JP6728239B2 - ３−（６−クロロ−３−オキソ−３，４−ジヒドロ−（２ｈ）−１，４−ベンゾキサジン−４−イル）プロパン酸誘導体、およびその、ｋｍｏ阻害剤としての使用 - Google Patents
３−（６−クロロ−３−オキソ−３，４−ジヒドロ−（２ｈ）−１，４−ベンゾキサジン−４−イル）プロパン酸誘導体、およびその、ｋｍｏ阻害剤としての使用 Download PDFInfo
- Publication number
- JP6728239B2 JP6728239B2 JP2017560759A JP2017560759A JP6728239B2 JP 6728239 B2 JP6728239 B2 JP 6728239B2 JP 2017560759 A JP2017560759 A JP 2017560759A JP 2017560759 A JP2017560759 A JP 2017560759A JP 6728239 B2 JP6728239 B2 JP 6728239B2
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- oxo
- dihydro
- propanoic acid
- benzoxazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- SWQBSNPMSCWTEY-UHFFFAOYSA-N CCC(c(nc1)ccc1Cl)O Chemical compound CCC(c(nc1)ccc1Cl)O SWQBSNPMSCWTEY-UHFFFAOYSA-N 0.000 description 1
- OKBIJOWBAICSRM-UHFFFAOYSA-N CCC(c(nc1)ccc1Cl)OS(C)(=O)=O Chemical compound CCC(c(nc1)ccc1Cl)OS(C)(=O)=O OKBIJOWBAICSRM-UHFFFAOYSA-N 0.000 description 1
- 0 CC[C@@](C)(*c(cc1)ncc1Cl)Oc(c(Cl)c1)cc(OC2)c1N(CCC(O)=O)C2=O Chemical compound CC[C@@](C)(*c(cc1)ncc1Cl)Oc(c(Cl)c1)cc(OC2)c1N(CCC(O)=O)C2=O 0.000 description 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1508864.4A GB201508864D0 (en) | 2015-05-22 | 2015-05-22 | Compounds |
| GB1508864.4 | 2015-05-22 | ||
| PCT/EP2016/061173 WO2016188827A1 (en) | 2015-05-22 | 2016-05-19 | 3-(6-chloro-3-oxo-3,4-dihydro-(2h)-1,4-benzoxazin-4-yl) propanoic acid derivatives and their use as kmo inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515572A JP2018515572A (ja) | 2018-06-14 |
| JP2018515572A5 JP2018515572A5 (enExample) | 2019-06-20 |
| JP6728239B2 true JP6728239B2 (ja) | 2020-07-22 |
Family
ID=53506233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560759A Active JP6728239B2 (ja) | 2015-05-22 | 2016-05-19 | ３−（６−クロロ−３−オキソ−３，４−ジヒドロ−（２ｈ）−１，４−ベンゾキサジン−４−イル）プロパン酸誘導体、およびその、ｋｍｏ阻害剤としての使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10246447B2 (enExample) |
| EP (1) | EP3298009B1 (enExample) |
| JP (1) | JP6728239B2 (enExample) |
| KR (1) | KR102648283B1 (enExample) |
| CN (1) | CN107646034B (enExample) |
| AU (1) | AU2016266548B2 (enExample) |
| CA (1) | CA2986609C (enExample) |
| ES (1) | ES2776462T3 (enExample) |
| GB (1) | GB201508864D0 (enExample) |
| RU (1) | RU2746001C2 (enExample) |
| WO (1) | WO2016188827A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100486099B1 (ko) * | 2002-07-12 | 2005-04-29 | 진금수 | 히트 펌프 시스템 |
| KR100486096B1 (ko) * | 2002-07-12 | 2005-04-29 | 진금수 | 히트 펌프 시스템 |
| GB2568549A (en) * | 2017-11-21 | 2019-05-22 | Univ Leicester | New compounds and uses |
| TW202028468A (zh) | 2018-10-15 | 2020-08-01 | 美商航海家醫療公司 | 用於桿狀病毒/Sf9系統中rAAV之大規模生產的表現載體 |
| WO2024054983A1 (en) | 2022-09-08 | 2024-03-14 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9522615D0 (en) * | 1995-11-03 | 1996-01-03 | Pharmacia Spa | 4-Phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity |
| JPH11180966A (ja) * | 1997-09-09 | 1999-07-06 | Sankyo Co Ltd | アゾール誘導体 |
| SE9904652D0 (sv) * | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
| US6750215B2 (en) * | 2001-08-08 | 2004-06-15 | Pharmacia & Upjohn, S.P.A. | Substituted benzoxazines as integrin antagonists |
| EP1424333A1 (en) | 2002-11-28 | 2004-06-02 | Newron Pharmaceuticals S.p.A. | Halothenoyl-cyclopropane-1-carboxylic acid derivatives |
| EP1475385A1 (en) | 2003-05-05 | 2004-11-10 | Newron Pharmaceuticals S.p.A. | Glycoside derivatives of 2-(3,4-dichlorobenzoyl)-cycopropane-1-carboxylic acid |
| FR2881138B1 (fr) * | 2005-01-27 | 2007-03-02 | Servier Lab | Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2007086504A1 (ja) * | 2006-01-27 | 2007-08-02 | Japan Tobacco Inc. | カルボン酸化合物及びその用途 |
| US7994338B2 (en) | 2006-08-16 | 2011-08-09 | The J. David Gladstone Institutes | Small molecule inhibitors of kynurenine-3-monooxygenase |
| DK2420494T3 (en) | 2006-08-16 | 2015-01-12 | J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone | Use of thiadiazole compounds as inhibitors of kynurenine 3-monooxygenase |
| WO2010011302A1 (en) | 2008-07-22 | 2010-01-28 | Chdi, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| RU2523448C2 (ru) | 2008-08-04 | 2014-07-20 | СиЭйчДиАй ФАУНДЕЙШН, Инк, | Ингибиторы кинуренин-3-монооксигеназы |
| US8691824B2 (en) | 2008-08-04 | 2014-04-08 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| DK2400968T3 (da) * | 2009-02-26 | 2017-01-02 | Reviva Pharmaceuticals Inc | Sammensætninger, syntese og fremgangsmåder til anvendelse af arylpiperazinderivater |
| JP2013518046A (ja) | 2010-01-25 | 2013-05-20 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | 特定のキヌレニン−３−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法 |
| JP2013030505A (ja) | 2011-07-26 | 2013-02-07 | Sumitomo Electric Ind Ltd | Ｉｉｉ族窒化物半導体レーザ素子 |
| JP2014521651A (ja) | 2011-07-28 | 2014-08-28 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | 特定のキヌレニン−３−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法 |
| MX2014002459A (es) * | 2011-08-30 | 2014-04-10 | Chdi Foundation Inc | Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodos de uso de los mismos. |
| SG11201406311UA (en) * | 2012-04-05 | 2014-11-27 | Chdi Foundation Inc | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| GB201322512D0 (en) * | 2013-12-19 | 2014-02-05 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
-
2015
- 2015-05-22 GB GBGB1508864.4A patent/GB201508864D0/en not_active Ceased
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2016
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- 2016-05-19 WO PCT/EP2016/061173 patent/WO2016188827A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2986609C (en) | 2024-01-09 |
| EP3298009A1 (en) | 2018-03-28 |
| WO2016188827A1 (en) | 2016-12-01 |
| US10246447B2 (en) | 2019-04-02 |
| CN107646034B (zh) | 2021-06-15 |
| KR20180005189A (ko) | 2018-01-15 |
| US20180170920A1 (en) | 2018-06-21 |
| RU2746001C2 (ru) | 2021-04-05 |
| AU2016266548A1 (en) | 2017-11-16 |
| US20190169178A1 (en) | 2019-06-06 |
| KR102648283B1 (ko) | 2024-03-14 |
| CA2986609A1 (en) | 2016-12-01 |
| CN107646034A (zh) | 2018-01-30 |
| ES2776462T3 (es) | 2020-07-30 |
| BR112017025052A2 (pt) | 2018-08-07 |
| RU2017145086A (ru) | 2019-06-25 |
| GB201508864D0 (en) | 2015-07-01 |
| EP3298009B1 (en) | 2019-12-18 |
| JP2018515572A (ja) | 2018-06-14 |
| RU2017145086A3 (enExample) | 2019-09-26 |
| AU2016266548B2 (en) | 2019-04-18 |
| US10611756B2 (en) | 2020-04-07 |
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