JP6570699B2 - Tablet packaging equipment - Google Patents

Description

  The present invention relates to a PTP sheet packaging apparatus for tablets, particularly high pharmacological tablets.

  A PTP (press-through package) sheet is a sheet-like container having a plurality of pockets formed of a thermoplastic resin film or an aluminum film. Each pocket contains a tablet, and an opening of these pockets is formed of an aluminum foil sheet. It is closed with a lid material. Such a PTP sheet is manufactured by a tablet packaging device (blister packaging device).

  The tablet packaging apparatus 100 includes a pocket forming mechanism 140 that thermally forms a pocket for storing tablets in a long container film drawn from a film roll attached to the apparatus main body 110, and a tablet filling mechanism that fills the pocket with a tablet. 160, a sticking mechanism 170 for sticking an aluminum foil cover film to a container film to close the pocket, a slit forming mechanism for forming a shallow slit in the container film, and a punching mechanism for punching the container film in units of PTP sheets ing.

  Among these, the tablet filling mechanism 160 stores a large amount of tablets, receives a tablet from a hopper that supplies the tablets as appropriate, a linear feeder that linearly conveys the tablets supplied from the hopper, and a linear feeder. A bowl feeder for supplying tablets in a row to a plurality of coil chutes connected to the outlet, and a filling device for filling the tablets sent through the coil chutes into the pockets formed in the container film one by one It consists of The tablet filling mechanism 160 is installed immediately above a pocket forming mechanism 140 composed of a large number of precision parts such as a servo motor, a heater, and a ball screw mechanism.

  The linear feeder or bowl feeder of the tablet filling mechanism 160 continuously vibrates a large amount of exposed tablets using vibration, so that the tablets come into contact with each other during transportation, or the tablets of the tablet filling mechanism 160 A part of the tablet is scraped and powdered because it comes into contact with the component parts, and adheres to the surface of each part of the tablet filling mechanism 160 and the periphery including the fine gap and rail part. In particular, since the rail portion installed below the tablet filling mechanism 160 supports the container film from below from the tablet filling mechanism 160 to the sticking mechanism, a large amount of the powder of the dropped tablet adheres.

  The sticking mechanism 170 is provided with a bottom seal roller and a seal roller for thermocompression bonding of a cover film drawn from an aluminum foil roll to a container film containing tablets. It pops out at the time of thermocompression bonding, gets caught between the bottom seal roller and the seal roller and is crushed, and fragments and powder may be scattered around.

  On the other hand, tablets are coated with sugar-coated tablets such as sugar-coated tablets, and in recent years, products with high pharmacological activity (highly pharmacologically active drugs) such as anticancer agents have been increasingly used for PTP packaging. ing. In the case of such highly pharmacologically active pharmaceuticals, the amount to be produced may be small, and there is an increasing tendency to produce a variety of products in small quantities, and a single packaging device handles a variety of products. In addition, non-sugar-coated tablets that are easily broken in the mouth and are easy to drink, and are therefore easily scraped to produce powder due to contact are also handled. When filling these tablets one by one into the pockets formed on the container film, the tablets come into contact with each other, contact with the component parts, or are bitten and crushed, generating a considerable amount of powder. Adhere to the surroundings as described above.

  In such a situation, when the product is switched, the tablet dust or residual powder of the previous lot causes a problem in quality control called cross contamination that adheres to the drug of the subsequent lot. It is necessary to reliably clean each part of the tablet filling mechanism 160 and the sticking mechanism 170 and the periphery thereof.

  However, the tablet filling mechanism is installed at a high position of the tablet packaging device, and has a structure in which many devices are complicated as described above, and the sticking mechanism is located in the central part of the device main body, and has a minute gap. A cleaning operation that reliably removes even the powder that has entered it takes a long time such as half a day or a day or more.

  Moreover, this cleaning and product switching work has problems in occupational safety and health from the viewpoint of worker safety at the production site. In particular, in the case of highly pharmacologically active pharmaceuticals, there are many substances that are harmful to health. There is. Therefore, in order to completely remove the exfoliated powder in the above work, it is not necessary to simply clean, but it has become necessary to wash the powder adhering part including the tablet filling mechanism. However, the tablet filling mechanism is a precision component. Since the container film must be drawn and moved throughout the main body of the device, the periphery of the tablet filling mechanism and the precision equipment of the main body of the device No matter how the tablet filling mechanism is isolated, it is difficult to completely isolate the parts related to tablet filling from the equipment of the main body composed of other precision instruments. There is a risk of damage to these precision instruments, and it has been impossible to employ water washing in the conventional apparatus body structure. Further, as described above, the sticking mechanism is located at the central portion of the apparatus main body and is adjacent to the pocket forming mechanism, and there are many precision devices in the vicinity thereof. Therefore, Patent Document 1 has been proposed as a solution to the problem associated with the former.

JP 2007-8478 A

  The tablet packaging device 100 described in Patent Document 1 unitizes the tablet filling mechanism 160 so that it can be attached to and detached from the device main body 110 having other mechanism parts such as a pocket forming mechanism 140. The unitized tablet filling mechanism 160 is removed from the apparatus main body 110, and another filling unit (tablet filling mechanism) is attached so that the removed tablet filling mechanism 160 can be carefully cleaned in an isolated cleaning space.

  However, since the tablet filling mechanism 160 occupies a large part of the cost of the entire tablet packaging apparatus 100, separately preparing the replacement tablet filling mechanism 160 greatly increases the cost of the entire apparatus. In addition, the unitized tablet filling mechanism 160 has subtle machine differences due to parts processing and assembly, and it is not sufficient to simply replace them. In Patent Document 1, it is pointed out that fine adjustment is required at the time of replacement. Moreover, the latter problem is untouched.

  The present invention has been made in order to solve the above-described problems, and the object thereof is not to increase the cost by devising the housing structure of the sticking mechanism, and conventionally, this device is impossible. It is an object of the present invention to provide a tablet packaging apparatus that can incorporate water washing and washing without causing any damage to precision equipment installed in the apparatus main body.

The tablet packaging apparatus 10 according to claim 1 forms a pocket 1b for storing a tablet in a long container film 1a and feeds it to the side of the tablet filling mechanism 17, and the tablet filling mechanism 17 stores the tablet 1d in the pocket 1b. The container body 1a is taken up and the cover film 3a is attached to the container film 1a. After that, the apparatus body 11 is cut into a predetermined shape and sent out as a PTP sheet 1.
A watertight cleaning box 12 which is fixed adjacent to the apparatus main body 11 and has a tablet filling mechanism 17 incorporated therein;
A cleaning housing 70 is built in the apparatus main body 11, and an adhesive mechanism 19 for attaching the cover film 3a to the container film 1a in which the tablets 1d are stored in the pockets 1b. Is stored,
The cleaning housing 70 has an inlet 70d into which the container film 1a filled with the tablet 1d is drawn, a drawing port 70f into which the cover film 3a is drawn, and a cover film on the opening side of the container film 1a filled with the tablet 1d. In the tablet packaging device provided with an outlet 70e through which the container film 5 to which 3a is attached is drawn out ,
A washing mechanism 71 is provided in the washing casing 70, and the inlet / outlet ports 70d and 70e and the inlet port 70f are watertight sealing covers that close the inlet / outlet ports 70d and 70e and the inlet port 70f during cleaning. 74d, 74e, and 74f are provided, and the wall surface of the cleaning housing 70 is equipped with a glove 72 for operating the water washing mechanism 71 from the outside .

Thereby, even if the tablet 1d is bitten at the time of sealing, the drug dust generated from the tablet 1d is confined in the cleaning housing 70 and does not go outside (inside the apparatus main body 11). Further, for example, when the cleaning housing 70 is cleaned with a cleaning tool (or spray gun 78) such as a spray spray in the cleaning housing 70, the medicine-contaminated water is not scattered outside the cleaning housing 70. .

Claim 2 is the tablet packaging apparatus 10 according to claim 1, wherein the “adhesion mechanism 19 is pressed against the bottom seal roller 20 for conveying the container film 1 a containing the tablet 1 d and the bottom seal roller 20 to be supplied. And a sealing roller 21 that thermocompression-bonds the cover film 3a to the opening side surface of the container film 1a ".

Claim 3 is the tablet packaging apparatus 10 according to claim 1 or 2 , wherein at least the cover film 3a is thermocompression-bonded to the opening side surface of the container film 1a, the pressure P2 in the cleaning housing 70 is within the apparatus main body 11. It is characterized by being held at a negative pressure compared to the pressure P1. The pressure P2 in the cleaning housing 70 may be the same as the pressure in the cleaning box 12, or may be different as long as the above conditions are satisfied.

A fourth aspect of the present invention is the tablet packaging apparatus 10 according to any one of the first to third aspects, wherein at least the cover film 3a flows from the apparatus main body 11 to the cleaning casing 70 during thermocompression bonding to the opening side of the container film 1a. It is characterized in that dry air is supplied to the inlet / outlet ports 70d and 70e and the inlet port 70f.

  According to the present invention, the tablet filling mechanism 17 to be cleaned, its peripheral devices and its members are housed in the watertight cleaning box 12, and the pocket 1b is formed in the container film 1a, which is composed of precision parts in particular. Of the container film 1a that is completely separated and independent from the upper part or side of the apparatus main body 11 containing the pocket forming mechanism 14 for performing the operation, and that connects the apparatus main body 11 and the cleaning box 12. The passage 28 is provided with a watertight sealing cover 45 that closes these during cleaning, so that when the product is switched, the passage 28 is independent of the apparatus main body 11 in which precision equipment that is sensitive to water is installed. Then, only the inside of the cleaning box 12 loaded with drug dust can be washed with the water washing mechanism 40.

  On the other hand, since the sticking mechanism 19 and its peripheral devices and members are housed in the cleaning housing 70 and isolated from the surroundings in the apparatus main body 11, they are temporarily housed in the pocket 1b of the container film 1a at the time of sealing. Even if the tablet 1d that has been held is bitten into the adhering mechanism 19 by some kind of elasticity, the drug dust remains in the cleaning housing 70 and does not scatter to the outside (inside the apparatus main body 11). It is. If the water-tight sealing covers 74d to 74f that close the outlet / inlet ports 70d and 70e and the inlet 70f of the cleaning housing 70 are closed at the time of cleaning, the inside of the cleaning housing 70 is provided. Can be washed with water if necessary.

