JP6529971B2 - 気管支疾患の治療のための胸腔鏡検査方法 - Google Patents
気管支疾患の治療のための胸腔鏡検査方法 Download PDFInfo
- Publication number
- JP6529971B2 JP6529971B2 JP2016532099A JP2016532099A JP6529971B2 JP 6529971 B2 JP6529971 B2 JP 6529971B2 JP 2016532099 A JP2016532099 A JP 2016532099A JP 2016532099 A JP2016532099 A JP 2016532099A JP 6529971 B2 JP6529971 B2 JP 6529971B2
- Authority
- JP
- Japan
- Prior art keywords
- energy
- end effector
- bronchial
- bronchus
- contact
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title description 65
- 238000011282 treatment Methods 0.000 title description 29
- 208000014181 Bronchial disease Diseases 0.000 title description 3
- 239000012636 effector Substances 0.000 claims description 151
- 210000005036 nerve Anatomy 0.000 claims description 72
- 238000010438 heat treatment Methods 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 12
- 210000000115 thoracic cavity Anatomy 0.000 claims description 11
- 239000012530 fluid Substances 0.000 claims description 9
- 208000003098 Ganglion Cysts Diseases 0.000 claims description 8
- 208000019693 Lung disease Diseases 0.000 claims description 8
- 208000005400 Synovial Cyst Diseases 0.000 claims description 8
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims description 8
- 229910001000 nickel titanium Inorganic materials 0.000 claims description 7
- 238000002604 ultrasonography Methods 0.000 claims description 7
- 230000005855 radiation Effects 0.000 claims description 6
- 230000002829 reductive effect Effects 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 238000013532 laser treatment Methods 0.000 claims description 4
- 230000000926 neurological effect Effects 0.000 claims 1
- 210000000621 bronchi Anatomy 0.000 description 96
- 230000001537 neural effect Effects 0.000 description 46
- 210000004072 lung Anatomy 0.000 description 29
- 210000000609 ganglia Anatomy 0.000 description 17
- 208000006673 asthma Diseases 0.000 description 15
- 230000006378 damage Effects 0.000 description 9
- 238000001356 surgical procedure Methods 0.000 description 8
- 210000001186 vagus nerve Anatomy 0.000 description 8
- 206010006458 Bronchitis chronic Diseases 0.000 description 7
- 206010006451 bronchitis Diseases 0.000 description 7
- 208000007451 chronic bronchitis Diseases 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000008602 contraction Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 210000002460 smooth muscle Anatomy 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- 210000000779 thoracic wall Anatomy 0.000 description 5
- 230000000007 visual effect Effects 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 238000002679 ablation Methods 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 210000003169 central nervous system Anatomy 0.000 description 4
- 210000000038 chest Anatomy 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 230000001734 parasympathetic effect Effects 0.000 description 4
- 210000001428 peripheral nervous system Anatomy 0.000 description 4
- 230000002685 pulmonary effect Effects 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 210000003403 autonomic nervous system Anatomy 0.000 description 3
- 238000005452 bending Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 239000002581 neurotoxin Substances 0.000 description 3
