JP6891173B2 - Ｂｔｋ阻害活性を有するピリミジン及びピリジン化合物を用いたｍｓの治療方法 - Google Patents

Ｂｔｋ阻害活性を有するピリミジン及びピリジン化合物を用いたｍｓの治療方法 Download PDF

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JP6891173B2
JP6891173B2 JP2018525702A JP2018525702A JP6891173B2 JP 6891173 B2 JP6891173 B2 JP 6891173B2 JP 2018525702 A JP2018525702 A JP 2018525702A JP 2018525702 A JP2018525702 A JP 2018525702A JP 6891173 B2 JP6891173 B2 JP 6891173B2
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JP2018538264A (ja
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デロベイド タミー
デロベイド タミー
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Merck Patent GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2018525702A 2015-11-17 2016-11-16 Ｂｔｋ阻害活性を有するピリミジン及びピリジン化合物を用いたｍｓの治療方法 Active JP6891173B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562256199P 2015-11-17 2015-11-17
US62/256,199 2015-11-17
PCT/US2016/062154 WO2017087445A1 (en) 2015-11-17 2016-11-16 Methods for treating multiple sclerosis using pyrimidine and pyridine compounds with btk inhibitory activity

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JP2018538264A JP2018538264A (ja) 2018-12-27
JP2018538264A5 JP2018538264A5 (OSRAM) 2019-12-26
JP6891173B2 true JP6891173B2 (ja) 2021-06-18

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US (2) US10716788B2 (OSRAM)
EP (2) EP3377484B1 (OSRAM)
JP (1) JP6891173B2 (OSRAM)
KR (1) KR102780243B1 (OSRAM)
CN (1) CN108884076B (OSRAM)
AU (1) AU2016357735B2 (OSRAM)
BR (1) BR112018007517B1 (OSRAM)
CA (1) CA3002224A1 (OSRAM)
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI858413B (zh) * 2015-11-04 2024-10-11 德商默克專利有限公司 具有ｂｔｋ抑制活性之嘧啶及吡啶化合物之用途
US10716788B2 (en) * 2015-11-17 2020-07-21 Merck Patent Gmbh Methods for treating MS using pyrimidine and pyridine compounds with BTK inhibitory activity
WO2019243223A1 (en) * 2018-06-19 2019-12-26 Merck Patent Gmbh Novel crystalline forms of 1-(4-{[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methyl}-4-fluoro-piperidin-1-yl)-propenone, salt forms thereof, and processes to obtain
JP7724151B2 (ja) * 2018-07-20 2025-08-15 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 多発性硬化症の治療及び予防方法における使用のための置換されたアミノ－ピリミジン化合物
MX2022008875A (es) 2020-01-20 2022-08-11 Genzyme Corp Inhibidores terapeuticos de tirosina quinasa para esclerosis multiple recidivante (emr).
CN112250666B (zh) * 2020-10-09 2022-01-14 广东东阳光药业有限公司 取代的嘧啶类化合物及其用途
CA3200332A1 (en) * 2020-12-02 2022-06-09 Telios Pharma, Inc. Methods and compositions for treating an ophthalmic condition
CA3201936A1 (en) 2020-12-10 2022-06-16 Minhua Chen Crystal form of tolebrutinib and preparation method thereof
US11866421B2 (en) 2021-05-31 2024-01-09 Epigen Biosciences, Inc. Pyrimidine and pyridine amine compounds and usage thereof in disease treatment
AU2023286839A1 (en) 2022-06-24 2025-02-13 Merck Patent Gmbh Treatment regimen for autoimmune diseases and inflammatory diseases
CN117986236B (zh) * 2022-11-07 2024-12-31 天津征程医药科技有限公司 氘代的嘧啶衍生物以及包含该化合物的药物组合物
WO2025096900A1 (en) * 2023-11-03 2025-05-08 Board Of Regents, The University Of Texas System Synthetic network materials and methods of making and use thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002514195A (ja) * 1996-12-05 2002-05-14 アムジエン・インコーポレーテツド 置換ピリミジン化合物およびそれの使用
WO2005095400A1 (en) 2004-03-30 2005-10-13 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of jak and other protein kinases
GB0512844D0 (en) * 2005-06-23 2005-08-03 Novartis Ag Organic compounds
EP2526934B1 (en) * 2006-09-22 2015-12-09 Pharmacyclics LLC Inhibitors of bruton's tyrosine kinase
WO2009055418A1 (en) * 2007-10-22 2009-04-30 Smithkline Beecham Corporation Pyridosulfonamide derivatives as pi3 kinase inhibitors
CA2773182A1 (en) 2009-09-10 2011-03-17 F. Hoffmann-La Roche Ag Inhibitors of jak
KR101301533B1 (ko) 2010-02-09 2013-09-04 한미사이언스 주식회사 암세포 성장 억제 효과를 갖는 신규 피리미딘 유도체
KR20180084153A (ko) * 2011-06-10 2018-07-24 메르크 파텐트 게엠베하 Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법
TW201414734A (zh) * 2012-07-10 2014-04-16 Takeda Pharmaceutical 氮雜吲哚衍生物
WO2014068527A1 (en) * 2012-11-02 2014-05-08 Pfizer Inc. Bruton's tyrosine kinase inhibitors
WO2014093230A2 (en) * 2012-12-10 2014-06-19 Merck Patent Gmbh Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity
WO2014163161A1 (ja) * 2013-04-04 2014-10-09 武田薬品工業株式会社 複素環化合物
NZ754039A (en) * 2013-06-26 2021-06-25 Abbvie Inc Primary carboxamides as btk inhibitors
RU2712220C2 (ru) * 2013-07-31 2020-01-27 Мерк Патент Гмбх Пиридины, пиримидины и пиразины в качестве ингибиторов тирозинкиназы брутона и их применение
CA2918938C (en) 2013-09-22 2021-05-18 Calitor Sciences, Llc Substituted aminopyrimidine compounds and methods of use
TWI858413B (zh) * 2015-11-04 2024-10-11 德商默克專利有限公司 具有ｂｔｋ抑制活性之嘧啶及吡啶化合物之用途
US10716788B2 (en) * 2015-11-17 2020-07-21 Merck Patent Gmbh Methods for treating MS using pyrimidine and pyridine compounds with BTK inhibitory activity

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BR112018007517B1 (pt) 2023-09-26
MX2018005463A (es) 2018-08-01
IL258978A (en) 2018-07-31
KR102780243B1 (ko) 2025-03-14
EP4295910A2 (en) 2023-12-27
EP3377484A1 (en) 2018-09-26
CA3002224A1 (en) 2017-05-26
CN108884076B (zh) 2021-07-30
US10716788B2 (en) 2020-07-21
FI3377484T3 (fi) 2023-11-30
EP3377484B1 (en) 2023-09-06
WO2017087445A1 (en) 2017-05-26
UA123159C2 (uk) 2021-02-24
RU2018120151A3 (OSRAM) 2020-03-24
HUE064244T2 (hu) 2024-02-28
BR112018007517A2 (pt) 2018-10-23
HRP20231547T1 (hr) 2024-03-15
SI3377484T1 (sl) 2024-02-29
NZ741294A (en) 2023-07-28
ZA201802348B (en) 2020-08-26
MY199473A (en) 2023-10-31
CN108884076A (zh) 2018-11-23
PH12018500736A1 (en) 2018-10-01
JP2018538264A (ja) 2018-12-27
AU2016357735A1 (en) 2018-04-26
RS64908B1 (sr) 2023-12-29
CL2018001252A1 (es) 2018-08-17
LT3377484T (lt) 2023-12-27
KR20180080243A (ko) 2018-07-11
PT3377484T (pt) 2023-12-14
AU2016357735B2 (en) 2021-01-14
IL258978B (en) 2021-04-29
RU2018120151A (ru) 2019-12-18
US20200316068A1 (en) 2020-10-08
PL3377484T3 (pl) 2024-04-08
US20170136018A1 (en) 2017-05-18
DK3377484T3 (da) 2023-11-27
MX386146B (es) 2025-03-18
EP4295910A3 (en) 2024-03-20

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