JP6661948B2 - Urine component analyzer and urine component analysis method - Google Patents

Description

  The present invention relates to a urine component analyzer and a urine component analysis method, and more particularly to a urine component analyzer and a urine component analysis method for determining a concentration ratio between sodium and potassium in urine excreted by a subject.

As a technique for analyzing a urine component, for example, as disclosed in Patent Document 1 (WO 2013/021695 A1),
"The concentration ratio between the first specific component and the second specific component in one urine excreted by a human, and the total of the one day when the urine excreted by the human in one day is collected into one Data indicating a correlation between the first specific component and the concentration ratio between the second specific component in urine is stored in a predetermined storage unit,
Data representing the concentration ratio between the first specific component and the second specific component in one urine excreted by the subject is input,
Using the correlation stored in the storage unit, based on the input concentration ratio between the first specific component and the second specific component in the urine of the subject at one time, the measurement is performed. It is determined by converting the concentration ratio between the first specific component and the second specific component in the whole urine of the day when the person collects all urine excreted in one day. "
The technique is known.

  According to the document, as the correlation, "an average concentration obtained by averaging the concentration ratio between the first specific component and the second specific component in urine excreted over one or more days by the human being" And the concentration ratio between the first specific component and the second specific component in the whole urine for one or more days when the human collects all urine excreted over one or more days. And the average of the concentration ratios between the first specific component and the second specific component in the plurality of urines excreted by the subject over one or more days. A density ratio is obtained, and the average density ratio is subjected to the above conversion. "

WO 2013/021695 A1

Hypertension Research, August 2014, Vol. 37 (8), p. 765-771

  Here, the present inventors repeatedly measured the concentration ratio between sodium and potassium as two specific components in urine (appropriately referred to as “Na / K ratio”). Shows a tendency to increase or decrease depending on the time of day in the day (this is referred to as “intra-day fluctuation”), and the intra-day fluctuation is repeated every day in a substantially constant pattern. It turned out (it shows in detail by showing actual data later). Therefore, if the influence of circadian variation can be reduced on the data of the Na / K ratio in the urine excreted by the subject, that is, the conversion target by the arithmetic unit, the Na / K ratio obtained by the conversion Accuracy may be improved.

  Accordingly, an object of the present invention is to provide a urine component analyzer and a urine component analysis method capable of accurately determining the concentration ratio between sodium and potassium in urine excreted by a subject.

In order to solve the above problems, a urine component analyzer of the present invention includes:
The concentration ratio between sodium and potassium in one urine excreted by a human, and the sodium-potassium concentration in the whole urine of the day when all the urine excreted by the human is collected in one day A correlation storage unit storing data representing a correlation between the concentration ratio of
The candidate correction amount for correcting the concentration ratio is distinguished according to the time period during which one urine is excreted so as to reduce the influence of the circadian variation indicated by the concentration ratio in one urine. A stored candidate correction amount storage unit;
A data input unit for inputting data representing the concentration ratio between sodium and potassium in one urine excreted by the subject;
With reference to the candidate correction amount storage unit, the 1st of the subject obtained via the data input unit using the candidate correction amount according to the time period during which one urine was excreted. A data correction unit for correcting the concentration ratio between sodium and potassium in urine of the times,
Using the correlation stored in the correlation storage unit based on the concentration ratio between sodium and potassium in the urine of the subject once corrected by the data correction unit, A calculating unit for converting the concentration ratio between sodium and potassium in the whole urine of the day when the measurer collects all urine excreted in one day. It is characterized by.

  In this specification, "human" may be the same person as "subject". The “human” may be a plurality of persons, and in that case, may include the “subject”. The “human” may be a person other than the “subject”.

  “Daily fluctuation” means a tendency that the concentration ratio between sodium and potassium in one urine of a human increases or decreases depending on the time of day. The present inventors have repeatedly measured and found that the daily fluctuation is repeated every day in a substantially constant pattern.

  Correcting “to reduce the effect” of the daily fluctuation means, for example, that the concentration ratio between sodium and potassium in one urine is represented by a representative value (eg, average value, median value, etc.) in one day. It means that correction is made to approach.

  The “time zone” refers to a time zone when a day is divided into a plurality (for example, 3, 4, 6, 8, 12, 24, etc.). For example, when a day is divided into three, a time zone from 0:00 to 8:00 (this is called a “morning time zone”) and a time zone from 8:00 to 16:00 (this is called “daytime zone”). ) And a time zone from 16:00 to 24:00 (this is called a “night time zone”). It is assumed that the time at the boundary between “time zones” belongs to one of the earlier or later time zones forming the boundary.

In the urine component analyzer of the present invention, the correlation storage unit collects the concentration ratio between sodium and potassium in one urine excreted by a human and all the urine excreted by the human in one day. The data representing the correlation between the concentration of sodium and potassium in the whole urine on the day described above is stored. The candidate correction amount storage unit stores the candidate correction amount for correcting the concentration ratio so as to reduce the influence of the circadian fluctuation indicated by the concentration ratio in one urine, and stores the candidate correction amount for the one urine concentration. And stored according to the time zone. The data input unit inputs data representing the concentration ratio between sodium and potassium in one urine excreted by the subject. The data correction unit refers to the candidate correction amount storage unit and uses the candidate correction amount according to the time period during which one urine is excreted, and obtains the target correction amount obtained through the data input unit. the sodium in the one urine of the measurer, to correct the concentration ratio between potassium. The calculation unit uses the correlation stored in the correlation storage unit based on the concentration ratio between sodium and potassium in the urine of the subject once corrected by the data correction unit. Then, the concentration ratio between the sodium and potassium in the whole urine of the day is calculated by assuming that all urine excreted by the subject in a day is collected into one.

Here, the urine component analyzer converts the concentration ratio between sodium and potassium in whole urine in one day based on the concentration ratio between sodium and potassium in one urine excreted by the subject. It is not necessary to actually measure the amount of urine excreted by the subject. If the concentration ratio between sodium and potassium in at least one urine excreted by the subject is obtained as input data, a conversion result is obtained. Therefore, according to this urine component analyzer, the concentration ratio between sodium and potassium in the whole day urine excreted by the subject can be easily obtained. In addition, in this urine component analyzer, the data correction unit refers to the candidate correction amount storage unit and uses the candidate correction amount according to the time period during which one urine was excreted to perform the data input. the sodium in the one urine of the measured person obtained through the section, to correct the concentration ratio between potassium. As a result, it is possible to reduce the influence of the daily fluctuation on the conversion target by the arithmetic unit. Therefore, the concentration ratio between sodium and potassium in the whole day urine excreted by the subject can be accurately obtained. In addition, urine in various time zones can be used as a measurement target. Therefore, the subject can be released from the restriction that urine must be collected at a predetermined time.

  Note that the data input unit may temporarily input data representing the respective concentrations of sodium and potassium in one urine excreted by the subject, and take the concentration ratio between the sodium and potassium before the correction. good.

In one embodiment of the urine component analyzer,
The correlation storage unit stores a statistical concentration ratio obtained by performing statistical processing on the concentration ratio between sodium and potassium in urine excreted over one or more days by the human, and Storing data representing a correlation between the concentration ratio of sodium and potassium in the whole urine for one or more days when all urine excreted over one or more days is collected into one. Yes,
The data input unit inputs data representing a concentration ratio between the sodium and potassium in the urine of one time excreted by the subject,
The data correction unit corrects the concentration ratio between sodium and potassium in the urine of the subject once obtained through the data input unit, for each data representing the concentration ratio ,
The arithmetic unit performs a statistical process on the concentration ratio between sodium and potassium in urine in a plurality of times corrected by the data correction unit to obtain a statistical concentration ratio, and the statistical concentration ratio is subjected to the conversion. It is characterized by the following.

  “Statistical processing” refers to processing for obtaining an average value, a median value, or other statistical values. The “statistical concentration ratio” means an average concentration ratio (average concentration ratio) or a central concentration ratio (median concentration ratio) obtained by the statistical processing.

