 216a do not communicate with each other, the positive pressure supplied to the second opening 262a is not output to the output port 218. The positive pressure is supplied to the output port 218 by introducing a positive pressure fluid (for example, air) from the input port 233 into the second connection flow path 270a and the first connection flow path 219a.

As shown in FIG. 6B, the negative pressure input from the input port 232 is supplied to the second opening 262b via the cavity 243, the hole 245, the groove 244, the hole 255, and the hole 263b. NS. The hollow portion 243, the hole portion 245, the groove portion 244, the hole portion 255, the hole portion 263b, and the second opening portion 262b form a second connection flow path 270b. The hole 245, the groove 244, the hole 255 and the hole 263b form a second relay path.

In the open state (first state) in which the second opening 262b and the first opening 216b communicate with each other, the negative pressure supplied to the second opening 262b is output via the first connection flow path 219b and the gap 217. Output to port 218. On the other hand, in the closed state (second state) in which the second opening 262b and the first opening 216b do not communicate with each other, the negative pressure supplied to the second opening 262b is not output to the output port 218. The negative pressure is supplied to the output port 218 by sucking the fluid (for example, air) of the second connection flow path 270b and the first connection flow path 219b via the input port 232.

As shown in FIG. 6C, the atmospheric pressure input from the input port 231 is supplied to the second opening 262c via the cavity 241, the hole 242, the hole 252, and the hole 263c. The cavity 241 and the hole 242, the hole 252, the hole 263c, and the second opening 262c form a second connection flow path 270c. In the open state (first state) in which the second opening 262c and the first opening 216c communicate with each other, the atmospheric pressure supplied to the second opening 262c is output via the first connection flow path 219c and the gap 217. Output to port 218. On the other hand, in the closed state (second state) in which the second opening 262c and the first opening 216c do not communicate with each other, the atmospheric pressure supplied to the second opening 262c is not output to the output port 218. The supply of air to the output port 218 is performed by opening the input port 231 to the atmosphere. The second connection flow paths 270a, 270b, and 270c are provided independently of each other.

Subsequently, an example of the arrangement of the second connection flow paths 270a, 270b, and 270c including the second openings 262a, 262b, and 262c will be described.
FIG. 7 is a view in which the rotating portion 230 is developed around the axis JX. In FIG. 7, the position of the fixed portion 210 facing the first connection flow path 219a, 219b, 219c is set to an angle of 0 °. Further, in FIG. 7, the second connection flow paths 270a, 270b, and 270c in the two output ports 218 (appropriately referred to as 218A and 218B) on the + X side are shown. In FIG. 7, the hollow portion 241 arranged around the axis JX is not shown.

As shown in FIG. 7, the hollow portion 251 and the hole portion 256 for supplying positive pressure are arranged at an angle of 45 ° with respect to the tubular portion 250 as the first member in supplying positive pressure. The second opening 262a, to which the positive pressure is supplied in the second connection flow path 270a of the output port 218A, has, for example, an angle of −150 ° to −120 ° and an angle to the tubular portion 260 as the second member in the positive pressure supply. It is arranged in the range of −90 ° to 0 °. The groove portion 257 is arranged in the range of an angle of −135 ° to an angle of 80 ° so that it can be connected to the hole portion 256, 263a and the groove portion 258 described later. The hole portion 263a is arranged at a position where the second opening portion 262a and the groove portion 257 overlap each other in the radial direction.

The second opening 262a, to which positive pressure is supplied in the second connection flow path 270a of the output port 218B, has an angle of −150 ° to −120 °, an angle of −60 ° to −30 °, and an angle of 30 ° to 60, for example. It is arranged in the range of ° and angle 120 ° to 150 °. In the second connection flow path 270a of the output port 218B, the groove portion 257 has an angle of −135 ° to -25 ° and an angle of 40 ° to 140 ° so as to overlap the two second openings 262a in the radial direction. Have been placed. The groove 257 of the second connection flow path 270a of the output port 218B is connected to the groove 257 of the output port 218A by the groove 258. The groove 258 is arranged at a position in the circumferential direction that does not buffer the holes 255 and 263b for supplying negative pressure and the holes 252 and 263c for supplying atmospheric pressure. The hole 263a of the second connection flow path 270a of the output port 218B is arranged at a position where the second opening 262a and the groove 257 overlap in the radial direction.

