JP6525223B2 - Biological information measuring device, biological information measuring method, and program - Google Patents

Description

  The present invention relates to a biological information measurement device, a biological information measurement method, and a program, and more particularly to a biological information measurement device that performs non-invasive blood pressure measurement, a biological information measurement method, and a program.

  IABP (Intra Aortic Balloon Pumping) is an auxiliary circulatory device widely used for left ventricular assist. The IABP places a balloon catheter in the descending aorta of the subject's chest, and provides pressure support for the heart by expanding / contracting the balloon in synchronization with the beating of the heart. This can increase the oxygen supply to the myocardium and reduce the oxygen consumption of the myocardium.

  For example, Patent Document 1 discloses an apparatus having a function for optimally setting IABP treatment timing.

Japanese Patent Publication No. 2007-503883 Patent No. 5229449 JP, 2012-40088, A

Takashi Usuda et al, “A Blood Pressure Monitor with Robust Noise Reduction System under Linear Cuff Inflation and Deflation”, Conf Proc IEEE Eng Med Biol Soc, 2010 [Search on June 30, 2014], Internet <URL: http://www.nihonkohden.co.jp/iryo/products/monitor/01_bedside/bsm1700.html>

  By the way, blood pressure values are vital signs important for grasping the condition of a subject. Therefore, it is preferable that the blood pressure value of the subject can be accurately grasped even when using IABP. Hereinafter, non-invasive blood pressure measurement (NIBP: Non Invasive Blood Pressure) will be examined.

  In non-invasive blood pressure measurement, a cuff (manshette) is wrapped around the upper arm or the like of a subject, and the air fed into the cuff compresses the upper arm and an artery passing therethrough. The pulsation (pulsation) of the compressed artery is transmitted to the cuff as vibration (oscillation), and the blood pressure value is calculated from the magnitude of the vibration. However, if the subject is using IABP, the blood pressure value calculated based on the balloon-assisted heart rate (systolic blood pressure (SYS), diastolic blood pressure (DIA), mean blood pressure (MAP: MEAN ATRERIAL PRESSURE)) It was not possible to distinguish whether the blood pressure values (systolic blood pressure (SYS), diastolic blood pressure (DIA), mean blood pressure (MAP)) calculated based on the subject-derived heart beat. As a result, there has been a problem that blood pressure values can not be acquired accurately.

  The present invention has been made in view of the above problems, and it is possible to calculate an accurate blood pressure value based on the blood volume circulated in the subject's body regardless of whether the subject uses IABP or not. A main object of the present invention is to provide a measuring device, a biological information measuring method, and a program.

One aspect of the biological information measurement device according to the present invention is
Beat information detection means for detecting heart beat information related to a subject's heart beat;
Pulse wave detection means for detecting a pulse wave during a period in which pressurization / decompression with a cuff is performed on a predetermined region of the subject;
The heart rate of the heart is detected from the heart rate information, the maximum value of the pulse wave in each one heart cycle is detected, and moving average processing is performed on each detected maximum value to derive the blood flow volume of the subject. Amplitude calculation means for calculating the amplitude value to be
And a blood pressure calculation unit that calculates a blood pressure value from the relationship between the amplitude value calculated by the amplitude calculation unit and the pressure applied by the cuff.

  When IABP is used and not used, the appearance of the pulse wave maximum value in one cardiac cycle is different. As described above, the biological information measurement device performs moving average processing on the maximum value of the pulse wave in one cardiac cycle, and calculates an amplitude value that accurately reflects the blood flow volume circulated in the body. The biological information measuring device can calculate a desired blood pressure value by using this amplitude value.

  The present invention relates to a biological information measuring apparatus, a biological information measuring method, and a program capable of calculating an accurate blood pressure value based on the volume of blood circulated in the body of a subject regardless of whether the subject uses IABP or not. Can be provided.

