JP6865427B2 - Electrode sheet and its manufacturing method - Google Patents

Description

The present invention relates to an electrode sheet capable of acquiring a biological signal of a living body by being in close contact with the living body, and a method for manufacturing the same.

Conventionally, it has been used for diagnosis and treatment by acquiring and analyzing biological signals (brain wave signals, heartbeat signals, etc.) of a living body. The acquisition of this biological signal is performed by attaching an electrode to the living body, and the acquired biological signal is transmitted to the analyzer.

As an electrode attached to a living body, an electrode arranged on a flat silicon resin sheet is known. However, it is difficult for the entire sheet to maintain complete contact with tissues such as the brain, which have a complicated shape and a large curvature. Therefore, it is difficult to obtain stable contact between the electrode and the living body for a long period of time, which hinders long-term indwelling in the living body for recording. Therefore, an electrode sheet capable of bringing an electrode into close contact with a living body has been proposed (see, for example, Patent Document 1).

Japanese Unexamined Patent Publication No. 2011-30678

In the proposed electrode sheet, a net-like flexible substrate is used as the sheet. Since a plurality of voids are provided by making the sheet reticulated, we have succeeded in fitting the electrodes to a living body such as the brain, which is complicated and has a large curvature.

By the way, when the electrode sheet is brought into close contact with a living body, it is necessary to determine a position for acquiring a biological signal and to bring the electrode sheet into close contact with the position. In the proposed electrode sheet, it was difficult to position the electrode with respect to the living body due to the flexibility of the flexible substrate. Therefore, an electrode sheet that is easy to position and is in close contact with the living body is more useful.

An object of the present invention is to provide an electrode sheet that is easy to position and is in close contact with a living body.

The present invention is an electrode sheet capable of acquiring a biological signal of the living body by being in close contact with the living body, and the sheet-shaped flexible substrate, wiring formed along the surface of the flexible substrate, and the wiring. The support sheet comprises an electrically connected measurement terminal and a support sheet superposed on the flexible substrate, and the support sheet relates to an electrode sheet formed of a material that is softened by heat transmitted from a living body.

Further, the support sheet may sandwich the wiring between the flexible substrate and the support sheet.

The support sheet may have a first through hole through which the measurement terminal is inserted, and the entire wiring may be sandwiched between the flexible substrate and the support sheet.

Further, the electrode sheet of the present invention may further include the wiring, the support sheet, and a sealing layer for sealing the flexible substrate.

Further, the electrode sheet of the present invention may further include a coating layer that covers the sealing layer and is formed of a material that is less invasive than the sealing layer.

Further, the sealing layer has a second through hole communicating with the first through hole, the coating layer has a third through hole communicating with the second through hole, and the measurement terminal has the first through hole. One through hole, the second through hole, and the third through hole may be inserted.

Further, the measurement terminal may be formed so as to protrude from the surface of the coating layer.

Further, the electrode sheet of the present invention may further include an adhesive layer formed of a gel-like material on the front end side surface of the measurement terminal.

Further, the flexible substrate and the coating layer may be formed of a material having a transmittance that allows the wiring to be visually recognized.

Further, the present invention is a method for manufacturing an electrode sheet capable of acquiring a biological signal of the living body by being in close contact with the living body, and is a wiring forming step of forming a plurality of wirings along the surface of a sheet-shaped flexible substrate. A wiring sandwiching step of sandwiching a plurality of the wirings using the flexible substrate and the support sheet by superimposing the support sheet formed of a material softened by heat transmitted from the living body on the flexible substrate. A first through hole forming step of forming one first through hole for each wiring at an arbitrary position along the wiring from the exposed surface of the support sheet in the thickness direction, and inside the first through hole. The present invention relates to a method for manufacturing an electrode sheet, comprising a measurement terminal forming step of forming a measuring terminal electrically connected to the wiring.

According to the present invention, it is possible to provide an electrode sheet that is easy to position and is in close contact with a living body.