- 231100000618 neurotoxin Toxicity 0.000 description 3
- 210000001002 parasympathetic nervous system Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 3
- 210000001562 sternum Anatomy 0.000 description 3
- 210000003437 trachea Anatomy 0.000 description 3
- 238000004804 winding Methods 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 230000000368 destabilizing effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004520 electroporation Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 238000013021 overheating Methods 0.000 description 2
- 210000000192 parasympathetic ganglia Anatomy 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 210000001991 scapula Anatomy 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 101710117542 Botulinum neurotoxin type A Proteins 0.000 description 1
- 206010006482 Bronchospasm Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 101710138657 Neurotoxin Proteins 0.000 description 1
- 208000011623 Obstructive Lung disease Diseases 0.000 description 1
- 208000004550 Postoperative Pain Diseases 0.000 description 1
- 108010057266 Type A Botulinum Toxins Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000005039 airway nerve Anatomy 0.000 description 1
- 210000005091 airway smooth muscle Anatomy 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229940089093 botox Drugs 0.000 description 1
- 229940094657 botulinum toxin type a Drugs 0.000 description 1
- 210000000424 bronchial epithelial cell Anatomy 0.000 description 1
- 230000007885 bronchoconstriction Effects 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 238000002681 cryosurgery Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- -1 for example Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000035874 hyperreactivity Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000030214 innervation Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 231100000189 neurotoxic Toxicity 0.000 description 1
- 230000002887 neurotoxic effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000002355 open surgical procedure Methods 0.000 description 1
- 210000005037 parasympathetic nerve Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000005381 potential energy Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007384 vagal nerve stimulation Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1442—Probes having pivoting end effectors, e.g. forceps
- A61B18/1445—Probes having pivoting end effectors, e.g. forceps at the distal end of a shaft, e.g. forceps or scissors at the end of a rigid rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
- A61B18/082—Probes or electrodes therefor
- A61B18/085—Forceps, scissors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/361—Image-producing devices, e.g. surgical cameras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00434—Neural system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00541—Lung or bronchi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B2018/044—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating the surgical action being effected by a circulating hot fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/142—Electrodes having a specific shape at least partly surrounding the target, e.g. concave, curved or in the form of a cave