FIG. 1 is a block diagram showing a configuration of a biological information measurement device 1 according to a first embodiment. FIG. 1 is a block diagram showing a configuration of a biological information measurement device 1 according to a first embodiment. FIG. 1 is a block diagram showing a configuration of a biological information measurement device 1 according to a first embodiment. FIG. 6 is a conceptual view showing a relationship between cuff pressure and invasive blood pressure by the cuff 11 according to the first embodiment. FIG. 6 is a diagram showing a pulse wave detected by pulse wave detection means 21 according to the first embodiment. It is a figure which shows the relationship between an electrocardiogram (ECG) waveform and an oscillation waveform. It is a conceptual diagram (the assist ratio 1: 2 by IABP) which shows an oscillation waveform. FIG. 6 is a conceptual diagram showing calculation processing of each amplitude value according to the first embodiment. It is a conceptual diagram (the assist ratio 1: 1 by IABP) which shows an oscillation waveform. FIG. 6 is a conceptual diagram showing calculation processing of each amplitude value according to the first embodiment. FIG. 6 is a conceptual diagram showing the relationship between the oscillation table (data sequence) calculated by the amplitude calculation means 23 according to the first embodiment and the transition of the cuff pressure. FIG. 6 is a view showing an example of an output screen of the output means 16 according to the first embodiment. FIG. 7 is a diagram showing transition of each peak value according to the first embodiment.

Embodiment 1
Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a block diagram showing a configuration of a biological information measuring device 1 according to the present embodiment. The biological information measurement device 1 includes a cuff 11, a pressure sensor 12, a pump 13, an electromagnetic valve 14, an electrocardiogram electrode 15, an output unit 16, an input unit 17, and a control operation unit 20. The biological information measuring device 1 may be any device capable of measuring blood pressure non-invasively, and may be capable of acquiring each parameter other than blood pressure as in a biological information monitor. In the following description, it is assumed that the subject of the biological information measurement apparatus 1 may use IABP (Intra Aortic Balloon Pumping).

  The cuff 11 is mainly wound around the upper arm of the subject. Inside the cuff 11, an air bladder (not shown in FIG. 1) is provided for injecting air to compress the subject's artery. The pump 13 injects air into the air bladder in accordance with the control of the control calculation means 20. The solenoid valve 14 controls the exhaust of the air bladder in the cuff 11 in accordance with the control of the control calculation means 20.

  The pressure sensor 12 detects the air pressure in the cuff 11, that is, the cuff pressure. An A / D converter, an AC amplifier, various filters, and the like are appropriately provided downstream of the pressure sensor 12 (not shown in FIG. 1). An exemplary configuration between the pressure sensor 12 and the pulse wave detection means 21 is shown in FIGS. 2A and 2B. 2A and 2B, the description of the front stage configuration of the pressure sensor 12 and the rear stage configuration of the pulse wave detection means 21 will be omitted.

  FIG. 2A mainly shows a configuration example in the case of performing a filter by analog processing. The analog filter 31 subsequent to the pressure sensor 12 extracts an analog signal corresponding to the cuff pressure and an analog signal corresponding to the pulse wave by filtering. The A / D converter 32 converts an analog signal corresponding to the cuff pressure into a digital signal (cuff pressure signal) and supplies it to the pulse wave detection means 21. The analog filter 33 further filters the analog signal corresponding to the pulse wave. The A / D converter 34 converts the analog signal output from the analog filter 33 into a digital signal (pulse wave signal) and supplies the digital signal to the pulse wave detection means 21.

  FIG. 2B shows a configuration example in the case of performing filtering using digital processing. The analog signal output from the pressure sensor 12 is filtered by the analog filter 35 and input to the A / D converter 36. The A / D converter 36 converts the input analog signal into a digital signal and supplies the digital signal to the digital filter 25 in the control calculation means 20. The digital filter 25 performs digital filter processing, extracts a digital signal (cuff pressure signal) corresponding to the cuff pressure and a digital signal (pulse wave signal) corresponding to the pulse wave of the subject and supplies the pulse wave detection unit 21 . The configurations shown in FIGS. 2A and 2B are merely examples, and other configurations are possible as long as digital values corresponding to the cuff pressure and digital values corresponding to the pulse wave are supplied to the pulse wave detection means 21. It is also good.

