JP6890448B2 - Magnetic field data processing system - Google Patents

Description

The present invention relates to a magnetic field data processing system that processes magnetic field data acquired from a cardiac magnetic measuring device that measures a weak magnetic signal generated from the heart of a person or the like. In particular, diagnostic support for doctors to diagnose heart disease using magnetic field data, doctors and laboratory technicians present cases at case review meetings to verify treatment results, and doctors give patients symptoms Regarding data processing and explanation support functions for explaining the prognosis.

Cardiac magnetic signals generated from the hearts of adults, children, fetuses and the like are detected using a SQUID (Superconducting Quantum Interference Device) magnetometer. Unlike electric current, the magnetic field has almost the same magnetic permeability between the body and air, and information is transmitted to the outside of the body without distortion. Furthermore, since the measurement can be performed without touching the body of the subject, the spatial distribution of the electrophysiological phenomenon occurring in the heart can be accurately measured from outside the body regardless of the shape of the body. Especially in the measurement of the foetation, the magnetic field naturally generated from the foetation can be measured without touching the mother's body, which is a non-invasive and highly safe and useful measurement method.

Patent Documents 1 and 2 are available as conventional biomagnetic field observation devices using SQUID. These include a plurality of magnetometers for detecting a biomagnetic signal emitted from a living body, including a cardiomagnetic signal generated from the heart, an arithmetic processing means for performing arithmetic processing of the signal, and a means for displaying the arithmetic result. , A device for measuring the biomagnetic distribution in a magnetically shielded room is described.

Japanese Unexamined Patent Publication No. 2016-101264 Japanese Unexamined Patent Publication No. 11-104091

Patent Document 1 discloses a method for analyzing a magnetic field data of the heart, and discloses that the visibility of the data is enhanced by overwriting the magnetocardiographic data in a timely manner. Further, Patent Document 2 discloses a display method for improving the efficiency of comparison of a plurality of magnetic field data such as before and after surgery.

However, in order to explain the information obtained from the magnetocardiography including unskilled persons such as patients, an intuitively easy-to-understand magnetic field data moving image (for example, an isomagnetic field diagram is generated over time, and these are generated over time and are used on the time axis. It is considered important to utilize (which can be animated by switching and displaying above), but none of the documents describes how to improve the visibility of magnetic field data moving images.

In addition, in case study meetings, the magnetic field data of the heart is displayed on a monitor and used, but it is difficult to grasp the relationship with a specific heart part on a flat monitor. Skill is required to capture a three-dimensional image from a two-dimensional image or moving image.

An object of the present invention is to realize a cardiomagnetic measuring device and a magnetic field data processing system capable of effectively diagnosing a patient, presenting a case at a case review meeting, and explaining to the patient.

A processor, a database that stores the main memory, a magnetic field data movie, and a magnetic map corresponding to the magnetic field data movie, a magnetic field data movie display program that is read into the main memory and executed by the processor , a projection device, and a projection device. In a magnetic field data processing system having first and second display screens for displaying magnetic field data moving images, the magnetic field data moving image display program synchronizes the first magnetic field data moving image with the second magnetic field data moving image. The display screen includes a three-dimensional screen having a three-dimensional processing portion that imitates the shape of the heart, and the magnetic field data moving image display program reads a plurality of first interest times from the first magnetic diagram corresponding to the first magnetic field data moving image. reads the plurality of second interest time from second MCG corresponding to the second magnetic field data moving by Rukoto is synchronized with the plurality of first interest time and the plurality of second interest time, the first magnetic field data moving The second magnetic field data moving image is displayed on the stereoscopic screen of the first display screen on the stereoscopic screen of the second display screen in synchronization with the movement of the heart .

It is possible to effectively diagnose patients, present cases at case review meetings, and explain to patients.

It is an overview diagram of a cardiac magnetic measurement device and a magnetic field data processing system. It is a block diagram of a cardiac magnetic measurement device and a magnetic field data processing system. It is a figure which shows the appearance of the SQUID magnetic sensor. This is an example of an isomagnetic field diagram of the heart. It is a front view of a display screen. This is an example of projection on a display screen. It is a figure which shows the addition waveform of the electrocardiogram concerning the measurement data to be compared. It is a figure which shows the processing flow which synchronizes a magnetic field data moving image. This is an example of a synchronous table. It is a figure which shows the state which the content displayed on a display screen is being delivered to a smart device.

Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is an overview view showing a cardiac magnetic measurement device 1 and a magnetic field data processing system 2. In the magnetic shield room 11, a bed 13 on which the subject 12 lies and a low temperature holding device 14 are arranged. The low temperature holding device 14 contains a plurality of channels of SQUID magnetic sensors, and is filled with a refrigerant (liquid helium or liquid nitrogen) for holding the SQUID magnetic sensors in a superconducting state. The low temperature holding device 14 is mechanically held by the gantry 15. The bed 13 can move up and down and move back and forth and left and right. A measurement control device 16 is arranged outside the magnetic shield room 11. The breakdown of the measurement control device 16 will be described in detail in the description of the block diagram of FIG.

Further, the magnetic field data processing system 2 is composed of a computer 21 such as a PC (personal computer) and a printer 22, and the computer 21 uses the measurement control device 16 and the communication medium 3 to measure the magnetic field data by the cardiac magnetic measurement device 1. To give and receive. Further, when the computer 21 takes in the magnetic field data measured by the cardiac magnetic measurement device 1 from the measurement control device 16, it stores the magnetic field data in the database provided in the computer 21 and performs waveform analysis processing or the like to obtain the waveform of the measured magnetic field data. Display the analysis result on the monitor. Further, the computer 21 of this embodiment is connected to the projection device 26 in addition to the general monitor. The projection device 26 can project the magnetic field data moving image and the electrocardiogram synchronized with the magnetic field data moving image stored in the database of the computer 21 onto the display screen 25.

FIG. 2 is a functional block diagram of the cardiac magnetic measurement device 1 and the magnetic field data processing system 2. In the cardiac magnetic measurement device 1, the measurement control device 16 includes a FLL (Flux Locked Loop) circuit 17, an amplifier circuit and a filter circuit unit 18, and a database 19 for storing raw data as its main configuration.

The output from the SQUID magnetic sensor 31 installed inside the low temperature holding device 14 is input to the FLL circuit 17 that outputs a voltage proportional to the magnetic flux strength detected by the detection coil of the magnetic sensor. The FLL circuit 17 cancels the change in biomagnetism input to the SQUID via the feedback coil so as to keep the output of the SQUID constant. By converting the current flowing through the feedback coil into a voltage, a voltage output proportional to the change in the biomagnetic signal can be obtained. The voltage output is amplified and frequency band selected by the amplifier circuit and the filter circuit unit 18, and AD-converted by an AD converter (not shown), so that the voltage output is stored in the database 19 as raw magnetic field data.

The computer 21 of the magnetic field data processing system 2 has a processor 201 that loads and executes a program in the main memory 202, an interface 204 that connects to various input / output devices, and a processor 201 based on raw data from the cardiac magnetic measurement device 1. It includes a database 203 for storing the created magnetic field data moving image and other analysis results, a cardiomagnetic measuring device 1, a smart device 71, a network interface 205 for connecting to an electrocardiograph 4, and the like. Peripheral devices connected to the interface 204 include an input device 27 such as a keyboard and a mouse, a monitor 24, a printer 22, and a projection device 26. Further, the database 203 is composed of a non-volatile memory such as a hard disk drive and a flash memory.

Raw data is taken from the database 19 of the cardiomagnetic measuring device 1, the raw data is displayed on the monitor 24, and addition processing and analysis processing are performed by the processor 201 based on the operations of the doctor and the inspection engineer input from the input device 27. For example, an isomagnetic field diagram is generated from the processing result. Animated moving image data is stored in the database 203 by switching and displaying the isomagnetic field diagram generated over time on the time axis. The isomagnetic field diagram and moving image data stored in the database 203 can be displayed on the monitor 24 or projected on the display screen 25 via the projection device 26.

Further, the electrocardiogram is measured by the electrocardiograph 4 together with the measurement of the cardiac magnetism, and the electrocardiogram is taken into the computer 21 and stored in the database 203, so that the magnetic field data moving image of the heart and the electrocardiogram can be displayed in synchronization. It will be possible. The electrocardiograph 4 is a general one, and detailed description of the device configuration thereof will be omitted.

Further, in FIG. 2, the cardiac magnetic measurement device 1, the magnetic field data processing system 2, and the electrocardiograph 4 have a one-to-one relationship, but the cardiac magnetic measurement device 1, the magnetic field data processing system 2, and the heart Each of the electric meters 4 can be configured as one or a plurality of units, and there is no limit to the number of them.

FIG. 3 is a diagram showing an overview of the SQUID magnetic sensor. In the SQUID magnetic sensor kept cold in the low temperature holding device 14, a plurality of SQUID magnetic sensors 31 are spatially arranged. In the example of FIG. 3, a total of 64 8 × 8 sensors are arranged, but the number of magnetic sensors is not limited to this. By spatially arranging a plurality of SQUID magnetic sensors in this way, it is possible to create an isomagnetic field diagram of the heart from the detected cardiac magnetic signal output. FIG. 4 shows an example of an isomagnetic field diagram.

As described in Patent Document 1, the measurement of cardiac magnetism measures the external magnetic field generated by the excitement of stimulating conduction nerve cells and cardiomyocytes of the heart and the flow of an electric current. The excitement of cardiomyocytes is transmitted as an excitatory wave, and can be electrically thought of as an electric double layer gathered on the excitatory propagation wave front. Therefore, it is considered that the magnetic field generation source captured by the cardiac magnetic measurement is only the boundary portion of the electric double layer, which is the wave surface where cardiomyocytes excite and propagate. That is, it can be regarded that the magnetic field distribution created by the excitement propagation wave plane in the myocardial excitement propagation process is the isomagnetic field diagram 32 of the heart.

FIG. 5 is a front view of the display screen 25. The display screen 25 includes a three-dimensional screen 52 having a three-dimensional three-dimensional processing portion 53 imitating the shape of a heart on the right side, and a flat screen 51 on the left side. In the three-dimensional screen 52, the three-dimensional processing portion 53 has a convex shape when viewed from the front side of the screen, and the periphery of the three-dimensional processing portion 53 is deeper than the flat screen. Further, since the three-dimensional processing portion 53 has a shape that imitates the shape of the heart, it also has a side surface shape. With respect to the shape 54 from the front, the shape from the left is the shape 55, and the shape from the right is the shape 56. A projection device 26 is arranged on the back side of the display screen 25, and related data such as an electrocardiogram is synchronizedly projected from the projection device 26 together with the magnetic field data moving image of the heart.

FIG. 6 shows an example of projection on the display screen 25 shown in FIG. The magnetic field data moving image of the heart is projected on the three-dimensional processing unit 53 of the three-dimensional screen 52 on the right side of the display screen 25, and the electrocardiogram is projected on the flat screen 51 on the left side, and the time line 59 is displayed at the time position synchronized with the moving image on the right side. It shows the state of doing. Note that FIG. 6 shows an example in which three types of electrocardiographic waveforms are displayed on the flat screen 51, but the present invention is not limited to this. As for the electrocardiogram, a method called "12-lead electrocardiogram" in which the electrocardiographic waveforms of 12 types of leads are simultaneously measured is generally used clinically, and among these, a characteristic lead suitable for each case is appropriately selected, for example. It is desirable to select "lead V2", "lead V5", "lead II", etc. so that they can be displayed. It is assumed that these electrocardiographic waveforms can be freely switched by the presenter, for example, at the time of presentation by reproducing the magnetic field data moving image of the heart at a case study meeting, regardless of before or during the reproduction of the moving image.

What is projected on the three-dimensional processing section 53 of FIG. 6 is an isomagnetic field diagram and an arrow map. In each case, the maps obtained over time are animated and displayed. The isomagnetic field diagram has been described with reference to FIG. 4, but is colored so that the magnetic strength can be intuitively understood. For example, the maximum magnetic field is red, the minimum magnetic field is blue, and the middle is yellow, and the color tone is changed between them so that they are displayed so as to gradually change. The arrow map shows the direction and direction of the electric current in order to show the flow of the electric current in the heart, which is the cause of the magnetic field. Since it can be calculated from the same raw data, it is possible to display the isomagnetic field diagram and the arrow map as a superposed moving image.