  At the time of washing with water, the washing box 12 is equipped not only with a spray nozzle 42 for watering included in the washing mechanism 40 but also with a spray gun 43 that can be operated by putting a hand into the glove 48b. Therefore, it is possible to reliably remove the tablet dust that has entered the fine gaps of the equipment constituting the tablet filling mechanism 17 and the sticking mechanism 19. The tablet dust removed by washing flows into the washing sewage treatment unit 44 together with the washing water, and is taken out as it is or stored in the storage tank 44b without touching the operator. If the structure of the tablet filling mechanism 17 (for example, precision bearings) is not satisfactory for waterproofing after washing with water, for example, the tablet filling mechanism 17 or the sticking mechanism 19 is covered with a vinyl bag inside. The inside of the washing box 12 excluding the tablet filling mechanism 17 is washed with water and dried, and then the tablet filling mechanism 17 and the sticking mechanism 19 are sealed with a vinyl bag for washing. You may make it take out from the box 12 and the housing | casing 70 for washing | cleaning, and you may make it wash | clean in another place.

  Even if the tablet 1d is bitten as described above, the amount of drug dust generated in the cleaning housing 70 is much smaller than that of the tablet filling mechanism 17, so that each mouth of the cleaning housing 70 is used for cleaning. 70d, 70e, and 70f are sealed in a watertight manner with the sealing covers 74d, 74e, and 74f, and then a hand is put in the glove 72 and the sprayer 78 (or the spray gun 78) that is the water washing mechanism 71 is operated, so that the chemical dust is applied to the necessary place. Blow a mist that can be wiped off. As a result, it is possible to cope with the generation of drug dust in the cleaning housing 70.

  In addition, the pressure P2 in the cleaning box 12 and the cleaning housing 70 is maintained at a negative pressure compared to the pressure P0 of the outside air and the pressure P1 in the apparatus main body 11 at least during the filling operation, and further, at least the tablet 1d. Since the dry air is supplied from the apparatus main body 11 to the cleaning box 12 and the cleaning casing 70 during the filling operation, the air in the cleaning box 12 and the cleaning casing 70 mixed with tablet dust is used as the apparatus main body. The packaging work can be safely proceeded without leaking into or outside of 11.

It is a schematic structure front view which shows the tablet packaging apparatus concerning this invention. It is the schematic block diagram seen from the front of the box for washing | cleaning of FIG. FIG. 2 is a front view of a schematic configuration of the cleaning box in FIG. 1. It is a front view of the pocket formation mechanism and intermittent drawer mechanism of FIG. It is a schematic perspective view of the housing | casing for washing | cleaning of FIG. FIG. 6 is a schematic sectional front view showing the inside of FIG. 5. FIG. 7 is a cross-sectional view of the cleaning housing of FIG. 6 taken along the line XX. It is a figure of the state which replace | exchanges the tablet filling mechanism of the conventional tablet packaging apparatus.

  Hereinafter, an embodiment of the present invention will be described with reference to the drawings. As shown in FIG. 1, the tablet packaging apparatus 10 includes an apparatus main body 11 having a cleaning housing 70 provided therein as necessary, and a cleaning box 12 adjacent to the apparatus main body 11 and fixed to the apparatus main body 11. As will be described later, the apparatus main body 11 has a box shape for storing apparatuses other than the tablet filling mechanism 17 stored in the cleaning box 12 and its peripheral equipment.

  On the most upstream side of the apparatus main body 11 (lower right position in the figure), a roll holding unit 13 is installed, and a strip-shaped container film 1a is wound into a roll shape, and the film roll 2 is subjected to a certain tension. It can be pulled out intermittently.

  On the left side of the lower part of the apparatus main body 11 in the drawing, a heating device 15 and a pocket forming device 16 constituting the pocket forming mechanism 14 are arranged in parallel along the conveyance path of the container film 1a downstream of the roll holding unit 13. . The heating device 15 is provided with hot plates 15a and 15b for selectively heating the pocket forming portions on the upper and lower sides of the container film 1a which is intermittently conveyed, and a heater (not shown) is incorporated therein. Further, as a mechanism unit, a cam mechanism (not shown) for moving the heating plates 15a and 15b up and down to sandwich and separate the container film 1a, a ball screw mechanism (not shown) for operating the cam mechanism, and a ball screw mechanism Servo motors 15c and 15d for rotating the motor, a linear guide mechanism (not shown) for guiding a cam member (not shown) that reciprocates in accordance with the forward / reverse rotation of the ball screw mechanism, and a bearing (not shown) for supporting them. ) And other precision parts are incorporated.

  The pocket forming device 16 following the heating device 15 includes a female die 16b in which the shape of the pocket 1b is recessed, and a cam mechanism for clamping and separating the corresponding male die 16a and female / male die 16a, 16b. (Not shown), precision parts such as a ball screw mechanism (not shown) for operating the cam mechanism, servo motors 16c and 16d, a linear guide mechanism (not shown), and a bearing (not shown) for supporting them. Is incorporated.

  An intermittent drawer mechanism 60 is provided on the downstream side of the pocket forming mechanism 14 to pull out the container film 1a formed with the pockets 1b by intermittent feed, and further moves vertically while applying a constant tension corresponding to the intermittent feed. The dancer roll 16e to perform is provided, and the buffer function is given to the conveyance of the container film 1a being intermittently conveyed. When the dancer roll 16e is exceeded, the container film 1a is turned from the vertical direction to the horizontal direction by the fixed roller 16f, and sent to the passage port 28 connecting the apparatus main body 11 and the cleaning box 12 (FIG. 1). The passage opening 28 is formed in the boundary wall 12a between the apparatus main body 11 and the cleaning box 12, and the apparatus main body 11 and the cleaning box 12 are communicated with each other, and the container film 1a passes therethrough. Although the boundary wall 12a is configured by a single plate material in the drawing, it may be provided in each of the apparatus main body 11 and the cleaning box 12, and in this case, an opening is provided in the same place, These become the passage openings 28. Here, in the normal state, since the inside of the apparatus main body 11 other than the cleaning casing 70 is not contaminated with the drug dust, the front cover 11b of the apparatus main body 11 can be opened to operate the inside. The glove port having 48a is not necessarily required for the apparatus main body 11. However, when more safety is required for the operator, one or more glove ports in which one or more glove 48a is installed at an appropriate position on the front surface of the apparatus main body 11. May be provided.

  In the cleaning box 12, a brake roller 17f is disposed at the same height corresponding to the fixed roller 16f. The brake roller 17f applies a tension to the container film 1a, changes the direction of the container film 1a in the reverse direction, and feeds it onto the rail portion 17g arranged below the tablet filling mechanism 17. The rail portion 17g is arranged horizontally, and a groove (not shown) is formed in the upper surface of the rail portion 17g in the feeding direction of the container film 1a so as to match the pocket 1b. Go through the inside. During this time, the tablets 1d are sequentially supplied from the tablet filling mechanism 17 to the pockets 1b. The cleaning box 12 will be described later.

  When the tablets 1 d are sequentially supplied from the tablet filling mechanism 17 to the pocket 1 b, the container film 1 a is drawn into the apparatus main body 11 from the passage port 28 that connects the cleaning box 12 and the apparatus main body 11. On the apparatus main body 11 side, a guide plate 18g for mounting and guiding the container film 1a is mounted flush with the rail portion 17g, and the container pulled out to the apparatus main body 11 side by the tablet filling status confirmation device 18 is attached. It is confirmed by image processing whether the tablet 1d is securely stored in the pocket 1b of the film 1a, whether the tablet 1d is chipped, whether there is an appearance abnormality such as a crack, and whether foreign matter is mixed. The tablet filling status confirmation device 18 is installed on the guide plate 18g just before the sticking mechanism 19 outside the cleaning housing 70.

  Following this, an adhesive mechanism 19 is provided for adhering (thermocompression) an aluminum foil cover film 3a drawn from the aluminum foil roll 3 to the container film 1a to close the pocket 1b. The sticking mechanism 19 includes a bottom seal roller 20 that is fed while the pocket 1b of the container film 1a containing the tablet 1d being transported is fitted therein, and a heater (not shown), and rotates to the bottom seal roller 20. While pressing the bottom seal roller 20 and thermocompression bonding the cover film 3a to the container film 1a, the direction changing rollers 22a and 22b for changing the direction of the container film 5 to which the cover film 3a has been thermocompression bonded and The cover roller 24 is configured to guide the cover film 3 a in the direction of the seal roller 21, and these are accommodated in the cleaning housing 70. It is to be noted that the cleaning case 70 detects the behavior of the sealing roller 21 via the L-shaped lever 21a provided on the sealing roller 21 (the sealing roller 21 is flipped up and deviated from the detection range when it is engaged). An intrusion detector 27 is also housed. In addition, the aluminum foil roll support part 4 is installed in the upper right of the apparatus main body 11 in the figure, and holds the aluminum foil roll 3 so that it can be pulled out under a certain tension.

  The cleaning housing 70 is composed of a rectangular housing body 70a having a front opening and a housing door 76 provided in the front opening. The rear surface of the housing body 70a is attached to the mounting plate 11a of the apparatus body 11. ing. The mechanism part schematically shown by the phantom line of the sticking mechanism 19 is located on the back side of the mounting plate 11a. The cleaning housing 70 itself is built in the apparatus main body 11, but the housing door 76 may be inside the front cover 11 b of the apparatus main body 11 as shown in FIG. However, the front cover 11b may be provided with an opening from which the housing door 76 is exposed to the outside. In the present specification, the former example will be described.

  The housing body 70a has an inlet 70d through which the container film 1a in a state where the tablet 1d is stored in the pocket 1b, a drawing port 70f into which the cover film 3a is taken, and the cover film 3a on the pocket opening surface side of the container film 1a. And an outlet 70e through which the container film 5 sealed is passed. The inlet 70d is formed on the tablet filling status confirmation device 18 side (the left side surface in FIG. 6) of the housing body 70a. A sealing cover 74d is slidably provided above the inlet 70d, and is fixed to the housing body 70a with a set screw 75d. Similarly, an outlet 70e is formed on the side of the slit forming mechanism 25 of the housing body 70a (the right side surface in FIG. 6), and the container film 5 to which the cover film 3a has been thermocompression bonded is drawn out. A sealing cover 74e is slidably provided above the outlet 70e, and is fastened to the housing body 70a with a set screw 75e. Further, a drawing port 70f is formed on the upper surface of the housing body 70a, and the cover film 3a is drawn. A sealing cover 74f is slidably provided on the side of the inlet 70f, and is fixed to the housing body 70a with a set screw 75f. The fixing of the sealing covers 74d to 74f by the set screws 75d to 75f is an example of a fixing method of the sealing cover, and the fixing method is not limited to this.

