JP6650158B1 - Oil composition for stabilizing storage of hydrogen peroxide - Google Patents

Abstract

A silicone oil composition for suppressing and stabilizing decomposition of hydrogen peroxide. An oil composition containing silicone oil for stabilizing storage of hydrogen peroxide, wherein the oil composition is a linear silicone represented by the following formula (1): It is applied to the inner wall. [Selection diagram] Fig. 1

Description

  The present invention relates to an oil composition, particularly to an oil composition containing silicone oil for stabilizing the storage of hydrogen peroxide.

  Hydrogen peroxide solution is used industrially as a bleaching agent, and is used as a bactericide in the food field. Oxitol containing 2.5 to 3.5 w / v% of hydrogen peroxide is used for medical purposes as a disinfectant.

  The liquid temperature of hydrogen peroxide increases due to the heat of decomposition, and the decomposition is accelerated. Patent Document 1 discloses a material suitable for hydrogen peroxide.

Ryo Kusakabe "Production, Properties and Handling of Hydrogen Peroxide" Journal of Japan Society of Paper Technology Vol.52 No.5 May 1998

  As disclosed in Patent Document 1, the material of the storage container that can be used for storing the hydrogen peroxide solution is limited, and the material of the storage container cannot be freely selected.

  The present inventors have made intensive studies and found that an oil composition containing silicone oil has an effect of stabilizing the storage of hydrogen peroxide, and thus completed the present invention.

The purpose of the present invention is
An oil composition containing a silicone oil, for stabilizing the storage of hydrogen peroxide,
The oil composition is to provide an oil composition that is applied to an inner wall of a container.

  By using this oil composition, regardless of the material of the container that stores the hydrogen peroxide solution, it becomes possible to stabilize the storage of hydrogen peroxide, and it is possible to store the hydrogen peroxide solution for a long time. .

FIG. 1 shows a graph of the residual ratio of hydrogen peroxide in each container in the example.

Definitions For convenience, certain terms used in the present application are collected here. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Unless otherwise stated in context, the singular forms “a”, “an”, and “the” include plural references.

  The numerical ranges and parameters given in the present invention are approximations, but the numerical values given in specific examples are described as accurately as possible. However, any numerical value inherently contains certain errors necessarily resulting from the standard deviation found in each test measurement. Also, as used herein, the term "about" generally means within 10%, 5%, 1% or 0.5% of a given value or range. Alternatively, the term "about" means within an acceptable standard error, as considered by one skilled in the art.

Oil composition The oil composition according to the present embodiment,
An oil composition containing a silicone oil, for stabilizing the storage of hydrogen peroxide,
The oil composition is an oil composition applied to the inner wall of the container. The oil composition may contain a pharmaceutically acceptable component (such as sterilized water) in addition to the silicone oil.

  As the silicone oil, a silicone oil having a kinematic viscosity at 25 ° C of 1,000 to 40,000 cSt can be used, preferably 2,000 to 30,000 cSt, more preferably 3,000 to 20,000 cSt. It is.

  The kinematic viscosity at 25 ° C. of the silicone oil can be measured according to JIS Z8803.

  As the silicone oil, preferably, a linear silicone represented by the following formula (1) can be used.

  In the above formula (1), each R independently represents an organic functional group that does not contain a functional group involved in a hydrosilylation addition reaction such as an alkenyl group and / or a SiH group, or a hydroxyl group. It may be different. x represents an integer of 10 to 1200. R preferably independently represents a monovalent hydrocarbon group or a hydroxyl group, more preferably represents an alkyl group or an aryl group, and further preferably represents a methyl group, an ethyl group, or a phenyl group.

  The linear silicone represented by the above formula (1) is a polydiorganosiloxane in which both ends are blocked with a triorganosilyl group, and is a polydialkylsiloxane, a polydiarylsiloxane, a polyalkylarylsiloxane, or a copolymer thereof. Combination is more preferable, polydimethylsiloxane or polymethylphenylsiloxane is further preferable, and polydimethylsiloxane in which R is all methyl groups is particularly preferable.

  In the present embodiment, examples of the storage container include, but are not limited to, a metal container, a plastic container, a glass container, a ceramic container, a rubber container, and a combination thereof. Containers made of materials that are not suitable for are included. Further, the shape and the purpose of use of the storage container are not particularly limited. In the present embodiment, the hydrogen peroxide solution refers to a solution in which hydrogen peroxide is dissolved in a solvent (for example, water), and may contain additives (for example, phosphoric acid and phenacetin) as necessary. Good.

  The resolution of hydrogen peroxide is the ratio of the concentration of hydrogen peroxide in the hydrogen peroxide solution after a specific storage period under a specific temperature condition to the concentration of hydrogen peroxide in the hydrogen peroxide solution before the start of storage ( (Percentage of remaining hydrogen peroxide). Storage is performed in a sealed state. The temperature conditions are not limited, but may be 35 ° C, 37 ° C, 40 ° C, or 60 ° C. The storage period is not limited, but may be one week, two weeks, three weeks, or four weeks, or may be four weeks or longer. The concentration of hydrogen peroxide in the hydrogen peroxide solution before the start of storage may be tested, for example, at any concentration in the range of 0.01 to 40% (w / v). The residual ratio of hydrogen peroxide in the storage container in which the oil composition according to the present embodiment is applied to the inner wall is a condition in which a solution containing 2.5 to 3.5 w / v% of hydrogen peroxide is sealed and stored at 60 ° C for 4 weeks. 70% or more, preferably 75% or more, more preferably 78% or more, and still more preferably 80% or more. The amount of hydrogen peroxide in the hydrogen peroxide solution can be determined by titration with a potassium permanganate solution according to the oxidol determination method of the Japanese Pharmacopoeia.

  In the present embodiment, the concentration of hydrogen peroxide in the hydrogen peroxide solution in the storage container is, for example, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.5, 1, 5, 10 , 15, 20, 25, 30, 35 or 40% and may be in the range between any two of the numerical values exemplified herein, for example, 0.01 to 40% (w / v), preferably , 0.05 to 30% (w / v).

Application The oil composition according to the present embodiment can be applied to a storage container using a spray or the like. Upon application, the oil composition may be dissolved in a suitable solvent. When applying the oil composition to the inner wall of the storage container, the oil composition can be applied to the inner wall of the storage container by spraying at an application amount of 0.02 to 0.2 mg / cm ² . After application to the inner wall of the storage container, the thickness of the oil composition may be made uniform using a tool such as a squeegee, and the silicone oil in the oil composition may be softened by heat treatment (for example, autoclave treatment). Alternatively, the thickness of the oil composition may be made uniform.

Stability Test of Hydrogen Peroxide Solution A stability test of a hydrogen peroxide solution was performed using a glass container coated with silicone oil and a glass container not coated with silicone oil. Silicone oil was purchased from Dow corning (product name: Dow Corning 360 Medical Fluid (12,500 cSt)). A hydrogen peroxide solution was added to each container, the container was sealed, and stored at 60 ° C. for 4 weeks. The residual ratio of hydrogen peroxide in the hydrogen peroxide solution after storage was measured. The hydrogen peroxide solution used was oxidol “KENAE” manufactured by Kenei Pharmaceutical Co., Ltd. (containing 2.5 to 3.5 w / v% of hydrogen peroxide, containing phosphoric acid and phenacetin). The amount of hydrogen peroxide in the hydrogen peroxide solution was detected by titration with a potassium permanganate solution according to the oxidol determination method of the Japanese Pharmacopoeia. The results are shown in FIG.

  In the case of a glass container not coated with silicone oil, the residual ratio of hydrogen peroxide was about 70%. Glass containers coated with silicone oil accounted for 78% or more. As a result, the glass container coated with silicone oil was able to suppress the decomposition of hydrogen peroxide more than the glass container coated with no silicone oil.

Claims (7)

An oil composition containing a silicone oil, for stabilizing the storage of hydrogen peroxide,
The silicone oil is a linear silicone represented by the following formula (1),
(In the above formula (1),
R independently represents an organic functional group that does not contain a functional group involved in the hydrosilylation addition reaction, a monovalent hydrocarbon group or a hydroxyl group;
Each R may be the same or different,
x represents an integer of 10 to 1200)
The oil composition, wherein the oil composition is applied to an inner wall of a container. The oil composition according to claim 1 , wherein R independently represents an alkyl group or an aryl group. The oil composition according to claim 2 , wherein R independently represents a methyl group, an ethyl group, or a phenyl group. The oil composition according to any one of claims 1 to 3 , wherein the linear silicone is a polydiorganosiloxane in which both ends are blocked with a triorganosilyl group. The oil composition according to claim 4 , wherein the polydiorganosiloxane is a polydialkylsiloxane, a polydiarylsiloxane, a polyalkylarylsiloxane, or a copolymer thereof. The oil composition according to claim 5 , wherein the polydiorganosiloxane is polydimethylsiloxane or polymethylphenylsiloxane. The oil composition according to claim 6 , wherein the polydimethylsiloxane is a polydimethylsiloxane in which Rs are all methyl groups.