JP6802153B2 - 免疫スコアを計算するためのシステム及び方法 - Google Patents

免疫スコアを計算するためのシステム及び方法 Download PDF

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JP6802153B2
JP6802153B2 JP2017512786A JP2017512786A JP6802153B2 JP 6802153 B2 JP6802153 B2 JP 6802153B2 JP 2017512786 A JP2017512786 A JP 2017512786A JP 2017512786 A JP2017512786 A JP 2017512786A JP 6802153 B2 JP6802153 B2 JP 6802153B2
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JP2017536801A (ja
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マイケル バーンズ，
マイケル バーンズ，
ティン チェン，
ティン チェン，
クリストフ シェドゥーテル，
クリストフ シェドゥーテル，
アリサ タッブズ，
アリサ タッブズ，
パオロ エー． アシエルト，
パオロ エー． アシエルト，
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ヴェンタナ メディカル システムズ， インク．
ヴェンタナ メディカル システムズ， インク．
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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/11—Region-based segmentation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/693—Acquisition
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30088—Skin; Dermal
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30096—Tumor; Lesion
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30242—Counting objects in image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00—Indexing scheme relating to image or video recognition or understanding
    • G06V2201/03—Recognition of patterns in medical or anatomical images

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  • Biomedical Technology (AREA)
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Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014031735A1 (en) * 2012-08-21 2014-02-27 Cambridge Research & Instrumentation, Inc. Visualization and measurement of cell compartments
AU2014331153A1 (en) * 2013-10-01 2016-02-25 Ventana Medical Systems, Inc. Line-based image registration and cross-image annotation devices, systems and methods
JP6588444B2 (ja) * 2014-01-28 2019-10-09 ベンタナ メディカル システムズ， インコーポレイテッド 全スライド組織セグメント化のための適応分類
JP2017099616A (ja) * 2015-12-01 2017-06-08 ソニー株式会社 手術用制御装置、手術用制御方法、およびプログラム、並びに手術システム
US9990713B2 (en) 2016-06-09 2018-06-05 Definiens Ag Detecting and visualizing correlations between measured correlation values and correlation reference values of a pathway
US10572996B2 (en) * 2016-06-28 2020-02-25 Contextvision Ab Method and system for detecting pathological anomalies in a digital pathology image and method for annotating a tissue slide
JP7356904B2 (ja) * 2016-10-27 2023-10-05 コーニンクレッカ フィリップス エヌ ヴェ １つ又は複数の組織サンプルにおける細胞組成情報を決定する装置
US11222194B2 (en) * 2016-12-30 2022-01-11 Ventana Medical Systems, Inc. Automated system and method for creating and executing a scoring guide to assist in the analysis of tissue specimen
US11023111B2 (en) 2017-11-28 2021-06-01 Micron Technology, Inc. System, apparatus, and related method for generating a geospatial interactive composite web-based image map
CN112585696B (zh) * 2018-08-30 2024-12-27 应用材料公司 用于自动肿瘤检测和分类的系统
US12031988B2 (en) * 2018-10-23 2024-07-09 Hoffmann-La Roche, Inc. Distance-based tissue state determination
CN109493325B (zh) * 2018-10-23 2021-02-26 清华大学 基于ct影像的肿瘤异质性分析系统
US10290101B1 (en) * 2018-12-07 2019-05-14 Sonavista, Inc. Heat map based medical image diagnostic mechanism
WO2020168284A1 (en) * 2019-02-15 2020-08-20 The Regents Of The University Of California Systems and methods for digital pathology
US10957043B2 (en) * 2019-02-28 2021-03-23 Endosoftllc AI systems for detecting and sizing lesions
WO2020190851A1 (en) * 2019-03-15 2020-09-24 Splntellx, Inc. An explainable ai (xai) platform for computational pathology
WO2020205245A1 (en) * 2019-03-29 2020-10-08 Tornier, Inc. Closed surface fitting for segmentation of orthopedic medical image data
US11276172B2 (en) * 2019-05-03 2022-03-15 Huron Technologies International Inc. Image diagnostic system, and methods of operating thereof
CN114761797A (zh) * 2019-10-04 2022-07-15 塞尔普利有限责任公司 高内涵分析法
WO2021076623A1 (en) * 2019-10-14 2021-04-22 University Of Southern California Systems, methods and assays for outlier clustering unsupervised learning automated report (ocular)
US11977723B2 (en) * 2019-12-17 2024-05-07 Palantir Technologies Inc. Image tiling and distributive modification
US11908130B2 (en) * 2020-01-03 2024-02-20 Protein Metrics Llc Apparatuses and methods for digital pathology
CN111242242B (zh) * 2020-02-27 2022-04-12 武汉大学 一种基于置信度选择的宫颈组织病理全玻片图像自动分类方法
WO2021225421A1 (ko) 2020-05-08 2021-11-11 주식회사 루닛 면역 항암제에 대한 반응을 예측하는 방법 및 시스템
JP7731556B2 (ja) * 2020-05-08 2025-09-01 ルニット インコーポレイテッド 病理スライドイメージに対する免疫表現型と関連付けられた情報を提供する方法及び装置
CA3188627A1 (en) * 2020-07-27 2022-02-03 Agilent Technologies, Inc. Annotation data collection using gaze-based tracking
CN111899252B (zh) 2020-08-06 2023-10-27 腾讯科技（深圳）有限公司 基于人工智能的病理图像处理方法和装置
WO2022073034A1 (en) * 2020-10-02 2022-04-07 Trimetis Life Sciences Llc Identifying morphologic, histopathologic, and pathologic features with a neural network
US11798165B2 (en) * 2020-10-28 2023-10-24 Sony Group Corporation Tumor detection and segmentation for DPI AI platform routes
CN112330624B (zh) * 2020-11-02 2025-06-06 腾讯科技（深圳）有限公司 医学图像处理方法和装置
US11321843B1 (en) * 2020-12-29 2022-05-03 Rewire Neuro, Inc. Adaptive machine learning system for image based biological sample constituent analysis
WO2022201691A1 (ja) * 2021-03-23 2022-09-29 コニカミノルタ株式会社 画像診断方法、画像診断装置および画像診断プログラム
JP2022152980A (ja) * 2021-03-29 2022-10-12 ソニーグループ株式会社 医療用画像解析装置、医療用画像解析方法及び医療用画像解析システム
CN113469939B (zh) * 2021-05-26 2022-05-03 透彻影像(北京)科技有限公司 一种基于特性曲线的her-2免疫组化自动判读系统
CN115700738B (zh) * 2021-07-21 2025-09-09 台达电子工业股份有限公司 用于检体玻片的刮取指引系统及其方法
WO2023008526A1 (ja) * 2021-07-29 2023-02-02 株式会社島津製作所 細胞画像解析方法
WO2023146733A1 (en) * 2022-01-31 2023-08-03 Bio-Rad Laboratories, Inc. Computer vision for real-time segmentation of fluorescent biological images
JP2023128033A (ja) * 2022-03-02 2023-09-14 株式会社Ｓｃｒｅｅｎホールディングス 疾患評価支援方法および疾患評価支援装置
JP7225458B1 (ja) 2022-05-10 2023-02-20 株式会社エクサウィザーズ 情報処理方法、コンピュータプログラム及び情報処理装置
CN115063796B (zh) * 2022-08-18 2022-11-15 珠海横琴圣澳云智科技有限公司 基于信号点内容约束的细胞分类方法和装置
WO2024049498A1 (en) * 2022-09-02 2024-03-07 Aixmed, Inc. Method and system to obtain sufficient cytology image in cytopathology
CN116758532B (zh) * 2023-05-06 2025-11-07 西安工业大学 基于强度像补偿的点云目标识别方法
CN116646088B (zh) * 2023-07-27 2023-12-01 广东省人民医院 一种预测方法、装置、设备及介质
CN117408657B (zh) * 2023-10-27 2024-05-17 杭州静嘉科技有限公司 一种基于人工智能的人力资源服务系统
CN119833138B (zh) * 2024-12-23 2025-11-07 广东省人民医院 一种基于细胞像素密度的肝细胞癌预后评估方法及系统

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4599191B2 (ja) * 2005-03-01 2010-12-15 国立大学法人神戸大学 画像診断処理装置および画像診断処理プログラム
DE602007009395D1 (de) * 2006-06-15 2010-11-04 Nat Univ Corp Tokyo Med & Dent Verfahren, vorrichtung und programm zur bewertung der immunität sowie datenaufzeichnungsmedium mit darin gespeichertem immunitätsbewertungsprogramm
US8244021B2 (en) 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
US8194965B2 (en) * 2007-11-19 2012-06-05 Parascript, Llc Method and system of providing a probability distribution to aid the detection of tumors in mammogram images
JP5269637B2 (ja) * 2009-02-13 2013-08-21 オリンパス株式会社 画像処理装置および画像処理プログラム
CA3010836C (en) * 2010-07-30 2020-09-08 Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions
JP5559642B2 (ja) * 2010-08-30 2014-07-23 富士フイルム株式会社 手術支援装置、手術支援方法および手術支援プログラム
US9159129B2 (en) * 2011-07-12 2015-10-13 Definiens Ag Generating image-based diagnostic tests by optimizing image analysis and data mining of co-registered images
US20130203614A1 (en) 2012-02-08 2013-08-08 Jerome Galon Methods for predicting the survival time of a patient suffering from a solid cancer
KR20140145141A (ko) * 2012-03-30 2014-12-22 클래리언트 다이아그노스틱 서비시즈, 인크. 생물학적 샘플의 영상 생성 방법
BR112014031143B8 (pt) * 2012-06-14 2022-11-22 Univ Paris Descartes Método para quantificar células imunes em tecidos tumorais e suas aplicações
JP2014092510A (ja) * 2012-11-06 2014-05-19 Toshiba Corp 医用画像処理装置および医用画像処理プログラム
EP3005293B1 (en) 2013-06-03 2018-10-03 Ventana Medical Systems, Inc. Image adaptive physiologically plausible color separation
JP6588444B2 (ja) 2014-01-28 2019-10-09 ベンタナ メディカル システムズ， インコーポレイテッド 全スライド組織セグメント化のための適応分類

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JP2017536801A (ja) 2017-12-14
EP3195191B1 (en) 2020-10-21
JP7241723B2 (ja) 2023-03-17
AU2015310886A1 (en) 2017-02-02
CA2955156C (en) 2024-04-30
EP3195191A2 (en) 2017-07-26
WO2016034655A2 (en) 2016-03-10
WO2016034655A3 (en) 2016-06-02
JP2021006037A (ja) 2021-01-21
EP3839812A2 (en) 2021-06-23
US20170270346A1 (en) 2017-09-21
CA2955156A1 (en) 2016-03-10
US10127433B2 (en) 2018-11-13
EP3839812A3 (en) 2021-09-01

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