JP6565190B2 - Blood device cap and blood device - Google Patents

Description

  The present invention relates to a cap for a blood device through which blood is circulated, and a blood device.

  The kidneys of patients with renal failure cannot remove unnecessary metabolites in the blood. Hemodialysis is performed to remove unnecessary metabolites and the like from the blood of renal failure patients. A dialyzer or the like is known as a blood apparatus for performing hemodialysis. Moreover, activated leukocytes are contained in the blood of rheumatic patients and the like. Since activated leukocytes cause symptoms such as inflammation, leukocyte removal treatment is performed. In addition, in order to prevent viral infection when platelets are transfused, a treatment for removing leukocytes from blood components to be transfused into a platelet transfused patient is performed. A leukocyte removal filter is known as a blood device for performing leukocyte removal treatment. The main body and cap of a blood device are generally manufactured by injection molding using a thermoplastic resin as a raw material. In the injection molding, a minute groove or recess extending linearly is formed at a location where the thermoplastic resin in the mold joins. A minute groove or dent formed in such a molded product is called a weld line.

  Patent Document 1 discloses a configuration in which a gas discharge unit for discharging bubbles is provided at a place where a weld line is generated in a cylindrical container for body fluid treatment. Thereby, when the side surface of a cylindrical container is hit, it is supposed that it will become difficult to produce damage, such as a crack.

  Patent Document 2 discloses a cap member that controls the blood flow by providing a convex portion and a concave portion inside the cap member.

JP 2008/161247 A JP 2006/55205 A

  When a weld line is formed inside a cap for a blood device manufactured by injection molding, there is a possibility that blood circulated through the blood device may stay or coagulate in the weld line. For example, if blood remains in the weld line of the blood device cap, a small amount of blood remains in the weld line of the blood device cap even after all blood has flowed out of the blood device after using the blood device. There are things to do. Such residual blood is not good in appearance. A similar problem may occur even if blood coagulates in the weld line of the blood device cap.

  The present invention has been made in view of the above-described circumstances, and an object of the present invention is to provide a blood device cap and a blood device in which a weld line is not formed in a region in contact with blood.

  (1) The blood device cap according to the present invention can be attached to an opening of a cylindrical main body for a blood device, and is obtained by injection molding a thermoplastic resin. A cap for a blood device according to the present invention covers a cylindrical side portion, one opening in the axial direction of the side portion, a lid portion having a through hole along the axial direction, and the lid portion. It is provided, and an internal space is provided with the cylindrical nozzle part connected with the through-hole of the said cover part. In the attached state in which the blood device cap is attached to the opening of the main body, no weld line is formed on the inner surface of the lid portion in the blood contact region where the blood circulating in the main body can contact.

  Since the weld line is not formed in the blood contact region on the inner surface of the lid portion, the possibility that blood stays in the weld line or coagulates is reduced.

  (2) Preferably, the blood contact region is a surface that partitions the internal space of the main body in the attached state.

  (3) Preferably, the said side part has two or more gate traces in the edge part which divides the other opening of the said axial direction.

  In injection molding, since two or more gates into which the thermoplastic resin flows into the mold are provided at the edges that define the other side opening, no weld line is formed in the blood contact region. In addition, since the thermoplastic resin flows into the mold from two or more gates, the temperature of the molten thermoplastic resin (hereinafter also referred to as molten resin) is difficult to decrease in the mold, forming a weld line. It becomes difficult to be done.

  (4) Preferably, the gate marks are arranged at equal intervals in the circumferential direction on the side portion.

  Thereby, in the case of injection molding, molten resin can be inject | emitted from the gate arrange | positioned at equal intervals. The molten resin filled from each gate has the same fluidity at the junction. For this reason, the molten resin is easily mixed uniformly at the junction. Therefore, formation of a weld line is further suppressed.

  (5) Preferably, a weld line is formed on the side portion.

  (6) Preferably, the gate mark is a concave portion in which the edge portion is recessed along the axial direction.

  Since the gate mark is a recess, the blood device cap is easily removed from the mold. In addition, if the gate trace protrudes from the edge of the molded product, it may be necessary to remove the protruding gate trace to make the molded product flat. If so, such processing can be omitted.

