JP6797673B2 - Hair growth composition - Google Patents

Description

The present invention relates to a hair growth composition.

As active ingredients, various ingredients such as peripheral vasodilators, hair root activators, anti-inflammatory agents, sebum secretion inhibitors, and plant extracts are used in hair growth compositions.

For example, Patent Document 1 proposes a hair-growth composition containing a plant extract such as Ogon extract.

Japanese Unexamined Patent Publication No. 5-97631

In view of the above-mentioned prior art, the present inventors have developed a hair-growth composition containing an augon extract, in which a zinc compound is added as a component for improving the firmness and elasticity of hair in addition to the augon extract. , Faced the problem of white turbidity in the hair growth composition.

The present invention has been made in view of the above-mentioned problems, and an object of the present invention is to provide a hair-growth composition containing an augon extract and a zinc compound, in which cloudiness is suppressed.

As a result of diligent studies to solve the above-mentioned problems, the present inventors have surprisingly made the hair-growth composition cloudy by adding a specific diester described later in addition to the ginger extract and the zinc compound. It was found that it can suppress. The present inventors have completed the present invention by repeating further research based on such findings.

That is, the present invention includes the hair growth composition described in the following section.
Item 1.
(A): Ogon extract,
(B): Zinc compound, and (C): Cyclohexanedicarboxylic acid,
General formula (1):
R- (OCH ₂ CH ₂ ) _n- OH (1)
[In the general formula (1), R represents an alkyl group having 1 to 12 carbon atoms, and n represents an integer of 2 to 11. ]
A composition for hair growth containing a diester with a polyoxyethylene monoalkyl ether represented by.
Item 2.
The hair-growth composition according to Item 1, wherein the mass ratio of the C component to the B component (C component / B component) is larger than 3.
Item 3.
The zinc compounds include zinc gluconate, zinc chloride, zinc undecylate, zinc stearate, zinc paraphenol sulfonate, zinc palmitate, zinc myristate, zinc laurate, basic zinc carbonate, zinc sulfate, zinc oxide, and The hair-growth composition according to Item 1 or 2, which is at least one selected from the group consisting of low-temperature calcined zinc oxide.
Item 4.
The composition for hair growth according to any one of Items 1 to 3 above, wherein the cyclohexanedicarboxylic acid is 1,4-cyclohexanedicarboxylic acid.
Item 5.
The composition for hair growth according to any one of Items 1 to 4, wherein the polyoxyethylene monoalkyl ether is diethylene glycol monoethyl ether.
Item 6.
The composition for hair growth according to any one of Items 1 to 5, which contains 0.1 to 10% by mass of the B component and 0.1 to 10% by mass of the C component.
Item 7.
The composition for hair growth according to any one of Items 1 to 6, which contains 0.1 to 10% by mass of the component A.

According to the present invention, it is possible to provide a hair-growth composition having excellent appearance properties in which cloudiness is suppressed.

It is a photograph which shows the result of a test example. In FIG. 1, it corresponds to Examples 1 to 6 and Comparative Examples 1 to 5 in order from the left.

Hereinafter, the present invention will be described in detail.

The present invention includes a composition for hair growth. The hair-growth composition of the present invention
(A) Ogon extract,
With (B) zinc compound and (C) cyclohexanedicarboxylic acid, general formula (1):
R- (OCH ₂ CH ₂ ) _n- OH (1)
[In the general formula (1), R represents an alkyl group having 1 to 12 carbon atoms, and n represents an integer of 2 to 11. ]
Includes a diester with a polyoxyethylene monoalkyl ether represented by.

In the present specification, the eugon extract is referred to as "A component", the zinc compound is referred to as "B component", and the diester of cyclohexanedicarboxylic acid and the polyoxyethylene monoalkyl ether represented by the general formula (1) is simply referred to as "component A". It may be referred to as "diester" or "C component", respectively.