It is a top view which shows the electrode sheet which concerns on one Embodiment of this invention. It is a perspective view which shows the region A of FIG. It is sectional drawing BB of FIG. The perspective view of the flexible substrate of the electrode sheet which concerns on one Embodiment is shown. The perspective view of the electrode sheet which formed the wiring on the flexible substrate which concerns on one Embodiment is shown. The perspective view of the electrode sheet which superposed the support sheet on the flexible substrate which concerns on one Embodiment is shown. The perspective view of the electrode sheet which formed the sealing layer on the flexible substrate which concerns on one Embodiment is shown. A perspective view of an electrode sheet in which a coating layer is formed on a flexible substrate and a sealing layer according to an embodiment is shown. The perspective view of the electrode sheet which formed the 2nd through hole in the coating layer and the sealing layer which concerns on one Embodiment is shown.

Hereinafter, an embodiment of the electrode sheet and the method for manufacturing the electrode sheet according to the present invention will be described with reference to FIGS. 1 to 9.
The electrode sheet 1 according to the present embodiment is used as an inspection (analysis) sheet to be embedded in a living body. For example, as shown in FIG. 1, the electrode sheet 1 is configured such that a plurality of wirings 20, 20, ... Are arranged side by side in one direction of the sheet surface, and one end side of the wiring 20 is connected to the analysis device 2. Used by. By arranging the other end side of the wiring 20 in close contact with the brain of the living body, for example, an electroencephalogram (biological signal) of the living body can be acquired. The analysis device 2 can analyze and analyze the acquired brain waves in order to obtain information useful for diagnosing the state of the living body, treatment, and the like.

Instead of the analysis device 2, a wireless module capable of wireless communication with the analysis device 2 can be connected to one end side of the wiring 20. As described above, by using the wireless module, the electrode sheet 1 and the wireless module can be placed in the living body to continuously acquire brain waves. Moreover, it can be used not only for acquisition of electroencephalogram but also for acquisition of pulse, electrocardiogram, and the like.

As shown in FIGS. 2 and 3, such an electrode sheet 1 is adhered to a flexible substrate 10, a wiring 20, a support sheet 30, a measurement terminal 40, a sealing layer 50, and a coating layer 60. The agent layer 70 is provided.
The flexible substrate 10 is formed in a sheet shape using, for example, parylene. In this embodiment, the flexible substrate 10 is formed with a thickness of 3 μm.

The wiring 20 is formed linearly using, for example, silver nanowires, and is formed along the surface of the flexible substrate 10. In the present embodiment, the wiring 20 is formed in a plate shape. A plurality of wirings 20 are provided, and as shown in FIG. 1, they are arranged side by side in a state where the stretching directions are aligned. In the present embodiment, such wirings 20 are arranged at intervals of 300 μm.

The measurement terminal 40 is formed of, for example, silver, and as shown in FIG. 3, is formed so as to bulge from the surface of the wiring 20 and is integrated with the wiring 20. As a result, the measurement terminal 40 is electrically connected to the wiring 20. Then, as shown in FIG. 3, the tip of the measuring terminal 40 in the bulging direction is formed in a hemispherical shape. One such measurement terminal 40 is provided for each of the plurality of wirings 20, and is formed so as to bulge from the surface at an arbitrary position on the wiring 20 according to the measurement position of the living body.

The support sheet 30 is formed by using an acrylic copolymer such as a copolymer of octadecyl acrylate and butyl acrylate, and is particularly formed by a material that is softened by heat transferred from a living body. In addition, in this embodiment, softening means that by displacing along the unevenness of the surface of the living body, it becomes flexible to the extent that it can be adhered. Such a support sheet 30 is arranged so as to be overlapped with the flexible substrate 10. As a result, the support sheet 30 sandwiches the wiring 20 between the flexible substrate 10 and the wiring 20. Further, the support sheet 30 has a first through hole 31 through which the measurement terminal 40 is inserted, and the entire wiring 20 is sandwiched between the flexible substrate 10 and the support sheet 30.