Therefore, in the second connection flow path 270a of the output port 218A, as described with reference to FIG. 6A, the positive pressure input from the input port 233 is the hollow portion 251 and the hole portion 256, and the groove portion 257. After being supplied to the second opening 262a via the hole 263a, it can be output to the output port 218. On the other hand, in the second connection flow path 270a of the output port 218B, after the positive pressure input through the groove 257 and the groove 258 of the second connection flow path 270a of the output port 218A is supplied to the second opening 262a, It can be output to the output port 218.

The hollow portion 243 and the hole portion 245 for supplying the negative pressure are arranged at an angle of −45 ° with respect to the shaft portion 240 as the first member in the negative pressure supply. The second opening 262b, to which the negative pressure is supplied in the second connection flow path 270b of the output port 218A, has, for example, an angle of −120 ° to −90 ° and an angle to the tubular portion 260 as the third member in the negative pressure supply. It is arranged in the range of 30 ° to 180 °. The groove portion 244 is arranged in the range of an angle of −105 ° to an angle of 45 ° so that it can be connected to the hole portion 255, 263b and the groove portion 246 described later. The holes 255 and 263b are arranged at positions where the second opening 262b and the groove 244 overlap in the radial direction. The hole portion 255 is arranged in the tubular portion 250 as a second member in supplying negative pressure.

The second opening 262b, to which negative pressure is supplied in the second connection flow path 270b of the output port 218B, has an angle of −180 ° to −150 °, an angle of −90 ° to −60 °, and an angle of 0 ° to 30 as an example. It is arranged in four ranges of ° and angles 90 ° to 120 °. In the second connection flow path 270b of the output port 218B, the groove portion 244 is arranged in a range of an angle of -165 ° to −110 ° so as to overlap the four second openings 262 in the radial direction. The groove portion 246 is arranged at a position in the circumferential direction that does not buffer with the holes 242 and 252 for supplying atmospheric pressure. The hole 263b of the second connection flow path 270b in the output port 218B is arranged at a position where the second opening 262b and the groove 244 overlap in the radial direction.

Therefore, in the second connection flow path 270b of the output port 218A, as described with reference to FIG. 6B, the negative pressure input from the input port 232 is the hollow portion 243, the hole portion 245, and the groove portion 244. After being supplied to the second opening 262b via the hole 255 and the hole 263b, it can be output to the output port 218. On the other hand, in the second connection flow path 270b of the output port 218B, after the negative pressure input through the groove portion 244 and the groove portion 246 of the second connection flow path 270b of the output port 218A is supplied to the second opening 262b, It can be output to the output port 218.

As an example, the second opening 262c in which the atmospheric pressure is supplied in the second connection flow path 270c of the output port 218A is arranged in two ranges of an angle of −180 ° to −150 ° and an angle of 0 ° to 30 °. There is. Since the cavity 241 is arranged coaxially with the axis JX in the second connection flow path 270c, the holes 242, 252, which are arranged at the circumferential position of opening to the bottom of the second opening 262c and extend in the radial direction, The 263c communicates with the cavity 241 within the range of the output port 218A.

The second opening 262c to which atmospheric pressure is supplied in the second connection flow path 270c of the output port 218B has, for example, an angle of −120 ° to −90 °, an angle of −30 ° to −0 °, and an angle of 60 ° to 90. It is arranged in four ranges of ° and angles of 150 ° to 180 °. Since the cavity 241 is arranged coaxially with the axis JX in the second connection flow path 270c, the holes 242, 252, which are arranged at the circumferential position of opening to the bottom of the second opening 262c and extend in the radial direction, The 263c communicates with the cavity 241 within the range of the output port 218B.

Therefore, both the second connection flow path 270b of the output port 218A and the second connection flow path 270b of the output port 218B are input from the input port 241 as described with reference to FIG. 6 (c) above. Atmospheric pressure can be output to the output port 218 after being supplied to the second opening 262c via the cavity 241 and the hole 242, the hole 252, and the hole 263c.

