JP6595484B2 - 光損傷皮膚のパルス光力学的処置 - Google Patents

光損傷皮膚のパルス光力学的処置 Download PDF

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JP6595484B2
JP6595484B2 JP2016541353A JP2016541353A JP6595484B2 JP 6595484 B2 JP6595484 B2 JP 6595484B2 JP 2016541353 A JP2016541353 A JP 2016541353A JP 2016541353 A JP2016541353 A JP 2016541353A JP 6595484 B2 JP6595484 B2 JP 6595484B2
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photosensitizer
skin
pdt
ala
minutes
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JP2017504602A (ja
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ヴルフ，ハンス・クレスチャン
サンクレメンテ，グロリア
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ガルデルマ・リサーチ・アンド・デヴェロップメント
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0653—Organic light emitting diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0657—Natural light sources, e.g. captured sunlight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A61N2005/0663—Coloured light

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Radiation-Therapy Devices (AREA)
JP2016541353A 2013-12-20 2014-12-05 光損傷皮膚のパルス光力学的処置 Expired - Fee Related JP6595484B2 (ja)

Priority Applications (1)

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JP2019112853A JP6933685B2 (ja) 2013-12-20 2019-06-18 光損傷皮膚のパルス光力学的処置

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP13306826.2 2013-12-20
EP13306826 2013-12-20
EP14162516.0 2014-03-28
EP14162516 2014-03-28
PCT/EP2014/076796 WO2015091037A1 (en) 2013-12-20 2014-12-05 Pulse photodynamic treatment of photodamaged skin

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JP2019112853A Division JP6933685B2 (ja) 2013-12-20 2019-06-18 光損傷皮膚のパルス光力学的処置

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JP2017504602A JP2017504602A (ja) 2017-02-09
JP6595484B2 true JP6595484B2 (ja) 2019-10-23

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Application Number Title Priority Date Filing Date
JP2016541353A Expired - Fee Related JP6595484B2 (ja) 2013-12-20 2014-12-05 光損傷皮膚のパルス光力学的処置
JP2016541098A Pending JP2017505292A (ja) 2013-12-20 2014-12-19 皮膚症状のパルス光力学的処置
JP2016541085A Expired - Fee Related JP6639398B2 (ja) 2013-12-20 2014-12-19 座瘡のパルス光力学的処置
JP2019112853A Expired - Fee Related JP6933685B2 (ja) 2013-12-20 2019-06-18 光損傷皮膚のパルス光力学的処置
JP2019161856A Pending JP2020002160A (ja) 2013-12-20 2019-09-05 座瘡のパルス光力学的処置
JP2021133842A Pending JP2021183632A (ja) 2013-12-20 2021-08-19 光損傷皮膚のパルス光力学的処置

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JP2016541098A Pending JP2017505292A (ja) 2013-12-20 2014-12-19 皮膚症状のパルス光力学的処置
JP2016541085A Expired - Fee Related JP6639398B2 (ja) 2013-12-20 2014-12-19 座瘡のパルス光力学的処置
JP2019112853A Expired - Fee Related JP6933685B2 (ja) 2013-12-20 2019-06-18 光損傷皮膚のパルス光力学的処置
JP2019161856A Pending JP2020002160A (ja) 2013-12-20 2019-09-05 座瘡のパルス光力学的処置
JP2021133842A Pending JP2021183632A (ja) 2013-12-20 2021-08-19 光損傷皮膚のパルス光力学的処置

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US (6) US10716855B2 (enExample)
EP (4) EP3082787B1 (enExample)
JP (6) JP6595484B2 (enExample)
CN (3) CN105899201A (enExample)
BR (3) BR112016014073A2 (enExample)
ES (1) ES2709446T3 (enExample)
WO (3) WO2015091037A1 (enExample)

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CN105899201A (zh) * 2013-12-20 2016-08-24 盖尔德马研究及发展公司 光损伤的皮肤的脉冲光动力治疗
US10603508B2 (en) 2015-10-15 2020-03-31 Dusa Pharmaceuticals, Inc. Adjustable illuminators and methods for photodynamic therapy and diagnosis
WO2017066270A1 (en) 2015-10-15 2017-04-20 Dusa Pharmaceuticals, Inc. Adjustable illuminator for photodynamic therapy and diagnosis
CN107773756A (zh) * 2016-08-24 2018-03-09 杨孝军 光动力杀伤靶细胞方法
ES2859777T3 (es) * 2017-02-06 2021-10-04 3Skin As Composición de filtro solar
CN107233303A (zh) * 2017-08-07 2017-10-10 苏州纳美特生物科技有限公司 一种氨基酮戊酸冷霜及其制备方法和应用
US10357567B1 (en) 2018-01-12 2019-07-23 Dusa Pharmaceuticals, Inc. Methods for photodynamic therapy
US12570665B2 (en) 2019-06-10 2026-03-10 University Of Massachusetts Compositions comprising fullerenyl mesochlorin nano-photosensitizers with covalently bound antibiotics and their uses in combination therapy
AU2020303417B2 (en) * 2019-06-25 2025-08-28 Sun Pharmaceutical Industries, Inc. Methods for reducing pain during photodynamic therapy of actinic keratosis
CN111135474A (zh) * 2020-01-19 2020-05-12 上海市皮肤病医院 一种光动力仪器及使用方法和光敏剂处理方法
FR3109086B1 (fr) 2020-04-14 2025-10-24 Ifremer utilisation d’un extrait polaire de Skeletonema dans une thérapie photodynamique
ES2956376A1 (es) * 2022-05-13 2023-12-20 Espada Regalado Jesus Uso de un procedimiento de transferencia fotonica secuencial para fomentar la fotoproteccion y regeneracion cutanea
CN121463945A (zh) 2023-07-07 2026-02-03 费尔曼塔格公司 红藻生物质提取物及其用于消除皮肤缺陷的化妆品用途

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US5234940A (en) 1989-07-28 1993-08-10 Queen's University Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof
DE122006000051I1 (de) 1995-03-10 2007-01-04 Photocure Asa Ester der 5-Aminolevulins{ure als Mittel zur Photosensibillisierung in der Chemotherapie
US6663659B2 (en) * 2000-01-13 2003-12-16 Mcdaniel David H. Method and apparatus for the photomodulation of living cells
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EP1755676B1 (en) * 2004-06-09 2012-11-28 QLT, Inc. Photodynamic therapy for the treatment of hyperactive sebaceous gland disorders using topically applied verteporfin and/or lemuteporfin
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KR20090001013A (ko) 2007-06-29 2009-01-08 주식회사 웰스킨 인돌-3-알킬카복실산을 함유하는 여드름 치료제 및 피지분비 억제제, 및 이를 포함하는 광역학적 치료용 키트
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US11730814B2 (en) 2023-08-22
US20210138068A1 (en) 2021-05-13
US20200323983A1 (en) 2020-10-15
BR112016014077A2 (pt) 2017-08-08
CN105899202A (zh) 2016-08-24
JP2017505292A (ja) 2017-02-16
JP2021183632A (ja) 2021-12-02
US20160346392A1 (en) 2016-12-01
EP3082788B1 (en) 2018-11-21
US20190209686A1 (en) 2019-07-11
EP3082787B1 (en) 2020-11-25
JP6933685B2 (ja) 2021-09-08
JP6639398B2 (ja) 2020-02-05
EP3082787A1 (en) 2016-10-26
JP2017503785A (ja) 2017-02-02
WO2015092052A1 (en) 2015-06-25
WO2015091037A1 (en) 2015-06-25
US20160287701A1 (en) 2016-10-06
JP2019194213A (ja) 2019-11-07
BR112016014081A2 (pt) 2017-08-08
US10953094B2 (en) 2021-03-23
CN105899201A (zh) 2016-08-24
JP2020002160A (ja) 2020-01-09
CN105916498A (zh) 2016-08-31
ES2709446T3 (es) 2019-04-16
EP3799868A1 (en) 2021-04-07
WO2015092060A1 (en) 2015-06-25
US10716855B2 (en) 2020-07-21
JP2017504602A (ja) 2017-02-09
EP3082789A1 (en) 2016-10-26
BR112016014073A2 (pt) 2017-08-08
US20160339222A1 (en) 2016-11-24
EP3082788A1 (en) 2016-10-26

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