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1422—Hook
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1435—Spiral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/144—Wire
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/1861—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument inserted into a body lumen or cavity, e.g. a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
- A61N2007/003—Destruction of nerve tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Plasma & Fusion (AREA)
- Electromagnetism (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Surgical Instruments (AREA)
- Radiation-Therapy Devices (AREA)
Description
(1) 肺疾患を治療する方法であって、
a.装置を、患者の隣接する肋骨経由、胸骨上、又は胸壁経由、から選択される位置でその長さの少なくとも一部分を通すことによって患者の胸腔に挿入する工程であって、前記装置はエンドエフェクタ及びそれに固定されるエネルギー源を有する、工程と、前記エンドエフェクタを気管支セグメント上にある神経成分の近位に、又は神経成分と接して位置合わせする工程と、前記エネルギー源からのエネルギーを、前記エンドエフェクタを介して前記神経成分に付与する工程と、を含む、方法。
(2) 前記エンドエフェクタは、中に気管支を収容するようにサイズ決めされた少なくとも1つの半円形を有する、実施態様1に記載の方法。
(3) 前記エンドエフェクタは、中央通路を形成するように位置合わせし、かつ中に気管支を収容するようにサイズ決めされた2つの半円形を有する、実施態様1又は2に記載の方法。
(4) 前記エンドエフェクタは、互いに対して移動可能な2つの要素を含み、前記2つの要素は、それらの間において気管支セグメントの外面に接するように構成されてもよい、実施態様1〜3のいずれかに記載の方法。
(5) 前記エンドエフェクタは、前記気管支セグメントの少なくとも一部分の周りに巻き付けられるように変形可能又は柔軟である、実施態様1に記載の方法。
(7) 前記エンドエフェクタは圧縮可能である、実施態様1〜6のいずれかに記載の方法。
(8) 前記装置を患者の体内に、トロカールを介して、又は送達ポートを介して挿入する工程を更に含む、実施態様1〜7のいずれかに記載の方法。
(9) 前記エンドエフェクタは、前記トロカール又は送達ポートを介して挿入される前に成形され、かつ前記トロカール又は送達ポートから出る際に拡張する、実施態様8に記載の方法。
(10) 前記エンドエフェクタは、前記カテーテル又は送達ポートを介して挿入される際に、縮小径に圧縮され、かつ前記カテーテル又は送達ポートから出る際に拡張する、実施態様8に記載の方法。
(12) 前記方法は、ビデオ補助胸腔鏡下手術手技を含む、実施態様1〜11のいずれかに記載の方法。
(13) 前記エンドエフェクタは、少なくとも2つの神経成分に接触する、実施態様1〜12のいずれかに記載の方法。
(14) 前記神経成分は、神経節又は叢を含む、実施態様1〜13のいずれかに記載の方法。
(15) 前記エンドエフェクタは、実質的に前記気管支セグメントを包囲する、実施態様1〜14のいずれかに記載の方法。
(17) 前記エネルギーは、前記エンドエフェクタに配設される複数の電極を介して付与される、実施態様1〜16のいずれかに記載の方法。
(18) 前記エネルギーの付与は、温度上昇をもたらし、かつ前記温度は約65℃又はそれ以上である、実施態様1〜17のいずれかに記載の方法。
(19) 前記神経成分への前記エネルギーの付与は、前記神経成分の切除をもたらす、実施態様1〜18のいずれかに記載の方法。
(20) 肺疾患を治療する装置であって、
a.近位端及び遠位端を有する延長体と、
b.前記遠位端のエンドエフェクタと、
c.前記エンドエフェクタにエネルギーを供給するエネルギー源と、を含み、
前記エンドエフェクタは、患者の胸腔に入り、気管支セグメントの少なくとも一部分上に位置する神経成分に接触し、前記神経成分を治療するために前記気管支セグメントの外面にエネルギーを付与するようにサイズ決めされ、かつ成形されている、装置。
(22) 前記エンドエフェクタは、中央通路を形成するように位置合わせし、かつ中に気管支セグメントを収容するようにサイズ決めされた2つの半円形を有する、実施態様20又は21に記載の装置。
(23) 前記エンドエフェクタは、互いに対して移動可能な2つの要素を含み、前記2つの要素は、それらの間において気管支セグメントの外面に接するように構成されてもよい、実施態様20〜22のいずれかに記載の装置。
(24) 前記エンドエフェクタは、前記気管支セグメントの少なくとも一部分の周りに巻き付けられるように変形可能又は柔軟である、実施態様23に記載の装置。
(25) 前記神経成分は、気管支セグメントの表面に、又は気管支セグメントの表面上に位置する神経節又は叢を含む、実施態様20〜24のいずれかに記載の装置。
(27) 前記エンドエフェクタは圧縮可能である、実施態様20〜26のいずれかに記載の装置。
(28) 前記装置は、カテーテル又は送達ポートを介して患者の体内に挿入されるように圧縮されてもよい、実施態様20〜27のいずれかに記載の装置。
(29) 前記エンドエフェクタは、前記カテーテル又は送達ポートを介して挿入される際に縮小径に圧縮され、かつ前記カテーテル又は送達ポートから出る際に拡張する、実施態様28に記載の装置。
(30) 前記エンドエフェクタは、前記気管支セグメントの外面を実質的に包囲する、実施態様20〜29のいずれかに記載の装置。
(32) 前記エネルギーは、前記エンドエフェクタの複数の電極を介して付与されてもよい、実施態様20〜31のいずれかに記載の装置。
(33) 前記エネルギーの付与は、温度上昇をもたらし、前記温度は約65℃又はそれ以上である、実施態様20〜32のいずれかに記載の装置。
(34) 前記エンドエフェクタは、ニチノールで構成されている、実施態様20に記載の装置。
Claims (13)
- 肺疾患を治療する装置であって、
a.近位端及び遠位端を有する延長体と、
b.前記遠位端のエンドエフェクタと、
c.前記エンドエフェクタにエネルギーを供給するエネルギー源と、を含み、
前記エンドエフェクタは、患者の胸腔に入り、気管支セグメントの少なくとも一部分上に位置する神経成分に接触し、前記神経成分を治療するために前記気管支セグメントの外面にエネルギーを付与するようにサイズ決めされ、かつ成形されており、
