JP6774690B1 - Antiviral alloy - Google Patents

Antiviral alloy Download PDF

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JP6774690B1
JP6774690B1 JP2019165563A JP2019165563A JP6774690B1 JP 6774690 B1 JP6774690 B1 JP 6774690B1 JP 2019165563 A JP2019165563 A JP 2019165563A JP 2019165563 A JP2019165563 A JP 2019165563A JP 6774690 B1 JP6774690 B1 JP 6774690B1
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JP2021042438A (en
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康弘 和気
康弘 和気
基文 手塚
基文 手塚
裕稀 松前
裕稀 松前
昭孔 矢次
昭孔 矢次
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Aida Chemical Industries Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • CCHEMISTRY; METALLURGY
    • C22METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22CALLOYS
    • C22C5/00Alloys based on noble metals
    • C22C5/06Alloys based on silver

Abstract

【課題】抗ウイルス性を有する合金を提供する。【解決手段】抗ウイルス性を有する合金であって、2.5重量%から10.0重量%の錫(Sn)と、0.01重量%から1.0重量%の金(Au)とが含まれ、残部が銀(Ag)で構成される。【選択図】なしPROBLEM TO BE SOLVED: To provide an alloy having antiviral property. An alloy having antiviral properties, consisting of 2.5% by weight to 10.0% by weight of tin (Sn) and 0.01% by weight to 1.0% by weight of gold (Au). Included, the balance is composed of silver (Ag). [Selection diagram] None

Description

従来、合金は、優れた加工特性を有するため、装飾品や金属材料に使用されてきた。例えば、銀−銅合金粉末と有機系バインダとを含有した装飾用の銀含有可塑性組成物としても使用されている(例えば、特許文献1)。
また、銀が含有された合金や化合物は、抗菌性や抗ウイルス性を有するため、医療の現場で使用される金属材料や衛生用品にも使用されている(例えば、特許文献2、及び特許文献3)。
Traditionally, alloys have been used in ornaments and metal materials due to their excellent processing properties. For example, it is also used as a decorative silver-containing plastic composition containing a silver-copper alloy powder and an organic binder (for example, Patent Document 1).
In addition, since silver-containing alloys and compounds have antibacterial and antiviral properties, they are also used in metal materials and sanitary products used in the medical field (for example, Patent Document 2 and Patent Documents). 3).

特開2018−24926号公報Japanese Unexamined Patent Publication No. 2018-24926 特表平9−510629号公報Special Table No. 9-510629 特許第5291198号公報Japanese Patent No. 5291198

これまで開示されている抗ウイルス性を有する銀合金は、含有させる金属の種類が多く、
例えば、ニッケル(Ni)は、特に強い金属アレルギーを引き起こす原因となり、鉛(Pb)は、有害物質であるため、人の肌に直接触れる用途に使用することは困難である。
そのため、人の肌に触れる場所や物に適用できる、汎用性の高い抗ウイルス性を有する合金が求められている。
The silver alloys having antiviral properties disclosed so far contain many types of metals.
For example, nickel (Ni) causes a particularly strong metal allergy, and lead (Pb) is a toxic substance, so it is difficult to use it for applications that come into direct contact with human skin.
Therefore, there is a demand for a highly versatile antiviral alloy that can be applied to places and objects that come into contact with human skin.

そこで、本発明は、抗ウイルス性を有する合金を提供することを目的とする。 Therefore, an object of the present invention is to provide an alloy having antiviral properties.

本発明の合金は、抗ウイルス性を有し、2.5重量%から10.0重量%の錫(Sn)と、0.01重量%から1.0重量%の金(Au)とが含まれ、残部が銀(Ag)で構成されることを特徴とする。 The alloy of the present invention is antiviral and contains 2.5% to 10.0% by weight tin (Sn) and 0.01% to 1.0% by weight gold (Au). It is characterized in that the balance is composed of silver (Ag).

本発明の合金は、錫(Sn)が3.95重量%以上含まれていることが好ましい。 The alloy of the present invention preferably contains tin (Sn) in an amount of 3.95% by weight or more.

