JP6586192B1 - Skin protection composition - Google Patents
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- JP6586192B1 JP6586192B1 JP2018086760A JP2018086760A JP6586192B1 JP 6586192 B1 JP6586192 B1 JP 6586192B1 JP 2018086760 A JP2018086760 A JP 2018086760A JP 2018086760 A JP2018086760 A JP 2018086760A JP 6586192 B1 JP6586192 B1 JP 6586192B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
【課題】 容易かつ安価に製造可能であり、また、撥水性を与えつつ速乾性、低刺激性、液垂れ抑制性に優れた使いやすい皮膚保護用組成物を提供する。【解決手段】本発明によれば、皮膚保護用組成物であって、少なくとも２種類の直鎖状シロキサンを含み、前記少なくとも２種類の直鎖状シロキサンは、ポリシロキサンを含み、直鎖状シロキサンの合計量に対する前記ポリシロキサンの含有量は、６質量％以上である、皮膚保護用組成物が提供される。【選択図】なしPROBLEM TO BE SOLVED: To provide an easy-to-use skin protecting composition that can be easily and inexpensively manufactured and is excellent in quick-drying, low irritation, and dripping suppression while giving water repellency. According to the present invention, there is provided a skin protection composition comprising at least two types of linear siloxane, wherein the at least two types of linear siloxanes include polysiloxane, The composition for skin protection is provided, wherein the content of the polysiloxane with respect to the total amount of is 6% by mass or more. [Selection figure] None
Description
本発明は、肌に撥水作用を与える皮膚保護用組成物に関する。 The present invention relates to a composition for protecting skin that imparts water repellency to skin.
一般的に、人工肛門（ストマ）を付ける、また、胃瘻処置を受ける、など様々な外的要因を有する患者は、消化液などの刺激で皮膚トラブルを起こしやすいため、シリコーン油などの撥水保護成分を主原料とした化粧品又は液体絆創膏など（以下、撥水保護剤と呼ぶ）が用いられており、それら撥水保護剤が皮膚を覆うことで、外的要因から皮膚を保護し皮膚トラブルを未然に防止することができる。また、おむつを使用する老人や病人に対しても、排泄物や乾燥による皮膚トラブルを予防する目的で、撥水保護剤などが用いられている（特許文献１）。 In general, patients with various external factors, such as having a stoma or undergoing gastrostomy treatment, are prone to skin problems due to irritation of digestive fluids. Cosmetics or liquid adhesive bandages (hereinafter referred to as water repellent protective agents) that use protective ingredients as the main ingredient are used. These water repellent protective agents cover the skin, protecting the skin from external factors and causing skin problems. Can be prevented in advance. Moreover, a water repellent protective agent etc. are used also for the elderly and sick who use a diaper in order to prevent the skin trouble by excrement and drying (patent document 1).
しかしながら、撥水性、刺激性、速乾性、液垂れ性などを考慮した結果、溶剤、界面活性剤、防腐剤、安定剤、及びアクリル系粘着剤などの種々の添加剤を含むものが多く、肌に刺激を与え皮膚トラブルを起こす場合があり問題となっている。また、様々な成分を混ぜ合わせる工程は、各工程がデリケートであるために不良品が出やすく、生産管理を行うのが難しいとの問題もある。さらに、原料コストも嵩む傾向がある。 However, as a result of considering water repellency, irritation, quick drying, dripping, etc., many of them contain various additives such as solvents, surfactants, preservatives, stabilizers, and acrylic adhesives. It may cause irritation and cause skin problems. Further, the process of mixing various components has a problem that since each process is delicate, defective products are easily produced and it is difficult to perform production management. Furthermore, raw material costs tend to increase.
本発明は、上記の事情を考慮したものであり、容易かつ安価に製造可能であり、また、撥水性を与えつつ速乾性、低刺激性、液垂れ抑制性に優れた使いやすい皮膚保護用組成物を提供することを目的とする。 The present invention takes the above-mentioned circumstances into consideration, and can be easily and inexpensively manufactured, and is an easy-to-use composition for skin protection excellent in quick-drying, low irritation, and dripping suppression while giving water repellency. The purpose is to provide goods.
本発明によれば、皮膚保護用組成物であって、少なくとも２種類の直鎖状シロキサンを含み、前記少なくとも２種類の直鎖状シロキサンは、ポリシロキサンを含み、直鎖状シロキサンの合計量に対する前記ポリシロキサンの含有量は、６質量％以上である、皮膚保護用組成物が提供される。 According to the present invention, there is provided a skin protecting composition comprising at least two types of linear siloxanes, the at least two types of linear siloxanes comprising polysiloxanes, based on the total amount of linear siloxanes. The composition for skin protection whose content of the said polysiloxane is 6 mass% or more is provided.
本発明者らは、鋭意研究を進めたところ、少なくとも２種類の直鎖状シロキサンを含み、そのうちの１種類の直鎖状シロキサンを特定の種類及び所定の含有量とすることで、その他の成分を含有しない場合でも上記目的が達成されることを見出し、本発明の完成に至った。 As a result of diligent research, the inventors of the present invention include at least two types of linear siloxane, and by setting one type of linear siloxane to a specific type and a predetermined content, other components are included. The present inventors have found that the above-described object can be achieved even in the case of not containing A, and completed the present invention.
以下、本発明の種々の実施形態を例示する。以下に示す種々の実施形態は互いに組み合わせ可能である。
好ましくは、前記少なくとも２種類の直鎖状シロキサンは、低分子シロキサンを含む。
好ましくは、前記ポリシロキサンの複数のケイ素原子の各々は、炭素数１〜６の有機基を有する。
好ましくは、前記低分子シロキサンは、ヘキサメチルジシロキサンである。
好ましくは、前記ポリシロキサンは、ジメチルポリシロキサンである。
好ましくは、２種類の直鎖状シロキサンのみからなる。
Hereinafter, various embodiments of the present invention will be exemplified. The various embodiments described below can be combined with each other.
Preferably, the at least two types of linear siloxanes include low molecular siloxanes.
Preferably, each of the plurality of silicon atoms of the polysiloxane has an organic group having 1 to 6 carbon atoms.
Preferably, the low molecular siloxane is hexamethyldisiloxane.
Preferably, the polysiloxane is dimethylpolysiloxane.
Preferably, it consists only of two types of linear siloxane.
以下、本発明を詳細に説明する。 Hereinafter, the present invention will be described in detail.
＜皮膚保護用組成物＞
本発明の皮膚保護用組成物は、少なくとも２種類の直鎖状シロキサンを含み、少なくとも２種類の直鎖状シロキサンは、ポリシロキサンを含み、直鎖状シロキサンの合計量に対するポリシロキサンの含有量は、６質量％以上である。
<Skin protection composition>
The skin protection composition of the present invention contains at least two types of linear siloxane, at least two types of linear siloxane contain polysiloxane, and the content of polysiloxane with respect to the total amount of linear siloxane is , 6% by mass or more.
＜直鎖状シロキサン＞
本発明の皮膚保護用組成物は、少なくとも２種類の直鎖状シロキサンを含むことにより、容易かつ安価に製造可能である。
<Linear siloxane>
The skin protecting composition of the present invention can be easily and inexpensively produced by containing at least two types of linear siloxane.
「シロキサン」は、ケイ素と酸素による骨格を有する化合物、すなわちシロキサン結合を有する化合物を意味し、下記一般式（１）により表される。「直鎖状シロキサン」とは、シロキサン結合により構成される骨格が、環状構造及び分岐構造を形成していない化合物を意味する。本発明の皮膚保護用組成物は、速乾性、液垂れ性、刺激性を考慮し、環状構造及び分岐構造を含まないことが特に好ましい。 “Siloxane” means a compound having a skeleton of silicon and oxygen, that is, a compound having a siloxane bond, and is represented by the following general formula (1). “Straight chain siloxane” means a compound in which a skeleton composed of siloxane bonds does not form a cyclic structure or a branched structure. The skin protecting composition of the present invention is particularly preferably free from a cyclic structure and a branched structure in consideration of quick drying, dripping and irritation.
上記一般式（１）において、Ｒ１の各々は互いに同じでも異なっていてもよい有機基である。Ｒ１は、好ましくは炭素数１〜６の有機基であり、より好ましくは炭素数１〜６のアルキル基であり、さらに好ましくは炭素数１のアルキル基、すなわちメチル基である。
ｎは、０以上である。
In the general formula (1), each of R 1 is an organic group which may be the same as or different from each other. R 1 is preferably an organic group having 1 to 6 carbon atoms, more preferably an alkyl group having 1 to 6 carbon atoms, and still more preferably an alkyl group having 1 carbon atom, that is, a methyl group.
n is 0 or more.
本発明の皮膚保護用組成物は、当該組成物に含まれる少なくとも２種類の直鎖状シロキサンの１つとして、ポリシロキサンを含む。ここで、ポリシロキサンは、上記一般式（１）において、ｎが４以上であり、複数のシロキサン結合をポリマー構造の主鎖として有するシロキサンである。また、ポリシロキサンの複数のケイ素原子の各々は、置換基として上記Ｒ１を有する。好ましくは、複数のケイ素原子の各々が有する置換基は互いに同じである。 The skin protecting composition of the present invention contains polysiloxane as one of at least two kinds of linear siloxanes contained in the composition. Here, the polysiloxane is a siloxane having n of 4 or more in the general formula (1) and having a plurality of siloxane bonds as the main chain of the polymer structure. Each of the plurality of silicon atoms of the polysiloxane has R 1 as a substituent. Preferably, each of the plurality of silicon atoms has the same substituent.
ポリシロキサンについては、ｎは、好ましくは１０以上であり、より好ましくは１００以上であり、また２００以下である。また、ポリシロキサンの重量平均分子量は、好ましくは５００以上であり、より好ましくは５０００以上である。ポリシロキサンの重量平均分子量は、１０００００以下である。なお、重量平均分子量はゲルパーミエーションクロマトグラフィ（ＧＰＣ）（標準ポリスチレン換算）によって測定することができる。 For polysiloxane, n is preferably 10 or more, more preferably 100 or more, and 200 or less. The weight average molecular weight of the polysiloxane is preferably 500 or more, more preferably 5000 or more. The weight average molecular weight of the polysiloxane is 100,000 or less. The weight average molecular weight can be measured by gel permeation chromatography (GPC) (standard polystyrene conversion).
ポリシロキサンとしては、例えば、ジメチルシリコーンオイル、メチルフェニルシリコーンオイル、メチルハイドロジェンシリコーンオイルや各変性シリコーンオイルなどが挙げられる。なかでも容易に入手可能であり、安価であることから、ジメチルシリコーンオイルのジメチルポリシロキサンが好ましい。 Examples of the polysiloxane include dimethyl silicone oil, methylphenyl silicone oil, methyl hydrogen silicone oil, and various modified silicone oils. Among them, dimethylpolysiloxane of dimethyl silicone oil is preferable because it is easily available and inexpensive.
本発明の皮膚保護用組成物は、当該組成物に含まれる少なくとも２種類の直鎖状シロキサンの１つとして、好ましくは低分子シロキサンを含む。ここで、低分子シロキサンは、上記一般式（１）において、ｎが０〜３であるシロキサンである。低分子シロキサンは比較的低分子量であり、揮発性に優れる。また、低分子シロキサンの複数のケイ素原子の各々は、置換基として上記Ｒ１を有する。好ましくは、複数のケイ素原子の各々が有する置換基は互いに同じである。 The skin protecting composition of the present invention preferably contains a low molecular weight siloxane as one of at least two types of linear siloxanes contained in the composition. Here, the low molecular siloxane is a siloxane in which n is 0 to 3 in the general formula (1). Low molecular siloxane has a relatively low molecular weight and is excellent in volatility. Further, each of the plurality of silicon atoms of the low molecular siloxane has the above R 1 as a substituent. Preferably, each of the plurality of silicon atoms has the same substituent.
低分子シロキサンとしては、例えば、ヘキサメチルジシロキサン、オクタメチルトリシロキサン、デカメチルテトラシロキサン、ドデカメチルペンタシロキサンなどが挙げられる。なかでも、容易に入手可能であり、揮発性に優れるヘキサメチルジシロキサン（＝ジシロキサン）が好ましい。 Examples of the low molecular siloxane include hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, and dodecamethylpentasiloxane. Among these, hexamethyldisiloxane (= disiloxane) which is easily available and excellent in volatility is preferable.
