JP6644728B2 - Cosmetic for wipe - Google Patents
Cosmetic for wipe Download PDFInfo
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- JP6644728B2 JP6644728B2 JP2017071966A JP2017071966A JP6644728B2 JP 6644728 B2 JP6644728 B2 JP 6644728B2 JP 2017071966 A JP2017071966 A JP 2017071966A JP 2017071966 A JP2017071966 A JP 2017071966A JP 6644728 B2 JP6644728 B2 JP 6644728B2
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- component
- copper
- extract
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- cosmetic
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- 239000002537 cosmetic Substances 0.000 title claims description 30
- 239000000284 extract Substances 0.000 claims description 40
- 239000000203 mixture Substances 0.000 claims description 16
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 12
- 239000010949 copper Substances 0.000 claims description 12
- 229910052802 copper Inorganic materials 0.000 claims description 12
- 150000001879 copper Chemical class 0.000 claims description 11
- 241000792914 Valeriana Species 0.000 claims description 10
- 235000017468 valeriana Nutrition 0.000 claims description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- 235000009337 Spinacia oleracea Nutrition 0.000 claims description 8
- 241000219315 Spinacia Species 0.000 claims description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 6
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 5
- -1 copper complex salts Chemical class 0.000 claims description 5
- 229940108925 copper gluconate Drugs 0.000 claims description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- 229930002875 chlorophyll Natural products 0.000 claims description 4
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- STIAPHVBRDNOAJ-UHFFFAOYSA-N carbamimidoylazanium;carbonate Chemical compound NC(N)=N.NC(N)=N.OC(O)=O STIAPHVBRDNOAJ-UHFFFAOYSA-N 0.000 claims description 2
- 229940099898 chlorophyllin Drugs 0.000 claims description 2
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- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
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- 150000004699 copper complex Chemical class 0.000 description 2
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- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 1
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- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
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- 229940069638 aloe vera leaf extract Drugs 0.000 description 1
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- WGLPTDWXNJFVTC-MCDZGGTQSA-N copper;(2r,3r,4s,5r)-2-(6-aminopurin-9-yl)-5-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]oxolane-3,4-diolate Chemical compound [Cu+2].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H]([O-])[C@H]1[O-] WGLPTDWXNJFVTC-MCDZGGTQSA-N 0.000 description 1
- LHBCBDOIAVIYJI-DKWTVANSSA-L copper;(2s)-2-aminobutanedioate Chemical compound [Cu+2].[O-]C(=O)[C@@H](N)CC([O-])=O LHBCBDOIAVIYJI-DKWTVANSSA-L 0.000 description 1
- BJKWDVRCNOATJS-UHFFFAOYSA-L copper;4,8-diacetyl-2,9a-dimethyl-7,9-dioxodibenzofuran-1,3-diolate Chemical compound [Cu+2].CC12C(=O)C(C(=O)C)C(=O)C=C1OC1=C2C([O-])=C(C)C([O-])=C1C(C)=O BJKWDVRCNOATJS-UHFFFAOYSA-L 0.000 description 1
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Description
本発明はふきとり用化粧料に関する。更に詳しくは、皮膚の角質除去を目的とする化粧料に関する。 The present invention relates to a cosmetic for wiping. More specifically, the present invention relates to a cosmetic for removing skin keratin.
皮膚の老化において、正常な新陳代謝においては垢となって落屑されるはずの角質層（以後老化角質と称する）が、落屑せず滞留する現象がしばしば見られるようになる。この老化角質は固く乾燥した状態をしており、保湿能も著しく低下しているものである。また老化角質には排泄されるべきメラニン色素も含まれている。それ故、老化角質が落屑せず滞留すると、角質層全体としても固く肥厚した状態となり、皮膚は潤いや滑らかさを失い、更には透明感の低下したくすみのある外観へと変化する。 In skin aging, a phenomenon in which the stratum corneum (hereinafter referred to as aging stratum corneum), which is supposed to become debris and debris in normal metabolism, stays without desquamation often appears. The aged keratin is in a hard and dry state, and its moisturizing ability is significantly reduced. Aging keratin also contains melanin pigments to be excreted. Therefore, if the aged stratum corneum stays without desquamation, the stratum corneum as a whole becomes firm and thickened, the skin loses moisture and smoothness, and further changes to a dull appearance with reduced transparency.