前記エンドエフェクタは、前記延長体の前記遠位端から遠位方向に延在する第1接触要素および前記延長体の前記遠位端から遠位方向に延在する第2接触要素を含み、前記第1接触要素は、前記第1接触要素の内面である第1接触面を含み、前記第2接触要素は、前記第2接触要素の内面である第2接触面を含み、前記第1接触面および前記第2接触面は、前記気管支セグメントの前記外面と接触し、前記エンドエフェクタは、前記延長体に対して前記延長体の長手方向軸の周りに回転することができる、装置。 - 前記第1接触要素および前記第2接触要素は、半円形である、請求項1に記載の装置。
- 前記第1接触面および前記第2接触面の少なくとも1つは、内部に流体が導入されている嚢状接触面である、請求項1または2に記載の装置。
- 前記神経成分は、前記気管支セグメントの表面に、又は前記気管支セグメントの前記表面上に位置する神経節又は叢を含む、請求項1〜3のいずれか一項に記載の装置。
- 前記エンドエフェクタは、前記気管支セグメントの表面に沿うように前記エンドエフェクタの表面上に材料を含む、請求項1〜4のいずれか一項に記載の装置。
- 前記エンドエフェクタは圧縮可能である、請求項1〜5のいずれか一項に記載の装置。
- 前記装置は、カテーテル又は送達ポートを介して患者の体内に挿入されるように圧縮される、請求項1〜6のいずれか一項に記載の装置。
- 前記エンドエフェクタは、前記カテーテル又は前記送達ポートを介して挿入される際に縮小径に圧縮され、かつ前記カテーテル又は前記送達ポートから出る際に拡張する、請求項7に記載の装置。
- 前記エンドエフェクタは、前記気管支セグメントの前記外面を実質的に包囲する、請求項1〜8のいずれか一項に記載の装置。
- 前記エンドエフェクタは、加熱素子又は電極、ガス又は液体などの加熱流体、低エネルギー超音波又は高強度集束超音波を含む超音波エネルギー、高調波エネルギー、直流又は焼灼にさらすこと、電磁エネルギー、高周波エネルギー、マイクロ波、プラズマエネルギー、赤外線、パルスレーザ、フラクショナルレーザ、又は高エネルギーレーザ露出を含むレーザ治療などの非電離光エネルギー、アルファ、ベータ、ガンマ、X線、プロトン、ニュートロン、又はイオン放射線を含む他の放射エネルギー、の形態でエネルギーを付与する、請求項1〜9のいずれか一項に記載の装置。
- 前記エネルギーは、前記エンドエフェクタの複数の電極を介して付与される、請求項1〜10のいずれか一項に記載の装置。
- 前記エネルギーの付与は、温度上昇をもたらし、前記温度は約65℃又はそれ以上である、請求項1〜11のいずれか一項に記載の装置。
- 前記エンドエフェクタは、ニチノールで構成されている、請求項1に記載の装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361905971P | 2013-11-19 | 2013-11-19 | |
US61/905,971 | 2013-11-19 | ||
PCT/US2014/065138 WO2015077093A1 (en) | 2013-11-19 | 2014-11-12 | Thoracoscopic methods for treatment of bronchial disease |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016538054A JP2016538054A (ja) | 2016-12-08 |
JP6529971B2 true JP6529971B2 (ja) | 2019-06-12 |
Family
ID=52004070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016532099A Expired - Fee Related JP6529971B2 (ja) | 2013-11-19 | 2014-11-12 | 気管支疾患の治療のための胸腔鏡検査方法 |
Country Status (10)
Country | Link |
---|---|
US (3) | US20150141810A1 (ja) |
EP (1) | EP3071134A1 (ja) |
JP (1) | JP6529971B2 (ja) |
KR (1) | KR20160088393A (ja) |
CN (2) | CN105744907A (ja) |
AU (2) | AU2014353275A1 (ja) |
CA (1) | CA2929660A1 (ja) |
IL (1) | IL245193B (ja) |
RU (1) | RU2016121165A (ja) |
WO (1) | WO2015077093A1 (ja) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10299773B2 (en) * | 2011-08-21 | 2019-05-28 | Transenterix Europe S.A.R.L. | Device and method for assisting laparoscopic surgery—rule based approach |
JP6529971B2 (ja) | 2013-11-19 | 2019-06-12 | エシコン・インコーポレイテッドEthicon, Inc. | 気管支疾患の治療のための胸腔鏡検査方法 |
CN106232044A (zh) * | 2014-02-21 | 2016-12-14 | 电路治疗公司 | 用于干咳的治疗控制的系统和方法 |
EP3154464A4 (en) * | 2014-06-12 | 2018-01-24 | Iowa Approach Inc. | Method and apparatus for rapid and selective tissue ablation with cooling |
EP3222238A4 (en) * | 2014-11-19 | 2018-07-11 | Kyushu University, National University Corporation | High-frequency forceps |
US10376308B2 (en) | 2015-02-05 | 2019-08-13 | Axon Therapies, Inc. | Devices and methods for treatment of heart failure by splanchnic nerve ablation |
EP3302264A4 (en) | 2015-06-03 | 2019-02-20 | Montefiore Medical Center | FOCUSED ULTRASOUND WITH LOW INTENSITY FOR THE TREATMENT OF CANCER AND METASTASES |
US10207110B1 (en) | 2015-10-13 | 2019-02-19 | Axon Therapies, Inc. | Devices and methods for treatment of heart failure via electrical modulation of a splanchnic nerve |