本発明の皮膚保護用樹脂組成物に含まれる直鎖状シロキサンの合計量は、皮膚保護用樹脂組成物全量に対し、好ましくは５０〜１００質量％であり、より好ましくは７５〜１００質量％であり、さらに好ましくは９５〜１００質量％である。また、皮膚保護用樹脂組成物は、好ましくは２種又は２種以上の直鎖状シロキサンのみからなり、より好ましくは２種の直鎖状シロキサンのみからなる。皮膚保護用樹脂組成物が２種の直鎖状シロキサンのみからなる場合には、容易かつ安価に製造可能なだけでなく、溶剤、界面活性剤、防腐剤、安定剤、及びアクリル系粘着剤などのその他の成分を加える必要がない。すなわち、皮膚保護用樹脂組成物が２種類の直鎖状シロキサンのみにより構成される場合でも、本発明の効果を達成可能である。 The total amount of linear siloxane contained in the skin protecting resin composition of the present invention is preferably 50 to 100% by mass, more preferably 75 to 100% by mass, based on the total amount of the skin protecting resin composition. More preferably, it is 95-100 mass%. Further, the skin protecting resin composition is preferably composed of only two or more types of linear siloxanes, and more preferably is composed of only two types of linear siloxanes. When the skin-protecting resin composition is composed of only two types of linear siloxane, it can be easily and inexpensively manufactured, as well as solvents, surfactants, preservatives, stabilizers, acrylic adhesives, etc. There is no need to add other ingredients. That is, even when the skin protecting resin composition is composed of only two types of linear siloxane, the effects of the present invention can be achieved.
直鎖状シロキサンの合計量に対するポリシロキサンの含有量は、６質量％以上であり、好ましくは８質量％以上であり、より好ましくは１０質量％以上である。当該含有量が６質量％未満である場合には、液垂れが生じやすい。また、直鎖状シロキサンの合計量に対するポリシロキサンの含有量は、好ましくは５５質量％以下であり、より好ましくは４０質量％以下であり、さらに好ましくは２０質量％以下である。当該含有量が５５質量％を超える場合には、速乾性が低下しやすい。当該含有量は、具体的には例えば、６、７、８、９、１０、１５、２０、２５、３０、３５、４０、４５、５０、５５質量％であり、ここで例示した数値の何れか２つの間の範囲内であってもよい。 The content of polysiloxane with respect to the total amount of linear siloxane is 6% by mass or more, preferably 8% by mass or more, and more preferably 10% by mass or more. When the content is less than 6% by mass, dripping tends to occur. The content of polysiloxane with respect to the total amount of linear siloxane is preferably 55% by mass or less, more preferably 40% by mass or less, and further preferably 20% by mass or less. When the content exceeds 55% by mass, the quick drying property tends to be lowered. Specifically, the content is, for example, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55% by mass, and any of the numerical values exemplified here Or within a range between the two.
本発明の皮膚保護用組成物に含まれる少なくとも２種類の直鎖状シロキサンの１つが低分子シロキサンである場合には、直鎖状シロキサンの合計量に対する低分子シロキサンの含有量は、好ましくは４５〜９４質量％であり、より好ましくは６０〜９２質量％であり、さらに好ましくは８０〜９０質量％である。当該含有量は、具体的には例えば、４５、５０、５５、６０、６５、７０、７５、８０、８５、９０、９１、９２、９３、９４質量％であり、ここで例示した数値の何れか２つの間の範囲内であってもよい。 When one of at least two kinds of linear siloxanes contained in the skin protecting composition of the present invention is a low molecular siloxane, the content of the low molecular siloxane with respect to the total amount of the linear siloxane is preferably 45. It is -94 mass%, More preferably, it is 60-92 mass%, More preferably, it is 80-90 mass%. The content is specifically, for example, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 91, 92, 93, 94% by mass, and any of the numerical values exemplified here Or within a range between the two.
＜その他の成分＞
本発明の皮膚保護用組成物は、本発明の効果を損なわない範囲で、直鎖状シロキサン以外の成分を含んでもよい。含んでもよいその他の成分としては、保湿剤、抗菌剤、香料、フィラー、刺激性の低い溶剤等の添加剤が挙げられる。ただし、製造コスト、製造の容易性、肌への刺激等を考慮すると、その他の成分は含まないことが好ましい場合がある。
<Other ingredients>
The composition for skin protection of the present invention may contain components other than linear siloxanes as long as the effects of the present invention are not impaired. Other components that may be included include additives such as humectants, antibacterial agents, fragrances, fillers, solvents with low irritation and the like. However, in consideration of production cost, ease of production, irritation to skin, and the like, it may be preferable not to include other components.
以下、実施例を挙げて本発明を具体的に説明するが、本発明はこれら実施例に限定されるものではない。 EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated concretely, this invention is not limited to these Examples.
実施例及び比較例では、シロキサンとして、下記の（Ｓ−１）〜（Ｓ−４）を用いた。
（Ｓ−１）ヘキサメチルジシロキサン（特級：和光純薬工業株式会社製）
（Ｓ−２）ジメチルポリシロキサン（和光純薬工業株式会社製）
（Ｓ−３）シクロペンタシロキサン（ＫＦ−９９５：信越化学工業株式会社製）
（Ｓ−４）メチルトリメチルシロキサン（ＴＭＦ−１．５：信越化学工業株式会社製）
In Examples and Comparative Examples, the following (S-1) to (S-4) were used as siloxane.
(S-1) Hexamethyldisiloxane (special grade: manufactured by Wako Pure Chemical Industries, Ltd.)
(S-2) Dimethylpolysiloxane (Wako Pure Chemical Industries, Ltd.)
(S-3) Cyclopentasiloxane (KF-995: manufactured by Shin-Etsu Chemical Co., Ltd.)
(S-4) Methyltrimethylsiloxane (TMF-1.5: manufactured by Shin-Etsu Chemical Co., Ltd.)
上記の各シロキサンのみを用い、表１に記載した配合量（質量部）に従い混合し組成物を調製した。各組成物の評価を表１に示す。 Using only each of the above siloxanes, a composition was prepared by mixing according to the blending amount (parts by mass) described in Table 1. Table 1 shows the evaluation of each composition.
＜評価方法＞
各実施例及び比較例の組成物を、以下に記載の板上にスプレー塗布し、撥水性、速乾性を、及び液垂れ性の評価を行った。また、刺激性に関しては、以下に記述する感応テストにより評価を行った。評価結果が「Ｂ」以上である場合に効果が認められ、評価結果が「Ａ」以上であると、高い商品価値が認められる。
<Evaluation method>
The compositions of the examples and comparative examples were spray-coated on the plates described below, and water repellency, quick-drying properties and dripping properties were evaluated. In addition, the irritation was evaluated by the sensitivity test described below. An effect is recognized when the evaluation result is “B” or more, and a high commercial value is recognized when the evaluation result is “A” or more.
板上に、本願発明にかかる組成物をスプレー塗布した。スプレー量は、１プッシュ（約０．３ｍｌ）である。
（撥水性）
上記組成物が塗布された板上に流動性固体（「汚れ」とする）を載せ、湿ったペーパータオルで「汚れ」の除去を行った。そして、撥水性の評価を以下の評価基準にて評価した。
Ａ：滑らかに「汚れ」を除去できる。
Ｂ：塗布されていない状態より「汚れ」を除去しやすい。
Ｃ：塗布されていない状態と同等の「汚れ」の除去しやすさである。
（速乾性）
上記板の質量変化を測定し、板上に残存している本願発明に係る組成物の質量が板の質量に対して１.０％以下となるまでに要した時間（乾燥時間）を求めた。そして、速乾性の評価を以下の評価基準にて評価した。
Ａ：乾燥時間が３０秒未満である。
Ｂ：乾燥時間が３０秒以上１分間未満である。
Ｃ：乾燥時間が１分間以上である。
（液垂れ性）
スプレー塗布時の板は、水平（１８０℃）状態である。そして、３０秒経過後、板を水平状態から９０度傾斜させ、液垂れ性の評価を以下の評価基準にて評価した。
Ａ：液滴が生じない。
Ｂ：液滴が生じる。
Ｃ：液滴が生じて、板上を流れる。
（刺激性）
年齢１歳以上９０歳未満の肌状態が良好な日本人４０名に、各サンプル（実施例１、２、３、４、比較例１、２、３、４、５）をおむつ交換後に股部から臀部に渡って適量をスプレー塗布して感応テストを行った。感応テストとしては、２４時間以内にひりひりした感覚を生じたかを刺激の焦点として、下記の評価基準にて評価した。
Ａ：刺激がなかった。
Ｂ：やや刺激があった。
Ｃ：大きく刺激があった。
The composition according to the present invention was spray-coated on a plate. The amount of spray is 1 push (about 0.3 ml).
(Water repellency)
A flowable solid (referred to as “dirt”) was placed on a plate coated with the above composition, and “dirt” was removed with a wet paper towel. And the evaluation of water repellency was evaluated according to the following evaluation criteria.
A: The “dirt” can be removed smoothly.
B: Easier to remove “dirt” than uncoated state.
C: Ease of removal of “dirt” equivalent to a state where no coating is applied.
(Quick-drying)
The change in the mass of the plate was measured, and the time (drying time) required until the mass of the composition according to the present invention remaining on the plate was 1.0% or less with respect to the mass of the plate was determined. . And quick-drying evaluation was evaluated on the following evaluation criteria.
