JP6502387B6 - 細菌感染の治療のための融合スピロ環ヘテロ芳香族化合物 - Google Patents
細菌感染の治療のための融合スピロ環ヘテロ芳香族化合物 Download PDFInfo
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- JP6502387B6 JP6502387B6 JP2016568934A JP2016568934A JP6502387B6 JP 6502387 B6 JP6502387 B6 JP 6502387B6 JP 2016568934 A JP2016568934 A JP 2016568934A JP 2016568934 A JP2016568934 A JP 2016568934A JP 6502387 B6 JP6502387 B6 JP 6502387B6
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- ureaplasma
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- LJVAJPDWBABPEJ-PNUFFHFMSA-N telithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]([C@]2(OC(=O)N(CCCCN3C=C(N=C3)C=3C=NC=CC=3)[C@@H]2[C@@H](C)C(=O)[C@H](C)C[C@@]1(C)OC)C)CC)[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O LJVAJPDWBABPEJ-PNUFFHFMSA-N 0.000 description 1
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- 238000012546 transfer Methods 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
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- LQCLVBQBTUVCEQ-QTFUVMRISA-N troleandomycin Chemical compound O1[C@@H](C)[C@H](OC(C)=O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(C)=O)[C@H]1C LQCLVBQBTUVCEQ-QTFUVMRISA-N 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201462004246P | 2014-05-29 | 2014-05-29 | |
| US62/004,246 | 2014-05-29 | ||
| PCT/IB2015/001585 WO2015181637A1 (en) | 2014-05-29 | 2015-05-27 | Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections |
Publications (4)
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| JP2017516777A JP2017516777A (ja) | 2017-06-22 |
| JP2017516777A5 JP2017516777A5 (https=) | 2018-06-07 |
| JP6502387B2 JP6502387B2 (ja) | 2019-04-17 |
| JP6502387B6 true JP6502387B6 (ja) | 2019-05-29 |
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| JP2016568934A Expired - Fee Related JP6502387B6 (ja) | 2014-05-29 | 2015-05-27 | 細菌感染の治療のための融合スピロ環ヘテロ芳香族化合物 |
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| Country | Link |
|---|---|
| US (1) | US10238661B2 (https=) |
| EP (1) | EP3148546A1 (https=) |
| JP (1) | JP6502387B6 (https=) |
| KR (1) | KR20170007818A (https=) |
| CN (1) | CN106659725A (https=) |
| AU (1) | AU2015265620B2 (https=) |
| CA (1) | CA2948438A1 (https=) |
| EA (1) | EA033459B1 (https=) |
| IL (1) | IL248838B (https=) |
| MX (1) | MX365261B (https=) |
| PH (1) | PH12016502271B1 (https=) |
| SG (2) | SG10201906842WA (https=) |
| TW (1) | TWI657818B (https=) |
| WO (1) | WO2015181637A1 (https=) |
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| CN109111465B (zh) * | 2017-06-22 | 2021-01-12 | 中国科学院上海药物研究所 | 噻唑烷酮螺嘧啶三酮类化合物及制备方法和用途 |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| EP3833665B1 (en) | 2018-08-09 | 2023-07-19 | Antabio SAS | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
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| US7208490B2 (en) | 2002-10-07 | 2007-04-24 | Pharmacia & Upjohn Company Llc | Tricyclic tetrahydroquinoline antibacterial agents |
| JP2007502307A (ja) | 2003-08-15 | 2007-02-08 | アストラゼネカ アクチボラグ | グルタミン酸ラセマーゼ（ｍｕｒｉ）の阻害剤としての縮合複素環 |
| CA2606847A1 (en) | 2005-05-09 | 2006-11-16 | Warner-Lambert Company Llc | Antibacterial agents |
| DOP2006000268A (es) | 2005-12-22 | 2007-07-31 | Pfizer Prod Inc | Agentes antibacterianos |
| CL2007003332A1 (es) | 2006-11-24 | 2008-06-20 | Actelion Pharmaceuticals Ltd | Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas. |
| US20100261719A1 (en) | 2007-07-02 | 2010-10-14 | Gregory Steven Basarab | Chemical compounds |
| US9040528B2 (en) | 2008-10-14 | 2015-05-26 | Astrazeneca Ab | Chemical compounds 542 |
| CN102245605B (zh) * | 2008-10-14 | 2016-01-27 | 阿斯利康(瑞典)有限公司 | 用于治疗细菌感染的稠合、螺环杂芳族化合物 |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| US8952149B2 (en) | 2012-09-26 | 2015-02-10 | Zoetis Llc | Tricyclic tetrahydroquinoline antibacterial agents |
| US8889671B2 (en) | 2013-01-23 | 2014-11-18 | Astrazeneca Ab | Compounds and methods for treating bacterial infections |
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2015
- 2015-05-27 SG SG10201906842WA patent/SG10201906842WA/en unknown
- 2015-05-27 CN CN201580027395.7A patent/CN106659725A/zh active Pending
- 2015-05-27 EP EP15781402.1A patent/EP3148546A1/en not_active Withdrawn
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| IL248838B (en) | 2020-05-31 |
| TW201607537A (zh) | 2016-03-01 |
| TWI657818B (zh) | 2019-05-01 |
| US20180169104A1 (en) | 2018-06-21 |
| EA201692250A1 (ru) | 2017-06-30 |
| EP3148546A1 (en) | 2017-04-05 |
| PH12016502271A1 (en) | 2017-02-06 |
| JP6502387B2 (ja) | 2019-04-17 |
| JP2017516777A (ja) | 2017-06-22 |
| IL248838A0 (en) | 2017-01-31 |
| SG10201906842WA (en) | 2019-08-27 |
| US10238661B2 (en) | 2019-03-26 |
| EA033459B1 (ru) | 2019-10-31 |
| AU2015265620A1 (en) | 2016-11-24 |
| WO2015181637A1 (en) | 2015-12-03 |
| MX365261B (es) | 2019-05-27 |
| PH12016502271B1 (en) | 2017-02-06 |
| KR20170007818A (ko) | 2017-01-20 |
| MX2016015632A (es) | 2017-04-25 |
| AU2015265620B2 (en) | 2020-04-09 |
| SG11201609404SA (en) | 2016-12-29 |
| CN106659725A (zh) | 2017-05-10 |
| CA2948438A1 (en) | 2015-12-03 |
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