JP6669868B2 - フタラジン誘導体、その製造方法、医薬組成物および使用 - Google Patents
フタラジン誘導体、その製造方法、医薬組成物および使用 Download PDFInfo
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- JP6669868B2 JP6669868B2 JP2018530763A JP2018530763A JP6669868B2 JP 6669868 B2 JP6669868 B2 JP 6669868B2 JP 2018530763 A JP2018530763 A JP 2018530763A JP 2018530763 A JP2018530763 A JP 2018530763A JP 6669868 B2 JP6669868 B2 JP 6669868B2
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- 125000003554 tetrahydropyrrolyl group Chemical group 0.000 description 1
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 206010048627 thoracic outlet syndrome Diseases 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 230000006411 tonic activation Effects 0.000 description 1
- 230000009478 tonic inhibition Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- JLTRXTDYQLMHGR-UHFFFAOYSA-N trimethylaluminium Chemical compound C[Al](C)C JLTRXTDYQLMHGR-UHFFFAOYSA-N 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical class CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
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- 210000001364 upper extremity Anatomy 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 208000027185 varicose disease Diseases 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510900083.4 | 2015-12-08 | ||
| CN201510900083.4A CN106854207B (zh) | 2015-12-08 | 2015-12-08 | 呔嗪类衍生物、其制备方法、药物组合物和用途 |
| PCT/CN2016/108975 WO2017097217A1 (zh) | 2015-12-08 | 2016-12-08 | 呔嗪类衍生物、其制备方法、药物组合物和用途 |
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| JP2018537480A JP2018537480A (ja) | 2018-12-20 |
| JP2018537480A5 JP2018537480A5 (enExample) | 2019-02-28 |
| JP6669868B2 true JP6669868B2 (ja) | 2020-03-18 |
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| EP (1) | EP3388433B1 (enExample) |
| JP (1) | JP6669868B2 (enExample) |
| CN (1) | CN106854207B (enExample) |
| WO (1) | WO2017097217A1 (enExample) |
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| EP3766882B1 (en) * | 2018-03-12 | 2023-08-23 | Shanghai Simr Biotechnology Co., Ltd. | Phthalazine isoxazole alkoxy derivatives, preparation method thereof, pharmaceutical composition and use thereof |
| CN112979655A (zh) | 2019-12-16 | 2021-06-18 | 上海赛默罗生物科技有限公司 | 三唑并哒嗪类衍生物、其制备方法、药物组合物和用途 |
| US20240059691A1 (en) * | 2020-12-01 | 2024-02-22 | Kalvista Pharmaceuticals Limited | Enzyme inhibitors |
| CN112441901B (zh) * | 2020-12-15 | 2023-08-29 | 山东泰和科技股份有限公司 | 一种乙酸酐的合成方法 |
| CN116008443B (zh) * | 2023-03-28 | 2023-06-30 | 上海赛默罗生物科技有限公司 | α5-GABAA受体调节剂类药物中有关物质的检测方法 |
| CN119019425A (zh) * | 2023-05-26 | 2024-11-26 | 武汉人福创新药物研发中心有限公司 | 一种作为α5-GABAA受体调节剂的杂环化合物 |
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| GB9112504D0 (en) | 1991-06-11 | 1991-07-31 | Merck Sharp & Dohme | Cell line |
| DE69320985T2 (de) | 1992-12-10 | 1999-05-12 | Merck Sharp & Dohme | Stabil transfizierte zelllinien welche gaba-a rezeptoren exprimieren |
| AU732455C (en) | 1997-05-08 | 2002-09-05 | Merck Sharp & Dohme Limited | Substituted 1,2,4-triazolo{3,4-a}phthalazine derivatives as gaba alpha 5 ligands |
| GB9715977D0 (en) | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
| US6297235B1 (en) * | 1997-08-28 | 2001-10-02 | Merck Sharp & Dohme Ltd. | Triazolopyridazine derivatives for treating anxiety and enhancing cognition |
| IL149550A0 (en) * | 1999-11-12 | 2002-11-10 | Neurogen Corp | Bicyclic and tricyclic heteroaromatic compounds |
| GB0028583D0 (en) * | 2000-11-23 | 2001-01-10 | Merck Sharp & Dohme | Therapeutic compounds |
| US20050043982A1 (en) * | 2003-08-22 | 2005-02-24 | Nguyen Vinh Dinh | Contextual workflow modeling |
| JP2007509150A (ja) * | 2003-10-21 | 2007-04-12 | メルク エンド カムパニー インコーポレーテッド | 神経障害性疼痛の治療において有用なトリアゾロ−ピリダジン化合物および、この誘導体 |
| US10206921B2 (en) | 2009-06-03 | 2019-02-19 | The Regents Of The University Of California | Methods and compositions for treating a subject for central nervous system (CNS) injury |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
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2015
- 2015-12-08 CN CN201510900083.4A patent/CN106854207B/zh active Active
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2016
- 2016-12-08 WO PCT/CN2016/108975 patent/WO2017097217A1/zh not_active Ceased
- 2016-12-08 EP EP16872406.0A patent/EP3388433B1/en active Active
- 2016-12-08 US US16/060,256 patent/US11220503B2/en active Active
- 2016-12-08 JP JP2018530763A patent/JP6669868B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US11220503B2 (en) | 2022-01-11 |
| CN106854207A (zh) | 2017-06-16 |
| WO2017097217A1 (zh) | 2017-06-15 |
| CN106854207B (zh) | 2019-10-29 |
| US20200165253A1 (en) | 2020-05-28 |
| JP2018537480A (ja) | 2018-12-20 |
| EP3388433B1 (en) | 2023-08-30 |
| EP3388433A1 (en) | 2018-10-17 |
| EP3388433A4 (en) | 2019-08-07 |
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