  Refer back to FIG. The above-mentioned cuff 11, pressure sensor 12, pump 13, and solenoid valve 14 are the same as the general configuration used at the time of non-invasive blood pressure measurement.

  The electrocardiogram electrode 15 is composed of a plurality of electrodes (including seal electrodes and clip electrodes) attached to the chest, limbs and the like of the subject. The output unit 16 is a display provided on the housing of the biological information measurement apparatus 1, an internal printer, or the like. The input unit 17 is various input interfaces such as buttons and key panels provided on the housing of the biological information measurement apparatus 1. The output unit 16 and the input unit 17 may be integrated as in a touch display. As mentioned above, there are cases where the subject uses IABP.

  The control calculation means 20 controls the living body information measuring device 1. The control calculation means 20 includes a pulse wave detection means 21, an electrocardiogram measurement means 22, an amplitude calculation means 23, and a blood pressure calculation means 24. Furthermore, the control calculation means 20 includes a central processing unit (CPU), a read only memory (ROM), a random access memory (RAM), an input / output (I / O) port, a hard disk, etc. (not shown). Work in concert).

  The electrocardiogram measurement means 22 acquires an electrocardiogram (ECG: Electrocardiogram) based on the electrocardiogram signal obtained from the electrocardiogram electrode 15, and supplies the acquired electrocardiogram (ECG) to the amplitude calculation means 23. The operation and configuration of the electrocardiogram measurement means 22 may be the same as the function and operation of a general electrocardiogram measurement device.

  Before describing the operation of the pulse wave detection means 21, the relationship between the cuff pressure and the invasive blood pressure (which may not be acquired by the present apparatus) will be described with reference to FIG. In the example of FIG. 3, the IABP performs so-called 1: 2 assist (balloon assist in one cardiac cycle out of two cardiac cycles).

  As shown in the figure, during one cardiac cycle of two cardiac cycles, the point where the oscillation width (pulse wave pressure) is increased by IABP assistance, and the subject's own heart beat There exist both of the point where the oscillation width (pulse wave pressure) is high due to.

  The pulse wave detection means 21 is a pulse wave (hereinafter referred to as an oscillation) during a period in which the cuff 11 is performing pressure increase / decrease on the subject based on the cuff pressure signal (not shown) and the pulse wave signal (not shown). Also described as a waveform). FIG. 4 is a diagram showing an oscillation waveform ("OSC" in the figure) detected by the pulse wave detection means 21. As shown in FIG. The oscillation waveform shown in FIG. 4 corresponds to the change in cuff pressure and the invasive blood pressure shown in FIG. The pulse wave detection means 21 may also acquire the peak value (“height” in the figure) that can be acquired from the oscillation waveform. The pulse wave detection means 21 supplies information of the acquired pulse wave (information of oscillation waveform and peak value) and information of cuff pressure to the amplitude calculation means 23.

  The amplitude calculation means 23 includes information on pulse waves detected by the pulse wave detection means 21 (information on oscillation waveform and peak value), information on cuff pressure, and an electrocardiogram (ECG) acquired by the electrocardiogram measurement means 22. Supplied. The amplitude calculation means 23 detects a cardiac cycle of the subject's heart from heart rate information (in this example, an electrocardiogram (ECG)). Then, the amplitude calculation means 23 calculates an amplitude value derived from the heartbeat of the subject or an IABP-assisted amplitude value from the oscillation waveform in response to the detection of the maximum value of the oscillation waveform in one cardiac cycle. Details of the calculation process will be described below.

  FIG. 5 is a diagram showing the relationship between an electrocardiogram (ECG) waveform and an oscillation waveform. In the example of FIG. 5, the IABP performs so-called 1: 2 assist (balloon assist in one cardiac cycle out of two cardiac cycles). As shown, in the electrocardiogram (ECG), there is a QRS wave for each beat. The so-called RR interval corresponds to one cardiac cycle (one cardiac cycle). Treatment with the IABP reduces the balloon during systole of the subject's heart and dilates the balloon while closing the aortic valve. IABP balloon dilation / contraction is usually performed in synchronization with blood pressure (blood pressure waveform) or electrocardiogram (ECG).