A: Drying time is less than 30 seconds.
B: Drying time is 30 seconds or more and less than 1 minute.
C: Drying time is 1 minute or more.
(Dripping)
The plate at the time of spray application is in a horizontal state (180 ° C.). And after 30 second progress, the board was inclined 90 degree | times from the horizontal state, and evaluation of dripping was evaluated on the following evaluation criteria.
A: No droplet is generated.
B: Droplets are generated.
C: A droplet is generated and flows on the plate.
(Irritant)
Each sample (Examples 1, 2, 3, 4, Comparative Examples 1, 2, 3, 4, 5) was exchanged to diapers after 40 babies with good skin condition between 1 year old and under 90 years old. A sensitive test was carried out by spraying an appropriate amount over the buttocks. As a sensitive test, the following evaluation criteria were evaluated with the focus of stimulation as to whether a tingling sensation occurred within 24 hours.
A: There was no irritation.
B: There was some irritation.
C: There was a great stimulus.
表１からわかるように、ジメチルポリシロキサンを含む２種類の直鎖状シロキサンを含み、ジメチルポリシロキサンの含有量が６質量％以上である場合には、撥水性を与えつつ、速乾性、液垂れ抑制性、低刺激性が良好であることがわかる（実施例１〜４）。
一方、比較例１では、ジメチルポリシロキサンの含有量が少なく、液垂れが十分に抑制されていない。また、比較例２及び３では、ジメチルポリシロキサンに代えて直鎖状ではないポリシロキサンを用いたところ、速乾性、液垂れ性、低刺激性に問題を生じた。比較例４及び５では、ヘキサメチルジシロキサンに変えて、シクロペンタシロキサン又はメチルトリメチルシロキサンを用いたところ、液垂れ性等に問題を生じた。すなわち、少なくとも２種類の直鎖状シロキサンを含み、そのうちの１種類の直鎖状シロキサンを特定の種類及び所定の含有量とすることで、その他の成分を含有しない場合でも本願発明の課題が達成される。
As can be seen from Table 1, when two kinds of linear siloxane containing dimethylpolysiloxane are included and the content of dimethylpolysiloxane is 6% by mass or more, quick drying and dripping while giving water repellency. It turns out that inhibitory property and hypoallergenicity are favorable (Examples 1-4).
On the other hand, in Comparative Example 1, the content of dimethylpolysiloxane is small, and dripping is not sufficiently suppressed. In Comparative Examples 2 and 3, when a non-linear polysiloxane was used in place of dimethylpolysiloxane, problems occurred in quick drying, dripping, and low irritation. In Comparative Examples 4 and 5, when cyclopentasiloxane or methyltrimethylsiloxane was used instead of hexamethyldisiloxane, there was a problem in the dripping property. That is, it contains at least two types of linear siloxane, and by setting one type of linear siloxane to a specific type and a predetermined content, the object of the present invention can be achieved even when other components are not included. Is done.
Claims (6)
少なくとも２種類の直鎖状シロキサンを含み、
前記少なくとも２種類の直鎖状シロキサンは、ポリシロキサン及び低分子シロキサンを含み、
直鎖状シロキサンの合計量に対する前記ポリシロキサンの含有量は、７〜５５質量％である、
撥水性皮膚保護用組成物。 A skin protecting composition comprising:
Including at least two types of linear siloxanes;
The at least two kinds of linear siloxanes include polysiloxane and low molecular siloxane,
The content of the polysiloxane with respect to the total amount of linear siloxane is 7 to 55% by mass ,
A composition for protecting water-repellent skin.
請求項１又は請求項２に記載の撥水性皮膚保護用組成物。 Each of the plurality of silicon atoms of the polysiloxane has an organic group having 1 to 6 carbon atoms,
The composition for water-repellent skin protection according to claim 1 or 2.
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| JP2018086760A JP6586192B1 (en) | 2018-04-27 | 2018-04-27 | Skin protection composition |
| PCT/JP2019/017979 WO2019208789A1 (en) | 2018-04-27 | 2019-04-26 | Composition for skin protection use |
| CN201980026732.9A CN112020347A (en) | 2018-04-27 | 2019-04-26 | Composition for skin protection |
| KR1020207031205A KR20210003768A (en) | 2018-04-27 | 2019-04-26 | Composition for skin protection |
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| JP4915493B2 (en) * | 2005-07-12 | 2012-04-11 | アルケア株式会社 | Skin protection agent for adhesive products |
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