JP6688514B2 - 光学測定用フローセル - Google Patents
光学測定用フローセル Download PDFInfo
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- JP6688514B2 JP6688514B2 JP2018559102A JP2018559102A JP6688514B2 JP 6688514 B2 JP6688514 B2 JP 6688514B2 JP 2018559102 A JP2018559102 A JP 2018559102A JP 2018559102 A JP2018559102 A JP 2018559102A JP 6688514 B2 JP6688514 B2 JP 6688514B2
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- flow
- flow path
- optical measurement
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- flow cell
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- 230000003287 optical effect Effects 0.000 title claims description 54
- 238000005259 measurement Methods 0.000 title claims description 41
- 239000007788 liquid Substances 0.000 claims description 35
- 239000002245 particle Substances 0.000 claims description 21
- 230000031700 light absorption Effects 0.000 claims description 7
- 239000012780 transparent material Substances 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 description 5
- 238000004088 simulation Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000003973 paint Substances 0.000 description 3
- 239000010453 quartz Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 238000011109 contamination Methods 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000005653 Brownian motion process Effects 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 238000005537 brownian motion Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000009751 slip forming Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
- G01N2021/054—Bubble trap; Debubbling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
- G01N2021/513—Cuvettes for scattering measurements
Landscapes
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Description
5 光源
5a、5b 光学ブロック
8 カメラ
10 流路
12a、12b 延長流路
13a、13b 外側開口端部
20 流路ブロック
21 液体媒質流入ブロック
22 液体媒質流出ブロック
25 緩衝材
31、32 サイドブロック
35a 流入配管
35b 流出配管
36a、36b 固定パーツ
41a、41b 窓押しブロック
Claims (10)
- 流路内の流れ方向と略平行にレーザ光を与えて該流路内を流れる液体媒質中の粒子を光学的に計測するための光学測定用フローセルであって、
一対の液体媒質流入ブロック及び流出ブロックの間に略直方体の透明材料からなる流路ブロックを着脱自在に挟み込んで、前記流路ブロックの両端面のそれぞれに前記液体媒質流入ブロック及び流出ブロックの光吸収面を押圧し、
前記流路ブロックの前記両端面間を貫通する中央軸線に沿って前記流路を設け、
前記流入ブロック及び流出ブロックを貫通し前記中央軸線に沿って延長流路を設け、この外側開口端部には光学窓を着脱自在に与えてこれを封止するとともに、前記外側開口端部近傍で前記中央軸線と交差する導入軸線に沿って前記液体媒質の出入路を設けられることを特徴とする光学測定用フローセル。 - 前記中央軸線に対して角度を有する方向から前記レーザ光の散乱光を検出することを特徴とする請求項1記載の光学測定用フローセル。
- 前記流路はストレート管であって且つ断面を四角形とすることを特徴とする請求項1記載の光学測定用フローセル。
- 前記延長流路は前記流路における流速を減じるよう、前記流路の断面よりも大なる断面積を有することを特徴とする請求項3記載の光学測定用フローセル。
- 前記延長流路は断面を円形とすることを特徴とする請求項4記載の光学測定用フローセル。
- 前記導入軸線は前記中央軸線に対して垂直から傾斜し前記流路ブロックへ向けて流れ成分を与えるようにされていることを特徴とする請求項5記載の光学測定用フローセル。
- 前記流路の中心部を拡張した拡張部を与えられていることを特徴とする請求項1記載の光学測定用フローセル。
- 前記拡張部は前記中央軸線に垂直に軸線を与えられた六角柱状であることを特徴とする請求項7記載の光学測定用フローセル。
- 前記拡張部は前記軸線の方向成分を有さず前記中央軸線に平行な成分のみからなる流速ベクトルを形成することを特徴とする請求項8記載の光学測定用フローセル。
- 前記中央軸線に対して略垂直方向から前記レーザ光の散乱光を検出することを特徴とする請求項9記載の光学測定用フローセル。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016253627 | 2016-12-27 | ||
JP2016253627 | 2016-12-27 | ||
PCT/JP2017/045750 WO2018123771A1 (ja) | 2016-12-27 | 2017-12-20 | 光学測定用フローセル |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2018123771A1 JPWO2018123771A1 (ja) | 2019-10-31 |
JP6688514B2 true JP6688514B2 (ja) | 2020-04-28 |
Family
ID=62707518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018559102A Active JP6688514B2 (ja) | 2016-12-27 | 2017-12-20 | 光学測定用フローセル |
Country Status (4)
Country | Link |
---|---|
US (1) | US20190383726A1 (ja) |
JP (1) | JP6688514B2 (ja) |
GB (1) | GB2573890B (ja) |
WO (1) | WO2018123771A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20200034563A (ko) * | 2018-09-20 | 2020-03-31 | 주식회사 제우스 | 유동매체 모니터링장치 |
JP7260308B2 (ja) * | 2019-01-24 | 2023-04-18 | リオン株式会社 | 流体中浮遊物質測定用フローセル及び粒子計数装置 |
US11733144B2 (en) * | 2020-12-14 | 2023-08-22 | Caterpillar Inc. | Convertible housing assembly for a particle sensor |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4913355Y1 (ja) * | 1967-10-27 | 1974-04-02 | ||
JPS53129983U (ja) * | 1977-03-23 | 1978-10-16 | ||
JPS63158456A (ja) * | 1986-12-22 | 1988-07-01 | Shimadzu Corp | 液体クロマトグラフイ用濃度モニタリングブロツク |
US4886356A (en) * | 1988-04-01 | 1989-12-12 | The Perkin-Elmer Corporation | Detector cell for liquid chromatography |
US5407638A (en) * | 1993-04-28 | 1995-04-18 | Shell Oil Company | Detector-cell adapted for continuous-flow absorption detection |
US5404217A (en) * | 1993-08-26 | 1995-04-04 | Janik; Gary R. | Laser liquid flow cell manifold system and method for assembly |
JP3762677B2 (ja) * | 2001-01-29 | 2006-04-05 | 株式会社 堀場アドバンスドテクノ | 流体分析用セルおよびこれを用いた分析装置 |
GB0703250D0 (en) * | 2007-02-20 | 2007-03-28 | Ge Healthcare Bio Sciences Ab | Ultrasonic flow meter |
JP2008224342A (ja) * | 2007-03-12 | 2008-09-25 | Rion Co Ltd | フローセル、フローセルの製造方法及び粒子測定装置 |
US9719917B2 (en) * | 2008-11-24 | 2017-08-01 | Ge Healthcare Bio-Sciences Ab | Flow cell optical detection system |
US7982875B2 (en) * | 2009-06-15 | 2011-07-19 | Wyatt Technology Corporation | Method and apparatus for measuring the scattered light signals from a liquid sample |
JP5047248B2 (ja) * | 2009-09-30 | 2012-10-10 | 株式会社日立ハイテクノロジーズ | フローセル,検出器、および液体クロマトグラフ |
KR101275742B1 (ko) * | 2011-06-23 | 2013-06-17 | 주식회사 아이센스 | 광학 분석용 셀 |
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2017
- 2017-12-20 WO PCT/JP2017/045750 patent/WO2018123771A1/ja active Application Filing
- 2017-12-20 GB GB1908688.3A patent/GB2573890B/en active Active
- 2017-12-20 JP JP2018559102A patent/JP6688514B2/ja active Active
- 2017-12-20 US US16/471,669 patent/US20190383726A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
GB2573890B (en) | 2022-06-01 |
JPWO2018123771A1 (ja) | 2019-10-31 |
US20190383726A1 (en) | 2019-12-19 |
WO2018123771A1 (ja) | 2018-07-05 |
GB201908688D0 (en) | 2019-07-31 |
GB2573890A (en) | 2019-11-20 |
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