In each of the above output ports 218A and 218B, since the gap 217 is a shared flow path that is connected and shared across the first connection flow paths 219a, 219b, and 219c, the second openings 262a, 262b, and 262c are shared. If two or more of them overlap in the axis JX direction, two or more of positive pressure, negative pressure, and atmospheric pressure may be mixed and supplied. In this case, since a predetermined pressure may not be supplied to the output port 218A, it is necessary not to overlap the second openings 262a, 262b, and 262c in the axis JX direction.

In the valve device 200 having the above configuration, when the rotating portion 230 is rotated around the axis JX from the position of the angle −180 ° shown in FIG. 7 to the position of the angle 180 ° by driving the motor 300, the following Pressure is supplied.

At the output port 218A, first, atmospheric pressure is supplied in the range of an angle of −180 ° to −150 °. Next, positive pressure is supplied in the range of angles −150 ° to −120 °. Next, negative pressure is supplied in the range of angles −120 ° to −90 °. Next, a positive pressure is supplied in the range of an angle of −90 ° to 0 °. Next, atmospheric pressure is supplied in the range of an angle of 0 ° to 30 °. Next, a negative pressure is supplied in the range of an angle of 30 ° to 180 °.

On the other hand, in the output port 218B, first, a negative pressure is supplied in the range of an angle of −180 ° to −150 °. Next, positive pressure is supplied in the range of angles −150 ° to −120 °. Next, atmospheric pressure is supplied in the range of angles −120 ° to −90 °. Next, negative pressure is supplied in the range of angles −90 ° to −60 °. Next, positive pressure is supplied in the range of angles −60 ° to −30 °. Next, atmospheric pressure is supplied in the range of an angle of −30 ° to 0 °. Next, a negative pressure is supplied in the range of an angle of 0 ° to 30 °. Next, a positive pressure is supplied in the range of an angle of 30 ° to 60 °. Next, atmospheric pressure is supplied in the range of angles 60 ° to 90 °. Next, negative pressure is supplied in the range of angles 90 ° to 120 °. Next, positive pressure is supplied in the range of angles 120 ° to 150 °. Next, atmospheric pressure is supplied in the range of angles 150 ° to 180 °. That is, in the output port 218B, negative pressure, positive pressure, and atmospheric pressure are sequentially and repeatedly supplied in a range of an angle of 30 °.

The timing of supplying and stopping the supply of the positive pressure, the negative pressure, and the atmospheric pressure is set by the positions of the second openings 262a, 262b, and 262c in the circumferential direction. The supply time and supply stop time of the positive pressure, the negative pressure, and the atmospheric pressure are set by the circumferential length (angle) of the second openings 262a, 262b, and 262c.
For example, assuming that the rotation speed of the rotating portion 230 is N rotations per minute, the circumferential angles θP of the second openings 262a, 262b, and 262c when positive pressure, negative pressure, and atmospheric pressure are supplied for the supply time t minutes. , Expressed by the following equation (1).
θP = 360 * N * t ... (1)
Therefore, the positions of the second openings 262a, 262b, and 262c in the circumferential direction are set according to the timing of supplying the positive pressure, the negative pressure, and the atmospheric pressure, and the length of time for supplying the positive pressure, the negative pressure, and the atmospheric pressure is set. Therefore, the lengths of the second openings 262a, 262b, and 262c in the circumferential direction may be set to the angles obtained by the equation (1).

If the rotating portion 230 is rotated in the same direction, the pipes connected to the input ports 231 to 233 may be twisted, so that a rotary connector or the like may be used, but this may lead to an increase in size and cost of the device. There is sex. Therefore, in consideration of miniaturization of the device and cost reduction, for example, after the rotating portion 230 makes one rotation (one turn), one rotation (one turn) is performed in the opposite direction to return the rotation amount to zero. Is preferable.