Regarding the flexible substrate 10, the wiring 20, the measurement terminal 40, and the support sheet 30 as described above, the support sheet 30 has rigidity before being brought into close contact with the living body. As a result, the handling of the electrode sheet 1 can be facilitated, and the positioning of the electrode sheet 1 at the measurement position of the living body can be facilitated. Then, the support sheet 30 is softened by the heat transferred from the living body. By bringing the electrode sheet 1 into close contact with the measurement position of the living body, the flexible substrate 10 and the support sheet 30 can be deformed according to the shape of the living body (for example, the surface shape of the brain). Since the wiring 20 can be curved according to the deformation of the flexible substrate 10 and the support sheet 30, the measurement terminal 40 can be brought into close contact with the measurement position of the living body. As a result, the biological signal can be acquired at the measurement terminal 40 electrically connected to each of all the wirings 20.

The sealing layer 50 is formed using, for example, parylene, and seals the wiring 20, the support sheet 30, and the flexible substrate 10. The sealing layer 50 is formed, for example, with a thickness of 1 μm. Further, the sealing layer 50 has a second through hole 51 that communicates with the first through hole 31, and the measurement terminal 40 is inserted into the second through hole 51.

The coating layer 60 covers the sealing layer 50 and is formed of a material that is less invasive than the sealing layer 50. Such a coating layer 60 is formed using, for example, poly (3-methoxypropyl acrylate). Further, the coating layer 60 has a third through hole 61 that communicates with the second through hole 51, and the measurement terminal 40 is inserted into the third through hole 61 and protrudes from the surface of the coating layer 60.

The adhesive layer 70 is formed of a gel-like material on the tip-side surface of the measurement terminal 40 (on the surface exposed from the coating layer 60). The adhesive layer 70 is formed using, for example, polyvinyl alcohol.

According to the sealing layer 50, the coating layer 60, and the adhesive layer 70 as described above, the support sheet 30, the wiring 20, and the flexible substrate 10 can be sealed by the sealing layer 50. It is possible to prevent the sheet 30 from being displaced with respect to the position of the wiring 20, and also to prevent the support sheet 30 and the wiring 20 from being damaged by an impact or the like applied from the outside. Further, since the coating layer 60 is in close contact with the living body when the electrode sheet 1 is in close contact with the living body, the influence of the flexible substrate 10 and the sealing layer 50 on the living body can be reduced as compared with the influence on the living body. Then, the adhesive layer 70 can enhance the adhesion between the measurement terminal 40 and the living body. In addition, a stable biological signal can be obtained by increasing the adhesion between the measurement terminal 40 and the living body.

Then, according to the measurement terminal 40, the support sheet 30, the sealing layer 50, and the coating layer 60 as described above, the measurement terminal 40 has the first through hole 31, the second through hole 51, and the first through hole 31. By inserting the three through holes 61, the support sheet 30, the sealing layer 50, and the coating layer 60 can be inserted, and the bulging side tip can be projected (exposed) from the coating layer 60. As a result, the measurement terminal 40 can acquire a biological signal even if the sealing layer 50 and the coating layer 60 are formed. In particular, the measuring terminal 40 protrude from the surface of the coating layer 60, and, since the bulging side tip portion is formed in a hemispherical shape, the measurement position of the living body with the contact to the living body of the covering layer 60 It is easily pressed and adheres, and a biological signal can be obtained satisfactorily.

Next, a method for manufacturing the electrode sheet 1 will be described.
The method for manufacturing the electrode sheet 1 includes a wiring forming step, a wiring sandwiching step, a first through hole forming step, a sealing layer forming step, a coating layer forming step, a second through hole forming step, and a third through hole forming step. It includes a hole forming step, a measuring terminal forming step, and an adhesive layer forming step.
In the wiring forming step, a plurality of wirings 20, 20, ... Are formed along the surface of the sheet-shaped flexible substrate 10 prepared as shown in FIG. The plurality of wirings 20, 20, ... By plating silver nanowires with gold, spray-coating parylene, and then scraping the surface of the flexible substrate 10 by laser etching to arrange the spray-coated silver nanowires. It is formed.