In the urine component analyzer of this embodiment, the correlation storage unit performs statistical processing on a concentration ratio between sodium and potassium in urine excreted multiple times by the human over one or more days. The obtained statistical concentration ratio and the concentration ratio between sodium and potassium in the whole urine for one or more days when the human collects all urine excreted over one or more days. Data representing the correlation between the two is stored. The data input unit inputs data representing the concentration ratio between sodium and potassium in the urine excreted once by the subject. The data correction unit corrects the concentration ratio between sodium and potassium in the urine of the subject once obtained via the data input unit, for each data representing the concentration ratio . The arithmetic unit performs a statistical process on the concentration ratio between sodium and potassium in urine in a plurality of times corrected by the data correction unit to obtain a statistical concentration ratio, and the statistical concentration ratio is subjected to the conversion. To That is, based on the obtained statistical concentration ratio between sodium and potassium, the arithmetic unit uses the correlation stored in the correlation storage unit to calculate the subject for one or more days. The concentration ratio between sodium and potassium in the whole urine for one or more days is calculated by assuming that all excreted urine is collected as one. In this case, the accuracy of the calculated concentration ratio between sodium and potassium in the whole urine for one or more days is improved.

In the urine component analyzer of one embodiment, the candidate correction amount is a correction amount that brings the concentration ratio in one urine closer to a representative value of circadian variation indicated by the concentration ratio in one urine. It is characterized by.

In the urine component analyzer of this embodiment, the accuracy of the calculated concentration ratio between sodium and potassium is further improved.

In one embodiment of the urine component analyzer,
The candidate correction amount storage unit stores the candidate correction amount separately according to the attribute of the human,
An attribute input unit for inputting the attribute of the subject;
The data correction unit refers to the candidate correction amount storage unit, selects a candidate correction amount according to the attribute of the subject, and uses the candidate correction amount for the correction.

  The "attribute" of a human (and the subject) is the ethnicity to which the human belongs, the area where the human resides, whether the human has a lifestyle-related disease such as hypertension or diabetes, or the human Includes what medications are taken or not.

  In the urine component analyzer according to this embodiment, the candidate correction amount storage unit stores the candidate correction amounts separately according to the attributes of the human. The attribute input unit inputs the attribute of the subject. The data correction unit refers to the candidate correction amount storage unit, selects a candidate correction amount according to the attribute of the subject, and uses the candidate correction amount for the correction. Therefore, by the correction by the data correction unit, the diurnal variation indicated by the concentration ratio between sodium and potassium in the urine of the subject at one time is appropriately corrected according to the attribute of the subject. it can. As a result, it is possible to further reduce the influence of daily fluctuation on the conversion target by the arithmetic unit. Accordingly, the concentration ratio between sodium and potassium in the whole urine of the subject excreted in one day can be obtained with higher accuracy.

In one embodiment of the urine component analyzer,
The correlation storage unit stores the correlation separately according to the time zone,
The calculation unit refers to the correlation storage unit and uses a correlation corresponding to a time period during which one urine is excreted for the conversion.

  In the urine component analyzer according to this embodiment, the correlation storage unit stores the correlation in a distinctive manner according to the time zone. The calculation unit refers to the correlation storage unit and uses the correlation corresponding to the time period during which one urine is excreted for the conversion. In this case, the accuracy of the calculated concentration ratio between sodium and potassium in the whole urine for one or more days is further improved.

In one embodiment of the urine component analyzer,
The correlation storage unit stores the correlation separately according to the attribute of the human,
An attribute input unit for inputting the attribute of the subject;
The arithmetic unit refers to the correlation storage unit and uses a correlation corresponding to the attribute of the subject for the conversion.

  In the urine component analyzer according to this embodiment, the correlation storage unit stores the correlation in a distinguishable manner according to the attribute of the human. The attribute input unit inputs the attribute of the subject. The calculation unit refers to the correlation storage unit and uses the correlation according to the attribute of the subject for the conversion. In this case, the accuracy of the calculated concentration ratio between sodium and potassium in the whole urine for one or more days is further improved.

The urine component analysis method of the present invention comprises:
The concentration ratio between sodium and potassium in one urine excreted by a human, and the sodium-potassium concentration in the whole urine of the day when all the urine excreted by the human is collected in one day The data representing the correlation between the concentration ratio of the is stored in a predetermined correlation storage unit,
The candidate correction amount for correcting the concentration ratio is distinguished according to the time period during which one urine is excreted so as to reduce the influence of the circadian variation indicated by the concentration ratio in one urine. Stored in the candidate correction amount storage unit,
The data representing the concentration ratio between sodium and potassium in one urine excreted by the subject is input,
With reference to the candidate correction amount storage unit, the sodium in the one-time urine of the subject is input using the candidate correction amount according to the time period during which the one urine is excreted. to correct the concentration ratio between potassium,
Based on the corrected concentration ratio between the sodium and potassium in the urine of the subject at one time, the subject is set to 1 using the correlation stored in the correlation storage unit. It is characterized in that the concentration ratio between the sodium and potassium in the whole urine of the day is calculated by converting all the urine excreted on the day into one.

In the urine component analysis method of the present invention, the concentration ratio between sodium and potassium in the whole urine of the day is converted based on the concentration ratio between sodium and potassium in one urine excreted by the subject. It is not necessary to actually measure the amount of urine excreted by the subject. If the concentration ratio between sodium and potassium in at least one urine excreted by the subject is obtained as input data, a conversion result is obtained. Therefore, according to this urine component analysis method, it is possible to easily obtain the concentration ratio between sodium and potassium in the whole urine of the subject excreted in one day. Moreover, in this urine component analysis method , the input of the subject is input using the candidate correction amount corresponding to the time period during which one urine was excreted with reference to the candidate correction amount storage unit . The concentration ratio between sodium and potassium in one urine is corrected. As a result, the influence of daily fluctuation can be reduced for the above conversion target. Therefore, the concentration ratio between sodium and potassium in the whole day urine excreted by the subject can be accurately obtained. In addition, urine in various time zones can be used as a measurement target. Therefore, the subject can be released from the restriction that urine must be collected at a predetermined time.

  As is clear from the above, according to the urine component analyzer and the urine component analysis method of the present invention, the concentration ratio between sodium and potassium in urine excreted by the subject can be obtained with high accuracy.

It is a figure showing the block composition of the urine constituent analyzer of one embodiment of the present invention. 2 (A), (B), and (C) are diagrams each showing a mode in which the urine component analyzer is used. FIG. 2D is a diagram illustrating a preferred embodiment of a handheld urine component analyzer. It is a figure showing an example of a flow of a calculation which a control part of the above-mentioned urine constituent analyzing device performs. It is a figure which shows another example of the flow of the calculation which the control part of the said urine component analyzer performs. It is a figure which shows an example of the operation | movement flow of the said urine component analyzer. FIG. 6 (A) shows the actual measured Na / K ratio of one urine or the average Na / K ratio obtained using a plurality of urines when using urine in the morning time zone. FIG. 7 is a diagram showing a correlation between the total urine Na / K ratio for one or more days. FIG. 6 (B) shows the actual measured Na / K ratio of one urine or the average Na / K ratio obtained using a plurality of urines when urine in the daytime is used. FIG. 7 is a diagram showing a correlation between the total urine Na / K ratio for one or more days. FIG. 7A shows the measured Na / K ratio of one measured urine or the average Na / K ratio obtained using a plurality of times of urine when urine in the night time zone is used. FIG. 7 is a diagram showing a correlation between the total urine Na / K ratio for one or more days. FIG. 7 (B) shows the average Na / K ratio obtained using urine measured a plurality of times, and the actually measured one or more days when urine was used in all times of the morning, day and night. It is a figure which shows the correlation between Na / K ratio in whole urine. FIGS. 8A and 8B are diagrams showing the correlation when the number of urines is specified in addition to the attributes and the time zones of the human. FIGS. 9 (A) and 9 (B) show the case where the attribute of the subject is general, and data of one urine in the morning time zone is used as the measurement target, and the total urine in one day obtained by conversion is obtained. FIG. 7 is a diagram showing the accuracy of the Na / K ratio in FIG. 7 in comparison with the presence or absence of correction according to the time zone. FIGS. 10A and 10B show Bland-Altman plots (Bland-Altman plot) showing the accuracy of the Na / K ratio in whole-day urine obtained by the same conversion as in FIGS. 9A and 9B. -Altman plot) for comparison with the presence or absence of correction according to the time zone. FIGS. 11 (A) and 11 (B) show one or more days obtained by conversion when the subject's attributes are general and seven urine data in the morning time zone are used as the measurement target. It is a figure which compares and shows the accuracy of Na / K ratio in whole urine by the presence or absence of the correction according to a time zone. 12 (A) and (B) show the accuracy of the Na / K ratio in whole urine for one or more days obtained by the same conversion as in FIGS. 11 (A) and (B). It is a figure which shows by comparison with the presence or absence of the correction | amendment according to the time zone by plotting. It is the figure which represented the diurnal variation which Na / K ratio shows in one urine of a human in a graph. It is a figure which shows the correction | amendment amount which should correct Na / K ratio in one urine when the said human is Asian according to the time zone in which one urine was excreted. It is a figure which shows the correction | amendment amount which should correct Na / K ratio in one urine when the said human is a black person according to the time zone in which one urine was excreted. It is a figure which shows the correction amount which should correct the Na / K ratio in one urine when the said human is a Caucasian according to the time zone in which one urine was excreted. FIGS. 17 (A) and 17 (B) show that when the attribute of the subject is black and the data of one time urine is used as a measurement target, Na in the total urine of one day obtained by conversion is shown. It is a figure which shows and compares the precision of / K ratio by the presence or absence of the correction according to a time zone. FIGS. 18 (A) and (B) show the accuracy of the Na / K ratio in whole-day urine obtained by the same conversion as in FIGS. 17 (A) and (B), using a Brand-Altman plot. FIG. 9 is a diagram showing a comparison based on the presence or absence of a correction according to a time zone. FIGS. 19 (A) and 19 (B) show that when the attribute of the subject is Caucasian and data of one time urine is used as a measurement object, Na in the total urine of one day obtained by conversion is shown. It is a figure which shows and compares the precision of / K ratio by the presence or absence of the correction according to a time zone. FIGS. 20 (A) and (B) show the accuracy of the Na / K ratio in whole-day urine obtained by the same conversion as in FIGS. 19 (A) and (B), using a Brand-Altman plot. FIG. 9 is a diagram showing a comparison based on the presence or absence of a correction according to a time zone. It is a figure showing an example of the contents of an advice table.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

  FIG. 1 shows a block configuration of a urine component analyzer (entirely indicated by reference numeral 90) according to an embodiment of the present invention.

  The urine component analyzer 90 includes a housing 10, a control unit 11, a data input unit 12, an operation unit 13, a storage unit 14, a display unit 18, a clock 41, and an alarm unit which are mounted and housed in the housing 10. 44, and a network communication unit 42. Further, the urine component analyzer 90 includes a sensor unit 30 attached to the housing 10 so as to protrude from the housing 10 to the outside.

  In this example, as shown in FIG. 2A, the housing 10 has an elongated prismatic outer shape to be held by the user's hand. The sensor unit 30 has an elongated rod-like outer shape attached to one end of the housing 10. As a result, the urine component analyzer 90 is configured as a hand-held type urine component analyzer used by a user holding the housing 10 in his hand.

  The sensor unit 30 is a well-known sensor, and comes into contact with urine 99 excreted by the subject, and the concentration ratio between two specific components (sodium and potassium in this example) in urine (this is referred to as “Na”). / K ratio ”).

  For example, when using the urine component analyzer 90 of the hand-held type, when the subject to be measured as a user urinates, the user holds the housing 10 in the hand and attaches it to the sensor unit 30 as shown in FIG. Make urine fall. Thereby, the sensor unit 30 can contact the urine excreted by the subject and acquire data representing the Na / K ratio.

  Alternatively, when the subject as a user urinates, a part of one urine 99 is collected in a disposable paper cup 97 as shown in FIG. The part 30 may be immersed in the urine 99 in the paper cup 97.

  Alternatively, when the subject as a user urinates, a part of one urine is impregnated into toilet paper (not shown), and the sensor unit 30 is impregnated into the toilet paper by holding the housing 10 in hand. It may be in contact with urine.

  Alternatively, when the subject as a user urinates, as shown in FIG. 2C, the urine 99 is collected in the toilet 98, and the sensor unit 30 is immersed in the urine collected in the toilet while holding the housing 10 in hand. You may. Even if water is present in the toilet 98 in advance and the urine 99 is diluted, the fact that the urine 99 is diluted does not affect the obtained Na / K ratio.

  In any case, according to the urine component analyzer of the hand-held type, a calculation result described later can be obtained by a simple operation.

  As shown in FIG. 2 (D), the sensor portion 30 is a flexible extension between the housing 10 and a plastically deformed and bent state when a force is applied by a subject as a user. It is desirable to have 31. By bending the extension 31, the subject as a user can drop urine on the sensor unit 30 in a comfortable posture when urinating.

  The control unit 11 shown in FIG. 1 includes a CPU (Central Processing Unit) operated by software, and performs various processes described later as a calculation unit, a data correction unit, and the like.

  The data input unit 12 inputs data representing the Na / K ratio in urine acquired by the sensor unit 30 in real time in this example. The data input unit 12 once inputs data representing the respective concentrations of sodium and potassium in one urine excreted by the subject, and before the correction described later, the ratio between them (Na / K ratio). ) May be taken.

The operation unit 13 includes a scroll button 13A shown in FIG. 2A and functions to input various information from the user. The input information includes information indicating the attribute of the subject (in this example, the ethnic group to which the subject belongs). Other information to be input includes the ethnic group to which the subject belongs, the area where the subject resides , whether the subject has a lifestyle-related disease such as hypertension or diabetes, or It may include information such as what kind of medicine the subject is taking.

  The storage unit 14 is composed of an EEPROM (electrically rewritable nonvolatile memory) in this example, and includes a correlation storage unit 15, a candidate correction amount storage unit 19, a measurement target data storage unit 20, an operation result storage unit 16, and An advice table 17 is included.

  For example, as shown in FIGS. 6A and 6B and FIGS. 7A and 7B, the correlation storage unit 15 stores the Na / K ratio in one urine excreted by a human or a plurality of times. The correlation between the mean Na / K ratio obtained using urine and the Na / K ratio in whole urine when all the urine excreted by a human on one or more days is collected into one is shown. The data to be represented is stored as a linear approximation formula. 6 (A) and 6 (B) to 7 (A) and 7 (B), scatter diagrams of actually measured data are omitted, and only straight lines obtained as a result of approximation are shown. With respect to the horizontal axis (x-axis), the average Na / K ratio means an average value obtained by averaging the actually measured Na / K ratios of urine a plurality of times as statistical processing. Instead of the average Na / K ratio, the median value of the Na / K ratio of urine for a plurality of times can be used. On the vertical axis (y-axis), the actually measured Na / K ratio in the total urine of the subject is measured by collecting all the urine excreted by the subject into one (urine collection). Law, the same shall apply hereinafter).

Specifically, FIG. 6A shows the case where the urine in the morning time zone (from 0:00 to 8:00) is used, and the actually measured Na / K ratio of one urine or a plurality of urines is used. 7 shows the correlation CORgm, CORwm, CORbm between the average Na / K ratio obtained in the above and the actually measured Na / K ratio in whole urine for one or more days. The correlation CORgm represents a linear approximation formula when using urine in the morning time zone when the attribute of a human is “general” (including Asians). The correlation CORwm represents a linear approximation expression when urine in the morning time zone is used when the attribute of a human is “white”. The correlation CORbm represents a linear approximation equation when urine in the morning time zone is used when the attribute of a human is “black”. In this example, the equations for each straight line are calculated using the coefficients a and b.
CORgm; y = ax + b + 1.2
CORwm; y = ax + b + 0.9
CORbm; y = ax + b + 0.5
It is expressed as Here, the coefficient a is 0.9 to 1.3, and the coefficient b is -1.0 to +1.0 (the same applies hereinafter).

FIG. 6 (B) shows the case where urine in the daytime (from 8:00 to 16:00) is used, which is obtained by using the actually measured Na / K ratio of one urine or plural times of urine. 4 shows the correlation CORgd, CORwd, CORbd between the measured average Na / K ratio and the actually measured Na / K ratio in whole urine for one or more days. The correlation CORgd represents a linear approximation formula when urine in the daytime zone is used when the attribute of a human is “general”. The correlation CORwd represents a linear approximation formula when urine during the daytime is used when the attribute of a human is “white”. The correlation CORbd represents a linear approximation formula when urine during the daytime is used when the attribute of a human is “black”. In this example, the equations for each straight line are calculated using the coefficients a and b described above.
CORgd; y = ax + b
CORwd; y = ax + b-0.3
CORbd; y = ax + b−0.37
It is expressed as

FIG. 7A shows the case where urine in the night time zone (from 16:00 to 24:00) is used, which is obtained by using the actually measured Na / K ratio of one urine or a plurality of urines. 4 shows the correlation CORgn, CORwn, CORbn between the measured average Na / K ratio and the actually measured Na / K ratio in whole urine for one or more days. The correlation CORgn represents a linear approximation equation when urine in the daytime zone is used when the attribute of a human is “general”. The correlation CORwn represents a linear approximation formula when urine during the daytime is used when the attribute of a human is “white”. The correlation CORbn represents a linear approximation formula when urine in the daytime zone is used when the attribute of a human is “black”. In this example, the equations for each straight line are calculated using the coefficients a and b described above.
CORgn; y = ax + b + 0.7
CORwn; y = ax + b + 0.3
CORbn; y = ax + b + 0.2
It is expressed as

  FIG. 7 (B) shows the average Na / K ratio obtained by using the urine measured a plurality of times, and the actually measured one or more days when urine was used in all time periods of morning, day, and night. 9 shows the correlation CORgg, CORwg, CORbg between the Na / K ratio in total urine on a day. The correlation CORgg represents a linear approximation formula when all the urine in the morning, day, and night is used when the attribute of the human is “general”. The correlation CORwg represents a linear approximation formula when urine in all time periods of morning, day, night and night is used when the attribute of a human is “white”. The correlation CORbg represents a linear approximation formula when urine in all time periods of morning, day and night is used when the attribute of a human is “black”. Here, for the sake of simplicity, the notation of the expression of each straight line is omitted.

More specifically, FIGS. 8A and 8B show a correlation in a case where the number of urines is specified in addition to a human attribute and a time zone. Specifically, FIG. 8A shows the measured Na / K ratio of one urine in the morning time zone and the actually measured total urine of one day in the case where the attribute of the human is “general”. The correlation COR (1, 0, 0) between the Na / K ratio in FIG. The correlation COR (1, 0, 0) is a special case of the above-described correlation CORgm, and is expressed by a straight line equation:
COR (1,0,0); y = x
It is expressed as

FIG. 8 (B) shows the average Na / K ratio obtained using the urine measured four times and eight times in the morning time zone when the attribute of the human is “general”. The correlation COR (4,0,0) and COR (7,0,0) between the total urine Na / K ratio for one or more days are shown. These correlations COR (4, 0, 0) and COR (7, 0, 0) are special cases of the above-described correlation CORgm, and are each represented by a straight line equation.
COR (4,0,0); y = x + 0.1
COR (7,0,0); y = x + 0.1
It is expressed as

Further, FIG. 8B shows the average Na / K ratio obtained using urine twice in the morning time, three times in the daytime, and twice in the night time, and the actually measured one or more days. The correlation COR (2, 3, 2) between the Na / K ratio in whole urine is shown. This correlation COR (2,3,2) is a special case of the above-described correlation CORgg, and is expressed by a straight line equation:
COR (2,3,2); y = x + 0.05
It is expressed as

  As described above, the correlation storage unit 15 stores the correlation in a manner distinguishing according to the attributes of the human, the time zone, and the number of urines. By using the correlation according to these human attributes, time zones, and the number of times of urine for the conversion described below, it is possible to improve the accuracy of the calculated Na / K ratio in the whole urine for one or more days. it can.

  When the human attribute is “general”, “black”, or “white”, the correlation storage unit 15 stores the measured Na / K ratio in urine one or more times as needed and Alternatively, data indicating a correlation between the measured Na / K ratio in the whole urine for one or more days when all urine excreted on multiple days is collected into one is also stored.

  Although the case where a linear approximation equation is stored as data representing the correlation has been described as an example, the present invention is not limited to this. The correlation storage unit 15 may store other functions, a conversion database, and the like.

  The candidate correction amount storage unit 19 illustrated in FIG. 1 stores a candidate correction amount that is a candidate for correcting the Na / K ratio in one urine of the subject obtained through the data input unit 12. The information is stored separately according to the attribute of the human and the time zone.

  As described above, the present inventor has repeatedly measured and found that the Na / K ratio in a single human urine tends to increase or decrease depending on the time of day (this is referred to as “daily variation”). "). It was found that the daily fluctuation was repeated every day in a substantially constant pattern. FIG. 13 is a line graph C1, C2, and C3 showing the circadian variation indicated by the Na / K ratio in one urine of a human for each ethnic group (Asian, black, and white) as a human attribute. I have. As can be seen from FIG. 13, when a day is divided into three, the Na / K ratio in a single human urine is the average of the days when the single urine was excreted in any ethnic group. Relative to the typical Na / K ratio, it becomes relatively high in the morning hours from 0:00 to 8:00, becomes relatively low in the daytime hours from 8:00 to 16:00, and from 16:00 to 24:00 In the night time zone. The Na / K ratio itself in one urine is highest for Asians (graph C1), second highest for blacks (graph C2), and lowest for whites (graph C3). The magnitude (amplitude) of the circadian variation is slightly different for Asians (graph C1), blacks (graph C2), and whites (graph C3).

  Therefore, in this example, the candidate correction amount storage unit 19 in FIG. 1 stores the candidate correction amounts that are candidates for the above correction as ethnicities (Asian, black, and white) as attributes of humans for three times. It is stored separately according to the time zone (morning time zone, day time zone, night time zone).

Specifically, as shown in FIG. 14, in the case of an Asian (graph C1), the Na / K ratio in urine once in the morning time zone, the daytime zone, and the night time zone is the graph C1. The candidate correction amounts Δ1m, Δ1d, and Δ1n are prepared so as to approach the weighted average C1ave. In this example,
Δ1m = -0.8
Δ1d = + 0.3
Δ1n = −0.3
It is. Note that the broken-line graphs C1m, C1d, and C1n show the corrected Na / K ratio for each of the morning time zone, the day time zone, and the night time zone.

As shown in FIG. 15, in the case of a black person (graph C2), the Na / K ratio in urine once in the morning time zone, the daytime zone, and the night time zone becomes the weighted average C2ave of the graph C2. The candidate correction amounts Δ2m, Δ2d, and Δ2n are prepared so as to approach each other. In this example,
Δ2m = -0.9
Δ2d = + 0.3
Δ2n = -0.2
It is. Note that the broken-line graphs C2m, C2d, and C2n represent the corrected Na / K ratio for each of the morning time zone, the day time zone, and the night time zone.

Further, as shown in FIG. 16, in the case of Caucasian (graph C3), the Na / K ratio in urine once in the morning time zone, the daytime zone, and the night time zone is changed to the weighted average C3ave of the graph C3 The candidate correction amounts Δ3m, Δ3d, and Δ3n are prepared so as to approach each other. In this example,
Δ3m = -0.9
Δ3d = + 0.3
Δ3n = −0.3
It is. Note that the broken-line graphs C3m, C3d, and C3n show the corrected Na / K ratio for each of the morning time zone, the daytime zone, and the night time zone.

  As described above, the candidate correction amount storage unit 19 stores the candidate correction amounts separately according to the attribute of the person and the time zone. By selecting a candidate correction amount according to the attribute of the human and the time zone and using it for correction described later, it is possible to improve the accuracy of the calculated Na / K ratio in whole urine for one or more days. it can.

The measurement target data storage unit 20 illustrated in FIG. 1 stores, for example, the following measurement target data table.
(Measurement target data table)

  As can be understood from the above, the measurement target data table shows, for each subject, the Na / K ratio in one urine obtained over one or more days obtained through the data input unit 12 for each urine. Is stored as measurement data relating to the subject in association with the urination date and time when the urine was excreted, the measurement date and time when the Na / K ratio of the urine was measured, and the time period when the urine was excreted. Here, “m” in the time zone indicates a morning time zone, “d” indicates a daytime zone, and “n” indicates a night time zone. In addition, this measurement target data table stores a corrected Na / K ratio, which will be described later, in association with the Na / K ratio in each urine.

  The calculation result storage unit 16 shown in FIG. 1 stores the calculation result by the control unit 11 (Na / K ratio in the whole urine of one or more days of the subject, which will be described later), the date and time of urination, the date and time of measurement, and , And are sequentially stored in association with the time period of urination. For example, by reading the contents of the calculation result storage unit, the user can easily determine the tendency of the daily change of the Na / K ratio in the whole urine of the subject for one or more days. You can know.

  The advice table 17 stores, for example, as shown in FIG. 21, the Na / K ratio and the advice to the subject according to the Na / K ratio in association with each other. For example, if the Na / K ratio is in the range of 0.0-1.0, the advice of "ideal value" corresponds. If the Na / K ratio is in the range of 1.0-2.0, the advice of "the target has been achieved" corresponds. If the Na / K ratio is in the range of 2.0-2.5, the advice of "I'm just about to reach my goal" is responding. If the Na / K ratio is in the range of 2.5 to 3.0, the advice of "Be careful of dietary habits because the numerical value is high." If the Na / K ratio is 3.0 or more, the advice of "The numerical value is too high. Let's be careful about eating habits." Note that the division of the numerical range of the Na / K ratio in the advice table 17 is an example, and a setting in which the division of the numerical range is changed is possible.

  The display unit 18 is composed of an LCD (liquid crystal display element) (see FIG. 2A) in this example, and displays various information such as a calculation result by the control unit 11.

  The clock 41 counts the current date and time. Based on the output of the clock 41, the measurement date and time at which the sensor unit 30 measured the Na / K ratio of urine each time, the date and time of urination (in this example, coincide with the measurement date and time), and urination were performed. The measured time zone is recorded in the measurement target data table of the measurement target data storage unit 20.

  In this example, the alarm unit 44 includes a buzzer, and emits an alarm sound according to a control signal from the control unit 11.

  The network communication unit 42 transmits information from the control unit 11 to another device on the network via a wireless communication line such as 3G (third generation mobile communication system) or Wi-Fi (registered trademark) in this example (FIG. (Not shown), and receives information transmitted from another device (not shown) on the network and passes it to the control unit 11. This makes it possible to provide the user with health-related information in cooperation with other devices, for example, via the Internet. The communication line is not limited to wireless, but may be wired.

  The urine component analyzer 90 generally performs calculations as shown in FIG. 3 or FIG. 4 under the control of the control unit 11. The indications of "human →" and "measurement subject →" at the left end in FIGS. 3 and 4 indicate that the data in the row is derived from urine excreted by the "human" and the "measurement subject", respectively. It indicates that there is.

  FIG. 3 shows a flow of a calculation for calculating the Na / K ratio in the whole urine in one day based on the Na / K ratio in one urine excreted by the subject. Specifically, the Na / K ratio in one urine excreted by a human and the Na / K ratio in the whole urine of one day when all the urine excreted by a human in one day are collected into one Is stored in a predetermined storage unit (correlation storage unit 15). The Na / K ratio (data D1) in one urine excreted by the subject is input. The data D1 is corrected according to the time period during which one urine is excreted so as to reduce the influence of the daily fluctuation. Thereby, the corrected Na / K ratio in one urine of the subject (data D2) is obtained. Then, based on the data D2, the Na / K ratio in the total urine in one day when all the urine excreted in one day by the subject is collected using the above-described correlation. (Data D3) is obtained by conversion.

FIG. 4 shows a flow of a calculation for calculating the Na / K ratio in whole urine for one or more days based on the Na / K ratio in urine excreted plural times by the subject. . Specifically, the Na / K ratio in urine excreted multiple times by humans and the total urine on one or more days when all urine excreted by humans on one or more days are collected into one Data indicating the correlation between the inside and the Na / K ratio is stored in a predetermined storage unit (correlation storage unit 15). The Na / K ratio (data D1, D1 ',...) In one urine excreted by the subject is input. The data D1, D1 ',... Are corrected for each data in accordance with the time period during which one urine is excreted so as to reduce the influence of daily fluctuation. Thus, the corrected Na / K ratio (data D2, D2 ',...) In one urine of the subject is obtained. Subsequently, these data D2, D2 ',... Are averaged to obtain an average density ratio (data D2ave). Then, based on the data D2ave, using the above correlation, the Na in the total urine on one or more days when the subject collects all the urine excreted on one or more days. / K ratio (data D3) is obtained by conversion.

  FIG. 5 shows a flow for the urine component analyzer 90 to perform the calculation shown in FIG. 3 or FIG. 4 under the control of the control unit 11.

  i) First, as shown in step S101 in FIG. 5, when the user turns on a power switch (not shown), for example, the apparatus first enters an attribute designation mode for inputting the ethnicity as the attribute of the subject.

  In this attribute designation mode, the control unit 11 causes the display unit 18 to display options such as “general” (including Asians), “white”, and “black”. When the user rotates the scroll button 13A while these options are displayed, options such as “general”, “white”, and “black” are sequentially highlighted as selection candidates. For example, when the user presses the scroll button 13A while “General” is highlighted, the operation unit 13 functions as an attribute input unit, and “General” is input as the attribute of the subject. Alternatively, “Asian” may be displayed as an attribute designation option on the display unit 18 so that “Asian” can be directly designated.

  If the attribute specification mode is skipped (if no attribute is specified), it is handled as if "general" has been selected.

  In this example, it is assumed that the user selects “general” (including Asian) as the attribute of the subject.

  ii) When the specification of the attribute is completed, as shown in step S102 in FIG. 5, the apparatus enters a measurement target setting mode for setting a time period in which urine is to be excreted and the number of times of urine.

  In the measurement target setting mode, the control unit 11 first displays “morning time zone”, “daytime zone”, “night time zone”, “all hours in the morning, daytime, and night” and “no time zone designation” on the display unit 18. Is displayed. When these options are displayed, when the user rotates the scroll button 13A, "morning time zone", "day time zone", "night time zone", "all time zones in the morning, day, night and night", "time zone" Are sequentially highlighted as selection candidates. For example, if the user presses the scroll button 13A while "morning time zone" is highlighted, "morning time zone" is set as the time zone in which urine should be excreted.

  Subsequently, the control unit 11 causes the display unit 18 to display an option of the number of urines. For example, when the “morning time zone” is set in step S101, (1, 0, 0),..., (4, 0, 0),. A set of three numbers is sequentially displayed as in (0, 0). In addition, in the state where “all hours in the morning, day, night and night” is set in step S101, (1, 1, 1),..., (2, 3, 2),. Thus, one or more sets of three numbers are sequentially displayed. In the set of these three numbers, the numbers on the left, center, and right represent the number of urines to be measured in the morning time, daytime, and night time zones, respectively. When the user presses the scroll button 13A while a desired set of numbers is displayed, the set of numbers displayed at that time is set as the urine count.

  If the measurement target setting mode is skipped, "no time zone is specified", that is, one or more times of urine at any time becomes a measurement target.

  In this example, the user selects “morning time zone” as the time zone in which urine is to be excreted, and selects once or seven times as the number of urines. That is, (1,0,0) urine or (7,0,0) urine is set as the measurement target. Such settings of the measurement target are stored in the storage unit 14.

  iii) Next, as shown in step S103 in FIG. 5, the urine measurement mode is entered. In this urine measurement mode, the user drops the urine 99 on the sensor unit 30 and presses the scroll button 13A in the time zone set in step S102 (“morning time zone” in this example) (FIG. 2A). reference). Then, in this example, the sensor unit 30 acquires data representing the Na / K ratio in one urine 99, and the data input unit 12 inputs the data representing the Na / K ratio in real time. The input Na / K ratio is stored in the measurement target data table of the measurement target data storage unit 20 in association with the urination date and time, the measurement date and time, and the time period of urination.

  Note that, in this example, the urination date and time match the measurement date and time. However, in a case where the urine excreted by the subject is stored each time, and the measurement is performed at a fixed time of the day, the date and time of urination and the date and time of measurement are shifted. In this case, the user manually inputs the date and time of urination via the operation unit 13. Based on the manually input urination date / time, the urination date / time and the time period of urination are stored in the measurement target data table of the measurement target data storage unit 20.

  iv) Next, as shown in step S104 in FIG. 5, the process enters the correction mode. In this correction mode, the control unit 11 functions as a data correction unit, and the Na / K ratio in one urine of the subject obtained through the data input unit 12 is represented by the Na / K ratio indicated by the Na / K ratio. The correction is made according to the time period during which one urine is excreted so as to reduce the influence of the fluctuation.

  Specifically, the control unit 11 refers to the candidate correction amount storage unit 19 and selects a candidate correction amount according to the time period during which one urine is excreted. In this example, "general" (including Asian) is input as an attribute (step S101), and one urine is excreted in the "morning time zone" (step S103). The candidate correction amount Δ1m = −0.8 shown in FIG. Then, the control unit 11 adds the candidate correction amount Δ1m to the Na / K ratio in one urine of the subject obtained via the data input unit 12 to obtain the corrected Na / K ratio. Ask. For example, if the Na / K ratio in one urine of the subject obtained through the data input unit 12 is 4.5, the corrected Na / K ratio is 3.7.

  v) As shown in step S105 in FIG. 5, the corrected Na / K ratio is measured in association with the urination date and time, the measurement date and time, the urination time zone, and the input Na / K ratio. It is stored in the measurement target data table of the target data storage unit 20.

  vi) Next, as shown in step S106 in FIG. 5, the control unit 11 refers to the measurement target data table in the measurement target data storage unit 20, and determines whether or not the data of the measurement target has been prepared.

  Here, if the measurement target is, for example, urine of (1, 0, 0), it is determined that the data of the measurement target has been prepared in the above-mentioned single urine data (YES in step S106), and step S108 is skipped. Then, the process proceeds to step S109 described below.

  On the other hand, if the measurement target is urine of (7, 0, 0), it is determined that the data of the measurement target is not yet collected in the above-mentioned single urine data (NO in step S106). In this case, as shown in step S107, the control unit 11 functions as a urination recommendation notification unit, and displays the recommended urination date and time at which the subject should urinate on the display unit 18 to notify the user. The display of the recommended urination date and time at which the subject should urinate is, for example, a message such as "Please urinate and measure during the time period from 0:00 to 08:00 on Tuesday, May 1, 2012." And Alternatively, in addition to or in addition to the above, an operation of sounding an alarm sound at the urination recommendation date and time by the alarm unit 44 may be performed. Alternatively, an operation of transmitting a mail urging urination to the subject by the network communication unit 42 at the urination recommendation date and time may be executed. In this case, the subject is urged to perform urination and measurement on the date and time when the e-mail is received on his / her mobile phone or smartphone, for example. By urging urination on the urination recommendation date and time, the subject as a user can easily repeat the processing of steps S103 to S105 in FIG.

  In this way, the measurement, data correction, and data storage for each urine are repeated (steps S103 to S105). If it is determined in step S106 that the data to be measured has been collected (YES in step S106), the process proceeds to step S108. move on.

  vii) Next, in step S108 in FIG. 5, the control unit 11 functions as a calculation unit, and averages the corrected Na / K ratios in urine as a statistical process to obtain an average Na / K ratio. obtain. This average Na / K ratio is to be converted.

  viii) Next, as shown in step S109 in FIG. 5, the control unit 11 functions as a calculation unit, and correction is performed for one urine stored in the measurement target data table of the measurement target data storage unit 20. Using the correlation stored in the correlation storage unit 15 based on the Na / K ratio or the average Na / K ratio corrected for a plurality of urines, all the subjects excreted on one or more days Is calculated by converting the Na / K ratio in the whole urine for one or more days when one urine is collected as one.

  Here, if the measurement target is urine of (1, 0, 0), the control unit 11 uses the correlation COR (1, 0, 0) shown in FIG. 8A for the above conversion. . If the measurement target is urine of (7, 0, 0), the correlation COR (7, 0, 0) shown in FIG. 8B is used for the above conversion.

  When the above conversion is performed based on the corrected Na / K ratio of one urine (1, 0, 0), the flow of the calculation is as shown in FIG. When the above conversion is performed based on the corrected average Na / K ratio of the urine (7, 0, 0) seven times, the flow of the calculation is as shown in FIG.

  ix) As shown in step S110, the control unit 11 calculates the Na / K ratio in the whole urine for one or more days obtained by this conversion, based on the urination date and time (in the case of using data of a plurality of urines, (The date and time when urine was excreted the last time) and stored in the calculation result storage unit 16. At the same time, the control unit 11 causes the display unit 18 to display the Na / K ratio obtained by this conversion.

  x) Further, as shown in step S111, the control unit 11 refers to the advice table 17 (FIG. 21) and, together with the Na / K ratio obtained by the conversion, the Na / K ratio obtained by the conversion. Is selected and displayed on the display unit 18.

  As described above, in the urine component analyzer 90, the Na / K ratio in the whole urine for one or more days is determined based on the Na / K ratio in one or more times of urine excreted by the subject. Since it is obtained by conversion, it is not necessary to actually measure the amount of urine excreted by the subject. If the Na / K ratio in at least one urine excreted by the subject is obtained as input data, a conversion result is obtained. Therefore, according to the urine component analyzer 90, the Na / K ratio in the whole urine of one or more days excreted by the subject can be easily obtained. Moreover, in the urine component analyzer 90, the control unit 11 functions as a data correction unit, and the Na / K ratio in one urine of the subject obtained via the data input unit 12 is used to determine the daily fluctuation. In order to reduce the influence, the correction is made according to the time period in which urine is excreted once. As a result, the influence of daily fluctuation can be reduced for the above conversion target. Therefore, the Na / K ratio in the whole urine of one or more days excreted by the subject can be accurately obtained.

  In the above-described flow, the measurement, data correction, and data storage for each urine are repeated (steps S103 to S105), and when it is determined that the data to be measured is complete (YES in step S106), the average Na / The K ratio is obtained (step S108), and conversion is performed (step S109). However, the present invention is not limited to this. After all of the Na / K ratio data in the urine of a plurality of times to be measured are input and collected, the Na / K ratio data in the urine of the plurality of times is corrected. Alternatively, data for a plurality of times after the correction may be stored, an average Na / K ratio may be obtained, and conversion may be performed.

  FIGS. 9A and 9B show the case where the attribute of the subject is “general”, and the data of one urine in the morning time zone, that is, the urine of (1, 0, 0) is used as the measurement target. In this case, an example is shown in which the accuracy of the Na / K ratio in the whole urine of one day obtained by the conversion is compared with the presence or absence of the correction according to the above-mentioned time zone. Specifically, FIG. 9A is obtained by performing conversion using data of the Na / K ratio of one urine in the morning time zone without any correction according to the time zone. The Na / K ratio in whole urine (horizontal axis) for one day was determined by the Na / K ratio in whole urine (vertical axis) for 7 days (including the day of urination, the same applies hereinafter) actually measured by the urine collection method. The results obtained when the correlation coefficient is obtained in association therewith are shown. At this time, the correlation coefficient was r = 0.51. FIG. 9B is a graph showing the conversion of the data of the Na / K ratio of one urine in the morning time zone with the correction according to the time zone, and the conversion of all the data in one day obtained by the conversion. The results obtained when the correlation coefficient was determined by associating the Na / K ratio in urine (horizontal axis) with the Na / K ratio in whole urine for 7 days (vertical axis) actually measured by the urine collection method. ing. At this time, the correlation coefficient was r = 0.57. Therefore, it was verified that the accuracy of the Na / K ratio obtained by the conversion can be improved when the correction according to the time zone is performed, as compared with the case without the correction according to the time zone.

  FIGS. 10 (A) and (B) show the accuracy of the Na / K ratio in whole-day urine obtained by the same conversion as in FIGS. 9 (A) and (B), using a Brand-Altman plot. The comparison is shown by the presence or absence of the correction according to the above-mentioned time zone. Specifically, the horizontal axes in FIGS. 10A and 10B are the Na / K ratio in the total urine for 7 days actually measured by the urine collection method and the total urine in 1 day obtained by the above conversion. And the average value obtained by averaging the Na / K ratio in Table 1. The vertical axis in FIGS. 10 (A) and 10 (B) indicates the Na / K ratio in whole urine for 7 days actually measured by the urine collection method. A difference value obtained by taking a difference between the K ratio and the Na / K ratio in the whole urine of one day obtained by the above conversion is shown. 10A and 10B, the average of the difference values is represented as “bias”, and the 95% confidence interval of the difference value is represented as “upper limit” and “lower limit”. As can be seen from FIG. 10A, in the case without correction, the 95% confidence interval d1 of the difference value is 5.00. On the other hand, as can be seen from FIG. 10B, in the case where the correction is performed, the 95% confidence interval d1 ′ of the difference value is 4.62, and the variation error is reduced. Therefore, according to the Brand-Altman plot, it is possible to improve the accuracy of the Na / K ratio obtained by the conversion in the case where the correction according to the time zone is performed, as compared with the case without the correction corresponding to the time zone. Was verified.

  FIGS. 11A and 11B show the case where the attribute of the subject is “general” and the urine data of seven times in the morning time zone, that is, the urine of (7, 0, 0) is used as the measurement target. In this case, an example is shown in which the accuracy of the Na / K ratio in the whole urine of one or more days obtained by the conversion is compared with the presence or absence of the correction according to the above-mentioned time zone. Specifically, FIG. 11 (A) shows the average Na / K ratio obtained by averaging the data of the Na / K ratio of urine seven times in the morning time zone without any correction according to the time zone. After conversion using the average Na / K ratio, the Na / K ratio (horizontal axis) in the whole urine of one or more days obtained by the conversion was calculated for all seven days measured by the urine collection method. The results are shown when the correlation coefficient is determined in association with the Na / K ratio in urine (vertical axis). At this time, the correlation coefficient was r = 0.67. FIG. 11 (B) shows an average Na / K ratio obtained by averaging the data of the Na / K ratio of urine seven times in the morning time zone with correction according to each time zone. , And the Na / K ratio (horizontal axis) in one or more days of total urine obtained by the conversion is calculated based on the Na / K ratio in total urine for 7 days actually measured by the urine collection method. The results when the correlation coefficient is obtained in association with the K ratio (vertical axis) are shown. At this time, the correlation coefficient was r = 0.67. Therefore, in the comparison shown in FIGS. 11A and 11B, the Na / K ratio obtained by the conversion between the case with the correction according to the time zone and the case without the correction according to the time zone. Could not tell the difference in accuracy. The reason is that when the measurement target increases from urine of (1,0,0) to urine of (7,0,0), the accuracy (correlation coefficient r) itself is considerably high. It is thought that it is difficult to distinguish.

  FIGS. 12 (A) and (B) show the accuracy of the Na / K ratio in whole-day urine obtained by the same conversion as in FIGS. 11 (A) and (B), using a Brand-Altman plot. The comparison is shown by the presence or absence of the correction according to the above-mentioned time zone. Specifically, the horizontal axis in FIGS. 12A and 12B is the Na / K ratio in the total urine for 7 days actually measured by the urine collection method and the one or more days obtained by the above conversion. The average value obtained by averaging the Na / K ratio in the whole urine is shown, and the vertical axis in FIGS. 12 (A) and 12 (B) is the total urine measured for 7 days by the urine collection method. And the Na / K ratio in the whole urine of one or more days obtained by the above conversion and the difference value obtained by taking the difference. 12A and 12B, the average of those difference values is represented as “bias”, and the 95% confidence interval of the difference value is represented as “upper limit” and “lower limit”. As can be seen from FIG. 12A, when no correction is made, the bias of the difference value is −1.04. On the other hand, as can be seen from FIG. 12B, when there is correction, the bias of the difference value becomes 0.00, and the error is reduced. Therefore, according to the Bland-Altman plot, the accuracy of the Na / K ratio obtained by the conversion can be improved when the correction according to the time zone is performed, as compared with the case without the correction according to the time zone. I was able to verify that.

  FIGS. 17 (A) and 17 (B) show the case where the attribute of the subject is "black" and the data of one time urine is used as a measurement target, and the total urine in one day obtained by conversion is shown. , The accuracy of the Na / K ratio is compared with the presence or absence of the correction according to the above-mentioned time zone. Specifically, FIG. 17 (A) shows the result obtained by performing the conversion using the data of the Na / K ratio of one urine at any time without correction according to the time zone, and then obtaining 1 by the conversion. When the correlation coefficient was determined by associating the Na / K ratio in the total urine on the day (horizontal axis) with the Na / K ratio in the total urine for 7 days actually measured by the urine collection method (vertical axis). The results are shown. At this time, the correlation coefficient was r = 0.47. FIG. 17 (B) is a graph showing the result of conversion using the data of the Na / K ratio of one urine at any time with the correction according to the time zone, and the total urine in one day obtained by the conversion. Shows the result when the correlation coefficient was determined by associating the Na / K ratio (horizontal axis) with the Na / K ratio (vertical axis) in whole urine for 7 days actually measured by the urine collection method. . At this time, the correlation coefficient was r = 0.48. Therefore, in the comparison shown in FIGS. 17A and 17B, the Na / K ratio obtained by the conversion between the case with the correction according to the time zone and the case without the correction according to the time zone. The accuracy was not clearly distinguished.

  FIGS. 18 (A) and (B) show the accuracy of the Na / K ratio in whole-day urine obtained by the same conversion as in FIGS. 17 (A) and (B), using a Brand-Altman plot. The comparison is shown by the presence or absence of the correction according to the time zone. Specifically, the horizontal axes in FIGS. 18A and 18B are the Na / K ratio in the whole urine measured for 7 days by the urine collection method and the total urine in one day obtained by the above conversion. And the average value obtained by averaging the Na / K ratio in Table 1. The vertical axis in FIGS. 18 (A) and (B) indicates the Na / K ratio in the whole urine for 7 days actually measured by the urine collection method. A difference value obtained by taking a difference between the K ratio and the Na / K ratio in the whole urine of one day obtained by the above conversion is shown. 18A and 18B, the average of the difference values is represented as “bias”, and the 95% confidence interval of the difference value is represented as “upper limit” and “lower limit”. As can be seen from FIG. 18A, when no correction is made, the bias of the difference value is 0.34. On the other hand, as can be seen from FIG. 18B, when there is correction, the bias of the difference value becomes 0.00, and the error is reduced. Therefore, according to the Bland-Altman plot, the accuracy of the Na / K ratio obtained by the conversion can be improved when the correction according to the time zone is performed, as compared with the case without the correction according to the time zone. I was able to verify that.

  FIGS. 19 (A) and (B) show the case where the attribute of the subject is “Caucasian” and the data of one time urine is used as a measurement target, and the total urine in one day is obtained by conversion. , The accuracy of the Na / K ratio is compared with the presence or absence of the correction according to the time zone. Specifically, FIG. 19 (A) shows the result obtained by performing the conversion using the data of the Na / K ratio of urine at one time without any correction according to the time zone, and then performing the conversion. When the correlation coefficient was determined by associating the Na / K ratio in the total urine on the day (horizontal axis) with the Na / K ratio in the total urine for 7 days actually measured by the urine collection method (vertical axis). The results are shown. At this time, the correlation coefficient was r = 0.55. FIG. 19 (B) is a graph showing the result of the conversion using the data of the Na / K ratio of one urine at any time with the correction according to the time zone, and the total urine in one day obtained by the conversion. Shows the result when the correlation coefficient was determined by associating the Na / K ratio (horizontal axis) with the Na / K ratio (vertical axis) in whole urine for 7 days actually measured by the urine collection method. . At this time, the correlation coefficient was r = 0.56. Therefore, in the comparison shown in FIGS. 19A and 19B, the Na / K ratio obtained by the conversion between the case with the correction according to the time zone and the case without the correction according to the time zone. The accuracy was not clearly distinguished.

  FIGS. 20 (A) and (B) show the accuracy of the Na / K ratio in whole-day urine obtained by the same conversion as in FIGS. 19 (A) and (B), using a Brand-Altman plot. The comparison is shown by the presence or absence of the correction according to the time zone. Specifically, the horizontal axis in FIGS. 20A and 20B is the Na / K ratio in the total urine for 7 days actually measured by the urine collection method, and the total urine in 1 day obtained by the above conversion. And the average value obtained by averaging the Na / K ratios in Table 1. The vertical axis in FIGS. 20 (A) and (B) indicates the Na / K ratio in the whole urine for 7 days actually measured by the urine collection method. A difference value obtained by taking a difference between the K ratio and the Na / K ratio in the whole urine of one day obtained by the above conversion is shown. 20A and 20B, the average of the difference values is represented as “bias”, and the 95% confidence interval of the difference value is represented as “upper limit” and “lower limit”. As can be seen from FIG. 20A, when no correction is made, the bias of the difference value is -0.50. On the other hand, as can be seen from FIG. 20B, when correction is performed, the bias of the difference value becomes 0.00, and the error is reduced. Therefore, according to the Bland-Altman plot, the accuracy of the Na / K ratio obtained by the conversion can be improved when the correction according to the time zone is performed, as compared with the case without the correction according to the time zone. I was able to verify that.

  In the above embodiment, one day is divided into three time zones (morning time zone from 0:00 to 8:00, daytime zone from 8:00 to 16:00, and night time zone from 16:00 to 24:00). However, it is not limited to this. For example, one day may be divided into 24 time zones. In this case, based on the data in FIG. 14 (one measured Na / K ratio), the time-varying period (1 hour) is set so as to reduce the influence of the daily fluctuation (to approach the weighted average). A candidate correction amount is prepared. Then, a candidate correction amount corresponding to a time period in which one urine is excreted is selected and used for correction. As a result, the daily fluctuation indicated by the Na / K ratio in one urine of the subject can be more appropriately corrected.

In the above-described embodiment, the urine of (1,0,0) or the urine of (7,0,0) is used as the measurement target, but the present invention is not limited to this. Urine for "morning hours", urine for "day hours", urine for "night hours", urine for "all hours in the morning, day and night", urine for "no time zone specified", etc. Urine from various time zones can be used. Therefore, the subject can be released from the restriction that urine must be collected at a predetermined time. Further, the number of times of urine can be set variously.

  In the above-described embodiment, ethnic groups (general, white, and black) are distinguished as attributes of the human (and the subject), but the present invention is not limited to this. For example, as attributes of a human (and a subject), the area where the human resides (residence), whether or not the human has a lifestyle-related disease such as hypertension or diabetes, or how the human is Including whether or not you are taking any medicine. When distinguishing a region where a person lives as an attribute of the person, a GPS (Global Positioning System) is mounted on the housing 10 of the urine component analyzer 90, and when there is no input of the residence of the subject. The residence of the person to be measured may be determined by GPS.

  The above embodiment is an exemplification, and various modifications can be made without departing from the scope of the present invention. Each of the above-described embodiments can be realized independently, but combinations of the embodiments are also possible. In addition, various features in different embodiments can be independently realized, but combinations of features in different embodiments are also possible.

REFERENCE SIGNS LIST 10 housing 11 control unit 12 data input unit 13 operation unit 15 correlation storage unit 16 operation result storage unit 17 advice table 18 display unit 19 candidate correction amount storage unit 20 measurement target data storage unit 30 sensor unit 41 clock 42 network communication unit 44 alarm unit 90 urine component analyzer

Claims (7)

The concentration ratio between sodium and potassium in one urine excreted by a human, and the sodium-potassium concentration in the whole urine of the day when all the urine excreted by the human is collected in one day A correlation storage unit storing data representing a correlation between the concentration ratio of
The candidate correction amount for correcting the concentration ratio is distinguished according to the time period during which one urine is excreted so as to reduce the influence of the circadian variation indicated by the concentration ratio in one urine. A stored candidate correction amount storage unit;
A data input unit for inputting data representing the concentration ratio between sodium and potassium in one urine excreted by the subject;
With reference to the candidate correction amount storage unit, the 1st of the subject obtained via the data input unit using the candidate correction amount according to the time period during which one urine was excreted. A data correction unit for correcting the concentration ratio between sodium and potassium in urine of the times,
Using the correlation stored in the correlation storage unit based on the concentration ratio between sodium and potassium in the urine of the subject once corrected by the data correction unit, A calculating unit for converting the concentration ratio between sodium and potassium in the whole urine of the day when the measurer collects all urine excreted in one day. A urine component analyzer characterized by the above-mentioned. The urine component analyzer according to claim 1,
The correlation storage unit stores a statistical concentration ratio obtained by performing statistical processing on the concentration ratio between sodium and potassium in urine excreted over one or more days by the human, and Storing data representing a correlation between the concentration ratio of sodium and potassium in the whole urine for one or more days when all urine excreted over one or more days is collected into one. Yes,
The data input unit inputs data representing a concentration ratio between the sodium and potassium in the urine of one time excreted by the subject,
The data correction unit corrects the concentration ratio between sodium and potassium in the urine of the subject once obtained through the data input unit, for each data representing the concentration ratio ,
The arithmetic unit performs a statistical process on the concentration ratio between sodium and potassium in urine in a plurality of times corrected by the data correction unit to obtain a statistical concentration ratio, and the statistical concentration ratio is subjected to the conversion. A urine component analyzer characterized in that: The urine component analyzer according to claim 1 or 2,
The urine component analyzer according to claim 1, wherein the candidate correction amount is a correction amount that brings the concentration ratio in one urine closer to a representative value of circadian variation indicated by the concentration ratio in one urine. The urine component analyzer according to claim 3,
The candidate correction amount storage unit stores the candidate correction amount separately according to the attribute of the human,
An attribute input unit for inputting the attribute of the subject;
The data correction unit refers to the candidate correction amount storage unit, selects a candidate correction amount according to the attribute of the subject, and uses the candidate correction amount for the correction. The urine component analyzer according to any one of claims 1 to 3,
The correlation storage unit stores the correlation separately according to the time zone,
The urine component analyzer according to claim 1, wherein the calculation unit refers to the correlation storage unit and uses a correlation corresponding to a time period during which one urine is excreted for the conversion. The urine component analyzer according to claim 5,
The correlation storage unit stores the correlation separately according to the attribute of the human,
An attribute input unit for inputting the attribute of the subject;
The urine component analyzer according to claim 1, wherein the calculation unit refers to the correlation storage unit and uses the correlation according to the attribute of the subject for the conversion. The concentration ratio between sodium and potassium in one urine excreted by a human, and the sodium-potassium concentration in the whole urine of the day when all the urine excreted by the human is collected in one day The data representing the correlation between the concentration ratio of the is stored in a predetermined correlation storage unit,
The candidate correction amount for correcting the concentration ratio is distinguished according to the time period during which one urine is excreted so as to reduce the influence of the circadian variation indicated by the concentration ratio in one urine. Stored in the candidate correction amount storage unit,
The data representing the concentration ratio between sodium and potassium in one urine excreted by the subject is input,
With reference to the candidate correction amount storage unit, the sodium in the one-time urine of the subject is input using the candidate correction amount according to the time period during which the one urine is excreted. to correct the concentration ratio between potassium,
Based on the corrected concentration ratio between the sodium and potassium in the urine of the subject at one time, the subject is set to 1 using the correlation stored in the correlation storage unit. A urine component analysis method, wherein the urine component analysis method is characterized in that the concentration ratio between sodium and potassium in the whole urine of the day is calculated by converting all the urine excreted on the day into one.

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