本発明に係る合金は、2.5重量%から10.0重量%の錫(Sn)と、0.01重量%から1.0重量%の金(Au)とが含まれ、残部が銀(Ag)で構成されている。
上記の濃度で金属が含有された合金は、純銀(銀100%)よりも高い抗ウイルス性を示すと共に、加工性にも優れ、極めて実用的価値が高い。そのため、医療分野や食品分野などの抗ウイルス性を強く求められる材料に応用することができる。
The alloy according to the present invention contains 2.5% by weight to 10.0% by weight of tin (Sn) and 0.01% by weight to 1.0% by weight of gold (Au), with the balance being silver (s). It is composed of Ag).
Alloys containing metals at the above concentrations exhibit higher antiviral properties than pure silver (100% silver), are also excellent in processability, and have extremely high practical value. Therefore, it can be applied to materials strongly required to have antiviral properties such as medical fields and food fields.

本実施形態に係る合金について、説明する。
本実施形態に係る合金は、銀(Ag)、錫(Sn)、及び金(Au)を含んでいる。これらの合金は、錫(Sn)が2.5重量%から10.0重量%、金(Au)が0.01重量%から1.0重量%がそれぞれ含まれ、残部が銀(Ag)で構成されている。
The alloy according to this embodiment will be described.
The alloy according to this embodiment contains silver (Ag), tin (Sn), and gold (Au). These alloys contain 2.5% to 10.0% by weight of tin (Sn), 0.01% to 1.0% by weight of gold (Au), and the balance is silver (Ag). It is configured.

本実施形態では、表1に示した濃度で合金を作製し(実施例1から実施例7、及び比較例1から比較例14)、これらの合金の抗ウイルス性を調べた。 In this embodiment, alloys were prepared at the concentrations shown in Table 1 (Examples 1 to 7 and Comparative Examples 1 to 14), and the antiviral properties of these alloys were examined.

実施例1から実施例7の合金の組成は、以下の通りである。
[実施例1]:銀(Ag)(97.0重量%)、錫(Sn)(2.90重量%)、金(Au)(0.10重量%)
[実施例2]:銀(Ag)(95.05重量%)、錫(Sn)(3.95重量%)、金(Au)(1.00重量%)
[実施例3]:銀(Ag)(95.50重量%)、錫(Sn)(3.95重量%)、金(Au)(0.55重量%)
[実施例4]:銀(Ag)(95.95重量%)、錫(Sn)(3.95重量%)、金(Au)(0.10重量%)
[実施例5]:銀(Ag)(96.04重量%)、錫(Sn)(3.95重量%)、金(Au)(0.01重量%)
[実施例6]:銀(Ag)(92.50重量%)、錫(Sn)(7.40重量%)、金(Au)(0.10重量%)
[実施例7]:銀(Ag)(90.00重量%)、錫(Sn)(9.90重量%)、金(Au)(0.10重量%)
The composition of the alloys of Examples 1 to 7 is as follows.
[Example 1]: Silver (Ag) (97.0% by weight), Tin (Sn) (2.90% by weight), Gold (Au) (0.10% by weight)
[Example 2]: Silver (Ag) (95.05% by weight), Tin (Sn) (3.95% by weight), Gold (Au) (1.00% by weight)
[Example 3]: Silver (Ag) (95.50% by weight), Tin (Sn) (3.95% by weight), Gold (Au) (0.55% by weight)
[Example 4]: Silver (Ag) (95.95% by weight), Tin (Sn) (3.95% by weight), Gold (Au) (0.10% by weight)
[Example 5]: Silver (Ag) (96.04% by weight), Tin (Sn) (3.95% by weight), Gold (Au) (0.01% by weight)
[Example 6]: Silver (Ag) (92.50% by weight), Tin (Sn) (7.40% by weight), Gold (Au) (0.10% by weight)
[Example 7]: Silver (Ag) (90.00% by weight), Tin (Sn) (9.90% by weight), Gold (Au) (0.10% by weight)

比較例1から比較例14として、以下の合金を作製した。比較例8から比較例11、比較例13、比較例14は、金(Au)を含まない合金、比較例12から比較例14では、錫(Sn)を含まない合金とした。そして、比較例9及び比較例13は、ゲルマニウム(Ge)、比較例10及び比較例14では銅(Cu)をそれぞれ含有させた合金とした。 The following alloys were produced as Comparative Examples 1 to 14. Comparative Examples 8 to 11, Comparative Example 13, and Comparative Example 14 were alloys containing no gold (Au), and Comparative Examples 12 to 14 were alloys containing no tin (Sn). Then, Comparative Example 9 and Comparative Example 13 were alloys containing germanium (Ge), and Comparative Example 10 and Comparative Example 14 were alloys containing copper (Cu), respectively.