In the wiring sandwiching step, a plurality of wirings 20 are sandwiched between the flexible substrate 10 and the support sheet 30 by superimposing the support sheet 30 on the flexible substrate 10. In the present embodiment, in the wiring sandwiching step, the entire surface of each of the plurality of wirings 20 is sandwiched by using the flexible substrate 10 and the support sheet 30.

In the first through hole forming step, one first through hole 31 is formed for each wiring 20 at an arbitrary position along the wiring 20 from the exposed surface of the support sheet 30 in the thickness direction. In the present embodiment, in the first through hole forming step, the first through holes 31 are formed at different distances from the edge of the flexible substrate 10 in the extending direction of the wiring 20.

In the sealing layer forming step, as shown in FIG. 7, the wiring 20, the support sheet 30, and the flexible substrate 10 are sealed to form the sealing layer 50. As a result, the sealing layer 50 seals the wiring 20, the support sheet 30, and the flexible substrate 10, including the opening of the first through hole 31 formed in the support sheet 30.

Next, in the coating layer forming step, as shown in FIG. 8, the entire surface of the flexible substrate 10 and the sealing layer 50 is coated. Then, as shown in FIG. 9, the second through hole forming step forms the second through hole 51 that penetrates the sealing layer 50 in the thickness direction. Further, in the third through hole forming step, the third through hole 61 that penetrates the coating layer 60 in the thickness direction is formed. In the second through-hole forming step and the third through-hole forming step, the second through-hole 51 and the third through-hole 61 are formed according to the opening positions of the first through-hole 31. As a result, the first through hole 31, the second through hole 51, and the third through hole 61 are formed so as to communicate with each other.

The measurement terminal forming step forms the measurement terminal 40 electrically connected to the wiring 20. Specifically, the measurement terminal 40 is formed by filling the inside of the first through hole 31, the second through hole 51, and the third through hole 61 with silver by printing or the like. As a result, as shown in FIG. 3, the measurement terminal 40 is integrally formed with the wiring 20 and bulges from the surface of the wiring 20 and protrudes from the surface of the coating layer 60 by the hemispherical tip portion. Formed into a shape. Further, as shown in FIG. 6, the measurement terminal 40 can be formed at an arbitrary position for each wiring 20 along the extending direction of the wiring 20, so that it is versatile according to various organs of the living body. It is possible to provide an electrode sheet 1 having a high value.
In the adhesive layer forming step, the adhesive layer 70 is formed by applying a gel-like material to the front end side surface of the measurement terminal 40.

The electrode sheet 1 as described above is used as follows.
First, the electrode sheet 1 before being brought into close contact is in a state of high rigidity as a whole due to the high rigidity of the support sheet 30. Such an electrode sheet 1 is aligned with a measurement position of a living body for measuring a biological signal. Then, when the electrode sheet 1 is in close contact with the measurement position of the living body, the heat of the living body is transferred to the support sheet 30. The support sheet 30 is softened by the heat transferred from the living body. As a result, the electrode sheet 1 can be brought into close contact with the unevenness of the living body (for example, the surface shape of the brain).

When the electrode sheet 1 is in close contact with the living body, the tip of the measurement terminal 40 can also be in close contact with the living body. Adhesive layer 70 formed on the tip portion on the surface of the measuring terminal 40, the adhesive effect to a living body, measuring terminal 40 is prevented from being detached from the living body. In this way, the electrode sheet 1 can acquire a biological signal from a living body.

According to the electrode sheet 1 of the present embodiment, the electrode sheet 1 can be arranged between the skull and the brain by using the rigidity of the support sheet 30. The electrode sheet 1 is inserted between the skull and the brain and is positioned at the measurement position of the living body. Then, the electrode sheet 1 is softened by the heat transferred from the living body and adheres to the surface of the living body. Since the electrode sheet 1 is fixed at the measurement position by the pressure between the skull and the brain, the electroencephalogram of the living body can be satisfactorily acquired without the electrode sheet 1 shifting.