Further, when rotating the rotating portion 230, it may be rotated at a constant speed, for example, a small amount of constant speed step feed such as once, control of stopping at a predetermined angle for several seconds, or the like is performed. The method may be adopted.

As described above, in the valve device 200 of the present embodiment, the rotating portion 230 having the second openings 262a, 262b, and 262c to which positive pressure, negative pressure, and atmospheric pressure are supplied is rotated around the axis JX. Therefore, positive pressure, negative pressure, and atmospheric pressure are selectively output to the output port 218 at any timing and at any time according to the circumferential positions of the second openings 262a, 262b, and 262c, and the length in the circumferential direction. Can be output. Further, in the valve device 200 of the present embodiment, the output is output by arranging the second openings 262a, 262b, and 262c at different circumferential positions and circumferential lengths for each of the plurality of output ports 218A and 218B. The supply timing and supply time length of positive pressure, negative pressure, and atmospheric pressure can be set for each of the ports 218A and 218B. Therefore, in the valve device 200 of the present embodiment, when supplying a plurality of types of pressure to the pressure supply target, it is not necessary to provide a supply control device such as a solenoid valve and a control wiring for each pressure type. It is possible to suppress the increase in size and price of equipment. Further, in the valve device 200 of the present embodiment, various pressure supply patterns can be easily set by arranging the second openings 262a, 262b, and 262c for each of the plurality of output ports 218A and 218B in an arbitrary pattern. be able to.

Further, in the valve device 200 of the present embodiment, since the gap 217 in the fixed portion 210 is a shared flow path for supplying positive pressure, negative pressure, and atmospheric pressure to the output port 218, each pressure is changed. Compared with the case where the output port 218 is provided, the device can be made smaller and less expensive. In the valve device 200 of the present embodiment, even when a plurality of positive pressure supply systems are arranged with the negative pressure supply system and the atmospheric pressure supply system sandwiched between them, the positive pressure can be easily applied by the groove portion 258 connecting the groove portions 257 to each other. It can be introduced and the flow path design can be facilitated. This also applies to the negative pressure supply system in which the groove portions 244 are connected to each other by the groove portion 246.

In the valve device 200 of the present embodiment, the cross-sectional shape including the axis JX is semicircular, and the second opening 262a is at the tip of the rib portions 261a, 261b, and 261c that locally contact the inner peripheral surface 211a of the fixing portion 120. , 262b and 262c are arranged, so that the degree of sealing of the second openings 262a, 262b and 262c can be increased, and fluctuations in the pressure supplied to the output port 218 can be suppressed.

[system]
Next, the system including the pressure supply device 110 will be described with reference to FIGS. 8 and 9. In the present embodiment, a system for supplying pressure to a fluid device having a flow path by using the above-mentioned valve device 200 as a valve for opening and closing the flow path and a valve for filling the flow path with a solution will be described. ..

8 and 9 are cross-sectional views schematically showing the system VS.
The system VS includes a fluid device 100, a valve plate 170 and the valve device 200 described above.

[Fluid device]
The fluid device 100 is a device that purifies and detects a sample substance contained in a sample sample. The sample substance is, for example, a nucleic acid such as DNA or RNA, a peptide, a protein, or a biomolecule such as an extracellular endoplasmic reticulum. The fluid device 100 comprises a substrate 9 on which a flow path and a valve are formed.

The substrate 9 includes a first substrate 9A and a second substrate 9B laminated on the first substrate 9A. The flow path C is formed between the surface of the first substrate 9A facing the second substrate 9B and the sheet-shaped flow path wall 11 provided on the surface of the second substrate 9B facing the first substrate 9A. ing. The flow path C is formed between, for example, a linear recess formed on the upper surface of the first substrate 9A and the flow path wall 11. As an example of the flow path wall 11, a thermoplastic elastomer such as a polyolefin-based elastomer, a styrene-based elastomer, or a polyester-based elastomer can be exemplified.

The fluid device 100 has a valve V that opens and closes the flow path C using positive pressure and atmospheric pressure, and a moving portion M that moves the solution to the flow path C using negative pressure and atmospheric pressure. The fluid device 100 is provided with a plurality of valves V and moving portions M, respectively, and FIGS. 8 and 9 typically show the valves V and the moving portion M.

