JP6834989B2 - 幼若哺乳動物における経口寛容の誘導及び維持において使用するための寛容原性ペプチドとtfg−bとの組み合わせ - Google Patents
幼若哺乳動物における経口寛容の誘導及び維持において使用するための寛容原性ペプチドとtfg−bとの組み合わせ Download PDFInfo
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Description
配列番号1〜8の配列を有するペプチドとTGF−βとを含む組成物を離乳時の仔ラットに投与することによる効果を調査するためのin vivo試験を実施した。具体的には、組成物の投与後、食物アレルギーに対する仔マウスの防御を測定した。
仔マウスには、未処置の母マウスにより授乳させ、離乳後、以下の経口レジメンを採用した:
水又はNAN(登録商標)−HAフォーミュラ又はTGF−β強化NAN(登録商標)−HAフォーミュラ
水又はNAN(登録商標)−HAフォーミュラ又はTGF−β強化NAN(登録商標)−HAフォーミュラ
0:正常/硬便
1:柔らかく、粘り気があり、良好に形状を保っている便
2:形状が損なわれている便
3:液状の下痢を1回(one episode)
4:液状の下痢を2回以上(2 or more episodes)
結果は、マン・ホイットニーのノンパラメトリック試験を用い比較した。図1に示す。
本発明により使用するための乳児用フォーミュラの組成物の例を以下に示す。この組成物は例示目的でのみ与えられる。
Claims (16)
- 配列番号1〜5から選択された配列をそれぞれ含み5〜12アミノ酸の鎖長を有する少なくとも5つの異なるペプチドと、
TGF−βと、を含み、
前記配列番号1〜5のそれぞれが組成物中に存在する、離乳期中及び離乳期後の幼若哺乳動物における、BLGに対する経口寛容の誘導及び維持、並びに母乳の摂取を介して獲得されたその他の食物タンパク質に対する経口寛容の維持において使用するための栄養組成物。 - 配列番号1〜5から選択された配列をそれぞれ含み5〜12アミノ酸の鎖長を有する少なくとも5つの異なるペプチドと、
TGF−βと、を含み、
前記配列番号1〜5のそれぞれが組成物中に存在する、離乳中及び離乳後の幼若哺乳動物において、乳タンパク質及び新しく導入された食物タンパク質に対する、アレルギー反応の一次予防に使用するための栄養組成物。 - 配列番号1〜5から選択された配列をそれぞれ含み5〜12アミノ酸の鎖長を有する少なくとも5つの異なるペプチドと、
TGF−βと、を含み、
前記配列番号1〜5のそれぞれが組成物中に存在する、離乳中及び離乳後の幼若哺乳動物におけるアトピー性疾患の一次予防に使用するための栄養組成物。 - 加水分解率が8〜15%である乳加水分解物を含む、請求項1〜3のいずれか一項に記載の栄養組成物。
- 前記少なくとも5つのペプチド及びTGF−βに加えて、配列番号6〜8から選択された配列を含み、かつ5〜12アミノ酸の鎖長を有する少なくとも1つのペプチドを含む、請求項1〜4のいずれか一項に記載の組成物。
- 前記1つ又は複数のペプチドが乳由来のものであり、特に、β−ラクトグロブリン由来のものである、請求項1〜5のいずれか一項に記載の組成物。
- 前記1つ又は複数のペプチドが、(i)β−ラクトグロブリンを含むタンパク質性物質の加水分解から分離したペプチド画分、及び/又は(ii)合成的に調製された1つ又は複数のペプチドとして存在する、請求項1〜6のいずれか一項に記載の組成物。
- 前記TGF−βが、ウシ、ヤギ、バッファロー又はラクダの乳に由来するホエイ画分若しくはカゼイン画分の形態、又は組換TGF−βの形態である、請求項1〜7のいずれか一項に記載の組成物。
- ヒト母乳強化剤、スターターフォーミュラ、又はフォローオンフォーミュラである、請求項1〜8のいずれか一項に記載の組成物。
- 前記TGFβが、TGFβ−1及びTGFβ−2の混合物である、請求項1〜9のいずれか一項に記載の組成物。
- TGFβ−1のTGFβ−2に対する比が、2:1〜1:20の間の範囲である、請求項1〜10のいずれか一項に記載の組成物。
- TGFβ−1のTGFβ−2に対する比が、1:10〜1:20の間の範囲である、請求項1〜11のいずれか一項に記載の組成物。
- 前記幼若哺乳動物がヒトの乳児又は幼児である、請求項1〜12のいずれか一項に記載の組成物。
- 前記幼若哺乳動物が、乳、卵、(樹木になる)ナッツ類、ピーナッツ、甲殻類、小麦若しくは大豆、又は何らかのその他の食物タンパク質に摂食中に暴露されたことのある母体に由来する母乳を授乳されたことがある、請求項1〜13のいずれか一項に記載の組成物。
- 前記幼若哺乳動物に、アレルギーを発症するリスクがある、請求項1〜14のいずれか一項に記載の組成物。
- コンパニオンアニマルに投与される、請求項1〜12のいずれか一項に記載の組成物。
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