JP6802153B2 - 免疫スコアを計算するためのシステム及び方法 - Google Patents

免疫スコアを計算するためのシステム及び方法 Download PDF

Info

Publication number
JP6802153B2
JP6802153B2 JP2017512786A JP2017512786A JP6802153B2 JP 6802153 B2 JP6802153 B2 JP 6802153B2 JP 2017512786 A JP2017512786 A JP 2017512786A JP 2017512786 A JP2017512786 A JP 2017512786A JP 6802153 B2 JP6802153 B2 JP 6802153B2
Authority
JP
Japan
Prior art keywords
tumor
region
image
marker
images
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017512786A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017536801A (ja
JP2017536801A5 (OSRAM
Inventor
マイケル バーンズ,
マイケル バーンズ,
ティン チェン,
ティン チェン,
クリストフ シェドゥーテル,
クリストフ シェドゥーテル,
アリサ タッブズ,
アリサ タッブズ,
パオロ エー. アシエルト,
パオロ エー. アシエルト,
Original Assignee
ヴェンタナ メディカル システムズ, インク.
ヴェンタナ メディカル システムズ, インク.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ヴェンタナ メディカル システムズ, インク., ヴェンタナ メディカル システムズ, インク. filed Critical ヴェンタナ メディカル システムズ, インク.
Publication of JP2017536801A publication Critical patent/JP2017536801A/ja
Publication of JP2017536801A5 publication Critical patent/JP2017536801A5/ja
Application granted granted Critical
Publication of JP6802153B2 publication Critical patent/JP6802153B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/10Segmentation; Edge detection
    • G06T7/11Region-based segmentation
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/693Acquisition
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695Preprocessing, e.g. image segmentation
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698Matching; Classification
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30024Cell structures in vitro; Tissue sections in vitro
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30088Skin; Dermal
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30096Tumor; Lesion
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30242Counting objects in image
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00Indexing scheme relating to image or video recognition or understanding
    • G06V2201/03Recognition of patterns in medical or anatomical images

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Multimedia (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Image Analysis (AREA)
JP2017512786A 2014-09-03 2015-09-03 免疫スコアを計算するためのシステム及び方法 Active JP6802153B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462045484P 2014-09-03 2014-09-03
US62/045,484 2014-09-03
PCT/EP2015/070100 WO2016034655A2 (en) 2014-09-03 2015-09-03 Systems and methods for generating fields of view

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020144563A Division JP7241723B2 (ja) 2014-09-03 2020-08-28 免疫スコアを計算するためのシステム及び方法

Publications (3)

Publication Number Publication Date
JP2017536801A JP2017536801A (ja) 2017-12-14
JP2017536801A5 JP2017536801A5 (OSRAM) 2018-10-11
JP6802153B2 true JP6802153B2 (ja) 2020-12-16

Family

ID=54151248

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017512786A Active JP6802153B2 (ja) 2014-09-03 2015-09-03 免疫スコアを計算するためのシステム及び方法
JP2020144563A Active JP7241723B2 (ja) 2014-09-03 2020-08-28 免疫スコアを計算するためのシステム及び方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020144563A Active JP7241723B2 (ja) 2014-09-03 2020-08-28 免疫スコアを計算するためのシステム及び方法

Country Status (6)

Country Link
US (1) US10127433B2 (OSRAM)
EP (2) EP3195191B1 (OSRAM)
JP (2) JP6802153B2 (OSRAM)
AU (1) AU2015310886A1 (OSRAM)
CA (1) CA2955156C (OSRAM)
WO (1) WO2016034655A2 (OSRAM)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104704348A (zh) * 2012-08-21 2015-06-10 剑桥研究和仪器设备股份有限公司 细胞的可视化和测量
EP3053139B1 (en) * 2013-10-01 2020-10-21 Ventana Medical Systems, Inc. Line-based image registration and cross-image annotation devices, systems and methods
AU2015212984A1 (en) * 2014-01-28 2016-06-23 Ventana Medical Systems, Inc. Adaptive classification for whole slide tissue segmentation
JP2017099616A (ja) * 2015-12-01 2017-06-08 ソニー株式会社 手術用制御装置、手術用制御方法、およびプログラム、並びに手術システム
US9990713B2 (en) * 2016-06-09 2018-06-05 Definiens Ag Detecting and visualizing correlations between measured correlation values and correlation reference values of a pathway
US10572996B2 (en) * 2016-06-28 2020-02-25 Contextvision Ab Method and system for detecting pathological anomalies in a digital pathology image and method for annotating a tissue slide
US11048911B2 (en) 2016-10-27 2021-06-29 Koninklijke Philips N.V. Apparatus for determining cellular composition information in one or more tissue samples
EP3563342B1 (en) * 2016-12-30 2022-03-23 Ventana Medical Systems, Inc. Automated system and method for creating and executing a scoring guide to assist in the analysis of tissue specimen
US11023111B2 (en) * 2017-11-28 2021-06-01 Micron Technology, Inc. System, apparatus, and related method for generating a geospatial interactive composite web-based image map
KR102590482B1 (ko) * 2018-08-30 2023-10-19 어플라이드 머티어리얼스, 인코포레이티드 자동 종양 검출 및 분류를 위한 시스템
CN109493325B (zh) * 2018-10-23 2021-02-26 清华大学 基于ct影像的肿瘤异质性分析系统
CN112912923B (zh) * 2018-10-23 2024-12-24 豪夫迈·罗氏有限公司 基于距离的组织状态确定
US10290101B1 (en) * 2018-12-07 2019-05-14 Sonavista, Inc. Heat map based medical image diagnostic mechanism
WO2020168284A1 (en) * 2019-02-15 2020-08-20 The Regents Of The University Of California Systems and methods for digital pathology
US10957043B2 (en) * 2019-02-28 2021-03-23 Endosoftllc AI systems for detecting and sizing lesions
WO2020190851A1 (en) * 2019-03-15 2020-09-24 Splntellx, Inc. An explainable ai (xai) platform for computational pathology
EP3948776A1 (en) * 2019-03-29 2022-02-09 Howmedica Osteonics Corporation Closed surface fitting for segmentation of orthopedic medical image data
EP3963508B1 (en) * 2019-05-03 2024-09-18 Huron Technologies International Inc. Image diagnostic system, and methods of operating thereof
US20220373536A1 (en) * 2019-10-04 2022-11-24 Cellply S.R.L. High-content analysis method
US20240125700A1 (en) * 2019-10-14 2024-04-18 University Of Southern California Systems, methods and assays for outlier clustering unsupervised learning automated report (ocular)
US11977723B2 (en) * 2019-12-17 2024-05-07 Palantir Technologies Inc. Image tiling and distributive modification
US11908130B2 (en) * 2020-01-03 2024-02-20 Protein Metrics Llc Apparatuses and methods for digital pathology
CN111242242B (zh) * 2020-02-27 2022-04-12 武汉大学 一种基于置信度选择的宫颈组织病理全玻片图像自动分类方法
JP7730487B2 (ja) 2020-05-08 2025-08-28 ルニット インコーポレイテッド 免疫抗癌剤に対する反応を予測する方法及びシステム
WO2021225422A1 (ko) * 2020-05-08 2021-11-11 주식회사 루닛 병리 슬라이드 이미지에 대한 면역 표현형과 연관된 정보를 제공하는 방법 및 장치
CN116235223A (zh) * 2020-07-27 2023-06-06 安捷伦科技有限公司 使用基于目光的跟踪的注释数据收集
CN111899252B (zh) 2020-08-06 2023-10-27 腾讯科技(深圳)有限公司 基于人工智能的病理图像处理方法和装置
WO2022073034A1 (en) * 2020-10-02 2022-04-07 Trimetis Life Sciences Llc Identifying morphologic, histopathologic, and pathologic features with a neural network
US11798165B2 (en) * 2020-10-28 2023-10-24 Sony Group Corporation Tumor detection and segmentation for DPI AI platform routes
CN112330624B (zh) * 2020-11-02 2025-06-06 腾讯科技(深圳)有限公司 医学图像处理方法和装置
US11321843B1 (en) * 2020-12-29 2022-05-03 Rewire Neuro, Inc. Adaptive machine learning system for image based biological sample constituent analysis
JPWO2022201691A1 (OSRAM) * 2021-03-23 2022-09-29
JP2022152980A (ja) * 2021-03-29 2022-10-12 ソニーグループ株式会社 医療用画像解析装置、医療用画像解析方法及び医療用画像解析システム
CN113469939B (zh) * 2021-05-26 2022-05-03 透彻影像(北京)科技有限公司 一种基于特性曲线的her-2免疫组化自动判读系统
CN115700738B (zh) * 2021-07-21 2025-09-09 台达电子工业股份有限公司 用于检体玻片的刮取指引系统及其方法
JP7687406B2 (ja) * 2021-07-29 2025-06-03 株式会社島津製作所 細胞画像解析方法
WO2023146733A1 (en) * 2022-01-31 2023-08-03 Bio-Rad Laboratories, Inc. Computer vision for real-time segmentation of fluorescent biological images
JP7792270B2 (ja) * 2022-03-02 2025-12-25 株式会社Screenホールディングス 疾患評価支援方法および疾患評価支援装置
JP7225458B1 (ja) 2022-05-10 2023-02-20 株式会社エクサウィザーズ 情報処理方法、コンピュータプログラム及び情報処理装置
CN115063796B (zh) * 2022-08-18 2022-11-15 珠海横琴圣澳云智科技有限公司 基于信号点内容约束的细胞分类方法和装置
WO2024049498A1 (en) * 2022-09-02 2024-03-07 Aixmed, Inc. Method and system to obtain sufficient cytology image in cytopathology
CN116758532B (zh) * 2023-05-06 2025-11-07 西安工业大学 基于强度像补偿的点云目标识别方法
CN116646088B (zh) * 2023-07-27 2023-12-01 广东省人民医院 一种预测方法、装置、设备及介质
CN117408657B (zh) * 2023-10-27 2024-05-17 杭州静嘉科技有限公司 一种基于人工智能的人力资源服务系统
CN119833138B (zh) * 2024-12-23 2025-11-07 广东省人民医院 一种基于细胞像素密度的肝细胞癌预后评估方法及系统

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4599191B2 (ja) * 2005-03-01 2010-12-15 国立大学法人神戸大学 画像診断処理装置および画像診断処理プログラム
WO2007145333A1 (ja) * 2006-06-15 2007-12-21 National University Corporation, Tokyo Medical And Dental University 免疫力評価方法、免疫力評価装置、免疫力評価プログラム、及び免疫力評価プログラムを記録した情報記録媒体
US8244021B2 (en) 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
US8194965B2 (en) * 2007-11-19 2012-06-05 Parascript, Llc Method and system of providing a probability distribution to aid the detection of tumors in mammogram images
JP5269637B2 (ja) * 2009-02-13 2013-08-21 オリンパス株式会社 画像処理装置および画像処理プログラム
EP2779089B1 (en) * 2010-07-30 2018-11-14 Fundação D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud Systems and methods for segmentation and processing of tissue images and feature extraction from same for treating, diagnosing, or predicting medical conditions
JP5559642B2 (ja) * 2010-08-30 2014-07-23 富士フイルム株式会社 手術支援装置、手術支援方法および手術支援プログラム
US9159129B2 (en) 2011-07-12 2015-10-13 Definiens Ag Generating image-based diagnostic tests by optimizing image analysis and data mining of co-registered images
US20130203614A1 (en) 2012-02-08 2013-08-08 Jerome Galon Methods for predicting the survival time of a patient suffering from a solid cancer
CA2867359A1 (en) * 2012-03-30 2013-10-03 Clarient Diagnostic Services, Inc. Methods for generating an image of a biological sample
SG11201408107RA (en) * 2012-06-14 2015-01-29 Inserm Inst Nat De La Santé Et De La Rech Médicale Method for quantifying immune cells in tumoral tissues and its applications
JP2014092510A (ja) * 2012-11-06 2014-05-19 Toshiba Corp 医用画像処理装置および医用画像処理プログラム
JP6110992B2 (ja) 2013-06-03 2017-04-05 ベンタナ メディカル システムズ, インコーポレイテッド 画像適応的な生理学的に妥当な色分離
AU2015212984A1 (en) 2014-01-28 2016-06-23 Ventana Medical Systems, Inc. Adaptive classification for whole slide tissue segmentation

Also Published As

Publication number Publication date
JP2021006037A (ja) 2021-01-21
JP2017536801A (ja) 2017-12-14
US10127433B2 (en) 2018-11-13
EP3839812A2 (en) 2021-06-23
WO2016034655A2 (en) 2016-03-10
CA2955156A1 (en) 2016-03-10
EP3195191A2 (en) 2017-07-26
US20170270346A1 (en) 2017-09-21
WO2016034655A3 (en) 2016-06-02
EP3195191B1 (en) 2020-10-21
AU2015310886A1 (en) 2017-02-02
EP3839812A3 (en) 2021-09-01
JP7241723B2 (ja) 2023-03-17
CA2955156C (en) 2024-04-30

Similar Documents

Publication Publication Date Title
JP7241723B2 (ja) 免疫スコアを計算するためのシステム及び方法
US12100146B2 (en) Assessing risk of breast cancer recurrence
Yousif et al. Artificial intelligence applied to breast pathology
US20220156930A1 (en) Cancer risk stratification based on histopathological tissue slide analysis
US10275880B2 (en) Image processing method and system for analyzing a multi-channel image obtained from a biological tissue sample being stained by multiple stains
JP6604960B2 (ja) バイオマーカー陽性の腫瘍細胞を識別するための医用画像解析
JP2021506022A (ja) 生体画像における連帯的細胞および領域分類のための深層学習システムならびに方法
Navikas et al. Semi-automated approaches for interrogating spatial heterogeneity of tissue samples
Balcioglu et al. TME-analyzer: a new interactive and dynamic image analysis tool that identified immune cell distances as predictors for survival of triple negative breast cancer patients
Kung Assessing a Hyperspectral Image Analysis System to Study Tumor and Immune Cell Spatial Organizations Within Lung Tumor Microenvironments

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180830

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180830

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190806

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191106

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20200428

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200828

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20200828

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20200904

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20200908

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20201027

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201126

R150 Certificate of patent or registration of utility model

Ref document number: 6802153

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250