上記のような状況から、老化角質を除去することにより皮膚に本来の潤い、滑らかさを取り戻し、くすみを改善することができることが考えられる。この効果を目的とした化粧料がふきとり用化粧料である。なお、本発明の「ふきとり用化粧料」とは、主に老化角質を除去し、皮膚に本来の潤いや滑らかさを取り戻し、くすみを改善する目的で用いる化粧料をいう。 From the above situation, it is considered that the skin can be restored to its original moisture and smoothness by removing the dead skin cells, and dullness can be improved. Cosmetics intended for this effect are cosmetics for wiping. The “cosmetic for wiping” of the present invention refers to a cosmetic used mainly for removing aging keratin, restoring the original moisture and smoothness to the skin, and improving dullness.
この目的達成のために、従来、角質柔軟効果を期待して、スクラブ剤等で物理的に除去する方法（特許文献１）、水酸化カリウムや炭酸カリウム等のアルカリ成分を配合する方法（特許文献２）、ケミカルピーリングで使用されるα−ヒドロキシ酸を配合する方法等（特許文献３）化学的な溶解作用によるものや、角質除去効果を有する植物抽出物の配合等（特許文献４）が試みられてきた。 In order to achieve this purpose, conventionally, a method of physically removing with a scrubbing agent or the like (Patent Document 1) and a method of blending an alkali component such as potassium hydroxide or potassium carbonate (Patent Document 1) 2), methods of blending α-hydroxy acids used in chemical peeling (Patent Document 3) Attempts are made by chemical dissolution or blending of plant extracts having an exfoliating effect (Patent Document 4) I have been.
しかしながら、物理的に除去する方法や、酸やアルカリ等による化学的な溶解作用による角質除去は、皮膚刺激が強く、かゆみや赤みなどが生じる問題があった。
一方で、角質除去効果を有する植物抽出物による角質除去は、皮膚に対する刺激は弱いものの、角質除去効果については、未だ十分な効果が得られていない。
However, the method of physically removing or exfoliating by the chemical dissolving action of an acid, an alkali, or the like has a problem that skin irritation is strong and itching or redness occurs.
On the other hand, exfoliation by a plant extract having an exfoliating effect has little irritation to the skin, but a sufficient exfoliating effect has not yet been obtained.
一方、ヒレハリソウ属植物の抽出物は発毛効果やフケかゆみ防止、皮膚刺激緩和効果、抗炎症効果などの効果があることが報告されている（特許文献５、特許文献６）。オウレン抽出物やクチナシ抽出物は消炎効果や抗菌効果があることが知られており、幅広く化粧品に配合されている成分である（特許文献７、特許文献８）。グルコン酸銅、銅クロロフィル等は肌から摂取することで細胞賦活効果やコラーゲン、エラスチン産生効果などが知られている（特許文献９、特許文献１０）。しかし、これら成分の単独及び組み合わせにおいて、化粧料に配合したときに老化角質を取り除き易くする効果は知られておらず、示唆すらされていなかった。 On the other hand, it has been reported that an extract of a plant of the genus Valerian has an effect such as a hair growth effect, an anti-dandruff itching effect, a skin irritation relieving effect, and an anti-inflammatory effect (Patent Documents 5 and 6). It is known that a spinach extract and a gardenia extract have an anti-inflammatory effect and an antibacterial effect, and are components widely used in cosmetics (Patent Documents 7 and 8). Copper gluconate, copper chlorophyll, and the like are known to have a cell activating effect and a collagen and elastin producing effect when ingested from the skin (Patent Documents 9 and 10). However, the effects of these components alone or in combination that facilitate removal of aging keratin when formulated into a cosmetic have not been known or even suggested.
本発明は、上記従来技術に鑑みてなされたものであって、高い角質除去効果を有し、且つ刺激等の安全性上問題のないふきとり用化粧料を提供することを課題とする。 The present invention has been made in view of the above prior art, and has as its object to provide a cosmetic for wiping having a high exfoliating effect and having no safety problems such as irritation.
このような状況において、本発明者は鋭意研究を行った結果、
成分（Ａ）：ヒレハリソウ属植物の抽出物から選ばれる一種以上
成分（Ｂ）：オウレン抽出物、クチナシ抽出物から選ばれる一種以上
成分（Ｃ）：銅塩、銅錯体、銅錯塩から選ばれる一種以上
を併用することで上記課題を解決した。
In such a situation, the present inventor conducted intensive research, and as a result,
Component (A): One or more components selected from extracts of Periwinkle plants Component (B): One or more components selected from spinach extract and gardenia extract Component (C): One selected from copper salts, copper complexes, and copper complex salts The above problem was solved by using the above in combination.
本発明によれば、高い角質除去効果を有し、且つ安全性上問題のないふきとり用化粧料を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, it has a high exfoliating effect and can provide the cosmetics for wiping which have no problem in safety.