Scutellaria baicalensis extract, which is a component A, is an extract of Scutellaria baicalensis root and has a hair-growth and hair-growth effect. The method for producing the Ogon extract is not particularly limited, and the extract can be produced by a known method. Further, the extraction solvent is not particularly limited, and for example, known solvents such as water, alcohol, ether, and chloroform, which are usually used for extraction, can be used. In addition, a commercially available product can be used as the Ogon extract.

The content of the augon extract contained in the hair-growth composition of the present invention is not particularly limited as long as the hair-growth effect is exhibited. For example, the entire hair-growth composition of the present invention is used as a reference (100% by mass). About 0.1 to 10% by mass, preferably about 1 to 10% by mass, more preferably about 2 to 9% by mass, still more preferably about 2 to 8% by mass, still more preferably about 2 to 7% by mass. It is particularly preferably about 3 to 6% by mass, and most preferably about 4 to 5% by mass.

The zinc compound, which is the B component, has an action of imparting firmness and elasticity to the hair. The zinc compound is not particularly limited as long as it is a zinc compound that can be blended in the hair growth composition, and a known zinc compound can be used. For example, zinc gluconate, zinc chloride, zinc undecylate, zinc stearate, zinc paraphenol sulfonate, zinc palmitate, zinc myristate, zinc laurate, basic zinc carbonate, zinc sulfate, zinc oxide, and low temperature calcined oxidation. Examples include zinc. Of these, zinc gluconate is preferable. Further, the zinc compound may be used alone or in combination of two or more. When two or more kinds are mixed and used, the mixing ratio is not particularly limited and can be appropriately determined.

The content of the zinc compound contained in the hair-growth composition of the present invention is not particularly limited as long as it exerts the effect of imparting elasticity to the hair. For example, the entire hair-growth composition of the present invention. About 0.1 to 10% by mass, preferably about 0.1 to 5% by mass, more preferably about 0.1 to 4% by mass, still more preferably 0.1 to 3% by mass, based on (100% by mass). %, More preferably about 0.1 to 2% by mass, particularly preferably about 0.1 to 1% by mass, and most preferably about 0.1 to 0.75% by mass.

The diester which is the C component is cyclohexanedicarboxylic acid and the general formula (1) :.
R- (OCH ₂ CH ₂ ) _n- OH (1)
[In the general formula (1), R represents an alkyl group having 1 to 12 carbon atoms, and n represents an integer of 2 to 11. ]
It is a diester with a polyoxyethylene monoalkyl ether represented by.

The diester is an ester oil having both hydrophilic and lipophilic functions, and has an action of promoting the penetration of the active ingredient into hair and skin. Furthermore, although not limited interpretation is desired, the use of the diester can suppress cloudiness of the composition containing the eugon extract and the zinc compound.

The cyclohexanedicarboxylic acid constituting the diester is not particularly limited, and examples thereof include 1,2-cyclohexanedicarboxylic acid, 1,3-cyclohexanedicarboxylic acid, and 1,4-cyclohexanedicarboxylic acid. Of these, 1,4-cyclohexanedicarboxylic acid is preferable. The cyclohexanedicarboxylic acid has geometric isomers of cis and trans isomers, but the cyclohexanedicarboxylic acid constituting the diester is any of cis and trans isomers, or a mixture of cis and trans isomers. May be good.

The polyoxyethylene monoalkyl ether constituting the diester is a compound represented by the above general formula (1). In the general formula (1), R represents an alkyl group having 1 to 12 carbon atoms, and n represents an integer of 2 to 11.

The alkyl group having 1 to 12 carbon atoms represented by R may be linear, branched or cyclic, and is preferably linear or branched. For example, methyl group, ethyl group, propyl group, isopropyl group, n-butyl group, sec-butyl group, tert-butyl group, isobutyl group, n-pentyl group, n-hexyl group, n-octyl group, n-decyl. Examples include a group and an n-dodecyl group. Of these, R is preferably a methyl group or an ethyl group.

n is an integer of 2 to 11, and among them, an integer of 2 to 9 is preferable, an integer of 2 to 7 is more preferable, and an integer of 2 to 5 is further preferable. Or 3, it is particularly preferable.

Examples of the polyoxyethylene monoalkyl ether represented by the general formula (1) include diethylene glycol monoethyl ether and triethylene glycol monoethyl ether. Of these, diethylene glycol monoethyl ether is preferable.

The method for producing the diester is not particularly limited as long as it is a method for esterifying a cyclohexanedicarboxylic acid and a polyoxyethylene monoalkyl ether represented by the general formula (1), and a known method can be adopted. For example, it can be produced by the method described in JP-A-2008-127342. In addition, a commercially available product can be used as the diester.

The content of the diester contained in the hair growth composition of the present invention is not particularly limited as long as it exerts an action of promoting the penetration of the active ingredient into the hair and skin. For example, for hair growth of the present invention. Based on the entire composition (100% by mass), about 0.1 to 10% by mass, preferably about 0.1 to 9% by mass, more preferably about 0.1 to 8% by mass, still more preferably 0.1. It is about 7% by mass, more preferably about 0.1 to 6% by mass, particularly preferably about 0.25 to 5% by mass, and most preferably about 0.5 to 5% by mass.

Further, in the hair-growth composition of the present invention, the mass ratio (C component / B component) of the diester which is the C component to the zinc compound which is the B component is preferably larger than 3, and more than 3 and 20 or less. More preferably, it is larger than 3 and 15 or less, more preferably 4 or more and 15 or less, and particularly preferably 5 or more and 15 or less. Although a limited interpretation is not desired, by setting the mass ratio of the C component to the B component within the above range, the cloudiness of the hair growth composition of the present invention can be further suppressed.

In addition to the above-mentioned A component, B component, and C component, the hair growth composition of the present invention can usually contain components that can be blended in the hair growth composition as long as the effects of the present invention are not impaired. For example, hair growth ingredients other than Ogon extract, surfactants, greasing agents, moisturizers, polymers, UV absorbers, metal sequestering agents, solvents, pH regulators, vitamins, antioxidants, antioxidant aids, Examples include preservatives, fragrances and cooling agents. These components may be used alone or in combination of two or more. Further, the content of these components in the hair-growth composition of the present invention is not particularly limited, and can be appropriately determined according to the blending purpose of the components.

The hair-growth component other than the ginger extract is not particularly limited as long as it has a hair-growth action, and known components can be used. For example, peripheral vasodilators, hair root activators, anti-inflammatory agents, sebum secretion inhibitors and the like can be mentioned.

Peripheral vasodilators include, for example, carpronium chloride, nicotinic acid derivatives (eg, benzyl nicotinate, nicotinamide, dl-α-tocopherol nicotinate, etc.), vitamin E derivatives (eg, dl-α-tocopherol, d- (Α-tocopherol, dl-α-tocopherol acetate, etc.), acetylcholine, diphenhydramine hydrochloride, garlic iodide extract, spironolactone, γ-orizanol, cepharanthin, nicotinil, minoxidil, diisopropylamine dichloroacetate, sembri extract, carrot extract, ginkgo extract, kina extract , Tohi extract, sophora extract and the like.

Examples of the hair root activator include mononitroguayacol sodium, placenta extract, N-acetyl-L-methionine, adenosine, adenine, adenosine triphosphate disodium, cepharanthin, potassium aspartate, pentadecanoic acid glyceride, pantothenic acid, and pantothenic acid. Examples include ethyl, panthenol, yeast extract, garlic extract, royal jelly and the like.

Examples of the anti-inflammatory agent include glycyrrhizic acid derivatives (dipotassium glycyrrhizinate, ammonium glycyrrhizinate, etc.), hydrocortisone acetate, azulene, guaiazulene, prednisolone, chamomile extract, kumazasa extract, and white birch extract.

Examples of the sebum secretion inhibitor include resorcin, pyridoxine hydrochloride, estradiol and the like.

Examples of the surfactant include anionic surfactants, cationic surfactants, amphoteric surfactants, lipophilic nonionic surfactants, and hydrophilic nonionic surfactants.

Examples of the anionic surfactant include higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate, alkyl ether sulfates such as POE-lauryl sulfate triethanolamine and POE-sodium lauryl sulfate, and sodium lauroyl sarcosin. Higher fatty acid amide sulfonates such as N-acylsarcosic acid, N-myristoyl-N-methyl taurine sodium, coconut oil fatty acid methyl taurid sodium, lauryl methyl taurid sodium, POE oleyl ether phosphate sodium, POE stearyl ether phosphoric acid Phosphate ester salts such as, di-2-ethylhexyl sulfosuccinate sodium, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate sodium, lauryl polypropylene glycol sulfosuccinate such as sodium sulfosuccinate, linadodecylbenzene sulfonate, linadodecylbenzene Alkylbenzene sulfonates such as triethanolamine sulfonate and dodecylbenzene sulfonic acid, monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, N-acylglutamate such as monosodium N-myristoyl-L-glutamate, hardened palm Higher fatty acid ester sulfates such as oil fatty acid glycyl sulfate sodium sulfate, POE-alkyl ether carboxylic acid, POE-alkylallyl ether carboxylate, α-olefin sulfonate, higher fatty acid ester sulfonate, secondary alcohol sulfate , Higher fatty acid alkylolamide sulfate ester salt, sodium lauroyl monoethanolamide succinate, ditriethanolamine N-palmitoyl aspartate, sodium caseinate and the like.

Examples of the cationic surfactant include a quaternary ammonium salt-type cationic surfactant, polychloride (N, N'-dimethyl-3,5-methylenepiperidinium), an alkylisoquinolinium salt, and a dialkylmori. Honium salt, POE-alkylamine, alkylamine salt, polyamine fatty acid derivative, amyl alcohol fatty acid derivative, benzalkonium chloride, benzethonium chloride and the like can be mentioned. Examples of the quaternary ammonium salt-type cationic surfactant include stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, behenyltrimethylammonium chloride, stearyltrimethylammonium bromide, distearyldimethylammonium chloride, and laurylbenzyldimethylammonium chloride. Can be mentioned.

Examples of the amphoteric tenside include an imidazoline-based amphoteric tenside such as 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazolin sodium, and 2-heptadecyl-N-carboxymethyl-N-. Examples thereof include betaine-based surfactants such as hydroxyethyl imidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amide betaine, and sulfobetaine.

Examples of the lipophilic nonionic surfactant include sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, and sorbitan monostearate, glycerin monoercaate, and sesquiolein. Examples thereof include glycerin fatty acids such as glycerin acid and glycerin monostearate, propylene glycol fatty acid esters such as propylene glycol monostearate, cured castor oil derivatives, and glycerin alkyl ethers.

Examples of the hydrophilic nonionic surfactant include POE sorbitan fatty acid esters such as POE-sorbitan monooleate and POE-sorbitan monostearate, and POE sorbit such as POE-sorbit monolaurate and POE-sorbit monooleate. POE-glycerin fatty acid esters such as fatty acid esters, POE-glycerin monostearate, POE-glycerin monoisostearate, POE-glycerin triisostearate, POE-monooleate, POE-distearate, POE-monodiolate and the like. POE-alkyl ethers such as fatty acid esters, POE-lauryl ethers, POE-oleyl ethers, POE-stearyl ethers, POE-behenyl ethers, POE-octylphenyl ethers, POE-nonylphenyl ethers, POE-dinonylphenyl ethers, etc. POE alkylphenyl ethers, pluronic types such as bluronic, POE / POP cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated lanolin, etc. -Alkyl ethers, tetra POE / tetra POP-ethylenediamine condensates such as Tetronic, POE-ice oil, POE-hardened bean oil, POE-hardened bean oil monoisostearate, etc. Derivatives, POE-Mitsurou lanolin derivatives such as POE-Sorbit Mitsurou, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, alkanolamide such as fatty acid isopropanolamide, POE-propylene glycol fatty acid ester, POE-alkylamine, POE-fatty acid Examples thereof include amides, sucrose fatty acid esters, POE-nonylphenylformaldehyde condensates, alkylethoxydimethylamine oxides and the like.