According to the electrode sheet 1 of one embodiment and the manufacturing method thereof described above, the following effects are obtained.

(1) An electrode sheet 1 capable of acquiring a biological signal is provided by a sheet-shaped flexible substrate 10, wiring 20 formed along the surface of the flexible substrate 10, and a support sheet 30 superimposed on the flexible substrate 10. Configured. Then, the support sheet 30 was formed of a material that is softened by the heat transferred from the contacted living body. As a result, since the support sheet 30 before coming into contact with the living body is not softened, it is possible to easily align the measurement terminal 40 with respect to the measuring position of the living body. Then, when the electrode sheet 1 comes into contact with the living body, the support sheet 30 is softened by the heat from the living body. As a result, the electrode sheet 1 can be deformed according to the surface shape of the living body at the measurement position and can be brought into close contact with the living body. As a result, the wiring 20 can be aligned with the surface of the living body, and the measurement terminal 40 can be brought into close contact with the living body, so that a more accurate electric signal can be obtained from the living body.

(2) The support sheet 30 is configured to sandwich the wiring 20 with the flexible substrate 10. As a result, the support sheet 30 and the flexible substrate 10 can protect the wiring 20 from external impacts and the like.

(3) A through hole is formed in the support sheet 30 through which the measurement terminal 40 is inserted. Then, the support sheet 30 sandwiches the entire wiring 20 between the flexible substrate 10 and the flexible substrate 10. As a result, regardless of the position of the surface of the measurement terminal 40 with respect to the wiring 20, the support sheet 30 sandwiches the entire wiring 20 with the flexible substrate 10 in a non-softened state. be able to. Therefore, it is possible to prevent the acquisition of the biological signal at an erroneous place, which is generated when the wiring 20 comes into contact with the living body. Further, since the entire wiring 20 is supported by the support sheet 30 before softening, it is possible to prevent the wiring 20 from bending before the alignment, and the alignment can be made easier.

(4) The electrode sheet 1 was further composed of a wiring 20, a support sheet 30, and a sealing layer 50 for sealing the flexible substrate 10. As a result, it is possible to prevent the support sheet 30 from being displaced with respect to the position of the wiring 20, and it is possible to prevent the support sheet 30 and the wiring 20 from being damaged by an impact or the like applied from the outside.

(5) The sealing layer 50 was coated, and a coating layer 60 formed of a material less invasive than the sealing layer 50 was further formed. As a result, when the electrode sheet 1 is in close contact with the living body, the coating layer 60 is in close contact with the living body, so that the influence of the sealing layer 50 on the living body can be reduced as compared with the influence on the living body.

(6) The sealing layer 50 was formed with a second through hole 51 communicating with the first through hole 31, and the covering layer 60 was formed with a third through hole 61 communicating with the second through hole 51. Then, the measurement terminal 40 is formed so as to insert the first through hole 31, the second through hole 51, and the third through hole 61. As a result, the measurement terminal 40 penetrates the support sheet 30, the sealing layer 50, and the coating layer 60. Therefore, since the tip of the measurement terminal 40 is exposed from the surface of the coating layer 60, the biological signal can be satisfactorily obtained from the measurement position of the living body.

(7) The measurement terminal 40 is formed so as to protrude from the surface of the coating layer 60. As a result, when the coating layer 60 is in close contact with the living body, the measurement terminal 40 is pressed against the living body. Thereby, the biological signal can be satisfactorily acquired from the measurement position of the living body.

(8) An adhesive layer 70 formed of a gel-like material was provided on the surface on the tip side of the measurement terminal 40. As a result, the adhesion between the measurement terminal 40 and the living body can be improved, and even if the measurement terminal 40 deviates from the measurement position of the living body, the biological signal can be acquired. In addition, a stable biological signal can be obtained by increasing the adhesion between the measurement terminal 40 and the living body.

(9) The method for manufacturing the electrode sheet 1 includes a wiring forming step of forming a plurality of wirings 20 along the surface of the flexible substrate 10, a wiring sandwiching step of sandwiching the wirings 20 between the flexible substrate 10 and the support sheet 30. Each wiring 20 is composed of a first through hole forming step of forming one first through hole 31 in the support sheet 30 and a measuring terminal forming step of forming a measuring terminal 40 in the first through hole 31. Thereby, the formation positions of the first through hole 31 and the measurement terminal 40 formed in the wiring 20 can be changed according to the use of the electrode sheet 1. Therefore, it is possible to provide a highly versatile electrode sheet 1 for various organs.

Although the electrode sheet of the present invention and a preferred embodiment of the method for producing the electrode sheet have been described above, the present invention is not limited to the above-described embodiment and can be appropriately modified.
For example, the flexible substrate 10 and the coating layer 60 are preferably formed of a material having a visible transmittance for the wiring 20. As a result, when aligning the electrode sheet 1 with the living body, the alignment can be performed while confirming the position of the wiring 20.

Further, in the above embodiment, the measurement terminal 40 is formed by using silver printing, but the present invention is not limited to this. For example, the measurement terminal 40 may be formed by filling the first through hole 31, the second through hole 51, and the third through hole 61 with a material in which silver nanowires are dispersed in polyvinyl alcohol.

Further, in the above embodiment, the electrode sheet 1 has been described as a sheet for acquiring electroencephalograms, but the present invention is not limited to this. For example, the electrode sheet 1 may be used as a sheet for acquiring an electrocardiogram or muscle movement as an electric signal by being in close contact with the heart, or a sheet for acquiring movement as an electric signal by being in close contact with internal organs or the like. May be used as.

Further, in the above embodiment, the measurement terminal 40 has a first through hole 31, a second through hole 51, and a third through hole 61 that penetrate the support sheet 30, the sealing layer 50, and the coating layer 60. It was formed by insertion. On the other hand, the measurement terminal 40 may be formed so as to penetrate the sealing layer 50 and the covering layer 60 from the surface of the wiring 20 opposite to the surface overlapped with the support sheet 30.

Further, although the adhesive layer 70 is provided in the above embodiment, the adhesive layer 70 may not be provided as long as sufficient adhesion to the living body can be ensured. By providing the adhesive layer 70, stable impedance can be obtained on the low frequency side of the brain wave.

Further, in the above embodiment, the support sheet 30 is said to be overlapped on the entire surface of the wiring 20, but the present invention is not limited to this. For example, the support sheet 30 may be overlapped with a part of the wiring 20. In short, the support sheet 30 may be superposed on the plurality of wirings 20 so that the flexible substrate 10 and the wirings 20 can be maintained so as not to be curved until the electrode sheet 1 is brought into close contact with the measurement position of the living body.

Further, the coating layer 60 may be formed by using the materials shown in 1) to 8) below.
1) A homopolymer of a monomer containing a unit containing an ether structure such as a polyalkylene oxide unit such as a polyethylene oxide unit or a polypropylene oxide unit and an ethylenically unsaturated double bond such as a vinyl group, or a monomer containing the monomer. A polymer having an alkyl main chain and a side chain containing an ether structure, which is a copolymer obtained by using a monomer mixture.
2) A polymer that is a type of betaine that maintains electrical neutrality in a biological environment and has an alkyl main chain and a side chain containing a phospholipid polar group.
3) A polymer containing an ether structure at the end of a side chain and containing a repeating unit derived from (meth) acrylamide.
4) A polymer containing a structure capable of containing water molecules in a state called "intermediate water" observed in a biological substance.
5) PEO-PPO-PEO triblock copolyether comprising polyethylene oxide unit-polypropylene oxide unit-polyethylene oxide unit.
6) 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, polyethylene glycol (PEG), poly (2-methoxyethyl acrylate) (PMEA), polyalkoxyalkyl (meth) acrylamide, polyvinylpyrrolidone (PVP), and poly (2-). One or more polymers selected from the group consisting of hydroxyethyl methacrylate) (PHEMA).
7) Poly (2-methacryloyloxyethyl phosphorylcholine) unit, polyethylene oxide unit, poly (2-methoxyethyl acrylate) unit, polyalkoxyalkyl (meth) acrylamide unit, polyvinylpyrrolidone unit, and poly (2-hydroxyethylmethacrylate) unit. A polymer containing one or more units selected from the main chain or side chain.
8) One or more selected from the group consisting of 2- (meth) acrylamide-2-methyl-propanesulfonic acid, vinyl sulfate, allyl sulfate, styrenesulfonic acid, sulfoethyl (meth) acrylate, and sulfopropyl (meth) acrylate. A polymer that is a homopolymer of a monomer having a sulfonic acid group or a copolymer obtained by using a monomer mixture containing a monomer having a sulfonic acid group.

Further, as the support sheet 30, a polymer having an acrylic acid system can be used.

Further, the first through hole 31 may have a diameter larger than that of the second through hole 51 and the third through hole 61. This makes it possible to prevent the material of the support sheet 30 from seeping out from the first through hole 31.

1 Electrode sheet 10 Flexible substrate 20 Wiring 30 Support sheet 31 First through hole 40 Measurement terminal 50 Sealing layer 51 Second through hole 60 Coating layer 61 Third through hole 70 Adhesive layer

Claims (10)

An electrode sheet capable of acquiring the biological signal of the living body by being in close contact with the living body.
Sheet-shaped flexible substrate and
Wiring formed along the surface of the flexible substrate and
A measurement terminal that is electrically connected to the wiring
A support sheet superimposed on the flexible substrate and
With
The support sheet is an electrode sheet formed of a material that is softened by heat transmitted from a living body. The electrode sheet according to claim 1, wherein the support sheet sandwiches the wiring between the flexible substrate and the flexible substrate. The electrode sheet according to claim 2, wherein the support sheet has a first through hole through which the measurement terminal is inserted, and the entire wiring is sandwiched between the flexible substrate and the flexible substrate. The electrode sheet according to claim 3, further comprising the wiring, a support sheet, and a sealing layer for sealing the flexible substrate. The electrode sheet according to claim 4, further comprising a coating layer that covers the sealing layer and is formed of a material that is less invasive than the sealing layer. The sealing layer has a second through hole that communicates with the first through hole, and has a second through hole.
The coating layer has a third through hole that communicates with the second through hole, and has a third through hole.
The electrode sheet according to claim 5, wherein the measurement terminal is inserted through the first through hole, the second through hole, and the third through hole. The electrode sheet according to claim 5 or 6, wherein the measurement terminal is formed so as to project from the surface of the coating layer. The electrode sheet according to any one of claims 5 to 7, further comprising an adhesive layer formed of a gel-like material on the surface on the tip end side of the measurement terminal. The electrode sheet according to any one of claims 5 to 8, wherein the flexible substrate and the coating layer are formed of a material having a transmittance that allows the wiring to be visually recognized. A method for manufacturing an electrode sheet capable of acquiring a biological signal of the living body by being in close contact with the living body.
A wiring forming process for forming a plurality of wirings along the surface of a sheet-shaped flexible substrate, and
A wiring sandwiching step in which a plurality of the wirings are sandwiched between the flexible substrate and the support sheet by superimposing a support sheet formed of a material softened by heat transmitted from a living body on the flexible substrate.
A first through hole forming step of forming one first through hole for each wiring at an arbitrary position along the wiring from the exposed surface of the support sheet in the thickness direction.
A measurement terminal forming step of forming a measurement terminal electrically connected to the wiring in the first through hole,
A method for manufacturing an electrode sheet.

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