JP6849044B2 - Membrane position adjustment device and blood purification system equipped with it - Google Patents

Description

The present invention relates to a membrane position adjusting device for adjusting the position of the diaphragm of a pressure measuring instrument, and a blood purification system including the same.

In blood purification therapy, a blood purification system is used. In the blood purification system, the blood flowing through the blood circuit is pumped to the blood purification device, purified by the blood purification device, and returned to the patient's blood vessels. A pressure measuring device is interposed in the blood circuit to measure the pressure of blood flowing through the blood circuit, and Patent Document 1, for example, is known as the pressure measuring device.

The hydraulic pressure measuring device of Patent Document 1 has a housing and a flexible film. The housing is interposed in a blood circuit, and the inside of the housing is divided into two separate chambers by a flexible membrane. The first compartment is filled with blood from the blood circuit and the second compartment is filled with air. In the hydraulic pressure measuring device, the flexible membrane fluctuates due to the change in the blood pressure in the first compartment, and the internal pressure in the second compartment changes accordingly. In this way, the pressure of blood is converted into air pressure, and the blood pressure is measured by detecting this air pressure with a pressure sensor. The hydraulic pressure measuring device of Patent Document 1 configured in this way has a function of adjusting the position of the flexible film.

Japanese Patent No. 3690846

In the hydraulic pressure measuring device of Patent Document 1, first, the air in the second compartment is evacuated by a pump, the flexible membrane is pressed against the wall of the housing, and then the pump is reversed to supply air to the second compartment. Press the flexible film against the wall of the housing. After that, the pump is rotated in the reverse direction for a predetermined time again to evacuate the air in the second compartment, and the flexible membrane is moved to the optimum position. The hydraulic pressure measuring device is adapted to adjust the position of the flexible film in this way. In the hydraulic pressure measuring device of Patent Document 1, it is necessary to deflate or supply air for a predetermined time in order to reliably press the flexible film against the wall of the housing regardless of the position of the flexible film, and a large pressure is applied to the housing. It is continuously applied to the flexible membrane even after being pressed against the wall. The flexible film may be damaged by the action of a large pressure on the flexible film. Further, since the flexible film is only sandwiched between the housings divided into upper and lower parts, the flexible film may come off from the housing when a large pressure is applied locally to the flexible film, and as a result, the second Blood leaks into the compartment. If the flexible membrane is damaged or comes off and leaks in this way, the hydraulic pressure cannot be measured accurately.

Therefore, an object of the present invention is to provide a membrane position adjusting device capable of suppressing the action of excessive pressure on the diaphragm.

The membrane position adjusting device of the present invention is interposed in either the upstream side or the downstream side of the blood pump in a blood circuit to which blood is sent by the blood pump, and has a housing having an internal space and a liquid chamber connected to the blood circuit. A pressure measuring instrument having a liquid chamber and a gas chamber filled with gas, and a diaphragm having a diaphragm whose position changes according to the internal pressure of the liquid chamber, and the liquid chamber. A gas amount adjuster that sucks or supplies a liquid, or sucks or supplies a gas to the gas chamber to adjust the amount of gas in the gas chamber, and a pressure detector that detects the pressure in the gas chamber. The position of the diaphragm is estimated based on the relationship between the amount of gas change changed by the gas amount regulator and the pressure detected by the pressure detector, and the fluid amount regulator is estimated according to the estimated position of the diaphragm. A membrane position adjusting device comprising a controller for driving the gas to adjust the position of the diaphragm to a predetermined normal position.

According to the present invention, the film position is estimated and the film position is adjusted to a predetermined position. Therefore, even if the film position is not adjusted to a predetermined position in advance, for example, at the time of manufacturing, the film position is adjusted by the controller. Can be adjusted. Further, since the membrane position is estimated and the gas amount adjuster is driven according to the membrane position, gas is excessively sucked or supplied to the gas chamber, or liquid is excessively sucked to the liquid chamber. Alternatively, it can be suppressed from being supplied. This makes it possible to prevent excessive pressure from being applied to the diaphragm.

According to the present invention, it is possible to suppress the action of excessive pressure on the diaphragm.

The above objectives, other objectives, features, and advantages of the present invention will be apparent from the following detailed description of preferred embodiments with reference to the accompanying drawings.

It is a circuit diagram which shows the blood purification system which includes the membrane position adjustment device which concerns on 1st Embodiment of this invention. It is sectional drawing which shows the pressure measuring instrument of the membrane position adjusting apparatus of FIG. It is sectional drawing which shows the blood chamber and the gas chamber of the pressure measuring instrument of FIG. It is a flowchart which shows the procedure of the film position adjustment processing. It is a flowchart which shows the procedure of a pressure detection work. It is a graph which shows the relative relationship between the injection amount of air and the pressure. It is a graph which shows the relative relationship between the suction amount of air, and pressure. It is a circuit diagram which shows the blood purification system which includes the membrane position adjusting apparatus which concerns on 2nd and 3rd Embodiment of this invention. It is sectional drawing which shows the drip chamber provided in the membrane position adjustment apparatus which concerns on 2nd Embodiment of FIG. It is sectional drawing which shows the drip chamber provided in the membrane position adjustment apparatus which concerns on 3rd Embodiment of FIG. It is a circuit diagram which shows the blood purification system which includes the membrane position adjusting apparatus which concerns on 4th and 5th Embodiment of this invention. It is a flowchart which shows the procedure of the film position adjustment processing by the film position adjustment apparatus of 4th Embodiment. It is a graph which shows the relative relationship between a blood supply flow rate and a detection pressure. It is a graph which shows the relative relationship between the suction flow rate of blood, and the detection pressure. It is a flowchart which shows the procedure of the film position adjustment processing by the film position adjustment apparatus of 5th Embodiment. It is a flowchart which shows the procedure of a pressure detection work. It is a graph which shows the relative relationship between a blood supply flow rate and a detection pressure. It is a graph which shows the relative relationship between the suction flow rate of air, and the detection pressure.

Hereinafter, the blood purification systems 2 and 2C including the membrane position adjusting devices 1, 1A to 1D and any of them according to the first to fifth embodiments according to the present invention will be described with reference to the above drawings. The concept of the direction used in the following description is used for convenience in the explanation, and does not limit the direction of the configuration of the invention to that direction. Further, the membrane position adjusting devices 1, 1A to 1D and the blood purification systems 2, 2C described below are only one embodiment of the present invention. Therefore, the present invention is not limited to the embodiment, and can be added, deleted, or changed without departing from the spirit of the invention.

<First Embodiment>
In the blood purification method for purifying blood, the blood purification system 2 shown in FIG. 1 is used. The blood purification system 2 takes in the blood flowing through the blood vessels of the patient into the blood purification system 2 to purify the blood, and returns the purified blood to the blood vessels of the patient. The blood purification system 2 includes a blood circuit 11, a blood pump 12, a blood purifier 13, two drip chambers 14 and 15, a priming liquid supply device 16, three valves 17 to 19, and a membrane position adjusting device. It has 1.

The blood circuit 11 is a flexible tube, and a liquid, mainly blood or a priming liquid, flows through a flow path in the tube. In addition, both ends of the blood circuit 11 can be connected to each of the patient's arteries and veins. Further, the blood circuit 11 is provided with a blood pump 12, and the blood pump 12 sends the liquid in the flow path of the blood circuit 11 from the upstream side to the downstream side. That is, the blood pump 12 can remove the blood from the artery into the flow path of the blood circuit 11 and return it to the vein. Further, the blood circuit 11 is provided with a blood purifier 13 on the downstream side of the blood pump 12.

The blood purifier 13 includes a blood purifier 21 and a dialysate supply / discharge device 22. The blood purifier 21 is interposed in the blood circuit 11 on the downstream side of the blood pump 12. The blood of the blood circuit 11 flows in the blood purifier 21, and the dialysate flows adjacent to the blood via the dialysis membrane. In the blood purifier 21, substance exchange and solute removal are performed between the blood and the dialysate via the dialysate, and the dialysate supply / drainage device 22 supplies the dialysate to the blood purifier 21 and substances. It is designed to drain the drainage after the effect and solute removal. In this way, the blood purifier 13 is adapted to purify blood using a dialysate.

Further, in the blood circuit 11, an upstream drip chamber 14 and a downstream drip chamber 15 are interposed on each of the upstream side and the downstream side of the blood purifier 21, and the two drip chambers 14 and 15 are the blood circuits 11. It is designed to take in the blood flowing through the chamber and remove gas such as air contained in the liquid from the blood. More specifically, each of the drip chambers 14 and 15 is connected to the air bleeding lines 24 and 25 in addition to the blood circuit 11, and the air in the drip chambers 14 and 15 is transferred from the air bleeding lines 24 and 25 to the atmosphere. It is released and removed.

Further, a priming liquid supply device 16 is connected to the upstream side of the blood pump 12 of the blood circuit 11. The priming liquid supply device 16 is, for example, a container containing a priming liquid, and the priming liquid of the priming liquid supply device 16 is supplied to the blood circuit 11 via the priming line 23 by driving the blood pump 12. It has become like. The priming line 23 is provided with an opening / closing valve 17 for priming.

The priming opening / closing valve 17 can input a priming line opening / closing signal, and opens / closes the priming line 23 according to an input state of the priming line opening / closing signal. In addition to the priming opening / closing valve 17, the blood circuit 11 is provided with upstream / downstream opening / closing valves 18 and 19 (opening / closing mechanism). The upstream opening / closing valve 18 is arranged upstream from the connection point between the priming line 23 and the blood circuit 11, and the downstream opening / closing valve 19 is arranged downstream of the downstream drip chamber 15 in the blood circuit 11. There is. Each of the upstream side and downstream side opening / closing valves 18 and 19 can input upstream side and downstream side opening / closing signals, and opens / closes the blood circuit 11 according to the input state of each signal. Further, each of the air bleeding opening / closing valves 26 and 27 is provided in the air bleeding lines 24 and 25, and the air bleeding lines 24 and 25 can be opened and closed by these valves. As described above, the blood circuit 11 and the air bleeding lines 24 and 25 are provided with an opening / closing mechanism 30 composed of five valves 17 to 19, 26 and 27 for opening and closing them.

The blood purification system 2 configured in this way has three pressure measuring instruments 31 for measuring the pressure of blood flowing through the blood circuit 11. The three pressure measuring instruments 31 are interposed in the blood circuit 11 and constitute the membrane position adjusting device 1 together with the adjusting device main body 32. The pressure measuring device 31 is a device for measuring the pressure of blood flowing through the blood circuit 11, and converts the pressure of the blood into a gas pressure, that is, an air pressure in the present embodiment. The three pressure measuring instruments 31 are interposed in the blood circuit 11 as shown in FIG. More specifically, each of the three pressure measuring instruments 31 has an upstream opening / closing valve 18 and a blood pump 12, a blood pump 12 and an upstream drip chamber 14, and an upstream drip chamber 15. It is arranged between the downstream opening / closing valve 19. In the following, the pressure measuring instrument 31 arranged on the most upstream side is the first pressure measuring instrument 31u, the pressure measuring instrument 31 arranged on the most downstream side is the second pressure measuring instrument 31d, and the remainder. The pressure measuring instrument 31 of the above may be referred to as a third pressure measuring instrument 31 m. These three pressure measuring instruments 31u, 31d, and 31m have the same configuration. Hereinafter, the configurations of the three pressure measuring instruments 31u, 31d, and 31m are referred to as pressure measuring instruments 31 and FIG. Will be explained in detail with reference to.

As shown in FIG. 2, the pressure measuring instrument 31 has a housing 41, a diaphragm 42, an air tube 43, and a female connector portion 44. The housing 41 is composed of a lower housing portion 41a and an upper housing portion 41b. The lower housing portion 41a has a substantially semi-elliptical shape that is long in a predetermined direction (in this embodiment, the blood flow direction in which blood flows in the pressure measuring instrument 31 and the left-right direction on the paper surface of FIG. 2). There is. In the lower housing portion 41a, an internal space having a substantially semi-elliptical shape that is long in a predetermined direction and projects downward is formed. Further, the lower housing portion 41a has an inflow hole 41c and an outflow hole 41d on both side surfaces in a predetermined direction, respectively. The inflow hole 41c and the outflow hole 41d extend in a predetermined direction, and the tube of the blood circuit 11 can be inserted and connected thereto. Further, the inflow hole 41c and the outflow hole 41d are connected to the internal space of the lower housing portion 41a, and the blood of the blood circuit 11 flows into the internal space of the lower housing portion 41a from the inflow hole 41c and the outflow hole 41d. It is supposed to flow out from. The internal space of the lower housing portion 41a opens upward, and the upper end portion of the lower housing portion 41a is covered with the upper housing portion 41b so as to close the opening.

The upper housing portion 41b is formed in a substantially dome shape, and is thinned so that a substantially semi-elliptical internal space that is long in a predetermined direction and protrudes upward is formed in the upper housing portion 41b. There is. Further, a connection port 41e is formed in the ceiling portion of the upper housing portion 41b so that air, which is a gas, can be supplied from the connection port 41e to the internal space of the upper housing portion 41b. The upper housing portion 41b having such a shape is opened downward, and a flange 41f extending over the entire circumference in the circumferential direction is formed at the opening end portion. The upper housing portion 41b is vertically overlapped with the lower housing portion 41a so that the flange 41f is placed on the upper end portion of the lower housing portion 41a, and the housing 41 is configured by overlapping and fixing the upper housing portion 41b. It has become. In the housing 41 configured in this way, an internal space 41 g having a substantially ellipsoidal shape elongated in a predetermined direction is formed, and a diaphragm 42 is arranged in the internal space 41 g.

The diaphragm 42 is a flexible film-like member, and is formed in a substantially semi-elliptical shape like the internal space of the upper housing portion 41b. A flange 42a is formed at the open end of the diaphragm 42 over the entire circumference in the circumferential direction, and the flange 42a is arranged between the upper end portion of the lower housing portion 41a and the flange 41f of the upper housing portion 41b. That is, the diaphragm 42 is sandwiched between the two housing portions 41a and 41b and fixed to the housing 41. In the initial state, the diaphragm 42 projects toward, for example, the upper housing portion 41b and is arranged along the inner wall of the upper housing portion 41b. The diaphragm 42 may be arranged along the inner wall of the lower housing portion 41a so as to project toward the lower housing portion 41a in the initial state as described later (see the alternate long and short dash line in FIG. 2). The diaphragm 42 arranged in this way divides the internal space 41 g of the housing 41 into two chambers, a blood chamber 45 and a gas chamber 46.

The blood chamber 45 is a chamber located on the bottom side of the housing portion 41a below the diaphragm 42, and is connected to the inflow hole 41c and the outflow hole 41d. Therefore, the blood flowing through the blood circuit 11 flows into the blood chamber 45 through the inflow hole 41c, and the blood in the blood chamber 45 flows out from the outflow hole 41d. On the other hand, the gas chamber 46 is a chamber located on the ceiling side of the housing portion 41b above the diaphragm 42. When the diaphragm 42 is arranged along the inner wall of the upper housing portion 41b so as to project toward the upper housing portion 41b as shown in FIG. 2, it is slightly between the inner peripheral surface of the upper housing portion 41b and the diaphragm 42. The gap is the gas chamber 46. The gas chamber 46 is connected to the connection port 41e, and air can be supplied from the connection port 41e. The air in the gas chamber 46 is pushed by the blood in the blood chamber 45 through the diaphragm 42, or pushes the blood in the blood chamber 45. By doing so, the flexible diaphragm 42 changes its position according to the internal pressure of the blood chamber 45 and the internal pressure of the gas chamber 46 so as to be separated from the inner peripheral surface of the upper housing portion 41b as shown in FIG. It has become.

Further, the vicinity of the opening end of the diaphragm 42 is thinner than the main body portion 42b, which is a residual portion, and a folded-back portion 42c is formed in the vicinity of the opening end of the diaphragm 42 over the entire circumference in the circumferential direction. By having such a shape, the diaphragm 42 is easily folded back at the folded-back portion 42c, and by folding back, the main body portion 42b can be projected toward the lower housing portion 41a. Further, by projecting, the main body portion 42b is arranged along the inner peripheral surface of the lower housing portion 41a. A blood passage 41h recessed below the inner peripheral surface is formed at the bottom of the lower housing portion 41a, and even if the main body portion 42b is arranged along the inner peripheral surface of the lower housing portion 41a. The flow from the inflow hole 41c to the outflow hole 41d (or the flow in the opposite direction) in the blood chamber 45 is not blocked. In this way, the diaphragm 42 can change the position of the main body portion 42b, that is, the position of the diaphragm 42 can be changed.

In this way, the diaphragm 42 can change the position of the main body portion 42b, that is, the position of the diaphragm 42 can be changed. Further, the air tube 43 is inserted into the connection port 41e of the housing 41. The air tube 43 has a passage through which air passes, and one end of the air tube 43 is inserted into a connection port 41e of the housing 41. A female connector portion 44 is provided at the other end of the air tube 43, and the air tube 43 is connected to the adjusting device main body 32 described later via the female connector portion 44. That is, air is supplied from the adjusting device main body 32 to the gas chamber 46 via the air tube 43 in each of the three pressure measuring instruments 31u, 31d, and 31m.

As shown in FIG. 1, the adjusting device main body 32 has three male connector portions 33. The male connector portion 33, which is the first and second connector portions, is composed of members having different colors. Further, the three male connector portions 33 are adapted to connect the female connector portions 44 of the pressure measuring instruments 31u, 31d, and 31 m associated with each of the three male connector portions 33. Each female connector portion 44 is composed of a member having the same color as the associated male connector portion 33, and it is suggested which male connector portion 33 should be connected to each female connector portion 44. There is. That is, each male connector portion 33 itself (more specifically, the housing of the male connector portion 33) serves as a teaching portion. The adjusting device main body 32 configured in this way detects the pressure in the gas chamber 46, estimates the position of the diaphragm 42 of the pressure measuring instrument 31, and adjusts the position of the diaphragm 42. Hereinafter, the configuration of the adjusting device main body 32 will be described in more detail.

As shown in FIG. 1, the adjusting device main body 32 has three gas amount adjusting machines 34, three pressure sensors 35, and a controller 36. Each of the three gas amount adjusters 34 is connected to each of the male connector portions 33 via separate adjustment lines 37. The gas amount adjuster 34 is connected to the gas chamber 46 of the pressure measuring instrument 31 via the adjusting line 37 and the air tube 43, and sucks the air in the gas chamber 46 or supplies the air to the gas chamber 46. The amount of air in the gas chamber 46 is adjusted accordingly. Specifically, each gas amount adjusting machine 34 has a adjusting pump 38 and a pump driving mechanism 39. The adjusting pump 38 is, for example, a cylinder type pump, and has a cylinder 38a and a piston 38b. The adjusting pump 38 is not limited to the cylinder type pump, and the configuration is not limited as long as the pump can adjust the flow rate to be supplied. The cylinder 38a is connected to the adjusting line 37, and the piston 38b is inserted into the cylinder 38a so as to be able to advance and retreat. The piston 38b is provided with a pump drive mechanism 39. The pump drive mechanism 39 is composed of, for example, a ball screw mechanism, and moves the piston 38b forward and backward by a distance corresponding to the advance / retreat signal input to the pump drive mechanism 39.

The gas amount adjuster 34 configured in this way advances and retreats the piston 38b in response to the advance / retreat signal. When the piston 38b advances, an amount of gas (volume in the present embodiment) corresponding to the advancing distance is supplied from the cylinder 38a to the gas chamber 46 via the adjusting line 37. On the other hand, when the piston 38b retracts, the amount of gas (volume in the present embodiment) corresponding to the retracted distance is sucked from the gas chamber 46 into the cylinder 38a via the adjusting line 37. Further, each adjustment line 37 has a detection line 40 branched from the middle thereof, and is connected to the pressure sensor 35 via the detection line 40. The pressure sensor 35 outputs a pressure signal according to the internal pressure of the gas chamber 46 via the adjustment line 37, and the pressure sensor 35 outputs a pressure signal to the controller 36. ..

The controller 36 detects the internal pressure of each gas chamber 46 based on the pressure signal from the pressure sensor 35, that is, detects the pressure of blood in the blood chamber 45 (that is, the internal pressure of the blood chamber 45). .. Further, the controller 36 is individually electrically connected to the three pump drive mechanisms 39, and is also electrically connected to the five valves 17 to 19, 26, 27 and the blood pump 12. The controller 36 outputs a signal corresponding to each configuration electrically connected in this way, and controls the movement of each configuration. Further, the controller 36 is connected to the alarm 50 included in the adjusting device main body 32. The alarm device 50 is composed of, for example, a red light, an LED display, or the like, and notifies the practitioner and the patient of a predetermined situation. In the present embodiment, the alarm device 50 notifies an alarm that there is a connection failure of the female connector portion 44 or an air leak of the air tube 43 based on a command from the controller 36.

In the blood purification system 2 configured in this way, one end of the blood circuit 11 (that is, the end on the upstream opening / closing valve 18 side and the end on the arterial side) is connected to the patient's artery, and the blood circuit The other end of 11 (that is, the end on the downstream opening / closing valve 19 side and the end on the vein side) is connected to the patient's vein. In this state, the controller 36 drives the blood pump 12 so that blood flows from one end to the other end of the blood circuit 11. Since the first pressure measuring instrument 31u is located upstream of the blood pump 12, the blood in the blood chamber 45 of the first pressure measuring instrument 31u is sucked by the blood pump 12 by driving the blood pump 12. The blood chamber 45 becomes negative pressure. On the other hand, in the second pressure measuring instrument 31d and the third pressure measuring instrument 31m, since they are located on the downstream side of the blood pump 12, the pressure measuring instruments 31d and 31m are driven by the blood pump 12. Blood is pumped into the blood chamber 45 of the blood chamber 45, and the blood chamber 45 becomes a positive pressure. That is, in the first pressure measuring instrument 31u, the diaphragm 42 is pulled toward the blood chamber 45 to change its position, and in the second pressure measuring instrument 31d and the third pressure measuring instrument 31m, the diaphragm 42 is the gas chamber 46. It is pushed to the side to change its position. By changing the position of the diaphragm 42 in this way, the air in the gas chamber 46 expands or compresses, and as a result, the pressure of the air in the gas chamber 46 changes. That is, the internal pressure of the blood chamber 45 is converted into air pressure by the diaphragm 42, and the membrane position adjusting device 1 measures the internal pressure of the blood chamber 45 by detecting this air pressure using the pressure sensor 35.

Further, the diaphragm 42 is designed to convert the internal pressure of the blood chamber 45 into air pressure, but the larger the absolute value of the negative pressure of the blood chamber 45, the greater the pull toward the lower housing portion 41a. On the contrary, the diaphragm 42 is pushed out more toward the upper housing portion 41b as the absolute value of the positive pressure of the blood chamber 45 increases. Therefore, when the first pressure measuring instrument 31u detects the negative pressure, the diaphragm 42 projects toward the upper housing portion 41b in the initial state and is arranged along the inner wall of the upper housing portion 41b, that is, the diaphragm. It is preferable to arrange the main body portion 42b of 42 at the upper limit position (limit position). By arranging in this way, the negative pressure can be measured over a wide range. Therefore, in the first pressure measuring instrument 31u, it is preferable that this membrane position is the normal position of the diaphragm 42. On the other hand, when the second pressure measuring instrument 31d and the third pressure measuring instrument 31m detect positive pressure, the diaphragm 42 projects toward the lower housing portion 41a in the initial state and follows the inner wall of the lower housing portion 41a. That is, it is preferable to arrange the main body portion 42b of the diaphragm 42 at the lower limit position (limit position). By arranging in this way, the positive pressure can be measured over a wide range. Therefore, in the second pressure measuring instrument 31d and the third pressure measuring instrument 31m, it is preferable that this membrane position is the normal position of the diaphragm 42.

As described above, the three pressure measuring instruments 31u, 31d, 31m are used by adjusting the position of the diaphragm 42 according to the arranged position, but the three pressure measuring instruments 31u, 31u, The 31d and 31m have the same configuration and are generally manufactured by the same method. That is, the diaphragm 42 before use projects to either the lower housing portion 41a or the upper housing portion 41b. Therefore, when the diaphragm 42 is used, the position of the diaphragm 42 is estimated, and when the diaphragm 42 is not in the normal position, for example, when the diaphragm 42 is manufactured so as to project toward the upper housing portion 41b as shown in FIG. 2, the second pressure It is necessary to adjust the position of the diaphragm 42 on the measuring instrument 31d and the third pressure measuring instrument 31m.

Further, in the blood purification system 2, priming is performed to clean the inside of the blood circuit 11 and the blood purification machine 13 and to remove the air in them before performing the blood purification therapy on the patient. At this time, the blood flowing through the blood circuit 11 may change the position of the diaphragm 42 of each pressure measuring instrument 31u, 31d, 31m. Therefore, it is necessary to estimate the position of the diaphragm 42 after priming and adjust the diaphragm 42 to the normal position when the diaphragm 42 is not in the normal position.

As described above, in the blood purification system 2, the position of the diaphragm 42 of each pressure measuring instrument 31u, 31d, 31m may not be in the normal position due to various factors. Therefore, the controller 36 executes the membrane position adjusting process, and the diaphragm 42 is based on the relationship between the amount of gas (volume in the present embodiment) sucked or supplied by the gas amount adjuster 34 and the internal pressure of the gas chamber 46. The position of is estimated. Further, in the membrane position adjusting process, the controller 36 drives the gas amount adjuster 34 according to the estimated position of the diaphragm 42 to adjust the diaphragm 42 to a predetermined position. Hereinafter, the film position adjusting process will be described with reference to FIG.

The membrane position adjustment process is started when, for example, both ends of the blood circuit 11 are connected to form a loop or the arterial end of the blood circuit 11 is closed, and then a priming command is input by an input device (not shown). Move to S1. In step S1, which is the priming step, priming is performed. That is, the controller 36 outputs a first open / close signal to the priming open / close valve 17 to open the priming line 23 and drive the blood pump 12. As a result, the priming liquid is sucked from the priming liquid supply device 16 into the blood pump 12 via the arterial side portion of the blood circuit 11, and is further supplied from the blood pump 12 to the venous side portion of the blood circuit 11. This causes the priming solution to circulate in the loop. When the three valves 17 to 19 are open, the blood circuit 11 is open to the atmosphere via the air bleeding lines 24 and 25, so that the priming liquid circulates in the blood circuit 11 and the blood purifier 13. The air is removed and the blood circuit 11 and the blood purifier 13 are filled with the priming solution. When priming is performed, the process proceeds to step S2.

In step S2, which is a priming end determination step, it is determined whether or not priming has been completed. That is, the controller 36 flows a specified amount of liquid and determines the presence or absence of bubbles remaining in the blood circuit 11 by a bubble sensor (not shown). If it is determined that there are air bubbles, the process returns to step S1 and priming is continued. On the other hand, when it is determined that there are no bubbles, the controller 36 stops the blood pump 12 and ends the priming, assuming that the blood circuit 11 and the blood purifier 13 are sufficiently filled with the priming liquid. When the priming is completed, the process proceeds to step S3.

In step S3, which is the clamping step, the priming line 23, the blood circuit 11, and the air bleeding line 24, 25 are closed by the five valves 17 to 19, 26, 27. That is, the controller 36 inputs the first open / close signal to the priming open / close valve 17 to close the priming line 23, and also inputs the second and third open / close signals to the upstream and downstream open / close valves 18 and 19. Closes the vicinity of both ends of the blood circuit 11. Further, the fourth opening / closing signal and the fifth opening / closing signal are input to the air bleeding opening / closing valves 26 and 27 to close the air bleeding lines 24 and 25. As a result, the blood circuit 11 that has been open to the atmosphere is sealed. When the blood circuit 11 is sealed, the process proceeds to step S4. In step S4, which is the number reset step, the pressure detection number n is set to zero. When the pressure detection number n becomes zero, the process proceeds to step S5.

In step S5, which is the pressure detection step, the pressure detection process is executed. The pressure detection process is a process of changing the volume of the gas chamber 46 of the three pressure measuring instruments 31u, 31d, and 31 m by a predetermined amount and detecting the pressure after the change. In the pressure detection process, the detection method is different between the first pressure measuring instrument 31u for detecting the negative pressure and the second pressure measuring instrument 31d and the third pressure measuring instrument 31m for detecting the positive pressure. Specifically, the first pressure measuring instrument 31u detects the pressure after sucking air from the gas chamber 46, and the second pressure measuring instrument 31d and the third pressure measuring instrument 31m have their gas chambers. The pressure is detected after supplying air to 46. Hereinafter, the pressure detection process will be described with reference to FIG.

When the pressure detection process is executed, the process proceeds to step S21. In step S21, which is an air suction / supply step, the gas amount regulator 34 sucks or supplies a predetermined amount of air, that is, a predetermined volume of air. That is, in step S21, first, the controller 36 drives the pump drive mechanism 39 to suck air from the adjusting pump 38 from the gas chamber 46 of the first pressure measuring instrument 31u. At this time, the controller 36 controls the movement of the pump drive mechanism 39 to retract the piston 38b by a predetermined distance. As a result, a predetermined volume of air corresponding to the predetermined distance is sucked from the gas chamber 46 into the adjusting pump 38. On the other hand, in the second pressure measuring instrument 31d and the third pressure measuring instrument 31m, the controller 36 drives the pump drive mechanism 39 to supply air to the gas chamber 46 by the adjusting pump 38. At this time, the controller 36 controls the movement of the pump drive mechanism 39 to supply a predetermined volume of air according to the distance from the adjusting pump 38 to the gas chamber 46. When the air supply and suction are completed for the three pressure measuring instruments 31u, 31d, and 31m, the process proceeds to step S22. In step S22, which is a pressure detection step, the controller 36 detects the internal pressure of the gas chambers 46 of the three pressure measuring instruments 31u, 31d, and 31m based on the signal from the pressure sensor 35. When the internal pressure of the gas chamber 46 is detected, the detected internal pressure (hereinafter, also referred to as “detected pressure”) is stored in the controller 36 in association with the predetermined volume for each of the three pressure measuring instruments 31u, 31d, 31m. To. When stored in the controller 36, the pressure detection process ends and the process proceeds to step S6.

In step S6, which is the detection number counting step, 1 is added to the pressure detection number n. When 1 is added to the pressure detection number n, the process proceeds to step S7. In step S7, which is the specified number of times determination step, the controller 36 determines whether the pressure detection number n is equal to or greater than the specified number of times a. When it is determined that the pressure detection number n is equal to or less than the specified number a, the process returns to step S5, and pressure detection is performed until the pressure detection number n exceeds the specified number a. In the pressure detection process, the volume to be sucked or supplied is increased by a specified amount each time the pressure detection process is performed. That is, the controller 36 moves the piston 38b to the initial position when n = 0, and moves the piston 38b by a predetermined distance L each time the pressure detection number n increases. As a result, when the number of pressure detections is n, the piston 38b moves by n × L from the initial position, and the corresponding volume of air is sucked from the gas chamber 46 or supplied to the gas chamber 46. When the pressure detection process is repeated and the pressure detection number n exceeds the specified number a, the process proceeds to step S8.

In step S8, which is a correlation determination step, it is determined whether or not the relationship between the volume change amount and the pressure of each pressure measuring instrument 31u, 31d, 31m has a correlation with a preset predetermined relationship. This is because the amount of air sucked or supplied is very small and the blood circuit 11 is sealed, so that the position of the diaphragm 42 hardly changes in the first pressure measuring instrument 31u. Therefore, by sucking or supplying air to the gas chamber 46, the air in the closed space 51 composed of the gas chamber 46, the air tube 43, the adjusting line 37 and the cylinder 38a expands or compresses according to Boyle's law. Will be done. That is, the volume of the gas chamber 46 in the initial state before suction or supply is the volume V ₁ , the total volume of the air tube 43, the adjustment line 37 and the cylinder 38a in the initial state is the initial volume V ₂ , and the suction of the adjustment pump 38. or volume changes the volume of the supplied air volume V _3, the atmospheric pressure atmospheric pressure P _0, and when the pressure detected as the detection pressure P _x, the detection pressure P _x to be detected is represented by the following formula (1) Is done.

In the film position adjusting device 1 in which the initial position of the cylinder 38a is predetermined, the volume V ₂ is a predetermined value. Therefore, the relationship between the volume change and the pressure by the adjusting pump 38 (that is, the relationship between the volume change amount V ₃ and the detected pressure P _{x ) is the volume V 1} of the gas chamber 46 in the initial state, that is, the initial stage of the diaphragm 42. It depends on the position. The graphs of FIGS. 6 and 7 show the relationship between _{the volume change amount V 3} and the detected pressure P _x. The vertical axis of FIG. 6 and 7 show the detection pressure P _x, the horizontal axis represents the volume change V _{3. Further, the graph of FIG. 6 shows the relationship between the volume change amount V 3} and the detected pressure P _x when air is sucked from the gas chamber 46 with respect to the negative pressure measurement type pressure measuring instrument 31, and the graph of FIG. 7 shows the relationship. The relationship between _{the volume change amount V 3} and the detected pressure P _x when air is supplied to the gas chamber 46 with respect to the positive pressure measurement type pressure measuring instrument 31 is shown.

For example, the relationship between the volume change V ₃ shown by a solid line a1 and ◇ point and the detected pressure P _x in Figure 6, along the inner wall of the upper housing portion 41b diaphragm 42 is protruded to the upper housing portion 41b side in the initial state The above relationship is shown when the volume of the gas chamber 46 is approximately 0 ml (when the diaphragm 42 is arranged at a normal position in the negative pressure measurement type pressure measuring instrument 31). The relationships shown by the solid lines a1 and ◇ in FIG. 6 are relationships calculated by, for example, experiments, etc., and are defined relationships in the first pressure measuring instrument 31u. The same applies to each relationship described below. Relationship between the volume change V ₃ shown by a solid line a2 and △ point and the detected pressure P _x in Figure 6, the diaphragm 42 is disposed slightly away from the inner wall of the upper housing portion 41b in the initial state, the volume of the gas chamber 46 This is the case when it is approximately α ml (0 <α). Relationship between the volume change V ₃ shown by a solid line a3 and □ point of Figure 6 and the detected pressure P _x is spaced apart slightly diaphragm 42 in the initial state from the inner wall of the upper housing portion 41b as compared with the case of the solid line a1 Moreover, it is arranged closer to the inner wall of the upper housing portion 41b as compared with the case of the solid line a2. That is, it is the relationship between the _{volume change amount V 3} and the detection pressure P _x when the volume of the gas chamber 46 in the initial state is approximately β (0 <β <α) ml.

_{On the other hand, the relationship between the volume change amount V 3} shown by the solid line b1 and the ◇ point in FIG. 7 and the detected pressure P _x is such that the diaphragm 42 protrudes toward the lower housing portion 41a in the initial state and the inner wall of the lower housing portion 41a. The above relationship is shown when the volume of the gas chamber 46 is the maximum when the gas chamber 46 is arranged along the above (when the diaphragm 42 is arranged at a normal position in the positive pressure measurement type pressure measuring instrument 31). The relationship shown by the solid line b1 and the ◇ point in FIG. 7 is a defined relationship between the second pressure measuring instrument 31d and the third pressure measuring instrument 31m. _{Further, the relationship between the volume change amount V 3} shown by the solid line b2 and the point Δ in FIG. 7 and the detected pressure P _x is such that the diaphragm 42 is arranged slightly away from the inner wall of the lower housing portion 41a in the initial state, and is in the initial state. This is the case where the gas chamber 46 is reduced by approximately γ ml from the case of the solid line b1. Relationship between the volume change V ₃ shown by a solid line b3 and □ point of Figure 7 and the detection pressure P _x is spaced apart slightly diaphragm 42 from the inner wall of the lower housing portion 41a than in the case of the solid line b1 in the initial state It is arranged closer to the inner wall of the lower housing portion 41a as compared with the case of the solid line b2. That is, the gas chamber 46 in the initial state is reduced by approximately ε (0 <ε <γ) ml from the case of the solid line b1.

As can be seen from the graphs of FIGS. 6 and 7, when the volume of the gas chamber 46 in the initial state, that is, the initial position of the diaphragm 42 is different, the relationship between the _{volume change amount V 3} and the detected pressure P _{x is different.} In step S8, the relationship between the volume change amount V ₃ and the detection pressure P _x is defined _{in consideration of the relationship between the volume change amount V 3} and the detection pressure P _x that change according to the initial position of the diaphragm 42. The position of the diaphragm 42 is estimated by determining whether or not the diaphragm has a correlation with the relationship. Hereinafter, the determination of the controller 36 regarding the presence or absence of correlation will be described in detail.

The controller 36 stores a plurality of specified pressures associated with different volume changes for negative pressure measurement. The specified pressure is a pressure value in a specified relationship as shown in the graph shown in FIG. 6, and is a pressure value when the volume is changed by a specified amount. That is, it is a point ◇ on the solid line a1 in FIG. Further, the controller 36 stores a plurality of specified pressures associated with different volume change amounts for positive pressure measurement. The specified pressure is a pressure value in a specified relationship as shown in the graph shown in FIG. 6, and is a pressure value when the volume is changed by a specified amount. That is, it is a ◇ point on the solid line b1 in FIG. Therefore, in the present embodiment, the controller 36 stores six specified pressures in advance.

In step S8, the controller 36 compares the specified pressure and the detected pressure at the same volume change amount for each of the pressure measuring instruments 31u, 31d, and 31 m, and the specified pressure and the detected pressure are the same for all the volume change amounts. Determine if it is a value. For example, in the case of the first pressure measuring instrument 31u, the specified pressure for negative pressure measurement and the detected pressure are compared, and in the case of the second pressure measuring instrument 31d and the third pressure measuring instrument 31m, for positive pressure measurement. Compare the specified pressure with the detected pressure. Further, whether or not the specified pressure and the detected pressure are the same does not necessarily mean that they are exactly the same, and the detected pressure is within a predetermined range based on the specified pressure. In some cases, it may be determined that they are the same. If they are the same, the controller 36 _{determines that the relationship between the volume change amount V 3} based on the detected pressure and the detected pressure P _x has a correlation with the specified relationship. If it is determined that there is a correlation for all the pressure measuring instruments 31u, 31d, 31m, it is presumed that the diaphragm 42 is placed in the normal position. In the present embodiment, in the case of the first pressure measuring instrument 31u, the diaphragm 42 is arranged along the inner wall of the upper housing portion 41b, and in the case of the second pressure measuring instrument 31d and the third pressure measuring instrument 31m, the lower side. It is presumed that the diaphragm 42 is arranged along the inner wall of the housing portion 41a, respectively. Then, since the diaphragm 42 of each pressure measuring instrument 31u, 31d, 31m is arranged at the normal position, step S8 is completed and the membrane position adjusting process is also completed. On the other hand, if it is determined that there is no correlation with respect to at least one of the pressure measuring instruments 31u, 31d and 31m, it is estimated that the diaphragm 42 of the uncorrelated pressure measuring instrument 31 is not arranged at the normal position. For example, in the case of the first pressure measuring instrument 31u, the diaphragm 42 is arranged on the lower housing portion 41a side (that is, the blood chamber 45 side) from the normal position, and the second pressure measuring instrument 31d and the third pressure measuring instrument 31u are used. In the case of the instrument 31m, it is presumed that the diaphragm 42 is arranged on the housing portion 41b side (that is, the gas chamber 46 side) above the normal position. Then, the process proceeds to step S9 in order to adjust the diaphragm 42 of the uncorrelated pressure measuring instrument 31 to the normal position.

In step S9, which is the adjustment number determination step, the controller 36 determines whether the adjustment number i of the position of the diaphragm 42 exceeds the specified number b. If the controller 36 determines that the number of adjustments i does not exceed the specified number of times b, the process proceeds to step S10. In step S10, which is the adjustment number counting step, 1 is added to the adjustment number i. When 1 is added to the adjustment number i, the process proceeds to step S11. In step S11, which is a blood circuit opening step, the priming line 23, the blood circuit 11, and the air bleeding lines 24 and 25 closed in the clamping step are opened to open the blood circuit 11 to the atmosphere. That is, the controller 36 stops the open / close signals input to the five valves 17 to 19, 26, and 27 to open the priming line 23, the blood circuit 11, and the air bleeding lines 24 and 25. When it is opened, the process proceeds to step S12.

In step S12, which is a membrane position adjusting step, the amount of air in the gas chambers 46 of the pressure measuring instruments 31u, 31d, and 31 m for which the membrane position of the diaphragm 42 should be adjusted is adjusted. For example, when adjusting the position of the diaphragm 42 with respect to the first pressure measuring instrument 31u, the controller 36 sucks air from the gas chamber 46 of the first pressure measuring instrument 31u by the adjusting pump 38. When sucked, the priming line 23 is open to the atmosphere, so that the diaphragm 42 is attracted to the upper housing portion 41b side. The controller 36 stops driving the pump drive mechanism 39 when the detected pressure becomes atmospheric pressure or less. As a result, the diaphragm 42 of the first pressure measuring instrument 31u is adjusted to the normal position. When adjusting the position of the diaphragm 42 with respect to the second pressure measuring instrument 31d and the third pressure measuring instrument 31m, the controller 36 uses the adjusting pump 38 to adjust the second pressure measuring instrument 31d and the third pressure measuring instrument 31m. Air is supplied to the gas chamber 46 of the above. When supplied, the blood circuit 11 is open to the atmosphere, so that the diaphragm 42 is pressed against the lower housing portion 41a. Then, the controller 36 stops driving the pump drive mechanism 39 when the detected pressure becomes atmospheric pressure or higher. As a result, the diaphragm 42 of the second pressure measuring instrument 31d and the third pressure measuring instrument 31m is adjusted to the normal position. In step S13, only the position of the diaphragm 42 presumed not to be arranged at the normal position is adjusted, but the position of the diaphragm 42 may be adjusted for all the pressure measuring instruments 31u, 31d, 31m. .. When the position of the diaphragm 42 is adjusted in step S12, the process returns to step S3.

In step S3, the priming line 23, the blood circuit 11, and the air bleeding lines 24, 25 are closed again by the five valves 17-19, 26, 27. Then, the pressure is detected again in steps S4 to S7, and the presence or absence of correlation is determined in step S8. In step S8, it is determined again that there is no correlation, and in step S9, it is determined whether the adjustment number i exceeds the specified number b. Here, if it is determined that the number of adjustments i exceeds the specified number of times b, the process proceeds to step S13. In step S13, which is an alarm step, the alarm 50 notifies the connection failure or air leakage. That is, if the detection pressure does not change and the position of the diaphragm 42 is repeatedly adjusted, the detection pressure does not become the same as the specified pressure and the number of adjustments i exceeds the specified number during suction or supply, the controller 36 is connected. Judge that there is a possibility of failure or air leakage. Then, the controller 36 sends a command to the alarm 50 to notify an alarm that there is a possibility of a connection failure of the female connector portion 44 or an air leak of the air tube 43. Upon notification, the controller 36 stops the movement of each configuration of the adjusting device main body 32. When the movement is stopped, the film position adjustment process is completed. After the membrane position adjustment process is completed, problems such as fixing the connection failure and eliminating the leakage of the air tube 43 can be solved, and the restart of the film position adjustment process can be input from an input device (not shown). The film position adjustment process is restarted.

The membrane position adjusting device 1 of the present embodiment executes the membrane position adjusting process, estimates the position of the diaphragm 42, and adjusts the diaphragm 42 to the normal position when the diaphragm 42 is not arranged at the normal position. it can. The three pressure measuring instruments 31u, 31d, and 31m are used by arranging the diaphragm 42 protruding from either the lower housing portion 41a or the upper housing portion 41b according to the state of blood pressure to be measured. It is preferable to do so. Even in the pressure measuring instrument 31 in which the diaphragm 42 is arranged in this way, the position of the diaphragm 42 can be adjusted based on the estimated position by estimating the position of the diaphragm 42. As a result, it is not necessary to adjust the film position at the time of manufacturing, and the adjustment of the film position at the time of manufacturing can be omitted. Therefore, the film position adjustment work that is artificially performed can be omitted, and the manufacturing cost associated with the artificial work can be reduced. On the other hand, when the diaphragm 42 is arranged at the normal position, the adjustment work of the diaphragm 42 is not performed, so that the adjustment time can be shortened.

Further, since the membrane position adjusting device 1 estimates the position of the diaphragm 42 and drives the gas amount adjusting device 34 according to the position to suck or supply air, the air is excessively sucked or supplied to the gas chamber 46. It can be suppressed. As a result, it is possible to prevent the diaphragm 42 from being subjected to excessive pressure and changing the characteristics of the diaphragm 42, and it is possible to prevent the measurement result after the position adjustment of the diaphragm 42 from being varied for each membrane position adjusting device 1. be able to.

Further, in the membrane position adjusting device 1, when the diaphragm 42 of the first pressure measuring instrument 31u is arranged on the blood chamber 45 side from the normal position, the position of the diaphragm 42 is adjusted so as to be arranged on the gas chamber 46 side. Will be done. As described above, in the first pressure measuring instrument 31u, the blood in the blood chamber 45 is sucked by the blood pump 12, and the diaphragm 42 of the first pressure measuring instrument 31u measures the blood pressure. At that time, it is pulled toward the blood chamber 45 side. Therefore, by sucking the air in the gas chamber 46 and adjusting the position of the diaphragm 42 toward the gas chamber 46, the movable range of the diaphragm 42 at the time of measurement can be increased, and the first pressure measuring instrument 31u can be used. The range of measurable negative pressure can be increased. Further, when adjusting the position of the diaphragm 42 of the first pressure measuring instrument 31u, the controller 36 stops the suction of air from the gas chamber 46 when the detected pressure becomes a specified pressure, for example, atmospheric pressure or higher. ing. By doing so, the diaphragm 42 can be arranged so as to protrude most toward the gas chamber 46, that is, along the inner wall of the upper housing portion 41b. As a result, the range of the measurable negative pressure of the first pressure measuring instrument 31u can be increased, and the size of the housing 41 of the first pressure measuring instrument 31u can be reduced.

Similarly, in the membrane position adjusting device 1, if the diaphragm 42 of the second pressure measuring instrument 31d and the third pressure measuring instrument 31 m is arranged on the gas chamber 46 side from the normal position, it is arranged on the blood chamber 45 side. The position of the diaphragm 42 is adjusted so as to be. As described above, in the second pressure measuring instrument 31d and the third pressure measuring instrument 31m, blood is supplied to the blood chamber 45 by the blood pump 12, and the second pressure measuring instrument 31d and the third pressure measuring instrument 31d and the third. The diaphragm 42 of the pressure measuring instrument 31 m is pushed toward the gas chamber 46 when measuring the pressure of blood. Therefore, by adjusting the position of the diaphragm 42 to the blood chamber 45 side, the movable range of the diaphragm 42 at the time of measurement can be increased, and the measurement is performed by the second pressure measuring instrument 31d and the third pressure measuring instrument 31m. The range of possible positive pressure can be increased. Further, when adjusting the positions of the diaphragm 42 of the second pressure measuring instrument 31d and the third pressure measuring instrument 31 m, the controller 36 stops the supply of air to the gas chamber 46 when the detected pressure becomes atmospheric pressure or higher. It has become like. By doing so, the diaphragm 42 can be arranged so as to protrude most toward the blood chamber 45, that is, along the inner wall of the lower housing portion 41a. As a result, the range of measurable negative pressure of the second pressure measuring instrument 31d and the third pressure measuring instrument 31m can be widened, and the range of the second pressure measuring instrument 31d and the third pressure measuring instrument 31m can be increased. The size of the housing 41 can be reduced.

Further, in the membrane position adjusting device 1, the pressure detecting method and the position of the diaphragm 42 to be adjusted differ depending on whether the pressure measuring instrument 31 is arranged on the upstream side or the downstream side of the blood pump 12. That is, the processing to be executed by the adjusting pump 38 differs between the first pressure measuring instrument 31u and the second and third pressure measuring instruments 31d and 31m (that is, whether the suction processing should be executed or the supply processing is executed). Each pressure measuring instrument 31u, 31d, 31m must be connected to the corresponding gas gauge 34. The female connector portions 44 of the three pressure measuring instruments 31u, 31d, and 31 m are composed of members having different colors from each other, and are composed of members having the same color as the male connector portion 33 to be connected. Therefore, it is possible to encourage the female connector portion 44 to be connected to the male connector portion 33 to be connected, and the diaphragm 42 of each pressure measuring instrument 31u, 31d, 31m can be adjusted to a normal position.

Further, in the film position adjusting device 1, the gas amount adjusting device 34 is connected to the connection port 41e of the gas chamber 46 via the adjusting line 37 and the air tube 43, and the pressure sensor 35 is based on the pressure of the adjusting line 37. Is designed to output a signal. Therefore, it is not necessary to separately connect the detection line for the pressure sensor 35 to the lower housing portion 41a, and it is possible to prevent the detection line from being accidentally connected to another port.

Further, in the blood purification system 2 of the present embodiment, the position of the diaphragm 42 is detected and adjusted after the priming is performed. Therefore, even if the position of the diaphragm 42 of each pressure measuring instrument 31u, 31d, 31m fluctuates when the priming liquid is circulated, the position of the diaphragm 42 can be adjusted to the normal position before performing blood purification. .. Thereby, the pressure of blood flowing in the blood circuit 11 at the time of blood purification can be measured in a wide range.

<Second Embodiment>
The membrane position adjusting device 1A of the second embodiment has a structure similar to that of the membrane position adjusting device 1 of the first embodiment, and is provided in the blood purification system 2. In the following, the configuration of the film position adjusting device 1A of the second embodiment will be mainly described as being different from the film position adjusting device 1 of the first embodiment, and the same configuration will be illustrated and described with the same reference numerals. Is omitted. The same applies to the third to fifth embodiments.

As shown in FIG. 8, the film position adjusting device 1A has drip chambers 14A and 15A. The drip chambers 14A and 15A are interposed in each of the upstream side and the downstream side of the blood purifier 21 in the blood circuit 11. The drip chambers 14A and 15A have the same functions as the drip chambers 14 and 15, and also serve as a pressure measuring instrument 31. That is, the drip chambers 14A and 15A are instruments used for measuring the pressure of blood flowing through the blood circuit 11. Further, the drip chambers 14A and 15A have the same configuration. Hereinafter, the configuration of the drip chamber 14A will be specifically described with reference to FIG. 9, and the configuration of the drip chamber 15A will be omitted.

As shown in FIG. 9, the drip chamber 14A has a housing 61, a diaphragm 62, an air tube 43, and a female connector portion 44. The housing 61 is composed of a lower housing portion 61a and an upper housing portion 61b. The lower housing portion 61a, which is the first housing, is formed in a substantially cylindrical shape, and the lower portion is tapered toward the tip end. The lower opening of the lower housing portion 61a forms an outflow hole 61d, and the downstream portion 11a of the blood circuit 11 is inserted into the outflow hole 61d. Further, an inflow hole 61c is formed on the outer peripheral surface of the lower housing portion 61a, and an upstream portion 11b of the blood circuit 11 is inserted into the inflow hole 61c. Further, the upper opening end portion of the lower housing portion 61a is covered with the upper housing portion 61b so as to close the upper opening.

The upper housing portion 61b, which is the second housing, is formed in a substantially cylindrical shape, and a connection port 61e is formed in the ceiling portion of the upper housing portion 61b. The connection port 61e can supply air, which is a gas, into the upper housing portion 61b from the connection port 61e. The upper housing portion 61b having such a shape is attached to the lower housing portion 61a by exteriorizing the open end portion of the upper housing portion 61b to the upper opening end portion of the lower housing portion 61a. As a result, a columnar internal space 61 g that is long in the vertical direction is formed in the housing 61, and a diaphragm 62 is arranged in the internal space 61 g.

The diaphragm 62 is a flexible film-like member, and is formed in a substantially hemispherical shape. A flange 62a is formed at the open end of the diaphragm 62 over the entire circumference in the circumferential direction, and the flange 62a is arranged between the lower housing portion 61a and the upper housing portion 61b. More specifically, the hole diameter of the opening end of the upper housing portion 61b is larger than the hole diameter of the remaining portion, and the inner peripheral surface of the opening end of the upper housing portion 61b has a step over the entire circumference in the circumferential direction. The surface 61f is formed. The open end (butting surface of the first housing) of the lower housing portion 61a is arranged so as to abut against the stepped surface 61f (butting surface of the second housing). The flange 62a of the diaphragm 62 is arranged between the open end of the lower housing portion 61a and the stepped surface 61f, and is sandwiched between the open end and the stepped surface 61f and fixed to the housing 61.

The diaphragm 62 fixed in this way projects toward the upper housing portion 41b in the initial state. In the present embodiment, since the drip chambers 14A and 15A are arranged on the downstream side of the blood pump 12, the diaphragm 62 projects toward the upper housing portion 41b in the initial state, but the drip chambers 14A and 15A have blood. When arranged on the upstream side of the pump 12, the diaphragm 62 is arranged so as to project toward the lower housing portion 41a (see the alternate long and short dash line in FIG. 9). Further, the diaphragm 62 divides the internal space 61 g of the housing 61 into two chambers, a blood chamber 65 and a gas chamber 66.

The blood chamber 65 is a chamber located on the bottom side of the housing portion 61a below the diaphragm 62, and is connected to the inflow hole 61c and the outflow hole 61d. Therefore, in the blood chamber 65, the blood flowing through the blood circuit 11 flows into the inflow hole 61c, and the blood in the blood chamber 65 flows out from the outflow hole 61d. As a result, the blood chamber 65 is filled with blood. The blood chamber 65 does not necessarily have to be filled with blood and may contain air bubbles or air, but filling with blood can prevent the formation of a thrombus. On the other hand, the gas chamber 66 is a chamber located on the housing portion 61b side above the diaphragm 62, and air can be supplied from the connection port 61e. The air in the gas chamber 66 is pushed from the blood in the blood chamber 65 through the diaphragm 62, or pushes the blood in the blood chamber 65. By doing so, the flexible diaphragm 62 changes its position according to the internal pressure of the blood chamber 65 and the internal pressure of the gas chamber 66 (see, for example, the alternate long and short dash line in FIG. 9).

Further, an air bleeding hole 61h is formed on the outer peripheral surface of the lower housing portion 61a, and the air bleeding hole 61h is opened to the atmosphere via the air bleeding line 24 (or the air bleeding line 25). Further, the air vent hole 61h is connected to the blood chamber 65, and the air contained in the blood of the blood chamber 65 is discharged to the atmosphere. Further, an air tube 43 is inserted into the connection port 61e of the upper housing portion 61b. The air tube 43 is connected to the adjusting device main body 32 described later via the female connector portion 44, and air is supplied from the adjusting device main body 32 to the gas chamber 66 via the air tube 43. ..

The drip chambers 14A and 15A configured in this way play a role similar to that of the pressure measuring instrument 31. That is, it is used to measure the pressure of blood flowing through the blood circuit 11 (that is, the internal pressure of the blood chamber 65). Further, in the drip chambers 14A and 15A, the position of the diaphragm 62 can be adjusted by the adjusting device main body 32 in the same manner as the pressure measuring instrument 31, which is the same as the film position adjusting process of the first embodiment. The position of the diaphragm 62 can be estimated and adjusted by the procedure. In this way, since the drip chambers 14A and 15A can have the same function as the pressure measuring instrument 31, the second pressure measuring instrument 31d and the third pressure measuring instrument 31m can be omitted, and the film position adjustment can be performed. The number of parts of the device 1A can be reduced.

Further, in the drip chambers 14A and 15A, the gas amount adjuster 34 is connected to the connection port 61e of the gas chamber 66 via the adjustment line 37 and the air tube 43, and the pressure sensor 35 is based on the pressure of the adjustment line 37. Is designed to output a signal. Therefore, it is not necessary to separately connect the detection line for the pressure sensor 35 to the drip chambers 14A and 15A, and it is possible to prevent the detection line from being accidentally connected to another port.

In addition, the film position adjusting device 1A of the second embodiment has the same effect as that of the film position adjusting device 1 of the first embodiment.

<Third Embodiment>
As shown in FIG. 8, the film position adjusting device 1B has drip chambers 14B and 15B, and the drip chambers 14B and 15B have a configuration similar to that of the drip chambers 14A and 15A. In the following, the configurations of the drip chambers 14B and 15B will be mainly described only for different configurations, and the same configurations will be designated by the same reference numerals and description thereof will be omitted. Further, since the drip chambers 14B and 15B have the same configuration, the configuration of the drip chamber 14B will be specifically described with reference to FIG. 10, and the description of the configuration of the drip chamber 15B will be omitted.

As shown in FIG. 10, it has a housing 61, a mounting member 71, a diaphragm 62, an air tube 43, and a female connector portion 44. The mounting member 71 is a member for arranging the diaphragm 62 in the housing 61, and divides the internal space 61 g of the housing 61 into an upper space 72 which is a first space and a lower space 73 which is a second space. Is arranged in the housing 61. More specifically, the mounting member 71 has a pair of plates 74, 75. The pair of plates 74 and 75 are formed in the same shape and have a circular shape in a plan view. Further, each of the plates 74 and 75 is formed with diaphragm mounting holes 74a and 75a and tube mounting holes 74b and 75b at the same positions in a plan view, and when the pair of plates 74 and 75 are overlapped in the vertical direction, diaphragm mounting is performed. The holes 74a and 75a overlap each other, and the tube mounting holes 74b and 75b overlap each other.

A substantially hemispherical diaphragm 62 is arranged on the lower plate 74 so as to project downward from the diaphragm mounting hole 74a, and the flange 62a of the diaphragm 62 is placed on the inner peripheral edge around the diaphragm mounting hole 74a. ing. Further, the upper plate 75 is placed on the lower plate 74 so that the diaphragm mounting hole 75a overlaps the diaphragm mounting hole 74a in a plan view, and the inner peripheral edge of the diaphragm mounting hole 75a is inside the diaphragm mounting hole 74a. The flange 62a of the diaphragm 62 is sandwiched together with the peripheral edge. When the portion of the diaphragm 62 sandwiched in this way is lifted upward except for the flange 62a, the portion protrudes upward from the diaphragm mounting hole 75a of the upper plate 75 (FIG. 10-2). See dotted line).

Further, by placing the upper plate 75 on the lower plate 74, the tube mounting hole 74b overlaps the tube mounting hole 75b in a plan view, and the air bleeding line 24 is provided in the tube mounting holes 74b and 75b. Is inserted. The opening on the distal end side of the air bleeding line 24 faces the blood chamber 65 and is substantially flush with the lower surface of the lower plate 74. Further, the tip end side portion of the air bleeding line 24 is fixed and integrated with the plate 74 by a solvent adhesive or the like to prevent air from entering the gas chamber 66 from the tube mounting hole 74b. The air bleeding line 24 does not necessarily have to be fixed to the plate 74. For example, a sealing member such as an O-ring is provided so as to surround the tube mounting hole 74b so that the sealing member is sandwiched between a pair of plates 74 and 75, or a flange-shaped protrusion is provided on the tip end side of the air bleeding line 24 to form a pair. The gas chamber 66 and the blood chamber 65 may be fixed while being sandwiched by the plates 74 and 75 of the above.

The air bleeding line 24 arranged in this way protrudes to the outside of the housing 61 through the gas chamber 66, and the blood chamber 65 is connected to the external space of the housing 61 by the air bleeding line 24 and is opened to the atmosphere. ing. As a result, the air trapped in the blood chamber 65 and rising to the lower surface of the lower plate 74 can be released to the atmosphere through the air tube 43. On the other hand, at the time of pressure measurement or the like, the air bleeding line 24 is closed by a clamp member (not shown), and the blood circuit 11 can be sealed by closing the air bleeding line 24.

In addition, the film position adjusting device 1B of the third embodiment has the same effect as that of the film position adjusting device 1A of the second embodiment.

<Fourth Embodiment>
The blood purification system 2C including the membrane position adjusting device 1C of the fourth embodiment includes the blood circuit 11, the blood pump 12, the blood purifying machine 13, and the two drip chambers 14, 15 together with the membrane position adjusting device 1C. It includes a priming liquid supply device 16, three valves 17 to 19, and a film position adjusting device 1C. The blood pump 12 is, for example, a roller pump, and has a roller 12a capable of forward rotation and reverse rotation. The blood pump 12 sends the liquid in the blood circuit 11 in a direction (that is, a forward direction or a reverse direction) according to the rotation direction of the roller 12a.

More specifically, the blood pump 12 has a part of the blood circuit 11 mounted therein, and the part thereof is squeezed by the roller 12a. By squeezing, the liquid in the blood circuit 11 on the upstream side in the forward direction (or upstream side in the reverse direction) from the blood pump 12 is sucked into the part thereof and sent out to the downstream side in the forward direction (or upstream side in the reverse direction). Is done. In this way, the blood pump 12 sends the liquid in the blood circuit 11 from the upstream side in the forward direction (or the upstream side in the reverse direction) to the downstream side in the forward direction (or the upstream side in the reverse direction). Therefore, by connecting both ends of the blood circuit 11 to each of the patient's arteries and veins and moving the blood pump 12 so that the roller 12a rotates in the forward direction, the blood in the arteries is drained into the blood circuit 11 and returned to the veins. You can get blood. In addition, when it is simply referred to as "upstream side" and "downstream side" in the following, it indicates a forward side upstream side and a forward direction downstream side.

The blood purification system 2C configured in this way has two pressure measuring instruments 31 for measuring the pressure of blood flowing through the blood circuit 11. The pressure measuring instrument 31 is located on the upstream side of the blood purifier 13 between the upstream opening / closing valve 18 and the blood pump 12, and on the downstream side of the blood purifying machine 13 between the downstream drip chamber 15 and the downstream opening / closing. It is arranged between the valve 19 and the valve 19. In the pressure measuring instrument 31 of the blood purification system 2C, the gas chamber 46 is sealed and filled with air, and the position of the diaphragm 42 changes as the air in the gas chamber 46 expands and contracts. That is, the diaphragm 42 is pushed by the blood of the blood chamber 45 and the air of the gas chamber 46 to change its position, and moves to a position where the internal pressure of the blood chamber 45 and the internal pressure of the gas chamber 46 are in equilibrium. It has become. As a result, the flexible diaphragm 42 changes its position according to the internal pressure of the blood chamber 45 and the internal pressure of the gas chamber 46, and is separated from the inner peripheral surface of the upper housing portion 41b as shown in FIG. 3, for example. ing.

Further, the detection line 81 is inserted into the connection port 41e of the housing 41. The detection line 81 is a hollow tube, one end of which is inserted into the connection port 41e of the housing 41. Further, as shown in FIG. 11, a pressure sensor 35 is connected to the other end of the detection line 81, and air having the same pressure as the gas chamber 46 is guided to the pressure sensor 35 via the detection line 81. ing. The pressure sensor 35 converts the pressure of the guided air into a pressure signal and outputs the pressure signal. That is, the pressure sensor 35 outputs a pressure signal corresponding to the internal pressure of the gas chamber 46.

Further, an open-air line 82 is connected to the detection line 81. One end of the open-air line 82 is connected to the detection line 81, and the other end is open to the atmosphere. Further, the open valve 83 is provided on the atmospheric open line 82. The opening valve 83 is a so-called electromagnetic opening / closing valve, and can input an opening / closing signal for opening to the atmosphere. The opening valve 83 opens and closes the atmosphere opening line 82 according to the input state of the opening / closing signal for opening to the atmosphere.

As described above, the pressure measuring instrument 31 configured in this way is provided on the upstream side and the downstream side of the blood purifier 13 in the blood circuit 11, respectively. In the following, the pressure measuring instrument 31 arranged on the upstream side may be referred to as an upstream pressure measuring instrument 31u, and the pressure measuring instrument 31 arranged on the downstream side may be referred to as a downstream pressure measuring instrument 31d. is there. Further, regarding the pressure sensor 35, the detection line 81, the atmosphere opening line 82, and the opening valve 83, those connected to the upstream pressure measuring instrument 31u are also the upstream pressure sensor 35u, the upstream detection line 81u, and the upstream atmosphere. The opening line 82u and the upstream opening valve 83u, which are connected to the downstream pressure measuring instrument 31d, are also the downstream pressure sensor 35d, the downstream detection line 81d, the downstream atmospheric opening line 82d, and the downstream opening. It may be referred to as a valve 83d. Further, the blood purification system 2C has a blood pump 12 and a controller 36C for controlling the movements of the valves 17 to 19, 26, 27, 83u and 83d.

A pressure sensor 35 is electrically connected to the controller 36C, and a pressure signal output from the pressure sensor 35 is input to the controller 36C. The internal pressure of each gas chamber 46 of each of the downstream pressure measuring instruments 31u and 31d is detected. That is, the controller 36C detects the pressure of blood in the blood chamber 45 (that is, the internal pressure of the blood chamber 45) based on the pressure signals from the pressure sensors 35u and 35d. Further, the controller 36C is electrically connected to each of the five valves 17 to 19, 26, 27, the blood pump 12, and the alarm 50, similarly to the controller 36 of the first to third embodiments. , They are designed to control their movements.

In the blood purification system 2C configured in this way, both ends of the blood circuit 11 are connected to the arteries and veins of the patient, and the controller 36C drives the blood pump roller 12a so that blood flows from the arteries to the veins. Therefore, the upstream pressure measuring instrument 31u moves in the same manner as the first pressure measuring instrument 31u of the first embodiment, and the downstream pressure measuring instrument 31d is the third pressure measuring instrument 31d of the first embodiment. It works in the same way. That is, the internal pressure of the blood chamber 45 of each of the pressure measuring instruments 31u and 31d is converted into an air pressure by the diaphragm 42, and this air pressure is converted into a pressure signal by the pressure sensor 35. Then, the controller 36C can detect the internal pressure of the blood chamber 45 by detecting the pressure from the pressure signal.

Further, in the diaphragm 42, when detecting the negative pressure, it is preferable to arrange the main body portion 42b at the upper limit position as in the case of the first pressure measuring instrument 31u of the first embodiment, and when detecting the positive pressure, the first It is preferable to arrange the main body portion 42b at the lower limit position as in the second pressure measuring instrument 31d of the embodiment. As described above, since the pressure measuring instrument 31 protrudes to either the lower housing portion 41a or the upper housing portion 41b at the time of manufacture, in the blood purification system 2C, the normal position according to the placement position after priming. In order to adjust the position of the diaphragm 42 of each of the pressure measuring instruments 31u and 31d, the controller 36C executes the film position adjusting process. Hereinafter, the film position adjusting process will be described with reference to FIG.

In the membrane position adjusting process, for example, the vicinity of the end portion of the blood circuit 11 on the arterial side is closed by the opening / closing valve 18, and the other end portion of the blood circuit 11 is connected to the tank via a collection line (not shown). After that, when a priming command is input to the controller 36C by an input device (not shown), the process starts and the process proceeds to step S31. In step S31, which is a priming step, priming is performed. That is, the controller 36C outputs a priming line open / close signal to the priming open / close valve 17 to open the priming line 23 and drive the blood pump 12. As a result, the priming liquid is sucked from the priming liquid supply device 16 into the blood pump 12 via the arterial side portion of the blood circuit 11, and further supplied from the blood pump 12 to the venous side portion of the blood circuit 11 through the blood purifier 13. Will be done. As a result, the priming liquid is guided from the priming liquid supply device 16 to the tank via the recovery line. As a result, the air in the blood circuit 11 and the blood purifier 13 is discharged to the atmosphere from the collection lines and the air bleeding lines 24 and 25, and the blood circuit 11 and the blood purifier 13 are filled with the priming liquid. When priming is performed in this way, the process proceeds to step S32.

In step S32, which is a priming end determination step, it is determined whether or not priming has been completed. That is, the controller 36C flows a priming liquid having a specified amount of liquid, and determines the presence or absence of bubbles remaining in the blood circuit 11 by a bubble sensor (not shown). If it is determined that there are air bubbles, it is assumed that the priming has not been completed, and the process returns to step S31 to continue the priming. On the other hand, when it is determined that there are no bubbles, the controller 36C stops the blood pump 12 and ends the priming, assuming that the blood circuit 11 and the blood purifier 13 are sufficiently filled with the priming liquid. When the priming is completed, the process proceeds to step S33.

In step S33, which is a clamping step, the priming line 23 and the air bleeding lines 24 and 25 are closed by the three valves 17, 26 and 27. That is, the controller 36C inputs a priming line opening / closing signal to the priming opening / closing valve 17 to close the priming line 23, and inputs an opening / closing signal to the air bleeding opening / closing valves 26 and 27, respectively, to bleed the air lines 24 and 25. Close. Further, the controller 36C inputs an opening / closing signal for opening and closing the atmosphere to each of the opening valves 83u and 83d to close the upstream and downstream atmospheric opening lines 82u and 82d. When the upstream and downstream atmospheric open lines 82u and 82d are closed in this way, the process proceeds to step S34.

In step S34, which is an instrument selection step, the controller 36C selects an instrument for adjusting the position of the diaphragm 42 from the two pressure measuring instruments 31u and 31d. For example, when the parameter m whose initial value is 0 is 0, the controller 36C selects the upstream pressure measuring instrument 31u and adds 1 to the parameter m. On the other hand, when the parameter m is 1, the controller 36C selects the downstream pressure measuring instrument 31d and adds 1 to the parameter m. When the upstream pressure measuring instrument 31u is selected, the process proceeds to step S36, and when the downstream pressure measuring instrument 31d is selected, the process proceeds to step S35.

In step S35, which is the second clamping step, the vicinity of the other end of the blood circuit 11 is closed by the downstream opening / closing valve 19. More specifically, the controller 36C inputs a downstream opening / closing signal to the downstream opening / closing valve 19 to close the vicinity of the other end of the blood circuit 11. At this time, one end of the blood circuit 11 is connected to a tank for priming liquid via a collection line (not shown). When the vicinity of the other end of the blood circuit 11 is closed in this way, the process proceeds to step S36.

In step S36, which is a pressure detection step, the blood pump 12 is driven to send the priming liquid in the blood circuit 11, and the change in pressure in the gas chamber 46 selected from the two pressure measuring instruments 31u and 31d is detected. It is a process. Specifically, the controller 36C reversely rotates the roller 12a of the blood pump 12 so that the priming liquid flows from the other end side to the one end side of the blood circuit 11. As a result, the priming liquid is sucked from the blood chamber 45 of the downstream pressure measuring instrument 31d into the blood pump 12, and the priming liquid is sent into the blood chamber 45 of the upstream pressure measuring instrument 31u.

When the device selected is the upstream pressure measuring device 31u, the vicinity of one end of the blood circuit 11 is closed. Therefore, when the priming solution is sent to the blood chamber 45 of the upstream pressure measuring device 31u, the blood chamber The position of the diaphragm 42 changes so that the 45 expands. As a result, the air in the gas chamber 46 is compressed. On the other hand, when the selected device is the downstream pressure measuring device 31d, the priming solution is sucked from the blood chamber 45 of the downstream pressure measuring device 31d because the vicinity of the other end of the blood circuit 11 is closed. Then, the position of the diaphragm 42 changes so that the blood chamber 45 contracts. As a result, the air in the gas chamber 46 expands. Since the blood chambers 45 of the pressure measuring instruments 31u and 31d that are not selected are connected to the tank via the collection line, the volume does not change even if the priming solution flows in or is sucked, and the diaphragm. The position of 42 does not change. When the air in the gas chamber 46 is expanded and contracted as described above, the controller 36C applies the internal pressure of the gas chamber 46 based on the pressure signal from the pressure sensor 35 connected to the selected pressure measuring instruments 31u and 31d. To detect. When the internal pressure of the gas chamber 46 is detected, the process proceeds to step S37.

In step S37, which is a pressure determination step, it is determined whether or not the detected internal pressure has converged to a substantially constant value. In the pressure measuring instrument 31, the main body portion 42b of the diaphragm 42 is formed to match the shape of the inner peripheral surface of the lower housing portion 41a and the inner peripheral surface of the upper housing portion 41b, and the main body portion 42b of the diaphragm 42 is formed. It can move along each inner peripheral surface. That is, the main body portion 42b can move to the upper limit position and the lower limit position where the main body portion 42b sticks to the inner peripheral surfaces of the housing portions 41b and 41a, and when the main body portion 42b reaches the upper limit position or the lower limit position, the main body portion 42b is further increased. The volume of the gas chamber 46 does not change even if an amount of priming liquid is sucked or sent.

The gas chamber 46 forms a closed system space 84 together with the detection line 81 and the passage in the atmosphere opening line 82 when the atmosphere opening line 82 is closed, and the internal pressure of the gas chamber 46 is shown in the graphs of FIGS. 5 and 6. As shown, it basically changes based on Boyle's law shown in equation (2).

Here, P ₀ is the pressure (that is, atmospheric pressure) of the gas chamber 46 in the initial state before suction or supply, and P _x is the pressure detected by the pressure sensor 35. Further, V is the volume of the closed system space 84, and V _x is the amount of the priming liquid sucked or sent by the blood pump 12. _{Further, the graph of FIG. 13 shows the relationship between the supply flow rate V x} of the priming liquid in the upstream pressure measuring instrument 31u and the detected pressure P _x, and the graph of FIG. 14 shows the priming liquid in the downstream pressure measuring instrument 31d. The relationship between the suction flow rate V _x and the detection pressure P _x is shown.

Since the internal pressure of the gas chamber 46 changes based on Boyle's law, the internal pressure of the gas chamber 46 does not change when the volume of the gas chamber 46 does not change, and even if the priming liquid is sucked or sent by the blood pump 12. The internal pressure of the gas chamber 46 becomes substantially constant. That is, by determining that the internal pressure detected by the sensors 35u and 35d has converged to a substantially constant value, it can be confirmed that the main body portion 42b is arranged at the upper limit position or the lower limit position. Whether or not the pressure is converged is determined by, for example, the internal pressure detected by the pressure sensors 35u and 35d being within a predetermined range for a predetermined time. If it is determined that the detected internal pressure has not converged to a substantially constant value, the process returns to step S36, and the blood pump 12 is driven to continue detecting the internal pressure until the detected internal pressure converges to a substantially constant value. Then, when the detected internal pressures both converge to a substantially constant value, the process proceeds to step S38.

In step S38, which is a pump stopping step, the blood pump 12 is stopped to stop the feeding of the priming liquid. That is, the controller 36C stops the movement of the roller 12a of the blood pump 12. When the movement of the blood pump 12 is stopped, the process proceeds to step S39. In step S39, which is an air opening step, the air opening lines 82u and 82d connected to the selected pressure measuring instruments 31u and 31d are opened by the opening valves 83u and 83d, and the gas chamber 46 of the selected pressure measuring instruments 31u and 31d is opened. Return the internal pressure to atmospheric pressure. By returning the internal pressure of the gas chamber 46 to atmospheric pressure, the diaphragm 42 can be kept in the normal position. When the internal pressure of the gas chamber 46 is returned to the atmospheric pressure, the process proceeds to step S40. In step S9, before the internal pressure of the gas chamber 46 is returned to the atmospheric pressure, the roller 12a of the blood pump 12 is rotated forward by the controller 36C until the internal pressure starts to fluctuate to reduce the internal pressure of the blood chamber 45. You may. As a result, the internal pressure of the blood chamber 45 that has been excessively lowered in step S9 can be brought close to the atmospheric pressure, and the difference between the internal pressure of the blood chamber 45 and the internal pressure of the gas chamber 46 can be reduced.

In step S40, which is a blood circuit opening step, the blood circuit 11 is opened to the atmosphere. That is, the controller 36C outputs an opening / closing signal to the air bleeding opening / closing valves 26 and 27 to open the air bleeding lines 24 and 25. As a result, the blood circuit 11 is opened to the atmosphere, and the inside of the blood circuit 11 returns to atmospheric pressure. Further, the controller 36C outputs an upstream or downstream opening / closing signal to the opening / closing valves 18 and 19 according to the numerical value of the parameter m to open the blood circuit 11. More specifically, when the parameter m is 1, an upstream opening / closing signal is output to the upstream opening / closing valve 18 to open the vicinity of one end of the blood circuit 11. On the other hand, when the parameter m is 2, a downstream opening / closing signal is output to the downstream opening / closing valve 19 to open the vicinity of the other end of the blood circuit 11. When the vicinity of one end or the other end of the blood circuit 11 is opened in this way, the process proceeds to step S41.

In step S41, which is the adjustment end determination step, it is determined whether to end or continue the diaphragm adjustment process. More specifically, the controller 36C is adapted to determine whether to end or continue the diaphragm adjusting process according to the numerical value of the parameter m. That is, when the parameter m is 1, the controller 36C determines that the position adjustment of the diaphragm 42 of the downstream pressure measuring instrument 31d has not been completed, and returns to step S3. On the other hand, when the parameter m is 2 or more, the controller 36C determines that the position adjustment of the diaphragm 42 of the pressure measuring instruments 31u and 31d is completed, and the film position adjustment process is completed.

The membrane position adjusting device 1C of the present embodiment is a normal position (that is, an upper limit position or a lower limit position) according to the arrangement position of the pressure measuring instruments 31u and 31d by moving the priming liquid in the blood circuit 11 with the blood pump 12. Each diaphragm 42 can be adjusted. In the membrane position adjusting device 1C, a priming liquid which is an incompressible fluid is used for adjusting the diaphragm 42. Therefore, the position of the diaphragm 42 can be adjusted by the priming liquid having less expansion and contraction due to individual differences in the shapes of the pressure measuring instruments 31u and 31d, temperature, and the like. As a result, the diaphragm 42 can be moved to a position according to the amount of liquid flowing into or being sucked into the blood chamber 45 without being affected by individual differences in the shapes of the pressure measuring instruments 31u and 31d, temperature, and the like. It is possible to improve the positional accuracy of the diaphragm 42 when adjusting the position of the diaphragm 42.

Further, in the membrane position adjusting device 1C, the priming liquid does not expand or contract when flowing into or sucking into the blood chamber 45 of the pressure measuring instruments 31u and 31d, so that the same amount of air flows into the gas chamber 46 or The diaphragm 42 can be moved more than when aspirated. Therefore, the diaphragm 42 can be moved to the normal position with a smaller amount of priming liquid than air, and the adjustment time when adjusting the position of the diaphragm 42 to the normal position can be shortened.

Further, in the membrane position adjusting device 1C, since the membrane position adjusting process can be executed by the blood pump 12, the position of the diaphragm 42 can be adjusted without adding a new configuration. That is, the position of the diaphragm 42 can be adjusted without increasing the number of parts. Further, it is not necessary to adjust the film position at the time of manufacturing, and the adjustment of the film position at the time of manufacturing can be omitted. Therefore, the film position adjustment work that is artificially performed can be omitted, and the manufacturing cost associated with the artificial work can be reduced.

Further, in the membrane position adjusting device 1C, the diaphragm 42 of the upstream pressure measuring instrument 31u is arranged at the upper limit position which is the normal position, and the diaphragm 42 of the downstream pressure measuring instrument 31d is arranged at the lower limit which is the normal position. Will be done. As a result, the movable range of the diaphragm 42 at the time of measurement can be increased, the range of negative pressure that can be measured by the upstream pressure measuring instrument 31u can be increased, and the measurement can be performed by the downstream pressure measuring instrument 31d. The range of possible positive pressure can be increased. Further, since the measurable range can be made large, the internal space 41 g of the housing 41 can be made smaller than that of a pressure measuring instrument capable of measuring both negative pressure and positive pressure, and the size of the housing 41 can be increased. It is possible to reduce the size.

Further, in the blood purification system 2C of the present embodiment, the position of the diaphragm 42 is detected and adjusted after the priming is performed. Therefore, even if the position of the diaphragm 42 of the pressure measuring instruments 31u and 31d fluctuates when the priming liquid is circulated, the position of the diaphragm 42 can be adjusted to the normal position before performing blood purification. Thereby, the pressure of blood flowing in the blood circuit 11 at the time of blood purification can be measured in a wide range.

<Fifth Embodiment>
The membrane position adjusting device 1D of the fifth embodiment has the same configuration as the membrane position adjusting device 1C of the fourth embodiment and is provided in the blood purification system 2C, but the membrane position adjusting device of the fourth embodiment is provided. The position of the diaphragm 42 is adjusted by a method different from that of 1D. More specifically, the position of the diaphragm 42 is estimated and the position of the diaphragm 42 is adjusted based on the estimation result. Hereinafter, a method in which the controller 36 of the membrane position adjusting device 1D of the fifth embodiment adjusts the diaphragm 42, that is, the membrane position adjusting process will be specifically described with reference to FIG. The configuration of the film position adjusting device 1D of the fifth embodiment is designated by the same reference numerals as those of the film position adjusting device 1C of the fourth embodiment, and the description thereof will be omitted.

In the membrane position adjusting process, as in the case of the membrane position adjusting device 1C, for example, when one end of the blood circuit 11 is closed by the upstream opening / closing valve 18, a priming command is input to the controller 36 by an input device (not shown). It is started, and the process proceeds to step S31, which is a priming step, and priming is performed. When priming is performed, the process proceeds to step S32, which is a priming end determination step, and the controller 36C determines whether or not priming is completed. If it is determined that there are air bubbles, it is assumed that the priming has not been completed, and the process returns to step S31 to continue the priming. On the other hand, if it is determined that there are no bubbles, it is assumed that priming has been completed, and the process proceeds to step S33.

In step S33, which is the first clamping step, the priming line 23, the blood circuit 11, and the air bleeding line 24, 25 are closed by the three valves 17, 26, 27. Further, the controller 36C closes the upstream and downstream atmospheric opening lines 82u and 82d by the upstream opening valves 83u and 83d. When the upstream and downstream atmospheric open lines 82u and 82d are closed, the process proceeds to step S34. In step S34, which is an instrument selection step, the instrument for adjusting the position of the diaphragm 42 by the controller 36C is selected from the two pressure measuring instruments 31u and 31d according to the parameters, and 1 is added to the parameter m. When the parameter m is 0 and the upstream pressure measuring instrument 31u is selected, the process proceeds to step S46, and when the parameter m is 1 and the downstream pressure measuring instrument 31d is selected, the process proceeds to step S35. To do.

In step S35, which is the second clamping step, a downstream opening / closing signal is input to the downstream opening / closing valve 19 to close the vicinity of the other end of the blood circuit 11. At this time, a tank for the priming liquid is connected to one end of the blood circuit 11 via a collection line (not shown). When the vicinity of the other end of the blood circuit 11 is closed, the process proceeds to step S56. In step S56, which is the number reset step, the pressure detection number n is set to zero. When the pressure detection number n becomes zero, the process proceeds to step S57.

In step S57, which is the pressure detection step, the pressure detection process is executed. The pressure detection process is a process of detecting the pressure after the change by changing the amount of the priming solution in the blood chamber 45 of the selected pressure measuring instruments 31u and 31d. More specifically, the controller 36C rotates the roller 12a of the blood pump 12 in the forward direction so that the priming liquid flows from one end side to the other end side of the blood circuit 11. As a result, the priming liquid is sucked from the blood chamber 45 of the upstream pressure measuring instrument 31u, and the priming liquid is sent to the blood chamber 45 of the downstream pressure measuring instrument 31d. Further, the controller 36 detects the internal pressure of the gas chamber 46 in the selected pressure measuring instruments 31u and 31d. In the following, the pressure detection process will be described in more detail with reference to FIG.

When the pressure detection process is executed, step S61 is started. At step S61 a delivery process, the controller 36C sends a priming fluid of the set flow rate V ₀ which is predetermined in the blood circuit 11 and drives the blood pump 12. That is, the controller 36C rotates the roller 12a of the blood pump 12 in the forward direction by a preset rotation angle θ. _{As a result, the priming liquid having the set flow rate V 0} , which is the flow rate corresponding to the set rotation angle θ of the roller 12a, is sent from the upstream side to the downstream side of the blood pump 12. As a result, the priming liquid having the set flow rate V ₀ is sucked from the blood chamber 45 of the upstream pressure measuring instrument 31u, and _{the priming liquid having the set flow rate V 0} is supplied to the blood chamber 45 of the downstream pressure measuring instrument 31d. To.

When the device selected is the upstream pressure measuring device 31u, the vicinity of one end of the blood circuit 11 is closed and the priming liquid in the blood chamber 45 of the upstream pressure measuring device 31u is sucked, so that the gas chamber 46 The position of the diaphragm 42 changes so that the air expands. On the other hand, when the device selected is the downstream pressure measuring device 31d, the vicinity of the other end of the blood circuit 11 is closed and the priming solution flows into the blood chamber 45 of the downstream pressure measuring device 31d, so that the gas chamber. The position of the diaphragm 42 changes so that the air of 46 is compressed. Since the blood chamber 45 of the unselected device is connected to the tank via a collection line, the volume does not change even if the priming solution flows in or is sucked, and the position of the diaphragm 42 changes. Never. When the position of the diaphragm 42 of the selected pressure measuring instruments 31u and 31d is changed, the process proceeds to step S62.

In step S62, which is a pressure detecting step, the signal is selected based on the pressure measurement instrument 31u from the pressure sensor 35, the internal pressure _{P x} in the gas chamber 46 of 31d controller 36C detects. The controller 36C uses the detected internal pressure (hereinafter, also referred to as “detected pressure”) P _{x as the flow rate V x} (= predetermined flow rate V ₀ ) of the priming liquid flowed by the blood pump 12 after n is reset in step S16. × (n + 1)) and the selected pressure measuring instruments 31u and 31d are stored in the controller 36C in association with each other. When stored in the controller 36C, the pressure detection process ends and the process proceeds to step S48.

In step S48, which is the detection number counting step, 1 is added to the pressure detection number n. When 1 is added to the pressure detection number n, the process proceeds to step S49. In step S49, which is the specified number of times determination step, the controller 36 determines whether the pressure detection number n is equal to or greater than the specified number of times a. In the present embodiment, the specified number of times a is three times, but it may be two times or less or four times or more. When it is determined that the pressure detection number n is equal to or less than the specified number a, the process returns to step S47, and pressure detection is performed until the pressure detection number n exceeds the specified number a. In the pressure detection process, priming fluid of the set flow rate V ₀ every time the detection processing of the pressure is carried out is adapted to be supplied. That is, the controller 36C rotates the roller 12a positively by a preset rotation angle θ minutes when n = 0, and rotates the roller 12a positively by a preset rotation angle θ minutes each time the pressure detection number n increases. Let me. As a result, when the number of pressure detections is n, the roller 12a rotates in the reverse direction by a rotation angle of θ × n, and _{the priming liquid having a flow rate of V 0} × n (= flow rate V _× ) corresponding to the rotation angle of θ × n is applied to the pressure measuring instruments 31u and 31d. It is aspirated or supplied to the blood chamber 45. When the pressure detection process is repeated and the pressure detection number n exceeds the specified number a, the process proceeds to step S50.

In step S50, which is a correlation determination step, it is determined whether or not the relationship between _{the flow rate V x of the} priming liquid and the detection pressure P _{x has a correlation with a preset predetermined relationship.} In each of the pressure measuring instruments 31u and 31d, the position of the diaphragm 42 changes according to the amount of liquid in the blood chamber 45, that is, the volume of the blood chamber 45, and the volume of the gas chamber 46 changes due to the change in the position of the diaphragm 42. Change. The gas chamber 46 forms a closed space 84 together with the detection line 81 and the passage in the atmosphere opening line 82, and the air in the gas chamber 46 expands or is compressed according to Boyle's law. That is, assuming that the volume of the closed system space 84 in the initial state (that is, when the internal pressure of the closed system space 84 is atmospheric pressure P ₀ ) is the volume V, the detected detection pressure P _x is expressed by the following equation (3). Shown. The formula (3) is the same formula as the above-mentioned formula (2).

In film position adjusting device 1D, the pressure detection processing has been performed after the priming step and clamping step, the internal pressure of the sealed system space 84 in the initial state in the pressure detection process, which is the atmospheric pressure P _0. On the other hand, the volume V (more specifically, the volume of the gas chamber 46) of the closed system space 84 in the initial state changes according to the initial position of the diaphragm 42. Therefore, the relationship between the flow rate V _{x of the} priming liquid and the detection pressure P _x changes according to the volume V of the closed system space 84 in the initial state, that is, the initial position of the diaphragm 42.

The graphs of FIGS. 17 and 18 show the relationship between the flow rate of the priming liquid (that is, the suction or supply flow rate) V _x and the detection pressure P _{x. More specifically, the graph of FIG. 17 shows the relationship between the suction flow rate V x} and the detection pressure P _x when the priming solution is sucked from the blood chamber 45 of the upstream pressure measuring instrument 31u, and the graph of FIG. 18 shows the relationship. The relationship between _{the supply flow rate V x} and the detection pressure P _x when the priming solution is supplied to the blood chamber 45 of the downstream pressure measuring instrument 31d is shown. The vertical axis of FIGS. 17 and 18 _{indicates the detected pressure P x} , and the horizontal axis indicates the suction or supply flow rate V _x .

_{For example, the relationship between the suction flow rate V x} and the detection pressure P _x shown by the solid lines a11 and ◇ in FIG. 17 is such that the diaphragm 42 protrudes toward the upper housing portion 41b in the initial state and follows the inner wall of the upper housing portion 41b. The above relationship is shown when the volume of the gas chamber 46 is approximately 0 ml (when the diaphragm 42 is arranged at a normal position in the negative pressure measurement type pressure measuring instrument 31). The relationships shown by the solid lines a11 and ◇ in FIG. 17 are relationships calculated by, for example, experiments, and are defined relationships in the upstream pressure measuring instrument 31u. The same applies to each relationship described below. _{The relationship between the suction flow rate V x} and the detection pressure P _x shown by the solid lines a12 and Δ in FIG. 17 is that the diaphragm 42 is arranged slightly away from the inner wall of the upper housing portion 41b in the initial state, and the volume of the gas chamber 46 is substantially reduced. This is the case when α ml (0 <α) is set. _{The relationship between the suction flow rate V x} and the detection pressure P _x shown by the solid lines a13 and □ in FIG. 17 is such that the diaphragm 42 is arranged slightly away from the inner wall of the upper housing portion 41b as compared with the case where the diaphragm 42 is the solid line a11 in the initial state. Moreover, it is arranged closer to the inner wall of the upper housing portion 41b as compared with the case of the solid line a12. That is, the volume of the gas chamber 46 in the initial state is the relationship between the _{suction flow rate V x} and the detection pressure P _{x when the volume is approximately β (0 <β <α) ml.}

_{On the other hand, the relationship between the supply flow rate V x} and the detection pressure P _x shown by the solid lines b11 and ◇ in FIG. 18 is such that the diaphragm 42 protrudes toward the lower housing portion 41a in the initial state and extends to the inner wall of the lower housing portion 41a. The above relationship is shown when the gas chamber 46 is arranged along the same direction and the volume of the gas chamber 46 is the maximum (when the diaphragm 42 is arranged at a normal position in the positive pressure measurement type pressure measuring instrument 31). The relationship shown by the solid line b11 and the point ◇ in FIG. 18 is a defined relationship in the downstream pressure measuring instrument 31d. _{Further, the relationship between the supply flow rate V x} shown by the solid line b12 and the point Δ in FIG. 18 and the detection pressure P _x is that the diaphragm 42 is arranged slightly away from the inner wall of the lower housing portion 41a in the initial state, and the gas in the initial state. This is the case where the chamber 46 is reduced by approximately γ ml from the case of the solid line b11. _{The relationship between the supply flow rate V x} and the detection pressure P _x shown by the solid lines b13 and □ in FIG. 18 is such that the diaphragm 42 is arranged slightly away from the inner wall of the lower housing portion 41a as compared with the case where the diaphragm 42 is the solid line b11 in the initial state. Moreover, it is arranged closer to the inner wall of the lower housing portion 41a as compared with the case of the solid line b12. That is, the gas chamber 46 in the initial state is reduced by approximately ε (0 <ε <γ) ml from the case of the solid line b11.

As can be seen from the graphs of FIGS. 17 and 18, if the volume of the gas chamber 46 in the initial state, that is, the initial position of the diaphragm 42 is different, the relationship between the _{suction or supply flow rate V x} and the detection pressure P _{x is different.} In step S20, it is determined whether or not the relationship between the suction or supply flow rate V _x and the detected pressure P _x has a correlation with the specified relationship, and the position of the diaphragm 42 is estimated. Hereinafter, the determination of the controller 36 regarding the presence or absence of correlation will be described in detail.

The controller 36C stores a plurality of specified pressures associated with different suction flow rates for negative pressure measurement. The specified pressure is a pressure value in a specified relationship as shown in the graph shown in FIG. 17, and is a pressure value when the volume is changed by _{a specified amount (for example, a set flow rate V 0).} That is, it is a point ◇ on the solid line a11 in FIG. Further, the controller 36C stores a plurality of specified pressures associated with different supply flow rates for positive pressure measurement. The specified pressure is a pressure value in a specified relationship as shown in the graph shown in FIG. 17, and is a pressure value when the volume of the blood chamber 45 is changed by _{a specified amount (for example, a set flow rate V 0).} That is, it is a point ◇ on the solid line b11 in FIG. Therefore, in the present embodiment, the controller 36C stores six specified pressures in advance.

In step S20, the controller 36C is selected for pressure measurement instrument 31u, a detection pressure P _x stored in association with the 31d, the type of the selected instrument (i.e., for a or positive pressure measuring negative pressure measurement by comparing the specified pressure is stored for each suction or supply flow rate V _x in association with), or not the detected pressure P _x and a specified pressure for all suction or supply flow rate V _x is the same value To judge. For example, in the case of the upstream pressure measuring instrument 31u, the detected pressure P _x and the specified pressure for negative pressure measurement _{are compared for each supply flow rate V x,} and in the case of the downstream pressure measuring instrument 31d, the detected pressure P _x and The specified pressure for positive pressure measurement is compared for each _{suction flow rate V x.} Whether or not the specified pressure and the detected pressure are the same does not necessarily mean that they are exactly the same, and the detected pressure is within a predetermined range based on the specified pressure. In some cases, it may be determined that they are the same. If they are the same, the controller 36C _{determines that the relationship between the suction or supply flow rate V x} and the detection pressure P _x has a correlation with the specified relationship. If it is determined that there is a correlation with respect to the selected pressure measuring instruments 31u and 31d, it is presumed that the diaphragm 42 is placed in the normal position. That is, when the selected instrument is the upstream pressure measuring instrument 31u, the diaphragm 42 is arranged along the inner wall of the upper housing portion 41b, and when the selected instrument is the downstream pressure measuring instrument 31d, the lower It is presumed that the diaphragm 42 is arranged along the inner wall of the side housing portion 41a, respectively. When it is estimated that the diaphragm 42 of the selected pressure measuring instruments 31u and 31d is arranged at the normal position, the process proceeds to step S38.

In step S38, which is a pump stopping step, the controller 36C stops the movement of the roller 12a of the blood pump 12 and stops the feeding of the priming liquid. When the feeding of the priming liquid is stopped, the process proceeds to step S39. In step S39, which is the opening step to the atmosphere, the controller 36C opens the opening lines 82u and 82d to the atmosphere by the opening valves 83u and 83d, and returns the internal pressure of the gas chamber 46 of the selected pressure measuring instruments 31u and 31d to atmospheric pressure. When the internal pressure of each gas chamber 46 is returned to the atmospheric pressure, the process proceeds to step S40. In step S40, which is a blood circuit opening step, the controller 36C opens the air bleeding lines 24 and 25 by the air bleeding opening / closing valves 26 and 27, and returns the pressure in the blood circuit 11 to atmospheric pressure. Further, the controller 36C outputs an upstream or downstream opening / closing signal to the opening / closing valves 18 and 19 according to the numerical value of the parameter m to open the blood circuit 11. When the blood circuit 11 is opened, the process proceeds to step S41. In step S41, which is the adjustment end determination step, the controller 36C determines whether to end or continue the diaphragm adjustment process according to the numerical value of the parameter m. When the parameter m is 1, the process returns to step S33 to adjust the position of the diaphragm 42 of the downstream pressure measuring instrument 31d, and when the parameter m is 2 or more, the membrane position adjusting process is completed.

Further, in step S20, when at least one detected pressure P _x is not the same as the specified pressure, the relationship between the suction or supply flow rate V _x and the detected pressure P _x does not have a correlation with the specified relationship, and the controller 36C Judges and presumes that the diaphragm 42 of the selected pressure measuring instruments 31u and 31d is not placed in the normal position. For example, in the case of the upstream pressure measuring instrument 31u, the diaphragm 42 is arranged on the lower housing portion 41a side (that is, the blood chamber 45 side) from the normal position, and in the case of the downstream pressure measuring instrument 31d, the diaphragm 42. Is presumed to be arranged on the housing portion 41b side (that is, the gas chamber 46 side) above the normal position. Then, the process proceeds to step S51 in order to adjust the diaphragm 42 of the selected pressure measuring instruments 31u and 31d to the normal position.

In step S51, which is the adjustment number determination step, the controller 36C determines whether the adjustment number i of the position of the diaphragm 42 exceeds the specified number b. The number of adjustments i is reset to zero each time the pressure measuring instruments 31u and 31d are selected. If the controller 36C determines that the number of adjustments i does not exceed the specified number of times b, the process proceeds to step S52. In step S52, which is the adjustment number counting step, 1 is added to the adjustment number i. When 1 is added to the adjustment number i, the process proceeds to step S53.

In step S53, which is the membrane position adjusting step, the priming solution is sucked or supplied to the blood chambers 45 of the pressure measuring instruments 31u and 31d selected according to the numerical value of the parameter m, and the selected pressure measuring instrument is selected. The position of the diaphragm 42 of 31u and 31d is adjusted. For example, when the parameter m is 1, the controller 36C reversely rotates the roller 12a of the blood pump 12 to supply the priming solution to the blood chamber 45 of the upstream pressure measuring instrument 31u. The controller 36C is a diaphragm 42 is pressed against the upper housing portion 41b side, it continues to drive the blood pump 12 to the detection pressure P _x in the upstream pressure measurement device 31u converges substantially constant. Then, the controller 36C stops the movement of the blood pump 12 _{when the detected pressure P x converges to be substantially constant.} As a result, the diaphragm 42 of the upstream pressure measuring instrument 31u is arranged along the inner peripheral surface of the upper housing portion 41b, that is, adjusted to a normal position. When the parameter m is 2, the controller 36C reversely rotates the roller 12a of the blood pump 12 to suck the priming liquid from the blood chamber 45 of the downstream pressure measuring instrument 31d. The controller 36C is a diaphragm 42 is pressed against the lower housing part 41a side, it continues to drive the blood pump 12 to the detection pressure P _x in the downstream pressure measuring instrument 31d converges substantially constant. Then, the controller 36C stops the movement of the blood pump 12 _{when the detected pressure P x converges to be substantially constant.} As a result, the diaphragm 42 of the downstream pressure measuring instrument 31d is arranged along the inner peripheral surface position of the lower housing portion 41a, that is, it is adjusted to the normal position. In this way, when the diaphragm 42 of the selected pressure measuring instruments 31u and 31d is adjusted to the normal position, the process proceeds to step S54.

In step S54, which is an open-air step, the controller 36C opens the open-air lines 82u and 82d by the open valves 83u and 83d to reduce the internal pressure of the gas chamber 46 of the selected pressure measuring instruments 31u and 31d, as in step S39. Return to atmospheric pressure. When the internal pressure of each gas chamber 46 is returned to the atmospheric pressure, the process proceeds to step S54. In step S55, which is a blood circuit opening step, the controller 36C opens the air bleeding lines 24 and 25 by the air bleeding opening / closing valves 26 and 27 as in step S10, and returns the pressure in the blood circuit 11 to atmospheric pressure. An upstream or downstream opening / closing signal is output to the opening / closing valves 18 and 19 according to the numerical value of the parameter m, and the blood circuit 11 is opened. When the blood circuit 11 is opened, the process proceeds to step S56.

In step S56, which is the third clamping step, the controller 36C closes the priming line 23 and the air bleeding lines 24 and 25 by the three valves 17, 26 and 27. Further, the controller 36C outputs an upstream or downstream opening / closing signal to the opening / closing valves 18 and 19 according to the numerical value of the parameter m, and closes the vicinity of one end or the other end of the blood circuit 11. .. More specifically, when the parameter m is 1, an upstream opening / closing signal is output to the upstream opening / closing valve 18 to close the vicinity of one end of the blood circuit 11. On the other hand, when the parameter m is 2, a downstream opening / closing signal is output to the downstream opening / closing valve 19 to close the vicinity of the other end of the blood circuit 11. When one end or the other end of the blood circuit 11 is closed in this way, the process proceeds to step S16. Then, the pressure is detected again in steps S47 to S49, and the presence or absence of correlation is determined in step S50. In step S50, it is determined again that there is no correlation, and in step S51, it is determined whether the number of adjustments i exceeds the specified number of times b. Here, if it is determined that the number of adjustments i exceeds the specified number of times b, the process proceeds to step S57.

In step S57, which is an alarm step, the alarm 50 notifies that the position cannot be adjusted due to a connection failure or a defect such as air leakage. That is, the controller 36C is connected when the detection pressure does not change and the detection pressure does not become the same as the specified pressure even if the position of the diaphragm 42 is repeatedly adjusted and the adjustment number i exceeds the specified number during suction or supply. It is judged that the position cannot be adjusted due to a defect such as a defect or air leakage. Then, the controller 36C sends a command to the alarm device 50 to notify an alarm that the position cannot be adjusted. Upon notification, the controller 36C stops the movement of each configuration of the blood pump 12 and the like. When the movement is stopped, the film position adjustment process is completed. After the film position adjustment process is completed, the above-mentioned problem is solved, and the film position adjustment process is restarted by inputting the restart of the film position adjustment process from an input device (not shown).

In the membrane position adjusting device 1D of the present embodiment, the position of the diaphragm 42 of the pressure measuring instruments 31u and 31d is estimated by moving the liquid in the blood circuit 11 with the blood pump 12, and the diaphragm 42 is estimated based on the estimation result. It can be adjusted to the normal position. In the membrane position adjusting device 1, a priming liquid which is an incompressible fluid is used for adjusting the position of the diaphragm 42. Therefore, the position of the diaphragm 42 is adjusted by the priming liquid having less expansion and contraction due to individual differences in the shapes of the pressure measuring instruments 31u and 31d, temperature, and the like. As a result, the diaphragm 42 can be moved to a position according to the amount of the priming liquid flowing into or sucking into the blood chamber 45 without being affected by individual differences in the shapes of the pressure measuring instruments 31u and 31d and the temperature. , The position accuracy of the diaphragm 42 when adjusting the position of the diaphragm 42 can be improved. That is, the position of the diaphragm 42 of the pressure measuring instruments 31u and 31d can be estimated, and the position of the diaphragm 42 can be adjusted to the normal position based on the estimation result with high position accuracy.

Further, in the membrane position adjusting device 1D, the priming liquid does not expand or contract when flowing into or sucking into the blood chamber 45 of the pressure measuring instruments 31u and 31d, so that when the same amount of gas is flowed in or sucked. The diaphragm can be moved more than that. Therefore, the diaphragm 42 can be moved to the normal position with a smaller amount of priming liquid than air, and the adjustment time when adjusting the position of the diaphragm 42 to the normal position can be shortened.

Further, in the membrane position adjusting device 1D, since the membrane position adjusting process can be executed by the blood pump 12, the position of the diaphragm 42 can be adjusted without adding a new configuration. That is, the position of the diaphragm 42 can be adjusted without increasing the number of parts. Further, since the position of the diaphragm 42 of the two pressure measuring instruments 31u and 31d can be adjusted by the membrane position adjusting device 1A, it is not necessary to adjust the membrane position in advance according to the arrangement position, such as during manufacturing. , It is possible to omit the adjustment of the film position at the time of manufacturing. Therefore, the film position adjustment work that is artificially performed can be omitted, and the manufacturing cost associated with the artificial work can be reduced. On the other hand, when the diaphragm 42 is arranged at the normal position, the adjustment work of the diaphragm 42 can be omitted, and the adjustment time can be shortened.

Further, since the membrane position adjusting device 1 estimates the position of the diaphragm 42 and sucks and supplies the priming liquid to the blood chamber 45 according to the position, the priming liquid is excessively sucked or supplied to the blood chamber 45. It can be suppressed. As a result, it is possible to prevent the diaphragm 42 from being subjected to excessive pressure and changing the characteristics of the diaphragm 42, and it is possible to prevent the measurement result after the position adjustment of the diaphragm 42 from being varied for each membrane position adjusting device 1. be able to.

In addition, the film position adjusting device 1D of the fifth embodiment has the same effect as that of the film position adjusting device 1C of the fourth embodiment.

<Other Embodiments>
In the membrane position adjusting devices 1, 1A and 1B of the first to third embodiments, three pressure measuring instruments 31u, 31d and 31m are interposed in the blood circuit 11, but the number is not necessarily three. It may be one or two, or four or more. The shape of the pressure measuring instrument 31 is not limited to that described above. The same applies to the film position adjusting devices 1C and 1D of the fourth and fifth embodiments, and the number may be one or three or more, and the shape of the pressure measuring instrument 31 is not limited to that described above.

Further, in the membrane position adjusting devices 1, 1A to 1D of the first to fifth embodiments, the limit position of the diaphragm 42 of the pressure measuring instrument 31 is such that the main body portion 42b is along the lower housing portion 41a or the upper housing portion 41b. However, it is not necessarily limited to such a position. For example, when the diaphragm 42 is formed into a shape smaller than the inner peripheral surface of the lower housing portion 41a or the upper housing portion 41b, the limit position is the position where the main body portion 42b is not further deformed. Further, the deformation of the diaphragm 42 is stopped by another member other than the lower housing portion 41a and the upper housing portion 41b, and the position where the diaphragm 42 is not deformed is the limit position of the diaphragm 42.

Further, in the membrane position adjusting devices 1, 1A and 1B of the first to third embodiments, the positions of the diaphragms 42 and 62 are detected based on the volume of the air sucked or supplied by the adjusting pump 38, but it is not always the case. It is not limited to the volume of air. For example, the flow rate of air sucked or supplied from the adjusting pump 38 may be detected, and the positions of the diaphragms 42 and 62 may be detected based on the detected air flow rate. That is, the positions of the diaphragms 42 and 62 may be detected based on the amount of gas such as the volume and flow rate of air.

Further, in the blood purification systems 2 and 2C, the membrane position adjusting devices 1, 1A, 1B and 1D estimate and adjust the positions of the diaphragms 42 and 62 after the priming, but it is not always necessary after the priming. There is no. Specifically, the estimation and adjustment of the positions of the diaphragms 42 and 62 may be performed at the same time as the priming, or may be performed during the treatment after the priming. When the membrane position adjusting devices 1, 1A and 1B of the first to third embodiments are performed during the treatment after priming, for example, the female connector portion 44 is disengaged during the treatment and the positions of the diaphragms 42 and 62 are inappropriate. In some cases. In this case, the position of the diaphragm may be adjusted after the female connector portion 44 is reconnected. If the specifications are such that the positions of the diaphragms 42 and 62 are estimated and adjusted at the same time as or immediately after the priming, it is possible to eliminate the need for the manufacturer to adjust the positions of the diaphragms 42 and 62 at the time of manufacturing.

Further, in the film position adjusting devices 1 and 1A of the first to third embodiments, the detection line 40 is formed by branching from the adjusting line 37, but the detection line 40 is formed separately from the adjusting line 37. May be good. In this case, the pressure measuring instrument 31 and the upper housing portions 41b and 61b of the drip chambers 14A and 15A are formed with attachment ports different from the connection ports 41e and 61e, and the detection line 40 is connected to these attachment ports. Will be done.

In the membrane position adjusting devices 1C and 1D of the fourth and fifth embodiments, a roller pump is adopted as the blood pump 12, but the pump is not necessarily limited to the roller pump and may be any pump that can adjust the flow rate to be sent. .. Further, the shapes of the pressure measuring instruments 31u and 31d do not necessarily have to be as described above, and the blood chamber 45 and the gas chamber 46 may be partitioned by the diaphragm 42. Further, the opening / closing mechanism does not necessarily have to be the opening / closing valves 18 and 19, and may be something like a clip whose movement can be controlled by the controller 36C. Further, an on-off valve different from the on-off valves 18 and 19 is provided between the blood pump 12 and each of the upstream and downstream pressure measuring instruments 31u and 31d, and these on-off valves are opened and closed when the position is adjusted. It may be used instead of the valves 18 and 19.

1,1A ~ 1D Membrane position adjustment device 2,2C Blood purification system 11 Blood circuit 12 Blood pump 13 Blood purification machine 14A, 15A Drip chamber 16 Priming liquid supply device 18 Upstream opening / closing valve (opening / closing mechanism)
19 Downstream opening / closing valve (opening / closing mechanism)
30 Opening / closing mechanism 31 Pressure measuring instrument 31u 1st pressure measuring instrument 31d 2nd pressure measuring instrument 31m 3rd pressure measuring instrument 33 Female connector 34 Gas amount regulator 35 Pressure sensor 35u Upstream pressure sensor (pressure detection) vessel)
35d Downstream pressure sensor (pressure detector)
36, 36C Controller 37 Adjustment line 41 Housing 41g Interior space 42 Septum 43 Air tube 45 Blood chamber (liquid chamber)
46 Gas chamber 47 Open valve 47 (Atmospheric open valve)
47u upstream open valve (atmospheric open valve)
47d Downstream open valve (atmospheric open valve)
50 Alarm 61 Housing 61a Lower housing 61b Upper housing 61f Stepped surface 61g Internal space 61h Air vent hole 62 Septum 65 Blood chamber (liquid chamber)
66 Gas chamber

Claims (6)

A blood circuit through which blood or priming liquid flows as a liquid,
A blood pump provided in the blood circuit and for sucking and sending a liquid in the blood circuit,
The blood circuit is provided on at least one of the upstream side and the downstream side of the blood pump, and the internal space of the housing is divided into a liquid chamber connected to the blood circuit by a diaphragm and a gas chamber filled with gas and sealed. With pressure measuring instruments
An opening / closing mechanism provided on the opposite side of the blood pump to the pressure measuring device in the blood circuit to open / close the blood circuit.
An atmospheric release valve that opens the gas chamber of the pressure measuring instrument to the atmosphere,
A pressure detector that outputs a signal according to the internal pressure of the gas chamber, and
A controller that detects the internal pressure of the gas chamber based on a signal from the pressure detector and controls the movement of the blood pump, the opening / closing mechanism, and the air release valve is provided.
The diaphragm of the pressure measuring instrument is deformed so as to stop at a position where the internal pressure of the gas chamber and the internal pressure of the liquid chamber are in equilibrium.
The controller operates the blood pump in a state where the opposite side of the blood pump is closed in the blood circuit by the opening / closing mechanism to suck and send a liquid, and when the detected internal pressure of the gas chamber becomes a constant pressure. The position of the diaphragm is adjusted by controlling the movements of the blood pump, the opening / closing mechanism, and the opening valve of the atmosphere so as to stop sending the liquid and open the gas chamber to the atmosphere. Adjustment device. The pressure measuring instrument is provided at least upstream of the blood pump in the blood circuit.
The pressure measuring instrument provided on the upstream side of the blood pump is an upstream pressure measuring instrument.
When adjusting the position of the diaphragm of the upstream pressure measuring instrument, the controller supplies the liquid to the liquid chamber with the opposite side of the blood pump blocked in the blood circuit by the opening / closing mechanism. The membrane position adjusting device according to claim 1, which controls the movement of the blood pump. The pressure measuring instrument is provided at least downstream of the blood pump in the blood circuit.
The pressure measuring instrument provided at least on the downstream side of the blood pump is a downstream pressure measuring instrument.
When adjusting the position of the diaphragm of the downstream pressure measuring device, the controller sucks liquid from the liquid chamber with the opposite side of the blood pump blocked in the blood circuit by the opening / closing mechanism. The membrane position adjusting device according to claim 1 or 2, which controls the movement of the blood pump. The controller according to claims 1 to 3, wherein when adjusting the position of the diaphragm, the movement of the opening / closing mechanism is controlled so as to open the blood circuit after opening the gas chamber to the atmosphere. The film position adjusting device according to any one. When adjusting the position of the diaphragm, the controller flows the liquid in the opposite direction to make the internal pressure of the gas chamber constant, and then causes the liquid to flow in the forward direction until the internal pressure of the gas chamber starts to fluctuate. The membrane position adjusting device according to any one of claims 1 to 3, wherein the movements of the blood pump and the air release valve are controlled so as to open the gas chamber to the atmosphere after flowing. The film position adjusting device according to any one of claims 1 to 5 and
A blood purifier for purifying the blood flowing through the blood circuit,
A blood purification system including a priming liquid supply device for supplying the priming liquid to the blood circuit.
The controller is a blood purification system that adjusts the position of the diaphragm after filling the blood circuit with the priming solution.

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