  The amplitude calculating means 23 analyzes an electrocardiogram (ECG) waveform to detect a QRS wave, and acquires an interval of one heart of the heart. Then, the amplitude calculation means 23 cuts out an oscillation waveform of each cardiac cycle as shown in FIG. 5 on the basis of the minimum value of the oscillation waveform within a fixed time from the QRS wave.

  The amplitude calculating means 23 detects the maximum value of the oscillation waveform within each one cardiac cycle. Here, the maximum value is a peak point at which the amplitude value switches from rising to falling. With the exception of cases such as arrhythmia and Dicrotic Wave, one maximum value appears in one cardiac cycle in the case of a cardiac cycle without balloon assistance. In the case of a cardiac cycle with balloon assistance, two maxima appear in one cardiac cycle. The amplitude calculating means 23 does not treat a peak point (so-called noise or dicrotic wave) which repeats rising and falling of blood pressure values in a short time (within a predetermined time) as the maximum value. In addition, the amplitude calculation means 23 may perform filtering processing as pre-processing in order to exclude the influence of noise and the like. The amplitude calculation means 23 estimates the assist ratio of the IABP according to the detection condition of the maximum value (the number of times of detection of the maximum value in one cardiac cycle).

  The operation when the IABP mode is estimated to be 1: n (n is 2 or more) will be described with reference to FIGS. 6A and 6B. When it is estimated that the mode of IABP is 1: n (n is 2 or more), the amplitude calculating means 23 derives the first maximum value in one cardiac cycle in which two maximum values appear from the subject's heartbeat (subject's heart (Depending on the operation of (1)) (FIG. 6A). The amplitude calculation means 23 detects the second maximum value as an amplitude value assisted by IABP in one cardiac cycle in which two maximum values appear (FIG. 6B). In one cardiac cycle in which only one maximum value appears, the amplitude calculation means 23 detects the maximum value as an amplitude value derived from the subject's heartbeat (according to the subject's own heart operation) (FIG. 6A). Then, the amplitude calculating means 23 sequentially takes out an amplitude value derived from the heart beat of the subject and an amplitude value assisted by the IABP from each one cardiac cycle in order, and outputs an oscillation table (data string) indicating the relationship between elapsed time and change in amplitude value. Create (Figure 6B).

  The operation when the IABP mode is estimated to be 1: 1 will be described with reference to FIGS. 7A and 7B. When it is estimated that the IABP mode is 1: 1, the amplitude calculating means 23 detects the first maximum value in each cardiac cycle as the amplitude value derived from the subject's heartbeat (according to the subject's heart operation) (Figure 7A). The amplitude calculating means 23 detects the second maximum value in each one cardiac cycle as an amplitude value assisted by IABP (FIG. 7A). Then, the amplitude calculating means 23 sequentially takes out an amplitude value derived from the heart beat of the subject and an amplitude value assisted by the IABP from each one cardiac cycle in order, and outputs an oscillation table (data string) indicating the relationship between elapsed time and change in amplitude value. Create (Figure 7B).

  The amplitude calculating means 23 supplies the generated blood pressure calculating means 24 with the generated oscillation table (data row) (the amplitude value derived from the heart beat of the subject shown in FIG. 6B or 7B or the amplitude value assisted by IABP). When the doctor or the like specifies that the blood pressure value based on the amplitude value derived from the subject's heartbeat is output using the input unit 17, the amplitude calculation unit 23 generates an oscillation table related to the amplitude value derived from the subject's heart Only data strings may be output. The same applies to the case where the doctor or the like specifies that the blood pressure value assisted by IABP is output.

