JP6585966B2 - Smoke prevention mold method - Google Patents

Description

The present invention relates to a smoke prevention mold method for suppressing the generation of mold.

Originally, in Japan, which is hot and humid, there is much damage to mold. In recent years, the number of houses with high airtightness has increased, and the damage has increased. Mold growth is not only detrimental to aesthetics but also a risk of infectious diseases, and is therefore a major hygiene problem. In particular, it is necessary to suppress the occurrence of mold because mold tends to propagate in a humid bathroom and the risk of infection is likely to increase. Until now, as countermeasures against mold in the bathroom, mainly mold that has already occurred has been treated with hypochlorous acid preparations, etc., but in recent years it has occurred before mold has occurred. Preventive measures are also being taken. In order to achieve the latter, as an organic foaming agent and antifungal agent, a smoke agent composition containing silver inorganic agent or 2-methoxycarbonyl-4-chlorotrifluoromethanesulfonanilide is smoked by heating, A method of smoking indoors is known (Patent Documents 1 to 3). The demand for such smoke agent articles is increasing because it can easily prevent mold in the entire bathroom.

Japanese Patent No. 5647815 JP 2013-249264 A Japanese Patent No. 4110618

  However, in the above smoke smoking article, an antifungal agent is essential in addition to the organic foaming agent. When blending an anti-fungal agent into an organic foaming agent, it is necessary to pay attention to the physical properties of the anti-fungal agent and to confirm the compatibility of the stability due to the blending. Therefore, there has been a demand for a method that can more easily prevent mold.

In achieving the above-mentioned problems, the present inventors use an organic foaming agent that is usually used at the place of use, and smokes the organic foaming agent to provide an excellent mold generation suppressing effect at the place of use. It was found that it can be obtained. In Patent Documents 1 to 3 shown above, azodicarbonamide (hereinafter referred to as ADCA), which is an organic foaming agent, for the purpose of volatilizing antifungal components such as silver and 2-methoxycarbonyl-4-chlorotrifluoromethanesulfonanilide. Is used). However, in these patent documents, ADCA is used to volatilize the fungicidal component and does not disclose any effect of inhibiting the mold generation of ADCA.
We were diligently developing soot preparations with antifungal effects. Surprisingly, when these organic foaming agents themselves that become soot bases were smoked, they were used in their place of use. It has been found that an antifungal effect can be obtained. Furthermore, the present inventors have found that a foaming base other than ADCA, which is a widely used foaming base other than ADCA, has an antifungal effect, and has completed the present invention.

That is, the present inventors have found that the following constitution has an excellent effect as an antifungal smoke agent.
(1) an organic foaming agent comprising at least one selected from azodicarbonamide, p, p′-oxybisbenzenesulfonylhydrazide, and hydrazodicarbonamide, an antifungal component other than the organic foaming agent, And a smoke- proof mold method using a smoke-containing composition containing no propylene glycol , wherein the organic foaming agent is heated and reacted, and the generated smoke is used as a mold- proofing ingredient to suppress the generation of mold. Smoke-proof mold method.
(2) The smoke-proofing mold method according to (1), wherein the organic foaming agent is used in an amount of 200 mg / m ³ or more per application space.
(3) The smoke prevention mold method according to (1) or (2), wherein the smoke additive composition further contains a foaming aid .
(4) The smoke- proof mold method according to (3) , wherein the blending amount of the foaming aid is 0.1 to 60% by mass with respect to the total mass of the smoke smoke composition .
(5) The smoke prevention mold method according to any one of (1) to (4), wherein the smoke agent composition is in the form of an incense stick .
(6) The smoke-proof mold method according to (5) , wherein a cellulose-based water-soluble polymer is blended in the smoke composition.
(7) the cellulose-based water-soluble polymer, carboxymethyl cellulose and, Ibushikemuribo mold method according to Ru der least one selected from hydroxypropylmethylcellulose (6).

In the mold prevention method of the present invention, the organic foaming agent alone has the effect of suppressing the generation of mold and does not require the addition of the mold prevention component. Therefore, there is no need for confirmation of stability and the like in the blending with the antifungal component. In addition, when the fungicide component is used, the fungicide component is volatilized together with the organic foaming agent, so that there is a risk of inhaling them. Since the inhalation smoke and smoke method of the present invention can reduce such inhalation risk, the risk of side effects can be reduced. In addition, when producing a smoke agent, a production process for mixing an antifungal agent is not required, so that the production becomes simple and can be produced at low cost.
Moreover, smoke time can be adjusted by making the smoke agent composition used for the present smoke prevention mold method into an incense stick form. Moreover, the coloring degree in the place after the smoke spreads at the time of soot can be reduced.

It is a schematic diagram of the glove box of the volume 100L which tested. It is a schematic diagram of the unit bus which tested.

  In the smoke agent composition used in the smoke prevention mold method of the present invention, it is essential to use at least an organic foaming agent. Any organic foaming agent may be used as long as it generates carbon dioxide gas, nitrogen gas, or the like. Examples thereof include, but are not limited to, ADCA, OBSH, HDCA, N, N′-dinitrosopentamethylenetetramine, azobisisobutyronitrile and the like. Of these, ADCA, OBSH, and HDCA are preferred because of the high safety of the reaction product. Further, ADCA and OBSH, which are exothermic decomposition types, are more preferable from the viewpoint of ease of use, and ADCA having almost no odor during reaction is most preferable.

The organic foaming agent used in the smoke agent composition used in the smoke prevention mold method of the present invention is used to use a specific space.
Although it is assumed that the specific space is used in a room or an entrance, examples of the space where humidity is high and mold is likely to occur include places such as a bathroom and a toilet. Usually, such a space is assumed to have a volume of about ³ to 15 m ³ . For such a place, the organic foaming agent component in the smoke composition used in the smoke prevention mold method is preferably 100 mg / m ³ or more per space, and more preferably 200 mg / m. More preferably, it is ³ or more. In addition, when the usage-amount is less than what was shown, there exists a possibility that a mold prevention effect may not fully be acquired. Moreover, although there is no upper limit in particular in the usage-amount, when using many, since leakage from a use place etc. is worried, 10000 mg / m < ³ > or less is shown as an upper limit.

The smoke agent composition used in the smoke prevention mold method of the present invention may contain a foaming auxiliary agent in addition to the organic foaming agent.

  The foaming assistant as used in the field of this invention refers to what has the effect | action which lowers the exothermic temperature at the time of foaming of the component of an organic type foaming agent. Any conventionally known foaming aid can be used. Illustrative examples include, but are not limited to, zinc oxide, zinc carbonate, zinc stearate, calcium stearate, urea, melamine, guanidine, fatty acid salts, sorbitan fatty acid esters and the like. 0.1-60 mass% is mentioned with respect to the whole quantity of a soot agent composition, More preferably, the compounding quantity is selected in the range of 1-30 mass%. Moreover, a foaming adjuvant may be used individually by 1 type, and it is also possible to use 2 or more types together. If it is in the said range, reaction of a foaming agent will advance rapidly and efficient smoke will be attained.

In addition to the organic foaming agent blended in the smoke-proofing agent composition used in the soot and smoke prevention method of the present invention, it is also possible to blend an antifungal component as appropriate so as not to have an effect on the present invention. . The degree that does not exert an effect on the present invention is, for example, a degree that gives a preservative effect during storage of the smoke agent composition itself, and the antifungal effect when the smoke agent composition smokes. Even when compared with the soot composition to which an antifungal component is added, the case where it does not significantly improve is shown.
About the effectiveness of the compounded antifungal ingredient, perform a test using the soot composition containing the antifungal ingredient and the soot composition excluding the antifungal ingredient from there. It is possible to confirm by conducting a comparative test of antifungal efficacy and comparing the effect. In addition, components that enhance fungicidal efficacy, antibacterial agents, bactericides, virus inactivators, etc. may be added. Insecticides, synergists, acaricides, insecticides, insect repellents, insect repellents, etc. A soiling agent, a cleaning agent, a water repellent, a hydrophilizing agent, a fragrance, a stabilizer, an excipient and the like may be blended.
Furthermore, as insecticides, pyrethroid insecticides such as phenothrin, permethrin, ciphenothrin and resmethrin, carbamate insecticides such as methoxadiazone, organophosphorus insecticides such as fenitrothion, or silafluophene, hydroprene, etofenprox, etc. Although a compound can be illustrated, it is not limited to these.
In the case of an incense stick, examples thereof include wood powder, pesticide chrysanthemum extract powder, citrus skin powder, tea powder, coconut shell powder, charcoal powder, bare ash, talc, and the like that are used as a flame retardant for ordinary incense sticks. These flame retardants can be used alone or as a mixture of two or more.
Examples of suitable binders are tab powder, hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, starch, dextrin, hydroxypropyl starch, gelatin, polyvinyl alcohol, polyvinyl acetate, polyvinyl pyrrolidone, polyacrylic acid Sodium etc. are mentioned. Any of these flame retardants and binders can be used when they do not affect the flammability of the present smoke composition. In the case of the incense stick form, it is preferable to contain a cellulose-based water-soluble polymer, and it is more preferable to use at least one selected from carboxymethylcellulose and hydroxypropylmethylcellulose among cellulose-based water-soluble polymers. .

The dosage form and dose of the smoke composition can be appropriately selected depending on the purpose and place of use, and examples of the dosage form include granules, granules, powders, and the like. These can be prepared using known production methods.
In addition, as a method of smoking the smoke composition, a method in which a certain heat source is given to the smoke composition and foamed and evaporated (direct heating method) and a smoke composition in a container are used. Any heating method (indirect heating method) in which heat is applied from the surroundings with calcium oxide or the like and heated by the heat can be used. Among these methods, the direct heating method is convenient because the apparatus is simple and does not require time and effort.
Moreover, if it is a form which smokes for a fixed time like the incense stick represented by the mosquito coil incense as a shape of a soot agent composition, it will be easier to use and useful. The incense stick may be in the form of a normal spiral, but it has a constant cross-sectional area such as a rod, plate or cylinder, or a conical shape like an aroma incense stick. A shape may be sufficient and it is not specifically limited.

Smoke can be appropriately selected according to the purpose of use and place of use. As a place of use, it can be used in bathrooms and toilets where mold is likely to occur, in a normal living room, or in a warehouse.
What is necessary is just to use the usage-amount as a soot agent composition with respect to these places, changing a usage-amount suitably according to the magnitude | size of the space which smokes.

Next, the present invention will be described in more detail based on specific examples and test examples.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.
(Raw material)
Organic foaming agent A-1: ADCA (trade name: VINYHALL AC # R-3K, manufactured by Eiwa Kasei Kogyo Co., Ltd.)
A-2: OBSH (trade name: Neoselbon N # 1000S, manufactured by Eiwa Kasei Kogyo Co., Ltd.)
A-3: HDCA (trade name: Cell Microphone 142, manufactured by Sankyo Kasei Co., Ltd.)
Foaming aid B-1: Zinc oxide (manufactured by Sakai Chemical Industry Co., Ltd.)
B-2: Sorbitan oleate (trade name: BROWNON P-80, manufactured by Aoki Oil & Fat Co., Ltd.)
Other components C-1: Anti-caking agent: Hydrous silicon dioxide (trade name: Carplex, manufactured by GSL. Japan Ltd.)
D-1: Fragrance E-1: Tab powder E-2: α-starch E-3: Carboxymethylcellulose

(Evaluation methods)
<< Inhibition of mold generation >>
The test was conducted in a glove box having a volume of about 100 L as shown in FIG. Dispense 5 mL of potato dechiolose agar medium into a sterile petri dish (Ф 5.5 cm), solidify, and then apply 20 μL of mold dispersion of Cladosporium cladosporioides. Installed at the top. At this time, the lid of the petri dish was opened and installed so that the bottom of the petri dish was in contact with the ceiling. A hot plate was installed at the center of the floor of the glove box. An aluminum foil was laid on the hot plate, a test agent was placed thereon, and the lid of the glove box was closed. In this state, the hot plate was turned on to heat the test drug. Immediately after the reaction of the drug, the hot plate was turned off and allowed to stand for 20 minutes. Thereafter, the lid of the glove box was opened, ventilated for 5 minutes, the petri dish was collected, and the petri dish lid was closed. The petri dish was allowed to stand at 25 ° C. for 7 days and observed for mold growth. A non-heated test drug was operated in the same manner, and the amount of mold cultivated at 25 ° C. for 7 days was used as a negative control.
<< Evaluation criteria for drug effects >>
A: Mold does not occur at all.
○: Mold generation is less than 20% of negative control.
Δ: Mold generation amount is 20% or more and less than 90% of negative control.
X: Mold generation amount is equivalent to negative control.

(Examples 1 to 15)
According to the composition shown in Table 1, each component was mixed in a mortar to obtain a smoke agent of Examples 2-9. For Examples 1 and 10 to 13, the described organic foaming agent was used as it was as a smoke agent. Each of the total mass was weighed and tested. The test results are shown in Table 1.

As shown in the results, in Examples 1 to 15, the mold generation amount was less than 20% of the negative control.

(Comparative Example 1)
Regarding Comparative Example 1, sodium hydrogen carbonate (manufactured by Wako Pure Chemical Industries, Ltd.), which is an inorganic foaming agent, was used as it was as a smoke agent, and the described mass was measured and used. The results are shown in Table 2.
As a result, in Comparative Example 1, the amount of mold generation was equivalent to that of the negative control.

<< Inhibition of mold generation in semi-field tests >>
The test was performed using a unit bath having a volume of about 3.6 m ³ as shown in FIG. Dispense 5 mL of potato dechiolose agar medium into a sterile petri dish (Ф 5.5 cm), solidify, apply 20 μL of Cladosporium cladosporioides mold dispersion, and extend well with a conical rod. Installed in the center of the ceiling. At this time, the lid of the petri dish was opened and installed so that the bottom of the petri dish was in contact with the ceiling.
As a smoke agent composition of the present invention, as described in Example 14, 5.0 g of a mixture obtained by mixing 95% ADCA, 3% zinc oxide and 2% complex with a mortar was taken, and a polyethylene laminated film The test drug was encapsulated inside.
This test drug was placed in the center of the unit bath floor, and the smoke of the test drug was started with an ignition tool. Immediately after the start of smoking, he went out of the unit bath, closed the door, and maintained this state for 60 minutes. Thereafter, the ventilation fan of the unit bath was operated and ventilated for 20 minutes. The petri dish installed in the unit bath was collected and the lid was closed. The petri dish was allowed to stand at 25 ° C. for 7 days and observed for mold growth. The amount of mold generated when cultured at 25 ° C. for 7 days without smoke was used as a negative control.

(Examples 14 to 16)
In the same manner as in Example 14, according to the composition shown in Table 3, the components were mixed to produce the smoke agents of Examples 15 and 16, and the tests were performed. The results are shown in Table 3.

As shown in the results, no mold was generated in Examples 14 to 16.

<< Inhibition of mold generation in semi-field tests >>
The test was performed using a unit bath having a volume of about 3.6 m ³ as shown in FIG. Dispense and solidify 5 mL of potato dechiolose agar medium in a sterile petri dish (Ф 5.5 cm), apply 20 μL of mold suspension of Cladosporium cladosporioides, and extend well with a conical bar. Installed in the department. At this time, the lid of the petri dish was opened and installed so that the bottom of the petri dish was in contact with the ceiling.
As described in Example 17, as an incense-shaped smoke agent composition of the present invention, water was added to one obtained by mixing ADCA 84%, zinc oxide 12% and carboxymethylcellulose 4% in a mortar. And kneaded into a rod shape with a diameter of about 1 cm. This was dried at 150 ° C. for 2 hours and 10 g cut out was used as a test drug.
The test chemical was ignited with a lighter and installed in the center of the unit bath floor to start soot. Immediately after the start of smoking, he went out of the unit bath, closed the door, and maintained this state for 60 minutes. Thereafter, the ventilation fan of the unit bath was operated and ventilated for 20 minutes. The petri dish installed in the unit bath was collected and the lid was closed. The petri dish was allowed to stand at 25 ° C. for 7 days and observed for mold growth. The amount of mold generated when cultured at 25 ° C. for 7 days without smoke was used as a negative control.

(Examples 17 to 18)
In the same manner as in Example 17, each component was mixed according to the composition shown in Table 4 to prepare the soot medicine of Example 18, and the test was performed. The results are shown in Table 4.

Both Examples 17 and 18 showed a high effect. In particular, Example 17 containing carboxymethylcellulose was more effective.

The fungicide of the present invention is not limited to use in the bathroom, but may be effectively used in places where mold or the like is likely to occur or where infections are likely to occur.

Claims (7)

An organic foaming agent comprising at least one selected from azodicarbonamide, p, p'-oxybisbenzenesulfonylhydrazide, and hydrazodicarbonamide, an antifungal component other than the organic foaming agent, and propylene glycol A smoke prevention mold method using a smoke agent composition not containing
A smoke prevention mold method that suppresses the generation of mold using smoke generated when the organic foaming agent is heated and reacted as a mold prevention component . The smoke-proof mold method according to claim 1, wherein the organic foaming agent is used in an amount of 200 mg / m ³ or more per application space. The smoke prevention mold method according to claim 1 or 2, wherein a foaming aid is blended in the smoke composition. The smoke- proof mold method according to claim 3, wherein the blending amount of the foaming aid is 0.1 to 60% by mass with respect to the total mass of the smoke agent composition . The smoke-proof mold method according to any one of claims 1 to 4, wherein the smoke-moist composition is formed into an incense stick shape. 6. The smoke- proof mold method according to claim 5, wherein a cellulosic water-soluble polymer is blended in the smoke composition . The smoke-proof mold method according to claim 6, wherein the cellulose-based water-soluble polymer is at least one selected from carboxymethylcellulose and hydroxypropylmethylcellulose .