  (7) Preferably, it is provided in the said cover part, and is further provided with the cylindrical junction part surrounding the outer side of the said nozzle part.

  If a weld line is formed in the blood device cap, it is likely to be formed in a cylindrical joint. Since the junction is not a place where the blood circulated through the blood apparatus is in direct contact, no blood stays in the weld line.

  (8) Preferably, the internal thread of the said junction part is formed with the internal thread.

  (9) Preferably, the said cover part protrudes in the taper shape to one side of the said axial direction.

  This makes it easier for the thermoplastic resin to flow from the lid portion to the nozzle portion in injection molding, so that it is difficult to form a weld line in the lid portion.

  (10) A blood apparatus according to the present invention includes the blood apparatus cap and a cylindrical main body through which blood is circulated. In the blood apparatus according to the present invention, the cap for the blood apparatus is attached to the opening of the main body.

  According to the present invention, since a weld line is not formed at least in the blood contact region on the inner wall of the lid portion of the blood device cap, blood circulating through the blood device may stay in the blood contact region of the lid portion. It is suppressed.

FIG. 1 is a diagram schematically showing a blood device 10. 2A is a perspective view of the cap 12A viewed obliquely from the plane side (side from which the nozzle portion 23 protrudes), and FIG. 2B is a perspective view of the cap 12A viewed obliquely from the bottom surface side. It is. FIG. 3 is a front view of the cap 12A. FIG. 4 is a plan view of the cap 12A. FIG. 5 is a bottom view of the cap 12A. 6 is a cross-sectional view of the cap 12A cut along the cutting plane VI-VI shown in FIG. FIG. 7 is a diagram schematically showing the injection molding machine 40. FIG. 8 is a cross-sectional view of a mold 50 used when the cap 12A is injection molded.

  Hereinafter, preferred embodiments of the present invention will be described. In addition, this embodiment is only one embodiment of this invention, and it cannot be overemphasized that an embodiment can be changed in the range which does not change the summary of this invention.

[Blood device 10]
As shown in FIG. 1, the blood device 10 includes a main body 11, a cap 12 </ b> A, a cap 12 </ b> B, a hollow fiber bundle 13, and a hollow fiber support 14. The main body 11 has a substantially cylindrical shape. The internal space of the main body 11 is open on both sides in the axial direction 101 (the direction along the left-right direction in FIG. 1). In the present embodiment, the opening on the left side of FIG. 1 is for the blood inlet and the opening on the right side is for the blood outlet, but these are relative relationships. A cap 12A and a cap 12B are fitted into each opening of the main body 11 by a screw structure. The cap 12 </ b> A and the cap 12 </ b> B are liquid-tightly sealed by ultrasonic fusion while being fitted into the main body 11. In addition, it is also possible to seal liquid-tightly by providing packing between each cap 12A and 12B and the main body 11.

  A pair of hollow fiber supports 14 are provided in the vicinity of each opening of the main body 11. Note that the hollow fiber support 14 disposed on the left side in FIG. 1 does not appear in FIG. The pair of hollow fiber supports 14 supports both ends of the hollow fiber bundle 13 in the internal space of the main body 11 and is fitted in the internal space of the main body 11 in a liquid-tight manner.

  In the internal space of the main body 11, the space between the pair of hollow fiber supports 14 is held in a liquid-tight space by the hollow fiber support 14 and is externally provided by two ports 15 and 16 provided in the main body 11. Is open to Through the ports 15 and 16, the dialysate is circulated through the space between the pair of hollow fiber supports 14.

  The main body 11 is manufactured by injection molding using, for example, a thermoplastic resin as a raw material. As the thermoplastic resin, polypropylene resin, polyethylene resin, polycarbonate resin, polyethylene terephthalate resin, polyvinyl alcohol resin, ethylene vinyl alcohol copolymer, polyvinylidene chloride resin, nylon resin and the like are preferable, and polypropylene resin is more preferable. Polypropylene resin has excellent heat resistance and light transmittance. By molding the main body 11 from a light-transmitting thermoplastic resin, the inside of the main body 11 becomes visible from the outside. Thereby, the blood, dialysate, etc. which distribute | circulate the inside of the main body 11 are visually recognizable from the outside. Polypropylene resin is inexpensive and relatively easy to obtain.

  The hollow fiber bundle 13 is a bundle of hollow fibers in which a dialysis membrane is formed in a tubular shape. The hollow fiber is open at each end. Examples of the hollow fiber raw material include triacetate and polyethersulfone. The thickness of the hollow fiber, the type of membrane pressure length, and the like are appropriately set according to conditions such as the flow rate, viscosity, and patient symptoms of the blood circulating in the blood apparatus 10. In the internal space of the main body 11, blood flows from the hollow fiber support 14 to the opening side. The space on each opening side of the main body 11 is communicated by a hollow fiber bundle 13. Therefore, blood that has flowed in from one opening of the main body 11 can flow out of the other opening through the hollow fiber bundle 13.

[Cap 12A]
The cap 12A and the cap 12B are manufactured by injection molding using a thermoplastic resin as a raw material. The cap 12A and the cap 12B may have the same shape or may be different from each other. However, since the cap 12A and the cap 12B have the same shape in the present embodiment, the configuration will be described below using the cap 12A as an example.

  The material of the cap 12A is preferably a polypropylene resin, a polyethylene resin, a polycarbonate resin, a polyethylene terephthalate resin, a polyvinyl alcohol resin, an ethylene vinyl alcohol copolymer, a polyvinylidene chloride resin, a nylon resin, etc. More preferred. Polypropylene resin has excellent heat resistance and light transmittance. By molding the cap 12A from a light-transmitting thermoplastic resin, the inside of the main body 11 can be visually recognized from the outside through the cap 12A.

  As shown in FIGS. 2 to 6, the cap 12 </ b> A includes a cylindrical side portion 21, a lid portion 22, a nozzle portion 23, and a joint portion 26.

  The side part 21 is substantially cylindrical. The inner diameter of the side portion 21 corresponds to the outer diameter of the outer peripheral edge of the main body 11. Although not shown in detail in each drawing, a female screw is formed on the inner surface of the side portion 21 and can be screwed with a male screw formed on the outer surface of the opening periphery of the main body 11. The thickness along the radial direction of the side portion 21 (thickness A shown in FIG. 6) is constant over the circumferential direction 102 of the side portion 21.

  The opening facing the direction 101 </ b> A on one side of the axial direction 101 of the side portion 21 is closed by the lid portion 22. The opening facing the direction 101B on the other side of the axial direction 101 of the side portion 21 is not closed, and the end portion of the main body 11 and the cap 12A are fitted through the opening. There are two gate marks 28 on the edge 27 that defines the opening of the side portion 21 in the direction 101B. The gate marks 28 are arranged at equal intervals in the circumferential direction 102 of the side portion 21, in this embodiment, every 180 degrees. The gate mark 28 is formed on the edge portion 27 of the side portion 21 by the gate 52 (see FIG. 8) for flowing the molten thermoplastic resin into the mold 50 (see FIG. 8) when the cap 12A is injection-molded. It is the concave shape formed in the plane. The shape of the gate mark 28 is opposite to the shape of the gate 52.

  The gate mark 28 is a recess that is recessed toward the direction 101A in the plane in which the side portion 21 is the edge portion 27. The gate mark 28 includes a bottom surface 28 </ b> A and two side surfaces 28 </ b> B that connect the bottom surface 28 </ b> A and the edge portion 27. The side surface 28B intersects the bottom surface 28 at an obtuse angle. In the gate mark 28, the distance between the two side surfaces 28 </ b> B gradually decreases from the edge portion 27 toward the bottom surface 28. The size and shape of the gate mark 28 are appropriately set according to the size and thickness of the cap 12A, the viscosity of the thermoplastic resin, and the like.

  As shown in FIGS. 2 to 4 and 6, the lid portion 22 has a through hole 25 penetrating in the axial direction 101. The through hole 25 is located at the center of the disc-shaped lid portion 22. The lid portion 22 has a tapered portion 22A and a flat surface portion 22B around the through hole 25.