  A suction box 70b is further provided on the tablet filling status confirmation device 18 side (the left side surface in FIG. 6) of the housing main body 70a, and the high-performance filter 70g is provided therein. A decompression pipe 47a is connected to the suction box 70b, and the pressure in the cleaning housing 70 is P2, which is always kept at a negative pressure from the inside of the apparatus main body 11. At least during the sealing operation, dry air is constantly supplied into the cleaning housing 70 from the respective ports 70d, 70e, and 70f. In addition, two glove ports are provided in the housing door 76, and a glove 72 for operating or cleaning the equipment installed in the cleaning housing 70 from the outside when the cleaning housing 70 is closed. After cleaning, the housing door 76 can be opened to perform internal operations. A housing box 70c opened inside the main body is installed on the slit forming mechanism 25 side (the right side surface in FIG. 6) of the housing main body 70a and equipped with a sprayer (or spray gun 78). (If the equipment in the cleaning housing 70 is waterproof, a spray gun 78 is used. If the equipment is not waterproof enough, mist is sprayed only on necessary parts. A bottom sprayer 70a1 of the casing body 70a has a very shallow inclined mortar shape, a drain outlet is provided at the lowest part, and a sewage treatment pipe 77 is installed. . In this case, the mist sprayer (or spray gun 78), the bottom portion 70a1 and the sewage treatment pipe 77 constitute the cleaning housing side water washing mechanism 71.

  Downstream of the sticking mechanism 19, a slit forming mechanism 25 for forming a shallow slit groove between the pockets 1b of the container film 5 to which the cover film 3a is attached, and then the container film 5 to which the cover film 3a is attached is PTP. A punching mechanism 26 for punching in units of sheets is installed. An appearance inspection device 23 for detecting an abnormality such as a tablet 1d from the pocket 1b side is provided downstream of the sticking mechanism 19, and when a defective product is determined by appearance inspection, a defective sheet (not shown) is shown. A defective product signal is sent to the discharge mechanism, and the defective PTP sheet 31 is discharged separately by a defective sheet discharge mechanism (not shown), transferred to the defective product hopper 32, and determined as a good product. Is taken out of the machine, transferred by a conveyor 33, and stored in a non-defective hopper 34. (Alternatively, although not shown, a predetermined number of non-defective PTP sheets 1 are stacked and bound by a band.)

  The cleaning box 12 is a box-shaped box having a rectangular parallelepiped shape in which a transparent plate is fitted into a frame. An opening / closing door 49 is provided on the front surface of the cleaning box 12, and the opening / closing door 49 and the sealing cover 45 are provided during cleaning. In the closed state, the watertight state is kept completely, and after cleaning, it can be opened for internal operation. The opening / closing door 49 is provided with four glove ports, and a glove 48b is provided. Similarly, a glove port (not shown) is provided on the side of the cleaning box 12, a glove (not shown) is installed, and a bagout box 29 and a pass box 30 are also installed.

  The bag-out box 29 is a hollow cylindrical body that is installed so as to protrude from the side surface of the cleaning box 12 so as to surround the periphery of the through hole formed in the side surface of the cleaning box 12. A resin film cylinder 29a that is gathered and compressed is inserted into the outer periphery of the bag-out box 29, the insertion end is fixed to the outer peripheral surface of the bag-out box 29, and the other end is tied with a string. The box 29 itself is closed.

  The pass box 30 is a box for taking in and out necessary tools and other parts from the side of the cleaning box 12 when the tablet filling mechanism 17 is repaired or attached, and an opening / closing door (not shown) is provided at the open end. Is installed and kept closed at all times.

  In addition, the cleaning box 12 is connected to a decompression device 47 that sucks air inside the cleaning box 12 and keeps the negative pressure with respect to the outside air and the internal pressure of the apparatus main body 11 at all times. A filter box with a built-in high-performance filter and other devices to be described later are incorporated. Further, when the tablets are filled, dehumidified air flows from the apparatus main body 11 to the cleaning box 12 side through the passage port 28 by the decompression device 47. As a result, the internal pressure P2 of the cleaning box 12 is the lowest, the internal pressure P1 of the apparatus main body 11 is next, and the highest is the external air P0. That is, P0> P1> P2 as in the case 70 for cleaning. As a result, when the tablets are filled, the contaminated air in the cleaning box 12 does not easily enter the apparatus body 11 side and does not leak into the outside air at all. The cleaning box 12 is always kept dry by the dehumidified air during the filling operation.

  The tablet filling mechanism 17 accommodated in the cleaning box 12 includes a hopper 17a, a linear feeder 17b, a bowl feeder 17c, a coil chute 17h, and a filling device 17i. The tablet filling mechanism 17 is installed in the upper part of the washing box 12, and the hopper 17a is for storing the tablet 1d supplied from the outside of the apparatus so that the tablet 1d inside slides smoothly. It has become. A linear feeder 17b is installed at the outlet of the hopper 17a. Since the tablet 1d dislikes moisture, the dry air is supplied to the dry zone near the hopper 17a and the passage opening 28 on the apparatus body 11 side through the dry air supply path 50. As described above, due to the pressure difference between the cleaning box 12 and the apparatus main body 11, dry air flows to the cleaning box 12 side through the passage port 28 during tablet filling.

  The linear feeder 17b linearly moves the tablet 1d dropped on the feeder main body using vibration in the straight traveling direction, and supplies the tablet 1d by a predetermined amount to the bowl feeder 17c disposed on the front side thereof. The linear feeder 17b includes a sensor for adjusting the supply amount to the bowl feeder 17c.

  The bowl feeder 17c includes a drive unit 17d that generates vibrations in the rotational direction of a circular dish-shaped bowl member 17e installed on the upper portion and rotates the supplied tablet 1d along the circular outer wall of the bowl member 17e. . The amount of the tablet 1d stored in the bowl member 17e is detected by the action of the sensor of the linear feeder 17b. Based on the detection result, a fixed amount of the tablet 1d is supplied by the linear feeder 17b. The bowl member 17e is provided with a tablet supply port (not shown), and a coil chute 17h is attached thereto, and the tablet 1d is supplied to the coil chute 17h as the bowl member 17e vibrates in the rotational direction. .

  The coil chute 17h is formed as a hose by spirally winding a coil spring. The coil chute 17h connects the tablet supply port and the filling device 17i, and the tablet 1d passes through the inside by its own weight, and the tablet is placed in the filling device 17i. Supply 1d.

  The filling device 17i is provided immediately above the container film 1a, and sequentially fills the pockets 1b of the container film 1a with the tablet 1d supplied from the coil chute 17h by rotation of a built-in rotary drum (not shown).

  A plate-like rail portion 17g extending in the conveying direction of the container film 1a is disposed below the filling device 17i. The rail portion 17g is a conveyance guide for supporting the container film 1a and is supported from below, and a groove (not shown) is formed on the upper surface of the rail portion 17g in the conveyance direction of the container film 1a corresponding to the pocket 1b. .

  Any method may be used for closing the passage port 28 as long as moisture does not leak to the apparatus main body 11 side during cleaning. Here, the structure of the watertight sealing cover 45 is as shown in the enlarged portion of FIG. The watertight sealing cover 45 includes a grip 61, a screw shaft 62 implanted in the grip 61, a U-shaped lock member 63 through which the screw shaft 62 is inserted, and a packing 65 that is in close contact with the entire circumference of the passage port 28. The closing plate 64 covers the entire surface of the passage opening 28 and is screwed with the threaded portion of the screw shaft 62.

  And inside the washing box 12, the above-mentioned tablet filling mechanism 17, the above-mentioned flat rail portion 17 g arranged horizontally just under the tablet filling mechanism 17, and the container film 1 a drawn from the passage port 28 are changed in direction. The brake roller 17f that leads to the rail portion 17g, the spray nozzle 42 that is provided on the ceiling of the washing box 12 and sprays the tablet filling mechanism 17, and the operator passes all through the tablet filling mechanism 17 and the washing box 12. A spray gun 43 that is washed with spray water, a decompression device 47 that always keeps the inside of the cleaning box 12 at a negative pressure relative to the atmosphere and the apparatus main body 11 and also removes dust, and is disposed at the bottom of the cleaning box 12 to collect cleaning sewage An opening / closing door 49 is installed on the front surfaces of the cleaning sewage treatment unit 44 and the cleaning box 12 so as to maintain a watertight state when closed. The sides of the box 12 glove port is provided glove 48b is installed.

  Next, the operation of the present invention will be described. In the tablet packaging device 10, as described above, the tablets 1 d are supplied to the container film 1 a, and finally punched into one unit of the PTP sheet 1 by the punching mechanism 26, and only non-defective products are stored in the non-defective hopper 34. Although not shown, the unit number of sheets are stacked, banded and sent out. When packaging of one product is completed and the product is switched to the next product, cleaning inside the cleaning box 12 and the cleaning housing 70 in which drug dust is generated is performed. As described above, the cleaning casing 70 is also performed when the tablet 1d protruding from the pocket 1b is caught between the bottom seal roller 20 and the seal roller 21 and crushed.

  When switching to the next product type, the container film 1a is continuously stretched from the film roll 2 to the punching mechanism 26 through each mechanism as shown in FIG. In the cleaning box 12 in which the tablet filling mechanism 17 and its related members are installed, and in the cleaning case 70 in which the sticking mechanism 19 and its related members are installed, there are tablet dusts in the previous process. The amount of drug dust in the cleaning housing 70 is usually smaller than that in the cleaning box 12.

  Under such circumstances, first, the container film 1a is cut in the vicinity of the passage port 28 using the glove 48b on the cleaning box 12 side. The cut container film 1a is left in the cleaning box 12. Subsequently, the passage port 28 is closed from the apparatus main body 11 side. During this time, low-humidity air is sent from the apparatus main body 11 side toward the cleaning box 12 side into the passage opening 28 to prevent inflow of tablet dust from the cleaning box 12 side to the apparatus main body 11 side.

  The closing method of the passage port 28 is as follows. First, the closing plate 64 is directed from the apparatus main body 11 side to the passage opening 28 using the globe 48a on the apparatus main body 11 side, and the entire surface of the passage opening 28 is closed. Next, the glove 48b on the side of the cleaning box 12 is used to direct the leg portion of the lock member 63 from the side of the cleaning box 12 to the upper and lower sides of the passage port 28, and the screw shaft 62 inserted through the lock member 63 is connected to the closing plate 64. The edge of the passage port 28 is firmly sandwiched between the locking member 63 and the closing plate 64. The passage opening 28 is closed in a watertight manner by the packing 65.

  If the passage port 28 is closed in this manner, the spray nozzle 42 first sprays the inside of the cleaning box 12 to wet the surface of the internal devices and members so that the powder is not scattered. Subsequently, a hand is inserted into the globe 48, and the surface of the hopper 17a, the bowl member 17e of the bowl feeder 17c, the coil chute 17h, the inside / outside of the filling device 17i, and the surface of the rail portion 17g with the spray gun 43 installed inside. Of course, the minute gaps between the equipment are also cleaned. (Of course, cleaning with the spray gun 43 is possible from the beginning without spray cleaning.) The cleaning sewage in which the tablet dust is dissolved is collected in the cleaning sewage treatment unit 44 provided in the lower part of the cleaning box 12, The container 44b is stored in an external storage container (not shown) as it is through a sink 44a prepared at the bottom of the cleaning box 12. All the components of the tablet filling mechanism 17 are waterproof, but if they are not waterproof, cover the whole with a vinyl bag before washing with water and prevent the water from entering before washing. I do.

  During this time, the cut container film 1a remaining in the cleaning box 12 is also reliably cleaned, and after cleaning, the binding closed end of the resin film cylinder 29a closing the opening of the bag-out box 29 is manually cleaned. The container film 1a pushed into the box 12 for use and cut is taken into the resin film cylinder 29a. When the take-in of the cut container film 1a is completed, although not shown, the take-in part is pulled out from the bag-out box 29, and the base part of the take-in part is bundled with two places with a string, and a resin film cylinder is formed between the bundled parts. 29a is cut | disconnected and the taking-out of the cut | disconnected container film 1a is completed.

  When the cleaning is completed, dry air is blown into the cleaning box 12 to dry the inside. When the tablet filling mechanism 17 is covered with a vinyl bag, after drying, the door 49 is opened and the tablet filling mechanism 17 is taken out together with the vinyl bag. Thereafter, the tablet filling mechanism 17 is transferred to another place for cleaning, and after cleaning, it is reset in the cleaning box 12. Of course, you may reset the tablet filling mechanism 17 prepared separately. Then, the watertight sealing cover 45 of the passage opening 28 is also removed and opened, the container film 1a is transferred again, the tablet 1d of the next lot is supplied to the hopper 17a, and preparation for resuming the packaging operation is performed.

  The cleaning operation on the side of the cleaning casing 70 is lighter than the cleaning box 12 in terms of the amount of tablet dust, and the cover film 3a and the sealed container film 5 are cleaned using the glove 72 of the cleaning casing 70. Cut inside the body 70 and leave them in the cleaning housing 70. Subsequently, the sealing covers 74d, 74e, and 74f installed in the vicinity of the respective openings 70d, 70e, and 70f are slid using the globe 48a provided on the front surface of the apparatus main body 11, and then, for example, through packing or the like. The openings 70d, 70e, and 70f are closed in a watertight manner and fixed with set screws 75d, 75e, and 75f. During this time, as in the case of the cleaning box 12, low-humidity air is fed into the respective ports 70d, 70e, 70f from the apparatus main body 11 side to the inside, and the inflow of tablet dust from the cleaning housing 70 side to the apparatus main body 11 side. It is preventing.

  If each of the mouths 70d, 70e, and 70f is closed in this way, if there is a tablet 1d left in the glove 72 of the cleaning housing 70 and left by the worker, Then, the surface of the internal device and the inner surface of the cleaning housing 70 are wiped with a cleaning cloth, and when a certain amount of cleaning is performed, a sprayer (or sprayer) in the storage box 70c is used. The surface of the internal device and the inner surface of the cleaning housing 70 are cleaned with the gun 78). The cut sealed container film 5 remaining in the cleaning housing 70 (the cover film 3a and the container film 1a are partially connected to the sealed container film 5) is also reliably cleaned. The cleaning sewage in which the amount of cleaning water is large and cannot be removed by wiping and dissolved in the tablet dust is drawn to the outside through the sewage treatment pipe 77 of the shallow mortar-shaped bottom 70a1. Here, the bottom 70a1 and the sewage treatment pipe 77 constitute a cleaning sewage treatment unit 73.

  When the cleaning is completed, dry air is blown into the cleaning housing 70 to dry the inside, and after drying, the dried container film 5 is put in a pre-prepared vinyl bag or the like. Recovering without touching, and finally opening the housing door 76, take out the container film 5 and the tablet 1d together with the bag, and then attach the watertight sealing covers 74d, 74e, 74f of the respective mouths 70d, 70e, 70f. Open the container film 1a again and prepare for resuming the packaging operation. In the case 70 for washing, the above-described washing operation is performed even in the case of tablet biting in addition to product type switching. When the cleaning is completed, the container film 1a is passed over, and the packaging operation is resumed when the tablets 1d are supplied to the hopper 17a. As described above, the operator can safely change the type without touching the tablet dust as well as during the normal packaging operation.

  DESCRIPTION OF SYMBOLS 1 ... PTP sheet, 1a ... Container film, 1b ... Pocket, 1d ... Tablet, 2 ... Film roll, 3 ... Aluminum foil roll, 3a ... Cover film, 4 ... Aluminum foil roll support part, 5 ... Cover film is thermocompression-bonded Container film, 10 ... tablet packaging device, 11 ... device body, 11a ... mounting plate, 11b: front cover, 12 ... cleaning box, 12a ... boundary wall, 13 ... roll holder, 14 ... pocket forming mechanism, 15 ... Heating device, 15a, 15b ... Hot plate, 15c, 15d ... Servo motor, 16 ... Pocket molding device, 16a, 16b ... Female / male mold, 16c, 16d ... Servo motor, 16e ... Dancer roll, 16f ... Fixed roller, 17 ... Tablet filling mechanism, 17a ... Hopper, 17b ... Linear feeder, 17c ... Bowl feeder, 17d ... Drive unit, 17e ... Bow Member, 17f ... brake roller, 17g ... rail part, 17h ... coil chute, 17i ... filling device, 18 ... tablet filling status confirmation device, 18g ... guide plate, 19 ... sticking mechanism, 20 ... bottom seal roller, 21 ... seal Roller, 21a ... L-shaped lever, 22a, 22b ... Direction changing roller, 23 ... Appearance inspection device, 24 ... Cover roller, 25 ... Slit forming mechanism, 26 ... Punching mechanism, 27 ... Bucking detector, 28 ... Passing port, DESCRIPTION OF SYMBOLS 29 ... Bag out box, 29a ... Resin film cylinder, 30 ... Pass box, 31 ... Defective PTP sheet, 32 ... Defective hopper, 33 ... Conveyor, 34 ... Non-defective hopper, 40 ... Washing box side water washing mechanism, 42 ... Spray nozzle, 43 ... spray gun, 44 ... cleaning sewage treatment section, 44a ... sink, 44b ... storage tank, 45 ... dense Cover, 47 ... Pressure reducing device, 47a ... Pressure reducing pipe, 48a, 48b ... Globe, 49 ... Opening / closing door, 50 ... Dry air supply path, 60 ... Intermittent drawer mechanism, 61 ... Grip, 62 ... Screw shaft, 63 ... Lock member, 64 ... Closure plate, 65 ... Packing, 70 ... Cleaning housing, 70a ... Housing body, 70a1 ... Bottom, 70b ... Suction box, 70c ... Storage box, 70d ... Inlet, 70e ... Outlet, 70f ... Retracting port, 70g ... High-performance filter, 71 ... Washing mechanism side washing mechanism, 72 ... Glove, 73 ... Washing waste water treatment section, 74d, 74e, 74f ... Sealing cover, 75d, 75e, 75f ... Set screw, 76 ... Housing door, 77 ... Sewage treatment piping, 78 ... spray gun, 100 ... conventional tablet packaging device, 110 ... device main body, 140 ... pocket formation mechanism, 160 ... tablet filling mechanism, 170 ... sticking mechanism.

Claims (4)

A pocket for storing tablets is formed in a long container film and fed to the side of the tablet filling mechanism. The container film containing the tablets in the pocket is taken out by the tablet filling mechanism and a cover film is attached to the container film. Then, the apparatus main body cut into a predetermined shape and sent out as a PTP sheet,
It consists of a watertight cleaning box that is fixed adjacent to the device body and has a tablet filling mechanism built-in,
A container film passage through which the apparatus main body and the cleaning box communicate with each other is provided on the boundary wall between the apparatus main body and the cleaning box.
A cleaning housing is built in the apparatus main body, and in the cleaning housing, an adhesion mechanism for adhering a cover film to a container film containing a tablet in a pocket is stored.
The cleaning housing has an inlet into which a container film filled with tablets is drawn, a drawing port into which a cover film is drawn, and a container film with a cover film attached to the opening side of the container film filled with tablets. In the tablet packaging device provided with an outlet to be drawn to the outside ,
A washing mechanism is provided in the cleaning housing, and the inlet / outlet and the inlet are provided with watertight sealing covers that close the inlet / outlet and the inlet during cleaning. Is equipped with a glove for operating the water washing mechanism from the outside . The sticking mechanism is composed of a bottom seal roller that transports the container film containing the tablet, and a seal roller that is pressed against the bottom seal roller and thermocompresses the supplied cover film to the opening side surface of the container film. The tablet packaging apparatus according to claim 1 . 3. The tablet according to claim 1, wherein at least when the cover film is thermocompression bonded to the opening side surface of the container film, the pressure in the cleaning housing is maintained at a negative pressure compared to the pressure in the apparatus main body. Packaging equipment. The dry air flowing from the apparatus main body to the cleaning housing is supplied to the outlet / inlet and the inlet while at least the cover film is thermocompression bonded to the opening side of the container film. A tablet packaging apparatus according to claim 1.

Images