JP6535336B2 - 放射性核種の処理・追跡システム - Google Patents
放射性核種の処理・追跡システム Download PDFInfo
- Publication number
- JP6535336B2 JP6535336B2 JP2016552244A JP2016552244A JP6535336B2 JP 6535336 B2 JP6535336 B2 JP 6535336B2 JP 2016552244 A JP2016552244 A JP 2016552244A JP 2016552244 A JP2016552244 A JP 2016552244A JP 6535336 B2 JP6535336 B2 JP 6535336B2
- Authority
- JP
- Japan
- Prior art keywords
- radionuclide
- container
- daughter
- parent
- daughter radionuclide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000012545 processing Methods 0.000 title claims description 27
- 238000000926 separation method Methods 0.000 claims description 32
- 239000012530 fluid Substances 0.000 claims description 10
- 238000010586 diagram Methods 0.000 claims description 8
- 230000003213 activating effect Effects 0.000 claims 1
- 230000003068 static effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 17
- 239000000047 product Substances 0.000 description 15
- 238000004519 manufacturing process Methods 0.000 description 10
- 239000003814 drug Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000012857 radioactive material Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 238000009206 nuclear medicine Methods 0.000 description 4
- 239000000941 radioactive substance Substances 0.000 description 4
- 239000000700 radioactive tracer Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000004590 computer program Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000007905 drug manufacturing Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000013475 authorization Methods 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 229940126534 drug product Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000007257 malfunction Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000013024 troubleshooting Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- WUAPFZMCVAUBPE-NJFSPNSNSA-N 188Re Chemical compound [188Re] WUAPFZMCVAUBPE-NJFSPNSNSA-N 0.000 description 1
- 101100480513 Caenorhabditis elegans tag-52 gene Proteins 0.000 description 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 1
- VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical compound [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- JCXGWMGPZLAOME-AKLPVKDBSA-N bismuth-212 Chemical compound [212Bi] JCXGWMGPZLAOME-AKLPVKDBSA-N 0.000 description 1
- JCXGWMGPZLAOME-RNFDNDRNSA-N bismuth-213 Chemical compound [213Bi] JCXGWMGPZLAOME-RNFDNDRNSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- YCKRFDGAMUMZLT-BJUDXGSMSA-N fluorine-18 atom Chemical compound [18F] YCKRFDGAMUMZLT-BJUDXGSMSA-N 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229940055742 indium-111 Drugs 0.000 description 1
- APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000011824 nuclear material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 201000009032 substance abuse Diseases 0.000 description 1
- 229940056501 technetium 99m Drugs 0.000 description 1
- BKVIYDNLLOSFOA-OIOBTWANSA-N thallium-201 Chemical compound [201Tl] BKVIYDNLLOSFOA-OIOBTWANSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F5/00—Transportable or portable shielded containers
- G21F5/015—Transportable or portable shielded containers for storing radioactive sources, e.g. source carriers for irradiation units; Radioisotope containers
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F5/00—Transportable or portable shielded containers
- G21F5/06—Details of, or accessories to, the containers
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
- G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for
- G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for as tracers
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
本願は、2013年10月30日に出願された米国特許仮出願第61/897,482号(係属中)の一部継続出願である。
時間の経過につれて娘放射性核種に崩壊する親放射性核種を有する容器と、
娘放射性核種を親放射性核種から分離する分離カラムを収容した容器と、
分離された娘放射性核種を有する容器と、
処理用流体のための複数の容器と、
親放射性核種容器、娘放射性核種容器、分離カラム容器及び複数の処理用流体容器のうちの少なくとも2つを交互に連結することによって娘放射性核種を親放射性核種から分離して娘放射性核種を娘放射性核種容器内に送り込むよう働く複数の弁及び少なくとも1つのポンプと、
複数のRFIDタグであって、複数のRFIFタグのうちの一RFIDタグは、娘放射性核種容器及び分離カラムの各々に取り付けられ、複数のRFIDタグと、
ホストコンピュータと、
複数のRFIDタグの各々の識別子、複数の弁の各々の識別子を読み取ると共に複数の弁の各々の位置を読み取ってこれら識別子及び位置を追跡ファイル中に保存するプログラム式プロセッサとを有することを特徴とする装置が提供される。
時間の経過につれて娘放射性核種に崩壊する親放射性核種と、
娘放射性核種を親放射性核種から分離する分離カラムと、
娘放射性核種を親放射性核種から分離してこの娘放射性核種を娘放射性核種容器内に送り込む複数の弁及びポンプと、
複数のRFIDタグであって、複数のRFIFタグのうちの一RFIDタグは、娘放射性核種容器及び分離カラムの各々に取り付けられる前記複数のRFIDタグと、
複数のRFIDタグの各々の識別子及び複数の弁の各々の位置を読み取ってこれら識別子及び位置を追跡ファイル中に保存するプログラム式プロセッサとを有することを特徴とする装置が提供される。
Claims (10)
- 装置であって、
時間の経過につれて娘放射性核種に崩壊する親放射性核種を有する親放射性核種容器と、
前記娘放射性核種を前記親放射性核種から分離する分離カラムを収容した分離カラム容器と、
前記分離された娘放射性核種を有する娘放射性核種容器と、
処理用流体のための複数の処理用容器と、
前記親放射性核種容器、前記娘放射性核種容器、前記分離カラム容器及び前記複数の処理用容器のうちの少なくとも2つを交互に連結することによって前記娘放射性核種を前記親放射性核種から分離して前記娘放射性核種を前記娘放射性核種容器内に送り込むよう働く複数の弁及び少なくとも1つのポンプと、
複数のRFIDタグであって、前記複数のRFIDタグのうちの一RFIDタグは、前記娘放射性核種容器及び前記分離カラムの各々に取り付けられ、前記複数のRFIDタグと、
ホストコンピュータと、
前記複数のRFIDタグの各々の識別子、前記複数の弁の各々の識別子及び位置を読み取ると共に前記複数の弁の各々の位置を読み取って前記識別子及び前記位置を追跡ファイル中に保存するプログラム式プロセッサとを有する、装置。 - 前記複数の弁を順次作動させる生成物プロセッサを更に有する、請求項1記載の装置。
- 前記分離カラム容器の入れ物内に収納されていて前記分離カラム容器の前記RFIDタグの前記識別子を読み取るRFID読取り装置を更に有する、請求項1記載の装置。
- 前記娘放射性核種容器の入れ物内に収納されていて前記娘放射性核種容器の前記RFIDタグの前記識別子を読み取るRFID読取り装置を更に有する、請求項1記載の装置。
- 複数の処理プログラムを更に有し、前記複数の処理プログラムのうちの少なくとも1つは、前記娘放射性核種を親放射性核種から分離する1組のステップを定めている、請求項1記載の装置。
- ユーザにより選択可能に前記複数の処理プログラムの各々を示すディスプレイを更に有する、請求項5記載の装置。
- 前記ディスプレイ上に表されていて前記装置を通る放射性核種の瞬時流れを示す流れ図を更に有する、請求項6記載の装置。
- 前記流れ図は、静的ディスプレイであり、所望の流れの経路だけが強調表示される、請求項7記載の装置。
- 各計器イベントの記録を前記追跡ファイル中に保存するプロセッサを更に有する、請求項1記載の装置。
- 装置であって、
時間の経過につれて娘放射性核種に崩壊する親放射性核種と、
前記娘放射性核種を前記親放射性核種から分離する分離カラムと、
前記娘放射性核種を前記親放射性核種から分離して該娘放射性核種を娘放射性核種容器内に送り込む複数の弁及びポンプと、
複数のRFIDタグであって、前記複数のRFIDタグのうちの一RFIDタグは、親放射性核種容器及び前記分離カラムの各々に取り付けられる前記複数のRFIDタグと、
前記複数のRFIDタグの各々の識別子及び前記複数の弁の各々の位置を読み取って前記識別子及び前記位置を追跡ファイル中に保存するプログラム式プロセッサとを有する、装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361897482P | 2013-10-30 | 2013-10-30 | |
US61/897,482 | 2013-10-30 | ||
PCT/US2014/063223 WO2015066360A1 (en) | 2013-10-30 | 2014-10-30 | System for processing and tracking radionuclides |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017503183A JP2017503183A (ja) | 2017-01-26 |
JP6535336B2 true JP6535336B2 (ja) | 2019-06-26 |
Family
ID=53005136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016552244A Active JP6535336B2 (ja) | 2013-10-30 | 2014-10-30 | 放射性核種の処理・追跡システム |
Country Status (8)
Country | Link |
---|---|
US (1) | US9299466B2 (ja) |
EP (1) | EP3062826B1 (ja) |
JP (1) | JP6535336B2 (ja) |
KR (1) | KR102373194B1 (ja) |
CN (1) | CN105682691B (ja) |
AU (1) | AU2014342235B2 (ja) |
CA (1) | CA2928838C (ja) |
WO (1) | WO2015066360A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2990956B1 (fr) * | 2012-05-24 | 2014-07-04 | Areva Med Sas | Procede et appareil pour la production de plomb 212 a usage medical |
DE102016103915A1 (de) * | 2016-03-04 | 2017-09-07 | Miele & Cie. Kg | Autarke Prozessdokumentations- und Freigabe-Einrichtung |
CN111709498A (zh) * | 2020-04-24 | 2020-09-25 | 青岛东卡环保工程技术有限公司 | 一种采用rfid实现中低放废物处理的废物跟踪系统及方法 |
KR102471133B1 (ko) | 2021-01-29 | 2022-11-25 | 한국원자력의학원 | 방사선원으로부터 얻어진 알파선 스펙트럼을 분석하는 방법 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5154897A (en) * | 1991-03-06 | 1992-10-13 | University Of Missouri | Method and apparatus for the generation of radioisotopes |
WO2003000375A1 (en) * | 2001-06-22 | 2003-01-03 | Pg Research Foundation, Inc. | Compact automated radionuclide separator |
US20040051368A1 (en) * | 2002-09-17 | 2004-03-18 | Jimmy Caputo | Systems and methods for programming pumps |
US20060004491A1 (en) * | 2003-08-08 | 2006-01-05 | Welch Michael J | Automated separation, purification and labeling system for 60Cu, 61Cu and 64Cu radionuclides and recovery thereof |
EP1896098A2 (en) * | 2005-05-16 | 2008-03-12 | Mallinckrodt, Inc. | Radiopharmaceutical pigs and portable powered injectors |
WO2007041017A1 (en) * | 2005-10-03 | 2007-04-12 | Mallinckrodt Inc. | Radiopharmaceutical system and method utilizing radio-frequency identification tags |
