JP6849730B2 - 自己完結型モジュラー分析カートリッジ及びプログラム可能試薬送達システム - Google Patents
自己完結型モジュラー分析カートリッジ及びプログラム可能試薬送達システム Download PDFInfo
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Description
項101/86.1:x1=インキュベーション、x2=四角、x3=丸、x4=インキュベーション、x5=三角、x6=丸。
項102/86.2:x1=星、x2=インキュベーション、x3=インキュベーション、x4=インキュベーション、x5=星、x6=三角。
項103/86.3:x1=丸、x2=インキュベーション、x3=四角、x4=丸、x5=丸、x6=インキュベーション。
項104/86.4:x1=四角、x2=星、x3=インキュベーション、x4=四角、x5=四角、x6=インキュベーション。
Claims (15)
- 複数の微小流体モジュールを含むシステムであって、
前記複数の微小流体モジュールが、少なくとも第1の微小流体モジュールを含み、
前記複数の微小流体モジュールは各々、他の微小流体モジュールと相互に連結して共働可能に構成された基本モジュール型を有することを特徴とし、
ここで前記基本モジュール型は、
(I)第1の表面を有する基材と、
(II)前記基材内に配置される流体制御構造と、
(III)少なくとも第1の端部及び第2の端部を含み、前記第1の端部が前記流体制御構造に連結されてなる流通パスと、
(IV)前記基材の第1の表面上に配置され、前記流通パスの前記第2の端部に連結されてなる流体コネクターと、
(V)前記基材の第1の表面に少なくとも一部が配置され、共働する他の微小流体モジュールとの間で流体の連通を許容する接合(coincident)インターフェース連結を確立する第1の連結要素と、
(VI)前記基材の第1の表面に少なくとも一部が配置され、共働する他の微小流体モジュールとの間で共線軸に沿った相対的な移動を許容する共線(collinear)インターフェース連結を確立する第2の連結要素とを有し、
ここで、共働する複数の微小流体モジュールを前記第1及び第2の連結要素で相互に連結し、共線軸に沿って相対的に移動させると、前記連結された共働する微小流体モジュール間で流体の移動が生じる
ことを特徴とする、微小流体モジュールシステム。 - 前記複数の微小流体モジュールが更に、第2の微小流体モジュールを含み、
前記第2の微小流体モジュールの基材が、前記第1の微小流体モジュール内に少なくとも部分的に収容され得る高さ、幅、及び深さを有する
ことを特徴とする、請求項1に記載の微小流体モジュールシステム。 - 前記第1の微小流体モジュールにおいて、
前記基材が、前記第1の表面に対向する第2の表面を更に有し、
前記流体制御構造が、駆動可能な液体分注装置を含み、
前記駆動可能な液体分注装置が、
(I)前記第1の表面に開口した内腔と、前記第2の表面と共通の壁面を共有する背面とを有するスロット、並びに、
(II)固体発泡体の特性を有する圧縮可能な基材
を有し、
前記圧縮可能な基材が、
(a)前記第1の表面と接合された分注面、
(b)前記分注面と対向し、前記スロットの背面と接合された駆動面、及び、
(c)直列に連結された1又は2以上のセルを含む直列化試薬クラスター
を有し、
前記1又は2以上のセルが、
(i)液体の包装に適した可撓性薄壁穿孔可能材料に個別に封入された包装液体試薬保存液を含む湿潤セル、及び、
(ii)長さを調節するスペーサー要素を含む乾燥セル
から選択される少なくとも1種のセルを含み、
前記直列化試薬クラスターが、前記駆動面と前記分注面との間に直列に配列され、前記駆動面及び前記分注面と連結されることにより、前記駆動面から前記直列化試薬クラスターの1又は2以上のセルを通じ前記分注面へと機械力を伝達することが可能な機械的結合を確立するように構成される
ことを特徴とする、請求項1に記載の微小流体モジュールシステム。 - 前記第1の微小流体モジュールにおいて、
前記流体制御構造が、内部容器を含み、
前記基材が更に、第2の表面と、1又は2以上の更なる表面とを含み、
前記流通パスが、前記内部容器を、前記第1の表面、前記第2の表面、及び前記の1又は2以上の更なる表面と連結してなる
ことを特徴とする、請求項1に記載の微小流体モジュールシステム。 - 前記第1の微小流体モジュールにおいて、
前記流体制御構造が、内部容器を含み、
前記基材が更に、前記第1の表面と対向する第2の表面を含み、
前記流通パスが、前記内部容器を、前記第1の表面及び第2の表面と連結してなる
ことを特徴とする、請求項1に記載の微小流体モジュールシステム。 - 前記第1の微小流体モジュールにおいて、
前記流体制御構造が、内部容器を含み、
前記基材が更に、前記第1の表面と隣接する第2の表面を含み、
前記流通パスが、前記内部容器を、前記第1の表面及び前記第2の表面と連結してなる
ことを特徴とする、請求項1に記載の微小流体モジュールシステム。 - 前記基本モジュール型の前記第1の連結要素が、箱型連結部のオペレータ及びレシーバから選択される少なくとも1種である
ことを特徴とする、請求項1に記載の微小流体モジュールシステム。 - 前記基本モジュール型の前記第1の連結要素が、クリップ・溝型連結部のクリップ及び溝から選択される少なくとも1種である
ことを特徴とする、請求項1に記載の微小流体モジュールシステム。 - 前記基本モジュール型の前記第2の連結要素が、プリズム型連結部のスライド及びスライドガイドから選択される少なくとも1種である
ことを特徴とする、請求項1に記載の微小流体モジュールシステム。 - 前記第1の微小流体モジュールにおいて、前記流体制御構造が、
(I)直列に連結された1又は2以上のセルを含む直列化試薬クラスター
を含み、
前記1又は2以上のセルが、
(a)液体の包装に適した可撓性薄壁穿孔可能材料に個別に封入された包装液体試薬保存液を含む湿潤セル、及び、
(b)長さを調節するスペーサー要素を含む乾燥セル
から選択される少なくとも1種のセルを含み、
前記直列化試薬クラスターが、前記駆動面と前記分注面との間に直列に配列され、前記駆動面及び前記分注面と連結されることにより、前記駆動面から前記直列化試薬クラスターの1又は2以上のセルを通じ前記分注面へと機械力を伝達することが可能な機械的結合を確立するように構成され、
前記複数の微小流体モジュールが更に、第2の微小流体モジュールを含み、前記第1及び第2の微小流体モジュールが、前記第1及び第2の連結要素を通じて相互に連結され、共働すると共に、
前記第1の微小流体モジュールを前記第2の微小流体モジュールに対して相対的に移動させると、前記第1の微小流体モジュールの前記直列化試薬クラスターの前記1又は2以上の湿潤セル及び前記1又は2以上の乾燥セルが、前記第2の微小流体モジュールに対して相対的に移動することにより、前記第1の微小流体モジュールの前記直列化試薬クラスターの前記1又は2以上の湿潤セル中の液体が、前記第2の微小流体モジュールへと連続的に移動するように構成される
ことを特徴とする、請求項1に記載の微小流体モジュールシステム。 - 前記流通パスが尖った先端を有する
ことを特徴とする、請求項10に記載の微小流体モジュールシステム。 - 前記直列化試薬クラスターが、少なくとも2つのセルを含み、前記少なくとも2つのセルのうち、少なくとも1つが湿潤セルであり、少なくとも1つが乾燥セルであり、
前記第1の微小流体モジュールを前記第2の微小流体モジュールに対して相対的に移動させると、前記少なくとも1つの湿潤セル内の液体が移動するまでに所定の時間間隔が生じるように、前記直列化試薬クラスター内における前記少なくとも1つの乾燥セルと前記少なくとも1つの湿潤セルとの相対位置が設定される
ことを特徴とする、請求項10に記載の微小流体モジュールシステム。 - 前記所定の時間間隔が、前記少なくとも1つの乾燥セルの長さの関数である
ことを特徴とする、請求項12に記載の微小流体モジュールシステム。 - 前記直列化試薬クラスターが、少なくとも2つのセルを含み、前記少なくとも2つのセルのうち、少なくとも1つが湿潤セルであり、少なくとも1つが乾燥セルであり、
前記第1の微小流体モジュールを前記第2の微小流体モジュールに対して相対的に移動させると、前記少なくとも1つの湿潤セル内の液体が移動するまでに所定の時間間隔が生じるように、前記直列化試薬クラスター内における前記少なくとも1つの乾燥セルと前記少なくとも1つの湿潤セルとの相対位置が設定される
ことを特徴とする、請求項3に記載の微小流体モジュールシステム。 - 前記所定の時間間隔が、前記少なくとも1つの乾燥セルの長さの関数である
ことを特徴とする、請求項14に記載の微小流体モジュールシステム。
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