WO2018023132A1 (en) | 2016-07-29 | 2018-02-01 | Axon Therepies, Inc. | Devices, systems, and methods for treatment of heart failure by splanchnic nerve ablation |
US20190133681A1 (en) * | 2016-09-07 | 2019-05-09 | Chang Wook Jeong | Systems and methods for perivascular nerve denervation |
US11259859B2 (en) * | 2016-09-07 | 2022-03-01 | Deepqure Inc. | Systems and methods for renal denervation |
US20210085382A1 (en) * | 2016-09-07 | 2021-03-25 | Deepqure Inc. | Systems for perivascular nerve denervation |
DE102017118568B3 (de) * | 2017-08-15 | 2018-10-31 | Cinogy Gmbh | Plasma-Behandlungsgerät |
US10925628B2 (en) | 2017-09-18 | 2021-02-23 | Novuson Surgical, Inc. | Tissue engagement apparatus for theapeutic ultrasound apparatus and method |
JP2021502217A (ja) * | 2017-11-09 | 2021-01-28 | モンテフィオーレ メディカル センターMontefiore Medical Center | 癌および転移を処置するための低エネルギーの免疫刺激 |
US10561461B2 (en) | 2017-12-17 | 2020-02-18 | Axon Therapies, Inc. | Methods and devices for endovascular ablation of a splanchnic nerve |
EP3743147B1 (en) | 2018-01-26 | 2024-04-10 | Axon Therapies, Inc. | Device for endovascular ablation of a splanchnic nerve |
US11344356B2 (en) | 2018-02-28 | 2022-05-31 | Medtronic Cryocath Lp | Apparatus and method for targeted bronchial denervation by cryo-ablation |
JP7061788B2 (ja) * | 2018-03-26 | 2022-05-02 | 国立大学法人東京工業大学 | 組織の把持と組織へのプラズマ照射とを可能にするエンドエフェクタおよびそのエンドエフェクタを備える内視鏡システム |
WO2020257763A1 (en) | 2019-06-20 | 2020-12-24 | Axon Therapies, Inc. | Methods and devices for endovascular ablation of a splanchnic nerve |
WO2021033275A1 (ja) * | 2019-08-20 | 2021-02-25 | 株式会社Alivas | カテーテルデバイスおよび処置方法 |
WO2021146724A1 (en) | 2020-01-17 | 2021-07-22 | Axon Therapies, Inc. | Methods and devices for endovascular ablation of a splanchnic nerve |
US11666370B2 (en) | 2020-07-27 | 2023-06-06 | Medtronic, Inc. | Apparatus and method for targeted temporary bronchial nerve modulation by cryo-ablation for prevention and treatment of acute respiratory distress syndromes |
KR102244131B1 (ko) * | 2020-09-29 | 2021-04-23 | 주식회사 딥큐어 | 체내의 신경을 차단 또는 조절하기 위한 전극 장치 |
KR102583363B1 (ko) * | 2020-10-14 | 2023-10-18 | 인하대학교 산학협력단 | 내시경용 비가역적 전기천공법 장치 |
KR102296026B1 (ko) * | 2020-12-03 | 2021-09-02 | 주식회사 딥큐어 | 전극 장치 |
KR102296027B1 (ko) | 2021-02-10 | 2021-09-01 | 주식회사 딥큐어 | 체내의 신경을 차단 또는 조절하기 위한 전극 장치 |
KR102296024B1 (ko) * | 2021-04-01 | 2021-09-01 | 주식회사 딥큐어 | 체내의 신경을 차단 또는 조절하기 위한 전극 장치 |
EP4108197A1 (en) | 2021-06-24 | 2022-12-28 | Gradient Denervation Technologies | Systems for treating tissue |
EP4140424A1 (en) * | 2021-08-31 | 2023-03-01 | Medinice S.A. | A cryoprobe for minimally invasive cardiac ablation with a functional tip |
KR20240015185A (ko) * | 2022-07-26 | 2024-02-05 | 주식회사 딥큐어 | 체내의 신경을 차단 또는 조절하기 위한 전극 장치 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5865728A (en) * | 1991-05-29 | 1999-02-02 | Origin Medsystems, Inc. | Method of using an endoscopic inflatable lifting apparatus to create an anatomic working space |
US5361752A (en) | 1991-05-29 | 1994-11-08 | Origin Medsystems, Inc. | Retraction apparatus and methods for endoscopic surgery |
US5755714A (en) * | 1996-09-17 | 1998-05-26 | Eclipse Surgical Technologies, Inc. | Shaped catheter for transmyocardial revascularization |
US6634363B1 (en) | 1997-04-07 | 2003-10-21 | Broncus Technologies, Inc. | Methods of treating lungs having reversible obstructive pulmonary disease |
US5947984A (en) * | 1997-10-10 | 1999-09-07 | Ethicon Endo-Surger, Inc. | Ultrasonic clamp coagulator apparatus having force limiting clamping mechanism |
US7674259B2 (en) * | 2000-12-09 | 2010-03-09 | Tsunami Medtech | Medical instruments and techniques for thermally-mediated therapies |
US6527767B2 (en) * | 1998-05-20 | 2003-03-04 | New England Medical Center | Cardiac ablation system and method for treatment of cardiac arrhythmias and transmyocardial revascularization |
US8221402B2 (en) * | 2000-01-19 | 2012-07-17 | Medtronic, Inc. | Method for guiding a medical device |
US6692491B1 (en) * | 2000-03-24 | 2004-02-17 | Scimed Life Systems, Inc. | Surgical methods and apparatus for positioning a diagnostic or therapeutic element around one or more pulmonary veins or other body structures |
US9072522B2 (en) * | 2001-12-04 | 2015-07-07 | Atricure, Inc. | Adjustable clamp systems and methods |
US6932816B2 (en) * | 2002-02-19 | 2005-08-23 | Boston Scientific Scimed, Inc. | Apparatus for converting a clamp into an electrophysiology device |
US7083620B2 (en) * | 2002-10-30 | 2006-08-01 | Medtronic, Inc. | Electrosurgical hemostat |
US7149574B2 (en) | 2003-06-09 | 2006-12-12 | Palo Alto Investors | Treatment of conditions through electrical modulation of the autonomic nervous system |
EP1750608B1 (en) * | 2004-06-02 | 2012-10-03 | Medtronic, Inc. | Ablation device with jaws |
EP1750606B1 (en) * | 2004-06-02 | 2010-05-05 | Medtronic, Inc. | Compound bipolar ablation device |
US8876820B2 (en) * | 2004-10-20 | 2014-11-04 | Atricure, Inc. | Surgical clamp |
US7200445B1 (en) | 2005-10-21 | 2007-04-03 | Asthmatx, Inc. | Energy delivery devices and methods |
JP4755047B2 (ja) * | 2006-08-08 | 2011-08-24 | テルモ株式会社 | 作業機構及びマニピュレータ |
WO2008089360A1 (en) * | 2007-01-17 | 2008-07-24 | The Cleveland Clinic Foundation | Apparatus and methods for treating pulmonary conditions |
WO2009009444A1 (en) * | 2007-07-06 | 2009-01-15 | Barrx Medical, Inc. | Ablation in the gastrointestinal tract to achieve hemostasis and eradicate lesions with a propensity for bleeding |
US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
US8529563B2 (en) | 2008-08-25 | 2013-09-10 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
KR101722290B1 (ko) | 2009-10-27 | 2017-03-31 | 호라이라 인코포레이티드 | 냉각 가능한 에너지 에미팅 어셈블리를 갖는 전달 장치 |
EP4111995A1 (en) * | 2009-11-11 | 2023-01-04 | Nuvaira, Inc. | Device for treating tissue and controlling stenosis |
US8911439B2 (en) * | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
EP2555700B1 (en) | 2010-04-06 | 2015-06-03 | Holaira, Inc. | System for pulmonary treatment |
GB201100443D0 (en) | 2011-01-11 | 2011-02-23 | Creo Medical Ltd | Electrosurgical instrument |
US20130116683A1 (en) * | 2011-11-09 | 2013-05-09 | Tsunami Medtech, Llc | Medical system and method of use |
JP6022671B2 (ja) * | 2012-03-29 | 2016-11-09 | スパイレーション インコーポレイテッド ディー ビー エイ オリンパス レスピラトリー アメリカ | 肺組織の同定および処置のための装置、方法、およびシステム |
EP2854681A4 (en) * | 2012-06-01 | 2016-02-17 | Cibiem Inc | PERCUTANEOUS METHODS AND DEVICES FOR CAROTIDE BODY ABLATION |
US20140018788A1 (en) * | 2012-07-04 | 2014-01-16 | Zoar Jacob ENGELMAN | Devices and Systems for Carotid Body Ablation |