[比較例1]:銀(Ag)(96.049重量%)、錫(Sn)(3.95重量%)、金(Au)(0.001重量%)
[比較例2]:銀(Ag)(99.0重量%)、錫(Sn)(0.90重量%)、金(Au)(0.10重量%)
[比較例3]:銀(Ag)(99.50重量%)、錫(Sn)(0.40重量%)、金(Au)(0.10重量%)
[比較例4]:銀(Ag)(80.00重量%)、錫(Sn)(19.90重量%)、金(Au)(0.10重量%)
[比較例5]:銀(Ag)(50.00重量%)、錫(Sn)(49.90重量%)、金(Au)(0.10重量%)
[比較例6]:銀(Ag)(9.90重量%)、錫(Sn)(90.00重量%)、金(Au)(0.10重量%)
[比較例7]:銀(Ag)(0.40重量%)、錫(Sn)(99.50重量%)、金(Au)(0.10重量%)
[比較例8]:銀(Ag)(96.05重量%)、錫(Sn)(3.95重量%)
[比較例9]:銀(Ag)(95.50重量%)、錫(Sn)(3.95重量%)、ゲルマニウム(Ge)(0.55重量%)
[比較例10]:銀(Ag)(95.50重量%)、錫(Sn)(3.95重量%)、銅(Cu)(0.55重量%)
[比較例11]:銀(Ag)(95.50重量%)、錫(Sn)(4.50重量%)
[比較例12]:銀(Ag)(95.50重量%)、金(Au)(4.50重量%)
[比較例13]:銀(Ag)(95.50重量%)、ゲルマニウム(Ge)(4.50重量%)[比較例14]:銀(Ag)(95.50重量%)、銅(Cu)(4.50重量%)
[比較例15]:銀(Ag)(100重量%)
[Comparative Example 1]: Silver (Ag) (96.049% by weight), Tin (Sn) (3.95% by weight), Gold (Au) (0.001% by weight)
[Comparative Example 2]: Silver (Ag) (99.0% by weight), Tin (Sn) (0.90% by weight), Gold (Au) (0.10% by weight)
[Comparative Example 3]: Silver (Ag) (99.50% by weight), Tin (Sn) (0.40% by weight), Gold (Au) (0.10% by weight)
[Comparative Example 4]: Silver (Ag) (80.00% by weight), Tin (Sn) (19.90% by weight), Gold (Au) (0.10% by weight)
[Comparative Example 5]: Silver (Ag) (50.00% by weight), Tin (Sn) (49.90% by weight), Gold (Au) (0.10% by weight)
[Comparative Example 6]: Silver (Ag) (9.90% by weight), Tin (Sn) (90.00% by weight), Gold (Au) (0.10% by weight)
[Comparative Example 7]: Silver (Ag) (0.40% by weight), Tin (Sn) (99.50% by weight), Gold (Au) (0.10% by weight)
[Comparative Example 8]: Silver (Ag) (96.05% by weight), Tin (Sn) (3.95% by weight)
[Comparative Example 9]: Silver (Ag) (95.50% by weight), Tin (Sn) (3.95% by weight), Germanium (Ge) (0.55% by weight)
[Comparative Example 10]: Silver (Ag) (95.50% by weight), Tin (Sn) (3.95% by weight), Copper (Cu) (0.55% by weight)
[Comparative Example 11]: Silver (Ag) (95.50% by weight), Tin (Sn) (4.50% by weight)
[Comparative Example 12]: Silver (Ag) (95.50% by weight), Gold (Au) (4.50% by weight)
[Comparative Example 13]: Silver (Ag) (95.50% by weight), Germanium (Ge) (4.50% by weight) [Comparative Example 14]: Silver (Ag) (95.50% by weight), Copper (Cu) ) (4.50% by weight)
[Comparative Example 15]: Silver (Ag) (100% by weight)

各合金の抗ウイルス性試験を以下の通り行った。
具体的には、各合金(35mm×35mm×厚さ1mm)をバクテリオファージφ6(抗インフルエンザ代替ウイルス)希釈液(1/4NB)に、室温下で、5分間浸漬させた後、抗ウイルス性を調べた。抗ウイルス性試験は、JIS R1756(2013(可視光応答型光触媒、抗ウイルス(バクテリオファージ)))を参考に行った。なお、密着フィルムには、ポリプロピレンフィルム(30mm×30mm)を使用した。
試験後、抗ウイルス活性値を比較することで、評価した。抗ウイルス活性値は以下の式によって計算した。
V=U−A
V:抗ウイルス活性値
:接種量あたりのバクテリオファージの感染価の対数値
:試料の反応後の感染価の対数値
The antiviral test of each alloy was performed as follows.
Specifically, each alloy (35 mm × 35 mm × thickness 1 mm) is immersed in a bacteriophage φ6 (anti-influenza substitute virus) diluted solution (1/4 NB) at room temperature for 5 minutes, and then has antiviral properties. Examined. The antiviral test was carried out with reference to JIS R1756 (2013 (visible light responsive photocatalyst, antiviral (bacteriophage))). A polypropylene film (30 mm × 30 mm) was used as the adhesion film.
After the test, it was evaluated by comparing the antiviral activity values. The antiviral activity value was calculated by the following formula.
V = U 0 -A t
V: Antiviral activity value U 0: infectivity logarithm A t of bacteriophage per inoculum: Infectivity logarithm after reaction of the sample

評価基準は以下の通りとした。
◎:抗ウイルス活性値5.3以上
〇:抗ウイルス活性値2.5以上5.3未満
△:抗ウイルス活性値1.0以上2.5未満
×:抗ウイルス活性値1.0未満
The evaluation criteria are as follows.
⊚: Antiviral activity value 5.3 or more 〇: Antiviral activity value 2.5 or more and less than 5.3 Δ: Antiviral activity value 1.0 or more and less than 2.5 ×: Antiviral activity value less than 1.0

Figure 0006774690
Figure 0006774690

各合金の抗ウイルス性試験の結果を表1に示した。
実施例2から実施例7に係る合金は、非常に高い抗ウイルス性を示し、実施例1の合金はやや高い抗ウイルス性を示すことがわかった。このことから、これらの合金は、バクテリオファージφ6を不活性化させる特性を有することがわかった。そして、これら実施例1から実施例7の合金は全て、比較例15(純銀)よりも高い抗ウイルス性を示すことも明らかとなった。
また、実施例1から実施例7に係る合金は、加工性にも優れていることがわかった。
The results of the antiviral test of each alloy are shown in Table 1.
It was found that the alloys of Examples 2 to 7 showed very high antiviral properties, and the alloys of Example 1 showed slightly high antiviral properties. From this, it was found that these alloys have the property of inactivating the bacteriophage φ6. It was also revealed that all of the alloys of Examples 1 to 7 exhibited higher antiviral properties than Comparative Example 15 (pure silver).
Further, it was found that the alloys according to Examples 1 to 7 were also excellent in workability.

まず、錫(Sn)を含有させた効果について説明する。
実施例1から実施例7と比較例12(錫(Sn)不含有)、比較例13(錫(Sn)の代わりにゲルマニウム(Ge)を含有)及び比較例14(錫(Sn)の代わりに銅(Cu)を含有う)の結果を比較すると、錫(Sn)を含有させた合金が高い抗ウイルス性を有していることがわかった。実施例1から実施例7に係る合金において、錫(Sn)が3.95重量%以上含有されていることで、特に高い抗ウイルス性を示すことがわかった。
また、比較例2から比較例7の結果から、錫(Sn)の濃度が2.5重量%から10.0重量%の範囲外の合金では、抗ウイルス性が低い、あるいは、所望の形状に加工ができないことがわかった。
First, the effect of containing tin (Sn) will be described.
Examples 1 to 7 and Comparative Example 12 (without tin (Sn)), Comparative Example 13 (containing germanium (Ge) instead of tin (Sn)), and Comparative Example 14 (instead of tin (Sn)). Comparing the results of copper (Cu) contained), it was found that the tin (Sn) -containing alloy has high antiviral properties. It was found that the alloys according to Examples 1 to 7 exhibited particularly high antiviral properties when tin (Sn) was contained in an amount of 3.95% by weight or more.
Further, from the results of Comparative Examples 2 to 7, alloys having a tin (Sn) concentration outside the range of 2.5% by weight to 10.0% by weight have low antiviral properties or have a desired shape. It turned out that it could not be processed.

次に、金(Au)を含有させた効果について説明する。
実施例2と比較例8(金(Au)不含有)及び比較例9(金(Au)の代わりにゲルマニウム(Ge)を含有)の結果を比較すると、金(Au)を含有させた合金が高い抗ウイルス性を有していることが明らかである。さらに比較例1(金(Au):0.001重量%)の結果から、金(Au)を0.10重量%以上含有させることで、高い抗ウイルス性を付与できると考えられる。ただし、金(Au)は高価であるため、1.00重量%以下であることが好ましい。
なお、比較例11(金(Au)不含有)と比較例12(錫(Sn)不含有)の結果から、同じ濃度であれば、金(Au)を含有させた合金の方が錫(Sn)を含有させた合金よりも、高い抗ウイルス性を示すことがわかる。
Next, the effect of containing gold (Au) will be described.
Comparing the results of Example 2 with Comparative Example 8 (without gold (Au)) and Comparative Example 9 (containing germanium (Ge) instead of gold (Au)), the alloy containing gold (Au) was found. It is clear that it has high antiviral properties. Further, from the result of Comparative Example 1 (gold (Au): 0.001% by weight), it is considered that high antiviral property can be imparted by containing 0.10% by weight or more of gold (Au). However, since gold (Au) is expensive, it is preferably 1.00% by weight or less.
From the results of Comparative Example 11 (without gold (Au)) and Comparative Example 12 (without tin (Sn)), the alloy containing gold (Au) is more tin (Sn) at the same concentration. It can be seen that it exhibits higher antiviral properties than the alloy containing).

以上の結果から、銀(Ag)−錫(Sn)−金(Au)合金とし、錫(Sn)が2.5重量%から10.0重量%、金(Au)が0.01重量%から1.0重量%がそれぞれ含まれていることで、高い抗ウイルス性を示すことがわかった。さらに、これらの合金は、純銀よりも高い抗ウイルス性を示すことも明らかとなった。 From the above results, a silver (Ag) -tin (Sn) -gold (Au) alloy is used, with tin (Sn) from 2.5% by weight to 10.0% by weight and gold (Au) from 0.01% by weight. It was found that a high antiviral property was exhibited by containing 1.0% by weight of each. Furthermore, it was revealed that these alloys show higher antiviral properties than sterling silver.

また、本実施形態の銀(Ag)−錫(Sn)−金(Au)合金は、抗ウイルス性を有することに加え、加工性にも優れているため、医療分野(例えば、ドアハンドル、医療用メス、医療用ピンセット、医療用バット、回診車)、食品分野(例えば、トング、食器、厨房機器)、日用品分野(例えば、つめきり、毛抜き、耳かき)、住宅関連分野(例えば、三角コーナー、排水口、洗面台、シンク)、家電分野(例えば、空気清浄機フィルター、エアコンフィルター、掃除機)、機械設備関連分野(例えば、ボルト、ねじ)、及び畜産関連分野(防鳥ネット、床、壁)に応用することができる。 Further, since the silver (Ag) -tin (Sn) -gold (Au) alloy of the present embodiment has excellent processability in addition to having antiviral properties, it is excellent in the medical field (for example, door handle, medical treatment). Medical scalpels, medical tweezers, medical bats, round-trip cars), food fields (eg tongs, tableware, kitchen equipment), daily necessities fields (eg claws, hair removers, ear cleaners), housing related fields (eg triangular corners, drainage) Mouth, wash basin, sink), household appliances (eg air purifier filter, air conditioner filter, vacuum cleaner), machinery related fields (eg bolts, screws), and livestock related fields (bird nets, floors, walls) Can be applied to.

さらに、本実施形態の銀(Ag)−錫(Sn)−金(Au)合金は、例えば、スパッタリング法、真空蒸着法、イオンプレーティング法で使用する薄膜形成用ターゲット材として使用し、物(材料)の表面にこれらの合金を被膜させることもできる。このように、物の表面に合金の薄膜を形成することで、抗ウイルス性を付与することができる。 Further, the silver (Ag) -tin (Sn) -gold (Au) alloy of the present embodiment is used as a target material for thin film formation used in, for example, a sputtering method, a vacuum deposition method, and an ion plating method. The surface of the material) can also be coated with these alloys. By forming an alloy thin film on the surface of an object in this way, antiviral properties can be imparted.

以上、本実施形態について説明したが、これ以外にも、本発明の主旨を逸脱しない限り、上記実施の形態で挙げた構成を取捨選択したり、他の構成に適宜変更することが可能である。本実施形態では、抗ウイルス性について調べたが、本実施形態に係る合金は、抗菌性も有すると考えられる。
本実施形態に係る合金には、銀よりも標準電極電位が高い金(Au)を用いたが、金(Au)以外の金属として、パラジウム(Pd)、イリジウム(Ir)、白金(Pt)、ルテニウム(Ru)、ロジウム(Rh)を用いることもできる。また、本実施形態に係る合金には、錫(Sn)を用いたが、錫(Sn)以外の金属として、亜鉛(Zn)、ガリウム(Ga)、アルミニウム(Al)、ビスマス(Bi)、アンチモン(Sb)、インジウム(In)を用いることもできる。
Although the present embodiment has been described above, other than this, the configuration described in the above embodiment can be selected or changed as appropriate without departing from the gist of the present invention. .. In this embodiment, the antiviral property has been investigated, but it is considered that the alloy according to the present embodiment also has antibacterial property.
Gold (Au), which has a higher standard electrode potential than silver, was used as the alloy according to the present embodiment, but palladium (Pd), iridium (Ir), platinum (Pt), and other metals other than gold (Au) were used. Ruthenium (Ru) and rhodium (Rh) can also be used. Further, although tin (Sn) was used as the alloy according to the present embodiment, as metals other than tin (Sn), zinc (Zn), gallium (Ga), aluminum (Al), bismuth (Bi), and antimony were used. (Sb) and indium (In) can also be used.

Claims (2)

抗ウイルス性を有する合金から成る抗ウイルス性部材であって、
2.5重量%から10.0重量%の錫(Sn)と、
0.01重量%から1.0重量%の金(Au)と、が含まれ、
残部が銀(Ag)で構成される、
ことを特徴とする合金から成る抗ウイルス性部材
An antiviral member made of an alloy having antiviral properties.
From 2.5% to 10.0% by weight of tin (Sn),
Contains 0.01% to 1.0% by weight of gold (Au),
The rest is made of silver (Ag),
An antiviral member made of an alloy.
前記錫(Sn)が3.95重量%以上含まれている、
請求項1に記載の合金から成る抗ウイルス性部材
The tin (Sn) is contained in an amount of 3.95% by weight or more.
An antiviral member made of the alloy according to claim 1.
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JP7440153B1 (en) 2023-09-19 2024-02-28 相田化学工業株式会社 Antiviral alloys and antiviral components

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US5681575A (en) * 1992-05-19 1997-10-28 Westaim Technologies Inc. Anti-microbial coating for medical devices
JPH09111378A (en) * 1995-10-18 1997-04-28 Nisshin Steel Co Ltd Ag-cu-sn alloy excellent in antibacterial and antimold property
JP4714477B2 (en) * 2004-02-19 2011-06-29 アルバック成膜株式会社 Ag alloy film and manufacturing method thereof

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