  The amplitude calculating means 23 also supplies the blood pressure calculating means 24 with the information on the cuff pressure inputted from the pulse wave detecting means 21.

  The user (such as a doctor) of the biological information measurement device 1 may explicitly input mode information indicating whether or not the IABP is in use to the biological information measurement device 1. In this case, the doctor or the like operates the input unit 17 to input mode information. Here, the mode information preferably includes information on IABP assist ratio. For example, when 1: 3 is input as an assist ratio, the amplitude calculation means 23 calculates so that only one maximum value is detected in the following two cardiac cycles when two maximum values are detected in one cardiac cycle. Do. Thus, by explicitly inputting the assist ratio, the amplitude calculation means 23 can calculate each amplitude value more appropriately (in other words, without performing erroneous detection).

  In addition, when two maximum values are detected within one cardiac cycle, the amplitude calculation means 23 calculates the time between the detection timing of the first maximum value and the calculation timing of the second maximum value as well. It is also good. In this case, the amplitude calculating means 23 calculates the difference between this calculation time (the time between the detection timing of the first maximum value and the detection timing of the second maximum value, the long dashed line in FIG. 6A) and the predetermined time. Determine if it is within a certain range. Here, the predetermined time is a desired (high therapeutic effect) time from autosystolic pressure to augmentation pressure in IABP treatment. Therefore, when the above difference is not within the predetermined range, the amplitude calculating unit 23 may have a function of determining that the IABP treatment timing (the operation timing of the balloon) is not appropriate and notifying the user.

  The blood pressure calculation means 24 calculates a desired blood pressure value from the relationship between the amplitude value calculated by the amplitude calculation means 23 (that is, the above-mentioned oscillation table (FIG. 6B and FIG. 7B)) and the transition of the applied pressure of the cuff 11. Do. The details of the blood pressure value calculation method will be described with reference to FIG.

  FIG. 8 is a conceptual diagram showing the relationship between the oscillation table (data sequence) calculated by the amplitude calculation means 23 and the transition of the cuff pressure. Here, the oscillation table (data sequence) corresponds to the output mode (output mode of blood pressure value derived from the subject's heartbeat, output mode of blood pressure value assisted by IABP, output mode of both blood pressure values) specified by a doctor etc. Be subject to In the example of FIG. 8, it is assumed that the doctor or the like selects the output mode of the blood pressure value derived from the subject's heart beat, so the oscillation table (from the subject's heart beat) derived from the subject's heart beat ( It is targeted at data string).

  The blood pressure calculation means 24 calculates a cuff pressure value corresponding to the maximum value of the amplitude as an average blood pressure (MAP). Alternatively, the mean blood pressure (MAP) may be determined by any process such as interpolation. In the example of FIG. 8, since the cuff pressure corresponding to the maximum amplitude value is 90 mmHg in the example of FIG. 8, the blood pressure computing unit 24 calculates the average blood pressure (MAP) as 90 mmHg. The blood pressure calculation means 24 calculates systolic blood pressure (SYS) and diastolic blood pressure (DIA) from the cuff pressure corresponding to the amplitude value of 50% of the maximum amplitude value. In the example of FIG. 8, the blood pressure calculation means 24 calculates the systolic blood pressure (SYS) as 110 mmHg and the diastolic blood pressure (DIA) as 70 mmHg.

  The details of the blood pressure calculation method using an oscillation table (data sequence) are described, for example, in FIG. Please refer to 1 grade. Note that the above-described blood pressure calculation method is an example using an oscillation table (data sequence) by the oscillometric method, and it is needless to say that another method may be used. In the above description, systolic blood pressure (SYS) and diastolic blood pressure (DIA) are calculated based on 50% of the maximum amplitude value, but this 50% is merely an example.

  The blood pressure calculation means 24 outputs the calculated blood pressure values via the output means 16. FIG. 9 is a conceptual diagram showing an output example. As shown in FIG. 9, the blood pressure calculation means 24 combines, for example, an output mode and each blood pressure value and outputs (for example, printing on paper or displaying on a display provided on the housing of the biological information measuring device 1). The screen example in FIG. 9 is merely an example, and each blood pressure value may be displayed together with the pulse wave and the electrocardiogram waveform.

(Modification)
As a modification, a method of calculating a blood pressure value focusing on the blood flow volume circulating in the subject's body will be described. In the above description, although the blood pressure value derived from the subject's heart rate or the blood pressure value assisted by the IABP is calculated, the following example is assisted by the beat derived from the subject's heart rate and IABP A method of measuring a blood pressure value in consideration of both of the beats will be described.

  The processes of the pulse wave detection means 21 and the electrocardiogram measurement means 22 are the same as described above. The amplitude calculation means 23 detects the maximum value in each one cardiac cycle from the oscillation waveform by the above-mentioned method, and obtains a moving average (for example, three-point moving average, five-point moving average) of each detected maximum value. That is, the amplitude calculating means 23 calculates the amplitude value derived from the blood flow by moving average based on both the amplitude value derived from the heart beat of the subject and the amplitude value assisted by IABP (amplitude value derived from the blood flow circulating in the subject's body) Calculate). Then, the amplitude calculation means 23 creates an oscillation table (data sequence) using the amplitude value obtained by the moving average. The method of generating the oscillation table (data string) is the same as that of FIG. 6 (B) or FIG. 7 (B).

  The moving average is more preferably a calculation taking into consideration the IABP assist ratio. For example, it is preferable to perform three-point moving average when the IABP assist ratio is 1: 3 and perform five-point moving average when the assist ratio is 1: 5. That is, it is desirable that the amplitude calculation means 23 perform an averaging process using the number of data corresponding to the IABP assist ratio. For example, in the case where the 5-point averaging process is performed for an assist ratio of 1: 3, there are cases where the averaging process is performed by including two pieces of data assisted by IABP with respect to the number of five data. Similarly, there is a case where only one IABP-assisted data is included for five data numbers and averaging is performed. In any case, the accuracy of the calculated blood pressure value is slightly deteriorated. However, by making the assist ratio correspond to the number of processing data of the averaging process, the timing of the IABP is accurately reflected, and it becomes possible to calculate a more accurate blood pressure value. Here, to associate the assist ratio with the processing data number of the averaging process is not limited to the case where the averaging process is performed using three pieces of data when the assist ratio is 1: 3, but data of the number of multiples of three The concept is also included in the case of performing averaging processing using. Further, the control calculation means 20 may perform the moving average by applying the method described in Patent Document 2 by the present inventor. The processing after creating the oscillation table (data string) is the same as the above-described method.

  When the blood pressure value is calculated based on the amplitude value obtained by the moving average of the maximum value as described above, the blood pressure value reflecting the blood flow volume circulated in the body of the subject regardless of whether or not IABP assist is performed I can understand.

  The amplitude calculation means 23 can also perform the same processing using the peak value ("height" in FIG. 4). FIG. 10 is a view showing the peak values (identical to FIG. 4) when the assist ratio is 1: 2, and various peak values. As shown in the figure, the crest value (transition of the crest value surrounded by a square in the figure) obtained from the oscillation waveform alternately appears a crest value derived from the subject's heartbeat and a crest value subjected to IABP assistance. Therefore, the above-described detection processing of the amplitude value derived from the heartbeat of the subject (the first maximum value is detected as the amplitude value derived from the heartbeat of the subject within one cardiac cycle) connects the lower peak values of this peak value. Corresponds to the peak value transition (dotted line in the figure) that can be The peak values (dotted line portion in FIG. 10) derived from the heartbeat of the subject and the oscillation tables (data strings) shown in FIG. 8 and the like have correspondence relationships because they are generated based on the same oscillation waveform. Therefore, the amplitude calculating means 23 can also calculate each blood pressure value derived from the heart beat of the subject based on the transition of the peak value.

