JP6743821B2 - Plate-shaped hydrotalcite-type particles and their use - Google Patents
Plate-shaped hydrotalcite-type particles and their use Download PDFInfo
- Publication number
- JP6743821B2 JP6743821B2 JP2017534403A JP2017534403A JP6743821B2 JP 6743821 B2 JP6743821 B2 JP 6743821B2 JP 2017534403 A JP2017534403 A JP 2017534403A JP 2017534403 A JP2017534403 A JP 2017534403A JP 6743821 B2 JP6743821 B2 JP 6743821B2
- Authority
- JP
- Japan
- Prior art keywords
- hydrotalcite
- plate
- type particles
- powder
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002245 particle Substances 0.000 title claims description 155
- 239000002537 cosmetic Substances 0.000 claims description 42
- 238000000034 method Methods 0.000 claims description 33
- 239000011148 porous material Substances 0.000 claims description 23
- 239000000049 pigment Substances 0.000 claims description 12
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 6
- 150000001450 anions Chemical class 0.000 claims description 6
- 239000011229 interlayer Substances 0.000 claims description 6
- 238000010998 test method Methods 0.000 claims description 6
- 150000003377 silicon compounds Chemical class 0.000 claims description 5
- 239000000843 powder Substances 0.000 description 90
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 48
- -1 aluminum compound Chemical class 0.000 description 45
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 41
- 239000000284 extract Substances 0.000 description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 32
- 230000000052 comparative effect Effects 0.000 description 29
- 229910001701 hydrotalcite Inorganic materials 0.000 description 29
- 229960001545 hydrotalcite Drugs 0.000 description 29
- 239000002243 precursor Substances 0.000 description 29
- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 description 27
- 239000002002 slurry Substances 0.000 description 27
- 239000003921 oil Substances 0.000 description 26
- 235000019198 oils Nutrition 0.000 description 26
- 239000012298 atmosphere Substances 0.000 description 25
- 238000001179 sorption measurement Methods 0.000 description 25
- 239000011701 zinc Substances 0.000 description 24
- 238000005259 measurement Methods 0.000 description 21
- 239000002994 raw material Substances 0.000 description 21
- 239000000047 product Substances 0.000 description 19
- 239000007864 aqueous solution Substances 0.000 description 18
- 239000011777 magnesium Substances 0.000 description 18
- 238000006386 neutralization reaction Methods 0.000 description 17
- 235000014113 dietary fatty acids Nutrition 0.000 description 16
- 239000000194 fatty acid Substances 0.000 description 16
- 229930195729 fatty acid Natural products 0.000 description 16
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 16
- 229940085991 phosphate ion Drugs 0.000 description 16
- 229910052782 aluminium Inorganic materials 0.000 description 15
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 14
- 239000004166 Lanolin Substances 0.000 description 13
- 229910021529 ammonia Inorganic materials 0.000 description 13
- 235000019388 lanolin Nutrition 0.000 description 13
- 229940039717 lanolin Drugs 0.000 description 13
- 239000000203 mixture Substances 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- 239000004359 castor oil Substances 0.000 description 11
- 235000019438 castor oil Nutrition 0.000 description 11
- 239000013078 crystal Substances 0.000 description 11
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 11
- 239000011248 coating agent Substances 0.000 description 10
- 229910052751 metal Inorganic materials 0.000 description 10
- 239000002184 metal Substances 0.000 description 10
- 229920000642 polymer Polymers 0.000 description 10
- 229910052725 zinc Inorganic materials 0.000 description 10
- 229910007570 Zn-Al Inorganic materials 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- 238000009826 distribution Methods 0.000 description 9
- 238000001035 drying Methods 0.000 description 9
- 238000011156 evaluation Methods 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 8
- 230000032683 aging Effects 0.000 description 8
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 8
- 230000008859 change Effects 0.000 description 8
- 150000004665 fatty acids Chemical class 0.000 description 8
- 230000007794 irritation Effects 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 229910052749 magnesium Inorganic materials 0.000 description 8
- 238000010298 pulverizing process Methods 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 238000005406 washing Methods 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 238000002441 X-ray diffraction Methods 0.000 description 7
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000000635 electron micrograph Methods 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- 150000003752 zinc compounds Chemical class 0.000 description 7
- 229910003023 Mg-Al Inorganic materials 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 6
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 150000003018 phosphorus compounds Chemical class 0.000 description 6
- 239000011347 resin Substances 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- 238000005070 sampling Methods 0.000 description 6
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 5
- 150000001298 alcohols Chemical class 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 239000000470 constituent Substances 0.000 description 5
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 5
- 235000019797 dipotassium phosphate Nutrition 0.000 description 5
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 239000010445 mica Substances 0.000 description 5
- 229910052618 mica group Inorganic materials 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
- 238000012216 screening Methods 0.000 description 5
- 239000000344 soap Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 239000001993 wax Substances 0.000 description 5
- DSSYKIVIOFKYAU-OIBJUYFYSA-N (S)-camphor Chemical compound C1C[C@]2(C)C(=O)C[C@H]1C2(C)C DSSYKIVIOFKYAU-OIBJUYFYSA-N 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 229920001214 Polysorbate 60 Polymers 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 4
- 235000015278 beef Nutrition 0.000 description 4
- 238000007872 degassing Methods 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- 239000002736 nonionic surfactant Substances 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 4
- 239000011574 phosphorus Substances 0.000 description 4
- 229910052698 phosphorus Inorganic materials 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 description 4
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 4
- 229920003169 water-soluble polymer Polymers 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 235000013871 bee wax Nutrition 0.000 description 3
- 239000012166 beeswax Substances 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 3
- 229910001873 dinitrogen Inorganic materials 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 238000009616 inductively coupled plasma Methods 0.000 description 3
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 235000015424 sodium Nutrition 0.000 description 3
- 239000003760 tallow Substances 0.000 description 3
- 230000036962 time dependent Effects 0.000 description 3
- 239000010936 titanium Substances 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 3
- 229940007718 zinc hydroxide Drugs 0.000 description 3
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 3
- 239000011787 zinc oxide Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- 244000144730 Amygdalus persica Species 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 238000004438 BET method Methods 0.000 description 2
- ZCTQGTTXIYCGGC-UHFFFAOYSA-N Benzyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 ZCTQGTTXIYCGGC-UHFFFAOYSA-N 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 235000017788 Cydonia oblonga Nutrition 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 2
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 235000019482 Palm oil Nutrition 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 235000006040 Prunus persica var persica Nutrition 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- 241000220317 Rosa Species 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000003973 alkyl amines Chemical class 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 2
- QANIADJLTJYOFI-UHFFFAOYSA-K aluminum;magnesium;carbonate;hydroxide;hydrate Chemical compound O.[OH-].[Mg+2].[Al+3].[O-]C([O-])=O QANIADJLTJYOFI-UHFFFAOYSA-K 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
- 239000003212 astringent agent Substances 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical compound CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 235000014121 butter Nutrition 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 239000010495 camellia oil Substances 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000002734 clay mineral Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 235000012343 cottonseed oil Nutrition 0.000 description 2
- 239000002385 cottonseed oil Substances 0.000 description 2
- 239000007822 coupling agent Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 238000005238 degreasing Methods 0.000 description 2
- IJKVHSBPTUYDLN-UHFFFAOYSA-N dihydroxy(oxo)silane Chemical compound O[Si](O)=O IJKVHSBPTUYDLN-UHFFFAOYSA-N 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 238000001027 hydrothermal synthesis Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000001023 inorganic pigment Substances 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- 229940069445 licorice extract Drugs 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- QUAMTGJKVDWJEQ-UHFFFAOYSA-N octabenzone Chemical compound OC1=CC(OCCCCCCCC)=CC=C1C(=O)C1=CC=CC=C1 QUAMTGJKVDWJEQ-UHFFFAOYSA-N 0.000 description 2
- 229940049964 oleate Drugs 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-M oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC([O-])=O ZQPPMHVWECSIRJ-KTKRTIGZSA-M 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 239000012860 organic pigment Substances 0.000 description 2
- 239000002540 palm oil Substances 0.000 description 2
- 229960000969 phenyl salicylate Drugs 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 229940112950 sage extract Drugs 0.000 description 2
- 235000020752 sage extract Nutrition 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 238000001878 scanning electron micrograph Methods 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 239000003352 sequestering agent Substances 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 2
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 2
- 235000011069 sorbitan monooleate Nutrition 0.000 description 2
- 239000001593 sorbitan monooleate Substances 0.000 description 2
- 229940035049 sorbitan monooleate Drugs 0.000 description 2
- 235000011076 sorbitan monostearate Nutrition 0.000 description 2
- 239000001587 sorbitan monostearate Substances 0.000 description 2
- 229940035048 sorbitan monostearate Drugs 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 2
- 229960000984 tocofersolan Drugs 0.000 description 2
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 2
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 2
- 229960001763 zinc sulfate Drugs 0.000 description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 description 2
- RZLVQBNCHSJZPX-UHFFFAOYSA-L zinc sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Zn+2].[O-]S([O-])(=O)=O RZLVQBNCHSJZPX-UHFFFAOYSA-L 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- RUHCWQAFCGVQJX-RVWHZBQESA-N (3s,8s,9s,10r,13r,14s,17r)-3-hydroxy-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-1-one Chemical compound C1C=C2C[C@H](O)CC(=O)[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 RUHCWQAFCGVQJX-RVWHZBQESA-N 0.000 description 1
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- CWLGEPSKQDNHIO-JOBJLJCHSA-N (e)-n-[(e)-benzylideneamino]-1-phenylmethanimine Chemical compound C=1C=CC=CC=1/C=N/N=C/C1=CC=CC=C1 CWLGEPSKQDNHIO-JOBJLJCHSA-N 0.000 description 1
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 1
- FCAXDVKLWVSHGT-KVVVOXFISA-N (z)-docos-13-enoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O FCAXDVKLWVSHGT-KVVVOXFISA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- DXMNMEWATKSWOT-UHFFFAOYSA-N 1-[2,3-di(nonyl)phenoxy]-2,3-di(nonyl)benzene Chemical compound CCCCCCCCCC1=CC=CC(OC=2C(=C(CCCCCCCCC)C=CC=2)CCCCCCCCC)=C1CCCCCCCCC DXMNMEWATKSWOT-UHFFFAOYSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- JPPRXACMNPYJNK-UHFFFAOYSA-N 1-docosoxydocosane Chemical compound CCCCCCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCCCCCC JPPRXACMNPYJNK-UHFFFAOYSA-N 0.000 description 1
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 1
- JWKSQNWLEIABLH-UHFFFAOYSA-N 1-octan-2-yloxydodecane Chemical compound CCCCCCCCCCCCOC(C)CCCCCC JWKSQNWLEIABLH-UHFFFAOYSA-N 0.000 description 1
- QQXJNLYVPPBERR-UHFFFAOYSA-N 1-phenyldecan-1-one Chemical compound CCCCCCCCCC(=O)C1=CC=CC=C1 QQXJNLYVPPBERR-UHFFFAOYSA-N 0.000 description 1
- GQQNRZHWHWHOLI-UHFFFAOYSA-N 11-(2-decyltetradecoxymethyl)tricosane Chemical compound CCCCCCCCCCCCC(CCCCCCCCCC)COCC(CCCCCCCCCC)CCCCCCCCCCCC GQQNRZHWHWHOLI-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- ZONJATNKKGGVSU-UHFFFAOYSA-M 14-methylpentadecanoate Chemical compound CC(C)CCCCCCCCCCCCC([O-])=O ZONJATNKKGGVSU-UHFFFAOYSA-M 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- MEZZCSHVIGVWFI-UHFFFAOYSA-N 2,2'-Dihydroxy-4-methoxybenzophenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 description 1
- JNAYPSWVMNJOPQ-UHFFFAOYSA-N 2,3-bis(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C JNAYPSWVMNJOPQ-UHFFFAOYSA-N 0.000 description 1
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 description 1
- ZXDDPOHVAMWLBH-UHFFFAOYSA-N 2,4-Dihydroxybenzophenone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 ZXDDPOHVAMWLBH-UHFFFAOYSA-N 0.000 description 1
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
- XATHTZNVYDUDGS-UHFFFAOYSA-N 2-octadecylpropane-1,2,3-triol Chemical compound CCCCCCCCCCCCCCCCCCC(O)(CO)CO XATHTZNVYDUDGS-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- DUXCSEISVMREAX-UHFFFAOYSA-N 3,3-dimethylbutan-1-ol Chemical compound CC(C)(C)CCO DUXCSEISVMREAX-UHFFFAOYSA-N 0.000 description 1
- MSPJNHHBNOLHOC-UHFFFAOYSA-N 3,3-dimethylcyclopropane-1,2-dicarboxylic acid Chemical compound CC1(C)C(C(O)=O)C1C(O)=O MSPJNHHBNOLHOC-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- JOKBLKCZHGIRNO-UHFFFAOYSA-N 5-benzoyl-2-hydroxybenzoic acid Chemical compound C1=C(O)C(C(=O)O)=CC(C(=O)C=2C=CC=CC=2)=C1 JOKBLKCZHGIRNO-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- RDBLNMQDEWOUIB-UHFFFAOYSA-N 5-methyl-2-phenyl-1,3-benzoxazole Chemical compound N=1C2=CC(C)=CC=C2OC=1C1=CC=CC=C1 RDBLNMQDEWOUIB-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241001237961 Amanita rubescens Species 0.000 description 1
- 241000370685 Arge Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 235000012137 Atriplex confertifolia Nutrition 0.000 description 1
- 244000266618 Atriplex confertifolia Species 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000002568 Capsicum frutescens Nutrition 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000011632 Caseins Human genes 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 235000003301 Ceiba pentandra Nutrition 0.000 description 1
- 244000146553 Ceiba pentandra Species 0.000 description 1
- 229910052684 Cerium Inorganic materials 0.000 description 1
- 241000283153 Cetacea Species 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 241000131500 Chionoecetes opilio Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 1
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000195955 Equisetum hyemale Species 0.000 description 1
- KGWDUNBJIMUFAP-KVVVOXFISA-N Ethanolamine Oleate Chemical compound NCCO.CCCCCCCC\C=C/CCCCCCCC(O)=O KGWDUNBJIMUFAP-KVVVOXFISA-N 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 1
- 241000975394 Evechinus chloroticus Species 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 240000006927 Foeniculum vulgare Species 0.000 description 1
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 241000208690 Hamamelis Species 0.000 description 1
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 1
- 235000013719 Houttuynia cordata Nutrition 0.000 description 1
- 240000000691 Houttuynia cordata Species 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 244000280244 Luffa acutangula Species 0.000 description 1
- 235000009814 Luffa aegyptiaca Nutrition 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- QZXSMBBFBXPQHI-UHFFFAOYSA-N N-(dodecanoyl)ethanolamine Chemical compound CCCCCCCCCCCC(=O)NCCO QZXSMBBFBXPQHI-UHFFFAOYSA-N 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 244000134552 Plantago ovata Species 0.000 description 1
- 235000003421 Plantago ovata Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 235000016311 Primula vulgaris Nutrition 0.000 description 1
- 244000028344 Primula vulgaris Species 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
- 239000009223 Psyllium Substances 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 235000019774 Rice Bran oil Nutrition 0.000 description 1
- 240000007651 Rubus glaucus Species 0.000 description 1
- 235000011034 Rubus glaucus Nutrition 0.000 description 1
- 235000009122 Rubus idaeus Nutrition 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 239000006087 Silane Coupling Agent Substances 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- 239000004147 Sorbitan trioleate Substances 0.000 description 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 241000270666 Testudines Species 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 229920002359 Tetronic® Polymers 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 235000006732 Torreya nucifera Nutrition 0.000 description 1
- 244000111306 Torreya nucifera Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- NCHJGQKLPRTMAO-XWVZOOPGSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NCHJGQKLPRTMAO-XWVZOOPGSA-N 0.000 description 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
- XKMYWNHZAQUEPY-YZGJEOKZSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] 12-hydroxyoctadecanoate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCCCCCC(O)CCCCCC)C1 XKMYWNHZAQUEPY-YZGJEOKZSA-N 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- LOZDQLHDVIKMLT-UHFFFAOYSA-N [2-(2-ethylhexyl)phenyl]-phenylmethanone Chemical compound C(C)C(CC1=C(C(=O)C2=CC=CC=C2)C=CC=C1)CCCC LOZDQLHDVIKMLT-UHFFFAOYSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 229940105017 achillea millefolium extract Drugs 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 150000001343 alkyl silanes Chemical class 0.000 description 1
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 229940069521 aloe extract Drugs 0.000 description 1
- QYIXCDOBOSTCEI-UHFFFAOYSA-N alpha-cholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 QYIXCDOBOSTCEI-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 150000004645 aluminates Chemical class 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- UBNYRXMKIIGMKK-RMKNXTFCSA-N amiloxate Chemical compound COC1=CC=C(\C=C\C(=O)OCCC(C)C)C=C1 UBNYRXMKIIGMKK-RMKNXTFCSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 229940062909 amyl salicylate Drugs 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 108010045569 atelocollagen Proteins 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- IWWCATWBROCMCW-UHFFFAOYSA-N batyl alcohol Natural products CCCCCCCCCCCCCCCCCCOC(O)CO IWWCATWBROCMCW-UHFFFAOYSA-N 0.000 description 1
- 239000012179 bayberry wax Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 229950004580 benzyl nicotinate Drugs 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- WXNRYSGJLQFHBR-UHFFFAOYSA-N bis(2,4-dihydroxyphenyl)methanone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=C(O)C=C1O WXNRYSGJLQFHBR-UHFFFAOYSA-N 0.000 description 1
- SODJJEXAWOSSON-UHFFFAOYSA-N bis(2-hydroxy-4-methoxyphenyl)methanone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=C(OC)C=C1O SODJJEXAWOSSON-UHFFFAOYSA-N 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001734 carboxylic acid salts Chemical class 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 229940008396 carrot extract Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- ZMIGMASIKSOYAM-UHFFFAOYSA-N cerium Chemical compound [Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce] ZMIGMASIKSOYAM-UHFFFAOYSA-N 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- CMDKPGRTAQVGFQ-RMKNXTFCSA-N cinoxate Chemical compound CCOCCOC(=O)\C=C\C1=CC=C(OC)C=C1 CMDKPGRTAQVGFQ-RMKNXTFCSA-N 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- GFLHGTKUCYPXHB-UHFFFAOYSA-N dec-2-yn-1-ol Chemical compound CCCCCCCC#CCO GFLHGTKUCYPXHB-UHFFFAOYSA-N 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- JZKFHQMONDVVNF-UHFFFAOYSA-N dodecyl sulfate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCCOS(O)(=O)=O JZKFHQMONDVVNF-UHFFFAOYSA-N 0.000 description 1
- MCPKSFINULVDNX-UHFFFAOYSA-N drometrizole Chemical compound CC1=CC=C(O)C(N2N=C3C=CC=CC3=N2)=C1 MCPKSFINULVDNX-UHFFFAOYSA-N 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000004993 emission spectroscopy Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229960002061 ergocalciferol Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- KCDAMWRCUXGACP-DHZHZOJOSA-N ethyl (e)-2-cyano-3-phenylprop-2-enoate Chemical compound CCOC(=O)C(\C#N)=C\C1=CC=CC=C1 KCDAMWRCUXGACP-DHZHZOJOSA-N 0.000 description 1
- XRLCQRMNGQRGOC-MDZDMXLPSA-N ethyl (e)-3-[2,4-di(propan-2-yl)phenyl]prop-2-enoate Chemical compound CCOC(=O)\C=C\C1=CC=C(C(C)C)C=C1C(C)C XRLCQRMNGQRGOC-MDZDMXLPSA-N 0.000 description 1
- NYNCZOLNVTXTTP-UHFFFAOYSA-N ethyl 2-(1,3-dioxoisoindol-2-yl)acetate Chemical compound C1=CC=C2C(=O)N(CC(=O)OCC)C(=O)C2=C1 NYNCZOLNVTXTTP-UHFFFAOYSA-N 0.000 description 1
- TUKWPCXMNZAXLO-UHFFFAOYSA-N ethyl 2-nonylsulfanyl-4-oxo-1h-pyrimidine-6-carboxylate Chemical compound CCCCCCCCCSC1=NC(=O)C=C(C(=O)OCC)N1 TUKWPCXMNZAXLO-UHFFFAOYSA-N 0.000 description 1
- XCRHYAQWBYDRGV-UHFFFAOYSA-N ethyl 3-(4-propan-2-ylphenyl)prop-2-enoate Chemical compound CCOC(=O)C=CC1=CC=C(C(C)C)C=C1 XCRHYAQWBYDRGV-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229940007062 eucalyptus extract Drugs 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 239000005337 ground glass Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- SFFVATKALSIZGN-UHFFFAOYSA-N hexadecan-7-ol Chemical compound CCCCCCCCCC(O)CCCCCC SFFVATKALSIZGN-UHFFFAOYSA-N 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 235000020721 horse chestnut extract Nutrition 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000010335 hydrothermal treatment Methods 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 239000001341 hydroxy propyl starch Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000010813 internal standard method Methods 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- LDHBWEYLDHLIBQ-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide;hydrate Chemical compound O.[OH-].[O-2].[Fe+3] LDHBWEYLDHLIBQ-UHFFFAOYSA-M 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 229940094522 laponite Drugs 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 229940074358 magnesium ascorbate Drugs 0.000 description 1
- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 1
- 229940061634 magnesium sulfate heptahydrate Drugs 0.000 description 1
- AIOKQVJVNPDJKA-ZZMNMWMASA-L magnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-olate Chemical compound [Mg+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] AIOKQVJVNPDJKA-ZZMNMWMASA-L 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- SJOXEWUZWQYCGL-DVOMOZLQSA-N menthyl salicylate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C1=CC=CC=C1O SJOXEWUZWQYCGL-DVOMOZLQSA-N 0.000 description 1
- 229960004665 menthyl salicylate Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- YKWKFUUHPFWRNV-UHFFFAOYSA-N methyl 3-[2,4-di(propan-2-yl)phenyl]prop-2-enoate Chemical compound COC(=O)C=CC1=CC=C(C(C)C)C=C1C(C)C YKWKFUUHPFWRNV-UHFFFAOYSA-N 0.000 description 1
- PABHEXWDYRTPBQ-UHFFFAOYSA-N methyl 3-[2,5-di(propan-2-yl)phenyl]prop-2-enoate Chemical compound COC(=O)C=CC1=CC(C(C)C)=CC=C1C(C)C PABHEXWDYRTPBQ-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- MJVGBKJNTFCUJM-UHFFFAOYSA-N mexenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=C(C)C=C1 MJVGBKJNTFCUJM-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 229940114937 microcrystalline wax Drugs 0.000 description 1
- 239000012170 montan wax Substances 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- GSGDTSDELPUTKU-UHFFFAOYSA-N nonoxybenzene Chemical compound CCCCCCCCCOC1=CC=CC=C1 GSGDTSDELPUTKU-UHFFFAOYSA-N 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 description 1
- 229960001679 octinoxate Drugs 0.000 description 1
- 229960003921 octisalate Drugs 0.000 description 1
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical compound C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 description 1
- ZPIRTVJRHUMMOI-UHFFFAOYSA-N octoxybenzene Chemical compound CCCCCCCCOC1=CC=CC=C1 ZPIRTVJRHUMMOI-UHFFFAOYSA-N 0.000 description 1
- WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 description 1
- VIKVSUVYUVJHOA-UHFFFAOYSA-N octyl 3-phenylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C=CC1=CC=CC=C1 VIKVSUVYUVJHOA-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- UOURRHZRLGCVDA-UHFFFAOYSA-D pentazinc;dicarbonate;hexahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[O-]C([O-])=O.[O-]C([O-])=O UOURRHZRLGCVDA-UHFFFAOYSA-D 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- LYXOWKPVTCPORE-UHFFFAOYSA-N phenyl-(4-phenylphenyl)methanone Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(=O)C1=CC=CC=C1 LYXOWKPVTCPORE-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920000120 polyethyl acrylate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000000634 powder X-ray diffraction Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000011164 primary particle Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- XATKDVHSLQMHSY-RMKNXTFCSA-N propan-2-yl (e)-3-(4-methoxyphenyl)prop-2-enoate Chemical compound COC1=CC=C(\C=C\C(=O)OC(C)C)C=C1 XATKDVHSLQMHSY-RMKNXTFCSA-N 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- WZXKPNYMUZGZIA-RMKNXTFCSA-N propyl (e)-3-(4-methoxyphenyl)prop-2-enoate Chemical compound CCCOC(=O)\C=C\C1=CC=C(OC)C=C1 WZXKPNYMUZGZIA-RMKNXTFCSA-N 0.000 description 1
- 229940093625 propylene glycol monostearate Drugs 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 229940043131 pyroglutamate Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- SJOXEWUZWQYCGL-UHFFFAOYSA-N salicylic acid menthyl ester Natural products CC(C)C1CCC(C)CC1OC(=O)C1=CC=CC=C1O SJOXEWUZWQYCGL-UHFFFAOYSA-N 0.000 description 1
- 229910052706 scandium Inorganic materials 0.000 description 1
- SIXSYDAISGFNSX-UHFFFAOYSA-N scandium atom Chemical compound [Sc] SIXSYDAISGFNSX-UHFFFAOYSA-N 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 1
- 239000011163 secondary particle Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 239000012176 shellac wax Substances 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 229920003179 starch-based polymer Polymers 0.000 description 1
- 239000004628 starch-based polymer Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- JBQYATWDVHIOAR-UHFFFAOYSA-N tellanylidenegermanium Chemical compound [Te]=[Ge] JBQYATWDVHIOAR-UHFFFAOYSA-N 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- KWXLCDNSEHTOCB-UHFFFAOYSA-J tetrasodium;1,1-diphosphonatoethanol Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P(=O)([O-])C(O)(C)P([O-])([O-])=O KWXLCDNSEHTOCB-UHFFFAOYSA-J 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 238000001132 ultrasonic dispersion Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000001243 zingiber officinale rosc. root absolute Substances 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G9/00—Compounds of zinc
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Description
本発明は、板状ハイドロタルサイト型粒子及びその用途に関する。 The present invention relates to plate-like hydrotalcite-type particles and uses thereof.
ハイドロタルサイトは層状粘土鉱物の一種であり、触媒や医薬品、樹脂用添加剤等の多種多様な用途に広く使用されている。化粧料用途でも、余分な皮脂の吸着等の機能付与や、化粧崩れ、テカリの防止を期待して、粒子状のハイドロタルサイト(ハイドロタルサイト型粒子と称す)が使用されている。 Hydrotalcite is a kind of layered clay mineral and is widely used for various purposes such as catalysts, pharmaceuticals, and additives for resins. Even in cosmetic applications, particulate hydrotalcite (referred to as hydrotalcite-type particles) is used in the hope of imparting functions such as adsorption of excess sebum and preventing makeup breakdown and shine.
従来のハイドロタルサイト型粒子の多くは、マグネシウム及びアルミニウムを構成元素とするMg−Al系のハイドロタルサイト型粒子である(例えば、特許文献1参照)。だが、マグネシウム及びアルミニウムに加え、亜鉛も構成元素とするMg−Zn−Al系のハイドロタルサイト型粒子(例えば、特許文献2参照)や、亜鉛及びアルミニウムを構成元素とするZn−Al系のハイドロタルサイト型粒子(例えば、特許文献3〜6参照)も開発されている。 Most of conventional hydrotalcite-type particles are Mg-Al-based hydrotalcite-type particles containing magnesium and aluminum as constituent elements (for example, refer to Patent Document 1). However, in addition to magnesium and aluminum, Mg-Zn-Al-based hydrotalcite-type particles having zinc as a constituent element (see, for example, Patent Document 2) and Zn-Al-based hydrotalcite particles having zinc and aluminum as constituent elements. Talcite-type particles (see, for example, Patent Documents 3 to 6) have also been developed.
上述のとおり、従来のハイドロタルサイト型粒子の多くは、Mg−Al系のハイドロタルサイト型粒子であるが、構成元素であるマグネシウムに由来して塩基性を示す。化粧料等の用途では、その塩基性が皮膚を刺激して肌に悪影響を与えるため、Mg−Al系のハイドロタルサイト型粒子を使用する場合は、添加量を制限したり、他の材料との組み合わせにより塩基性を低減させたりする等を行っているのが現状である。Mg−Al系のハイドロタルサイト型粒子の塩基性を低減する手段としては、両性金属である亜鉛(Zn)をマグネシウムの一部又は全部と置換させることが考えられるが、従来のMg−Zn−Al系のハイドロタルサイト型粒子では、亜鉛は、マグネシウムサイトの一部を置換しているに留まり、塩基性が充分に低減されていない。 As described above, most of the conventional hydrotalcite-type particles are Mg-Al-based hydrotalcite-type particles, but show basicity due to the constituent element magnesium. In applications such as cosmetics, its basicity irritates the skin and adversely affects the skin. Therefore, when using Mg-Al-based hydrotalcite-type particles, the addition amount is limited or other materials are used. The present situation is to reduce the basicity by combining the above. As a means for reducing the basicity of Mg-Al-based hydrotalcite-type particles, it is considered that zinc (Zn), which is an amphoteric metal, is replaced with a part or all of magnesium. In the Al-based hydrotalcite-type particles, zinc is only partially substituting the magnesium site, and the basicity is not sufficiently reduced.
ところで、化粧料用途では、粒子の形状は、粒状よりも板状であることが望まれている。粒状粒子に比べ、滑り性が良好で、被覆性や配向性にも優れるためである。だが、従来のZn−Al系のハイドロタルサイト型粒子はアスペクト比が1〜2の粒状粒子であり、板状粒子の報告例はこれまでにない。これは、Zn−Al系のハイドロタルサイト型粒子は、Mg−Al系のハイドロタルサイト型粒子に比べ、層間の陰イオンを保持する能力が低いため、従来のMg−Al系又はMg−Zn−Al系の板状ハイドロタルサイト型粒子の合成方法をそのまま転用してZn−Al系の板状ハイドロタルサイト型粒子を製造すると、原料の水溶性亜鉛化合物(例えば、硫酸亜鉛)の一部が前駆体生成中に水酸化亜鉛になり、最終的に酸化亜鉛となってハイドロタルサイトの層状構造を維持することができないことが要因と考えられる。Zn−Al系のハイドロタルサイト型粒子を製造する方法としてはまた、前駆体スラリーをろ過することで水酸化亜鉛を取り除いた後、水熱反応等により粒子を成長させる手法(特許文献6等)もあるが、この方法でも板状粒子は得られない。 By the way, in cosmetic applications, it is desired that the shape of the particles is plate-like rather than granular. This is because, as compared with the granular particles, the slipperiness is good, and the coverage and the orientation are also excellent. However, the conventional Zn-Al-based hydrotalcite-type particles are granular particles having an aspect ratio of 1 to 2, and there have been no reports of tabular particles until now. This is because the Zn-Al-based hydrotalcite-type particles have a lower ability to retain anions between layers than the Mg-Al-based hydrotalcite-type particles, and thus the conventional Mg-Al-based or Mg-Zn-based particles are used. When the Zn-Al-based plate-like hydrotalcite-type particles are produced by directly converting the method for synthesizing the -Al-based plate-like hydrotalcite-type particles, a part of the raw water-soluble zinc compound (for example, zinc sulfate) is produced. It is considered that the factor becomes zinc hydroxide during the generation of the precursor, and finally becomes zinc oxide, which cannot maintain the layered structure of hydrotalcite. As a method of producing Zn-Al-based hydrotalcite-type particles, a method of removing particles of zinc hydroxide by filtering a precursor slurry and then growing the particles by hydrothermal reaction or the like (Patent Document 6 etc.) However, plate-like particles cannot be obtained even by this method.
本発明は、上記現状に鑑み、滑り性に優れ、皮膚への刺激性が充分に低減された板状ハイドロタルサイト型粒子を提供することを目的とする。また、このような板状ハイドロタルサイト型粒子を含む化粧料を提供することも目的とする。 The present invention has been made in view of the above circumstances, and an object thereof is to provide plate-like hydrotalcite-type particles that are excellent in slipperiness and have sufficiently reduced skin irritation. Moreover, it aims at providing the cosmetics containing such plate-like hydrotalcite type particles.
本発明者は、ハイドロタルサイト型粒子について鋭意検討を進めるうち、亜鉛とアルミニウムとを構成元素とし、かつ板状形状を有するZn−Al系のハイドロタルサイト型粒子の製造に成功した。この板状ハイドロタルサイト型粒子は、平均板面径が大きく、適度な厚みも有するうえ、所定試験方法によるpH値も適度な範囲内にあり、板状形状を有する粒子の割合が高いことから滑り性や化粧料に含めた際の肌への塗布感触が良好で、かつ皮膚への刺激性が充分に低減されたものである。その他、アンモニアガスやリン化合物の吸着性能にも優れるため、種々様々な用途に有用であることも見いだし、上記課題を解決することができることに想到し、本発明を完成するに至った。 The present inventor, while earnestly studying hydrotalcite-type particles, succeeded in producing Zn-Al-based hydrotalcite-type particles having zinc and aluminum as constituent elements and having a plate-like shape. This plate-like hydrotalcite-type particle has a large average plate surface diameter and also has an appropriate thickness, and also has a pH value according to a predetermined test method within an appropriate range, so that the proportion of particles having a plate-like shape is high. The slipperiness and the application feel on the skin when included in cosmetics are good, and the irritation to the skin is sufficiently reduced. In addition, since they are also excellent in the adsorption performance of ammonia gas and phosphorus compounds, they have been found to be useful in various applications, and have come to the conclusion that the above problems can be solved, and have completed the present invention.
すなわち本発明は、下記式(1):
(Zn)1−x(Al)x(OH)2(An−)x/n・mH2O (1)
(式中、An−は、n価の層間アニオンを表す。x及びnは、それぞれ、0.2≦x≦0.4、1≦n≦4の整数、の条件を満たす数である。mは、0以上の数である。)で表され、平均板面径が150〜800nm、アスペクト比(平均板面径/平均厚み)が4.0〜20.0、JIS K5101−17−1(2004年)の顔料試験方法によるpH値が6.0〜8.5である板状ハイドロタルサイト型粒子である。That is, the present invention provides the following formula (1):
(Zn) 1-x (Al) x (OH) 2 (A n− ) x/n ·mH 2 O (1)
(In the formula, A n− represents an n-valent interlayer anion. x and n are numbers satisfying the conditions of 0.2≦x≦0.4 and 1≦n≦4, respectively. m is a number of 0 or more.), the average plate surface diameter is 150 to 800 nm, the aspect ratio (average plate surface diameter/average thickness) is 4.0 to 20.0, JIS K5101-17-1. Plate-shaped hydrotalcite-type particles having a pH value of 6.0 to 8.5 according to the pigment test method of (2004).
上記板状ハイドロタルサイト型粒子は、BJH法による細孔容積が0.01〜1.0cm3/gであることが好ましい。これにより、粒子粉体に触れたときの、さらさら感や、均一な伸び広がり性、平滑感の持続性がより向上する他、例えば、ハイドロタルサイト粒子を含む化粧料を肌上に塗布した際に粒子が潰れることがより抑制されて、結果として平滑感の持続性がより向上する。The plate-like hydrotalcite-type particles preferably have a pore volume of 0.01 to 1.0 cm 3 /g as measured by the BJH method. As a result, when the particle powder is touched, the feeling of dryness, uniform spreadability and smoothness are further improved, and, for example, when a cosmetic containing hydrotalcite particles is applied to the skin. The particles are further suppressed from being crushed, and as a result, the sustainability of smoothness is further improved.
上記板状ハイドロタルサイト型粒子は、表面の一部又は全部がケイ素化合物で被覆されていることが好ましい。これにより、亜鉛イオンの過剰な溶出を抑制し、皮膚への刺激性を低減して適度な収斂作用を発現できることに加え、樹脂や溶媒との相溶性や分散性が向上する他、撥水性も向上するため、化粧料だけではなく、樹脂への添加剤等、各種用途により有用なものとなる。 It is preferable that a part or all of the surface of the plate-like hydrotalcite-type particles is coated with a silicon compound. This suppresses excessive elution of zinc ions, reduces irritation to the skin, and develops an appropriate astringent effect, and improves compatibility and dispersibility with resins and solvents, as well as water repellency. Since it is improved, it is useful not only for cosmetics but also for various applications such as additives to resins.
上記式(1)中、x及びnは、それぞれ、0.30≦x≦0.35、1≦n≦3の整数、の条件を満たす数であり、An−は炭酸イオン(CO3 2−)であることが好ましい。これにより、結晶形状がより安定するため、安定して優れた滑り性や化粧料に含めた際の肌への感触を与えることが可能になる。In the above formula (1), x and n are numbers satisfying the condition of 0.30≦x≦0.35 and an integer of 1≦n≦3, respectively, and A n− is a carbonate ion (CO 3 2 - ) is preferable. As a result, the crystal shape becomes more stable, so that it becomes possible to provide stable and excellent slipperiness and a feel to the skin when included in a cosmetic.
本発明はまた、上記板状ハイドロタルサイト型粒子を含む化粧料でもある。このような化粧料は、滑り性及び化粧料に含めた際の肌への塗布感触に優れ、皮膚への刺激性が充分に低減されたものである。 The present invention is also a cosmetic containing the plate-like hydrotalcite-type particles. Such a cosmetic is excellent in slipperiness and application feeling to the skin when included in the cosmetic, and the irritation to the skin is sufficiently reduced.
本発明の板状ハイドロタルサイト型粒子は、滑り性及び化粧料に含めた際の肌への塗布感触に優れ、皮膚への刺激性が充分に低減されたものであるため、特に化粧料用途に有用である。その他、アンモニアガスやリン化合物の吸着性能にも優れるため、これらの吸着性能が付加された化粧料や、吸着剤等の用途にも有用である。 The plate-like hydrotalcite-type particles of the present invention are excellent in lubricity and application feeling to the skin when included in cosmetics, and their irritation to the skin is sufficiently reduced. Useful for. In addition, since it is also excellent in the adsorption performance of ammonia gas and phosphorus compounds, it is also useful in applications such as cosmetics and adsorbents to which these adsorption performances are added.
以下、本発明の好ましい形態について具体的に説明するが、本発明は以下の記載のみに限定されるものではなく、本発明の要旨を変更しない範囲において適宜変更して適用することができる。 Hereinafter, preferred embodiments of the present invention will be specifically described, but the present invention is not limited to the following description and can be appropriately modified and applied without departing from the scope of the present invention.
〔板状ハイドロタルサイト型粒子〕
本発明の板状ハイドロタルサイト型粒子は、下記式(1):
(Zn)1−x(Al)x(OH)2(An−)x/n・mH2O (1)
(式中、An−は、n価の層間アニオンを表す。x及びnは、それぞれ、0.2≦x≦0.4、1≦n≦4の整数、の条件を満たす数である。mは、0以上の数である。)で表される板状粒子である。[Plate-shaped hydrotalcite-type particles]
The plate-like hydrotalcite-type particles of the present invention have the following formula (1):
(Zn) 1-x (Al) x (OH) 2 (A n− ) x/n ·mH 2 O (1)
(In the formula, A n− represents an n-valent interlayer anion. x and n are numbers satisfying the conditions of 0.2≦x≦0.4 and 1≦n≦4, respectively. m is a plate-like particle represented by 0 or more.).
上記式(1)中、n価の層間アニオンとしては特に限定されないが、反応性及び環境負荷低減の観点から、水酸化物イオン(OH−)、炭酸イオン(CO3 2−)及び硫酸イオン(SO4 2−)からなる群より選択される少なくとも1種が好適である。中でも、炭酸イオンが好ましい。In the above formula (1), the n-valent interlayer anion is not particularly limited, but hydroxide ion (OH − ), carbonate ion (CO 3 2− ) and sulfate ion (from the viewpoint of reactivity and reduction of environmental load). At least one selected from the group consisting of SO 4 2− ) is preferable. Of these, carbonate ion is preferable.
xは、0.2≦x≦0.4を満たす数であるが、この範囲内にあると、結晶構造が安定する。より安定性を向上させる観点から、〔(1−x)/x〕が1.5/1〜3/1となるようにxを調整することが好ましい。より好ましくは2/1となるように調整することである。この観点から、xは、0.25以上であることが好ましく、より好ましくは0.3以上であり、また、0.35以下であることが好ましい。特に好ましくは1/3(=約0.33)である。 x is a number that satisfies 0.2≦x≦0.4, but within this range, the crystal structure is stable. From the viewpoint of further improving the stability, it is preferable to adjust x so that [(1-x)/x] is 1.5/1 to 3/1. More preferably, it is adjusted to 2/1. From this viewpoint, x is preferably 0.25 or more, more preferably 0.3 or more, and preferably 0.35 or less. It is particularly preferably 1/3 (=about 0.33).
nは、1≦n≦4を満たす数であり、層間アニオンの価数によって適宜調整すればよい。好ましくは1〜3の整数、より好ましくは2である。 n is a number that satisfies 1≦n≦4, and may be appropriately adjusted depending on the valence of the interlayer anion. It is preferably an integer of 1 to 3, and more preferably 2.
mは、0以上の数である。このmは、結晶構造を解析することで理論上求めることができるが、実際には、付着水の存在等によって正確に測定することは困難である。理論上は、例えば、0以上、5未満であることが好ましい。 m is a number of 0 or more. This m can be theoretically obtained by analyzing the crystal structure, but in reality, it is difficult to accurately measure it due to the presence of attached water. Theoretically, it is preferably 0 or more and less than 5, for example.
本発明では特に、上記式(1)中、x及びnは、それぞれ、0.30≦x≦0.35、1≦n≦3の整数、の条件を満たす数であり、An−は炭酸イオン(CO3 2−)であることが好ましい。これにより、結晶形状がより安定するため、安定して、優れた滑り性や化粧料に含めた際の肌への良好な塗布感触を与えることが可能になる。In the present invention, in particular, in the above formula (1), x and n are numbers satisfying the conditions of 0.30≦x≦0.35 and 1≦n≦3, respectively, and A n− is carbonic acid. It is preferably an ion (CO 3 2− ). As a result, the crystal shape becomes more stable, so that it becomes possible to stably provide excellent slipperiness and a good application feeling to the skin when included in a cosmetic.
上記板状ハイドロタルサイト型粒子として最も好ましくは、下記式(2):
(Zn)0.67(Al)0.33(OH)2(CO3 2−)0.165・mH2O (2)
で表される板状粒子である。この構造では、結晶構造が極めて安定し、本発明の作用効果をより充分に発揮することが可能となる。この構造はJCPDSカード 00−048−1023から確認できる。Most preferably, the plate-like hydrotalcite-type particles have the following formula (2):
(Zn) 0.67 (Al) 0.33 (OH) 2 (CO 3 2− ) 0.165 ·mH 2 O (2)
It is a plate-like particle represented by. With this structure, the crystal structure is extremely stable, and the effects of the present invention can be more sufficiently exhibited. This structure can be confirmed from JCPDS card 00-048-1023.
上記板状ハイドロタルサイト型粒子の平均板面径は、150〜800nmである。平均板面径がこの範囲内にあると、粒子を含む粉体の流動性が安定することから、計量や包装時に取扱いやすいものとなり、化粧料に含めた際の肌への塗布感触や滑り性にも優れたものとなる。好ましくは180nm以上、より好ましくは190nm以上、更に好ましくは300nm以上であり、また、好ましくは500nm以下、より好ましくは470nm以下である。 The average plate surface diameter of the plate-like hydrotalcite-type particles is 150 to 800 nm. If the average plate surface diameter is within this range, the fluidity of the powder containing the particles will be stable, making it easy to handle during weighing and packaging, and when applied to cosmetics, the application feel to the skin and slipperiness Will also be excellent. The thickness is preferably 180 nm or more, more preferably 190 nm or more, further preferably 300 nm or more, and preferably 500 nm or less, more preferably 470 nm or less.
上記板状ハイドロタルサイト型粒子のアスペクト比(平均板面径/平均厚み)は、4.0〜20.0である。アスペクト比がこの範囲内にあると、粒子を含む粉体の流動性が安定することから、計量や包装時に取扱いやすいものとなり、化粧料に含めた際の肌への塗布感触や滑り性にも優れたものとなる。好ましくは4.5〜15.0、より好ましくは5.0〜10.0である。中でも、平均板面径及び平均厚みからアスペクト比を求める操作を10回繰り返した際の平均値(すなわちアスペクト比の平均値)が4.0〜20.0であることが好ましい。より好ましくは4.5〜15.0、更に好ましくは5.0〜10.0である。
本明細書中、平均板面径及び平均厚みは、走査電子顕微鏡写真に基づいて算出される値である。具体的には、後述の実施例に記載の方法に従って求められる。The aspect ratio (average plate surface diameter/average thickness) of the plate-like hydrotalcite-type particles is 4.0 to 20.0. When the aspect ratio is within this range, the fluidity of the powder containing particles is stable, which makes it easy to handle during weighing and packaging, and also has a smooth feel and slipperiness when applied to the skin when included in cosmetics. It will be excellent. It is preferably 4.5 to 15.0, and more preferably 5.0 to 10.0. Above all, the average value (that is, the average value of the aspect ratio) when the operation of obtaining the aspect ratio from the average plate surface diameter and the average thickness is repeated 10 times is preferably 4.0 to 20.0. It is more preferably 4.5 to 15.0, still more preferably 5.0 to 10.0.
In the present specification, the average plate surface diameter and the average thickness are values calculated based on scanning electron micrographs. Specifically, it is determined according to the method described in Examples below.
ここで、本発明の板状ハイドロタルサイト型粒子は、板状であり、かつ一定のアスペクト比をもつことに重要な特徴を有するが、同時に、粒子形状とアスペクト比のばらつきが少ないことにも特徴がある。化粧料に含めた際の肌への塗布感触や滑り性を向上又は維持するためには、アスペクト比を10回測定した際、測定したアスペクト比の値が4.0未満であるか又は20.0を超える回数が3回以下であることが好ましい。また、平均板面径と平均厚みを測定した際に算出される標準偏差の変動係数が、それぞれ0.5以下であることが好ましい。より好ましくは0.4以下である。 Here, the plate-like hydrotalcite-type particles of the present invention have an important feature that they are plate-like and have a constant aspect ratio, but at the same time, there is little variation in particle shape and aspect ratio. There are features. In order to improve or maintain the feel of application to the skin and the slipperiness when included in a cosmetic, the aspect ratio measured when the aspect ratio is measured 10 times is less than 4.0 or 20. The number of times exceeding 0 is preferably 3 times or less. In addition, it is preferable that the coefficient of variation of the standard deviation calculated when measuring the average plate surface diameter and the average thickness is 0.5 or less. It is more preferably 0.4 or less.
上記板状ハイドロタルサイト型粒子は、JIS K5101−17−1(2004年)の顔料試験方法によるpH値(「顔料pH」とも称す)が6.0〜8.5となるものである。この顔料pHがこの範囲内にあると、皮膚への刺激性が充分に低減されるため、化粧料等の直接肌に触れる用途に特に有用なものとなる。顔料pHは、好ましくは7.0〜8.4、より好ましくは7.2〜8.2である。
本明細書中、顔料pHは、JIS K5101−17−1(2004年)の顔料試験方法による測定値である。具体的には、後述の実施例に記載の方法に従って求められる。The plate-like hydrotalcite-type particles have a pH value (also referred to as "pigment pH") of 6.0 to 8.5 according to the pigment test method of JIS K5101-17-1 (2004). When the pigment pH is within this range, irritation to the skin is sufficiently reduced, which makes it particularly useful for applications such as cosmetics that come into direct contact with the skin. The pigment pH is preferably 7.0 to 8.4, more preferably 7.2 to 8.2.
In the present specification, the pigment pH is a value measured by a pigment test method according to JIS K5101-17-1 (2004). Specifically, it is determined according to the method described in Examples below.
上記板状ハイドロタルサイト型粒子は、その比表面積が0.1〜50m2/gであることが好ましい。比表面積がこの範囲にあると、より充分な強度を有し、滑り性及び化粧料に含めた際の肌への塗布感触がより一層優れるものとなる。より好ましくは5〜40m2/g、更に好ましくは10〜20m2/gである。The plate-like hydrotalcite-type particles preferably have a specific surface area of 0.1 to 50 m 2 /g. When the specific surface area is within this range, it has more sufficient strength, and the slipperiness and the application feeling to the skin when included in a cosmetic material are further improved. More preferably 5 to 40 m 2 / g, more preferably from 10 to 20 m 2 / g.
本明細書中、比表面積(SSAとも称する)は、BET比表面積を意味する。
BET比表面積とは、比表面積の測定方法の一つであるBET法により得られた比表面積のことをいう。比表面積とは、ある物体の単位質量あたりの表面積のことをいう。
BET法は、窒素等の気体粒子を固体粒子に吸着させ、吸着した量から比表面積を測定する気体吸着法である。具体的には、圧力Pと吸着量Vとの関係からBET式によって、単分子吸着量VMを求めることにより、比表面積を定める。本明細書中の比表面積の詳しい測定方法は後述の実施例において説明する。In the present specification, the specific surface area (also referred to as SSA) means the BET specific surface area.
The BET specific surface area refers to the specific surface area obtained by the BET method, which is one of the methods for measuring the specific surface area. Specific surface area refers to the surface area per unit mass of an object.
The BET method is a gas adsorption method in which gas particles such as nitrogen are adsorbed on solid particles and the specific surface area is measured from the adsorbed amount. Specifically, the specific surface area is determined by obtaining the monomolecular adsorption amount VM by the BET formula from the relationship between the pressure P and the adsorption amount V. The detailed method for measuring the specific surface area in the present specification will be described in Examples below.
上記板状ハイドロタルサイト型粒子は、体積基準粒度分布のシャープさの指標となるD90のD10に対する比 (D90/D10)が2〜150であることが好ましい。D90/D10がこの範囲内にあると、粒子径のバラツキが少ないため、粒子を含む粉体の流動性が安定する。それゆえ、計量や包装時に取扱いやすいものとなり、化粧料に含めた際の肌への塗布感触や滑り性にも優れたものとなる。D90/D10の値が大きくなると化粧料に含めた際の肌への塗布感触が向上する傾向にあるので、D90/D10の値は10以上がより好ましく、30以上が更に好ましい。なお、D90/D10が大きい程、粒度分布がブロードであることを意味し、この値が小さい程、粒度分布がシャープであることを意味する。
本明細書中、D10とは体積基準での10%積算粒径を意味し、D90とは体積基準での90%積算粒径を意味する。D10、D90はそれぞれ、粒度分布を測定することにより得られる値である。具体的には、後述の実施例に記載の方法に従って求められる。The plate-like hydrotalcite-type particles is preferably ratio D 10 of D 90 indicative of sharpness of volume-based particle size distribution (D 90 / D 10) is 2 to 150. When D 90 /D 10 is within this range, there is little variation in particle size, and the fluidity of the powder containing particles is stable. Therefore, it becomes easy to handle at the time of weighing and packaging, and when applied to cosmetics, the feeling of application to the skin and the slipperiness are excellent. When the value of D 90 /D 10 is large, the feel of application to the skin when included in a cosmetic composition tends to be improved, so the value of D 90 /D 10 is more preferably 10 or more, and further preferably 30 or more. A larger D 90 /D 10 means a broader particle size distribution, and a smaller value means a sharper particle size distribution.
In the present specification, D 10 means 10% cumulative particle diameter on a volume basis, and D 90 means 90% cumulative particle diameter on a volume basis. D 10 and D 90 are the values obtained by measuring the particle size distribution. Specifically, it is determined according to the method described in Examples below.
上記板状ハイドロタルサイト型粒子は、二次粒子のメジアン径(D50)が1〜200μmであることが好ましい。メジアン径(D50)がこの範囲内にあると、粒子を含む粉体の流動性が安定することから、計量や包装時に取扱いやすいものとなり、化粧料に含めた際の肌への塗布感触や滑り性にも優れたものとなる。
本明細書中、メジアン径(D50)とは体積基準での50%積算粒径を意味し、粉体をある粒子径から2つに分けたとき、大きい側と小さい側が等量となる径をいう。具体的には、後述の実施例に記載の方法に従って求められる。The median diameter (D 50 ) of secondary particles of the plate-like hydrotalcite-type particles is preferably 1 to 200 μm. When the median diameter (D 50 ) is within this range, the fluidity of the powder containing particles is stable, which makes it easy to handle during weighing and packaging, and has a feeling of application to the skin when included in cosmetics and It also has excellent slipperiness.
In the present specification, the median diameter (D 50 ) means a 50% cumulative particle diameter on a volume basis, and when a powder is divided into two from a certain particle diameter, the diameter at which the larger side and the smaller side are equal. Say. Specifically, it is determined according to the method described in Examples below.
上記板状ハイドロタルサイト型粒子はまた、化粧料に含めた際の肌への良好な塗布感触を損なわない範囲であれば、その表面の一部又は全部が表面被覆剤で被覆されていてもよい。表面被覆剤としては、無機化合物及び有機化合物のいずれも好適に用いることができる。無機化合物としては特に限定されないが、例えば、ケイ素、カルシウム、バリウム、ストロンチウム、アルミニウム、ジルコニウム、セリウム、亜鉛等の酸化物、水酸化物、硫酸塩、炭酸塩等が挙げられる。有機化合物としては特に限定されないが、例えば、シリコーンオイル、脂肪酸及びその金属塩、アルキルシラン、アルコキシシラン、シランカップリング剤、チタンカップリング剤、アルミニウムカップリング剤、アミノ酸、ナイロン、カルボマー及びその金属塩、ポリアクリル酸、トリメチルプロパノール、トリエチルアミン、高級アルコール等が挙げられる。 The plate-like hydrotalcite-type particles also have a part or all of their surfaces coated with a surface coating agent, as long as they do not impair the good application feel to the skin when they are included in a cosmetic composition. Good. As the surface coating agent, both an inorganic compound and an organic compound can be preferably used. The inorganic compound is not particularly limited, but examples thereof include oxides, hydroxides, sulfates, carbonates and the like of silicon, calcium, barium, strontium, aluminum, zirconium, cerium, zinc and the like. The organic compound is not particularly limited, and examples thereof include silicone oil, fatty acid and metal salt thereof, alkylsilane, alkoxysilane, silane coupling agent, titanium coupling agent, aluminum coupling agent, amino acid, nylon, carbomer and metal salt thereof. , Polyacrylic acid, trimethylpropanol, triethylamine, higher alcohols and the like.
上記表面被覆剤の中でも、ケイ素原子を含む化合物(ケイ素化合物とも称す)が好ましい。すなわち上記板状ハイドロタルサイト型粒子は、表面の一部又は全部がケイ素化合物で被覆されていることが好適である。これにより、亜鉛イオンの過剰な溶出を抑制し、皮膚への刺激性を低減して適度な収斂作用を発現できることに加え、樹脂や溶媒との相溶性や分散性が向上する他、撥水性も向上するため、化粧料だけではなく、樹脂への添加剤等、各種用途により有用なものとなる。ケイ素化合物としてより好ましくは、シリカである。 Among the above surface coating agents, a compound containing a silicon atom (also referred to as a silicon compound) is preferable. That is, the plate-like hydrotalcite-type particles preferably have a part or all of the surface coated with a silicon compound. This suppresses excessive elution of zinc ions, reduces irritation to the skin, and develops an appropriate astringent effect, and improves compatibility and dispersibility with resins and solvents, as well as water repellency. Since it is improved, it is useful not only for cosmetics but also for various applications such as additives to resins. Silica is more preferable as the silicon compound.
上記表面被覆剤を用いて板状ハイドロタルサイト型粒子の表面を被覆する方法としては特に限定されるものではない。例えば、シリカを用いる場合は、板状ハイドロタルサイト型粒子を含むスラリーに、珪酸ナトリウムと酸を加えて中和する方法等が挙げられる。表面被覆量は特に限定されないが、例えば、板状ハイドロタルサイト型粒子の総量100質量%に対し、シリカ等の表面被覆剤が占める割合が0.001〜30質量%であることが好ましい。より好ましくは5〜25質量%である。 The method for coating the surface of the plate-like hydrotalcite-type particles with the surface coating agent is not particularly limited. For example, when silica is used, a method in which sodium silicate and an acid are added to a slurry containing plate-shaped hydrotalcite-type particles to neutralize the slurry can be used. The surface coating amount is not particularly limited, but for example, the ratio of the surface coating agent such as silica is preferably 0.001 to 30% by mass relative to 100% by mass of the total amount of plate-like hydrotalcite-type particles. More preferably, it is 5 to 25 mass %.
上記板状ハイドロタルサイト型粒子は、吸油量が20〜300mL/100gであることが好ましい。吸油量がこの範囲内にあると、皮膚の脂取り効果が適度に得られるため、肌を刺激してヒリヒリさせることがなく、化粧料原料としてより実用的なものとなる。より好ましくは25〜200mL/100gである。
本明細書中、吸油量は、後述の実施例に記載の方法に従って求められる。The plate-like hydrotalcite-type particles preferably have an oil absorption of 20 to 300 mL/100 g. When the amount of oil absorption is within this range, a degreasing effect on the skin can be appropriately obtained, so that the skin is not irritated and irritated, and it becomes more practical as a raw material for cosmetics. More preferably, it is 25 to 200 mL/100 g.
In the present specification, the oil absorption amount is obtained according to the method described in Examples below.
上記板状ハイドロタルサイト型粒子は、BJH法による細孔容積が0.01〜1.0cm3/gであることが好ましい。細孔容積が0.01cm3/g以上であると、粒子自体の多孔性が向上するため、粒子内部の細孔での吸油性が充分なものとなり、また、粒子自体が適度な重さとなるため、粒子粉体に触ったときの、さらさら感、均一な延び広がり性、平滑感の持続性がより向上する。一方、1.0cm3/g以下であると、粒子自体の多孔性が適度なものとなるため粒子強度が充分なものとなり、ハイドロタルサイト粒子を含む化粧料を肌上に塗布した際に粒子が崩壊することが充分に抑制されて、結果として平滑性の持続性がより向上する。より好ましくは0.02〜0.5cm3/gである。
本明細書中、細孔容積は、BJH(Barrett-Joyner-Halenda)法を用いて求められる。具体的には、後述の実施例に記載の方法に従って求められる。The plate-like hydrotalcite-type particles preferably have a pore volume of 0.01 to 1.0 cm 3 /g as measured by the BJH method. When the pore volume is 0.01 cm 3 /g or more, the porosity of the particles themselves is improved, so the oil absorption in the pores inside the particles is sufficient, and the particles themselves have an appropriate weight. For this reason, when the particle powder is touched, the feeling of dryness, uniform spread and spread, and the sustainability of smoothness are further improved. On the other hand, when it is 1.0 cm 3 /g or less, the porosity of the particles themselves becomes appropriate, so that the particle strength becomes sufficient, and when the cosmetic containing hydrotalcite particles is applied onto the skin, the particles become particles. Is sufficiently suppressed, and as a result, the smoothness persistence is further improved. More preferably, it is 0.02-0.5 cm< 3 >/g.
In the present specification, the pore volume is obtained by using the BJH (Barrett-Joyner-Halenda) method. Specifically, it is determined according to the method described in Examples below.
上記板状ハイドロタルサイト型粒子は、アンモニアガスやリン化合物の吸着性能にも優れるものである。したがって、これらの吸着剤用途にも好適に使用できる。特に本発明の板状ハイドロタルサイト型粒子は、ゴミ処分場から排出される排水や、下水処理場等の浄化槽から排出される一次処理水等に含まれるリン化合物の吸着性能に優れるため、吸着剤として極めて有用である。 The plate-like hydrotalcite-type particles have excellent adsorption performance for ammonia gas and phosphorus compounds. Therefore, it can be suitably used for these adsorbent applications. In particular, the plate-like hydrotalcite-type particles of the present invention are excellent in adsorption performance of phosphorus compounds contained in wastewater discharged from waste disposal sites and primary treated water discharged from septic tanks such as sewage treatment plants. It is extremely useful as an agent.
〔製造方法〕
本発明の板状ハイドロタルサイト型粒子を得るには、例えば、亜鉛化合物及びアルミニウム化合物を原料として用い、(003)面に由来するピークの半価幅が0.4以上である前駆体を得る工程(I)と、該前駆体を、温度75〜150℃で、かつ相対湿度75〜100%RHの雰囲気下で保持する工程(II)とを含む製造方法を採用することが好ましい。このような製造方法を採用することで、水熱合成等で必要になる圧力容器等の特殊な装置・設備を導入することなく容易かつ簡便に板状ハイドロタルサイト型粒子を得ることができる。
以下、各工程について更に説明する。〔Production method〕
In order to obtain the plate-like hydrotalcite-type particles of the present invention, for example, a zinc compound and an aluminum compound are used as raw materials, and a precursor having a half-value width of a peak derived from the (003) plane of 0.4 or more is obtained. It is preferable to employ a manufacturing method including the step (I) and the step (II) of holding the precursor in an atmosphere having a temperature of 75 to 150° C. and a relative humidity of 75 to 100% RH. By adopting such a production method, plate-like hydrotalcite-type particles can be obtained easily and simply without introducing special equipment or equipment such as a pressure vessel required for hydrothermal synthesis or the like.
Hereinafter, each step will be further described.
<工程(I)>
工程(I)は、(003)面に由来するピークの半価幅が0.4以上である前駆体を得る工程である。この工程(I)ではハイドロタルサイトの結晶化を抑えて低結晶状態の前駆体を作製し、これを工程(II)に供することで、工程(II)では板状粒子への結晶成長が進み、これによって、容易かつ簡便に本発明の板状ハイドロタルサイト型粒子を得ることができる。なお、工程(I)で得られる前駆体にはハイドロタルサイト型粒子が含まれることがある。<Process (I)>
Step (I) is a step of obtaining a precursor in which the half width of the peak derived from the (003) plane is 0.4 or more. In this step (I), crystallization of hydrotalcite is suppressed to prepare a precursor in a low crystalline state, and this precursor is subjected to step (II), whereby in step (II), crystal growth into plate-like particles proceeds. Accordingly, the plate-like hydrotalcite-type particles of the present invention can be obtained easily and easily. The precursor obtained in step (I) may contain hydrotalcite-type particles.
上記工程(I)では、原料として亜鉛化合物及びアルミニウム化合物をそれぞれ1種又は2種以上用いる。これら亜鉛化合物及びアルミニウム化合物としては特に限定されないが、製造を容易にする観点から、水溶性の塩、又は、酸を含む水に可溶の塩を用いることが好ましい。具体的には、亜鉛化合物は、水酸化亜鉛、酸化亜鉛、塩基性炭酸亜鉛及び硫酸亜鉛からなる群より選択される少なくとも1種であることが好ましく、アルミニウム化合物は、水酸化アルミニウム、酸化アルミニウム及び硫酸アルミニウムからなる群より選択される少なくとも1種であることが好ましい。これらの原料を用いることで、より容易かつ簡便に板状ハイドロタルサイト型粒子を得ることができる。 In the step (I), one or more zinc compounds and aluminum compounds are used as raw materials. Although these zinc compounds and aluminum compounds are not particularly limited, it is preferable to use a water-soluble salt or a water-soluble salt containing an acid from the viewpoint of facilitating the production. Specifically, the zinc compound is preferably at least one selected from the group consisting of zinc hydroxide, zinc oxide, basic zinc carbonate and zinc sulfate, and the aluminum compound is aluminum hydroxide, aluminum oxide and It is preferably at least one selected from the group consisting of aluminum sulfate. By using these raw materials, plate-like hydrotalcite-type particles can be obtained more easily and easily.
上記原料の使用量は、得られる板状ハイドロタルサイト型粒子が上記式(1)を満たすものとなるように調整すればよい。例えば、アルミニウム化合物のアルミニウム換算量1モルに対し、亜鉛化合物が、亜鉛換算で1.5〜4モルとなるようにすることが好ましい。これにより、得られる板状ハイドロタルサイト型粒子の結晶構造が安定する。より安定性を向上させる観点から、アルミニウム化合物のアルミニウム換算量1モルに対し、亜鉛化合物が、亜鉛換算で1.5〜3モルとなるように調整することがより好ましく、更に好ましくは2モルである。 The amount of the above raw material used may be adjusted so that the resulting plate-like hydrotalcite-type particles satisfy the above formula (1). For example, it is preferable that the zinc compound is 1.5 to 4 mol in terms of zinc, relative to 1 mol of the aluminum compound in terms of aluminum. This stabilizes the crystal structure of the plate-like hydrotalcite-type particles obtained. From the viewpoint of further improving the stability, it is more preferable to adjust the zinc compound to be 1.5 to 3 mol in terms of zinc, relative to 1 mol of the aluminum compound in terms of aluminum, and more preferably 2 mol. is there.
上記工程(I)では、上記原料を、アルカリ成分を用いて中和することが好ましい。この中和を行うことで、前駆体を好適に得ることができる。この中和は、上記原料とアルカリ成分との混合溶液のpHが7以上になるように、上記原料とアルカリ成分とを混合することが好ましい。この際、必要に応じて後述する溶媒の存在下で行ってもよい。より好ましくは、上記原料とアルカリ成分との混合溶液のpHが7.5以上になるように中和反応させることである。 In the step (I), it is preferable to neutralize the raw material with an alkaline component. By carrying out this neutralization, the precursor can be suitably obtained. In this neutralization, it is preferable to mix the raw material and the alkaline component so that the pH of the mixed solution of the raw material and the alkaline component becomes 7 or more. At this time, it may be carried out in the presence of a solvent described later, if necessary. More preferably, the neutralization reaction is carried out so that the pH of the mixed solution of the above raw material and the alkaline component becomes 7.5 or more.
上記アルカリ成分としては特に限定されないが、例えば、アルカリ金属塩等が挙げられ、1種又は2種以上を使用することができる。アルカリ金属塩とは、例えば、リチウム、ナトリウム、カリウム等のアルカリ金属の塩であり、塩として、水酸化物、炭酸塩、炭酸水素塩、珪酸塩、アルミン酸塩、有機アミン塩等が挙げられる。中でも、水酸化ナトリウム、炭酸ナトリウム、炭酸水素ナトリウム等が好適である。 The alkali component is not particularly limited, and examples thereof include alkali metal salts and the like, and one kind or two or more kinds can be used. The alkali metal salt is, for example, a salt of an alkali metal such as lithium, sodium and potassium, and examples of the salt include hydroxide, carbonate, hydrogen carbonate, silicate, aluminate, organic amine salt and the like. .. Among them, sodium hydroxide, sodium carbonate, sodium hydrogen carbonate and the like are preferable.
上記溶媒としては特に限定されず、水、有機溶媒及びこれらの混合物が挙げられ、1種又は2種以上を使用することができる。有機溶媒としては、例えば、アルコール、アセトン、ジメチルスルホキシド、ジメチルホルムアミド、テトラヒドロフラン、ジオキサン等が挙げられ、アルコールとしては、メタノール、エタノール、プロパノール等の1価の水溶性アルコール;エチレングリコール、グリセリン等の2価以上の水溶性アルコール;等が挙げられる。溶媒として好ましくは水であり、より好ましくはイオン交換水である。 The above-mentioned solvent is not particularly limited, and examples thereof include water, an organic solvent and a mixture thereof, and one kind or two or more kinds can be used. Examples of the organic solvent include alcohol, acetone, dimethylsulfoxide, dimethylformamide, tetrahydrofuran, dioxane and the like, and examples of the alcohol include monohydric water-soluble alcohols such as methanol, ethanol and propanol; ethylene glycol, glycerin and the like 2. A water-soluble alcohol having a valency or more; or the like. The solvent is preferably water, more preferably ion-exchanged water.
ここで、原料として炭酸塩を用いない場合、あるいは、炭酸塩を用いても生成した粒子が上記式(1)を満たさない場合は、別途炭酸ガスを用いてもよい。炭酸ガスは、工程(I)の中であればどの操作で用いてもよい。 Here, when a carbonate is not used as a raw material, or when the particles produced by using a carbonate do not satisfy the above formula (1), carbon dioxide may be separately used. Carbon dioxide may be used in any operation during the step (I).
上記工程(I)ではまた、上記中和で溶媒を用いた場合、得られたスラリーを乾燥することが好適である。この乾燥は、スラリーから溶媒が除去されるように行えばよく、乾燥手段は特に限定されるものではない。例えば、減圧乾燥、加熱乾燥等が挙げられる。また、スラリーをそのまま乾燥してもよいし、ろ過し水洗してから乾燥してもよい。ろ過し水洗してから乾燥する場合は、一旦スラリーの状態にしてから噴霧乾燥で乾燥することも好ましい。 In the step (I), when the solvent is used in the neutralization, it is preferable to dry the obtained slurry. This drying may be performed so that the solvent is removed from the slurry, and the drying means is not particularly limited. For example, vacuum drying, heat drying and the like can be mentioned. The slurry may be dried as it is, or may be filtered, washed with water and then dried. When it is filtered, washed with water and then dried, it is also preferable to once make it into a slurry state and then dry it by spray drying.
上記乾燥の後、粉砕を行うことが好適である。すなわち上記工程(I)は、溶媒の存在下で原料を中和する中和と、該中和により得られたスラリーの乾燥と、乾燥したものの粉砕とを含むことが好ましい。粉砕方法及び粉砕条件は特に限定されず、例えば、ボールミル、ライカイ機、フォースミル、ハンマーミル、ジェットミル等を用いて行ってもよい。 It is preferable to carry out pulverization after the drying. That is, the step (I) preferably includes neutralization for neutralizing the raw material in the presence of a solvent, drying of the slurry obtained by the neutralization, and pulverization of the dried product. The pulverizing method and pulverizing conditions are not particularly limited, and for example, a ball mill, a liquor machine, a force mill, a hammer mill, a jet mill or the like may be used.
上記工程(I)で得られる前駆体は、ウエットケーキ状(例えば、105℃で18時間乾燥後、測定した固形分が15質量%以上である状態)であってもよいし、粉体状であってもよいが、中でも、粉体状であることが好適である。粉体状の前駆体を工程(II)に供すると、工程(II)では板状粒子への結晶成長がより進み、かつ一次粒子の過度の凝集を抑制できるため、好ましい。 The precursor obtained in the above step (I) may be in a wet cake form (for example, in a state where the measured solid content is 15% by mass or more after drying at 105° C. for 18 hours), or a powder form. It may be present, but among them, powdery one is preferable. When the powdery precursor is subjected to the step (II), the crystal growth into the plate-like particles is further advanced in the step (II) and the excessive aggregation of the primary particles can be suppressed, which is preferable.
上記工程(I)で得られる前駆体が粉状態(粉体状)である場合、前記の方法で測定した固形分量が85重量%以上であることが好ましく、95重量%以上であることがより好ましい。 When the precursor obtained in the step (I) is in a powder state (powder form), the solid content measured by the above method is preferably 85% by weight or more, and more preferably 95% by weight or more. preferable.
上記前駆体は、(003)面に由来するピークの半価幅が0.4以上となるものである。半価幅が0.4未満であるような高結晶状態の前駆体であると、これを工程(II)に供しても充分に板状化が進まないため、平均板面径及びアスペクト比が本発明の範囲内となる板状ハイドロタルサイト型粒子を得ることができない。前駆体の(003)面に由来するピークの半価幅は、好ましくは0.5以上、より好ましくは0.6以上、更に好ましくは0.7以上である。また、上限は、3以下であることが好ましい。より好ましくは2以下、更に好ましくは1.2以下である。 In the above precursor, the half width of the peak derived from the (003) plane is 0.4 or more. When the precursor in a highly crystalline state having a half-value width of less than 0.4 does not sufficiently plate-form even when it is subjected to the step (II), the average plate surface diameter and the aspect ratio are It is not possible to obtain plate-like hydrotalcite-type particles within the scope of the present invention. The half width of the peak derived from the (003) plane of the precursor is preferably 0.5 or more, more preferably 0.6 or more, and further preferably 0.7 or more. The upper limit is preferably 3 or less. It is more preferably 2 or less, still more preferably 1.2 or less.
上記前駆体はまた、(006)面に由来するピークの半価幅が0.4以上であることも好ましい。より好ましくは0.5以上、更に好ましくは0.6以上、特に好ましくは0.7以上である。また、上限は、3以下であることが好ましい。より好ましくは2以下、更に好ましくは1以下である。
本明細書中、半価幅は、X線回折法により求めることができる。具体的には、後述する実施例に記載の手法により求められる。It is also preferable that the above-mentioned precursor has a half-value width of a peak derived from the (006) plane of 0.4 or more. It is more preferably 0.5 or more, still more preferably 0.6 or more, and particularly preferably 0.7 or more. The upper limit is preferably 3 or less. It is more preferably 2 or less, still more preferably 1 or less.
In the present specification, the full width at half maximum can be determined by an X-ray diffraction method. Specifically, it is determined by the method described in Examples below.
上記前駆体は更に、その比表面積が20m2/gを超えて300m2/g以下であることが好ましい。このような前駆体を工程(II)に供することで、得られる板状ハイドロタルサイト型粒子の強度や滑り性、化粧料に含めた際の肌への塗布感触がより良好なものとなる。より好ましくは25m2/g以上、更に好ましくは30m2/g以上である。比表面積の上限値は、より好ましくは250m2/g以下である。Furthermore, the precursor preferably has a specific surface area of more than 20 m 2 /g and 300 m 2 /g or less. By subjecting such a precursor to the step (II), the strength and slipperiness of the resulting plate-like hydrotalcite-type particles and the feel of application to the skin when included in a cosmetic composition are improved. It is more preferably 25 m 2 /g or more, still more preferably 30 m 2 /g or more. The upper limit of the specific surface area is more preferably 250 m 2 /g or less.
<工程(II)>
工程(II)は、上記工程(I)により得た前駆体を、温度75〜150℃で、かつ相対湿度75〜100%RHの雰囲気下で保持する工程(「湿潤雰囲気工程」とも称す)である。上記製造方法では、従来法のような水熱や常圧での反応とは異なり、前駆体を高温高湿雰囲気下に保持するだけの工程を経ることで、簡便な手段により板状ハイドロタルサイト型粒子を得ることができるため、圧力容器等の特別な装置を不要にすることができる。すなわち製造設備を簡単にすることができる。<Step (II)>
The step (II) is a step (also referred to as “wet atmosphere step”) of holding the precursor obtained in the above step (I) under an atmosphere of a temperature of 75 to 150° C. and a relative humidity of 75 to 100% RH. is there. In the above-mentioned production method, unlike the reaction under the hydrothermal or atmospheric pressure as in the conventional method, the plate-like hydrotalcite is produced by a simple means by undergoing a step of holding the precursor in a high temperature and high humidity atmosphere. Since shaped particles can be obtained, a special device such as a pressure vessel can be eliminated. That is, the manufacturing equipment can be simplified.
上記工程(II)では、温度75〜150℃で前駆体を保持する。板状化を促進させる観点から、温度は76℃以上であることが好ましく、より好ましくは78℃以上、更に好ましくは80℃以上である。また、製造コストや設備仕様の観点から、95℃以下とすることが好ましい。
本明細書中、工程(II)の保持温度は、当該工程での最高到達温度を意味する。
なお、温度の変動は板状粒子の結晶成長に変化をもたらす場合があるため、保持中の温度の上限と下限の差が10℃以下とすることが好ましい。In the step (II), the precursor is held at a temperature of 75 to 150°C. From the viewpoint of promoting plate formation, the temperature is preferably 76°C or higher, more preferably 78°C or higher, and further preferably 80°C or higher. From the viewpoint of manufacturing cost and equipment specifications, the temperature is preferably 95°C or lower.
In the present specification, the holding temperature of the step (II) means the highest temperature reached in the step.
In addition, since the temperature fluctuation may change the crystal growth of the plate-like particles, the difference between the upper limit and the lower limit of the temperature during holding is preferably 10° C. or less.
上記工程(II)はまた、相対湿度が75〜100%RHの雰囲気で行う。板状化を促進させる観点から、相対湿度は76%RH以上であることが好ましく、より好ましくは77%RH以上、更に好ましくは78%RH以上、特に好ましくは79%RH以上、最も好ましくは80%RH以上である。また、製造コストや設備仕様の観点から、95%RH以下とすることが好ましく、より好ましくは90%RH以下である。
本明細書中、工程(II)の相対湿度は、当該工程での最高到達湿度を意味する。
なお、相対湿度の変動は板状粒子の結晶成長に変化をもたらす場合があるため、保持中の湿度の上限と下限の差を10%以下とすることが好ましい。The step (II) is also performed in an atmosphere having a relative humidity of 75 to 100% RH. From the viewpoint of promoting plate formation, the relative humidity is preferably 76% RH or more, more preferably 77% RH or more, further preferably 78% RH or more, particularly preferably 79% RH or more, and most preferably 80%. %RH or more. From the viewpoint of manufacturing cost and equipment specifications, it is preferably 95% RH or less, and more preferably 90% RH or less.
In the present specification, the relative humidity in the step (II) means the maximum reached humidity in the step.
Since the fluctuation of the relative humidity may change the crystal growth of the plate-like particles, the difference between the upper limit and the lower limit of the humidity during holding is preferably 10% or less.
上記条件下での保持時間は、前駆体が板状粒子に結晶成長するのに充分な時間であればよい。例えば、1〜300時間であることが好ましい。保持時間がこの範囲内であると、結晶化がより充分に進み、生産性にも優れる。より好ましくは3〜200時間、更に好ましくは6〜180時間である。 The holding time under the above conditions may be a time sufficient for the precursor to grow crystals into plate-like particles. For example, it is preferably 1 to 300 hours. If the holding time is within this range, crystallization will proceed more sufficiently and the productivity will be excellent. It is more preferably 3 to 200 hours, further preferably 6 to 180 hours.
<他の工程>
上記製造方法では、上述した工程(I)及び(II)に加え、必要に応じて1又は2以上の粉砕、分級、洗浄、水熱、熟成、焼成、層間イオンの置換、表面被覆等のその他の工程を含んでもよい。その他の工程は特に限定されない。<Other process>
In the above-mentioned production method, in addition to the above-mentioned steps (I) and (II), if necessary, one or more of pulverization, classification, washing, hydrothermal treatment, aging, firing, substitution of interlayer ions, surface coating, etc. May be included. Other steps are not particularly limited.
〔用途〕
本発明の板状ハイドロタルサイト型粒子は、滑り性及び化粧料に含めた際の肌への塗布感触に優れ、皮膚への刺激性が充分に低減されたものであり、しかもアンモニアガスやリン化合物の吸着性能にも優れるものである。したがって、化粧料、医薬品、医薬部外品、吸着剤、触媒、樹脂用添加剤等の種々の用途に用いることができる。中でも、化粧料原料として特に有用であり、上記板状ハイドロタルサイト型粒子を含む化粧料は、本発明の1つである。[Use]
The plate-like hydrotalcite-type particles of the present invention are excellent in slipperiness and application feeling to the skin when included in cosmetics, and have sufficiently reduced skin irritation, and ammonia gas and phosphorus. It also has excellent compound adsorption performance. Therefore, it can be used for various purposes such as cosmetics, pharmaceuticals, quasi drugs, adsorbents, catalysts, additives for resins and the like. Among them, a cosmetic material which is particularly useful as a raw material for cosmetics and contains the plate-like hydrotalcite-type particles is one of the present inventions.
上記化粧料は、本発明の板状ハイドロタルサイト型粒子を含むことで、肌への刺激性が低減され、滑りが良く、かつ化粧料に含めた際の肌への塗布感触に優れるうえ、ソフトフォーカス効果や皮脂吸着効果も期待できるものである。それゆえ、昨今の市場のニーズに特に適したものである。化粧料としては特に限定されず、例えば、ファンデーション、化粧下地、日焼け止め、アイシャドウ、頬紅、マスカラ、口紅、制汗剤、脂取り紙等が挙げられる。中でも、ファンデーションが特に好適である。 The cosmetic contains the plate-shaped hydrotalcite-type particles of the present invention, irritation to the skin is reduced, slipperiness is good, and the application feeling to the skin when included in the cosmetic is excellent, Soft focus effect and sebum adsorption effect can be expected. Therefore, it is particularly suited to the needs of the market today. The cosmetics are not particularly limited, and examples thereof include foundations, makeup bases, sunscreens, eye shadows, blushers, mascaras, lipsticks, antiperspirants, degreasing papers and the like. Among them, the foundation is particularly suitable.
上記化粧料はまた、必要に応じ、本発明の板状ハイドロタルサイト型粒子に加えて、他の成分を1種又は2種以上含んでいてもよい。他の成分は特に限定されないが、例えば、有機溶媒や分散剤の他、化粧料分野で通常使用されている任意の水性成分、油性成分が挙げられる。具体的には、油分;界面活性剤;保湿剤;高級アルコール;金属イオン封鎖剤;各種高分子(天然、半合成、合成若しくは無機の、水溶性又は油溶性高分子);紫外線遮蔽剤;その他薬剤成分;各種抽出液;無機及び有機顔料;無機及び有機粘土鉱物等の各種粉体;金属石鹸処理又はシリコーンで処理された無機及び有機顔料;有機染料等の色剤;防腐剤;酸化防止剤;色素;増粘剤;pH調整剤;香料;冷感剤;収斂剤;殺菌剤;皮膚賦活剤;等が挙げられる。これらの成分の含有量は、本発明の効果を損なわない範囲であれば特に限定されない。 In addition to the plate-like hydrotalcite-type particles of the present invention, the above-mentioned cosmetic may contain one or more other components, if necessary. Other components are not particularly limited, and include, for example, an organic solvent and a dispersant, as well as any aqueous component and oil component generally used in the cosmetic field. Specifically, oils; surfactants; humectants; higher alcohols; sequestering agents; various polymers (natural, semi-synthetic, synthetic or inorganic, water-soluble or oil-soluble polymers); UV screening agents; Ingredients; Various extracts; Inorganic and organic pigments; Various powders of inorganic and organic clay minerals; Inorganic and organic pigments treated with metal soap or silicone; Coloring agents such as organic dyes; Preservatives; Antioxidants Dyes, thickeners, pH adjusters, fragrances, cooling agents, astringents, bactericides, skin activating agents, and the like. The contents of these components are not particularly limited as long as the effects of the present invention are not impaired.
油分としては特に限定されず、例えば、アボカド油、ツバキ油、タートル油、マカデミアナッツ油、トウモロコシ油、ミンク油、オリーブ油、ナタネ油、卵黄油、ゴマ油、パーシック油、小麦胚芽油、サザンカ油、ヒマシ油、アマニ油、サフラワー油、綿実油、エノ油、大豆油、落花生油、茶実油、カヤ油、コメヌカ油、シナギリ油、日本キリ油、ホホバ油、胚芽油、トリグリセリン、トリオクタン酸グリセリン、トリイソパルミチン酸グリセリン、カカオ脂、ヤシ油、馬脂、パーム油、牛脂、羊脂、パーム核油、豚脂、牛骨脂、モクロウ核油、硬化牛脂、硬化ヤシ油、硬化ひまし油等の硬化油、牛脚脂、モクロウ、ミツロウ、カンデリラロウ、綿ロウ、カルナウバロウ、ベイベリーロウ、イボタロウ、鯨ロウ、モンタンロウ、ヌカロウ、ラノリン、カポックロウ、酢酸ラノリン、液状ラノリン、サトウキビロウ、ラノリン脂肪酸イソプロピル、ラウリン酸ヘキシル、還元ラノリン、ジョジョバロウ、硬質ラノリン、セラックロウ、POEラノリンアルコールエーテル、POEラノリンアルコールアセテート、POEコレステロールエーテル、ラノリン脂肪酸ポリエチレングリコール、POE水素添加ラノリンアルコールエーテル、流動パラフィン、オゾケライト、プリスタン、パラフィン、セレシン、スクワレン、ワセリン、マイクロクリスタリンワックス等が挙げられる。 The oil content is not particularly limited, and examples thereof include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern oil, castor oil. , Linseed oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, cinnamon oil, Japanese chili oil, jojoba oil, germ oil, triglycerin, glyceryl trioctanoate, tri Hardened oils such as glycerin isopalmitate, cacao butter, coconut oil, horse fat, palm oil, beef tallow, sheep fat, palm kernel oil, lard, beef butter, mokuro kernel oil, hardened beef tallow, hardened palm oil, hardened castor oil , Beef tallow, mokuro, beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ivota wax, whale wax, montan wax, nukarou, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin , Jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, liquid paraffin, ozokerite, pristane, paraffin, ceresin, squalene, vaseline, Microcrystalline wax and the like can be mentioned.
界面活性剤としては、例えば、親油性非イオン界面活性剤、親水性非イオン界面活性剤の他、その他の界面活性剤が挙げられる。親油性非イオン界面活性剤としては特に限定されず、例えば、ソルビタンモノオレエート、ソルビタンモノイソステアレート、ソルビタンモノラウレート、ソルビタンモノパルミテート、ソルビタンモノステアレート、ソルビタンセスキオレエート、ソルビタントリオレエート、ペンタ−2−エチルヘキシル酸ジグリセロールソルビタン、テトラ−2−エチルヘキシル酸ジグリセロールソルビタン等のソルビタン脂肪酸エステル類、モノ綿実油脂肪酸グリセリン、モノエルカ酸グリセリン、セスキオレイン酸グリセリン、モノステアリン酸グリセリン、α,α’−オレイン酸ピログルタミン酸グリセリン、モノステアリン酸グリセリンリンゴ酸等のグリセリンポリグリセリン脂肪酸類、モノステアリン酸プロピレングリコール等のプロピレングリコール脂肪酸エステル類、硬化ヒマシ油誘導体、グリセリンアルキルエーテル等が挙げられる。 Examples of the surfactant include lipophilic nonionic surfactants, hydrophilic nonionic surfactants, and other surfactants. The lipophilic nonionic surfactant is not particularly limited, and examples thereof include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate. , Sorbitan fatty acid esters such as penta-2-ethylhexylate diglycerol sorbitan, tetra-2-ethylhexylate diglycerol sorbitan, mono cottonseed oil fatty acid glycerin, monoerucic acid glycerin, sesquioleate glycerin, monostearate glycerin, α,α' -Glycerin oleate pyroglutamate, glycerin polyglycerin fatty acid such as glycerin monostearate malic acid, propylene glycol fatty acid ester such as propylene glycol monostearate, hydrogenated castor oil derivative, glycerin alkyl ether and the like.
親水性非イオン界面活性剤としては特に限定されず、例えば、POEソルビタンモノオレエート、POEソルビタンモノステアレート、POEソルビタンテトラオレエート等のPOEソルビタン脂肪酸エステル類、POEソルビットモノラウレート、POEソルビットモノオレエート、POEソルビットペンタオレエート、POEソルビットモノステアレート等のPOEソルビット脂肪酸エステル類、POEグリセリンモノステアレート、POEグリセリンモノイソステアレート、POEグリセリントリイソステアレート等のPOEグリセリン脂肪酸エステル類、POEモノオレエート、POEジステアレート、POEモノジオレエート、システアリン酸エチレングリコール等のPOE脂肪酸エステル類、POEラウリルエーテル、POEオレイルエーテル、POEステアリルエーテル、POEベヘニルエーテル、POE2−オクチルドデシルエーテル、POEコレスタノールエーテル等のPOEアルキルエーテル類、POEオクチルフェニルエーテル、POEノニルフェニルエーテル、POEジノニルフェニルエーテル等のPOEアルキルフェニルエーテル類、ブルロニック等のプルアロニック型類、POE・POPセチルエーテル、POE・POP2−デシルテトラデシルエーテル、POE・POPモノブチルエーテル、POE・POP水添ラノリン、POE・POPグリセリンエーテル等のPOE・POPアルキルエーテル類、テトロニック等のテトラPOE・テトラPOPエチレンジアミン縮合物類、POEヒマシ油、POE硬化ヒマシ油、POE硬化ヒマシ油モノイソステアレート、POE硬化ヒマシ油トリイソステアレート、POE硬化ヒマシ油モノピログルタミン酸モノイソステアリン酸ジエステル、POE硬化ヒマシ油マレイン酸等のPOEヒマシ油硬化ヒマシ油誘導体、POEソルビットミツロウ等のPOEミツロウ・ラノリン誘導体、ヤシ油脂肪酸ジエタノールアミド、ラウリン酸モノエタノールアミド、脂肪酸イソプロパノールアミド等のアルカノールアミド、POEプロピレングリコール脂肪酸エステル、POEアルキルアミン、POE脂肪酸アミド、ショ糖脂肪酸エステル、POEノニルフェニルホルムアルデヒド縮合物、アルキルエトキシジメチルアミンオキシド、トリオレイルリン酸等が挙げられる。 The hydrophilic nonionic surfactant is not particularly limited, and examples thereof include POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan tetraoleate and other POE sorbitan fatty acid esters, POE sorbit monolaurate, POE sorbit monolate. POE glycerin fatty acid esters such as oleate, POE sorbit pentaoleate, POE sorbit monostearate, POE glycerin monostearate, POE glycerin monoisostearate, POE glycerin triisostearate, POE POE fatty acid esters such as monooleate, POE distearate, POE monodioleate, ethylene glycol distearate, POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE 2-octyldodecyl ether, POE cholestanol ether, etc. POE alkyl phenyl ethers such as ethers, POE octyl phenyl ether, POE nonyl phenyl ether, and POE dinonyl phenyl ether, Pluronic types such as Bourronic, POE/POP cetyl ether, POE/POP 2-decyl tetradecyl ether, POE/ POP monobutyl ether, POE/POP hydrogenated lanolin, POE/POP alkyl ethers such as POE/POP glycerin ether, tetra-POE/tetra-POP ethylenediamine condensates such as Tetronic, POE castor oil, POE hardened castor oil, POE hardened Castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE hydrogenated castor oil POE such as maleic acid, castor oil hydrogenated castor oil derivative, POE such as POE sorbit beeswax Beeswax lanolin derivative, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide and other alkanolamides, POE propylene glycol fatty acid ester, POE alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonylphenylformaldehyde condensate , Alkylethoxydimethylamine oxide, trioleyl phosphoric acid and the like.
その他の界面活性剤としては、例えば、脂肪酸セッケン、高級アルキル硫酸エステル塩、POEラウリル硫酸トリエタノールアミン、アルキルエーテル硫酸エステル塩等のアニオン界面活性剤、アルキルトリメチルアンモニウム塩、アルキルピリジニウム塩、アルキル四級アンモニウム塩、アルキルジメチルベンジルアンモニウム塩、POEアルキルアミン、アルキルアミン塩、ポリアミン脂肪酸誘導体等のカチオン界面活性剤、イミダゾリン系両性界面活性剤、ベタイン系界面活性剤等の両性界面活性剤等が挙げられる。 Examples of other surfactants include anionic surfactants such as fatty acid soap, higher alkyl sulfate ester salt, POE lauryl sulfate triethanolamine, and alkyl ether sulfate ester salt, alkyl trimethyl ammonium salt, alkyl pyridinium salt, alkyl quaternary salt. Examples thereof include cationic surfactants such as ammonium salts, alkyldimethylbenzylammonium salts, POE alkylamines, alkylamine salts and polyamine fatty acid derivatives, amphoteric surfactants such as imidazoline-based amphoteric surfactants and betaine-based surfactants.
保湿剤としては特に限定されず、例えば、キシリトール、ソルビトール、マルチトール、コンドロイチン硫酸、ヒアルロン酸、ムコイチン硫酸、カロニン酸、アテロコラーゲン、コレステリル−12−ヒドロキシステアレート、乳酸ナトリウム、胆汁酸塩、dl−ピロリドンカルボン酸塩、短鎖可溶性コラーゲン、ジグリセリン(EO)PO付加物、イザヨイバラ抽出物、セイヨウノコギリソウ抽出物、メリロート抽出物等が挙げられる。 The humectant is not particularly limited, and examples thereof include xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salt, dl-pyrrolidone. Examples thereof include carboxylic acid salts, short-chain soluble collagen, diglycerin (EO)PO adducts, Isaioba rose extract, Achillea millefolium extract, Merrilot extract and the like.
高級アルコールとしては特に限定されず、例えば、ラウリルアルコール、セチルアルコール、ステアリルアルコール、ベヘニルアルコール、ミリスチルアルコール、オレイルアルコール、セトステアリルアルコール等の直鎖アルコール、モノステアリルグリセリンエーテル(バチルアルコール)、2−デシルテトラデシノール、ラノリンアルコール、コレステロール、フィトステロール、ヘキシルドデカノール、イソステアリルアルコール、オクチルドデカノール等の分枝鎖アルコール等が挙げられる。 The higher alcohol is not particularly limited, and examples thereof include linear alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, and cetostearyl alcohol, monostearyl glycerin ether (batyl alcohol), 2-decyltetra. Branched chain alcohols such as decynol, lanolin alcohol, cholesterol, phytosterol, hexyldecanol, isostearyl alcohol, octyldodecanol and the like can be mentioned.
金属イオン封鎖剤としては特に限定されず、例えば、1−ヒドロキシエタン−1,1− ジフォスホン酸、1−ヒドロキシエタン−1,1−ジフォスホン酸四ナトリウム塩、クエン酸ナトリウム、ポリリン酸ナトリウム、メタリン酸ナトリウム、グルコン酸、リン酸、クエン酸、アスコルビン酸、コハク酸、エデト酸等が挙げられる。 The sequestering agent is not particularly limited, and examples thereof include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, sodium citrate, sodium polyphosphate, and metaphosphoric acid. Examples thereof include sodium, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid and edetic acid.
天然の水溶性高分子としては特に限定されず、例えば、アラビアガム、トラガカントガム、ガラクタン、グアガム、キャロブガム、カラヤガム、カラギーナン、ペクチン、カンテン、クインスシード(マルメロ)、アルゲコロイド(カッソウエキス)、デンプン(コメ、トウモロコシ、バレイショ、コムギ)、グリチルリチン酸等の植物系高分子、キサンタンガム、デキストラン、サクシノグルカン、プルラン等の微生物系高分子、コラーゲン、カゼイン、アルブミン、ゼラチン等の動物系高分子を挙げることができる。 The natural water-soluble polymer is not particularly limited, and examples thereof include gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince seed), arge colloid (cassius extract), starch (rice, Corn, potato, wheat), plant-based polymers such as glycyrrhizic acid, microbial-based polymers such as xanthan gum, dextran, succinoglucan, pullulan, and animal-based polymers such as collagen, casein, albumin, and gelatin. ..
半合成の水溶性高分子としては特に限定されず、例えば、カルボキシメチルデンプン、メチルヒドロキシプロピルデンプン等のデンプン系高分子、メチルセルロース、ニトロセルロース、エチルセルロース、メチルヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、セルロース硫酸ナトリウム、ヒドロキシプロピルセルロース、カルボキシメチルセルロースナトリウム(CMC)、結晶セルロース、セルロース末等のセルロース系高分子、アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル等のアルギン酸系高分子等が挙げられる。 The semi-synthetic water-soluble polymer is not particularly limited, for example, carboxymethyl starch, starch-based polymers such as methyl hydroxypropyl starch, methyl cellulose, nitrocellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, Examples thereof include cellulosic polymers such as hydroxypropyl cellulose, sodium carboxymethyl cellulose (CMC), crystalline cellulose and cellulose powder, and alginic acid polymers such as sodium alginate and propylene glycol alginate.
合成の水溶性高分子としては特に限定されず、例えば、ポリビニルアルコール、ポリビニルメチルエーテル、ポリビニルピロリドン等のビニル系高分子、ポリエチレングリコール20000、40000、60000等のポリオキシエチレン系高分子、ポリオキシエチレンポリオキシプロピレン共重合体共重合系高分子、ポリアクリル酸ナトリウム、ポリエチルアクリレート、ポリアクリルアミド等のアクリル系高分子、ポリエチレンイミン、カチオンポリマー等が挙げられる。 The synthetic water-soluble polymer is not particularly limited, and examples thereof include vinyl-based polymers such as polyvinyl alcohol, polyvinyl methyl ether, and polyvinylpyrrolidone, polyoxyethylene-based polymers such as polyethylene glycol 20000, 40000, 60000, and polyoxyethylene. Examples thereof include polyoxypropylene copolymer copolymer polymers, acrylic polymers such as sodium polyacrylate, polyethyl acrylate and polyacrylamide, polyethyleneimine, cationic polymers and the like.
無機の水溶性高分子としては特に限定されず、例えば、ベントナイト、ケイ酸A1Mg(ビーガム)、ラポナイト、ヘクトライト、無水ケイ酸等が挙げられる。 The inorganic water-soluble polymer is not particularly limited, and examples thereof include bentonite, silicate A1Mg (veegum), laponite, hectorite, and silicic acid anhydride.
紫外線遮蔽剤としては特に限定されず、例えば、パラアミノ安息香酸(以下PABAと略す)、PABAモノグリセリンエステル、N,N−ジプロポキシPABAエチルエステル、N,N−ジエトキシPABAエチルエステル、N,N−ジメチルPABAエチルエステル、N,N−ジメチルPABAブチルエステル等の安息香酸系紫外線遮蔽剤;ホモメンチル−N−アセチルアントラニレート等のアントラニル酸系紫外線遮蔽剤;アミルサリシレート、メンチルサリシレート、ホモメンチルサリシレート、オクチルサリシレート、フェニルサリシレート、ベンジルサリシレート、p−イソプロパノールフェニルサリシレート等のサリチル酸系紫外線遮蔽剤;オクチルシンナメート、エチル−4−イソプロピルシンナメート、メチル−2,5−ジイソプロピルシンナメート、エチル−2,4−ジイソプロピルシンナメート、メチル−2,4−ジイソプロピルシンナメート、プロピル−p−メトキシシンナメート、イソプロピル−p−メトキシシンナメート、イソアミル−p−メトキシシンナメート、2−エトキシエチル−p−メトキシシンナメート、シクロヘキシル−p−メトキシシンナメート、エチル−α−シアノ−β−フェニルシンナメート、2−エチルヘキシル−α−シアノ−β−フェニルシンナメート、グリセリルモノ−2−エチルヘキサノイル−ジパラメトキシシンナメート等のケイ皮酸系紫外線遮蔽剤;2,4−ジヒドロキシベンゾフェノン、2,2’−ジヒドロキシ−4−メトキシベンゾフェノン、2,2’−ジヒドロキシ−4,4’−ジメトキシベンゾフェノン、2,2’,4,4’−テトラヒドロキシベンゾフェノン、2−ヒドロキシ−4−メトキシベンゾフェノン、2−ヒドロキシ−4−メトキシ−4’−メチルベンゾフェノン、2−ヒドロキシ−4−メトキシベンゾフェノン−5−スルホン酸塩、4−フェニルベンゾフェノン、2−エチルヘキシル−4’−フェニル−ベンゾフェノン−2−カルボキシレート、2−ヒドロキシ−4−n−オクトキシベンゾフェノン、4−ヒドロキシ−3− カルボキシベンゾフェノン等のベンゾフェノン系紫外線遮蔽剤;3−(4’−メチルベンジリデン)−d,l−カンファー、3−ベンジリデン−d,l−カンファー、ウロカニン酸、ウロカニン酸エチルエステル、2−フェニル−5−メチルベンゾキサゾール、2,2’−ヒドロキシ−5−メチルフェニルベンゾトリアゾール、2−(2’−ヒドロキシ−5’−t−オクチルフェニル)ベンゾトリアゾール、2−(2’−ヒドロキシ−5’−メチルフェニル)ベンゾトリアゾール、ジベンザラジン、ジアニソイルメタン、4−メトキシ−4’−t−ブチルジベンゾイルメタン、5−(3,3−ジメチル−2−ノルボルニリデン)−3−ペンタン−2−オン等が挙げられる。 The ultraviolet shielding agent is not particularly limited, and examples thereof include paraaminobenzoic acid (hereinafter referred to as PABA), PABA monoglycerin ester, N,N-dipropoxy PABA ethyl ester, N,N-diethoxy PABA ethyl ester, N,N-dimethyl. Benzoic acid-based UV screening agents such as PABA ethyl ester and N,N-dimethyl PABA butyl ester; Anthranilic acid-based UV screening agents such as homomenthyl-N-acetylanthranilate; amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate , Phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, and other salicylic acid-based UV screening agents; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate Mate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p Cinnamic acid such as -methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetra Hydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl- Benzophenone-based UV screening agents such as 4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)- d,l-camphor, 3-benzylidene-d,l-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzo Triazole, 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole, 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4' Examples thereof include -t-butyldibenzoylmethane and 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one.
その他薬剤成分としては特に限定されず、例えば、ビタミンA油、レチノール、パルミチン酸レチノール、イノシット、塩酸ピリドキシン、ニコチン酸ベンジル、ニコチン酸アミド、ニコチン酸DL−α−トコフェロール、アルコルビン酸リン酸マグネシウム、2−O−α−D−グルコピラノシル−L−アスコルビン酸、ビタミンD2(エルゴカシフェロール)、dl−α−トコフェロール、酢酸dl−α−トコフェロール、パントテン酸、ビオチン等のビタミン類;エストラジオール、エチニルエストラジオール等のホルモン;アルギニン、アスパラギン酸、シスチン、システイン、メチオニン、セリン、ロイシン、トリプトファン等のアミノ酸;アラントイン、アズレン等の抗炎症剤、アルブチン等の美白剤、;タンニン酸等の収斂剤;L−メントール、カンフル等の清涼剤;や、イオウ、塩化リゾチーム、塩化ピリドキシン等が挙げられる。 Other drug ingredients are not particularly limited, and examples thereof include vitamin A oil, retinol, retinol palmitate, inosit, pyridoxine hydrochloride, benzyl nicotinate, nicotinamide, nicotinic acid DL-α-tocopherol, magnesium ascorbate phosphate, and 2 -O-α-D-glucopyranosyl-L-ascorbic acid, vitamin D2 (ergocasiferol), dl-α-tocopherol, dl-α-tocopherol acetate, vitamins such as pantothenic acid, biotin; estradiol, ethinyl estradiol, etc. Hormones; amino acids such as arginine, aspartic acid, cystine, cysteine, methionine, serine, leucine and tryptophan; anti-inflammatory agents such as allantoin and azulene; whitening agents such as arbutin; astringents such as tannic acid; L-menthol and camphor. Etc., and sulfur, lysozyme chloride, pyridoxine chloride and the like.
各種の抽出液としては特に限定されず、例えば、ドクダミエキス、オウバクエキス、メリロートエキス、オドリコソウエキス、カンゾウエキス、シャクヤクエキス、サボンソウエキス、ヘチマエキス、キナエキス、ユキノシタエキス、クララエキス、コウホネエキス、ウイキョウエキス、サクラソウエキス、バラエキス、ジオウエキス、レモンエキス、シコンエキス、アロエエキス、ショウブ根エキス、ユーカリエキス、スギナエキス、セージエキス、タイムエキス、茶エキス、海藻エキス、キューカンバーエキス、チョウジエキス、キイチゴエキス、メリッサエキス、ニンジンエキス、マロニエエキス、モモエキス、桃葉エキス、クワエキス、ヤグリマギクエキス、ハマメリスエキス、プラセンタエキス、胸腺抽出物、シルク抽出液、甘草エキス等が挙げられる。 The various extracts are not particularly limited and include, for example, Dokudami extract, psyllium extract, meliloth extract, odorophyllum extract, licorice extract, peony extract, saponsou extract, loofah extract, kina extract, snow crab extract, clara extract, kohone extract, fennel. Extract, primrose extract, rose extract, sage extract, lemon extract, shikon extract, aloe extract, ginger root extract, eucalyptus extract, horsetail extract, sage extract, thyme extract, tea extract, seaweed extract, cucumber extract, clove extract, raspberry extract, melissa extract. , Carrot extract, horse chestnut extract, peach extract, peach leaf extract, mulberry extract, corn extract, hamamelis extract, placenta extract, thymus extract, silk extract, licorice extract and the like.
各種粉体としては、例えば、ベンガラ、黄酸化鉄、黒酸化鉄、雲母チタン、酸化鉄被覆雲母チタン、酸化チタン被覆ガラスフレーク等の光輝性着色顔料、マイカ、タルク、カオリン、セリサイト、二酸化チタン、シリカ等の無機粉末やポリエチレン末、ナイロン末、架橋ポリスチレン、セルロースパウダー、シリコーン末等の有機粉末等が挙げられる。好ましくは、官能特性向上や化粧持続性向上のため、粉末成分の一部又は全部をシリコーン類、フッ素化合物、金属石鹸、油剤、アシルグルタミン酸塩等の物質にて、公知の方法で疎水化処理したものである。 Examples of various powders include bright red pigments such as red iron oxide, yellow iron oxide, black iron oxide, titanium mica, titanium oxide-coated mica titanium, titanium oxide-coated glass flakes, mica, talc, kaolin, sericite, titanium dioxide. Inorganic powders such as silica, polyethylene powder, nylon powder, crosslinked polystyrene, cellulose powder, and organic powders such as silicone powder. Preferably, a part or all of the powder component is subjected to a hydrophobic treatment by a known method with a substance such as silicones, a fluorine compound, a metal soap, an oil agent, and an acylglutamate in order to improve the organoleptic properties and the durability of makeup. It is a thing.
本発明を詳細に説明するために以下に実施例を挙げるが、本発明はこれらの実施例のみに限定されるものではない。特に断りのない限り、「%」とは「重量%(質量%)」を意味する。 The following examples are given to explain the present invention in detail, but the present invention is not limited to these examples. Unless otherwise specified, “%” means “% by weight (% by mass)”.
実施例1
(1)中和
硫酸亜鉛7水和物96.6gと、354g/Lの硫酸アルミニウム水溶液81.2mL(Al2(SO4)3として28.7g)を混合し、全量が350mLとなるようにイオン交換水を加えた金属塩混合水溶液を得た。別途、720g/Lの水酸化ナトリウム水溶液46.7mLと、炭酸ナトリウム26.7gとを混合し、全量が350mLとなるようにイオン交換水を加えたアルカリ混合水溶液を得た。1Lの丸底フラスコにイオン交換水50mLを入れ、撹拌下において、これら水溶液を加えた。このときのスラリーのpHは9であった。その後、50℃で30分間撹拌することにより、スラリーを得た。Example 1
(1) Mixing 96.6 g of neutralized zinc sulfate heptahydrate and 81.2 mL of 354 g/L aluminum sulfate aqueous solution (28.7 g as Al 2 (SO 4 ) 3 ) so that the total amount becomes 350 mL. A metal salt mixed aqueous solution to which ion-exchanged water was added was obtained. Separately, 46.7 mL of a 720 g/L sodium hydroxide aqueous solution was mixed with 26.7 g of sodium carbonate to obtain an alkaline mixed aqueous solution in which ion-exchanged water was added so that the total amount became 350 mL. 50 mL of ion-exchanged water was put into a 1 L round bottom flask, and these aqueous solutions were added under stirring. The pH of the slurry at this time was 9. Then, a slurry was obtained by stirring at 50° C. for 30 minutes.
(2)乾燥・粉砕
上記「(1)中和」により得られたスラリーをろ過し、洗液の電気伝導度が100μS/cm以下になるまで水洗した。得られたケーキを105℃の温度で18時間乾燥し、乾燥粉5gをフォースミル(大阪ケミカル社製、FM−1)にて20秒間粉砕することにより、ハイドロタルサイト前駆体の粉末を得た。(2) Drying and pulverization The slurry obtained by the above "(1) Neutralization" was filtered and washed with water until the electric conductivity of the washing liquid became 100 µS/cm or less. The obtained cake was dried at a temperature of 105° C. for 18 hours, and 5 g of the dried powder was crushed with a force mill (FM-1 manufactured by Osaka Chemical Co., Ltd.) for 20 seconds to obtain a powder of a hydrotalcite precursor. ..
(5)湿潤雰囲気工程
上記「(2)乾燥・粉砕」により得られた粉末のうち1gを、口内径27mm、高さ15mmのガラスシャーレに入れて、恒温恒湿器(エスペック社製、PR−1KT)に入れ、室温から85℃、相対湿度85%RHまで15分間かけて調整し、85℃、相対湿度85%RHにて3時間保持し、その後ヒーターへの通電を中止し室温まで冷却した。なお、この工程は大気中で行った。このようにして、ハイドロタルサイト型粒子を含む粉末(1)を得た。(5) Wet atmosphere step 1 g of the powder obtained by the above-mentioned "(2) Drying/pulverization" was put in a glass petri dish having an inner diameter of 27 mm and a height of 15 mm, and a constant temperature and humidity chamber (manufactured by ESPEC Corp., PR- 1 KT) and adjust from room temperature to 85° C., relative humidity 85% RH over 15 minutes, hold at 85° C. and relative humidity 85% RH for 3 hours, then stop energizing the heater and cool to room temperature. .. Note that this step was performed in the atmosphere. Thus, powder (1) containing hydrotalcite-type particles was obtained.
実施例2〜6
実施例1において、「(5)湿潤雰囲気工程」での保持時間を表1に示すとおりに変更したこと以外は、実施例1と同様にしてハイドロタルサイト型粒子を含む粉末(2)〜(6)を各々得た。Examples 2-6
In Example 1, except that the holding time in "(5) Wet atmosphere step" was changed as shown in Table 1, powder (2) to (() containing hydrotalcite-type particles was prepared in the same manner as in Example 1. 6) were obtained respectively.
実施例7〜11
実施例1において、「(1)中和」での反応時間(すなわち50℃での撹拌時間)を10分とし、かつ「(5)湿潤雰囲気工程」での保持時間を表1に示すとおりに変更したこと以外は、実施例1と同様にしてハイドロタルサイト型粒子を含む粉末(7)〜(11)を各々得た。Examples 7-11
In Example 1, the reaction time in “(1) Neutralization” (that is, stirring time at 50° C.) was 10 minutes, and the retention time in “(5) Wet atmosphere step” was as shown in Table 1. Powders (7) to (11) containing hydrotalcite-type particles were obtained in the same manner as in Example 1 except that they were changed.
実施例12
実施例10の「(1)中和」により得られたハイドロタルサイト前駆体スラリーをろ過し、洗液の電気伝導度が100μS/cm以下になるまで水洗した。得られたケーキ3.3g(固形分30%)を「(5)湿潤雰囲気工程」に供する際は表1の通りとした。このようにしてハイドロタルサイト型粒子を含む粉末(12)を得た。Example 12
The hydrotalcite precursor slurry obtained by “(1) Neutralization” of Example 10 was filtered and washed with water until the electric conductivity of the washing liquid became 100 μS/cm or less. When the obtained cake (3.3 g, solid content: 30%) was subjected to "(5) Wet atmosphere step", the results are shown in Table 1. Thus, powder (12) containing hydrotalcite-type particles was obtained.
実施例13、14
(3)熟成
実施例7の「(1)中和」により得られたスラリーを、スラリー中の固形分換算で42gとなるように1Lの丸底フラスコに計り取り、全量が600mLとなるようにイオン交換水を加えた後、50℃で22時間撹拌した。このスラリーをろ過し、洗液の電気伝導度が100μS/cm以下になるまで水洗した。得られたケーキを、105℃の温度で18時間乾燥し、乾燥粉5gをフォースミル(大阪ケミカル社製、FM−1)にて20秒間粉砕することにより、ハイドロタルサイト前駆体の粉末を得た。得られた粉末のうち1gを、実施例1の「(5)湿潤雰囲気工程」に供した(但し、保持時間は表1に記載のとおりに変更した)。このようにしてハイドロタルサイト型粒子を含む粉末(13)、(14)を各々得た。Examples 13 and 14
(3) Aging The slurry obtained by "(1) Neutralization" of Example 7 was weighed into a 1 L round bottom flask so that the solid content in the slurry was 42 g, and the total amount was 600 mL. After adding ion-exchanged water, the mixture was stirred at 50° C. for 22 hours. This slurry was filtered and washed with water until the electric conductivity of the washing liquid became 100 μS/cm or less. The obtained cake was dried at a temperature of 105° C. for 18 hours, and 5 g of the dried powder was pulverized with a force mill (FM-1 by Osaka Chemical Co., Ltd.) for 20 seconds to obtain a powder of hydrotalcite precursor. It was 1 g of the obtained powder was subjected to the "(5) wet atmosphere step" of Example 1 (however, the holding time was changed as described in Table 1). Thus, powders (13) and (14) containing hydrotalcite-type particles were obtained.
比較例1
(1)中和
297g/Lの硫酸マグネシウム7水和物136.2mL(MgSO4として40.5g)と、354g/Lの硫酸アルミニウム水溶液81.2mL(Al2(SO4)3として28.7g)を混合し、全量が350mLとなるようにイオン交換水を加えた金属塩混合水溶液を得た。別途、720g/Lの水酸化ナトリウム水溶液46.7mLと、炭酸ナトリウム26.7gとを混合し、全量が350mLとなるようにイオン交換水を加えたアルカリ混合水溶液を得た。1Lの丸底フラスコにイオン交換水50mLを入れ、撹拌下において、これら水溶液を加えた。このときのスラリーのpHは9であった。その後、50℃で30分間撹拌することにより、ハイドロタルサイト前駆体のスラリーを得た。Comparative Example 1
(1) Neutralization 297 g/L magnesium sulfate heptahydrate 136.2 mL (40.5 g as MgSO 4 ) and 354 g/L aluminum sulfate aqueous solution 81.2 mL (Al 2 (SO 4 ) 3 as 28.7 g) ) Were mixed to obtain a metal salt mixed aqueous solution to which ion-exchanged water was added so that the total amount became 350 mL. Separately, 46.7 mL of a 720 g/L sodium hydroxide aqueous solution was mixed with 26.7 g of sodium carbonate to obtain an alkaline mixed aqueous solution in which ion-exchanged water was added so that the total amount became 350 mL. 50 mL of ion-exchanged water was put into a 1 L round bottom flask, and these aqueous solutions were added under stirring. The pH of the slurry at this time was 9. Then, the slurry of the hydrotalcite precursor was obtained by stirring at 50° C. for 30 minutes.
(2)乾燥・粉砕
上記「(1)中和」により得られたスラリーをろ過し、洗液の電気伝導度が100μS/cm以下になるまで水洗した。得られたケーキを105℃の温度で18時間乾燥し、乾燥粉5gをフォースミル(大阪ケミカル社製、FM−1)にて20秒間粉砕することにより、ハイドロタルサイト前駆体の粉末を得た。得られた粉末のうち1gを、実施例1の「(5)湿潤雰囲気工程」に供した(但し、保持時間は表2に示すとおりに変更した)。このようにしてハイドロタルサイト型粒子を含む粉末(c1)を得た。(2) Drying and pulverization The slurry obtained by the above "(1) Neutralization" was filtered and washed with water until the electric conductivity of the washing liquid became 100 µS/cm or less. The obtained cake was dried at a temperature of 105° C. for 18 hours, and 5 g of the dried powder was crushed with a force mill (FM-1 manufactured by Osaka Chemical Co., Ltd.) for 20 seconds to obtain a powder of a hydrotalcite precursor. .. 1 g of the obtained powder was subjected to the "(5) wet atmosphere step" of Example 1 (however, the holding time was changed as shown in Table 2). Thus, powder (c1) containing hydrotalcite-type particles was obtained.
比較例2
比較例1において、「(1)中和」で用いたMg原料を表2に示すZn原料及びMg原料に変更したこと以外は、比較例1と同様にして得たスラリーをろ過し、洗液の電気伝導度が100μS/cm以下になるまで水洗した。得られたケーキを、105℃の温度で18時間乾燥し、乾燥粉5gをフォースミル(大阪ケミカル社製、FM−1)にて20秒間粉砕することにより、ハイドロタルサイト前駆体の粉末を得た。得られた粉末のうち1gを、実施例1の「(5)湿潤雰囲気工程」に供した(但し、保持時間は表2に示すとおりに変更した)。このようにしてハイドロタルサイト型粒子を含む粉末(c2)を得た。Comparative example 2
In Comparative Example 1, the slurry obtained in the same manner as in Comparative Example 1 was filtered except that the Mg raw material used in “(1) Neutralization” was changed to the Zn raw material and the Mg raw material shown in Table 2 to obtain a washing liquid. It was washed with water until the electric conductivity of was less than 100 μS/cm. The obtained cake was dried at a temperature of 105° C. for 18 hours, and 5 g of the dried powder was pulverized with a force mill (FM-1 by Osaka Chemical Co., Ltd.) for 20 seconds to obtain a powder of hydrotalcite precursor. It was 1 g of the obtained powder was subjected to the "(5) wet atmosphere step" of Example 1 (however, the holding time was changed as shown in Table 2). Thus, powder (c2) containing hydrotalcite-type particles was obtained.
比較例3
実施例1において、「(5)湿潤雰囲気工程」を行わなかったこと以外は、実施例1と同様にして、ハイドロタルサイト型粒子を含む粉末(c3)を得た。Comparative Example 3
A powder (c3) containing hydrotalcite-type particles was obtained in the same manner as in Example 1 except that the "(5) wet atmosphere step" was not performed.
比較例4、6
実施例1において、「(1)中和」で用いたZn原料を表2に示すZn原料及びMg原料に変更し、かつ「(5)湿潤雰囲気工程」を行わなかったこと以外は、実施例1と同様にして、ハイドロタルサイト型粒子を含む粉末(c4)、(c6)を各々得た。Comparative Examples 4 and 6
In Example 1, except that the Zn raw material used in “(1) Neutralization” was changed to the Zn raw material and Mg raw material shown in Table 2, and “(5) Wet atmosphere step” was not performed. In the same manner as in 1, powders (c4) and (c6) containing hydrotalcite-type particles were obtained.
比較例5、7
実施例1において、「(1)中和」で用いたZn原料を表2に示すZn原料及びMg原料に変更し、かつ「(5)湿潤雰囲気工程」での相対湿度及び保持時間を表2に記載のとおりに変更したこと以外は、実施例1と同様にしてハイドロタルサイト型粒子を含む粉末(c5)、(c7)を各々得た。Comparative Examples 5 and 7
In Example 1, the Zn raw material used in “(1) Neutralization” was changed to the Zn raw material and the Mg raw material shown in Table 2, and the relative humidity and the holding time in “(5) Wet atmosphere step” are shown in Table 2. Powders (c5) and (c7) containing hydrotalcite-type particles were obtained in the same manner as in Example 1 except that the changes were made as described in (1).
比較例8、10〜12
実施例1において、「(5)湿潤雰囲気工程」での温度、相対湿度及び保持時間を表2に示すとおりに変更したこと以外は、実施例1と同様にしてハイドロタルサイト型粒子を含む粉末(c8)、(c10)〜(c12)を各々得た。Comparative Examples 8 and 10-12
A powder containing hydrotalcite-type particles in the same manner as in Example 1 except that the temperature, relative humidity and holding time in "(5) Wet atmosphere step" were changed as shown in Table 2. (C8) and (c10) to (c12) were obtained.
比較例9
(4)水熱
実施例1の「(1)中和」により得られたスラリーを、スラリー中の固形分換算で5.3gとなるように100mLの圧力容器に計り取り、全量が75mLとなるようにイオン交換水を加えた後、180℃で2時間保持した。このスラリーをろ過し、洗液の電気伝導度が100μS/cm以下になるまで水洗することにより、ケーキを得た。得られたケーキを、105℃の温度で18時間乾燥し、乾燥粉5gをフォースミル(大阪ケミカル社製、FM−1)にて20秒粉砕することにより、粉末(c9)を得たが、大半が酸化亜鉛であったため、後述の評価を行わなかった。Comparative Example 9
(4) Hydrothermal The slurry obtained by "(1) Neutralization" of Example 1 was weighed into a 100 mL pressure vessel so that the solid content in the slurry was 5.3 g, and the total amount was 75 mL. After adding ion-exchanged water, the mixture was kept at 180° C. for 2 hours. This slurry was filtered and washed with water until the electric conductivity of the washing liquid became 100 μS/cm or less, to obtain a cake. The obtained cake was dried at a temperature of 105° C. for 18 hours, and 5 g of the dried powder was crushed with a force mill (FM-1 manufactured by Osaka Chemical Co., Ltd.) for 20 seconds to obtain a powder (c9). Since the majority was zinc oxide, the later-described evaluation was not performed.
比較例13
(1)中和
硫酸亜鉛7水和物96.6gと、354g/Lの硫酸アルミニウム水溶液81.2mL(Al2(SO4)3として28.7g)を混合し、全量が350mLとなるようにイオン交換水を加えた金属塩混合水溶液を得た。別途、720g/Lの水酸化ナトリウム水溶液46.7mLと、炭酸ナトリウム26.7gとを混合し、全量が350mLとなるようにイオン交換水を加えたアルカリ混合水溶液を得た。1Lの丸底フラスコにイオン交換水50mLを入れ、撹拌下において、これら水溶液を加えた。このときのスラリーのpHは9であった。その後、50℃で10分間撹拌することにより、スラリーを得た。Comparative Example 13
(1) Mixing 96.6 g of neutralized zinc sulfate heptahydrate and 81.2 mL of 354 g/L aluminum sulfate aqueous solution (28.7 g as Al 2 (SO 4 ) 3 ) so that the total amount becomes 350 mL. A metal salt mixed aqueous solution to which ion-exchanged water was added was obtained. Separately, 46.7 mL of a 720 g/L sodium hydroxide aqueous solution was mixed with 26.7 g of sodium carbonate to obtain an alkaline mixed aqueous solution in which ion-exchanged water was added so that the total amount became 350 mL. 50 mL of ion-exchanged water was put into a 1 L round bottom flask, and these aqueous solutions were added under stirring. The pH of the slurry at this time was 9. Then, a slurry was obtained by stirring at 50° C. for 10 minutes.
(3)熟成
上記「(1)中和」により得られたスラリーを、スラリー中の固形分換算で42gとなるように1Lの丸底フラスコに計り取り、全量が600mLとなるようにイオン交換水を加えた後、50℃で22時間撹拌した。このスラリーをろ過し、洗液の電気伝導度が100μS/cm以下になるまで水洗した。得られたケーキを、105℃の温度で18時間乾燥し、乾燥粉5gをフォースミル(大阪ケミカル社製、FM−1)にて20秒間粉砕することにより、ハイドロタルサイト型粒子を含む粉末(c13)を得た。(3) Aging The slurry obtained by the above "(1) Neutralization" was weighed into a 1 L round bottom flask so that the solid content in the slurry was 42 g, and ion-exchanged water was added so that the total amount became 600 mL. After adding, the mixture was stirred at 50° C. for 22 hours. This slurry was filtered and washed with water until the electric conductivity of the washing liquid became 100 μS/cm or less. The obtained cake was dried at a temperature of 105° C. for 18 hours, and 5 g of the dried powder was pulverized with a force mill (FM-1 manufactured by Osaka Chemical Co., Ltd.) for 20 seconds to obtain a powder containing hydrotalcite-type particles ( c13) was obtained.
比較例14
実施例7において、「(5)湿潤雰囲気工程」を行わなかったこと以外は、実施例7と同様にして、ハイドロタルサイト型粒子を含む粉末(c14)を得た。Comparative Example 14
A powder (c14) containing hydrotalcite-type particles was obtained in the same manner as in Example 7, except that the "(5) wet atmosphere step" was not performed.
比較例15
比較例13において、「(3)熟成」での熟成温度(50℃)を85℃に変更したこと以外は、比較例13と同様にして、ケーキを得た。得られたケーキを、105℃の温度で18時間乾燥し、乾燥粉5gをフォースミル(大阪ケミカル社製、FM−1)にて20秒間粉砕することにより、ハイドロタルサイト型粒子を含む粉末(c15)を得た。Comparative Example 15
A cake was obtained in the same manner as in Comparative Example 13 except that the aging temperature (50° C.) in “(3) Aging” in Comparative Example 13 was changed to 85° C. The obtained cake was dried at a temperature of 105° C. for 18 hours, and 5 g of the dried powder was pulverized with a force mill (FM-1 manufactured by Osaka Chemical Co., Ltd.) for 20 seconds to obtain a powder containing hydrotalcite-type particles ( c15) was obtained.
比較例16、17
比較例15の「(3)熟成」で得たハイドロタルサイトの粉末のうち1gを、実施例1の「(5)湿潤雰囲気工程」に供した(但し、保持時間は表2に示すとおりに変更した)。このようにしてハイドロタルサイト型粒子を含む粉末(c16)、(c17)を各々得た。Comparative Examples 16 and 17
1 g of the hydrotalcite powder obtained in "(3) Aging" of Comparative Example 15 was subjected to "(5) Wet atmosphere step" of Example 1 (however, the holding time is as shown in Table 2). changed). Thus, powders (c16) and (c17) containing hydrotalcite-type particles were obtained.
比較例18
比較例13において、「(3)熟成」での熟成温度(50℃)を100℃に変更したこと以外は、比較例13と同様にして、ケーキを得た。得られたケーキを、105℃の温度で18時間乾燥し、乾燥粉5gをフォースミル(大阪ケミカル社製、FM−1)にて20秒間粉砕することにより、ハイドロタルサイト型粒子を含む粉末(c18)を得た。Comparative Example 18
A cake was obtained in the same manner as in Comparative Example 13 except that the aging temperature (50° C.) in “(3) Aging” in Comparative Example 13 was changed to 100° C. The obtained cake was dried at a temperature of 105° C. for 18 hours, and 5 g of the dried powder was pulverized with a force mill (FM-1 manufactured by Osaka Chemical Co., Ltd.) for 20 seconds to obtain a powder containing hydrotalcite-type particles ( c18) was obtained.
参考例1
参考のため、市販品であるハイドロタルサイト類化合物(STABIACE・HT−1−NC、(Mg)0.67(Al)0.33(OH)2(CO3 2−)0.17・0.5H2O、堺化学工業社製)を、参考例1の粉末(参考例1で得たハイドロタルサイト型粒子)とした。Reference example 1
For reference, the hydrotalcite compound is a commercial product (STABIACE · HT-1-NC , (Mg) 0.67 (Al) 0.33 (OH) 2 (CO 3 2-) 0.17 · 0. 5H 2 O manufactured by Sakai Chemical Industry Co., Ltd. was used as the powder of Reference Example 1 (hydrotalcite-type particles obtained in Reference Example 1).
各実施例及び比較例で得たハイドロタルサイト型粒子(粉体)、並びに、「(5)湿潤雰囲気工程」に供する際の前駆体(「(5)湿潤雰囲気工程」を行わない場合は生成物)について、以下の方法に従って、それぞれ、物性の測定と評価を行った。 The hydrotalcite-type particles (powder) obtained in each of the examples and comparative examples, and a precursor for use in the "(5) wet atmosphere step" (produced when the "(5) wet atmosphere step" is not performed) The physical properties of each product were measured and evaluated according to the following methods.
1、半価幅の測定
得られた各粉体について、以下の条件により粉末X線回折パターン(単にX線回折パターンともいう)を測定した。例えば、実施例11で得た粉体のX線回折パターンを図1に示す。その後、得られた各粉体のX線回折の測定により得られた回折パターンから、(003)及び(006)半価幅を測定した。結果を表3及び4に示す。
なお、実施例で得た全ての粉体のX線回折パターンは、JCPDSカード 00−048−1023と一致した。1. Measurement of full width at half maximum The powder X-ray diffraction pattern (also simply referred to as X-ray diffraction pattern) of each of the obtained powders was measured under the following conditions. For example, the X-ray diffraction pattern of the powder obtained in Example 11 is shown in FIG. Then, the (003) and (006) half widths were measured from the diffraction patterns obtained by the X-ray diffraction measurement of the obtained powders. The results are shown in Tables 3 and 4.
The X-ray diffraction patterns of all the powders obtained in the examples were in agreement with those of JCPDS card 00-048-1023.
−分析条件−
使用機:リガク社製 RINT−UltimaIII
線源:CuKα
電圧:50kV
電流:300mA
試料回転速度:60rpm
発散スリット:1.00mm
発散縦制限スリット:10mm
散乱スリット:開放
受光スリット:開放
走査モード:FT
計数時間:2.0秒
ステップ幅:0.0200°
操作軸:2θ/θ
走査範囲:1.6000〜70.0000°
積算回数:1回
ハイドロタルサイト型粒子の同定に用いたのは以下の資料である。
Zn0.67Al0.33(OH)2(CO3)0.165・xH2O:JCPDSカード 00−048−1023
Mg4Al2(OH)12CO3・3H2O:JCPDSカード 00−051−1525
なお、線源としてCuKα線を用いたX線回折において、ハイドロタルサイトの最大ピークである(003)面に由来するピークは2θ=11.6°付近に、(006)面に由来するピークは2θ=23.4°付近にある。-Analysis conditions-
Machine used: Rigaku Corporation RINT-Ultima III
Radiation source: CuKα
Voltage: 50kV
Current: 300mA
Sample rotation speed: 60 rpm
Divergence slit: 1.00mm
Divergence vertical restriction slit: 10 mm
Scattering slit: Open Receiving slit: Open Scanning mode: FT
Counting time: 2.0 seconds Step width: 0.0200°
Operation axis: 2θ/θ
Scanning range: 1.6000 to 70.0000°
Number of times of integration: 1 time The following materials were used to identify the hydrotalcite-type particles.
Zn 0.67 Al 0.33 (OH) 2 (CO 3) 0.165 · xH 2 O: JCPDS card 00-048-1023
Mg 4 Al 2 (OH) 12 CO 3 · 3H 2 O: JCPDS Card 00-051-1525
In X-ray diffraction using CuKα rays as a radiation source, the peak derived from the (003) plane, which is the maximum peak of hydrotalcite, is around 2θ=11.6°, and the peak derived from the (006) plane is It is in the vicinity of 2θ=23.4°.
2、比表面積(SSA)の測定
以下の条件により比表面積(SSA)の測定を行った。結果を表3及び4に示す。
使用機:マウンテック社製、Macsorb Model HM−1220
雰囲気:窒素ガス(N2)
外部脱気装置の脱気条件:105℃−15分
比表面積測定装置本体の脱気条件:105℃−5分2. Measurement of specific surface area (SSA) The specific surface area (SSA) was measured under the following conditions. The results are shown in Tables 3 and 4.
Machine used: Mounttech, Macsorb Model HM-1220
Atmosphere: Nitrogen gas (N 2 )
Degassing conditions of external degassing equipment: 105°C-15 minutes Degassing conditions of main body of specific surface area measuring equipment: 105°C-5 minutes
3、メジアン径(D50)及び粒度分布のシャープさ(D90/D10)
レーザー回折・散乱式粒度分析計(HORIBA社製、型番:LA−950−V2)により粒度分布測定を行った。
まずサンプル(試料粉体)0.1gに0.025wt%ヘキサメタリン酸ナトリウム水溶液60mLを加え、超音波ホモジナイザー(US−600、日本精機製作所製)を用いて、強度をV−LEVEL3に設定して2分間分散処理を行うことにより、サンプルの懸濁液を準備した。この後、0.025wt%ヘキサメタリン酸ナトリウム水溶液を試料循環器に循環させ、透過率が80〜95%になるように上記懸濁液を滴下して、循環速度5、撹拌速度1にて、60秒間超音波分散してから測定を行った。結果を表3及び4に示す。3, median diameter (D 50 ) and sharpness of particle size distribution (D 90 /D 10 ).
The particle size distribution was measured with a laser diffraction/scattering particle size analyzer (manufactured by HORIBA, model number: LA-950-V2).
First, 60 mL of 0.025 wt% sodium hexametaphosphate aqueous solution was added to 0.1 g of a sample (sample powder), and the strength was set to V-LEVEL3 by using an ultrasonic homogenizer (US-600, manufactured by Nippon Seiki Seisakusho Co., Ltd.). A sample suspension was prepared by performing a dispersion treatment for a minute. Then, a 0.025 wt% sodium hexametaphosphate aqueous solution was circulated in the sample circulator, the suspension was added dropwise so that the transmittance was 80 to 95%, and the circulation speed was 5 and the stirring speed was 1 at 60%. The measurement was performed after ultrasonic dispersion for 2 seconds. The results are shown in Tables 3 and 4.
4、元素分析
ハイドロタルサイト中のMg,Zn,Al含有量は、誘導結合プラズマ(ICP)発光分光分析法を用い、以下の方法により測定することができる。
具体的には、以下のように、分光器(SII社製、ICP SPS3100)を使用し、スカンジウム(Sc)を内標準元素とする内標準法により測定する。
まず、試料約0.2gをビーカーに精秤し、塩酸約5mLを加えて溶解させ、100mLメスフラスコに充填し、イオン交換水でメスアップする。これをMg含有量測定では20倍、Zn含有量測定では50倍、Al含有量測定では10倍希釈し、かつSc濃度が10ppmとなるようにSc標準溶液を添加した溶液を試験液とし、下記の測定条件により測定し、得られた生データを下記の計算条件で計算することによりMg,Zn,Al含有量を算出する。結果を表3及び4に示す。4. Elemental analysis The Mg, Zn, Al content in hydrotalcite can be measured by the following method using inductively coupled plasma (ICP) emission spectroscopy.
Specifically, the spectroscope (ICP SPS3100, manufactured by SII) is used as follows, and the measurement is performed by an internal standard method using scandium (Sc) as an internal standard element.
First, about 0.2 g of a sample is precisely weighed in a beaker, about 5 mL of hydrochloric acid is added to dissolve it, the solution is filled in a 100 mL volumetric flask, and the volume is increased with ion-exchanged water. This was diluted 20 times in Mg content measurement, 50 times in Zn content measurement, and 10 times in Al content measurement, and a test solution was prepared by adding a Sc standard solution so that the Sc concentration was 10 ppm. The Mg, Zn, and Al contents are calculated by calculating the raw data obtained under the following measurement conditions. The results are shown in Tables 3 and 4.
−測定条件−
分光器(SII社製、ICP SPS3100)を使用し、波長279.55nm(Mg)、213.86nm(Zn)、396.15nm(Al)、361.49nm(Sc)にてそれぞれ検量線を作成した後、試料を測定する。
検量線用試料の濃度としては、
Mg(ppm)=50,40,30,20,10、
Zn(ppm)=20,16,12,8,4、
Al(ppm)=50,40,30,20,10
の各5点を使用する。
なお、いずれの検量線用試料も、Sc濃度が10ppmとなるようにSc標準溶液を添加した。計算条件は以下の通りである。
各含有量(%)=生データ×100/試料重量(g)×希釈倍率/10000-Measurement conditions-
Using a spectroscope (ICP SPS3100, manufactured by SII), calibration curves were created at wavelengths 279.55 nm (Mg), 213.86 nm (Zn), 396.15 nm (Al) and 361.49 nm (Sc), respectively. After that, the sample is measured.
As the concentration of the sample for the calibration curve,
Mg (ppm)=50, 40, 30, 20, 10,
Zn (ppm)=20, 16, 12, 8, 4,
Al (ppm)=50, 40, 30, 20, 10
5 points each are used.
Note that the Sc standard solution was added to each of the calibration curve samples so that the Sc concentration was 10 ppm. The calculation conditions are as follows.
Each content (%)=raw data×100/sample weight (g)×dilution ratio/10000
また、以上のように求めたMg,Zn,Al含有量(重量%)を用い、下記計算式;
x=(Al含有量/26.982)÷{(Mg含有量/24.305)+(Zn含有量/65.38)+(Al含有量/26.982)}
により、上記式(1)中のxに該当する値を求めた。結果を表3及び4に示す。Further, using the Mg, Zn, and Al contents (% by weight) obtained as described above, the following calculation formula;
x=(Al content/26.982)/{(Mg content/24.305)+(Zn content/65.38)+(Al content/26.982)}
Thus, the value corresponding to x in the above formula (1) was determined. The results are shown in Tables 3 and 4.
5、細孔容積
自動比表面積/細孔分布測定装置(製品名「BEL SORP−miniII」、日本ベル社製)を用いて測定した。サンプル0.1gを測定セルに充填し、200℃にて脱ガス処理を行った後に測定を行った。
平均細孔直径、全細孔容積及び細孔分布を算出するための解析法は、BJH法を用いる。
平均細孔直径とは、全細孔容積の4倍を表面積で除した値のことを示す。これはサンプル中のすべての細孔を円筒形であると仮定し、その円筒型細孔が体積Vだとする。このとき円筒型細孔の体積は以下の式(i)で表される。
V=πD2L/4 (i)
式中、Dは細孔直径、Lは円筒型細孔の長さとする。
次に、円筒型細孔の側面積Aを以下の式(ii)で表す。
A=πDL (ii)
上記式(i)及び(ii)から、次の式(iii)が得られる。
D=4V/A (iii)
上記式(iii)で算出されたDを平均細孔直径とする。
全細孔容積は、BJH法による細孔分布結果から得た全範囲の細孔の積算値である。結果を表3及び4に示す。5. Pore volume Automatic specific surface area/pore distribution measuring device (product name “BEL SORP-miniII”, manufactured by Bell Japan Ltd.) was used. The measurement cell was filled with 0.1 g of a sample, and degassing was performed at 200° C., followed by measurement.
The BJH method is used as an analysis method for calculating the average pore diameter, the total pore volume, and the pore distribution.
The average pore diameter means a value obtained by dividing 4 times the total pore volume by the surface area. This assumes that all pores in the sample are cylindrical and that the cylindrical pores have a volume V. At this time, the volume of the cylindrical pore is represented by the following formula (i).
V=πD 2 L/4 (i)
In the formula, D is the pore diameter, and L is the length of the cylindrical pore.
Next, the side area A of the cylindrical pore is expressed by the following formula (ii).
A=πDL (ii)
From the above equations (i) and (ii), the following equation (iii) is obtained.
D=4V/A (iii)
Let D calculated by the above formula (iii) be the average pore diameter.
The total pore volume is an integrated value of pores in the entire range obtained from the result of pore distribution by the BJH method. The results are shown in Tables 3 and 4.
6、平均板面径、平均厚み及びアスペクト比
各粉体につき、電界放出型走査電子顕微鏡(日本電子社製、JSM−7000F)により、粒子が50〜10000個程度写るように電子顕微鏡写真を撮影した。この電子顕微鏡写真上に無作為に引いた直線上にある粒子20個の板面径の平均値を、各粉体の平均板面径とした。同様の方法で平均厚み(粒子20個の厚みの平均値)を算出し、(平均板面径/平均厚み)によってアスペクト比を求めた。板面径、厚みが測定しにくい場合は、適宜倍率を上げて撮影したものを用いて測定した。実施例、比較例毎に撮影する粉体を換えてこの操作を10回繰り返し、求めたアスペクト比の平均値を算出した。結果を表3及び4に示す。また、実施例で得た粉体について、平均板面径と平均厚みを算出した際、同時に平均板面径と平均厚みの標準偏差(平均値との差の2乗を平均した値の平方根)とその変動係数(標準偏差を平均値で割った値)を算出した。結果を表3に示す。6. Average plate surface diameter, average thickness, and aspect ratio For each powder, take an electron microscope photograph with a field emission scanning electron microscope (JSM-7000F, manufactured by JEOL Ltd.) so that about 50 to 10,000 particles can be seen. did. The average value of the plate surface diameters of 20 particles on a straight line drawn randomly on this electron micrograph was taken as the average plate surface diameter of each powder. The average thickness (average value of the thickness of 20 particles) was calculated by the same method, and the aspect ratio was calculated by (average plate surface diameter/average thickness). When it is difficult to measure the plate surface diameter and thickness, the platen diameter and the thickness were appropriately increased and photographed. This operation was repeated 10 times by changing the powder to be photographed in each of the Examples and Comparative Examples, and the average value of the obtained aspect ratios was calculated. The results are shown in Tables 3 and 4. Further, when the average plate surface diameter and the average thickness of the powders obtained in the examples are calculated, the standard deviations of the average plate surface diameter and the average thickness (the square root of the value obtained by averaging the square of the difference from the average value) at the same time. And its coefficient of variation (standard deviation divided by the average value) was calculated. The results are shown in Table 3.
7、顔料pH
各粉体の顔料pHを、「JIS K5101−17−1:2004」の顔料試験方法に準拠した以下の方法により測定した。
栓付ガラス容器に蒸留水50gに試料5gを投入し、栓を外したまま、約5分間加熱して煮沸状態にした後、更に5分間煮沸した。煮沸後、栓をして常温まで放冷した後、栓を開き、減量に相当する蒸留水を加えて、再び栓をして1分間振り混ぜた後、5分間静置した。栓を取り外し、pH測定器にてpHを測定した。結果を表3及び4に示す。7, pigment pH
The pigment pH of each powder was measured by the following method based on the pigment test method of "JIS K5101-17-1:2004".
A glass container with a stopper was charged with 5 g of a sample in 50 g of distilled water, and while the stopper was removed, the mixture was heated for about 5 minutes to be boiled, and then boiled for another 5 minutes. After boiling, the container was stoppered and allowed to cool to room temperature, the stopper was opened, distilled water corresponding to the weight loss was added, the stopper was capped again, and the mixture was shaken for 1 minute and left to stand for 5 minutes. The stopper was removed and the pH was measured with a pH meter. The results are shown in Tables 3 and 4.
8、吸油量
JIS K5101−13−1(2004年)に準拠した以下の方法で、ミリスチン酸イソプロピルを用い、吸油量を測定した。
試料約0.5gを薬包紙に精秤し、ガラス板の中央10cmのスリガラス部分に試料を載せる。ミクロビュレットにミリスチン酸イソプロピル(「IPM」と称す)を入れ、0.2mLを試料に滴加し、金ベラで練る。その後、IPMを1〜2滴ずつ加え、滴加の都度、全体を金ベラで練る。全体が初めて硬いパテ状の塊になったときを終点とする。
吸油量は次式によって算出した。結果を表3(及び4)に示す。
吸油量(ml/100g)= {V(mL)÷ 試料重量(g)}× 1008. Oil absorption amount The oil absorption amount was measured using isopropyl myristate by the following method based on JIS K5101-13-1 (2004).
About 0.5 g of the sample is precisely weighed on the medicine packing paper, and the sample is placed on the ground glass part of 10 cm in the center of the glass plate. Put isopropyl myristate (referred to as “IPM”) in a microburet, add 0.2 mL to the sample dropwise, and knead with a gold spatula. After that, 1 to 2 drops of IPM are added, and the whole is kneaded with a gold spatula at each addition. The end point is when the whole becomes a hard putty-like mass for the first time.
The oil absorption amount was calculated by the following formula. The results are shown in Table 3 (and 4).
Oil absorption (ml/100g) = {V (mL) ÷ sample weight (g)} x 100
9、滑り性(MIU、MMD)
各試料の滑り性評価は次のような方法で行った。
スライドガラスに両面テープを貼り付け、粘着面に薬さじ半分程度の粉末(試料)を載せ、化粧用スポンジで粉末を展ばし、その上に摩擦子をセットした。スライドガラスを移動させて、摩擦子にかかる負荷から、平均摩擦係数MIUと平均摩擦係数の変動値MMDを測定した。測定は摩擦感テスター(カトーテック製、KES−SE)により行った。
比較対象として、板状硫酸バリウム・H(堺化学工業社製)、及び、市販のハイドロタルサイト類化合物であるSTABIACE・HT−1NC(堺化学工業社製)(参考例1)を用いた。
板状硫酸バリウム・Hの平均摩擦係数MIUは0.64、平均摩擦係数の変動値MMDは0.0103であり、STABIACE・HT−1NCの平均摩擦係数MIUは0.897、平均摩擦係数の変動値MMDは0.047であった。
なお、平均摩擦係数MIUは、数値が小さいほど粉体が滑ることを示す指標であり、摩擦係数の変動値MMDは、数値が小さいほど滑らかでざらつきが無いことを示す指標である。結果を表3(及び4)に示す。9, slipperiness (MIU, MMD)
The slipperiness of each sample was evaluated by the following method.
A double-sided tape was attached to a slide glass, a powder (sample) of about half a spoon was placed on the adhesive surface, the powder was spread with a cosmetic sponge, and a friction element was set on it. The slide glass was moved, and the average friction coefficient MIU and the variation value MMD of the average friction coefficient were measured from the load applied to the friction element. The measurement was performed with a friction tester (KES-SE manufactured by Kato Tech).
As a comparison object, plate-shaped barium sulfate·H (manufactured by Sakai Chemical Industry Co., Ltd.) and STABACE HT-1NC (manufactured by Sakai Chemical Industry Co., Ltd.), which is a commercially available hydrotalcite compound (Reference Example 1), were used.
The average friction coefficient MIU of the plate-shaped barium sulfate·H is 0.64, the variation value MMD of the average friction coefficient is 0.0103, and the average friction coefficient MIU of STABIACE·HT-1NC is 0.897, the variation of the average friction coefficient. The value MMD was 0.047.
The average friction coefficient MIU is an index indicating that the powder slips as the numerical value is smaller, and the variation value MMD of the friction coefficient is an index indicating that the powder is smoother and less rough. The results are shown in Table 3 (and 4).
10、化粧料としての評価(官能評価)
(1)まず、実施例及び比較例で得たハイドロタルサイト20.00重量%、マイカ(製品名:Y−2300X、ヤマグチマイカ社製)24.83重量%、セリサイト(製品名:FSE、三信鉱工社製)29.79重量%、球状シリコーン(製品名:KSP-105、信越化学工業社製)6.44重量%、酸化チタン(製品名:R−3LD、堺化学工業社製)7.36重量%、酸化鉄(黄)(製品名:黄酸化鉄、ピノア社製)1.10重量%、酸化鉄(赤)(製品名:ベンガラ、ピノア社製)0.37重量%、金属石鹸(製品名:JPM−100、堺化学工業社製)0.92重量%、及び、オイル(製品名:KF96、信越化学工業社製)9.20重量%を、コーヒーミルを用いて1分30秒間撹拌混合した。
得られた粉体状の混合物を、直径20mmφの金型に0.8g測り採り、プレス機を用いて、200kgf/cm2の圧力にて30秒間保持して、ハイドロタルサイト含有ファンデーションを作製した。10, evaluation as cosmetics (sensory evaluation)
(1) First, 20.00% by weight of hydrotalcite obtained in Examples and Comparative Examples, mica (product name: Y-2300X, manufactured by Yamaguchi Mica Co., Ltd.) 24.83% by weight, sericite (product name: FSE, Sanshin Mining Co., Ltd.) 29.79% by weight, spherical silicone (product name: KSP-105, Shin-Etsu Chemical Co., Ltd.) 6.44% by weight, titanium oxide (product name: R-3LD, Sakai Chemical Co., Ltd.) 7.36% by weight, iron oxide (yellow) (product name: yellow iron oxide, manufactured by Pinoa) 1.10% by weight, iron oxide (red) (product name: red iron oxide, manufactured by Pinoa) 0.37% by weight, Using a coffee mill, 0.92% by weight of metal soap (product name: JPM-100, manufactured by Sakai Chemical Industry Co., Ltd.) and 9.20% by weight of oil (product name: KF96, manufactured by Shin-Etsu Chemical Co., Ltd.) were used. The mixture was stirred and mixed for 30 minutes.
0.8 g of the obtained powdery mixture was weighed in a mold having a diameter of 20 mm and held at a pressure of 200 kgf/cm 2 for 30 seconds using a press machine to prepare a hydrotalcite-containing foundation. ..
(2)また、比較として、マイカ(製品名:Y−2300X、ヤマグチマイカ社製)31.03重量%、セリサイト(製品名:FSE、三信鉱工社製)37.24重量%、球状シリコーン(製品名:KSP-105、信越化学工業社製)8.05重量%、酸化チタン(製品名:R−3LD、堺化学工業社製)9.20重量%、酸化鉄(黄)(製品名:黄酸化鉄、ピノア社製)1.38重量%、酸化鉄(赤)(製品名:ベンガラ、ピノア社製)0.46重量%、金属石鹸(製品名:JPM−100、堺化学工業社製)1.15重量%、及び、オイル(製品名:KF96、信越化学工業社製)11.49重量%を、コーヒーミルを用いて1分30秒間撹拌混合した。
得られた粉体状の混合物を、直径20mmφの金型に0.8g測り採り、プレス機を用いて、200kgf/cm2の圧力にて30秒間保持して、ハイドロタルサイト非含有ファンデーションを作製した。(2) For comparison, mica (product name: Y-2300X, manufactured by Yamaguchi Mica) 31.03% by weight, sericite (product name: FSE, manufactured by Sanshin Mining Co., Ltd.) 37.24% by weight, spherical silicone (Product name: KSP-105, manufactured by Shin-Etsu Chemical Co., Ltd.) 8.05% by weight, titanium oxide (Product name: R-3LD, manufactured by Sakai Chemical Industry Co., Ltd.) 9.20% by weight, iron oxide (yellow) (Product name) : Yellow iron oxide, manufactured by Pinoa Co., Ltd. 1.38% by weight, iron oxide (red) (product name: red iron oxide, manufactured by Pinoa Co., Ltd.) 0.46% by weight, metal soap (product name: JPM-100, Sakai Chemical Industry Co., Ltd.) 1.15% by weight of oil) and 11.49% by weight of oil (product name: KF96, manufactured by Shin-Etsu Chemical Co., Ltd.) were stirred and mixed for 1 minute 30 seconds using a coffee mill.
0.8 g of the obtained powdery mixture was weighed in a mold having a diameter of 20 mm and held at a pressure of 200 kgf/cm 2 for 30 seconds using a pressing machine to prepare a hydrotalcite-free foundation. did.
(3)上記(1)及び(2)それぞれで得たファンデーションを10人のパネラーに対して塗布し、化粧料に含めた際の肌への塗布感触について、以下に示す基準で選んでもらい評価した。なお、試験は盲検として行った。評価結果を表3及び表4に示す。
(塗布感触の評価基準)
◎:上記(1)のハイドロタルサイト含有ファンデーションを用いる方が、上記(2)のハイドロタルサイト非含有ファンデーションを用いるよりも塗布感触が良好である。
○: どちらも同じ塗布感触である。
×:上記(2)のハイドロタルサイト非含有ファンデーションを用いる方が、上記(1)のハイドロタルサイト含有ファンデーションを用いるよりも塗布感触が良好である。(3) The foundation obtained in each of the above (1) and (2) was applied to 10 panelists, and the application feeling to the skin when included in cosmetics was evaluated according to the following criteria. did. The test was conducted blindly. The evaluation results are shown in Tables 3 and 4.
(Evaluation criteria for feel of application)
⊚: The use of the hydrotalcite-containing foundation of (1) above gives a better coating feel than the use of (2) non-hydrotalcite-containing foundation.
◯: Both have the same application feeling.
X: The use of the hydrotalcite-free foundation of (2) above gives a better coating feel than the use of the hydrotalcite-containing foundation of (1) above.
11、SEM画像
電界放出形走査電子顕微鏡(日本電子社製、JSM−7000F)にて粒子の形状を観察した。実施例11で得た粉体の電子顕微鏡写真を図2−1〜2−4に示す。11. SEM image The shape of particles was observed with a field emission scanning electron microscope (JSM-7000F, manufactured by JEOL Ltd.). Electron micrographs of the powder obtained in Example 11 are shown in FIGS.
12、水溶液中のリン化合物吸着率
リン酸水素カリウムを用いて、リン酸イオン濃度を50,25,5ppmにそれぞれ調整した溶液100gに対し、試料を1g添加して所定の時間撹拌した後、ろ過した溶液のリン酸イオン濃度を、イオンクロマトグラフ(Dionex社製、型番:ICS−2000)にて測定した。実施例11で得た粉体を用いた場合について経時で測定したリン酸イオン濃度を、図3−1、3−2及び3−3に示す。これらの図面では、比較のため、参考例1の粉末を用いた場合の経時でのリン酸イオン濃度を併記した。
以下の式により、a時間経過後のブランクに対するリン化合物吸着率を算出した。
リン化合物吸着率(%)=100×(a時間経過後のブランクのリン酸イオン濃度−a時間経過後の評価サンプル(試料)のリン酸イオン濃度)/(a時間経過後のブランクのリン酸イオン濃度)
なお、a時間経過後のブランクのリン酸イオン濃度は、リン酸水素カリウムを用いてリン酸イオン濃度を50,25,5ppmに調整した溶液100gに、評価サンプルを入れずに所定の時間撹拌し、a時間経過した後のろ過した溶液のリン酸イオン濃度である。1時間経過後,2時間経過後,4時間経過後のブランクのリン酸イオン濃度は、それぞれ50ppm,25ppm,5ppmとなり、初期値と同じ値であった。12. Phosphorus compound adsorption rate in aqueous solution Potassium hydrogen phosphate was used to add 1 g of the sample to 100 g of the solution in which the phosphate ion concentration was adjusted to 50, 25, and 5 ppm, respectively, and the mixture was stirred for a predetermined time and then filtered. The phosphate ion concentration of the prepared solution was measured by an ion chromatograph (manufactured by Dionex, model number: ICS-2000). The phosphate ion concentrations measured over time when the powder obtained in Example 11 was used are shown in FIGS. 3-1, 3-2, and 3-3. In these drawings, for comparison, the phosphate ion concentration over time when the powder of Reference Example 1 was used is also shown.
The phosphorus compound adsorption rate to the blank after the lapse of time a was calculated by the following formula.
Phosphorus compound adsorption rate (%)=100×(Phosphate ion concentration of blank after a time has elapsed-Phosphate ion concentration of evaluation sample (sample) after a time has elapsed)/(Blank phosphoric acid after a time has elapsed) Ion concentration)
In addition, the phosphate ion concentration of the blank after the lapse of time a was agitated for a predetermined time without putting the evaluation sample in 100 g of the solution in which the phosphate ion concentration was adjusted to 50, 25.5 ppm using potassium hydrogen phosphate. , A phosphate ion concentration of the filtered solution after a time has elapsed. After 1 hour, 2 hours, and 4 hours, the blank phosphate ion concentrations were 50 ppm, 25 ppm, and 5 ppm, respectively, which were the same as the initial values.
13、アンモニアガス吸着率
各試料粉末1.0gを、5Lのサンプリングバック(GLサイエンス社製)に入れ、ブランクとしてサンプルを入れていない5Lのサンプリングバックも用意した。アンモニアを100ppm含む窒素ガス3Lをサンプリングバック内に注入した後、直ちに密封し、20℃、湿度65%の条件下で1時間静置した。静置後、サンプリングバック内のガス100mLを吸引器で吸入し、アンモニアの濃度をガステック社製検知管(No.3La)で測定した。実施例11で得た粉体を用いた場合のアンモニア濃度の経時変化を、図4に示す。図4では、比較のため、比較例18及び参考例1で得た粉末を用いた場合のアンモニア濃度の経時変化を併記した。
以下の式により、ブランクに対するアンモニアガス吸着率を算出した。
アンモニアガス吸着率(%)=100×(ブランクのアンモニア濃度−評価サンプルのアンモニア濃度)/(ブランクのアンモニア濃度)
なお、ブランクのアンモニア濃度は、評価サンプルを入れずに、アンモニアを100ppm含む窒素ガス3Lのみを入れたサンプリングバックを密栓し、1時間静置した後に測定したアンモニア濃度である。ブランクのアンモニア濃度は100ppmであった。13. Ammonia gas adsorption rate 1.0 g of each sample powder was put into a 5 L sampling bag (manufactured by GL Science Co.), and a 5 L sampling bag containing no sample was also prepared as a blank. After injecting 3 L of nitrogen gas containing 100 ppm of ammonia into the sampling bag, the sampling bag was immediately sealed and left standing for 1 hour under the conditions of 20° C. and 65% humidity. After standing still, 100 mL of gas in the sampling bag was sucked in with a suction device, and the concentration of ammonia was measured with a detector tube (No. 3La) manufactured by Gastec. FIG. 4 shows the change over time in the ammonia concentration when the powder obtained in Example 11 was used. For comparison, FIG. 4 also shows changes over time in the ammonia concentration when the powders obtained in Comparative Example 18 and Reference Example 1 were used.
The ammonia gas adsorption rate for the blank was calculated by the following formula.
Ammonia gas adsorption rate (%) = 100 x (blank ammonia concentration-evaluation sample ammonia concentration)/(blank ammonia concentration)
Note that the blank ammonia concentration is the ammonia concentration measured without inserting the evaluation sample, sealing the sampling bag containing only 3 L of nitrogen gas containing 100 ppm of ammonia, and allowing it to stand for 1 hour. The blank ammonia concentration was 100 ppm.
14、示差熱・熱重量測定
実施例11及び参考例1の粉末について、示差熱・熱重量測定(TG/DTA)を行った。具体的には、以下の条件により示差熱・熱重量測定(TG/DTA)を行った。測定結果を図5−1及び5−2に示す。
−測定条件−
測定機:日立ハイテクサイエンス社製、示差熱・熱重量測定装置(型番:TG/DTA6300)
昇温速度:10℃/分
測定温度範囲:30〜500℃
測定雰囲気:大気 200mL/分
リファレンス:Al2O3
サンプル重量:10.0mg
試料容器:Al14. Differential thermal/thermogravimetric measurement For the powders of Example 11 and Reference Example 1, differential thermal/thermogravimetric measurement (TG/DTA) was performed. Specifically, differential thermal/thermogravimetric measurement (TG/DTA) was performed under the following conditions. The measurement results are shown in FIGS. 5-1 and 5-2.
-Measurement conditions-
Measuring instrument: Hitachi High-Tech Science Co., Ltd., differential thermal/thermogravimetric measuring device (model number: TG/DTA6300)
Temperature rising rate: 10°C/min Measurement temperature range: 30 to 500°C
Measurement atmosphere: Atmosphere 200 mL/min Reference: Al 2 O 3
Sample weight: 10.0mg
Sample container: Al
以上の実施例及び比較例より、以下のことを確認した。
実施例1〜14で得た粉体は、全て本発明の板状ハイドロタルサイト型粒子に該当し、参考例1にある市販のハイドロタルサイト粉末に対して滑り性(MIU、MMD)が著しく高かった。特に実施例11で得た粉体は、板状硫酸バリウム・H(堺化学工業社製、MIU=0.64、MMD=0.0103)とほぼ同等又はそれ以上の滑り性を示した。このことは、例えば、実施例11で得た粉体の電子顕微鏡写真(図2−1〜2−4)からも分かるように、得られた粉体が薄板状であり、かつ表面に細かいざらつきがない平滑な粒子であることに起因するものと推測できる。一方、比較例1〜18で得た粉体は、構造式、平均板面径、アスペクト比及び顔料pHのうち1以上が本発明で規定した範囲外となる点で、いずれも本発明の板状ハイドロタルサイト型粒子とは相違するが、このような比較例1〜18で得た粉体に対して、実施例1〜14で得た粉体は、化粧料に含めた際の肌への塗布感触がきわめて良好な結果となっている(表3、4参照)。The following things were confirmed from the above Examples and Comparative Examples.
The powders obtained in Examples 1 to 14 all correspond to the plate-like hydrotalcite-type particles of the present invention, and have a remarkable slipperiness (MIU, MMD) with respect to the commercially available hydrotalcite powder in Reference Example 1. it was high. In particular, the powder obtained in Example 11 showed slipperiness almost equal to or higher than that of plate-shaped barium sulfate·H (manufactured by Sakai Chemical Industry Co., Ltd., MIU=0.64, MMD=0.0103). This is because, for example, as can be seen from the electron micrographs (FIGS. 2-1 to 2-4) of the powder obtained in Example 11, the obtained powder is in the form of a thin plate and has a finely grained surface. It can be inferred that it is due to the smooth particles having no On the other hand, the powders obtained in Comparative Examples 1 to 18 are all the plates of the present invention in that one or more of the structural formula, the average plate surface diameter, the aspect ratio and the pigment pH are out of the ranges specified in the present invention. Unlike the powder-like hydrotalcite-type particles, the powders obtained in Examples 1 to 14 are different from the powders obtained in Comparative Examples 1 to 18 to the skin when included in cosmetics. The application feeling of No. 1 is extremely good (see Tables 3 and 4).
また図3−1〜3−3及び図4より、本発明の板状ハイドロタルサイト型粒子は、アンモニアガス及びリン化合物の吸着能にも優れるものであることが分かった。例えば、実施例11で得た粉体を使用した場合、1時間後と22時間後でアンモニア濃度が変わらないため(図4参照)、1時間で吸着平衡に到達することが分かる。これに対し、比較例18で得た粉体はZn−Al型の粒状ハイドロタルサイトであり、その比表面積(SSA)は実施例11で得た粉体とほぼ同等であるものの、比較例18で得た粉体を使用した場合に比較して、実施例11で得た粉体を使用した場合はアンモニアガス吸着能が著しく高い(図4参照)。それゆえ、湿潤雰囲気で合成した本発明の板状ハイドロタルサイト型粒子(Zn−Al型)は、アンモニアガス吸着能が特異的に高いことが分かった。また、実施例11で得た粉体について、アンモニアガス吸着前後における粉体の色の変化は、目視では変化が見られなかった。更に、実施例11で得た粉体にアンモニアガスを22時間吸着させた粉を、ろ過・水洗・乾燥させ、再び同様のアンモニアガス吸着試験を行ったところ、初期と同様の吸着特性を示したことから、吸着後の再利用も可能であることが分かった。 Further, from FIGS. 3-1 to 3-3 and FIG. 4, it was found that the plate-like hydrotalcite-type particles of the present invention are excellent in the adsorption ability of ammonia gas and phosphorus compounds. For example, when the powder obtained in Example 11 is used, it can be seen that the adsorption equilibrium is reached in 1 hour because the ammonia concentration does not change after 1 hour and 22 hours (see FIG. 4). On the other hand, the powder obtained in Comparative Example 18 was Zn-Al type granular hydrotalcite, and its specific surface area (SSA) was almost the same as that of the powder obtained in Example 11, but Comparative Example 18 When the powder obtained in Example 11 is used, the ammonia gas adsorption capacity is remarkably higher than that when the powder obtained in (1) is used (see FIG. 4). Therefore, it was found that the plate-like hydrotalcite-type particles (Zn-Al type) of the present invention synthesized in a wet atmosphere have a specifically high ammonia gas adsorption capacity. Further, regarding the powder obtained in Example 11, the change in the color of the powder before and after the adsorption of ammonia gas was not visually observed. Further, the powder obtained by adsorbing ammonia gas on the powder obtained in Example 11 for 22 hours was filtered, washed with water, and dried, and the same ammonia gas adsorption test was conducted again. Therefore, it was found that it can be reused after adsorption.
したがって、本発明の板状ハイドロタルサイト型粒子は、滑り性に優れ、皮膚への刺激性が充分に低減され、かつ化粧料に含めた際の肌への塗布感触が良好なものであるうえ、アンモニアガス及びリン化合物の吸着能に際立って優れることを確認した。
Therefore, the plate-like hydrotalcite-type particles of the present invention are excellent in slipperiness, the irritation to the skin is sufficiently reduced, and the application feeling to the skin when included in a cosmetic is good. It was confirmed that the adsorption capacity for ammonia gas and phosphorus compounds was outstanding.
Claims (5)
(Zn)1−x(Al)x(OH)2(An−)x/n・mH2O (1)
(式中、An−は、n価の層間アニオンを表す。x及びnは、それぞれ、0.2≦x≦0.4、1≦n≦4の整数、の条件を満たす数である。mは、0以上の数である。)で表され、平均板面径が150〜500nm、アスペクト比(平均板面径/平均厚み)が4.0〜20.0、JIS K5101−17−1(2004年)の顔料試験方法によるpH値が6.0〜8.5である
ことを特徴とする板状ハイドロタルサイト型粒子。 Formula (1) below:
(Zn) 1-x (Al) x (OH) 2 (A n− ) x/n ·mH 2 O (1)
(In the formula, A n− represents an n-valent interlayer anion. x and n are numbers satisfying the conditions of 0.2≦x≦0.4 and 1≦n≦4, respectively. m is a number of 0 or more.), the average plate surface diameter is 150 to 500 nm, the aspect ratio (average plate surface diameter/average thickness) is 4.0 to 20.0, JIS K5101-17-. A plate-like hydrotalcite-type particle having a pH value of 6.0 to 8.5 according to the pigment test method of No. 1 (2004).
ことを特徴とする請求項1に記載の板状ハイドロタルサイト型粒子。 The plate-like hydrotalcite-type particles according to claim 1, wherein the pore volume according to the BJH method is 0.01 to 1.0 cm 3 /g.
ことを特徴とする請求項1又は2に記載の板状ハイドロタルサイト型粒子。 The plate-like hydrotalcite-type particles according to claim 1 or 2, wherein a part or all of the surface is covered with a silicon compound.
ことを特徴とする請求項1〜3のいずれかに記載の板状ハイドロタルサイト型粒子。 In the formula (1), x and n are numbers satisfying the condition of 0.30≦x≦0.35 and an integer of 1≦n≦3, respectively, and A n− is a carbonate ion (CO 3 2 − ) The plate-like hydrotalcite-type particle according to any one of claims 1 to 3, wherein
ことを特徴とする化粧料。 A cosmetic comprising the plate-shaped hydrotalcite-type particles according to any one of claims 1 to 4.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015159126 | 2015-08-11 | ||
JP2015159126 | 2015-08-11 | ||
PCT/JP2016/073042 WO2017026379A1 (en) | 2015-08-11 | 2016-08-05 | Flake-shaped hydrotalcite-type particle and application thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2017026379A1 JPWO2017026379A1 (en) | 2018-05-31 |
JP6743821B2 true JP6743821B2 (en) | 2020-08-19 |
Family
ID=57983668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017534403A Active JP6743821B2 (en) | 2015-08-11 | 2016-08-05 | Plate-shaped hydrotalcite-type particles and their use |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP6743821B2 (en) |
TW (1) | TWI703987B (en) |
WO (1) | WO2017026379A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6848540B2 (en) * | 2017-03-03 | 2021-03-24 | 堺化学工業株式会社 | Particulate inorganic compounds and their uses |
JP7239492B2 (en) * | 2017-12-25 | 2023-03-14 | 戸田工業株式会社 | Hydrotalcite particles, method for producing the same, and resin stabilizer and resin composition comprising the same |
JP7536054B2 (en) | 2022-06-30 | 2024-08-19 | セトラスホールディングス株式会社 | Fluorine adsorbent |
CN117486438B (en) * | 2024-01-03 | 2024-04-02 | 北京哈泰克工程技术有限公司 | Treatment method of desulfurization wastewater of power plant |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009120783A (en) * | 2007-11-19 | 2009-06-04 | Kaisui Kagaku Kenkyusho:Kk | Ultraviolet absorber |
JP4877539B2 (en) * | 2009-08-26 | 2012-02-15 | 戸田工業株式会社 | Hydrotalcite type particle powder, heat insulating agent for agricultural film, master batch for agricultural film and agricultural film |
JP2012246194A (en) * | 2011-05-30 | 2012-12-13 | National Institute Of Advanced Industrial Science & Technology | Lamellar double hydroxide colloidal dispersion and method for manufacturing the same |
US20160120770A1 (en) * | 2013-05-13 | 2016-05-05 | Tayca Corporation | Layered double hydroxide capable of adsorbing unsaturated fatty acids selectively, and cosmetic produced using said layered double hydroxide |
-
2016
- 2016-08-05 WO PCT/JP2016/073042 patent/WO2017026379A1/en active Application Filing
- 2016-08-05 JP JP2017534403A patent/JP6743821B2/en active Active
- 2016-08-09 TW TW105125235A patent/TWI703987B/en active
Also Published As
Publication number | Publication date |
---|---|
JPWO2017026379A1 (en) | 2018-05-31 |
TWI703987B (en) | 2020-09-11 |
TW201705935A (en) | 2017-02-16 |
WO2017026379A1 (en) | 2017-02-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11312902B2 (en) | Zinc oxide phosphor and method for producing same | |
KR101913119B1 (en) | Composite powder and method for producing same | |
EP2824073B1 (en) | Method of preparing spherical zinc oxide particles of aggregated lamellar zinc oxide | |
EP2703353B1 (en) | Zinc oxide particles, production method for same, cosmetic material, heat-dissipating filler, heat-dissipating resin composition, heat-dissipating grease, and heat-dissipating coating composition | |
JP6743821B2 (en) | Plate-shaped hydrotalcite-type particles and their use | |
CA2834233C (en) | Hexagonal prism-shaped zinc oxide particles and method for production of the same | |
EP3530261B1 (en) | Fluorescent material for cosmetics, and cosmetic | |
EP2719659B1 (en) | Manufacturing methods for rounded zinc peroxide particles and for rounded zinc oxide particles | |
EP3175836B1 (en) | Cosmetic material | |
JP5983086B2 (en) | Cosmetics | |
EP3138552A1 (en) | Cosmetic | |
WO2023106195A1 (en) | Zinc oxide particles each having surface coated with organosilicon, method for producing same, cosmetic preparation, dispersion, heat dissipating filler and resin composition | |
WO2017026380A1 (en) | Method for manufacturing flake-shaped hydrotalcite-type particle | |
JP6610379B2 (en) | Hydrotalcite-type particles and method for producing the same | |
JP6589724B2 (en) | Method for producing composite | |
JP2023084113A (en) | Hydrous silica surface coated zinc oxide particles, manufacturing method therefor, cosmetics, dispersion, heat-radiating filler, and resin composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190712 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200512 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200611 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20200630 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200713 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6743821 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |