JP6626446B2 - 薬学的に適切な芳香族カチオン性ペプチド - Google Patents

薬学的に適切な芳香族カチオン性ペプチド Download PDF

Info

Publication number
JP6626446B2
JP6626446B2 JP2016542948A JP2016542948A JP6626446B2 JP 6626446 B2 JP6626446 B2 JP 6626446B2 JP 2016542948 A JP2016542948 A JP 2016542948A JP 2016542948 A JP2016542948 A JP 2016542948A JP 6626446 B2 JP6626446 B2 JP 6626446B2
Authority
JP
Japan
Prior art keywords
acid
hexafluorophosphate
compound
hydrogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016542948A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017502956A5 (https=
JP2017502956A (ja
Inventor
ディー トラヴィス ウィルソン
ディー トラヴィス ウィルソン
Original Assignee
ステルス バイオセラピューティックス コープ
ステルス バイオセラピューティックス コープ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ステルス バイオセラピューティックス コープ, ステルス バイオセラピューティックス コープ filed Critical ステルス バイオセラピューティックス コープ
Publication of JP2017502956A publication Critical patent/JP2017502956A/ja
Publication of JP2017502956A5 publication Critical patent/JP2017502956A5/ja
Application granted granted Critical
Publication of JP6626446B2 publication Critical patent/JP6626446B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2016542948A 2013-12-27 2014-12-23 薬学的に適切な芳香族カチオン性ペプチド Active JP6626446B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361921376P 2013-12-27 2013-12-27
US61/921,376 2013-12-27
US201461947261P 2014-03-03 2014-03-03
US61/947,261 2014-03-03
PCT/US2014/072264 WO2015100376A1 (en) 2013-12-27 2014-12-23 Pharmaceutically relevant aromatic-cationic peptides

Publications (3)

Publication Number Publication Date
JP2017502956A JP2017502956A (ja) 2017-01-26
JP2017502956A5 JP2017502956A5 (https=) 2018-02-08
JP6626446B2 true JP6626446B2 (ja) 2019-12-25

Family

ID=53479676

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016542948A Active JP6626446B2 (ja) 2013-12-27 2014-12-23 薬学的に適切な芳香族カチオン性ペプチド

Country Status (6)

Country Link
US (2) US10221213B2 (https=)
EP (1) EP3087093B1 (https=)
JP (1) JP6626446B2 (https=)
CN (2) CN112457368A (https=)
CA (1) CA2935207C (https=)
WO (1) WO2015100376A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10221213B2 (en) * 2013-12-27 2019-03-05 Stealth Biotherapeutics Corp Pharmaceutically relevant aromatic-cationic peptides
EP3160984B1 (en) * 2014-06-25 2021-04-14 Flamma S.P.A. Process for preparing d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide
WO2016001042A1 (en) * 2014-06-30 2016-01-07 Flamma S.P.A. Process for the production of d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide
EP3265109B1 (en) 2015-03-06 2020-10-21 Stealth BioTherapeutics Corp Processes for preparing pharmaceutically relevant peptides
WO2017180535A1 (en) 2016-04-11 2017-10-19 Carnot, Llc Chiral peptides
EP3500286A4 (en) * 2016-08-16 2020-03-25 Stealth BioTherapeutics Corp N-CARBOXYANHYDRIDE-BASED SCALE SYNTHESIS OF ELAMIPRETID
US11034724B2 (en) 2017-04-05 2021-06-15 Stealth Biotherapeutics Corp. Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2
US20200361987A1 (en) * 2017-11-15 2020-11-19 Stealth Biotherapeutics Corp. Deuterated tetrapeptides that target mitochondria
US10676506B2 (en) 2018-01-26 2020-06-09 Stealth Biotherapeutics Corp. Crystalline bis- and tris-hydrochloride salt of elamipretide
CN108929371A (zh) * 2018-08-02 2018-12-04 哈尔滨师范大学 一种Phakellistatin13直链衍生物、其制备办法及用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2067000C1 (ru) 1994-06-29 1996-09-27 Владислав Исакович Дейгин Пептид и способ его получения
US6248716B1 (en) * 1995-06-27 2001-06-19 Immunotech Developments Inc. Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
US20030069231A1 (en) * 1999-10-12 2003-04-10 Klaus Rudolf Modified aminoacids, pharmaceuticals containing these compounds and method for their production
JP2004501875A (ja) * 2000-06-14 2004-01-22 メダレックス，インコーポレイティド トリペプチドプロドラッグ化合物
WO2007100652A2 (en) 2006-02-22 2007-09-07 Edison Pharmaceuticals, Inc. Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
US20070213505A1 (en) 2006-03-08 2007-09-13 David Epstein Solution Synthesis of Peptide Cell Growth Stimulators
EP3375449A1 (en) * 2010-03-15 2018-09-19 Stealth Peptides International, Inc. Combination therapies using cyclosporine and aromatic cationic peptides
CA2839408A1 (en) * 2011-06-14 2012-12-20 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
CN104244964A (zh) * 2012-02-22 2014-12-24 康肽德生物医药技术有限公司 用于预防或治疗眼科病状的方法和组合物
JP2016506391A (ja) 2012-12-06 2016-03-03 ステルス ペプチドズ インターナショナル インコーポレイテッド ペプチド治療薬およびその使用方法
JP2016539931A (ja) 2013-10-23 2016-12-22 株式会社カネカ テトラペプチド化合物及びその製造方法
US10221213B2 (en) * 2013-12-27 2019-03-05 Stealth Biotherapeutics Corp Pharmaceutically relevant aromatic-cationic peptides
JP2017512762A (ja) * 2014-03-03 2017-05-25 ステルス バイオセラピューティックス コープ 薬学的に妥当な芳香族カチオン性ペプチド及びその生成方法

Also Published As

Publication number Publication date
EP3087093B1 (en) 2021-11-10
CN112457368A (zh) 2021-03-09
EP3087093A1 (en) 2016-11-02
CA2935207A1 (en) 2015-07-02
CA2935207C (en) 2022-06-21
US10696716B2 (en) 2020-06-30
US10221213B2 (en) 2019-03-05
US20200024308A1 (en) 2020-01-23
EP3087093A4 (en) 2017-09-27
US20160340389A1 (en) 2016-11-24
CN106132984B (zh) 2020-12-08
WO2015100376A1 (en) 2015-07-02
JP2017502956A (ja) 2017-01-26
CN106132984A (zh) 2016-11-16

Similar Documents

Publication Publication Date Title
JP6626446B2 (ja) 薬学的に適切な芳香族カチオン性ペプチド
JP7450572B2 (ja) 薬学的に適切なペプチドを調製するための方法
JP2017512762A (ja) 薬学的に妥当な芳香族カチオン性ペプチド及びその生成方法
CA2801101C (en) Process for preparing a biphenyl-2-ylcarbamic acid
HK40049251A (en) Processes for preparing pharmaceutically relevant peptides
HK1230631B (en) Pharmaceutically relevant aromatic-cationic peptides
CA2412787A1 (en) Process for the preparation of 5-phenylpentanoyl-ala-argl-{2-[3-amino-2-oxopyrrolidin-1-yl]propionyl}-ala-arg-ala-4-aminophenylacetamide
HK1248604B (en) Processes for preparing pharmaceutically relevant peptides
HK1248604A1 (en) Processes for preparing pharmaceutically relevant peptides

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171222

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171222

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20181122

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190220

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190521

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20191031

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20191129

R150 Certificate of patent or registration of utility model

Ref document number: 6626446

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250