  Here, the amplitude calculating means 23 may calculate each blood pressure value using a moving average of the peak value (three-point moving average, five-point moving average in the example of FIG. 10). In this case, the amplitude value derived from the subject's heartbeat and the amplitude value assisted by the IABP are averaged and handled. The amplitude calculating means 23 can calculate each blood pressure value according to the blood flow volume within a predetermined time by performing calculation processing based on the crest value obtained by the moving average.

  Then, the effect of living body information measuring device 1 concerning this embodiment is explained. As described above, the biological information measurement device 1 derives from the subject's heartbeat according to the detection state of the pulse wave maximum value (whether two maximum values exist or not, detected amplitude value) within one cardiac cycle. And at least one of the amplitude value assisted by the IABP and the amplitude value when attention is paid to the blood flow volume. The biological information measuring device 1 can calculate a desired blood pressure value based on these amplitude values. For example, when it is desired to refer to the blood pressure value derived from the subject's heartbeat (blood pressure value corresponding to the beat of the subject's heart), the biological information measuring device 1 calculates the blood pressure value using the amplitude value derived from the subject's heartbeat. A doctor or the like can easily determine the therapeutic effect of IABP, withdrawal of IABP, etc. by referring to the blood pressure value derived from the beating of the subject's heart.

  The biological information measuring device 1 detects one cardiac cycle based on the detection timing of the QRS wave of the electrocardiogram. The R wave of the electrocardiogram is a point where the voltage change is large. Therefore, the biological information measurement device 1 can calculate one cardiac cycle with high accuracy by using the R wave as a reference, and can calculate the blood pressure value with high accuracy.

  As described above, the amplitude calculation means 23 detects the first maximum value as an amplitude value derived from the subject's heartbeat (according to the subject's heart operation) in one cardiac cycle in which two maximum values appear (see FIG. 6A). The amplitude calculating means 23 detects the second maximum value as an amplitude value assisted by IABP in one cardiac cycle in which two maximum values appear (FIG. 6B). There is no individual difference in the detection timing of this maximum value (twice in one cardiac cycle when using IABP and once in the trial period when IABP is not used), so blood pressure with a certain level of performance for any subject The value can be calculated.

  Preferably, the amplitude calculating means 23 calculates each blood pressure value using explicitly designated mode information (whether or not IABP is used and information of assist ratio). Since the assist ratio can be recognized in advance, the amplitude calculation means 23 can assume at which timing two maximum values appear in one cardiac cycle. As a result, the amplitude calculating means 23 can greatly reduce the possibility of erroneous detection of the amplitude value.

  As mentioned above, although the invention made by the present inventor was concretely explained based on an embodiment, the present invention is not limited to the embodiment mentioned already, A various change in the range which does not deviate from the gist It goes without saying that it is possible.

  For example, in the above description (FIG. 8 and the like), an oscillometric method is assumed in which pressure is reduced after pressure is applied to the cuff 11 to a certain value, but this is not necessarily the case. That is, the biological information measurement device 1 may use a technique (for example, Patent Document 3 and Non-Patent Document 2) of measuring non-invasive blood pressure (NIBP) at the time of pressurization. Even in this case, by using the above-described algorithm (algorithm using detection of the maximum value), even when using IABP, a desired blood pressure value (blood pressure value derived from the subject's heart rate, IABP assisted blood pressure value) The blood pressure value derived from the blood flow of the subject can be accurately acquired.

  In the above-mentioned example, although one cardiac cycle was calculated using an electrocardiogram (ECG), it is not necessarily restricted to this. The electrocardiogram (ECG) is used to acquire information (heart rate information) related to the heart beat (heart rate). Therefore, any configuration other than the electrocardiogram measurement means 22 may be adopted as long as it is a configuration capable of acquiring heartbeat information related to the heartbeat of the subject. For example, a pulse wave due to SpO 2 may be detected, one cardiac cycle may be estimated from the pulse wave, and the above-described processing may be performed. That is, the living body information measuring device 1 may have any configuration as long as it has a pulsation information detecting means for acquiring heartbeat information of the subject (electrocardiogram in the example of FIG. 1), and the electrocardiogram measuring means 22 is an aspect of the pulsation information detecting means .

  Further, each process in the control calculation means 20 described above can be realized as a computer program that operates in the biological information measuring device 1. That is, it is assumed that the biological information measurement device 1 also includes a configuration of a central processing unit (CPU) and a memory device included in a general computer.

  The programs can be stored and provided to a computer using various types of non-transitory computer readable media. Non-transitory computer readable media include tangible storage media of various types. Examples of non-transitory computer readable media are magnetic recording media (eg flexible disk, magnetic tape, hard disk drive), magneto-optical recording media (eg magneto-optical disk), CD-ROM (Read Only Memory), CD-R, CD-R / W, semiconductor memory (for example, mask ROM, PROM (Programmable ROM), EPROM (Erasable PROM), flash ROM, RAM (random access memory)) are included. Also, the programs may be supplied to the computer by various types of transitory computer readable media. Examples of temporary computer readable media include electrical signals, light signals, and electromagnetic waves. The temporary computer readable medium can provide the program to the computer via a wired communication path such as electric wire and optical fiber, or a wireless communication path.

DESCRIPTION OF SYMBOLS 1 biological information measuring apparatus 11 cuff 12 pressure sensor 13 pump 14 electromagnetic valve 15 electrocardiogram electrode 16 output means 17 input means 20 control calculating means 21 pulse wave detecting means 22 electrocardiogram measuring means 23 amplitude calculating means 24 blood pressure calculating means 25 digital filter 31, 33, 35 analog filters 32, 34, 36 A / D converters

Claims (4)

Beat information detection means for detecting heart beat information related to a subject's heart beat;
Pulse wave detection means for detecting a pulse wave during a period in which pressurization / decompression with a cuff is performed on a predetermined region of the subject;
The heart rate of the heart is detected from the heart rate information, the maximum value of the pulse wave in each one heart cycle is detected, and moving average processing is performed on each detected maximum value to derive the blood flow volume of the subject. Amplitude calculation means for calculating the amplitude value to be
Blood pressure calculation means for calculating a blood pressure value from the relationship between the amplitude value calculated by the amplitude calculation means and the pressure applied by the cuff;
Equipped with
The said amplitude calculation means performs a moving average process using the number of data corresponding to the assist ratio of IABP . The heart rate information is an electrocardiogram,
The biological information measuring apparatus according to claim 1 , wherein the amplitude calculation means detects a QRS wave from the electrocardiogram and performs calculation processing of each amplitude value on the basis of a detection point of the QRS wave. A beat information detection step of detecting heart beat information on a subject's heart beat;
A pulse wave detection step of detecting a pulse wave during a period in which pressurization and depressurization with a cuff is performed on a predetermined site of the subject;
The heart rate of the heart is detected from the heart rate information, the maximum value of the pulse wave in each one heart cycle is detected, and moving average processing is performed on each detected maximum value to derive the blood flow volume of the subject. Calculating an amplitude value to be calculated;
A blood pressure calculation step of calculating a blood pressure value from the relationship between the amplitude value calculated in the amplitude calculation step and the pressurizing force of the cuff;
Equipped with
The biological information measuring method , wherein moving average processing is performed using the number of data corresponding to the IABP assist ratio in the amplitude calculation step . On the computer
A beat information detection step of detecting heart beat information on a subject's heart beat;
A pulse wave detection step of detecting a pulse wave during a period in which pressurization and depressurization with a cuff is performed on a predetermined site of the subject;
The heart rate of the heart is detected from the heart rate information, the maximum value of the pulse wave in each one heart cycle is detected, and moving average processing is performed on each detected maximum value to derive the blood flow volume of the subject. Calculating an amplitude value to be calculated;
A blood pressure calculation step of calculating a blood pressure value from the relationship between the amplitude value calculated in the amplitude calculation step and the pressurizing force of the cuff;
A program to be executed by the,
In the amplitude calculating step, moving average processing is performed using the number of data corresponding to the IABP assist ratio.

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