JP6807116B1 - Calcium carbonate scale remover - Google Patents
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title claims description 100
- 229910000019 calcium carbonate Inorganic materials 0.000 title claims description 51
- 239000002738 chelating agent Substances 0.000 claims abstract description 32
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 22
- 238000000502 dialysis Methods 0.000 claims abstract description 13
- 150000003863 ammonium salts Chemical group 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 11
- 238000006386 neutralization reaction Methods 0.000 abstract description 7
- 239000002351 wastewater Substances 0.000 abstract description 4
- 230000003472 neutralizing effect Effects 0.000 abstract description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 4
- 229910052791 calcium Inorganic materials 0.000 abstract 4
- 239000011575 calcium Substances 0.000 abstract 4
- 239000013522 chelant Substances 0.000 abstract 1
- 238000010586 diagram Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 18
- 238000004090 dissolution Methods 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 229920006395 saturated elastomer Polymers 0.000 description 6
- 239000010865 sewage Substances 0.000 description 5
- 230000002378 acidificating effect Effects 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 239000011550 stock solution Substances 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- AGMNQPKGRCRYQP-UHFFFAOYSA-N 2-[2-[2-[bis(carboxymethyl)amino]ethylamino]ethyl-(carboxymethyl)amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)CCNCCN(CC(O)=O)CC(O)=O AGMNQPKGRCRYQP-UHFFFAOYSA-N 0.000 description 1
- URDCARMUOSMFFI-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid Chemical compound OCCN(CC(O)=O)CCN(CC(O)=O)CC(O)=O URDCARMUOSMFFI-UHFFFAOYSA-N 0.000 description 1
- QOPUBSBYMCLLKW-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]-4-hydroxybutanoic acid Chemical compound OCCC(C(O)=O)N(CC(O)=O)CCN(CC(O)=O)CC(O)=O QOPUBSBYMCLLKW-UHFFFAOYSA-N 0.000 description 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000009418 renovation Methods 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Abstract
【課題】ｐＨ中和処理装置を設置せずとも、ｐＨ排水基準を満たし、酸剤と同程度の効果があるカルシウムスケール除去剤を提供する。【解決手段】人工透析装置の透析液ラインで発生するカルシウムスケールを除去するカルシウムスケール除去剤であって、使用希釈液のｐＨが５．０〜９．０からなる液性で、主成分がキレート剤からなる。そして、このキレート剤は、ＥＤＴＡのアンモニウム塩である。これにより、ｐＨ中和処理装置を設置せずとも、ｐＨ排水基準を満たし、酸剤と同程度の効果があるカルシウムスケール除去剤を提供することができる。【選択図】なしPROBLEM TO BE SOLVED: To provide a calcium scale removing agent which satisfies a pH wastewater standard and has the same effect as an acid agent without installing a pH neutralizing treatment device. SOLUTION: This is a calcium scale remover for removing calcium scale generated in a dialysate line of an artificial dialysis machine, which has a pH of a diluent used of 5.0 to 9.0 and whose main component is a chelate. Consists of agents. And this chelating agent is an ammonium salt of EDTA. This makes it possible to provide a calcium scale remover that satisfies the pH wastewater standard and has the same effect as an acid agent without installing a pH neutralization treatment device. [Selection diagram] None
Description
本発明は、人工透析装置の透析液ラインで発生する炭酸カルシウムスケールを除去する炭酸カルシウムスケール除去剤に関する。 The present invention relates to a calcium carbonate scale remover that removes calcium carbonate scale generated in a dialysate line of an artificial dialysis machine.
従来、人工透析装置の透析液ラインで発生する炭酸カルシウムスケールを除去する炭酸カルシウムスケール除去剤として、酢酸、過酢酸、酢酸代替品（クエン酸、リンゴ酸、スルファミン酸など有機酸配合品）が使用されている。これら酸剤は、炭酸カルシウムスケールの溶解除去に優れているものの、使用後の酸性排液は中和処理されなければならず、ｐＨ中和処理装置の導入が必要となっている（例えば、特許文献１参照）。 Conventionally, acetic acid, peracetic acid, and acetic acid substitutes (organic acid blended products such as citric acid, malic acid, and sulfamic acid) have been used as calcium carbonate scale removers for removing calcium carbonate scale generated in the dialysate line of artificial dialysis machines. Has been done. Although these antacids are excellent in dissolving and removing calcium carbonate scale, the acidic effluent after use must be neutralized, and it is necessary to introduce a pH neutralizing treatment device (for example, patent). Reference 1).
しかしながら、上記のようなｐＨ中和処理装置は、大型であるため、設置に多大な時間と費用を要するという問題がある。特に、貸ビルに診療所を開院している医療施設では、設置にあたって、外壁工事を伴う増改築等に各種許可が必要となることや、設置する屋外スペースの確保が難しいことから、容易にｐＨ中和処理装置を設置することができず、もって、中和処理していない未中和の酸性排液を、下水へ排液するような医療施設も存在しているという問題がある。しかして、このように、中和処理していない未中和の酸性排液を下水へ排液することにより、公共のコンクリート製下水母管が腐食損傷され、道路の陥没が発生するという事例が発生し、社会問題となっている。 However, since the pH neutralization treatment device as described above is large in size, there is a problem that a large amount of time and cost are required for installation. In particular, in medical facilities that have clinics open in rental buildings, various permits are required for extension and renovation that involves exterior wall construction, and it is difficult to secure an outdoor space to install, so pH is easy. There is a problem that it is not possible to install a neutralization treatment device, and therefore there are medical facilities that drain unneutralized acidic effluent into sewage. In this way, there are cases where unneutralized acidic drainage that has not been neutralized is drained into sewage, causing corrosion damage to public concrete sewage mother pipes and causing road depression. It has occurred and has become a social problem.
そこで、上記のような問題を解決すべく、酸を除いて炭酸カルシウムスケールを溶解除去する術として、キレート剤を使用することが考えられる。 Therefore, in order to solve the above problems, it is conceivable to use a chelating agent as a technique for dissolving and removing the calcium carbonate scale by removing the acid.
しかしながら、一般的に、キレート剤による炭酸カルシウムスケールの除去は、酸を用いた除去に比べ効果が弱く、実用に耐え得るものではないという問題があった。 However, in general, the removal of calcium carbonate scale by a chelating agent has a weaker effect than the removal using an acid, and has a problem that it cannot be put into practical use.
そこで本発明は、上記問題に鑑み、ｐＨ中和処理装置を設置せずとも、ｐＨ排水基準を満たし、酸剤と同程度の効果がある炭酸カルシウムスケール除去剤を提供することを目的としている。 Therefore, in view of the above problems, it is an object of the present invention to provide a calcium carbonate scale remover that satisfies the pH wastewater standard and has the same effect as an acid agent without installing a pH neutralization treatment device.
上記本発明の目的は、以下の手段によって達成される。 The above object of the present invention is achieved by the following means.
すなわち、請求項１に係る炭酸カルシウムスケール除去剤は、人工透析装置の透析液ラインで発生する炭酸カルシウムスケールを除去する炭酸カルシウムスケール除去剤であって、使用希釈液のｐＨが５．０又は７．０からなる液性で、主成分がキレート剤からなり、
前記キレート剤は、ＥＤＴＡのアンモニウム塩であって、前記炭酸カルシウムスケール除去剤に対する当該キレート剤の純分濃度が前記使用希釈液において０．４重量％であることを特徴としている。
That is, the calcium carbonate scale remover according to claim 1 is a calcium carbonate scale remover that removes the calcium carbonate scale generated in the dialysate line of the artificial dialysis machine, and the pH of the diluted solution used is 5.0 or 7. It is a liquid consisting of .0 , and the main component is a chelating agent.
The chelating agent is an ammonium salt of EDTA, and is characterized in that the pure concentration of the chelating agent with respect to the calcium carbonate scale remover is 0.4% by weight in the diluted solution used .
請求項１の発明に係る炭酸カルシウムスケール除去剤は、人工透析装置の透析液ラインで発生する炭酸カルシウムスケールを除去する炭酸カルシウムスケール除去剤であって、使用希釈液のｐＨが５．０又は７．０からなる液性で、主成分がキレート剤からなる。そして、キレート剤は、ＥＤＴＡのアンモニウム塩であって、炭酸カルシウムスケール除去剤に対する当該キレート剤の純分濃度が使用希釈液において０．４重量％であるから、低濃度で使用することができ、且つ、炭酸カルシウムの溶解速度に優れている。これにより、優れた炭酸カルシウム溶解性を発揮し、原液の高濃度化が可能となり、もって、ｐＨ中和処理装置を設置せずとも、ｐＨ排水基準を満たし、且つ、酸剤の効果と同様の効果をより奏することができる。 The calcium carbonate scale remover according to the invention of claim 1 is a calcium carbonate scale remover that removes the calcium carbonate scale generated in the dialysate line of the artificial dialysis machine, and the pH of the diluted solution used is 5.0 or 7. It is a liquid consisting of 0.0 and the main component is a chelating agent. The chelating agent is an ammonium salt of EDTA, and since the pure concentration of the chelating agent with respect to the calcium carbonate scale remover is 0.4% by weight in the diluted solution used, it can be used at a low concentration. Moreover, it is excellent in the dissolution rate of calcium carbonate. As a result, excellent calcium carbonate solubility is exhibited, and the concentration of the undiluted solution can be increased. Therefore, even if a pH neutralization treatment device is not installed, the pH wastewater standard is satisfied and the effect is the same as that of the acid agent. The effect can be more effective.
本発明に係る炭酸カルシウムスケール除去剤は、人工透析装置の透析液ラインで発生する炭酸カルシウムスケールを除去する際に使用され、ｐＨ５．０〜９．０からなる希釈液（実使用液）で、主成分がキレート剤からなるものである。しかして、このような炭酸カルシウムスケール除去剤を用いることで、酸性排液を中和するｐＨ中和処理装置を用いずとも、ｐＨ排水基準を満たす排液を下水へ排液することができることとなる。 The calcium carbonate scale remover according to the present invention is used for removing the calcium carbonate scale generated in the dialysate line of the artificial dialysis machine, and is a diluted solution (actual solution) having a pH of 5.0 to 9.0. The main component is a chelating agent. Therefore, by using such a calcium carbonate scale remover, it is possible to drain the drainage satisfying the pH drainage standard into the sewage without using a pH neutralization treatment device for neutralizing the acidic drainage. Become.
すなわち、現在の法令で、下水への排水基準が、ｐＨ５．０〜９．０であることから、本発明に係る炭酸カルシウムスケール除去剤は、その基準を満たすために、ｐＨ５．０〜９．０からなる希釈液となっている。また、この炭酸カルシウムスケール除去剤の希釈使用倍率は、１００倍〜２００倍を濃度範囲としている。これにより、既存の人工透析装置の洗浄液希釈倍率に変更を加えることなく使用することができる。すなわち、人工透析装置の透析液ラインで発生する炭酸カルシウムスケールを除去する炭酸カルシウムスケール除去剤としての酸剤は、一般的に、１００倍〜２００倍の濃度に希釈して使用されている。そのため、本発明に係る炭酸カルシウムスケール除去剤を１００倍〜２００倍の濃度に希釈して使用するようにすれば、既存の人工透析装置の洗浄液希釈倍率に変更を加えることなく使用することが可能となる。 That is, since the standard for drainage to sewage is pH 5.0 to 9.0 under the current laws and regulations, the calcium carbonate scale remover according to the present invention has a pH of 5.0 to 9. It is a diluted solution consisting of 0. The dilution ratio of this calcium carbonate scale remover is 100 to 200 times in the concentration range. As a result, it can be used without changing the washing solution dilution ratio of the existing artificial dialysis machine. That is, an acid agent as a calcium carbonate scale remover for removing calcium carbonate scale generated in a dialysate line of an artificial dialysis machine is generally used after being diluted to a concentration of 100 to 200 times. Therefore, if the calcium carbonate scale remover according to the present invention is diluted to a concentration of 100 to 200 times and used, it can be used without changing the washing solution dilution ratio of the existing artificial dialysis machine. It becomes.
一方、キレート剤としては、ＥＤＴＡ（エチレンジアミン四酢酸）、ＮＴＡ（ニトリロ三酢酸）、ＤＴＰＡ（ジエチレントリアミン四酢酸）、ＨＥＤＴＡ（ヒドロキシエチルエチレンジアミン三酢酸）、及びこれらのナトリウム塩、カリウム塩、アンモニウム塩などが挙げられる。しかしながら、キレート剤の種類によっては、原液の高濃度化が難しく、希釈倍率をさらに低くし濃く使用しなければ十分な効果が得られにくい。そのため、キレート剤としては、ＥＤＴＡ（エチレンジアミン四酢酸）のアンモニウム塩が望ましい。キレート剤として、ＥＤＴＡ（エチレンジアミン四酢酸）のアンモニウム塩を使用することにより、優れた炭酸カルシウム溶解性を発揮し、原液の高濃度化が可能なため、酸剤の効果と同様の効果をより奏することができるためである。 On the other hand, examples of the chelating agent include EDTA (ethylenediaminetetraacetic acid), NTA (nitrilotriacetic acid), DTPA (diethylenetriaminetetraacetic acid), HEDTA (hydroxyethylethylenediaminetetraacetic acid), and sodium salts, potassium salts, ammonium salts and the like thereof. Can be mentioned. However, depending on the type of chelating agent, it is difficult to increase the concentration of the stock solution, and it is difficult to obtain a sufficient effect unless the dilution ratio is further lowered and used in a concentrated manner. Therefore, as the chelating agent, an ammonium salt of EDTA (ethylenediaminetetraacetic acid) is desirable. By using an ammonium salt of EDTA (ethylenediaminetetraacetic acid) as a chelating agent, excellent calcium carbonate solubility is exhibited and the concentration of the stock solution can be increased, so that the same effect as that of the acid agent is exhibited. Because it can be done.
しかして、このような炭酸カルシウムスケール除去剤を、人工透析装置の透析液ラインで発生する炭酸カルシウムスケールを除去する際に使用するようにすれば、ｐＨ中和処理装置を設置せずとも、ｐＨ排水基準を満たすことができ、さらに、酸剤と同程度の効果を奏することができる。 Therefore, if such a calcium carbonate scale remover is used to remove the calcium carbonate scale generated in the dialysate line of the artificial dialysis machine, the pH can be adjusted without installing a pH neutralization treatment device. It can meet the effluent standard and can have the same effect as the acid agent.
以下に、本発明を実施例によって具体的に説明する。 Hereinafter, the present invention will be specifically described with reference to Examples.
人工透析装置の透析液ラインで発生する炭酸カルシウムスケールを除去する際に使用される炭酸カルシウムスケール除去剤の検討に当たり、各キレート剤による炭酸カルシウムの溶解量と溶解速度について評価を行った。各種キレート剤は、キレート剤骨格種毎に塩の種類およびｐＨによって評価を行った。さらに、現状、人工透析装置の透析液ラインで発生する炭酸カルシウムスケールを除去する際に使用されている酸剤についても評価を行い、比較検討を行った。 In examining the calcium carbonate scale remover used to remove the calcium carbonate scale generated in the dialysate line of the artificial dialysis machine, the dissolution amount and dissolution rate of calcium carbonate by each chelating agent were evaluated. Various chelating agents were evaluated according to the type of salt and pH for each chelating agent skeleton species. Furthermore, the acid agents currently used to remove the calcium carbonate scale generated in the dialysate line of the artificial dialysis machine were also evaluated and compared.
＜試験試料＞
試験試料として使用した各種キレート剤は、表１に示す通りである。なお、各種キレート剤の調整液としては、各骨格種となる有機酸及びその塩種の混合により、純分濃度とｐＨを調整した。
<Test sample>
The various chelating agents used as the test samples are as shown in Table 1. As the adjusting solution for various chelating agents, the pure content concentration and pH were adjusted by mixing the organic acid as each skeletal species and the salt species thereof.
また、試験試料として使用した酸剤は、表２に示す通りである。なお、炭酸カルシウムは、富士フィルム和光純薬社製の特級試薬を用いた。 The acid agents used as the test samples are as shown in Table 2. As calcium carbonate, a special grade reagent manufactured by Fuji Film Wako Pure Chemical Industries, Ltd. was used.
＜試験方法−炭酸カルシウム溶解量＞
表１に示す各キレート剤を０．４重量％となるように希釈調製し、調製液１Ｌについてマグネチックスターラーで攪拌しながら炭酸カルシウムを繰り返し添加することで飽和溶解量と溶解速度を評した。また、炭酸カルシウムの添加は０．１ｇずつ行い、添加した試薬が溶解したことを確認してから順次添加を繰り返した。そして、溶け切らなくなる直前の添加量を飽和溶解量とした。なお、表２に示す各酸剤については、０．２重量％、又は、０．３重量％となるように希釈調整し、上記と同様の試験を行った。
<Test method-Calcium carbonate dissolved amount>
Each chelating agent shown in Table 1 was diluted and prepared so as to be 0.4% by weight, and calcium carbonate was repeatedly added to 1 L of the prepared solution while stirring with a magnetic stirrer to evaluate the saturated dissolution amount and the dissolution rate. In addition, calcium carbonate was added in an amount of 0.1 g each, and after confirming that the added reagent was dissolved, the addition was repeated in sequence. Then, the amount added immediately before the solution was completely dissolved was defined as the saturated dissolved amount. Each acid agent shown in Table 2 was diluted and adjusted to 0.2% by weight or 0.3% by weight, and the same test as above was performed.
＜試験方法−炭酸カルシウム溶解速度＞
各キレート剤、並びに、各酸剤について、それぞれ飽和溶解量の５０％を溶解した状態から添加した炭酸カルシウム０．１ｇを溶解するときに要する攪拌時間により評価を行った。なお、評価基準としては、Ａ：３分未満、Ｂ：３分〜５分、Ｃ：５分〜１０分、Ｄ：１０分以上として評価を行った。
<Test method-Calcium carbonate dissolution rate>
Each chelating agent and each acid agent were evaluated by the stirring time required to dissolve 0.1 g of calcium carbonate added from the state in which 50% of the saturated dissolved amount was dissolved. The evaluation criteria were A: less than 3 minutes, B: 3 to 5 minutes, C: 5 to 10 minutes, and D: 10 minutes or more.
＜試験方法−飽和溶解濃度＞
各キレート剤、並びに、各酸剤を水に溶解し、飽和溶解濃度を確認した。各キレート剤の飽和溶解濃度は、各キレート剤骨格種となる有機酸及びその塩種の混合物を対象として試験を行った。混合割合については、合計純分濃度０．４重量％時のＰＨが、それぞれ、５．０、７．０、９．０となる時の割合を保持した。
<Test method-saturated solution concentration>
Each chelating agent and each acid agent were dissolved in water, and the saturated dissolution concentration was confirmed. The saturated dissolution concentration of each chelating agent was tested for a mixture of an organic acid and a salt species thereof, which are the skeleton species of each chelating agent. Regarding the mixing ratio, the ratios when the pH at a total net concentration of 0.4% by weight was 5.0, 7.0, and 9.0, respectively, were maintained.
＜試験結果＞
上記の試験方法にて行った試験結果を表３に示す。
<Test result>
Table 3 shows the test results performed by the above test method.
なお、表３に示すｐＨ７．０のＥＤＴＡ（ＮＨ４）、ｐＨ９．０のＥＤＴＡ（ＮＨ４）の飽和溶解濃度については、試験に使用する原料濃度によって記載の濃度が試験可能な上限となったことから、「＞６５」、「＞６３」のような表現をしている。 Incidentally, pH 7.0 of EDTA (NH 4) shown in Table 3, the saturation concentration of dissolved pH9.0 of EDTA (NH 4), the concentration of the described by the raw material concentration used in the test was a testable limit Therefore, expressions such as ">65" and ">63" are used.
表３に示す試験結果によれば、各キレート剤による０．４％濃度１Ｌに対する炭酸カルシウム溶解量は、ｐＨ５．０のＥＤＴＡ（ＮＨ４）が最も多く１．６ｇであり、次いで、ｐＨ７．０及びｐＨ９．０のＥＤＴＡ（ＮＨ４）、ｐＨ ５．０のＮＴＡ（Ｎａ）が多く、１．４ｇであった。 According to the test results shown in Table 3, the amount of calcium carbonate dissolved in 0.4% concentration 1 L by each chelating agent was 1.6 g for EDTA (NH 4 ) having a pH of 5.0, followed by pH 7.0. And EDTA (NH 4 ) with pH 9.0 and NTA (Na) with pH 5.0 were abundant and weighed 1.4 g.
また、溶解速度については、ｐＨ ５．０のＥＤＴＡ（Ｎａ）、ｐＨ５．０のＥＤＴＡ（ＮＨ４）が速く優れていた。この速度は、酸剤３種に並ぶ速度（３分未満の溶解）であった。 Regarding the dissolution rate, EDTA (Na) having a pH of 5.0 and EDTA (NH 4 ) having a pH of 5.0 were fast and excellent. This rate was comparable to that of the three acid agents (dissolution in less than 3 minutes).
さらに、キレート剤飽和溶解濃度については、各ｐＨのＥＤＴＡ（ＮＨ４）が高く優れていた。 Further, regarding the saturated dissolution concentration of the chelating agent, EDTA (NH 4 ) at each pH was high and excellent.
以上のことから、ｐＨ５．０〜９．０からなる液性で、主成分がキレート剤からなる炭酸カルシウムスケール除去剤であれば、酸剤と同程度の効果を奏することが分かった。 From the above, it was found that a calcium carbonate scale remover having a pH of 5.0 to 9.0 and having a main component of a chelating agent exerts the same effect as an acid agent.
特に、低濃度で使用でき、且つ、炭酸カルシウムの溶解速度に優れるキレート剤としては、ｐＨ５．０のＥＤＴＡ（ＮＨ４）、ｐＨ７．０のＥＤＴＡ（ＮＨ４）であることが分かった。すなわち、ｐＨ５．０のＥＤＴＡ（ＮＨ４）の高濃度溶液（４０重量％）を原液とした場合、その１００倍希釈液（ｗ／ｗ）の純分濃度は０．４重量％となり、この溶液の炭酸カルシウム量は１Ｌ当たり１．６ｇである。これは、各酸剤の炭酸カルシウム溶解量および溶解速度に並ぶものである。また、ｐＨ７．０のＥＤＴＡ（ＮＨ４）の高濃度溶液（５０重量％）を原液とした場合、その１００倍希釈液（ｗ／ｗ）の純分濃度は０．５重量％となり、期待される炭酸カルシウム量は１Ｌ当たり１．７５ｇと想定される。この場合、各酸剤の炭酸カルシウム溶解量を超え、溶解速度は酸剤に次ぐものである。 In particular, it was found that EDTA (NH 4 ) having a pH of 5.0 and EDTA (NH 4 ) having a pH of 7.0 were used as chelating agents that could be used at a low concentration and had an excellent dissolution rate of calcium carbonate. That is, when a high concentration solution (40% by weight) of EDTA (NH 4 ) having a pH of 5.0 is used as a stock solution, the pure content concentration of the 100-fold diluted solution (w / w) is 0.4% by weight, and this solution. The amount of calcium carbonate in 1 L is 1.6 g. This is in line with the amount and rate of calcium carbonate dissolved in each acid agent. Further, when a high concentration solution (50% by weight) of EDTA (NH 4 ) having a pH of 7.0 is used as a stock solution, the pure content concentration of the 100-fold diluted solution (w / w) is expected to be 0.5% by weight. The amount of calcium carbonate is estimated to be 1.75 g per liter. In this case, the amount of calcium carbonate dissolved in each acid agent is exceeded, and the dissolution rate is second only to that of the acid agent.
以上のことから、キレート剤として、特に、ＥＤＴＡのアンモニウム塩を使用することにより、酸剤の効果と同様の効果をより奏することが分かった。
From the above, it was found that the use of the ammonium salt of EDTA as the chelating agent exerts the same effect as that of the acid agent.
Claims (1)
使用希釈液のｐＨが５．０又は７．０からなる液性で、主成分がキレート剤からなり、
前記キレート剤は、ＥＤＴＡのアンモニウム塩であって、前記炭酸カルシウムスケール除去剤に対する当該キレート剤の純分濃度が前記使用希釈液において０．４重量％である炭酸カルシウムスケール除去剤。 A calcium carbonate scale remover that removes calcium carbonate scale generated in the dialysate line of an artificial dialysis machine.
The diluted solution used is liquid with a pH of 5.0 or 7.0 , and the main component is a chelating agent.
The chelating agent is an ammonium salt of EDTA, and the calcium carbonate scale removing agent has a net concentration of the chelating agent with respect to the calcium carbonate scale removing agent of 0.4% by weight in the diluted solution used.
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