  As shown in FIG. 6, the tapered portion 22 </ b> A is a portion constituting a central portion around the through hole 25 in the lid portion 22. The tapered portion 22A has a tapered shape that protrudes outward (upward in FIG. 6) from the periphery of the through hole 25 to the flat portion 22B within a radius S1 centered on the central axis 103 of the cap 12A.

  The flat portion 22B is continuous with the tapered portion 22A on the outer peripheral side of the tapered portion 22A. The inner surface and the outer surface of the flat portion 22B are substantially orthogonal to the central axis 103 of the cap 12A.

  As shown in FIG. 1, the main body 11 is fitted inside the cap 12 </ b> A. The front end surface that defines the opening of the main body 11 is fused in a state of being in contact with the inside of the flat portion 22B of the cap 12A. Since the space between the main body 11 and the cap 12A is sealed in a liquid-tight manner by fusion, blood flowing inside the lid portion 22 does not flow out from between the main body 11 and the cap 12A. A state where the cap 12A is attached to the opening of the main body 11 is defined as an attachment state. In the attached state, the blood contact region 31 is a region where blood circulating in the main body 11 can contact on the inner surface of the lid portion 22. That is, blood flows into the blood device 10 from the nozzle portion 23 of the cap 12A. The blood first flows into the nozzle portion 23 from the outside of the blood apparatus 10. The blood flowing in from the nozzle part 23 flows into the space formed by the main body 11 and the cap 12A. In the space formed by the main body 11 and the cap 12A, the blood contacts the inner surface of the lid portion 22 of the cap 12A. On the inner surface of the lid portion 22 of the cap 12 </ b> A, a blood contact region 31 is a region where blood comes into contact. The blood that has passed through the main body 11 flows from the main body 11 into the space formed by the main body 11 and the cap 12B. In the space formed by the main body 11 and the cap 12B, the blood contacts the inner surface of the lid portion 22 of the cap 12B. On the inner surface of the lid portion 22 of the cap 12B, a blood contact region 31 is a region in contact with blood. The blood flows out of the blood apparatus 10 from the space formed by the main body 11 and the cap 12B through the nozzle portion 23 of the cap 12B.

  The main body 11 has a cylindrical shape. Both ends of the main body 11 in the axial direction of the main body 11 are annular end faces defined by outer and inner edges. The end surface of the main body 11 is a surface that intersects perpendicularly to the axial direction of the main body 11. The inner surface of the flat portion 22B in the cap 12A and the cap 12B is a surface that intersects perpendicularly to the axial direction of the cap 12A and the cap 12B main body 11. In the mounting state described above, the end surfaces of both ends of the main body 11 are fused with the inner surfaces of the flat portions 22B of the cap 12A and the cap 12B in contact with each other. For this reason, the blood contact region 31 is a region surrounded by the inner edge of the end surface of the main body 11 on the inner surface of the lid portion 22 of the cap 12A and the cap 12B. In the case where the packing is provided between the caps 12A and 12B and the main body 11 so as to be liquid-tightly sealed, the blood contact region 31 is surrounded by the packing on the inner surfaces of the cap portions 22 of the cap 12A and the cap 12B. This is the inner area.

  The main body 11 has a cylindrical shape with both ends open. In the attached state, the opening of the main body 11 is liquid-tightly sealed by the cap 12A and the cap 12B. The internal space of the main body 11 is a space formed by the main body 11 and the cap 12A and the cap 12B attached to the main body 11. The area where the blood contacts in the internal space of the main body 11 is the inner surface of the main body 11 and the inner surfaces of the cap 12A and the cap 12B. That is, the internal space of the main body 11 is a space surrounded by the surfaces of the inner surface of the main body 11 and the inner surfaces of the caps 12A and 12B that come into contact with blood. As described above, the surface of the inner surfaces of the cap 12A and the cap 12B that contacts the blood is the blood contact region 31. For this reason, the blood contact region 31 is a surface that partitions the internal space of the main body 11.

  As shown in FIGS. 2, 3, and 6, a plurality of ribs 29 are formed around the joint portion 26 on the outer surface of the lid portion 22. Eight ribs 29 are arranged radially at equal intervals around the joint 26. The number, size, and shape of the ribs 29 are not limited to this, and are appropriately set according to the size of the blood device 10 and the joint portion 26.

  As shown in FIGS. 2, 3, and 6, a nozzle portion 23 is provided around the through hole 25 of the lid portion 22. The nozzle portion 23 has a cylindrical shape with both ends opened, and defines a through-hole 25 at one end, and the other end projects from the outer surface of the lid portion 22 in the direction 101A. The thickness B along the radial direction of the nozzle portion 23 is constant over the circumferential direction 102. The inside and outside of the cap 12 </ b> A are communicated by the internal space of the nozzle portion 23.

  As shown in FIGS. 2 to 6, a joint portion 26 is provided around the nozzle portion 23 of the lid portion 22. The joint portion 26 has a cylindrical shape including the nozzle portion 23 and protrudes from the lid portion 22 in the direction 101A. A space for inserting a connector or the like connected to the nozzle portion 23 is formed between the joint portion 26 and the nozzle portion 23. As shown in FIG. 6, an internal thread is formed on the inner wall of the joint portion 26. The joint portion 26 is screwed with a connector or the like connected to the nozzle portion 23 by the female screw.

[Method of manufacturing cap 12A]
Below, the manufacturing method of the cap 12A is demonstrated, referring FIG.

  FIG. 7 is a schematic view of the injection molding machine 40. Since the configuration of the injection molding machine 40 is known, a detailed description is omitted here. The raw material thermoplastic resin pellets are put into the hopper 41. The pellet moves through the hopper 41 and into the cylinder 42. The pellet is heated to a predetermined temperature in the cylinder 42. The heated pellets melt.

  FIG. 8 is a cross-sectional view of a mold 50 used for injection molding of the cap 12A. The mold 50 includes a movable mold 44 and a fixed mold 45. The stationary mold 45 has two runners 51 inside. The tip of the runner 51 is a gate 52. The internal space of the runner 51 is opened at the gate 52. The gate 52 is located at the edge portion 27 in the side portion 21. The gate 52 is formed in two places. The gates 52 are arranged at regular intervals on the edge 27 in the circumferential direction. The distal end portion of the gate 52 is at a position where the depth D enters the internal space 56 of the mold 50 from the fixed side mold 45.

  The movable mold 44 is moved by the mold clamping device 46 and is brought into pressure contact with the fixed mold 45. The mold clamping device 46 fixes the movable side mold 44 and the fixed side mold 45 in a pressed state. The molten resin is pushed out from the cylinder 42 and flows into the internal space 53 of the runner 51. The molten resin flows into the internal space 56 through the internal space 53 and the gate 52 of the runner 51.

  In the present embodiment, gates 52 are provided at two locations corresponding to the edge portion 27 of the side portion 21 in the internal space 56 of the mold 50. The molten resin flows into the internal space 56 of the mold 50 corresponding to the side portion 21 from the two gates 52. Subsequently, the molten resin flows from the internal space 56 of the mold 50 corresponding to the side portion 21 to the internal space 56 of the mold 50 corresponding to the lid portion 22. In the internal space 56 corresponding to the lid portion 22, the molten resin that has flowed out from the respective gates 52 merges.

  In injection molding, if the time taken for the molten resin flowing from the gate 52 and flowing in the internal space 56 of the mold 50 to join is long, the temperature of the molten resin at the joining point is lowered, and a weld line is likely to be formed. . In the present embodiment, since the time taken for the molten resin flowing out from the respective gates 52 to merge is relatively short, a weld line is not formed at least in the blood contact region 31 on the inner surface of the lid portion 22.

  Subsequently, the molten resin joined at a position corresponding to the lid portion 22 in the internal space 56 of the mold 50 corresponds to the nozzle portion 23, the joint portion 26, and the side portion 21 via the internal space 56 corresponding to the lid portion 22. Into the internal space 56. After the molten resin is filled into the internal space 56 of the mold 50, the molten resin filled together with the mold 50 is cooled in a state where the movable side mold 44 and the fixed side mold 45 are fixed. The molten resin is solidified by cooling. After cooling, the movable mold 44 and the fixed mold 45 are pulled apart. By removing the solidified molten resin from the mold 50, the cap 12A is obtained.

[Effects of Embodiment]
In the present embodiment, the cap 12A and the cap 12B in which the weld line is not formed in the blood contact region 31 are obtained. When the blood device 10 is used, the possibility that the blood circulated through the blood device 10 stays or coagulates in the blood contact region 31 of the lid 22 is reduced. This prevents the appearance of the blood device 10 after use from deteriorating.

  Moreover, since the gate mark 28 is provided in the edge part 27 which divides the other opening of the side part 21, formation of the weld line in the blood contact region 31 is suppressed.

  Further, since the gate marks 28 are arranged at equal intervals in the circumferential direction 102 at the edge portion 27 of the side portion 21 of the cap 12A, 12B, the distance from the gate 52 to the point where the molten resin joins in the mold. And the time taken is about the same. For this reason, molten resin is easy to mix uniformly in a junction, and the formation of the weld line in the blood contact region 31 is further suppressed.

  Further, since the gate mark 28 is a recess, the cap 12A can be easily removed from the injection mold 50. Further, as compared with the case where the gate mark 28 protrudes, the processing for adjusting the shape can be omitted.

  Further, when a weld line is formed in the cap 12A, it is likely to be formed in the joint portion 26. Since the junction 26 is not a place where the blood circulated through the blood device 10 is in direct contact, no blood stays in the weld line.

  Moreover, the cover part 22 protrudes in the taper shape to the side in which the nozzle part 23 is provided. For this reason, since the molten resin easily flows from the lid portion 22 to the nozzle portion 23 in the injection molding, it is difficult to further form a weld line in the lid portion 22.

[Modification]

  In the above-described embodiment, the gate 52 is disposed on the plane that is the edge 27 of the side portion 21, but the gate 52 may be disposed on the outer peripheral surface of the side portion 21. Further, the gate mark 28 may have a shape such as a convex portion instead of a concave portion.

  In the above-described embodiment, the tapered portion 22A has a tapered shape protruding from the side portion 21 toward the direction 101A. However, the lid portion 22 may not necessarily be provided with a tapered shape.

  In the above-described embodiment, the joint portion 26 is provided around the nozzle portion 23, but the joint portion 26 is not necessarily provided.

  In the above-described embodiment, the dialyzer for hemodialysis is described as an example, but the blood device 10 may be another device through which blood is circulated, for example, a leukocyte removal filter.

DESCRIPTION OF SYMBOLS 10 Blood apparatus 11 Main body 12A Cap 12B Cap 22 Lid part 23 Nozzle part 25 Through-hole 26 Joint part 27 Edge part 28 Gate trace 31 Blood contact area

Claims (8)

A cap for a blood device that can be attached to an opening of a cylindrical body for a blood device, and is obtained by injection molding a thermoplastic resin,
A cylindrical side,
A lid portion that closes one opening in the axial direction of the side portion and has a through hole along the axial direction;
A cylindrical nozzle portion provided in the lid portion, the internal space of which communicates with the through hole of the lid portion;
The side portion has two gate marks on the edge portion defining the other opening in the axial direction,
The gate marks are arranged at equal intervals in the circumferential direction on the side part,
In the attachment state in which the blood device cap is attached to the opening of the main body, the weld line by the injection molding is not formed in the blood contact area where the blood circulating in the main body can contact the inner surface of the lid portion. Cap for blood devices.   The blood device cap according to claim 1, wherein the blood contact region is a surface that divides an internal space of the main body in the attached state. The blood device cap according to claim 1 , wherein the gate mark is a concave portion in which the edge portion is recessed along the axial direction. The blood apparatus cap according to any one of claims 1 to 3 , wherein a weld line is formed on the side portion. The blood device cap according to any one of claims 1 to 4 , further comprising a cylindrical joint provided on the lid and surrounding the outside of the nozzle. The blood device cap according to claim 5 , wherein an internal thread is formed on an inner wall of the joint portion. The blood device cap according to any one of claims 1 to 6 , wherein the lid portion projects in a tapered shape toward one side in the axial direction. A blood device cap according to any one of claims 1 to 7 ,
A cylindrical main body through which blood is circulated,
A blood device having the blood device cap attached to the opening of the main body.

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