The movement of the solution by the moving unit M includes introducing the solution into the flow path C by negative pressure suction and discharging the solution from the flow path C by negative pressure suction. Discharging the solution from the flow path C by negative pressure suction includes draining the solution from the flow path C into a drainage tank provided in the fluid device 100 connected to the flow path C. The stop of introducing the solution into the flow path C and the stop of discharging the solution from the flow path C are performed by switching from the negative pressure supply to the atmospheric pressure supply.

The second substrate 9B has a recess 12a at the bottom where the valve V is arranged so that the flow path wall 11 is exposed. The upper end of the recess 12a is open. As shown in FIG. 8, the valve V sets the flow path C to the open state without deforming the flow path wall 11 in a state where the positive pressure is not supplied to the recess 12a and the atmospheric pressure is supplied. As shown in FIG. 9, the valve V elastically deforms the flow path wall 11 and bends downward in a state where a positive pressure is supplied to the recess 12a, and contacts the first substrate 9A to form a flow path C. Set to closed state.

The second substrate 9B has an exposed recess 12b that penetrates the second substrate 9B and the flow path wall 11 at a position where the moving portion M is arranged. As shown in FIG. 9, the moving portion M introduces the solution into the flow path C or from the flow path C by sucking the flow path C with the negative pressure when the negative pressure is supplied to the recess 12b. The solution of is drained.

The second substrate 9B is joined to the valve plate 170 on the upper surface.
The valve plate 170 has a hole 171 communicating with the recess 12a at a position where the valve V is arranged. The valve plate 170 has a hole 172 that communicates with the recess 12b at a position where the moving portion M is arranged.

As an example, the hole 171 corresponds to the circumferential length of the second openings 262a and 262c from the output port 218A of the valve device 200 at the timing corresponding to the circumferential position of the second openings 262a and 262c. Positive pressure and atmospheric pressure are supplied through the pipe 221 in a short time. By supplying positive pressure from the output port 218A to the hole 171, the valve V sets the flow path C to the closed state. By supplying atmospheric pressure from the output port 218A to the hole 171, the valve V sets the flow path C to the open state.

As an example, the hole 172 corresponds to the circumferential length of the second openings 262b and 262c from the output port 218B of the valve device 200 at the timing corresponding to the circumferential position of the second openings 262b and 262c. Negative pressure and atmospheric pressure are supplied through the pipe 222 in a short time. By supplying a negative pressure from the output port 218B to the hole 172, the moving portion M introduces the solution into the flow path C or drains the solution from the flow path C. By supplying atmospheric pressure from the output port 218B to the hole 172, the moving portion M stops the introduction of the solution into the flow path C or the drainage of the solution from the flow path C.

As described above, in the present embodiment system VS, when purifying / detecting the sample substance using the fluid device 100, the positive pressure, the negative pressure, and the atmospheric pressure are supplied by using the valve device 200 described above. Therefore, various pressure supply patterns can be easily set while suppressing the increase in size and price of the equipment. In the present embodiment system VS, positive pressure, negative pressure, and atmospheric pressure in which fluctuations in pressure values are suppressed are supplied to the fluid device 100, so that the sample substance is purified and detected with high accuracy using the fluid device 100. It becomes possible to do.

Although the preferred embodiments according to the present invention have been described above with reference to the accompanying drawings, it goes without saying that the present invention is not limited to the above examples. The various shapes and combinations of the constituent members shown in the above-mentioned examples are examples, and can be variously changed based on design requirements and the like within a range that does not deviate from the gist of the present invention.

For example, in the above embodiment, the valve device 200 of the present embodiment has a valve V that opens and closes the flow path C using positive pressure and atmospheric pressure, and a movement that moves a fluid to the flow path C using negative pressure and atmospheric pressure. Although the configuration applied to the fluid device 100 having the part M is illustrated, the object is not limited to the fluid device 100, and is widely applied to a system in which a predetermined process is performed using positive pressure, negative pressure, and atmospheric pressure. It is possible.

Further, in the above embodiment, the fixed portion 210 is provided with the first opening 216a, 216b, 216c which is circular and has a constant opening area, and the rotating portion 230 is provided with the second opening 262a having a peripheral length according to the pressure supply time. , 262b and 262c are provided, but the present invention is not limited to this configuration. For example, the fixed portion 210 is provided with a first opening having a peripheral length according to the pressure supply time, and the rotating portion 230 The fixed portion 210 is provided with a second opening having a constant opening area, and the fixed portion 210 is provided with a first opening having a circumference corresponding to the pressure supply time, and the rotating portion 230 is provided with a circumference corresponding to the pressure supply time. A configuration may be provided in which a long second opening is provided.

In the above embodiment, the configuration in which three types of pressures are input to the input port is illustrated, but a configuration in which two types of pressures or four or more types of pressures are input may be used.

Further, in the above embodiment, the distance between the inner peripheral surface 211a of the fixed portion 210 and the axis JX and the outer diameter of the rotating portion 230 that fits with the inner peripheral surface 211a (the tip diameters of the rib portions 261a, 261b, 261c) are determined. Although a configuration that is constant in the axis JX direction is illustrated, the configuration is not limited to this configuration. For example, the internal space 211 is formed so as to taper to the −X side in the axis JX direction, and the outer peripheral surface of the rotating portion 230 fits into the inner peripheral surface whose inner diameter decreases toward the −X side in the axis JX direction. A so-called tapered configuration may be used. By adopting this configuration, even if an error occurs in at least one of the inner diameter of the internal space 211 and the outer diameter of the rotating portion 230, the relative positions of the fixed portion 210 and the rotating portion 2301 in the axis JX direction can be adjusted. , The inner peripheral surface 211a of the fixed portion 210 and the outer peripheral surface of the rotating portion 230 can be fitted. Therefore, even if an error occurs in at least one of the inner diameter of the internal space 211 and the outer diameter of the rotating portion 230, the degree of sealing at the second openings 262a, 262b, and 262c is increased to increase the pressure supplied to the output port 218. Fluctuations can be suppressed.

100 ... Fluid device, 200 ... Valve device, 210 ... Fixed part, 211 ... Internal space, 211a ... Inner peripheral surface, 216a ... 216b, 216c ... First opening, 217 ... Gap (shared flow path), 218 ... Output port , 219a, 219b, 219c ... 1st connection flow path, 230 ... Rotating part, 231 ... 232, 233 ... Input port, 240 ... Shaft part (1st member), 243 ... Cavity part (2nd cavity part), 244 ... Groove (third groove), 245 ... Hole (third hole), 246 ... Groove (fourth groove), 250 ... Cylinder (first member), 251 ... Cavity (first cavity), 255 ... Hole (4th hole), 256 ... Hole (1st hole), 257 ... Groove (1st groove), 258 ... Groove (2nd groove), 260 ... Cylinder (2nd member, 3rd member) ), 262a, 262b, 262c ... 2nd opening, 263a ... hole (second hole), 263b ... hole (fifth hole), 270a, 270b, 270c ... second connection flow path, C ... flow Road, JX ... axis, M ... moving part, V ... valve, VS ... system

Claims (13)

A fixed portion having an internal space extending in a predetermined axial direction and a plurality of output ports arranged at intervals in the predetermined axial direction and capable of outputting a fluid of a predetermined pressure, respectively.
A rotating portion having an input port for inputting a fluid of a predetermined pressure, formed in a columnar shape extending in the axial direction, and rotatably held in the internal space around the axis.
With
The fixed portion has a plurality of first connection flow paths connected to the output port, each including a first opening formed on an inner peripheral surface facing the internal space.
The rotating portion includes a second opening formed on an outer peripheral surface facing the internal space according to the position of the first opening in the axial direction, and a plurality of second connections each connected to the input port. Has a flow path and
The first state in which the first opening and the second opening communicate with each other, and the first opening and the second opening, depending on the position of the rotating portion in the axial direction with respect to the fixing portion. A valve device in which a second state is set in which is non-communication. At least one of the first opening and the second opening is located at a position in the axial direction according to the timing of the first state, and around the axis according to the time of the first state. The valve device according to claim 1, which is arranged in length. The rotating unit has a plurality of the input ports.
The valve device according to claim 2, wherein the second connection flow path is provided independently of each other for each of the plurality of input ports. The second openings corresponding to the plurality of input ports are arranged at intervals in the axial direction.
The first opening is provided for each of the plurality of second openings corresponding to the plurality of input ports.
3. The first connection flow path includes a shared flow path that is connected to the output port and is connected and shared across a plurality of the first openings corresponding to the plurality of input ports. The valve device described in. The valve device according to claim 3, wherein the second openings corresponding to the plurality of input ports are arranged so as to be spaced apart from each other in the direction around the axis. The rotating portion includes a first member centered on the axis and a second member coaxially fitted with the outer peripheral surface of the first member and the second opening is formed on the outer peripheral surface.
The second connection flow path is a first relay path that connects a first cavity having one end connected to the input port and formed along the axial direction, and connecting the first cavity and the second opening. Including and
The first cavity portion is provided in the first member.
The first relay path is formed on the outer peripheral surface of the first member in the circumferential direction centered on the axis, and has a first position overlapping the second opening in the radial direction centered on the axis, and the circumference. The first groove portion arranged in a range including a second position different from the first position in the direction, and the first groove portion formed in the first member at the second position in the circumferential direction and extending in the radial direction. A first hole portion connecting the cavity portion and the first groove portion, and the first groove portion and the second opening portion formed in the second member at the first position in the circumferential direction and extending in the radial direction. The valve device according to any one of claims 3 to 5, which includes a second hole portion for connecting the two. A plurality of the second connection flow paths are provided at intervals in the axial direction.
The valve device according to claim 6, further comprising a second groove portion that connects the first groove portions in the adjacent second connection flow path. The rotating portion has a first member centered on the axis, a second member coaxially fitted with the outer peripheral surface of the first member, and the second member coaxially fitted with the outer peripheral surface of the second member. The opening includes, includes, and includes a third member formed on the outer peripheral surface.
The second connection flow path is a second relay path that connects a second cavity having one end connected to the input port and formed along the axial direction, and the second cavity and the second opening. Including and
The second cavity is provided in the first member.
The second relay path is formed on the outer peripheral surface of the first member in the circumferential direction centered on the axis, and has a third position overlapping the second opening in the radial direction centered on the axis, and the circumference. A third groove portion arranged in a range including a fourth position different from the third position in the direction, and the second groove portion formed in the first member at the fourth position in the circumferential direction and extending in the radial direction. A third hole that connects the cavity and the third groove, and an opening that is formed in the second member at the third position in the circumferential direction, extends in the radial direction, and faces the third groove on the inner diameter side. Then, the fourth hole portion that opens on the outer peripheral surface of the second member on the outer diameter side and the fourth hole portion and the second opening portion that are formed coaxially with the fourth hole portion in the third member are formed. The valve device according to any one of claims 3 to 7, which includes a fifth hole to be connected. A plurality of the second connection flow paths are provided at intervals in the axial direction.
The valve device according to claim 8, further comprising a fourth groove portion that connects the third groove portions in the adjacent second connection flow path. According to any one of claims 3 to 9, a fluid selected from an atmospheric pressure fluid, a fluid having a pressure higher than the atmospheric pressure, and a fluid having a pressure lower than the atmospheric pressure is input to the plurality of input ports, respectively. The described valve device. Claims 1 to claim that the inner peripheral surface of the fixed portion on which the first opening is formed and the outer peripheral surface of the rotating portion on which the second opening is formed have a shape that tapers in the axial direction. 10. The valve device according to any one of 10. A fluid device having a flow path through which a solution containing a sample substance flows,
The valve device according to any one of claims 1 to 11, which supplies and stops the supply of the force related to the flow of the solution.
System with. The force includes at least one of a positive pressure used for opening and closing or feeding the flow path and a negative pressure used for filling the flow path with the solution or discharging the solution from the flow path. Item 12. The system according to item 12.

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