Examples of the greasing agent include fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, synthetic ester oils and the like.

Oils and fats include avocado oil, camellia oil, almond oil, macadamia nut oil, corn oil, grape seed oil, medfoam oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, wheat germ oil, southern ka oil, sunflower oil, and saflower. Oil, cotton seed oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, jojoba oil, germ oil, cacao butter, coconut oil, horse fat, hardened coconut oil, palm oil, beef fat, sheep fat, hardened beef fat, Examples include palm kernel oil, pork fat, mokuro kernel oil, and hardened castor oil.

Examples of waxes include beeswax, candelilla wax, cotton wax, carnauba wax, mokurou, baby wax, ibotarou, whale wax, montan wax, nukarou, lanolin, capoc wax, lanolin acetate, liquid lanolin, sugar cane, reduced lanolin, jojobaro, hard lanolin, and cellac wax. , POE lanolin alcohol ether and the like.

Examples of the hydrocarbon include liquid paraffin, ozokerite, squalene, paraffin, selecin, petrolatum, microcrystalline wax and the like.

Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic (behenic acid) acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall acid, isostearic acid, linoleic acid, linoleic acid, and d. Examples thereof include icosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

Examples of higher alcohols include linear alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol, monostearyl glycerin ether (bacyl alcohol), 2-decyltetradecinol, and lanolin. Examples thereof include branched alcohols such as alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol and octyldodecanol.

Synthetic ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate. , Lanolin acetate, Isocetyl stearate, Isocetyl isostearate, Ethylene glycol di-2-ethylhexylate, Dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, Neopentyl glycol dicaprate, Diisostearyl malate, Di-2 -Glycerin heptylundecanoate, trimethylol propane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, glycerin tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2- Ethylhexanoate, 2-ethylhexyl palmitate, glycerin trimyristate, glyceride tri-2-heptylundecanoic acid, methyl ester of castor oil fatty acid, oleic acid oil, cetostearyl alcohol, acetoglyceride, 2-heptyl undesyl palmitate, Diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundesyl adipate, ethyllaurate, di-2-ethylhexyl sebatate, 2-hexyldecyl myristate, palmitate 2 -Hexyldecyl, 2-hexyldecyl adipate, diisopropyl sebatate, 2-ethylhexyl succinate, glycerin trioctanoate, glycerin triisopalmitate, laminolin fatty acid isopropyl, hexyl laurate and the like can be mentioned.

Examples of the hair protective agent include chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane, and cyclic polys such as decamethylpolysiloxane, dodecamethylpolysiloxane, and tetramethyltetrahydrogenpolysiloxane. Examples thereof include siloxane and silicone resin.

Moisturizers include, for example, polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, sorbitol, martitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch-degrading sugar, maltose, xylitol, etc. Sugar alcohols such as starch-degrading sugar-reduced alcohol, amino acids, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, collagen derivatives, cholesteryl-12-hydroxystearate, sodium lactate, bile salt, seawater (including dry matter), ocean Examples thereof include deep water (including dry matter), chitosan derivatives, sodium pyrrolidone carboxylate, diglycerin / ethylene oxide / propylene oxide adducts and the like.

Examples of the polymer include a natural water-soluble polymer, a semi-synthetic water-soluble polymer, a synthetic water-soluble polymer, and an inorganic water-based polymer.

Natural water-soluble polymers include, for example, alaabia gum, tragacant gum, galactan, guagam, carob gum, karaya gum, carrageenan, pectin, canten, quince seed (malmero), algae colloid (cassaw extract), starch (rice, corn, potato, wheat). ) And other plant-based polymers, dextran, succinoglucan, purulan and other microbial-based polymers, and casein, albumin, gelatin and other animal-based polymers.

Examples of the semi-synthetic water-soluble polymer include starch-based polymers such as carboxymethyl starch and methyl hydroxypropyl starch, methyl cellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, cellulose cellulose sulfate, hydroxypropyl cellulose, and sodium carboxymethyl cellulose. Examples thereof include cellulosic polymers such as (CMC), crystalline cellulose and cellulosic powder, and alginate polymers such as sodium alginate and propylene glycol alginate.

Examples of the synthetic water-soluble polymer include vinyl-based polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, and carboxyvinyl polymer, and polyoxyethylene-based polymers such as polyethylene glycol 20,000, 40,000, and 60,000. Examples thereof include polymers, copolymer-based polymers such as polyoxyethylene polyoxypropylene copolymers, acrylic polymers such as sodium polyacrylate, polyethyl acrylate and polyacrylamide, polyethyleneimine, and cationized polymers.

Examples of the inorganic aqueous polymer include bentonite, magnesium aluminum silicate (beagum), laponite, hectorite, and silicic anhydride.

Examples of the ultraviolet absorber include paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, 4- [N, N-di (2-hydroxypropyl)). Amino] Benzophenone-based UV absorbers such as ethyl benzoate, anthranylic acid-based UV absorbers such as homomentyl-N-acetylanthranilate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, p-tert-butyl salicylate Salicylic acid-based ultraviolet absorbers such as phenyl and homomentyl salicylate, benzyl laurate, 2-ethoxyethyl paramethoxycinerate, octyl paramethoxycinerate, mono-2-ethylhexylhexanate diparamethoxy, glyceryl hexylhexanate, isopropyl diisopropyl silicate. Ceramic acid-based UV absorbers such as mixtures, urocanic acid-based UV absorbers such as urocanic acid and ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid, sodium hydroxymethoxybenzophenone sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone disulfone Benzophenone-based ultraviolet absorbers such as sodium acid, dihydroxybenzophenone, and tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxy-dibenzoylmethane, 2,4,6-trianilino-p- (carbo-2'-ethylhexyl-) Examples thereof include 1'-oxy) -1,3,5-triazine and 2- (2-hydroxy-5-methylphenyl) benzotriazole.

Examples of the metal sequestering agent include alanine, ethylenediaminehydroxyethyl trisodium triacetate, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, tartaric acid, and the like. Examples thereof include succinic acid, edetolic acid, and phytic acid.

Examples of the solvent include lower alcohols such as methanol, propanol, isopropanol, isobutyl alcohol, and t-butyl alcohol, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butyleneglucol, 1,3-butyleneglucol, and the like. Divalent alcohols such as glycerin, trimethylolpropane, trihydric alcohols such as 1,2,6-hexanetriol, tetrahydric alcohols such as pentaerythritol, pentahydric alcohols such as xylitol, hexavalents such as sorbitol and mannitol. Alcohol, diethylene glycol, dipropylene glycol, triethylene glucol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerin and other polyhydric alcohol polymers, ethylene glycol monomethyl ether and other divalent Alcohol alkyl ethers, diethylene glycol monomethyl ethers, dihydric alcohol alkyl ethers such as diethylene glycol monoethyl ethers, dihydric alcohol ether esters such as ethylene glycol monomethyl ether acetate, glycerin monoalkyls such as xyl alcohol, seraquil alcohol, and batyl alcohol. Examples include ether.

Examples of the pH adjuster include citric acid, lactic acid, acetic acid, hydrochloric acid, potassium hydroxide, sodium hydroxide, sodium lactate, sodium citrate, sodium lactate and the like. These can be used alone or in combination, and can be used not only for adjusting the pH value but also for buffering the adjusted pH value.

Examples of vitamins include vitamins A, B1, B2, B6, E and their derivatives, pantothenic acid and its derivatives, and the like.

Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters and the like.