US9427251B2 (en) * | 2013-03-13 | 2016-08-30 | Covidien Lp | Saber tooth harvester |
JP6529971B2 (ja) | 2013-11-19 | 2019-06-12 | エシコン・インコーポレイテッドEthicon, Inc. | 気管支疾患の治療のための胸腔鏡検査方法 |
-
2014
- 2014-11-12 JP JP2016532099A patent/JP6529971B2/ja not_active Expired - Fee Related
- 2014-11-12 CA CA2929660A patent/CA2929660A1/en not_active Abandoned
- 2014-11-12 EP EP14806507.1A patent/EP3071134A1/en not_active Withdrawn
- 2014-11-12 US US14/538,930 patent/US20150141810A1/en not_active Abandoned
- 2014-11-12 CN CN201480063347.9A patent/CN105744907A/zh active Pending
- 2014-11-12 RU RU2016121165A patent/RU2016121165A/ru unknown
- 2014-11-12 AU AU2014353275A patent/AU2014353275A1/en not_active Abandoned
- 2014-11-12 CN CN201910884869.XA patent/CN110575244A/zh active Pending
- 2014-11-12 WO PCT/US2014/065138 patent/WO2015077093A1/en active Application Filing
- 2014-11-12 KR KR1020167016297A patent/KR20160088393A/ko not_active Application Discontinuation
-
2016
- 2016-04-19 IL IL245193A patent/IL245193B/en active IP Right Grant
-
2019
- 2019-07-30 US US16/526,245 patent/US11141214B2/en active Active
- 2019-08-06 AU AU2019213343A patent/AU2019213343A1/en not_active Abandoned
-
2021
- 2021-09-10 US US17/471,921 patent/US20210401488A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2015077093A1 (en) | 2015-05-28 |
EP3071134A1 (en) | 2016-09-28 |
US20200000514A1 (en) | 2020-01-02 |
US20150141810A1 (en) | 2015-05-21 |
CA2929660A1 (en) | 2015-05-28 |
JP2016538054A (ja) | 2016-12-08 |
AU2014353275A1 (en) | 2016-05-12 |
CN105744907A (zh) | 2016-07-06 |
IL245193B (en) | 2021-03-25 |
AU2019213343A1 (en) | 2019-08-29 |
RU2016121165A (ru) | 2017-12-25 |
US20210401488A1 (en) | 2021-12-30 |
KR20160088393A (ko) | 2016-07-25 |
IL245193A0 (en) | 2016-06-30 |
CN110575244A (zh) | 2019-12-17 |
US11141214B2 (en) | 2021-10-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6529971B2 (ja) | 気管支疾患の治療のための胸腔鏡検査方法 | |
US11969200B2 (en) | Eustachian tube modification | |
US9943361B2 (en) | Treating upper airway nerve tissue | |
US8753335B2 (en) | Therapeutic energy delivery device with rotational mechanism | |
US11304746B2 (en) | Method of treating airway tissue to reduce mucus secretion | |
CN106618731B (zh) | 用于处理组织和控制狭窄的系统、装置和方法 | |
WO2015153696A1 (en) | Post nasal drip treatment | |
CN108366828A (zh) | 用于人体粘膜组织的美容治疗的装置和方法 | |
JP6749339B2 (ja) | 高周波除神経ニードルおよび方法 | |
EP4355238A1 (en) | Electroporation treatment | |
US12042202B1 (en) | Pulsed field electroporation systems and methods | |
EP3125835B1 (en) | Post nasal drip treatment | |
WO2020252312A1 (en) | Cryotherapy systems and methods |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20170904 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20180725 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180731 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20181015 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20181127 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190218 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190416 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190515 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6529971 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |