JP6843616B2 - アモルファステコビリマット調製 - Google Patents

アモルファステコビリマット調製 Download PDF

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Publication number
JP6843616B2
JP6843616B2 JP2016526997A JP2016526997A JP6843616B2 JP 6843616 B2 JP6843616 B2 JP 6843616B2 JP 2016526997 A JP2016526997 A JP 2016526997A JP 2016526997 A JP2016526997 A JP 2016526997A JP 6843616 B2 JP6843616 B2 JP 6843616B2
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Japan
Prior art keywords
amorphous
octahydro
isoindole
dioxo
trifluoromethyl
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JP2016526997A
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English (en)
Japanese (ja)
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JP2016527229A (ja
JP2016527229A5 (enExample
Inventor
シャンタクマール・アール・チャヴァナギマット
エヌ・ケー・ピーター・サミュエル
ジョセフ・パズ
イン・タン
デニス・イー・フルビー
Original Assignee
シガ・テクノロジーズ・インコーポレーテッド
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Publication of JP2016527229A5 publication Critical patent/JP2016527229A5/ja
Priority to JP2020195121A priority Critical patent/JP7681393B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C07D209/76—4,7-Endo-alkylene-iso-indoles with oxygen atoms in positions 1 and 3

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016526997A 2013-07-19 2014-07-11 アモルファステコビリマット調製 Active JP6843616B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020195121A JP7681393B2 (ja) 2013-07-19 2020-11-25 アモルファステコビリマット調製

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361856240P 2013-07-19 2013-07-19
US61/856,240 2013-07-19
PCT/US2014/046340 WO2015009566A1 (en) 2013-07-19 2014-07-11 Amorphous tecovirimat preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020195121A Division JP7681393B2 (ja) 2013-07-19 2020-11-25 アモルファステコビリマット調製

Publications (3)

Publication Number Publication Date
JP2016527229A JP2016527229A (ja) 2016-09-08
JP2016527229A5 JP2016527229A5 (enExample) 2017-08-24
JP6843616B2 true JP6843616B2 (ja) 2021-03-17

Family

ID=52346653

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016526997A Active JP6843616B2 (ja) 2013-07-19 2014-07-11 アモルファステコビリマット調製
JP2020195121A Active JP7681393B2 (ja) 2013-07-19 2020-11-25 アモルファステコビリマット調製
JP2023065084A Pending JP2023080234A (ja) 2013-07-19 2023-04-12 アモルファステコビリマット調製

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020195121A Active JP7681393B2 (ja) 2013-07-19 2020-11-25 アモルファステコビリマット調製
JP2023065084A Pending JP2023080234A (ja) 2013-07-19 2023-04-12 アモルファステコビリマット調製

Country Status (8)

Country Link
US (3) US9670158B2 (enExample)
EP (2) EP3763702B1 (enExample)
JP (3) JP6843616B2 (enExample)
CN (2) CN105307636A (enExample)
AU (1) AU2014290333B2 (enExample)
CA (3) CA2917199C (enExample)
IL (1) IL242331B (enExample)
WO (1) WO2015009566A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105307636A (zh) * 2013-07-19 2016-02-03 西佳技术公司 非晶形特考韦瑞制备
CN107126419B (zh) * 2016-02-26 2020-06-19 石药集团中诺药业（石家庄）有限公司 一种奥贝胆酸片剂及其制备方法
CN112955130A (zh) * 2018-10-30 2021-06-11 佩洛通治疗公司 包含取代茚满的固体分散体和药物组合物及其制备和使用方法
CN115141136B (zh) * 2021-03-31 2023-06-20 中国人民解放军军事科学院军事医学研究院 特考韦瑞药的共晶及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20011184A1 (es) 2000-03-16 2001-11-15 Pfizer Prod Inc Composiciones farmaceuticas de inhibidores de la glucogeno-fosforilasa
US6596771B2 (en) 2001-01-12 2003-07-22 Schering Corporation Drugs for treating viral infections
US6433016B1 (en) 2001-01-12 2002-08-13 Vassil Stefanov Georgiev Drugs for treating viral infections
US7687641B2 (en) 2003-06-20 2010-03-30 Siga Technologies, Inc. Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
PL1638938T3 (pl) 2003-06-20 2017-10-31 Siga Tech Inc Związki, kompozycje i sposoby do leczenia i zapobiegania infekcjom ortopokswirusami i powiązanym chorobom
WO2006110655A2 (en) * 2005-04-08 2006-10-19 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
JP2010526848A (ja) * 2007-05-11 2010-08-05 エフ．ホフマン−ラ ロシュ アーゲー 難溶性薬物用の医薬組成物
PE20170944A1 (es) * 2010-03-23 2017-07-13 Siga Tech Inc Formas polimorficas de st-246 y metodos de preparacion
RU2566716C2 (ru) * 2010-06-09 2015-10-27 Эббви Бахамаз Лтд. Твердые дисперсии, содержащие ингибиторы киназ
GB201103837D0 (en) * 2011-03-07 2011-04-20 Oxagen Ltd Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
WO2012122279A1 (en) * 2011-03-08 2012-09-13 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
KR102000312B1 (ko) * 2011-10-14 2019-07-15 어레이 바이오파마 인크. Erb2 (her2) 저해제의 고체 분산물
JP2013103899A (ja) * 2011-11-11 2013-05-30 Fuji Chem Ind Co Ltd 難溶性薬物の新規な固体分散体
CN102406617B (zh) * 2011-11-30 2013-08-28 中国人民解放军军事医学科学院生物工程研究所 一种替韦立马干混悬剂及其制备方法
CN105307636A (zh) 2013-07-19 2016-02-03 西佳技术公司 非晶形特考韦瑞制备

Also Published As

Publication number Publication date
CA3246369A1 (en) 2025-10-30
IL242331B (en) 2021-02-28
EP3763702A1 (en) 2021-01-13
US9670158B2 (en) 2017-06-06
EP3021836A4 (en) 2016-12-07
CA2917199C (en) 2021-08-31
CA2917199A1 (en) 2015-01-22
EP3021836A1 (en) 2016-05-25
WO2015009566A1 (en) 2015-01-22
JP2016527229A (ja) 2016-09-08
JP2023080234A (ja) 2023-06-08
JP2021028336A (ja) 2021-02-25
US10045963B2 (en) 2018-08-14
US20160152565A1 (en) 2016-06-02
CN105307636A (zh) 2016-02-03
AU2014290333B2 (en) 2018-11-08
US20170224661A1 (en) 2017-08-10
WO2015009566A8 (en) 2015-12-10
JP7681393B2 (ja) 2025-05-22
EP3763702B1 (en) 2023-12-13
US20180125819A1 (en) 2018-05-10
EP3021836B1 (en) 2020-10-07
AU2014290333A1 (en) 2015-12-03
CN111635353A (zh) 2020-09-08
CA3128535C (en) 2024-10-15
US9889119B2 (en) 2018-02-13
CA3128535A1 (en) 2015-01-22

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