JP6771467B2 - 熱安定性が改善された吸収性コポリマー - Google Patents

熱安定性が改善された吸収性コポリマー Download PDF

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JP6771467B2
JP6771467B2 JP2017533270A JP2017533270A JP6771467B2 JP 6771467 B2 JP6771467 B2 JP 6771467B2 JP 2017533270 A JP2017533270 A JP 2017533270A JP 2017533270 A JP2017533270 A JP 2017533270A JP 6771467 B2 JP6771467 B2 JP 6771467B2
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prepolymer
glycolide
polymer
copolymer
lactide
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JP2018501368A (ja
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ケネス デイヴィッド グレイ
ケネス デイヴィッド グレイ
マイケル アーロン ヴォーン
マイケル アーロン ヴォーン
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ポリ−メッド インコーポレイテッド
ポリ−メッド インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • C08G63/82—Preparation processes characterised by the catalyst used
    • C08G63/85—Germanium, tin, lead, arsenic, antimony, bismuth, titanium, zirconium, hafnium, vanadium, niobium, tantalum, or compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Artificial Filaments (AREA)
  • Biological Depolymerization Polymers (AREA)
JP2017533270A 2014-12-19 2015-12-18 熱安定性が改善された吸収性コポリマー Active JP6771467B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462094723P 2014-12-19 2014-12-19
US62/094,723 2014-12-19
PCT/US2015/066869 WO2016100915A2 (en) 2014-12-19 2015-12-18 Absorbable copolymers with improved thermal stability

Related Child Applications (1)

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JP2020162888A Division JP7165172B2 (ja) 2014-12-19 2020-09-29 熱安定性が改善された吸収性コポリマー

Publications (2)

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JP2018501368A JP2018501368A (ja) 2018-01-18
JP6771467B2 true JP6771467B2 (ja) 2020-10-21

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JP2017533270A Active JP6771467B2 (ja) 2014-12-19 2015-12-18 熱安定性が改善された吸収性コポリマー
JP2020162888A Active JP7165172B2 (ja) 2014-12-19 2020-09-29 熱安定性が改善された吸収性コポリマー
JP2022168963A Active JP7549632B2 (ja) 2014-12-19 2022-10-21 熱安定性が改善された吸収性コポリマー
JP2024148586A Pending JP2025010531A (ja) 2014-12-19 2024-08-30 熱安定性が改善された吸収性コポリマー

Family Applications After (3)

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JP2020162888A Active JP7165172B2 (ja) 2014-12-19 2020-09-29 熱安定性が改善された吸収性コポリマー
JP2022168963A Active JP7549632B2 (ja) 2014-12-19 2022-10-21 熱安定性が改善された吸収性コポリマー
JP2024148586A Pending JP2025010531A (ja) 2014-12-19 2024-08-30 熱安定性が改善された吸収性コポリマー

Country Status (4)

Country Link
US (3) US20160177026A1 (https=)
EP (2) EP3233963B1 (https=)
JP (4) JP6771467B2 (https=)
WO (1) WO2016100915A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019046808A1 (en) * 2017-09-01 2019-03-07 Poly-Med, Inc. POLYMERS FOR ADDITIVE MANUFACTURE
CA3096216A1 (en) 2018-04-06 2019-10-10 Poly-Med, Inc. Methods and compositions for photopolymerizable additive manufacturing
US11639416B2 (en) 2018-04-19 2023-05-02 Poly-Med, Inc. Macromers and compositions for photocuring processes
CN117468113A (zh) * 2019-03-06 2024-01-30 聚合-医药有限公司 适用于增材制造的聚合物
WO2023033730A2 (en) * 2021-08-31 2023-03-09 Agency For Science, Technology And Research A method of producing a bioactive polymer filament, the bioactive polymer filament and printing methods using the same
JP7782797B2 (ja) * 2021-10-13 2025-12-09 学校法人 関西大学 分岐型生分解性ポリエステル及びその利用
CN115232297B (zh) * 2022-06-30 2023-06-27 中国神华煤制油化工有限公司 聚乙醇酸/脂肪族聚碳酸酯三嵌段共聚物及其制备方法
EP4705557A1 (en) * 2023-04-25 2026-03-11 Poly-Med Inc. Compositions and methods for nonwoven materials

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3257750B2 (ja) * 1993-07-20 2002-02-18 エチコン・インコーポレーテツド ε−カプロラクトンおよびラクチドの液状コポリマー
US5393841A (en) 1993-11-09 1995-02-28 Shell Oil Company Dissimilar arm asymmetric radial or star block copolymers for adhesives and sealants
US5462169A (en) 1994-09-23 1995-10-31 Ring Can Corporation Composite package for hazardous materials
US5633343A (en) 1995-06-30 1997-05-27 Ethicon, Inc. High strength, fast absorbing, melt processable, gycolide-rich, poly(glycolide-co-p-dioxanone) copolymers
AU707772B2 (en) 1995-11-06 1999-07-22 Ethicon Inc. Polymer blends containing polyoxaesters
US6342065B1 (en) 1999-03-17 2002-01-29 Poly-Med, Inc. High strength fibers of L-lactide copolymers ε-caprolactone and trimethylene carbonate and absorbable medical constructs thereof
US6462169B1 (en) * 1999-11-30 2002-10-08 Poly-Med, Inc. Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
US6794485B2 (en) * 2000-10-27 2004-09-21 Poly-Med, Inc. Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
US20020161168A1 (en) * 2000-10-27 2002-10-31 Shalaby Shalaby W. Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
US7265186B2 (en) 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
US6498229B1 (en) 2001-09-05 2002-12-24 Poly-Med, Inc. Direct synthesis of segmented glycolide copolymers and crystalline materials therefrom
US6794484B2 (en) 2002-06-28 2004-09-21 Ethicon, Inc. Crystallizable polylactone copolymers prepared from mono- and di-functional polymerization initiators
WO2005065079A2 (en) 2003-11-10 2005-07-21 Angiotech International Ag Medical implants and fibrosis-inducing agents
WO2005049105A2 (en) 2003-11-10 2005-06-02 Angiotech International Ag Medical implants and anti-scarring agents
EP1761283A2 (en) 2004-06-07 2007-03-14 California Institute Of Technology Biodegradable drug-polymer delivery system
US20060095122A1 (en) * 2004-10-29 2006-05-04 Advanced Cardiovascular Systems, Inc. Implantable devices comprising biologically absorbable star polymers and methods for fabricating the same
US20070043434A1 (en) * 2005-08-18 2007-02-22 David Meerkin Biodegradable endovascular stent using stereocomplexation of polymers
US9248094B2 (en) * 2006-10-30 2016-02-02 Poly-Med, Inc. Suture-specific coatings for modulated release of bioactive agents
DE102006053752A1 (de) * 2006-11-13 2008-05-15 Aesculap Ag & Co. Kg Textile Gefäßprothese mit Beschichtung
US9011439B2 (en) * 2006-11-20 2015-04-21 Poly-Med, Inc. Selectively absorbable/biodegradable, fibrous composite constructs and applications thereof
US8262723B2 (en) 2007-04-09 2012-09-11 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from polymer blends with star-block copolymers
WO2010123574A1 (en) 2009-04-23 2010-10-28 Atrp Solutions Inc Star macromolecules for personal and home care
US8858980B2 (en) * 2012-04-12 2014-10-14 Poly-Med, Inc. Synthetic mechanical hemostatic composition, method of making and use thereof
EP3215514B1 (en) 2014-11-03 2018-11-21 F. Hoffmann-La Roche AG Bace1 inhibitors

Also Published As

Publication number Publication date
JP2021008626A (ja) 2021-01-28
US12398236B2 (en) 2025-08-26
JP7549632B2 (ja) 2024-09-11
JP2023009076A (ja) 2023-01-19
WO2016100915A2 (en) 2016-06-23
EP3233963A2 (en) 2017-10-25
JP7165172B2 (ja) 2022-11-02
EP4696733A3 (en) 2026-05-06
JP2025010531A (ja) 2025-01-21
US20190359768A1 (en) 2019-11-28
WO2016100915A3 (en) 2016-11-03
JP2018501368A (ja) 2018-01-18
EP4696733A2 (en) 2026-02-18
US20160177026A1 (en) 2016-06-23
EP3233963A4 (en) 2018-08-15
EP3233963B1 (en) 2025-09-17
US20250346712A1 (en) 2025-11-13

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