US20080260580A1 (en) * | 2005-10-31 | 2008-10-23 | Medi-Physics, Inc. | Method and System for Radiopharmaceutical Kit Preparation |
US7586102B2 (en) * | 2006-08-14 | 2009-09-08 | Board Of Regents The University Of Texas System | Automated system for formulating radiopharmaceuticals |
ES2677024T3 (es) * | 2007-01-01 | 2018-07-27 | Bayer Healthcare Llc | Sistemas para generación, preparación, transporte y administración de productos radiofarmacéuticos integrados |
US8708352B2 (en) * | 2008-06-11 | 2014-04-29 | Bracco Diagnostics Inc. | Cabinet structure configurations for infusion systems |
SG10202109848VA (en) * | 2008-06-11 | 2021-10-28 | Bracco Diagnostics Inc | Infusion systems including computer-facilitated maintenance and/or operation |
CA2738945A1 (en) * | 2008-09-30 | 2010-04-08 | Mallinckrodt Inc. | Drop-in pig injector |
EP2416821B1 (en) * | 2009-04-08 | 2015-12-02 | Liebel-Flarsheim Company LLC | Multi-dose medical fluid injection system having patient-specific tubing set with use indicator |
CA2782608A1 (en) * | 2009-12-07 | 2011-10-13 | Medi-Physics, Inc. | Multiple generator elution system |
FR2995536B1 (fr) * | 2012-09-17 | 2014-09-26 | Lemer Prot Anti X Par Abreviation Soc Lemer Pax | Unite medicale pour l'injection de rubidium 82 a un patient |
US20150165341A1 (en) * | 2013-10-30 | 2015-06-18 | NorthStar Medical Radionuclides LLC | Separator cartridge for radionuclide |
WO2015066356A1 (en) * | 2013-10-30 | 2015-05-07 | NorthStar Medical Radioisotopes LLC | Product cartridge for radionuclide |
-
2014
- 2014-10-30 KR KR1020167014450A patent/KR102373194B1/ko active IP Right Grant
- 2014-10-30 JP JP2016552244A patent/JP6535336B2/ja active Active
- 2014-10-30 AU AU2014342235A patent/AU2014342235B2/en active Active
- 2014-10-30 CA CA2928838A patent/CA2928838C/en active Active
- 2014-10-30 WO PCT/US2014/063223 patent/WO2015066360A1/en active Application Filing
- 2014-10-30 CN CN201480059679.XA patent/CN105682691B/zh active Active
- 2014-10-30 EP EP14857830.5A patent/EP3062826B1/en active Active
- 2014-10-30 US US14/528,914 patent/US9299466B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3062826B1 (en) | 2018-09-19 |
KR20160079855A (ko) | 2016-07-06 |
US9299466B2 (en) | 2016-03-29 |
US20150162106A1 (en) | 2015-06-11 |
CA2928838C (en) | 2022-05-17 |
AU2014342235B2 (en) | 2020-12-24 |
EP3062826A1 (en) | 2016-09-07 |
CN105682691B (zh) | 2019-10-11 |
CA2928838A1 (en) | 2015-05-07 |
WO2015066360A1 (en) | 2015-05-07 |
EP3062826A4 (en) | 2017-05-17 |
JP2017503183A (ja) | 2017-01-26 |
KR102373194B1 (ko) | 2022-03-10 |
CN105682691A (zh) | 2016-06-15 |
AU2014342235A1 (en) | 2016-05-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104784770B (zh) | 包括计算机辅助维护和/或操作的输注系统 | |
JP6535336B2 (ja) | 放射性核種の処理・追跡システム | |
CN103415853B (zh) | 收集统计和/或维护信息的方法和系统及交换数据的方法 | |
CA2590665C (en) | Integrated pharmaceutical production, quality assurance, and safety system (iqs) | |
EP3062840B1 (en) | Product cartridge for radionuclide | |
JP4309254B2 (ja) | 小型の自動化された放射性核種セパレータ | |
EP3714907A1 (en) | Elution protocols and dosages for radiopharmaceutical elution system | |
RU2638527C2 (ru) | Медицинская установка для введения пациенту рубидия-82 | |
EP3751584B1 (en) | Security mechanisms for radiopharmaceutical elution system and elution process | |
WO2023159229A1 (en) | System, method and device for delivery of a therapeutic or diagnostic agent |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20170425 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20171011 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20180813 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180827 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20181126 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190125 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190516 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190531 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6535336 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |