JP6818215B2 - クモ毒ペプチド由来の神経保護剤 - Google Patents

クモ毒ペプチド由来の神経保護剤 Download PDF

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JP6818215B2
JP6818215B2 JP2018502163A JP2018502163A JP6818215B2 JP 6818215 B2 JP6818215 B2 JP 6818215B2 JP 2018502163 A JP2018502163 A JP 2018502163A JP 2018502163 A JP2018502163 A JP 2018502163A JP 6818215 B2 JP6818215 B2 JP 6818215B2
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peptide
seq
hi1a
sequence
asic1a
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JP2018522555A (ja
JP2018522555A5 (enExample
Inventor
グレン フレデリック キング
グレン フレデリック キング
ラクラン ダグラス ラッシュ
ラクラン ダグラス ラッシュ
アイリーン シャサーノン
アイリーン シャサーノン
ゴンザレス サンディー ステファニー ピネダ
ゴンザレス サンディー ステファニー ピネダ
ロバート エドワード ウィドップ
ロバート エドワード ウィドップ
クラウディア アン アイルランド
クラウディア アン アイルランド
Original Assignee
ザ ユニバーシティー オブ クイーンズランド
ザ ユニバーシティー オブ クイーンズランド
モナシュ ユニバーシティー
モナシュ ユニバーシティー
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Priority claimed from AU2015902845A external-priority patent/AU2015902845A0/en
Application filed by ザ ユニバーシティー オブ クイーンズランド, ザ ユニバーシティー オブ クイーンズランド, モナシュ ユニバーシティー, モナシュ ユニバーシティー filed Critical ザ ユニバーシティー オブ クイーンズランド
Publication of JP2018522555A publication Critical patent/JP2018522555A/ja
Publication of JP2018522555A5 publication Critical patent/JP2018522555A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
JP2018502163A 2015-07-17 2016-07-18 クモ毒ペプチド由来の神経保護剤 Active JP6818215B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015902845A AU2015902845A0 (en) 2015-07-17 ASIC1a modulators inspired by spider venom peptides
AU2015902845 2015-07-17
PCT/AU2016/050633 WO2017011863A1 (en) 2015-07-17 2016-07-18 Neuroprotective agents derived from spider venom peptides

Publications (3)

Publication Number Publication Date
JP2018522555A JP2018522555A (ja) 2018-08-16
JP2018522555A5 JP2018522555A5 (enExample) 2019-08-22
JP6818215B2 true JP6818215B2 (ja) 2021-01-20

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ID=57833496

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JP2018502163A Active JP6818215B2 (ja) 2015-07-17 2016-07-18 クモ毒ペプチド由来の神経保護剤

Country Status (5)

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US (2) US10485847B2 (enExample)
EP (1) EP3325503B1 (enExample)
JP (1) JP6818215B2 (enExample)
AU (1) AU2016295423B2 (enExample)
WO (1) WO2017011863A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017011863A1 (en) 2015-07-17 2017-01-26 The University Of Queensland Neuroprotective agents derived from spider venom peptides
MX2019011917A (es) 2017-04-04 2020-01-09 Univ Baylor Toxinas mosquitocidas dirigidas.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
WO2001085931A2 (en) * 2000-05-10 2001-11-15 Centre National De La Recherche Scientifique-Cnrs- Polypeptide inhibiting a proton-gated na+ channel
WO2007030580A2 (en) * 2005-09-09 2007-03-15 Oregon Health & Science University Neuroprotectants
BRPI0605484A8 (pt) * 2006-11-21 2017-03-07 Fund Amparo Pesquisa Estado Minas Gerais Fapemig Toxina ph(alfa)1b, cdna do gene da toxina ph(alfa)1b, composições farmacêuticas contendo a toxina ph(alfa)1b, processo para sua obtenção, processo para obtenção do cdna, e produto
CN112400900A (zh) 2012-03-09 2021-02-26 韦斯塔隆公司 毒肽产生、植物中的肽表达和富含半胱氨酸的肽的组合
WO2017011863A1 (en) 2015-07-17 2017-01-26 The University Of Queensland Neuroprotective agents derived from spider venom peptides

Also Published As

Publication number Publication date
US10485847B2 (en) 2019-11-26
AU2016295423A1 (en) 2018-03-08
EP3325503A1 (en) 2018-05-30
JP2018522555A (ja) 2018-08-16
US20200061156A1 (en) 2020-02-27
EP3325503A4 (en) 2019-03-27
US10881712B2 (en) 2021-01-05
EP3325503B1 (en) 2026-06-24
AU2016295423B2 (en) 2020-09-03
US20180207235A1 (en) 2018-07-26
WO2017011863A1 (en) 2017-01-26

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