JP6543697B2 - ２，２，２−トリフルオロエチル−チアジアジン類 - Google Patents
２，２，２−トリフルオロエチル−チアジアジン類 Download PDFInfo
- Publication number
- JP6543697B2 JP6543697B2 JP2017506993A JP2017506993A JP6543697B2 JP 6543697 B2 JP6543697 B2 JP 6543697B2 JP 2017506993 A JP2017506993 A JP 2017506993A JP 2017506993 A JP2017506993 A JP 2017506993A JP 6543697 B2 JP6543697 B2 JP 6543697B2
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- fluoropyridin
- amino
- dimethyl
- trifluoroethylimino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(*)Cc(nc1C(C)(C2)N=C(N)N(*)S2(=N**)=O)ccc1F Chemical compound CC(*)Cc(nc1C(C)(C2)N=C(N)N(*)S2(=N**)=O)ccc1F 0.000 description 7
- KCWCNAKODOEVQE-UHFFFAOYSA-N CC(C1)(c2nc(NC(c(c(C)c3)ncc3C#N)=O)ccc2F)N=C(N)N(CC(F)(F)F)S1(=NC)=O Chemical compound CC(C1)(c2nc(NC(c(c(C)c3)ncc3C#N)=O)ccc2F)N=C(N)N(CC(F)(F)F)S1(=NC)=O KCWCNAKODOEVQE-UHFFFAOYSA-N 0.000 description 1
- AOLSWTLAHZUERT-QXPMRUIWSA-N CC[Si+](CC)(CC)c1cc(Br)nc(C(C)(CS(N(CC(F)(F)F)Cc(ccc(OC)c2)c2OC)(=NC)=O)N[S@@](C(C)(C)C)=O)c1F Chemical compound CC[Si+](CC)(CC)c1cc(Br)nc(C(C)(CS(N(CC(F)(F)F)Cc(ccc(OC)c2)c2OC)(=NC)=O)N[S@@](C(C)(C)C)=O)c1F AOLSWTLAHZUERT-QXPMRUIWSA-N 0.000 description 1
- SGDLUNLGSZJAMO-QXPMRUIWSA-N CC[Si](CC)(CC)c1cc(Br)nc(C(C)(CS(N(CC(F)(F)F)Cc(ccc(OC)c2)c2OC)(=NC)=O)N[S@@](C(C)(C)C)=O)c1F Chemical compound CC[Si](CC)(CC)c1cc(Br)nc(C(C)(CS(N(CC(F)(F)F)Cc(ccc(OC)c2)c2OC)(=NC)=O)N[S@@](C(C)(C)C)=O)c1F SGDLUNLGSZJAMO-QXPMRUIWSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N OC(C(F)(F)F)=O Chemical compound OC(C(F)(F)F)=O DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14181123 | 2014-08-15 | ||
| EP14181123.2 | 2014-08-15 | ||
| PCT/EP2015/068506 WO2016023927A1 (en) | 2014-08-15 | 2015-08-12 | 2,2,2-trifluoroethyl-thiadiazines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524006A JP2017524006A (ja) | 2017-08-24 |
| JP2017524006A5 JP2017524006A5 (https=) | 2018-07-26 |
| JP6543697B2 true JP6543697B2 (ja) | 2019-07-10 |
Family
ID=51302940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017506993A Expired - Fee Related JP6543697B2 (ja) | 2014-08-15 | 2015-08-12 | ２，２，２−トリフルオロエチル−チアジアジン類 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9896438B2 (https=) |
| EP (1) | EP3180330B1 (https=) |
| JP (1) | JP6543697B2 (https=) |
| KR (1) | KR20170043581A (https=) |
| CN (1) | CN106459006B (https=) |
| BR (1) | BR112016026814A8 (https=) |
| CA (1) | CA2952160A1 (https=) |
| MX (1) | MX375329B (https=) |
| RU (1) | RU2692102C2 (https=) |
| WO (1) | WO2016023927A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109180672A (zh) * | 2018-09-29 | 2019-01-11 | 广东东阳光药业有限公司 | 亚氨基噻二嗪二氧化物衍生物及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19500558A1 (de) * | 1995-01-11 | 1996-07-18 | Merck Patent Gmbh | 3-Alkoxycarbonyl-thiadiazinone |
| EP2485590B1 (en) | 2009-10-08 | 2015-01-07 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
| UA108363C2 (uk) * | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| WO2014150331A1 (en) * | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | S-imino-s-oxo iminothiazine compounds as bace inhibitors, compositions, and their use |
| US9428476B2 (en) * | 2013-03-15 | 2016-08-30 | Merck Sharp & Dohme Corp. | S-imino-S-oxo-iminothiadiazine compounds as BACE inhibitors, compositions, and their use |
| CN105683199B (zh) * | 2013-12-20 | 2018-06-26 | 豪夫迈·罗氏有限公司 | 5-芳基-1-亚氨基-1-氧代-[1，2，4]噻二嗪 |
-
2015
- 2015-08-12 US US15/502,044 patent/US9896438B2/en not_active Expired - Fee Related
- 2015-08-12 RU RU2017107495A patent/RU2692102C2/ru active
- 2015-08-12 MX MX2016016061A patent/MX375329B/es active IP Right Grant
- 2015-08-12 KR KR1020177006946A patent/KR20170043581A/ko not_active Ceased
- 2015-08-12 EP EP15748252.2A patent/EP3180330B1/en not_active Not-in-force
- 2015-08-12 JP JP2017506993A patent/JP6543697B2/ja not_active Expired - Fee Related
- 2015-08-12 WO PCT/EP2015/068506 patent/WO2016023927A1/en not_active Ceased
- 2015-08-12 CN CN201580032183.8A patent/CN106459006B/zh not_active Expired - Fee Related
- 2015-08-12 BR BR112016026814A patent/BR112016026814A8/pt active Search and Examination
- 2015-08-12 CA CA2952160A patent/CA2952160A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20170226091A1 (en) | 2017-08-10 |
| EP3180330B1 (en) | 2021-03-03 |
| CA2952160A1 (en) | 2016-02-18 |
| MX2016016061A (es) | 2017-03-10 |
| BR112016026814A2 (pt) | 2017-08-15 |
| WO2016023927A1 (en) | 2016-02-18 |
| BR112016026814A8 (pt) | 2021-07-20 |
| MX375329B (es) | 2025-03-06 |
| KR20170043581A (ko) | 2017-04-21 |
| CN106459006A (zh) | 2017-02-22 |
| EP3180330A1 (en) | 2017-06-21 |
| CN106459006B (zh) | 2020-02-11 |
| US9896438B2 (en) | 2018-02-20 |
| RU2017107495A3 (https=) | 2019-02-25 |
| RU2017107495A (ru) | 2018-09-17 |
| RU2692102C2 (ru) | 2019-06-21 |
| JP2017524006A (ja) | 2017-08-24 |
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