JP6800849B2 - Compositions Containing Acyl Glutamic Acids as First Surfactant or First Anionic Surfactant - Google Patents

Description

The present invention relates to personal care compositions. The composition is preferably an aqueous isotropic personal care composition. The composition is preferably mild (as defined by, for example, a lower percentage of dissolved zein compared to the more severe composition). Preferably, the composition has a good foam volume (a wash signal to many consumers) and is stable. Preferably, the composition is transparent at a pH of 6.5 or less, preferably 6.0 or less (generally the pH of the composition can be from about 3 to 6.5). Preferably, the pH is about 3.5 to 6.0, more preferably about 3.5 to 5.5, more preferably 4.0 to 5.5.

Synthetic detergents such as cationic, anionic, amphoteric and nonionic surfactants are widely used in personal care cleaning compositions. Anionic surfactants generally exhibit excellent cleaning and foaming properties and are therefore typically incorporated into such compositions. However, anionic surfactants also tend to be harsh on the skin.

Consumers desire a milder composition (ie, a composition that is harsh and non-irritating to the skin and skin proteins), so some anionic surfactants are used with other surfactants (eg, nonionic). And / or amphoteric surfactants) are known to replace. Another approach is to associate an anionic surfactant with an amphoteric or cationic compound to form a surfactant complex (see US Pat. No. 4,443,362). Often, these compositions impair foaming and / or cleaning performance.

Another approach to providing mildness is to use milder anionic surfactants. Among such mild anionic surfactants that can be used are N-acylamino acids and salts thereof. Paper "Surfactive N-Acylglutamate: Preparation of Long Chain N-Acylglutamic Acid" (M. Takehaka et al., Journal of the country, Japan, p. 19), page 19 Acylglutamic acid is said to relieve skin irritation caused by other anionic surfactants such as alkylbenzene sulfonates.

Such acyl amino acids are intended as co-surfactants to alleviate the severity of first anionic surfactants, as found in US Pat. No. 6,703,427 by Schmucker et al. They themselves are the first surfactants in the surfactant cleaning system (preferably in the compositions of the present invention) (the "first surfactant" is a surfactant present at a level of 50% or more of all surfactants. (Is), or a first anionic surfactant (“first anionic surfactant” is present in 50% or more of all anionic surfactants, but surfactants other than anionic surfactants are present. , A total of more than 50% of the total surfactant system, or less than 50% of this system)), such surfactants are other in the same composition. Foaming and / or cleaning is expected to be inadequate compared to the use of anionic surfactants. In addition, acyl amino acids are difficult to solubilize in the lower pH range due to the tendency of molecules to precipitate. Therefore, the use of acyl amino acids such as glutamate at low pH is generally unintentional, and glutamate typically precipitates at a pH of about 5.5 or less. Therefore, such glutamate molecules are not intended for use at significant levels in isotropic liquids (which need to be soluble to ensure good clarity). In particular, glutamate is used as a primary surfactant, or a primary anionic surfactant, and at the same time, their amounts are equal to or greater than any other single surfactant present. Use is preferably unintended when more than that. That is, according to the present invention, glutamate is a first anionic surfactant, but if the sum of non-anionic surfactants is greater than the sum of anionic surfactants, glutamate is present. Must be present in equal or greater amounts with any of the surfactants. It is preferred that glutamate is present as the first surfactant.

In addition, glutamate is not as easily structured (eg, self-structured) as other detergents, and thus can make it more difficult to suspend particles and other beneficial agents. Glutamic acid (unless otherwise noted, the term "glutamic acid" or "acylglutamic acid" is used to mean a salt of glutamic acid) as the primary surfactant or as the primary anionic surfactant. It is not intended to be used as (glutamate is co-existing in equal or greater amounts with any other single surfactant present). As the Applicants refer to the co-pending application, while maintaining a relatively clear isotropic liquid, especially at low pH (eg, 6.5 or less, preferably 6.0 or less). , The method of structuring using an external structuring agent is not easily clear. Applicants have found that glutamate is the first surfactant (and by definition the first anionic surfactant), using certain structured polymers to enhance the structure of the liquid (6.5). Below, a co-pending application for a composition that maintains the desired clarity (at a low pH of preferably 6.0 or less, preferably 4.0 to 6.0, more preferably 4.0 to 5.1). Is being submitted.

In short, acylglutamate surfactants are not the type of anionic surfactants that provide excellent foaming, are not easily solubilized (at low pH), and like any other anionic surfactant. Such surfactants are as first surfactants or first anionic surfactants, as they do not self-structure, but any other single surfactant in which the amount of glutamate is present. It has not been considered to be used in a liquid cleaning composition having a low pH (pH 6.5 or less) in an amount equal to or higher than that of the above. In particular, they were not intended for use as first or anionic surfactants in aqueous cleaning compositions, while retaining the ability to maintain good stability and transparency values.

Unexpectedly, Applicants have found that acylglutamate is the first surfactant (a preferred system), or any other single surfactant present at the same time as the first anionic surfactant. It has been found that a low pH aqueous, isotropic composition (transparent and stable), which is present in an amount equal to or larger than that of the above, can be blended. Preferably, the pH of the composition is 6.5 or less. More preferably, the pH is 3.5 to 6.0. More preferably, the pH is 3.5 to 5.5, most preferably 4.0 to 5.5, and even more preferably 4.0 to 5.1. Preferably, the composition is visibly transparent (isotropic). Preferably, the composition is monophasic (isotropic single phase) and has a transparency of 1.0 or less, preferably 0.5 or less (eg, 0.01 to 0.) when measured at a wavelength of 550 nm. 5), more preferably a transparent composition defined by an absorbance value of 0.2 or less.

In addition, Applicants found that the amount of short-chain glutamate was minimized (as a percentage of total glutamate) (to ensure good foaming) and the percentage of glutamate to co-surfactant was maximized (as a percentage of total glutamate). Surprisingly, it has been found to be a preferred composition (reducing the cost of co-surfactant use while maintaining a low pH, clear, monophasic isotropic composition). In a preferred system, glutamate is the first detergent (present at a level of 50% or more, preferably 55% or more of the total surfactant). Preferred systems containing glutamate and certain co-surfactants are also disclosed.

In a co-pending application, Applicants use certain polymers to maintain a predetermined level of transparency while maintaining a relatively low pH (pH 6.5 or less, preferably pH 6.0 or less, preferably pH 6.0 or less, preferably. A composition that further ensures the formation of a stable isotropic liquid at pH 5.5 or less) is disclosed. Such a stable and transparent composition is equivalent to or better than any other single surfactant present at the same time that glutamate is the first or first anionic surfactant. It was not expected to be formed in systems that are present in high quantities.

Various compositions have been disclosed in which glutamate is widely disclosed.

U.S. Pat. No. 6,284,230 of Sako et al. Comprehensively states that a number of surfactants, including glutamate, can be used as first anionic surfactants. However, from Examples, when glutamate is used (Examples 1-5), it is neither a first surfactant (ammonium sulfate in Examples 1-5) nor a first anionic surfactant. it is obvious. In Example 6, sarcosinate (a different acyl amino acid having a single carboxylic acid group) is the first surfactant. When glutamate is used in equal or greater amounts than any other single surfactant, acyl amino acids with two carboxylic acid groups (such as glutamate) are the first surfactant or first anionic surfactant. It is not used as an activator.

U.S. Patent Application Publication No. 2004/0258807 and U.S. Patent Application Publication No. 2011/016506 are two other examples of references that generally disclose glutamate, but again glutamate. Is not used as a first surfactant, or at the same time as a first anionic surfactant, as present in an amount equal to or greater than any other single surfactant present in the composition. Is clear.

The shampoo composition of US Patent Application Publication No. 2005/034895 comprises surfactants, microbiological regulators, rheology additives, conditioning agents and solubilizers. Surfactant compositions include mixtures of glutamate and other surfactants (see Examples 2-5), where glutamate can also be a first surfactant or a first anionic surfactant. It is not used as an agent in an amount equal to or greater than any other single surfactant in the composition.

WO 2010/069500 discloses in Example 1 a composition having composition E, 3.5% glutamate, 3.5% sarcosinate, 8.5% betaine and 2.5% glucoside. There is. In this composition, glutamate is first anionic (present at a level of 50% of the anionic surfactant), but is present in an amount equal to or greater than any other single surfactant present. No (for example, betaine is the most abundant single surfactant present). Glutamate is also not the first surfactant.

As mentioned above, the present invention is that glutamate is the first surfactant (a preferred embodiment) or is present as the first anionic surfactant and at the same time any other single present in the composition. It is required that the surfactant is used in an amount equal to or higher than that of the surfactant, preferably in a larger amount. For the above reasons, systems in which glutamate is used in relatively large amounts (especially as the first surfactant) are clear (isotropy), have good foaming and impair the formation of stable compositions. The formation of such a system was not intended, as it is believed.

U.S. Pat. No. 4,443,362 Japanese Patent No. 29444 U.S. Pat. No. 6,703,427 U.S. Pat. No. 6,284,230 U.S. Patent Application Publication No. 2004/0258807 U.S. Patent Application Publication No. 2011/016506 U.S. Patent Application Publication No. 2005/034895 International Publication No. 2010/069500

M. Takehaka et al., "Surface Active N-Acylglutamate: Preparation of Long Chain N-Acylglutamic Acid", Journal of the American Oil, page 49, Journal Oil

The present invention
1) 0.5 to 35% by weight surfactant system, with anionic surfactants present in 0.5 to 25% by weight, preferably 1 to 15% by weight of the total composition.
a) Axylglutamate is present in at least 50% of all surfactants present (“first surfactant”), or b) Acylglutamate is at a level of at least 50% of anionic surfactants. (Preferably, acylglutamate comprises more than 50% by weight of anionic, more preferably more than 60% by weight of total anionic) and at the same time any other single present in the composition. Also present in equal or greater amounts of surfactants ("first anionic surfactants")
Surfactant system;
2) A co-surfactant (preferably co-surfactant) selected from the group consisting of 0 to 20% by weight, preferably 0.5 to 15% by weight, nonionic, cationic and amphoteric surfactants and mixtures thereof. The surfactant contains an amphoteric surfactant and may further contain a nonionic surfactant, preferably the amphoteric surfactant constitutes 1 to 10% by weight of the total composition);
3) In some cases, 0 to 30%, preferably 0.1 to 10%, more preferably 0.1 to 5% skin or hair beneficial agent; and 4) pH 6.5 or less, preferably pH Balanced water with a pH of 6.0 or less, more preferably a pH of 5.5 or less, more preferably a pH of 5.1 or less.
With respect to the composition containing.

The preferred pH range is about 3.5 to about 5.5, preferably 4.0 to 5.5, especially 4.0 to 5.1.

With respect to the use of optional oils or emollients of component (3), Applicants have made the present invention based on acylglutamic acid salts themselves as first or anionic surfactants. It is first mentioned that it can be defined as a surfactant chassis. The surfactant chassis is preferably a stable, monophasic, isotropic, optically transparent composition. However, when certain optional ingredients (eg, certain oils or emollients) are added to the surfactant chassis, they cannot be completely mixed with the stable isotropic surfactant chassis, resulting in completeness. Formulations may be anisotropic (eg, the composition is no longer "transparent").

Therefore, the present invention is miscible with the surfactant chassis so that it does not contain oil or emollient, or contains a sufficiently small amount of oil or emollient, or is not anisotropic as described above. Complete formulations containing oils or emollients can be included. This formulation is a transparent (isotropic), stable single-phase composition defined by an absorbance value of 1.0 or less at a given wavelength.

The compositions of the present invention may preferably contain immiscible beneficial agents. The present invention is also anisotropic (not optically transparent), but (1) preferably an optically transparent, stable, single-phase surfactant chassis, and (2) a final complete formulation. Includes a complete formulation formed by a combination of optional raw materials (s) present in an amount sufficient to anisotropy the material. Final anisotropic formulations that are not formed from a stable, single-phase, optically transparent surfactant chassis are not considered part of the present invention. Specifically, for example, compositions that are anisotropic before the addition of emollients or oils are not part of the invention.

Preferably, the compositions of the present invention are (whether isotropic in the complete formulation or isotropic at the time of chassis formation and anisotropic with the addition of certain beneficial agents). It is a monophasic isotropic system or is formed from a monophasic isotropic system. Preferably, the composition (again, as the final composition or as an isotropic chassis prior to the addition of the potential anisotropy-forming beneficial agent) maintains optical clarity. Preferably, the composition (as the final isotropic composition or isotropic chassis) is a monophasic system that maintains the optical transparency as defined herein. Preferably, the single-phase optically transparent system is stable and maintains a single optically transparent phase under ambient conditions (about 25 ° C.) for a period of one month or longer, preferably up to about one year. To do.

In a typical preferred composition of the invention, the amount of glutamate surfactant is equal to or greater than all other surfactants (“first surfactant”) and 50% anionic. At the same time as being present above, it can be present in an amount equal to or greater than any one of the other single surfactants (“first anionic surfactant”). Glutamate must be present in an amount equal to or greater than any other single surfactant, even if the sum of the non-anionic surfactants is greater than 50% of the surfactant system. However, glutamate is preferably the first surfactant. In addition, it is preferred to maximize the amount of glutamic acid used and minimize the use of co-surfactants.

Some compositions of the present invention can contain 0 to 10% by weight, preferably 0.1 to 10% by weight, more preferably 0.5 to 7% by weight of structuring agent. Such structuring agents can be water-soluble or water-dispersible polymers, which can be cationic, anionic, amphoteric or nonionic polymers to increase the viscosity and stability of the cleaning agent, and carbohydrate gums. Selected from the group consisting of modified and non-modified starch granules; polyacrylate and methacrylate polymers and copolymers; cationic polymers including cationically modified polysaccharides, cationically modified celluloses and synthetic cationic polymers. In our co-pending application, certain polymers that provide improved stability benefits are disclosed. As mentioned above, the structuring agent may not necessarily be present, but is preferred for stabilizing and suspending the composition, especially for assisting the suspension of the oil-soluble emollient. In a related co-pending application, Applicants have a composition comprising a particular structuring agent that surprisingly maintains a stable, relatively clear (isotropic) liquid over a given low pH range. Claiming a thing.

The compositions of the present invention may contain water-soluble or oil-soluble skin or hair beneficial agents. These may be present at a level of 0 to 30% by weight, preferably 0.1 to 20% by weight, more preferably 0.1 to 10% by weight of the total composition. Some compositions include water-soluble polyhydroxy alcohols. Preferred water-soluble skin beneficial agents include glycerin, sorbitol and polyalkylene glycol (preferable polyalkylene glycol is polyethylene glycol) and mixtures thereof. Preferably, the oil-soluble emollient comprises 30% or less, preferably 10% or less, preferably 5% or less (eg, 0.1 to 5% by weight) of the composition. In some preferred embodiments, no oil-soluble emollient or oil is present.

In the absence of immiscible beneficial agents (such as oil-soluble emollients or oils), the final composition is clear (isotropic). If the amount of immiscible raw material is small enough, the final composition is still transparent (isotropic). However, even if the surfactant chassis is transparent, the present invention may be anisotropic, but is sufficient to make the isotropic surfactant chassis and the complete formulation anisotropic. Complete formulations formed from combinations with amounts of immiscible beneficial agents are also contemplated.

In the present invention, acyl glutamate is present as the "first surfactant" or glutamate is the "first anionic surfactant" (non-anionic is greater than 50% of all anionic surfactants). It relates to an aqueous and clear low pH cleaning composition which is present in an amount equal to or greater than any other single surfactant present). It is not intended that such compositions be included in the compositions of the present invention if glutamate is not present in equal or greater amounts than any other single surfactant.

Glutamate is present in an amount equal to or greater than, preferably greater than, equal to or greater than any other single surfactant, even if it is a primary surfactant or a primary anionic surfactant. Even so, glutamate necessarily constitutes more than 50% of the total anionic surfactant present and, as mentioned above, equal to or greater than any other single surfactant in the composition. It can be seen that it is preferably present in a larger amount. Due to the above properties of glutamate, glutamate is a first or first anionic surfactant, while maintaining a stable monophasic, transparent (isotropy) formulation. Forming a low pH composition was not previously intended. In some preferred compositions, the amount of short chain glutamate (C ₁₀ or less) is minimized (to increase foaming). In some preferred compositions, certain structuring agents are used to enhance structuring (while maintaining transparency) even at very low pH. These monophasic, isotropically transparent compositions are also preferably stable as described above.

Glutamic acid surfactants are milder than other anionic surfactants, but typically do not lather or wash well. Like all acylamino surfactants, acyl glutamates are also difficult to solubilize at low pH, so low pH clear (isotropic) compositions, especially glutamate surfactants, are the subject of choice. It was not intended for use in compositions at the relatively high levels required in the invention (ie, lack of solubility was thought to affect transparency). This is especially true for preferred systems where glutamate is the first surfactant.

Unexpectedly, Applicants have low pH where glutamate is a first surfactant or first anionic surfactant and is present in an amount equal to or greater than any other single surfactant. A stable, transparent (isotropic) composition (as a final formulation or as a surfactant chassis prior to the addition of anisotropy inducer) was made here. The preferred composition maximizes the amount of glutamate used (as a percentage of the total surfactant) in order to minimize expensive co-surfactants. In addition, the preferred composition minimizes the amount of short chain long glutamate used, thereby improving foaming. Finally, in other preferred compositions (as claimed in the co-pending application), the use of certain structuring agents into clear single-phase compositions (as final compositions or surfactant chassis). Allows the use of the maximum amount of glutamate, especially at low pH (eg, 5.5 or less, preferably 5.0 or less). In some preferred systems, the amount of beneficial agent, especially oil or oil-soluble emollient, is minimized (0-30% by weight, preferably 0-10% by weight, preferably 0-5% by weight, preferably 0-5% by weight. not exist).