以下、本発明について更に詳しく説明する。なお、特段注釈のない限り、以下で成分の配合量を「％」で表示する場合は質量％を意味する。 Hereinafter, the present invention will be described in more detail. In addition, unless otherwise specified, when the compounding amount of a component is shown by "%" below, it means mass%.
本発明に用いられる成分（Ａ）のヒレハリソウ属植物とは、ムラサキ科ヒレハリソウ属のヨーロッパ原産の多年草植物で、ヨーロッパ〜西シベリア、中央アジアに分布している。ヒレハリソウ属に属する植物として具体的には、例えば、ヒレハリソウ（Ｓｙｍｐｈｙｔｕｍ ｏｆｆｉｃｉｎａｌｅ、英名「コンフリー」）及びオオハリソウ（Ｓｙｍｐｈｙｔｕｍ ａｓｐｅｒｕｍ Ｌｅｐｅｃｈｉｎ）、ドワーフ・コンフリー（Ｓｙｍｐｈｙｔｕｍ ｂｅｒｉｃｕｍ）等が挙げられる。本発明に用いられるヒレハリソウ属植物抽出物は、ヒレアリソウ属に属する植物の抽出物であれば特に制限はされない。ヒレハリソウ属植物抽出物を一種又は複数組み合わせて用いることもできる。上記ヒレハリソウ属に属する植物のうち、ヒレハリソウが好適に利用できる。 The component of the genus Valeriana of the component (A) used in the present invention is a perennial plant native to Europe belonging to the genus Valericaceae, distributed in Europe, western Siberia, and Central Asia. Specific examples of plants belonging to the genus Valeriana include, for example, Valeriana (Symphytum officinale, English name "Comfrey"), Valeriana (Symphytum asperum Lepechin), and Dwarf Comfrey (Symphytum bericum). The extract of the genus Valeriana used in the present invention is not particularly limited as long as it is an extract of a plant belonging to the genus Valeriana. The extract of the genus Valeriana can also be used alone or in combination. Among the plants belonging to the genus Valerium, Valeriana can be suitably used.
本発明においては、ヒレハリソウ属植物抽出物の抽出部位は特に限定されないが、葉・根茎・全草から得られた抽出物が好適に利用できる。中でも葉の抽出物は、高い角質除去効果が期待できるので好ましい。 In the present invention, the extraction site of the plant extract of the genus Valerian is not particularly limited, but extracts obtained from leaves, rhizomes and whole plants can be suitably used. Above all, a leaf extract is preferable since a high exfoliating effect can be expected.
本発明に用いられるヒレハリソウ属植物の抽出物の配合量は特に制限はないが抽出物純分として０．００００１％〜１．０％が望ましい。より好ましくは、０．０００１〜０．５％、更に好ましくは０．０００５〜０．２％である。この範囲であれは高い角質除去効果を維持しつつ、皮膚刺激も低く抑える事ができるので好ましい。市販の原料としては「ファルコレックス コンフリーＢ（一丸ファルコス）」等が挙げられる。 The amount of the extract of the genus Valeriana used in the present invention is not particularly limited, but is preferably 0.00001% to 1.0% as a pure extract. More preferably, it is 0.0001 to 0.5%, and still more preferably 0.0005 to 0.2%. This range is preferable because skin irritation can be suppressed while maintaining a high exfoliating effect. Commercially available raw materials include “Falcolex Comfrey B (Ichimaru Falcos)” and the like.
本発明に使用される成分（Ｂ）のオウレン抽出物は、金鳳花科オウレン属の多年草である黄連から抽出して得られる。本発明においては、オウレン抽出物の抽出部位は特に限定されないが、葉・根茎・全草から得られた抽出物が好適に利用できる。 The spinach extract of the component (B) used in the present invention is obtained by extracting from a perennial plant of the genus Orenaceae, Orenum. In the present invention, the extraction site of the spinach extract is not particularly limited, but extracts obtained from leaves, rhizomes and whole plants can be suitably used.
本発明に使用される成分（Ｂ）のクチナシ抽出物は、アカネ科クチナシ属クチナシから抽出して得られる。
本発明においては、クチナシ抽出物の抽出部位は特に限定されないが、葉・根茎・全草から得られた抽出物が好適に利用できる。
市販の原料としては「クチナシリキッド（一丸ファルコス）」「ファルコレックス クチナシＢ（一丸ファルコス）」等が挙げられる。
The gardenia extract of the component (B) used in the present invention is obtained by extracting from the gardenia gardenia genus Gardenia.
In the present invention, the extraction site of the gardenia extract is not particularly limited, but extracts obtained from leaves, rhizomes and whole plants can be suitably used.
Examples of commercially available raw materials include “Cutina Sirikid (Ichimaru Falcos)” and “Falco Rex Gardenia B (Ichimaru Falcos)”.
本発明に用いられる成分（Ｂ）のオウレン抽出物、クチナシ抽出物の配合量は特に制限はない。単独又は併用して用いることができ、目安として抽出物純分(併用した場合は合計量)として０．００００１％〜０．１％が望ましい。より好ましくは、０．００００５％〜０．０５％、更に好ましくは０．０００１％〜０．０３％である。この範囲であれは高い角質除去効果を維持しつつ、皮膚刺激も低く抑える事ができるので好ましい。 There are no particular restrictions on the amounts of the components of the component (B), the spinach extract and the gardenia extract. It can be used alone or in combination, and as a standard, 0.00001% to 0.1% as a pure extract (total amount when used in combination) is desirable. More preferably, it is 0.00005% to 0.05%, and still more preferably 0.0001% to 0.03%. This range is preferable because skin irritation can be suppressed while maintaining a high exfoliating effect.
本発明に用いられる成分（Ａ）、成分（Ｂ）の各抽出物の抽出方法は特に限定されないが、例えば乾燥したものであれば質量比で１〜１０００倍量、特に１０〜１００倍量の溶媒を用い、０℃以上、特に２０℃〜４０℃で１時間以上、特に３〜７日間行うのが好ましい。また、６０〜１００℃で１時間、加熱抽出しても良い。 The extraction method of each extract of the component (A) and the component (B) used in the present invention is not particularly limited. For example, if the extract is dried, it is 1 to 1000 times by mass, particularly 10 to 100 times by mass. It is preferable to use a solvent at 0 ° C. or higher, particularly at 20 ° C. to 40 ° C., for 1 hour or more, particularly for 3 to 7 days. Moreover, you may heat-extract at 60-100 degreeC for 1 hour.
本発明に用いられる成分（Ａ）、成分（Ｂ）の各抽出物の抽出溶媒は特に限定されない。有機溶媒、水又は熱水を用いて行い、必要に応じて、有機溶媒又は水との混合溶媒でも良く、更に、有機溶媒抽出と水抽出とが組み合わされて用いられる。有機溶媒としては、メタノール、エタノール、ｎ−ブタノール、アセトン、クロロホルム、酢酸エチル、ｎ−ヘキサン、１，３−ブチレングリコール、プロピレングリコール等が用いられる。中でも、有機溶媒抽出物が特に好ましい。また抽出条件は特に制限されるものはないが、通常は常温及び加熱抽出が好ましい。抽出後は濾過及び濃縮乾燥して、溶液状、ペースト状又は粉末として用いても良い。更に多くの場合は、そのままの状態で利用できるが、必要ならば、その効力に影響内範囲で脱臭、脱色等の精製処理を加えても良い。尚、脱臭、脱色等の精製処理手段としては、活性炭カラムなどを用いても良く、抽出物質により一般的に適用される通常の手段を任意に選択して行えば良い。
さらに必要により、濃縮、粉末化したものを適宜使い分けて用いることができる。
尚、本明細書中、「抽出物」を「エキス」という場合があるが、同義である。
The extraction solvent for each of the components (A) and (B) used in the present invention is not particularly limited. The reaction is performed using an organic solvent, water or hot water, and if necessary, a mixed solvent with an organic solvent or water may be used. Further, an organic solvent extraction and a water extraction are used in combination. As the organic solvent, methanol, ethanol, n-butanol, acetone, chloroform, ethyl acetate, n-hexane, 1,3-butylene glycol, propylene glycol and the like are used. Among them, organic solvent extracts are particularly preferred. The extraction conditions are not particularly limited, but usually, room temperature and heat extraction are preferred. After extraction, it may be filtered, concentrated and dried, and used as a solution, paste or powder. In many cases, it can be used as it is, but if necessary, a purification treatment such as deodorization or decolorization may be added within the range that affects the effect. In addition, as a purification treatment means such as deodorization and decolorization, an activated carbon column or the like may be used, and an ordinary means generally applied to an extracted substance may be arbitrarily selected.
If necessary, the concentrated and powdered ones can be appropriately used and used.
In the present specification, “extract” may be referred to as “extract”, but they have the same meaning.
本発明に使用される成分（Ｃ）の銅塩、銅錯体、銅錯塩は、ふきとり化粧料中で銅がイオン化された状態で存在することができれば特に制限されない。これらの中から一種以上が用いられ、例えば銅塩を複数、銅塩と銅錯体を併用することも可能である。具体的な成分としては、例えば、グルコン酸銅、ＰＣＡ銅、硫酸銅、アスパラギン酸銅、ウスニン酸銅、アデノシン三リン酸銅等の銅塩、銅クロロフィル、銅クロロフィリン等の銅錯体及びそれらの塩である銅錯塩が挙げられる。銅錯塩における塩としては、ナトリウム、カリウム、マグネシウム等が挙げられるが特に制限されない。
成分（Ｃ）は、これらの中でも特にグルコン酸銅、ＰＣＡ銅、銅クロロフィル、銅クロロフィリンナトリウムが好ましく、さらに好ましくはグルコン酸銅である。通常このような銅塩及び銅錯体は細胞賦活効果、ＡＴＰ合成やケラチン合成促進、コラーゲン産生促進などの目的で配合されることが多いが、本発明ではふきとり効果の向上と安全性の向上が確認された。
The copper salt, copper complex and copper complex salt of the component (C) used in the present invention are not particularly limited as long as copper can be present in the wiped cosmetic in a state of being ionized. One or more of these are used. For example, a plurality of copper salts and a copper salt and a copper complex can be used in combination. Specific components include, for example, copper salts such as copper gluconate, PCA copper, copper sulfate, copper aspartate, copper usnate, copper adenosine triphosphate, copper complexes such as copper chlorophyll, copper chlorophyllin, and salts thereof. The copper complex salt which is is mentioned. Examples of the salt in the copper complex salt include, but are not particularly limited to, sodium, potassium, and magnesium.
The component (C) is particularly preferably copper gluconate, copper PCA, copper chlorophyll, or sodium copper chlorophyllin, more preferably copper gluconate. Usually, such copper salts and copper complexes are often blended for the purpose of activating cells, promoting ATP synthesis and keratin synthesis, and promoting collagen production. However, in the present invention, it has been confirmed that the wiper effect and the safety are improved. Was done.
本発明に用いられる成分（Ｃ）の配合量は特に制限はないが、目安として例えば単独配合で（併用配合した場合は、その合計量）０．００１％〜１．０％、より好ましくは、０．００５〜０．７５％、更に好ましくは、０．０１〜０．５％が望ましい。この範囲であれば安全性・安定性がさらに望ましい。 The blending amount of the component (C) used in the present invention is not particularly limited, but as a guide, for example, a single blending (when combined, a total amount thereof) is 0.001% to 1.0%, more preferably, 0.005 to 0.75%, more preferably 0.01 to 0.5% is desirable. Within this range, safety and stability are more desirable.
本発明に使用される成分（Ｄ）中の塩基性アミノ酸は、特に制限されないが、アルギニン、ヒスチジン、リシン等が挙げられる。
成分（Ｄ）記載の成分は、少なくとの一種以上用いられ、複数成分を併用してもちいることもできる。角質除去効果が優れているという観点から、水酸化ナトリウム、水酸化カリウム、炭酸カリウム、炭酸水素カリウム、炭酸ナトリウム、炭酸水素ナトリウム、炭酸グアニジン、アルギニンが特に好ましい。
The basic amino acid in the component (D) used in the present invention is not particularly limited, but includes arginine, histidine, lysine and the like.
The components described in Component (D) are used in at least one kind, and a plurality of components can be used in combination. Sodium hydroxide, potassium hydroxide, potassium carbonate, potassium bicarbonate, sodium carbonate, sodium bicarbonate, guanidine carbonate, and arginine are particularly preferred from the viewpoint of excellent exfoliating effect.
本発明に用いられる成分（Ｄ）の配合は必須ではないが、成分（Ａ）〜（Ｃ）に更に加えることによって、ふきとり効果がより期待できる。その配合量は特に制限はないが、極微量で効果が期待できるが、より高い効果を期待する場合には、目安として例えば単独配合で（併用配合した場合は、その合計量）０．０００１％〜１．５％、より好ましくは、０．０００５〜１．２５％、更に好ましくは、０．００１〜１．０％が望ましい。 The blending of the component (D) used in the present invention is not essential, but by further adding it to the components (A) to (C), a more wiping effect can be expected. The compounding amount is not particularly limited, but the effect can be expected in a very small amount. However, when a higher effect is expected, for example, a single compound (when the compounded compound is used, the total amount) is 0.0001%. -1.5%, more preferably 0.0005-1.25%, even more preferably 0.001-1.0%.
本発明のふきとり用化粧料には、上記必須成分の他、必要に応じて本発明の効果を阻害しない質的、量的範囲内で、水、界面活性剤、多価アルコール、低級アルコール、増粘剤、水溶性高分子、防腐剤、キレート剤、薬効成分、油剤、シリコーン、酸化防止剤、紫外線吸収剤、香料、色素等、通常化粧品に用いられている成分も配合することができる。 In the wiper cosmetic of the present invention, in addition to the above essential components, water, a surfactant, a polyhydric alcohol, a lower alcohol, Components commonly used in cosmetics, such as a thickener, a water-soluble polymer, a preservative, a chelating agent, a medicinal ingredient, an oil, a silicone, an antioxidant, an ultraviolet absorber, a fragrance, and a pigment, can also be added.
本発明のふきとり化粧料の使用方法は特に限定されない。手にとってそのまま使用しても良いし、コットン、ガーゼ、パフ、不織布等の化粧用具を用いて使用しても良い。
本発明の効果を最大限に発揮できる最良の形態は、液状で、化粧用コットン等に含ませることができる状態のものである。また、そのふきとり用化粧料を含ませたコットン等で皮膚の老化角質を拭き取る様に使用することが、効果を最大限に発揮できる使用方法である。
The method of using the wipe-off cosmetic of the present invention is not particularly limited. It may be used as it is for the hand, or may be used with a cosmetic tool such as cotton, gauze, puff, non-woven fabric and the like.
The best mode for maximizing the effects of the present invention is a liquid state that can be contained in cosmetic cotton or the like. In addition, it is a usage method to maximize the effect by using the cotton or the like containing the wipe-off cosmetic to wipe off the dead skin cells.
もっとも、本願におけるふきとり用化粧料は、ある程度の粘性を有していてもその効果は失わない。皮膚により密着してふきとり効果を高めることも期待できる。その場合の粘度は、TVB−１０形粘度計（東機産業株式会社製）で測定した場合（２０℃、ロータ名称：M１、６０秒）、２ｍPa・ｓ（６０ｒｐｍ）〜１００００ｍPa・ｓ（０．６ｒｐｍ）のものが好ましい。 However, even if the cosmetic for wiping in the present application has a certain degree of viscosity, its effect is not lost. It can also be expected to improve the wiping effect by closely adhering to the skin. The viscosity in that case is measured by a TVB-10 type viscometer (manufactured by Toki Sangyo Co., Ltd.) (20 ° C., rotor name: M1, 60 seconds), 2 mPa · s (60 rpm) to 10000 mPa · s (0. 6 rpm) is preferred.
以下に実施例を挙げて、本発明を更に説明する。なお、これらは本発明を何ら限定するものではない。配合量は組成物全量に対する質量％である。 Hereinafter, the present invention will be further described with reference to examples. These do not limit the present invention at all. The compounding amount is% by mass based on the total amount of the composition.
実施例１〜１２および比較例１〜１１について、下記表１、２に示す処方のふきとり用化粧料を用いて効果試験を行った。
[ふきとり用化粧料の製法]
表中の成分Ｅを８０℃以上に加熱し溶解させた後、Ａ、Ｂ、Ｃ、Ｄを追加投入し溶解させ、ふきとり用化粧料を得た。尚、表中Ａ’、Ｂ’、Ｃ’は、それぞれＡ、Ｂ、Ｃに準じて投入した。また、溶解しにくい場合は適宜界面活性剤となじませて配合した。
About Examples 1-12 and Comparative Examples 1-11, the effect test was performed using the wipe-off cosmetics of the formulation shown in the following Tables 1 and 2.
[Production method of cosmetics for wipes]
After heating and dissolving the component E in the table at 80 ° C. or higher, A, B, C, and D were additionally added and dissolved to obtain a cosmetic for wiping. In addition, A ', B', and C 'in the table were introduced according to A, B, and C, respectively. When it was difficult to dissolve, it was appropriately blended with a surfactant.
「ふきとり効果」
「評価方法」
実施例処方及び比較例処方で作製した化粧水を用い、専門女性パネラー２０名に試料をランダムに使用させる方法を用いた。詳細には１つの試料について、洗顔後、化粧水を一定量含ませたコットンで半顔をふきとり、使用したコットンを２日間自然乾燥させ、コットンの汚れの程度を比較した。次回のふきとりテストは前回ふき取った後２週間間隔を空けてから実施した。
"Sweeping effect"
"Evaluation method"
Using a lotion prepared according to the prescription of the example and the prescription of the comparative example, a method of randomly using samples by 20 specialized female panelists was used. More specifically, for one sample, after washing the face, a half face was wiped with cotton containing a certain amount of lotion, and the used cotton was air-dried for 2 days, and the degree of stain on the cotton was compared. The next wipe test was performed two weeks after the last wipe.
[評価基準]
ふきとり後のコットンの汚れの程度を用いて老化角質の除去効果（角質除去効果）について一人５点満点で目視にて自己採点し、評価とし、その合計点を４段階に分け評価値とした。
[Evaluation criteria]
Using the degree of soiling of the cotton after wiping, the effect of removing aged keratin (exfoliating effect) was visually scored on a scale of 1 to 5 for each person, and the evaluation was made.
「安全性の評価」
「評価方法」
実施例処方及び比較例処方で作製した化粧水を用い、専門女性パネラー２０名に試料をランダムに使用させる方法を用いた。詳細には１つの試料について、洗顔後、化粧水を一定量含ませたコットンで半顔をふきとり、使用したコットンを２日間自然乾燥させ、コットンの汚れの程度を比較した。次回のふきとりテストは前回ふき取った後２週間間隔を空けてから実施した。
"Evaluation of safety"
"Evaluation method"
Using a lotion prepared according to the prescription of the example and the prescription of the comparative example, a method of randomly using samples by 20 specialized female panelists was used. More specifically, for one sample, after washing the face, a half face was wiped with cotton containing a certain amount of lotion, and the used cotton was air-dried for 2 days, and the degree of stain on the cotton was compared. The next wipe test was performed two weeks after the last wipe.
[評価基準]
ふきとり後２時間以内に感じたピリピリ感、かゆみ、赤みなどの変化について一人５点満点で自己採点し、評価とし、その合計点を４段階に分け評価値とした。
[Evaluation criteria]
The change in tingling, itching, redness, etc. felt within 2 hours after wiping was scored by one person on a scale of 5 out of 5 and evaluated. The total score was divided into four grades and evaluated.
比較例１〜３にあるように成分（Ａ）がない処方、及び成分Ａと同じような薬効効果で知られる他の植物エキスや、同じく抗炎症効果があるグリチルレチン酸２Ｋを代わりに用いた処方では満足のいく角質除去効果や安全性は得られなかった。比較例４〜６にあるように成分（Ｂ）がない処方、及び成分Ｂと同じような抗炎症効果や抗菌作用などがあるアロエベラ葉エキスやグレープフルーツエキスを用いた処方では満足のいく角質除去効果や安全性は得られなかった。比較例７〜９にあるように成分（Ｃ）がない処方、及び成分Ｃと同じような細胞賦活効果やコラーゲン産生効果があるアデノシン三リン酸２Ｎａやグルコースリン酸２Ｎａ成分に置き換えた処方では満足のいく角質除去効果や安全性は得られなかった。これらの結果から実施例にあるように成分（Ａ）、（Ｂ）、（Ｃ）、更には（Ｄ）を組み合わせる事によって、高い角質除去効果がある事がわかり、その効果は従来から知られているようにアルカリのふきとり用化粧料と（比較例１０、１１）よりも高い効果であることがわかった。また、高い角質除去効果に加え、従来からあるアルカリのふきとり用化粧料と比較しても高い安全性を有している事がわかった。 Formulations containing no component (A) as in Comparative Examples 1 to 3, and other plant extracts known to have the same medicinal effects as component A, and formulations using glycyrrhetinic acid 2K, which also has an anti-inflammatory effect, instead Did not provide satisfactory exfoliating effect and safety. Satisfactory exfoliating effect is obtained with the formulation containing no component (B) as in Comparative Examples 4 to 6, and the formulation using aloe vera leaf extract or grapefruit extract having the same anti-inflammatory effect and antibacterial effect as component B. And safety was not obtained. The formulations without the component (C) as in Comparative Examples 7 to 9, and the formulations replaced with 2Na adenosine triphosphate and 2Na glucose phosphate, which have the same cell activating effect and collagen producing effect as the component C, are satisfactory. No significant exfoliating effect or safety was obtained. From these results, it can be seen that by combining the components (A), (B), (C), and (D) as in the examples, a high exfoliating effect can be obtained, and the effect has been conventionally known. As described above, the effect was higher than that of the cosmetic for wiping off alkali (Comparative Examples 10 and 11). Moreover, in addition to the high exfoliating effect, it was also found that it had higher safety than conventional cosmetics for wiping off alkalis.
常法にて、各処方の組成物を作製した。いずれの処方においても本発明の効果を奏することが確認された。
（１）ふきとり用化粧料：処方例１
配合成分 配合量（％）
水 残量
コンフリーエキス＊１ ０．０１５
クチナシエキス＊４ ０．０００４
銅クロロフィリンナトリウム ０．５００
1、３-ブチレングリコール ５.０００
炭酸Ｎａ 適量
炭酸水素Ｎａ 適量
防腐剤 適量
グリセリン ５．００
エデト酸塩 ０．０５
ヒドロキシエチルウレア ２．００
合計（％） １００．００
The composition of each formulation was prepared by a conventional method. It was confirmed that the effects of the present invention were exhibited in any of the formulations.