By projecting such a magnetic field data moving image onto the three-dimensional processing unit 53 of the three-dimensional screen 52, it is possible to obtain an effect that the positional relationship between the heart portion and the magnetic field data can be easily grasped as compared with the two-dimensional display. To further enhance its effectiveness, images of the heart can be occasionally inserted and projected, or still images of the heart can be temporarily superimposed and projected. In this case, as the image of the heart, it is possible to use an actual image of the heart of the patient obtained and generated by a known ultrasonic examination technique, a known radiation tomography technique, or the like, instead of a general-purpose common image. desirable. The timing of projecting the image of the heart may be at regular time intervals, or may be projected according to the peak of each waveform. Make it possible to project appropriately so that the positional relationship between the heart part and the magnetic field data movie can be easily grasped.

By the way, in presentations at case review meetings and explanations to patients, the measurement time is different, such as comparison between before and after treatment in the same patient, and comparison between immediately after treatment and 3 years after treatment2. You may want to display two measurement data at the same time and compare them. However, it is unlikely that the heartbeat timing and the appearance timing of the waveform will match in the measurement data before and after the comparison target. Therefore, even if two display screens 25 are installed to display each of them, it is difficult to compare them because the operation timings of the hearts of both are different. Therefore, if the two magnetic field data moving images to be displayed can be displayed in synchronization with the movement of the heart, it will be easy to compare them. Therefore, in the magnetic field data processing system, the magnetic field data moving image display program is stored in the non-volatile storage unit of the computer 21 so that the two magnetic field data moving images can be displayed in synchronization with each other. The program is read into the main memory 202 of the computer 21 and executed by the processor 201.

For this synchronization, the time of interest of the magnetocardiogram is used. FIG. 7 shows the magnetocardiographic data (additional waveform) to be compared. Both data 35 and 36 are in the state before synchronization, but the computer 21 automatically corrects and displays both magnetic field data moving images so that the given interest times (maximum 5 times) are synchronized with each other.

The time of interest is a term that indicates the start / end time of each waveform appearing in the electrocardiogram. And Toff65 records the end of the T wave. The P wave is a waveform showing atrial excitation (contraction), the QRS complex is ventricular excitation (contraction), that is, depolarization of the ventricular muscle, and the T wave is ventricular repolarization. Therefore, these times of interest correspond to the contraction and expansion of the heart. The time of interest is given to the graph displayed on the monitor 24 of the magnetic field data processing system 2 by a doctor or an inspection engineer who measures the magnetic field meter, or is given by an automatic giving function provided in the magnetic field data processing system 2. Further, these interest times are stored and stored together with the measurement data in the database 203 of the magnetic field data processing system 2. For example, the data before and after the treatment are both taken out and used for synchronization between the measurement data acquired at different times. Can be done.

FIG. 8 shows a processing flow for synchronizing the magnetic field data moving image corresponding to the added waveform 35 and the magnetic field moving image data corresponding to the added waveform 36. Further, FIG. 9 shows an example of a synchronization table 80 required for synchronizing measurement data with each other in the processing flow of FIG. The following will be described along with the processing flow of FIG.

First, the measurement data to be compared is read out (S101). Here, it is the addition waveform 35 and the addition waveform 36 shown in FIG. The time of interest of these added waveforms always occurs in the above order. However, depending on factors such as cases, some waves may not be detected and the corresponding time of interest may not be assigned. In this example, it is assumed that each of the added waveforms is given five time of interest. As a result, the respective interest times are registered in the rows 81 and 83 of the synchronization table 80.

Next, the synchronization time setting method is selected (S102). For example, "adjust to the time of interest before treatment (" addition waveform 35 "in this example)", "adjust to the time of interest after treatment ("addition waveform 36 "in this example)", or "adjust to the middle before and after treatment". There can be a method such as. Therefore, it is desirable to display these options on the monitor 24 so that the user (presenter) can select one of these methods. Options other than these may be provided.

Next, the section length is calculated for each of the addition waveform 35 and the addition waveform 36 (S103). The section lengths of each added waveform are shown in FIGS. 7 and 9. For example, the section length from the start of the addition waveform 35 to Pon is T1 (= t1-0), and the section length from the start of the addition waveform 36 to Pon is T6 (= t6-0). If there is an interest time not given as described above, ignore it and compare. For example, if the interest time Poff is not assigned to any of the added waveforms, the section length from Pon to QRSon is calculated, and the subsequent processing is performed.

Next, the synchronization time is calculated according to the selected synchronization time setting method (S104). For example, for the synchronization time Pon, t11 = t1 if the method is "adjust to the time of interest before treatment", t11 = t6 if the method is "adjust to the time of interest after treatment", and "adjust to the middle before and after treatment". In the case of the method, t11 = (t1 + t6) / 2.

Next, with respect to the calculated synchronization time, the synchronization time interval lengths T11 to T15 (row 86 of the synchronization table 80) are calculated in the same manner as in step S103 (S105).

Finally, the expansion / contraction ratio of the magnetic field data moving image on the time axis is obtained for each section from the section length of the addition waveform 35, the section length of the addition waveform 36, and the synchronization time section length (S106). The magnetic field data moving image corresponding to the added waveform 35 is referred to as the magnetic field data moving image 1, and the magnetic field data moving image corresponding to the added waveform 36 is referred to as the magnetic field data moving image 2. For example, in the section from the start to Pon, the expansion / contraction ratio of the magnetic field data moving image 1 is T11 / T1, and the expansion / contraction ratio of the magnetic field data moving image 2 is T11 / T6. The same is required for other sections.

In this way, with the function of synchronizing the two magnetic field data videos, the presenter of the case study group can see the difference in the heartbeat timing and heartbeat interval before and after the treatment of the case, and the waveform appearance timing depending on the treatment result and the course of the prognosis. You can make a presentation to the audience by pausing the playback at any time at the point to be compared without worrying about such things. Further, this function is not limited to the case where two sets of display screens 25 are displayed side by side. Even when only one set of display screens 25 can be prepared, for example, when switching between pre-treatment and post-treatment data and displaying the data, the synchronization function enables switching at the same timing appropriately.

Although application examples related to data comparison before and after treatment have been described so far, it is assumed that the display screens are arranged side by side for each direction in which the magnetic field data of the heart is measured and displayed at the same time. The magnetic field data of the heart is generally measured from three directions, "front", "side", and "back". If the device is not capable of measuring these at the same time, there is a possibility that magnetic field data obtained by measuring magnetic field data from three directions at the same date and time for the same patient can be compared and examined at the same time. In this function of simultaneously displaying measurement data from three directions, a plurality of sets of display screens 25 can be arranged and the synchronization function described above can be applied to synchronously display a plurality of magnetic field data moving images. Further, the magnetic field data moving images from three directions may be combined and displayed on one display screen (three-dimensional screen).

Furthermore, as a function specialized for operation at the case study meeting, a magnetic field data processing system having a smart device utilization function will be described. FIG. 10 shows a state in which the same content as the screen projected on the display screen 25 is delivered to the smart device 71 held by the listener at the case review meeting. Further, on the display screen 25 and the smart device 71, a comment screen 72 is displayed in which the presenter or the like fills in and displays a key event or the like. Furthermore, in order to set a level for the listeners of the case review meeting, a "general listener" is set at the lower level, and a "commentator" or "instructor" is set at the upper level, so that the range that can be operated by the smart device 71 is different. , It is desirable to make a difference in access rights.

FIG. 10 shows a state in which the listener of the case review meeting displays the contents of the display screen 25 on the smart device 71 at hand and opens the comment screen 72 to display the comment. In the presentation of the case study meeting, it is assumed that the presenter pauses the magnetic field data movie playing at the characteristic point and explains what kind of phenomenon is occurring at the point. The presenter registers the character string to be displayed on the comment screen 72 in advance, but may be added or changed at the time of presentation. In addition, it shall be possible to display or cancel as many times as necessary. The minutes creator of the case review meeting and the listeners of the presentation have the smart device 71, and the presenter of the case review meeting pauses the playback of the video, and the listeners explain the reason and the information to be explained at that time. It is displayed on the comment screen 72 of the smart device 71 of the smart device 71. Audiences who have a predetermined access right can use the screen of the smart device 71 as a still image and save it as an attachment to the minutes or as a teaching material.

Shooting with the smart device 71 is not limited to a still image, but may be a moving image. Further, it is desirable that the comment screen 72 can control display availability, movement of the display position, and change of size for each smart device 71.

Furthermore, listeners with a higher level of access rights can perform remote control such as video playback and pause on the smart device 71, and even edit and display comments. As a result, the upper-level user can remotely control the magnetic field data processing system 2 by using the smart device 71 from the same viewpoint as the listener, away from the computer 21, so that an effective presentation can be made.

If wearable devices such as eyeglasses are further generalized, it is possible to display the same display as in FIG. 10 on such wearable devices. In this case, a known line-of-sight detection technique is applied to enable hands-free operation.

By utilizing such smart devices and wearable devices, it is possible to effectively carry out diagnosis by a doctor, presentation of a case at a case review meeting by a doctor or a laboratory engineer, and explanation to a patient by a doctor.

1: Magnetic measurement device, 2: Magnetic field data processing system, 3: Communication medium, 4: Electrocardiograph, 11: Magnetic shield room, 12: Subject, 13: Bed, 14: Low temperature holding device, 15: Gantry , 16: Measurement control device, 17: FLL circuit, 18: Amplifier circuit and filter circuit unit, 19: Database, 21: Computer, 22: Printer, 24: Monitor, 25: Display screen, 26: Projection device, 27: Input Device, 31: SQUID magnetic sensor, 32: isomagnetic field diagram, 71: smart device.

Claims (7)

With the processor
Main memory and
A database that stores the magnetic field data movie and the magnetocardiogram corresponding to the magnetic field data movie,
A magnetic field data moving image display program that is read into the main memory and executed by the processor ,
Projector and
It has first and second display screens for displaying the magnetic field data moving image by the projection device .
The magnetic field data moving image display program displays the first magnetic field data moving image and the second magnetic field data moving image in synchronization with each other.
The display screen includes a three-dimensional screen having a three-dimensional processing portion that imitates the shape of the heart.
The magnetic field data moving image display program reads a plurality of first interest times from the first magnetic field diagram corresponding to the first magnetic field data moving image, and a plurality of second interests from the second magnetic field diagram corresponding to the second magnetic field data moving image. reads a time, by Rukoto synchronize the plurality of first interest time and the plurality of second interest time, the first magnetic field data video to the stereoscopic screen of the first display screen, the second magnetic field A magnetic field data processing system that displays a data moving image on the three-dimensional screen of the second display screen in synchronization with the movement of the heart. In claim 1,
It has an input device for inputting a synchronization setting method for synchronizing the first magnetic field data moving image and the second magnetic field data moving image.
As the synchronization setting method, at least, it is synchronized with the time of interest of the first magnetic field data movie, the time of interest of the second magnetic field data movie, or the time of interest of the first magnetic field data movie and the second magnetic field data. synchronizing the middle of interest time video, a plurality settings, follow the any selected plurality set by the input device, the magnetic field data moving picture display program, the said first magnetic field data moving the 2 Magnetic field data A magnetic field data processing system that displays moving images in synchronization with moving images. In claim 1 ,
A magnetic field data processing system that inserts an image of the heart applied to the magnetic field data moving image displayed on the three-dimensional processing unit of the three-dimensional screen into the magnetic field data moving image, or temporarily superimposes and projects the image. In claim 1 ,
The display screen has a flat screen and
The electrocardiogram corresponding to the magnetic field data moving image is stored in the database.
A magnetic field data processing system that synchronizes the electrocardiogram corresponding to the magnetic field data moving image displayed on the three-dimensional processing unit and displays it on the flat screen. In claim 4 ,
A magnetic field data processing system that delivers the contents displayed on the display screen to smart devices. In claim 5 ,
A magnetic field data processing system that includes a comment field in the display content of the display screen. In any one of claims 1 to 6,
The magnetic field data moving image is an isomagnetic field diagram created over time from a cardiac magnetic signal measured by a cardiac magnetic measuring device that measures the cardiac magnetism generated from the subject's heart by a plurality of magnetic sensors on the time axis. A magnetic field data processing system that is animated by switching and displaying with.

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