More specifically, the compositions of the present invention include:
1) 0.5 to 35% by weight of the total composition surfactant system (surfactant chassis), anionic surfactant is present in 0.5 to 25% by weight of the total composition, and acylglutamic acid. Salt,
a) Is it present in 50% or more, preferably 60% or more, more preferably 65% or more of all surfactants present (“first surfactant”), or 50% or more of anionic surfactants. , Preferably above 50%, more preferably above 60%, while being present in an amount equal to or greater than any other single (non-anionic) surfactant in the composition ("first anion"). Surfactants "), by definition, a surfactant system, where both glutamate and secondary anionic surfactant make up 50%, glutamate is still considered a" primary anionic surfactant ". And b) 0% to 20% by weight, preferably 0 to 15% by weight, co-surfactants, selected from the group consisting of nonionic, cationic and amphoteric surfactants and mixtures thereof. A co-surfactant preferably in which 1 to 10% by weight of the amphoteric surfactant is present in the total composition.

The co-surfactant means a surfactant different from the glutamate and a surfactant different from any additional anionic surfactant defining the component (a) above (ie, Other anionic surfactants make up part of component (a), but are used in amounts of 50% or less of total anionic surfactants, where (b) corresponds to non-anionic surfactants);
Depending on the particular co-surfactant used (and to some extent the chain length of glutamate), the amount required to optimize the isotropic system can vary. For example, in systems containing glutamate and amphoacetate, as seen in the Examples, the amount of amphoacetate vs. glutamate required to maximize the isotropic region is (a mixture of decanoyle and cocoyl glutamate). The ratio may be greater than 1/7 (eg, 12.5% amphoacetate to 87.5% glutamate; see Table 2), and further 1 / 1.7 (amphoacetate). Is even more; use a mixture of decanoyle and lauroyl, see Table 1) and may be greater than or equal to (up to 1/1), while co-surfactants used when using CAPHS or cocoyl betaine. May be less (eg, ratios greater than 1/19, see tables 4 and 5 to obtain stable regions with about 5% CAPHS or cocoyl betaine vs. 95% glutamate), and isotropic regions. Become the maximum.

It should be noted that the above are non-limiting examples of some co-surfactants that can be used, but as mentioned above, they are by no means intended to limit the present invention.

2) In some cases, 0 to 30% by weight, preferably 0.1 to 20% by weight, more preferably 0.1 to 10% by weight of skin or hair beneficial agent; preferably this beneficial agent is an oil-soluble emollient. Alternatively, it is a moisturizing oil (however, water-soluble chemicals can also be used). Preferably, the beneficial agent is petrolatum or silicone. Also, preferably, the oil is a vegetable oil or a triglyceride oil. Preferred oils include sunflower seed oil and soybean oil. Other oils are listed below. Preferably, the emollient may be an ester of a long chain (eg, C _14- C ₃₀ ) fatty acid such as isopropyl palmitate or cetyl lactate, preferably any combination of the above; and 3) compositions. The pH is 6.5 or less, preferably 6.0 or less, more preferably 5.5 or less, preferably the pH is 3.5 to 6.0, more preferably 3.5 to 5.5, more preferably 4. Balanced water and other ingredients as defined below, ranging from 0 to 5.5.

As mentioned above, the amount of glutamate may be such that it is the first surfactant as a whole, or glutamate is the first anionic surfactant and at the same time non-anionic. The amount of surfactant may exceed glutamate. If the glutamate is a "first anionic surfactant" but the surfactant system as a whole has less than 50% anionic surfactant, then the glutamate is any other simple substance present in the composition. It must be present in equal or greater amounts with one surfactant.

Further, the composition of the present invention is a transparent (isotropic) single-phase solution. That is, it is a single transparent phase (not a transparent single phase as part of a polyphase solution). This phase is stable (not divided into multiple phases). Transparency means that the absorbance value measured at a wavelength of 550 nm is 1.0 or less, preferably 0.5 or less, and more preferably 0.2 or less.

The composition can be anisotropic if the beneficial agent component (2) is not completely miscible with the surfactant chassis of (1). However, the present invention is also based on the presence of a miscible component (2) such that the final formulation is isotropic, or from the combination of the isotropic chassis of component (1) and the beneficial agent of component (2). It is defined by any of the final anisotropic compositions formed. However, the key to the present invention is the isotropic nature defined by the final composition (isotropic or isotropic or components (1) and (3)) having pH and stability as well as defined clear, monophasic isotropic properties. It is the formation of anisotropy) derived from the chassis.

Surfactant-based anionic surfactant The key to the present invention is that the surfactant system is present in an amount of 0.5 to 35% by weight of the total composition, and this surfactant system contains an anionic surfactant in the total composition. Whether 0.5 to 25% by weight of the product is made up of acyl glutamate and 50% by weight or more of the total surfactant (“first surfactant”) or (overall anionic surfactant) Consists of 50% by weight or more, preferably 60% by weight or more of the total anionic surfactant present (even if less than 50% of the total surfactant) and any other single surfactant in the composition. It should be present in equal or greater amounts with the agent. Preferably, the anionic surfactant comprises 1 to 15% by weight of the total composition, more preferably 2 to 12% of the total composition. In some compositions, anionic surfactants make up 5-12% by weight of the total composition and non-anionic surfactants make up 1-7% by weight of the composition. The amount of glutamate must always be maximized and, as mentioned above, if other surfactants are present in greater amounts than the anionic surfactant (eg, glutamate is the "first surfactant". Even if not), glutamate is present in 50% or more of the anionic surfactant and in an amount equal to or greater than any other single surfactant present.

The acylglutamic acid salt used in the composition of the present invention has the following structure:

It should be noted that either structure occurs at the pH level of the present invention (pH 6.5 or less, preferably 3 to 6.5) and there is also some disalt at higher pH (eg 8 or 9). I want),
In the formula, R is an alkyl or alkenyl group having 8 to 20 carbons, preferably 8 to 16 carbons, more preferably 10 to 14 carbons (generally saturated but partially unsaturated, For example, an oleoil group may be present). Preferably, R is primarily a mixture of C ₁₀ to C ₁₄ . As mentioned above, for preferred foaming levels, minimize the amount of short chain lengths (eg C ₈ and C ₁₀ ) and maximize long chain lengths such as C _12- C ₂₀ , preferably C _12- C _16. Is preferable. C ₁₀ should be minimized, but at least in some embodiments of the invention, the ratio of C ₁₀ to C ₁₂ must be at least 1/5 to ensure isotropic formation. It can be seen that it may be 1/3 or more (somewhat dependent on the co-surfactant used with glutamate). Preferably, the ratio should be no more than 1: 1 regardless of the co-surfactant (if present) used with glutamate.

As used in the examples, the preferred distribution of cocoyl chain lengths herein is typically defined as: 13% C _8- C ₁₀ , 50% C ₁₂ , 18 % C ₁₄ , 8% C ₁₆ and 11% or less C ₁₈ (http://coconutboard.nic.in-English-Article-Gopalakrishna-CFTRI.pdf).

M is a solubilized cation such as sodium, potassium, ammonium or substituted ammonium. The cation is preferably sodium or potassium, more preferably sodium. Sodium salt is preferred.

The pH of the entire composition is typically 6.5 or less, preferably 6.0 or less. The pH is preferably 3 to 6.5, more preferably 3 to 6. More preferably, the pH is 3.5 to less than 6, preferably 3.5 to 5.5, more preferably 4.0 to 5.5, and even more preferably 4.0 to 5.1.

The pKa of acyl glutamate is relatively low (about 5). Surprisingly, Applicants are able to solubilize relatively large amounts of glutamate used, which makes it possible to utilize this anionic surfactant, which is mild compared to other anionic surfactants. I found that it would be.

In addition, surprisingly large amounts of glutamate can be solubilized at low pH, thereby allowing the formation of mild, transparent monophasic isotropic compositions.

Clear and mild cleaning agents are considered highly desirable for consumers. With respect to transparency, Applicants mean that they have an absorbance value of 1.0 or less, preferably 0.5 or less, more preferably 0.2 or less when measured at a wavelength of 550 nm. As mentioned above, the transparency value defines the surfactant chassis and water. The composition can maintain transparency (maintaining isotropic) with the addition of beneficial agents, provided that the final composition is anisotropic but the initial chassis is isotropic as defined. It falls into the definition of the present invention.

Acylglutamates can be used as the only anionic surfactant in the entire composition, but it is desirable to use other anionic surfactants according to the levels defined herein. One preferred coanionic property (contrary to co-surfactant 1 (b)) is sarcosinate (an alkyl salt of C _10- C ₁₄ acyl sarcosinate is preferred sarcosinate, the salt defined by M above. Will be). Another preferred coanionic surfactant is taurate. A salt of C _10- C ₁₄ acyl taurate (eg, sodium cocoyl methyl taurate) is preferred. In general, it is preferable not to use salts that tend to precipitate at lower pH values. Therefore, for example, it is preferable to minimize the amount of acylglycinate (less than 1.0%, preferably less than 0.5%, preferably not present at all).

In general, sarcosinate is expressed in formula:
R ² CON (CH ₃ ) CH ₂ CO ₂ M
Have.

Taurate is the formula:
R ² CONR ³ CH ₂ CH ₂ SO ₃ M
(In the formula, R ³ is methyl);
Glycinate is the formula:
R ² CONHCH ₂ CO ₂ M
(In the formula, R ² above is an alkyl or alkenyl having 8 to 22 carbons, preferably 12 to 18 carbons.
M is the solubilized cation defined above. ).

The compositions of the present invention can have low levels of alkyl ether sulphate, such as sodium lauryl ether sulphate. Low means less than 20% anionic, preferably less than 10%, more preferably less than 5%. In some embodiments, the composition has less than 0.5% alkyl ether sulphate and in some embodiments is substantially free of alkyl ether sulphate. These types of sulphates are not as mild as other surfactants and are preferably minimized.

Cosurfactants The second component of the invention is 0% to 20% by weight, preferably 0.5% to 15% by weight of the total composition, as well as nonionic, cationic and amphoteric surfactants. It may contain a co-surfactant selected from the group consisting of mixtures thereof.

Preferred co-surfactants are amphoteric or zwitterionic surfactants. Preferably, the co-surfactant is amphoteric.

This general class of amphoteric cleaners has the following general structure:

In the formula, R is an alkyl or alkenyl group having 7 to 17 carbons or a general structure.

Carboxamide functional group
In the formula, R ₁ is an alkyl or alkenyl group having 7 to 17 carbons and R ₄ is an alkyl, hydroxyalkyl or carboxyalkyl group having 1 to 3 carbons. R ₂ and R ₃ are independently protons, alkyl, hydroxyalkyl or carboxyalkyl groups with 1 to 3 carbons, or are completely deficient and are subject to the following constraints: When R ₂ and R ₃ are independently alkyl, hydroxyalkyl or carboxyalkyl groups, the nitrogen in the quaternary amine is the cationic charge center. Nitrogen is a tertiary amine if one of R ₂ or R ₃ is an alkyl, hydroxyalkyl or carboxyalkyl group and the other is a proton or is completely deficient. At _a pH well below the pH of the tertiary amine, the other of R ₂ or R ₃ is a proton and the amine is a cationic charge center. At a pH above the pK _a of the tertiary amine in enough, the other of R ₂ or R ₃ is completely deficient, the amine is a charge centers neutral.

Preferred examples of the above amphoteric sex include salts of cocoamide propyl betaine (CAPB), C _10- C ₁₄ alkyl betaine, C _10- C ₁₄ alkyl amphoacetate (eg, lauroamphoacetate) and mixtures thereof.

Another class of amphoteric cleaners is sultane, which has the following general structure:

In the formula, R is an alkyl or alkenyl group having 7 to 17 carbon atoms or a general structure.

Carboxamide functional group
In the formula, R ₁ is an alkyl or alkenyl group having 7 to 17 carbon atoms, and R ₄ is an alkyl, hydroxyalkyl or carboxyalkyl group having 1 to 3 carbon atoms. R ₂ and R ₃ are independently alkyl, hydroxyalkyl or carboxyalkyl groups with 1 to 3 carbon atoms, so the nitrogen in the quaternary amine is the cationic charge center. Preferred amphoteric surfactants in this class are cocamidopropyl hydroxysultaine (CAPHS), lauramidopropyl hydroxysultaine (LAPHS) or lauryl hydroxysultaine (LHS).

A preferred combination of the present invention is a glutamate and sarcosinate salt as an anionic surfactant in combination with a salt of anphoacetate (preferably C _10- C ₁₄ amphoacetate) as a co-surfactant. A preferred combination is a salt of 3 to 8% by weight glutamate with respect to the total composition and 1 to 3% by weight of sarcosinate with respect to the total composition (where preferably the glutamate is the first defined above. It comprises a combination of a monosurfactant or primary anionic) and a salt of 3 to 8% by weight of anphoacetate (particularly an alkali metal salt of acylanphoacetate) relative to the total composition. As mentioned above, glutamate must be present in an amount equal to or greater than any other single surfactant present.

A key aspect of the compositions of the present invention is that the composition (as a fully isotropic composition or as a surfactant chassis prior to forming the composition) is particularly preferably 6.5 or less, preferably 3. It is a stable, transparent, monophasic isotropic liquid at pH values of 5.5 to 6.0, more preferably 3.5 to 5.5, more preferably 4.0 to 5.5.

Glutamate can include a chain length mixture. As mentioned above, short chain lengths C ₈ and C ₁₀ typically do not foam well, so it is typically preferred to minimize them. The use of a mixture of C ₁₀ and cocoyl also helps to extend the region of isotropic transparency, for example compared to a mixture in which only C ₁₀ and C ₁₂ are used. This suggests that some amount of C ₁₄ to C ₂₀ is also preferable.

In some compositions, the surfactant system comprises an alkali metal salt of amphoacetates with a mixture to C ₁₀ and cocoyl glutamate.

Primarily, the present invention is equal to or greater than any other single surfactant present in the composition, at the same time that glutamate is as a primary surfactant or a primary anionic surfactant. It concerns the unexpected observation that it can be used as a quantity. Preferably, glutamate is used as the first surfactant in a low pH, aqueous single-phase composition, the composition being visually transparent. Even if the added beneficial agent causes the formation of the final anisotropic composition, the surfactant chassis before the addition of the anisotropic forming agent is isotropic. Therefore, due to their low pH solubility, it is possible to make mild compositions that are optically transparent (isotropic) (acylamino surfactants are mild). At the same time, because they are low pH compositions, they can provide antibacterial effects while avoiding the use of certain restricted antibacterial agents in certain parts of the world.

Therefore, an anisotropic composition (formed using a glutamate-based isotropic chassis) having a low pH and low pH compatible storage system is another aspect of the present invention.

By using these milder glutamate surfactants at relatively high levels, it is also possible to use less co-surfactants (eg, anphoacetate, CAPB). Amphoacetate can be considered to maintain a wider isotropic region than CAPB (Table 1 and Table 2 vs. Table 3). Similarly, CAPHS and cocobetaine maintain a wider isotropic region than CAPB (Table 4 and 5 to 3). This is especially important for fully formulated isotropic compositions.

When a preferred mixture of C ₁₀ and C _coco (see, eg, Table 2) is used in the present invention, a smaller amount of C ₁₀ glutamate is used as compared to a mixture of C ₁₀ and C ₁₂ (Table 1), etc. Anisotropy is achieved. That is, less C ₁₀ is required to achieve the soluble region (which also helps with foaming). Therefore, systems containing glutamate and amphoteric surfactants are preferred (eg, amphoacetate or cocoamidepropyl betaine). Nonionic surfactants are preferred additional co-surfactants in glutamate / co-surfactant systems.

The examples of the present inventors have shown that it is possible to provide a preferable isotropic composition by changing the distribution of the chain length of the glutamate surfactant. Therefore, to enhance the use of glutamate, co amount of surfactant to minimize, while still obtain a transparent isotropic compositions at low pH, glutamate short chain (e.g. C _8, C ₁₀₎ The amount of can be reduced. Glutamate Nagakusaricho (e.g., C _{12 -C 20)} to use more also helps maintain a good number of bubbles.

As described above, the C ₁₀ depending upon the particular surfactant system should be minimized, in some embodiments of the present invention, to ensure the formation of isotropic compositions defined _{a, C 10} the ratio of _{C 12} must be at least 1/5, 1/3 or more good (preferably 1/1 or less) be.

Preferred stable isotropic compositions have a ratio of about 1/3 or more of C ₁₀ / C ₁₂ acylglutamic acid and about 1 / 1.7 or more (up to 1/1) of lauroamphoacetate / acylglutamic acid. A composition having a salt ratio. To ensure good foaming performance and minimize costs, the ratio of C ₁₀ / C ₁₂ acyl glutamate is preferably less than 1/1 (preferably more than 1/3) and lauroamphoacetate / acyl. The glutamate ratio should be less than 1/1.

Therefore, glutamate is enhanced (less co-surfactant use), higher amount of long-chain glutamate (better foaming, less co-surfactant is particularly good), preferred. The desired benefit of the composition is achieved. Again, there is an improvement in foaming benefits from the composition based on the isotropic surfactant chassis, regardless of whether the final formulation is isotropic or anisotropic.

Preferably, glutamate should be used at a concentration of 50% or higher, more preferably 60% or higher, more preferably greater than 70% of the surfactant system.

One composition that can be used comprises 50% or more glutamate and alkali metal alkyl (C _8- C ₁₄ ) amphiacetate, preferably lauroamphoa acetate. The composition may comprise C ₁₀ and C ₁₂ or a mixture of C ₁₀ and C _coco glutamate (C _coco glutamate is a glutamate having the cocoyl chain length distribution defined above). A mixture of C ₁₀ and C _coco is preferred when it is desirable to minimize the C ₁₀ content, as longer chain lengths typically provide better foaming. Such mixtures to C ₁₀ and _{C coco by} 13% of all R groups glutamate C 8 _{-C 10} are as defined above, preferably _C 8 _{-C 10} chains present in an amount of more than 15% It preferably has a long distribution.

In addition to the absolute amount of co-surfactant (preferably minimized), in some particular compositions, we have the co-surfactant pair required to ensure isotropic formation. An approximate minimum ratio of glutamate can be defined. Therefore, in the anphoacetate / glutamate system, the ratio of amphoacetate to glutamate is preferably about 1/7 or more (up to 1/1) in order to maximize the isotropic region. This ratio appears to be dependent on the chain length of glutamic acid, and another preferred system using a mixture of decanoyl and lauroyl glutamate has an anphoacetate to glutamate ratio of 1: 1.7 or greater (preferably). Glutamic acid is the first surfactant as a whole).

A preferred stable isotropic composition has a C ₁₀ / C _coco acyl glutamate ratio of about 1/3 or more and a lauroamphoacetate / acyl glutamate ratio of about 1/7 or more. The ratio of C ₁₀ / C _coco acyl glutamate is preferably 1/1 or less (preferably about 1/3 or more) in order to ensure good foaming performance, minimize cost and observe an increase in viscosity. Yes, the ratio of lauroamphoacetate / acylglutamic acid must be 1 / 1.7 or less.

Another composition (although not preferred) that can be used comprises 50% or more glutamate and betaine, such as cocoamidepropyl betaine. In such a system, glutamate comprises 60% or more, more preferably 75% or more, more preferably 80% or more of the surfactant system. In the preferred system of the present invention, the ratio of anphoacetate to glutamate can be 1/19 or greater (preferably glutamate is the first surfactant). In such systems, less co-surfactant is required to optimize the isotropic region (eg, compared to the use of cocamidopropyl betaine).

Similarly, another preferred embodiment is a mixture of CAPHS and glutamate, comprising a surfactant system in which the ratio of CAPHS to glutamate is as low as 1/19 or more (up to 1/1). Again, it can be seen that less co-surfactant is required to optimize the isotropic region compared to CAPB.

In general, the preferred composition is one in which glutamate is selected from the group consisting of C10, C12 and C _coco glutamate and mixtures thereof. In a mixture containing C _coco, mixture _preferably, C 8 _{-C 10} is present in an amount from 13 percent based on all R chain length of _glutamate, has a C 8 _{-C 10} chain length distribution. In such a general composition, anfoacetate is preferably a co-surfactant, and the ratio of anfoacetate to glutamate is preferably 1/7 or more, preferably 1/7 to 1/1. Another preferred co-surfactant is selected from the group consisting of betaine, sultaine and mixtures thereof, with a co-surfactant to glutamate ratio of 1/19 or greater, preferably 1/19 to 1 /. It is 1.

A preferred stable isotropic composition has a C ₁₀ / C _coco acylglutamate ratio of about 1/7 or greater (using CAPHS, compared to certain other co-surfactants such as CAPB or amphoacetate. Therefore, less co-surfactant is required to obtain an isotropic region), and the ratio of CAPHS / acylglutamate is about 1/19 or more. The ratio of C ₁₀ / C _coco acyl glutamate is preferably less than 1/1 and the ratio of CAPHS / acyl glutamate is to ensure good foaming performance, minimize cost and observe an increase in viscosity. It is preferably 1/1 or less.

Skin or Hair Beneficial Agents In the same composition of the present invention, 0 to 30% by weight, preferably 0.1 to 10% by weight, more preferably 0.1 to 5% by weight of skin or hair beneficial agents are used. To. As will be appreciated by those skilled in the art, in the compositions of the present invention, the beneficial agent is a compound different from the surfactant represented in the surfactant system. Therefore, it is preferable that the beneficial agent is not a surfactant. Preferably, the beneficial agent is an oil-soluble emollient or moisturizing oil. These are molecules that increase hydration by a variety of mechanisms, including prevention of water loss (obstructing agents), water attraction (wetting agents) or restoration of natural moisturizing factors to the skin (eg,). , Aminolipid). Preferred moisturizers include petrolatum and silicone. Preferably, the moisturizer is a vegetable oil or a triglyceride oil. Preferred oils include sunflower seed oil and soybean oil. The moisturizer may be an ester of a long chain [C _14- C ₃₀ ] fatty acid, such as isopropyl palmitate.

As some natural restorers and moisturizers,
a) Vitamins such as vitamins A and E, and vitamin alkyl esters such as vitamin C alkyl esters;
b) Lipids such as cholesterol, cholesterol esters, lanolin, sucrose esters and pseudoceramides;
c) Liposomal forming material, such as phospholipids, and suitable amphaphilic molecules with two long hydrocarbon chains;
d) Essential fatty acids, polyunsaturated fatty acids, and sources of these substances;
e) Triglycerides of unsaturated fatty acids such as sunflower oil, cherry oil, avocado oil, almond oil;
f) Vegetable butter formed from a mixture of saturated and unsaturated fatty acids, such as shea butter;
g) Sources of minerals such as zinc, magnesium and iron; and h) Silicone oils, gums and modifications thereof such as linear and cyclic polydimethylsiloxane, amino, alkyl and alkylaryl silicone oils;
Can be mentioned.

Water-soluble beneficial agents can also be used. Preferred water-soluble agents include glycerin, sorbitol, polyalkylene glycols and mixtures thereof.

When used, the chassis can still remain transparent, depending on the amount and miscibility of the beneficial agent in the isotropic surfactant chassis. However, even if the beneficial agent provides anisotropy to the chassis, the low pH and foaming benefits described above are still retained.

Although the composition of the present invention does not require an external structuring agent, it is preferable to use a structuring agent when oil-soluble beneficial agents (oil soluble benefits) as described above are used.

Stylizing Agents Preferably, the composition of the invention comprises 0.1 to 10% by weight, preferably 0.5 to 7% by weight of structuring agents. The structuring agent may be a water-soluble or water-dispersible polymer, which can be a cationic, anionic, amphoteric or nonionic polymer for improving viscosity.

Examples of water-soluble or water-dispersible polymers useful in the present invention include carbohydrate gums such as cellulose gum, microcrystalline cellulose, cellulose gel, hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, hydroxymethyl or carboxymethyl cellulose, methyl cellulose. , Ethyl cellulose, guar gum, karaya gum, tragant gum, arabic gum, acavia gum, gum agar, xanthan gum and mixtures thereof; modified and non-modified starch granules having a gelatinization temperature between 30 and 85 ° C., and pregelatinized cold water soluble starch; poly Aacrylate; Carbopol; alkali-soluble emulsion polymers such as Aculyn 28, Aculin 22 or Carbopol Aqua SF1; cationic polymers such as Jaguar C13S, Jaguar C14S, Jaguar C17, or Rohne under the trade name of Guar C16 available from Jaguar C16. Modified polysaccharides containing cationic guar, BF Guar C17 from Lamberti, Aqua D4091 or Aqua D4051 from Aqualon; cationically modified celluloses such as UCARE Polymer JR30 or JR40 from Hercules, N-Hance from Hercules. Hance 3196, N-Hance CPX 215 or N-Hance GPX 196; synthetic cationic polymers such as Nalco's Merquat 100, Merquat 280, Merquat 281 and Merquat 550; cationic starches, eg Staley Inc. Registered trademarks) 100, 200, 300, and 400; Henkel, Inc's Galactasol 800 series guar gum-based cationic galactan mannan; Quadrisct Um-200, and Polymer-24.

Gel-forming polymers such as modified or non-modified starch granules, xanthan gum, Carbopol, alkali-soluble emulsion polymers and cationic guar gum such as Lamberti BF Guar C17 and cationic modified celluloses such as UCARE Polymer JR30® or JR40® , Particularly preferred for the present invention.

Preferred structured copolymers are polymerization products of (1) first ethylenically unsaturated monomer; (2) second ethylenically unsaturated monomer; (3) (meth) acrylate monomer and (4) associative monomer. (For example, an addition polymerization product) (generally a random structure, preferably the copolymer is linear).

The first monomer of (1) has the formula:
HOOC-CR ¹ = CR ^2- COOH (I)
Diacid,
formula:

Cyclic anhydrous precursor of diacid (I),
And in or a combination thereof (wherein, ^{R 1} and ^{R 2,} _H, C 1 -C ₃ alkyl, phenyl, selected from chlorine and bromine, in one or more embodiments, preferably, H, and Individually selected from C _1- C ₃ alkyl).

Preferred monomers include maleic acid and maleic anhydride. The first monomer can constitute 0 to 10% by weight, preferably 0.1 to 5% by weight, based on the total weight of the monomer input. The second monomer (2) may be acrylic acid, methacrylic acid or a combination thereof. The second monomer can be used in an amount of 15-60% by weight based on the total weight of the monomer input. The third (meth) acrylate monomer, C ₈ alkyl esters of C ₁ acrylic acid, may be a C ₈ alkyl esters and combinations thereof C ₁ to methacrylic acid, 30 to 75 weight based on the total monomer charge Can be%
a) The associative monomer has the formula:
R ^4- CH = C (R ³ ) -C (O) -O- (R ⁵ O) _a- R ⁶ (III)
Has (in the formula,
R ³ and R ⁴ are independently selected from H and C _1-3 alkyl.
R ⁵ O is an oxyalkylene unit having 2 to 4 carbon atoms, preferably 2 to 3 carbon atoms, respectively.
R ⁶ is
Linear and branched-chain alkyls with 8 to 40, preferably 8 to 30, more preferably 10 to 22 carbon atoms, and 8 to 40, preferably 8 to 30, alkyl groups, and more. It is preferably selected from linear or branched alkalil, preferably alkylphenyl, having 10 to 22 carbon atoms, and a is 6 to 40, preferably 15 to 35, most preferably 20 to 30. Has a value of).

Of particular interest in one or more embodiments is the formula:
CH ₃ [CH ₂ ] _b- CH _2- [OCH ₂ CH ₂ ] _a- OC (O) C (R ³ ) = CH (R ⁴ ) (IV)
(In the formula, R ³ , R ⁴ and a are as described above, and b has a value of 6 to 38, preferably 6 to 28, more preferably 8 to 20).
It is an associative monomer of.

In the monomers of formula III and formula IV, R ³ is preferably a methyl group and R ⁴ is preferably H. In the above-mentioned associated monomers, a and b represent the number of oxyalkylene and -CH ₂ -repeating unit, respectively, and are generally integers. In one or more embodiments of interest, a is greater than or equal to b.

The associative monomer can be used in an amount of 1 to about 25% by weight, preferably 2 to 20% by weight, more preferably 2 to 15% by weight, based on the total monomer added. In one or more embodiments of particular interest, the amount of associative monomer used is 5 to 12% by weight based on the total monomer added.

In some compositions, the structuring agents found to be particularly effective in maintaining clarity and stability are copolymers of the formula:

(In the formula, a, b, c, d and e represent the weight percentage of each repeating unit monomer contained in the copolymer.
A is a vinyl polyate monomer selected from the group consisting of maleic acid, fumaric acid, itaconic acid, citraconic acid and combinations of these acids and their anhydrides and salts, and B is acrylic acid or methacrylic acid. Acid or salt thereof;
C is a _C 1 -C ₈ esters of acrylic acid or methacrylic acid,
D is the formula (VI)

Is an associative monomer of
(In the equation, each R ₂ is independently H, methyl, -C (= O) OH or -C (= O) OR ₃ );
R _{3 is} C 1 _{-C 30} alkyl;
T is _{-CH 2 C (= O) O} -, - C (= O) O -, - O -, - CH 2 O -, - NHC (= O) NH -, - C (= O) NH-, _{-Ar- (CE 2) z -NHC (} = O) O -, - Ar- (CE 2) z -NHC (= O) NH- or _{-CH 2 CH 2 NHC (= O} ) - and is,
Ar is a divalent aryl,
E is H or methyl,
z is 0 or 1;
k is an integer in the range 0-30; and m is 0 or 1.
However, when k is 0, m is 0, and when k is in the range of 1 to 30, m is 1. (R ₄ O) _n is R ₄ C ₂ H ₄ , C ₃ H. ₆ , C ₄ H ₈ or a mixture thereof, homopolymers of C _2- C ₄ -oxyalkylene units in which n is an integer in the range 5 to 250, polyoxyalkylenes which are random copolymers or block copolymers;
Y is _{-R 4 O -, - R 4} H -, - C (= O) -, - C (= O) NH-, R 4 NHC (= O) NH- or -C (= O) NHC (= O);
R ₅ is C _8- C ₄₀ linear alkyl, C _8- C ₄₀ branched alkyl, C _8- C ₄₀ carbocyclic alkyl, C _2- C ₄₀ alkyl substituted phenyl, aryl substituted C _2- C ₄₀ alkyl and C. ₈ -C ₈₀ substituted or unsubstituted alkyl selected from the group consisting of complex ester; wherein R ₅ alkyl groups, hydroxy, may contain one or more substituents selected from the group consisting of alkoxy and halogen ;
If present, E is a crosslinkable monomer for introducing crosslinkable molecular weight control, comprising a polyfunctional unit having multiple reactive functional groups selected from the group consisting of vinyl, allyl and a functional mixture thereof. The groups A, B, C, D and E are covalently attached to each other in a manner selected from random, blocked or crosslinked copolymer forms).

The amount of "a" may range from about 0 to 10% by weight, preferably from 0.1 to about 5% by weight, and the amount of "b" from about 10 to about 80% by weight, preferably from 15. The amount of "c" may be in the range of about 30 to about 85% by weight, preferably in the range of 30 to 75% by weight, and the amount of "d" may be in the range of about 1 to about 1 to about. It may be in the range of 25% by weight and the amount of "e" may be in the range of 0 to about 5% by weight of all copolymers.

Some compositions can contain 0.005 to 5% by weight of water-soluble polymer.

Examples of water-soluble polymers include high molecular weight polyethylene glycols such as Polyox® WSR-205 (PEG14M), Polyox® WSR-N-60K (PEG45M) and Polyox® WSR-301 (registered trademark). PEG90M); Carbohydrate gums such as cellulose gums. Hydroxyethyl cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, methyl cellulose, ethyl cellulose, guar gum, karaya gum, tragacant gum, arabic gum, acacia gum, gum agar and xanthan gum; modified starch granules and pregelatinized cold water soluble starch; cationic polymers, eg, trade names. Modified polysaccharides containing cationic guar available from Rhodia under Jaguar®; cationically modified celluloses such as UCARE Polymer JR30 or JR40 from Amerchols; N-Hance® 3000, N-Hance from Hercules. (Registered Trademarks) 3196, N-Hance® GPX 215 or N-Hance® GPX 196; Synthetic Cationic Polymers, eg, Merquat® 100, Merquat® sold by Nalco. 280, Polymer® 281 and Merquat® 550. Water-soluble polymers can be used alone or in combination of two or more polymers from the same or different classes. Polyox® WSR-301 (PEG90M) and Polyox® WSR-N-60K (PEG45M) of high molecular weight polyethylene glycol and guar derivatives such as Jaguar® S, Jaguar® C17 and Jaguar® C13 and synthetic cationic polymers such as Merquat® 100 are particularly desirable.

Preservatives Personal product formulations provide a good medium for microbial growth. The action of microorganisms is evident in terms of hydrolysis, oxidation or reduction and can cause off-flavors, color changes, adverse changes in pH, emulsion destruction, and changes in product texture. Therefore, a good preservation system is needed to prevent microbial growth, product spoilage, and skin and hair infections. Preservatives must be effective against Gram-negative and Gram-positive bacteria as well as fungi (molds and yeasts).

Effective preservatives are chemicals that prevent the growth of microorganisms in the product, make the product safer, and extend shelf life.

Optimal storage systems must provide wide spectral activity and be effective over the shelf life of the product. Preservatives must be water soluble as the microorganisms grow in the aqueous phase of the formulation. If the formulation contains significant levels of oil, this system should favor distribution to the aqueous phase. Ideally, the storage system should be effective, colorless and safe to use over a wide pH range. It should be non-irritating, non-sensitizing and preferably non-toxic. Ideally, the symbiotic organisms should be safely left on the skin after the formulation has been applied to the skin, hair or mucous membranes, while eliminating pathogenic organisms in the formulation during storage.

Some preferred preservatives include:
1) Parabens such as methyl-, ethyl-, propyl-, iso-butyl- and butyl-paraben;
2) Formaldehyde-releasing preservatives such as formaldehyde, quaternium-15, dimethyl-dimethyl (DMDM) hydantoin, imidazolidinyl urea, diazoridinyl urea, sodium hydroxymethylglycinate and 2-bromo-2-nitropropane-1,3-diol;
3) Isothiazolinone, such as chloromethyl-isothiazolinone (CMIT), methyl-isothiazolinone (MIT) or benzisothiazolinone (BIT);
4) Halogen organic active substances such as iodopropynyl butyl carbamate and methyl-dibromoglutaronitrile (glutaranitile);
5) Organic acids such as benzoic acid, dehydroacetic acid, salicylic acid, lactic acid and sorbic acid;
6) Others containing chloroacetamide, phenyloxyethanol and triclosan.

Additional suitable preservatives for personal care products are described in "Preservatives for Cosmetics Manual, 2nd edition", David S. ^et al. Steinbens, 2006 and "Preservatives for Cosmetics", D.C. C. Steinberg, Allured Publishing Corp. , ISBN # 0-93170-54-5. Such agents are typically used in 0.1 to 1%, more preferably 0.5 to 0.7% of personal product formulations.

The organic acid is particularly preferred. Organic acids having a pKa of about 4.0 to 5.5, preferably between 4.0 and 5.0 are particularly preferred.

Preservatives are not ideal for all situations. For example, parabens are relatively non-irritating, but preferentially split in the oil phase and are inactivated by some detergents. Preservatives that retain formaldehyde have a broad spectrum of effectiveness, but are irritating and are banned in some countries.

Applicants have filed a co-pending application for low pH based isotropic compositions having a particular preservative system.

The compositions of the application, and the particular compositions of the invention having a preferred pH of about 3 to 5.1, preferably contain the organic acids described above as preservatives. Specifically, organic acids having a pKa of 4.0 to 5.5, preferably 4.2 to 5.1, are preferred.

More specifically, the composition preferably has a pH less than 1 pH unit, more preferably less than 0.5 pH unit higher than the pKa of the organic acid. Within such a narrow pH range, organic acids appear to remain largely in the non-dissociated form, which is the form required for activity against microorganisms.

Thus, for example, benzoic acid has a pKa of 4.2 and is ideally used for compositions with a pH of less than 5.2, preferably 4.7 or less (as in a preferred embodiment of the invention). Is.

As mentioned above, benzoic acid is the preferred preservative.

The compositions of the present invention may further comprise one or more additional ingredients. Non-limiting examples of such additional ingredients include, for example, colorants, pigments, opacifying agents, fragrances (whether encapsulated or present as free fragrances), sensory oils, vitamins and vitamin derivatives, polishing. Agents, optics (including, for example, reflective particles and interfering pigments), pH regulators, vegetable extracts, essential oils, preservatives, antioxidants, antibacterial agents, viscosity regulators, water retention agents, chin whiskers, sensation agents (Sensory agents), fatty acid soaps and skin and / or hair beneficial agents (eg, aloe, allantin, pantenol, alpha-hydroxyic acid, phospholipids, vegetable oils, and amino acids can be mentioned). The choice and amount of any individual additional ingredient depends on factors including the particular ingredient, the desired properties and the intent of use of the composition in which it is used. For example, the fragrance is typically used in an amount of 0.1 to 3.0% by weight or more of the composition. In many compositions, the total amount of such additional ingredients is 0.01 to 30% by weight, more particularly 0.1 to 15% by weight, and even more specifically 1 to 10 based on the total weight of the composition. By weight%. In one or more embodiments, the total amount of such additional optional ingredients is 0.5 to 5% by weight. Other ingredients, such as fatty acid soaps, may be present at levels up to 10% by weight based on the total weight of the composition.

The composition is aqueous and typically contains 30 to 90% by weight of water. After considering all the above ingredients, balance with water.

Protocol Transparency The transparency of a sample is measured by measuring its absorbance at a wavelength of λ = 550 nm. A fully formulated sample (approximately 300 μl) is added undiluted to a 96-well plate and read with a microplate reader (SpectraMax® 340PC, Molecular Device). Ideally, the permeable sample has zero absorbance (ie, 100% permeability). In the present invention, a sample having an absorbance of less than 1.5, more preferably less than 1, more preferably less than 0.5, even more preferably less than 0.2 has a visually acceptable permeability (transparency). Defined as bringing.

[Example]
The demonstration system was constructed by weighing a predetermined mass of surfactant into a tare-weighed beaker. Applicants prepared an example system with a total surfactant of 15% on a scale of 50 g. The desired blend of glutamate surfactants was first weighed, followed by any co-surfactant. The total level of surfactant and co-surfactant was always 7.5 g. Next, a calculated amount of citric acid was added to obtain a final pH of about 4.5. The system was then weighed 50 g with water and heated to 75 ° C. with stirring. After stirring for 5 to 15 minutes, the resulting monophasic isotropic system was removed from heat and cooled to room temperature. After cooling, the pH was finely adjusted to pH 4.5 with a 50% citric acid solution and water was added to restore the loss during heating. After equilibrating the system at room temperature for 2 weeks, observation was made to construct a phase map.

To demonstrate a composition comprising a surfactant system in which glutamate is the primary surfactant, Applicants have (1) a mixture of C ₁₀ / C ₁₂ glutamate and anphoacetate; (2). a mixture of C ₁₀ / _{C coco} glutamate and _{amphoacetates; (3) C 10 / C} coco mixture of glutamate and cocamidopropyl betaine _{(CAPB); (4) C} 10 / C coco glutamate and cocamidopropyl Various systems were prepared containing a mixture with hydroxylsultaine (CAPHS); (5) a mixture of C ₁₀ / C _coco glutamate and cocobetaine.

The results are described as follows.

[Example 1]
Stability map of lauroyl glutamate / amphacetate system with 15% total surfactant and pH 4.5. As described above, lauroyl glutamate was mixed with decanoyl glutamate. An isotropic system having an absorbance value of less than 0.2 at symbol I = 550 nm, and an X = two-phase system. In these systems, the left column represents the percentage of C _{10 to} the percentage of C ₁₀ and C ₁₂ , for example 75, where 75% of the total glutamate present is C ₁₀ and 25% is C ₁₂ . Represents a system. The top row is% of anphoacetate and the rest is glutamate. Thus, 12.5 represents a system in which 87.5% of the surfactant is a glutamate blend and 12.5% is anphoacetate. The total surfactant present is 15% in all cases and the rest is water with a small amount of citric acid.

In this example, the preferred stable isotropic composition has a C ₁₀ / C ₁₂ acyl glutamate ratio of about 1/3 or more and a lauroamphoacetate / acyl glutamate ratio of about 1 / 1.7. You can see that it is the above (maximum 1/1). To ensure good foaming performance and minimize costs, the ratio of C ₁₀ / C ₁₂ acyl glutamate should be less than 1/1 (preferably more than 1/3) and lauroamphoacetate /. The ratio of acyl glutamate should be less than 1/1.

[Example 2]
Stability map of cocoyl glutamate / amphacetate system with 15% total surfactant and pH 4.5. As described above, cocoyl glutamate was mixed with decanoyl glutamate. An isotropic system having an absorbance value of less than 0.2 at symbol I = 550 nm, and an X = two-phase system. Percentages are measured as shown in Table 1 of Example 1.

A preferred stable isotropic composition is one in which the ratio of C ₁₀ / C _coco acyl glutamate is about 1/3 or more and the ratio of lauroamphoacetate / acyl glutamate is about 1/7 or more. It seems that you can understand. In order to ensure good foam performance, minimize cost and observe an increase in viscosity, the ratio of C ₁₀ / C _coco acyl glutamate is 1/1 or less (preferably about 1/3 or more). The ratio of lauroamphoacetate / acylglutamate should be 1 / 1.7 or less.

[Example 3]
Stability map of cocoyl glutamate / CAPB system with 15% total surfactant and pH 4.5. As described above, cocoyl glutamate was mixed with decanoyl glutamate. An isotropic system having an absorbance value of less than 0.2 at symbol I = 550 nm, and an X = two-phase system. Percentages are measured as shown in Table 1.

As can be seen from Examples 1 to 3, when a mixture of C ₁₀ and C _coco was used (Table 2), a smaller amount of C ₁₀ glutamate was used compared to a mixture of C ₁₀ and C ₁₂ (Table 1). Isotropic regions are achieved using. That is, less C ₁₀ is required to achieve the soluble region (which also helps with foaming). The system is glutamic acid + co-surfactant (eg, amphoacetate or cocoamidepropyl betaine). Nonionic surfactants are preferred co-surfactants in glutamate / co-surfactant systems. If the co-surfactant used is CAPB rather than anphoacetate (Table 3 vs. Table 2), some solubility benefit is lost at lower levels of C ₁₀ . However, even if the solubility is lost, the benefits of low pH (because of the alternative storage system) and foaming are preserved by using the high glutamate surfactant chassis.

[Example 4]
Stability map of cocoyl glutamate / cocoamide propyl hydroxylsultaine (CAPHS) system with 15% total surfactant and pH 4.5. As described above, cocoyl glutamate was mixed with decanoyl glutamate. An isotropic system having an absorbance value of less than 0.2 at symbol I = 550 nm, and an X = two-phase system. Percentages are measured as shown in Table 1.

A preferred stable isotropic composition has a C ₁₀ / C _coco acylglutamate ratio of about 1/7 or greater (using CAPHS, compared to certain other co-surfactants such as CAPB or amphoacetate. Therefore, it can be seen that the ratio of CAPHS / acylglutamate is about 1/19 or more of the composition (less co-surfactant is required to obtain the isotropic region). The ratio of C ₁₀ / C _coco acyl glutamate must be less than 1/1 and the ratio of CAPHS / acyl glutamate to ensure good foaming performance, minimize cost and observe an increase in viscosity. Must be less than or equal to 1/1.

[Example 5]
Stability map of cocoyl glutamate / cocobetaine system with 15% total surfactant and pH 4.5. As described above, cocoyl glutamate was mixed with decanoyl glutamate. An isotropic system having an absorbance value of less than 0.2 at the symbol I-550 nm, an X = two-phase system. Percentages are measured as shown in Table 1.

Preferred stable isotropic compositions have a C ₁₀ / C _coco acyl glutamate ratio of about 1/7 or greater and a cocobetaine / acyl glutamate ratio of about 1/19 or higher (specific other co-s). It will be seen that the composition requires less co-surfactant to obtain an isotropic region as compared to the use of a surfactant. In order to ensure good foaming performance, minimize cost and observe an increase in viscosity, the ratio of C ₁₀ / C _coco acyl glutamate must be less than 1/1 and that of cocobetaine / acyl glutamate. The ratio must be 1/1 or less.

As can be seen from Examples 2, 4 and 5, broad isotropic when a glutamate mixture of C ₁₀ and C _coco is used in combination with a co-surfactant selected from the list of preferred amphoteric surfactants. A stable region is provided. More specifically, when a short chain length glutamate (decanoyl glutamate) and a long chain length glutamate (cocoyl glutamate) are blended, the glutamate constitutes 100% of the surfactant system, pH 4.5. Isotropic system is obtained in. In addition, the addition of a preferred amphoteric cosurfactant to the glutamate blend results in an isotropic system in which glutamate comprises 50% or more of the surfactant system and 100% of the total anionic surfactant system. On the other hand, if the long chain length is abundant in the glutamate blend, foaming is improved. Again, the foaming benefit is retained even if the beneficial agents in the final system form an anisotropic composition.

[Example 6-8]
In Examples 6-8, the finished formulation is prepared by adding surfactant, starch and 70% free water to a tare weighed container immersed in a water bath with overhead mixing. did. Stir until the ingredients are uniformly mixed, then continue stirring while raising the water bath temperature to 70 ° C. At that temperature, Jaguar (pre-dispersed in glycerin) and PEG are added in conjunction with citric acid. When cooling is started and the water bath reaches 35 ° C., other components are added. The final pH and water content are then adjusted.

Example 6 is typical of conventional storage systems and can be used over a wide pH range, but its application is regionally limited. In contrast, Example 7 illustrates a preservation system that is preferred in those areas but will only function below pH 5.0. This exemplary formulation provides an effective product form for practicing this preservation system. Both examples resulted in a stable isotropic monophasic system. Example 8 is still stable to physical phase separation, but with an optional beneficial material (in this case Puregel® B990, starch thickener) that makes the final system anisotropic. This is an example of the finished formulation contained.

[Example 9-11]
In Examples 9-11, the finished formulations were prepared as described in Examples 6-8.

Example 9 is typical of conventional storage systems and can be used over a wide pH range, but its application is regionally limited. In contrast, Example 10 illustrates a preservation system that is preferred in those areas but will only work below pH 5.0. This exemplary formulation provides an effective product form for practicing this preservation system. Both examples resulted in a stable isotropic single-phase surfactant chassis. Example 10 is still stable to physical phase separation, but is an optional beneficial ingredient that makes the final system anisotropic (in this case, skin softening oils soybean oil and hydrogenated soybean oil). Is an example of a finished formulation containing. Similarly, Example 11 is still stable to physical phase separation, but is an optional beneficial ingredient that makes the final system anisotropic (skin softening oil and sensory regulators, petrolatum and polybutene, respectively). ) Is an example of a finished formulation containing.

Claims (16)

a) A surfactant system of 0.5 to 35% by weight of the total composition, comprising an anionic surfactant containing acylglutamic acid present in an amount of 50% by weight or more of the total surfactant present.
An interface further comprising a co-surfactant, which is a non-anionic surfactant selected from the group consisting of 0 to 20% by weight of the total composition, nonionic, cationic, amphoteric surfactants and mixtures thereof. Activator system;
b) 0 to 30% by weight of the total composition water-soluble or oil-soluble, non-surfactant skin or hair beneficial agent; and c) containing water.
The pH is 5.5 or less and
The acyl glutamates _are a mixture to _{C 10} and _{C coco glutamate,} to _{C 10} and _{C coco} having a chain length distribution of _C 8 _{-C 10} which C 8 _{-C 10} is present in an amount of more than 13% It said mixture or containing, or the acyl glutamates _are specific to _{C 10} pairs _{C 12} is at least _1/5, comprises a mixture to _{C 10} and _{C 12} glutamate,
The acylglutamic acid salt has a cation that is sodium or potassium.
Clear cleaning composition. The composition according to claim 1, wherein 300 μl is added to a 96-well plate without dilution and is defined by an absorbance value of 1.0 or less when measured at a wavelength of 550 nm. The composition according to claim 1 or 2, which comprises 0.5 to 15% of the co-surfactant. The composition according to any one of claims 1 to 3, wherein the co-surfactant contains an amphoteric surfactant. The composition according to any one of claims 1 to 4, further comprising 0.1% by weight to 5% by weight of the beneficial agent. The composition according to any one of claims 1 to 5, wherein the beneficial agent is an oil-soluble emollient or moisturizing oil. The composition according to any one of claims 1 to 6, wherein the pH of the composition is 3.5 to 5.5. The composition according to claim 7, wherein the pH is 4.0 to 5.5. The composition according to claim 8, wherein the pH is 4 to 5.1. The composition according to any one of claims 1 to 9, further comprising a structuring agent. formula:

(In the formula, a, b, c, d and e represent the weight percentage of each repeating unit monomer contained in the copolymer;
A is a vinyl polyate monomer selected from the group consisting of maleic acid, fumaric acid, itaconic acid, citraconic acid and combinations of these acids and their anhydrides and salts.
And
B is acrylic acid or methacrylic acid or a salt thereof,
C is a _C 1 -C ₈ esters of acrylic acid or methacrylic acid,
D is equation (II)

Is an associative monomer of
(In the equation, each R ₂ is independently H, methyl, -C (= O) OH or -C (= O) OR ₃ )
R ₃ is C _1- C ₃₀ alkyl;
T is _{-CH 2 C (= O) O} -, - C (= O) O -, - O -, - CH 2 O -, - NHC (= O) NH -, - C (= O) NH-, _{-Ar- (CE 2) z -NHC (} = O) O -, - Ar- (CE 2) z -NHC (= O) NH- or _{-CH 2 CH 2 NHC (= O} ) - and is,
Ar is a divalent aryl,
E is H or methyl,
z is 0 or 1 and
k is an integer in the range 0-30, and m is 0 or 1.
However, when k is 0, m is 0, and when k is in the range of 1 to 30, m is 1.
(R ₄ O) _n is R ₄ is C ₂ H ₄ , C ₃ H ₆ , C ₄ H ₈ or a mixture thereof.
C ₂ -C n is an integer ranging from 5 250 4 _- homopolymers of oxyalkylene units is a polyoxyalkylene random copolymers or block copolymers,
Y _{is, -R 4 O -, - R} 4 H -, - C (= O) -, - C (= O) NH -, = R 4 NHC (= O) NH- or -C (= O) NHC (= O)-and
R ₅ is C _8- C ₄₀ linear alkyl, C _8- C ₄₀ branched alkyl, C _8- C ₄₀ carbocyclic alkyl, C _2- C ₄₀ alkyl substituted phenyl, aryl substituted C _2- C ₄₀ alkyl and C. ₈ -C ₈₀ substituted or unsubstituted alkyl selected from the group consisting of complex ester, wherein R ₅ alkyl groups, hydroxy, may contain one or more substituents selected from the group consisting of alkoxy and halogen ,
If present, E is a crosslinkable monomer for introducing a crosslinkable control molecular weight, comprising a polyfunctional unit having multiple reactive functional groups selected from the group consisting of vinyl, allyl and a functional mixture thereof. The groups A, B, C, D and E are covalently bonded to each other in a mode selected from random, block or crosslinked copolymer forms).
The composition according to claim 10, which comprises a structuring agent having the above. The composition according to any one of claims 1 to 11, further comprising an immiscible beneficial agent. The acylglutamate is selected from the group consisting of C ₁₀ , C ₁₂ and C _coco glutamate and mixtures thereof, the co-surfactant is anphoacetate, and the ratio of anphoacetate to the acylglutamate is 1 /. The composition according to any one of claims 1 to 12, which is 7 or more. The composition according to claim 13, wherein the ratio of anphoacetate to acylglutamic acid is 1/7 to 1/1. The acyl glutamate is selected from the group consisting of C ₁₀ , C ₁₂ and C _coco glutamate and mixtures thereof, and the cosurfactant is selected from the group consisting of betaine, sultaine and mixtures thereof, said co-surfactant. The composition according to any one of claims 1 to 12 , wherein the ratio of the activator to the acylglutamic acid salt is 1/19 or more. The composition according to claim 15, wherein the ratio of the co-surfactant to the acylglutamic acid salt is 1/19 to 1/1.