(1) Cosmetic for wipes: Formulation example 1
Ingredients Amount (%)
Water remaining comfrey extract * 1 0.015
Gardenia extract * 4 0.0004
Copper chlorophyllin sodium 0.500
1,3-butylene glycol 5,000
Na carbonate appropriate amount Na hydrogen carbonate appropriate amount Preservative appropriate amount glycerin 5.00
Edetate 0.05
Hydroxyethylurea 2.00
Total (%) 100.00
（２）ふきとり化粧料：処方例２
配合成分 配合量（％）
水 残量
コンフリーエキス＊１ ０．０１５
クチナシエキス＊４ ０．０００５
ＰＣＡ銅 ０．１００
1、３-ブチレングリコール ５.０００
炭酸水素Ｎａ 適量
防腐剤 適量
グリセリン １．００
エデト酸塩 ０．０５
ラフィノース ２．００
ヒドロキシエチルセルロース ０．３
合計（％） １００．００
(2) Wiping cosmetics: Formulation Example 2
Ingredients Amount (%)
Water remaining comfrey extract * 1 0.015
Gardenia extract * 4 0.0005
PCA copper 0.100
1,3-butylene glycol 5,000
Na bicarbonate Appropriate preservative Appropriate glycerin 1.00
Edetate 0.05
Raffinose 2.00
Hydroxyethyl cellulose 0.3
Total (%) 100.00
表１、表２、処方例１、２中の＊1〜＊６は、以下のとおり。
＊１：ファルコレックス コンフリー Ｂ（一丸ファルコス）
＊２：センブリ抽出液ＳＫ（香栄興業）
＊３：オウレン抽出液ＢＧ30（丸善製薬）
＊４：ファルコレックス クチナシＢ（一丸ファルコス）
＊５：アロエベラ抽出液−ＪＣ（丸善製薬）
＊６：ファルコレックス グレープフルーツ（一丸ファルコス）
尚、各配合量は純分換算量である。
* 1 to * 6 in Tables 1 and 2 and Formulation Examples 1 and 2 are as follows.
* 1: Falco Rex Comfrey B (Ichimaru Falcos)
* 2: Assembly extract SK (Koei Kogyo)
* 3: Spinach extract BG30 (Maruzen Pharmaceutical)
* 4: Falco Rex Gardenia B (Ichimaru Falcos)
* 5: Aloe vera extract-JC (Maruzen Pharmaceutical)
* 6: Falco Rex grapefruit (Ichimaru Falcos)
In addition, each compounding amount is a pure content conversion amount.
本発明によれば、高い角質除去効果を有し、且つ安全性上問題のないふきとり用化粧料を提供することができる。
ADVANTAGE OF THE INVENTION According to this invention, it has a high exfoliating effect and can provide the cosmetics for wiping which have no problem in safety.
Claims (3)
成分（Ａ）：ヒレハリソウ属植物の抽出物から選ばれる一種以上
成分（Ｂ）：オウレン抽出物、クチナシ抽出物から選ばれる一種以上
成分（Ｃ）：銅塩、銅錯体、銅錯塩から選ばれる一種以上 A cosmetic composition for wiping, comprising the following components (A) to (C).
Component (A): One or more components selected from extracts of Periwinkle plants Component (B): One or more components selected from spinach extract and gardenia extract Component (C): One selected from copper salts, copper complexes, and copper complex salts that's all
成分（Ａ）：ヒレハリソウ属植物の抽出物から選ばれる一種以上
成分（Ｂ）：オウレン抽出物、クチナシ抽出物から選ばれる一種以上
成分（Ｃ）：グルコン酸銅、ＰＣＡ銅、銅クロロフィル及びその塩、銅クロロフィリン及びその塩から選ばれる一種以上 A cosmetic composition for wiping, comprising the following components (A) to (C).
Component (A): One or more components selected from extracts of the genus Valeriana component (B): One or more components selected from spinach extract and gardenia extract Component (C): Copper gluconate, PCA copper, copper chlorophyll and salts thereof , One or more selected from copper chlorophyllin and its salts
成分（Ｄ）：水酸化ナトリウム、水酸化カリウム、炭酸カリウム、炭酸水素カリウム、炭酸ナトリウム、炭酸水素ナトリウム、炭酸グアニジン、塩基性アミノ酸から選ばれる一種以上
The wipe-off cosmetic component (D) according to claim 1 or 2, further comprising component (D): sodium hydroxide, potassium hydroxide, potassium carbonate, potassium hydrogen carbonate, sodium carbonate, sodium hydrogen carbonate, guanidine carbonate, basic One or more selected from amino acids
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