Examples of preservatives include organic acids such as benzoic acid, sodium benzoate, undecyleneic acid, salicylic acid, sorbic acid and paraoxybenzoate and their derivatives, phenols such as isopropylmethylphenol, phenoxyethanol and 1,2-hexanediol. , 1,2-Pentanediol and the like.

Examples of the refreshing agent include l-menthol, menthyl lactate, 3- (menthyloxy) propane-1,2-diol and the like.

The form of the hair-growth composition of the present invention is not particularly limited as long as it is used as the hair-growth composition, and is not limited to liquid dosage forms such as aqueous solutions (water types), lotions, and creams. It may be in the form of a gel, a paste, a solid stick, a powder, a granule, or the like.

In addition, the hair-growth composition of the present invention can be used by contacting the hair or the scalp. The method of contacting the hair is not particularly limited, and examples thereof include a method of applying to the hair and a method of spraying on the hair or the scalp.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples.

Production Example: Preparation of Hair Growth Composition A hair growth composition was prepared by mixing each component in the blending amounts shown in Examples 1 to 6 and Comparative Examples 1 to 5 in Table 1 below.

Test Example: Examination of Transparency The hair growth compositions of Examples 1 to 6 and Comparative Examples 1 to 5 prepared in the above production examples were left to stand for 2 months at -5 ° C, 25 ° C, and 40 ° C, respectively. The state of each hair growth composition after being left for 2 months was visually confirmed, and the transparency was evaluated according to the following criteria. The results are shown in the "State after leaving for 2 months" column in Table 1 below.

◯: No turbidity was confirmed.
Δ: Slight turbidity was confirmed.
X: White turbidity was confirmed.

In addition, photographs of the hair-growth compositions of Examples 1 to 6 and Comparative Examples 1 to 5 after being left for 2 months are shown in FIG. In addition, in FIG. 1, it corresponds to Examples 1 to 6 and Comparative Examples 1 to 5 in order from the left.

Then, after being left to stand for another month under the same conditions as above, the transmittance at a wavelength of 500 nm (unit:%, optical path length: 1 cm, temperature 25) was used using an ultraviolet visible spectrophotometer (UV-2600, manufactured by Shimadzu Corporation). ℃) was measured. The results are shown in the "Transmittance (%)" column of Table 1 below.

In the hair-growth compositions containing eugon extract and zinc gluconate (Comparative Examples 4 and 5), remarkable cloudiness was confirmed, whereas in addition to eugon extract and zinc gluconate, bisethoxydiglycolcyclohexanedicarboxylic acid was added. No cloudiness was confirmed in the hair-growth composition containing (Examples 1 to 5). In addition, no cloudiness was confirmed in the hair-growth composition (Comparative Examples 1 to 3) containing the augon extract and the bisethoxydiglycol cyclohexanedicarboxylic acid. From the above results, it was found that the combination of the augon extract and zinc gluconate causes white turbidity, and the use of bisethoxydiglycol cyclohexanedicarboxylic acid does not cause white turbidity.

Further, among Examples 1 to 5, in Examples 3, 5 and 6, a slight turbidity was confirmed when left at 40 ° C, whereas in Examples 1, 2 and 4, left at 40 ° C. No cloudiness was confirmed even in the case of. From the above results, it was found that the turbidity of the composition can be further suppressed by setting the ratio of bisethoxydiglycolcyclohexanedicarboxylic acid to zinc gluconate within a specific range (specifically, a value larger than 3). It was.

Claims (3)

(A): Ogon extract,
(B): Zinc gluconate and (C): Bisethoxydiglycol cyclohexanedicarboxylic acid.
The mass ratio of the C component to the B component (C component / B component) is larger than 3.
Composition for hair growth. The hair-growth composition according to claim 1, wherein the B component is contained in an amount of 0.1 to 3 % by mass, and the C component is contained in an amount of more than 0.3% by mass and 10% by mass or less . The hair-growth composition according to claim 1 or 2, which contains 0.1 to 10% by mass of the component A.