JP6499157B2 - 新規のα４β７ペプチド二量体アンタゴニスト - Google Patents
新規のα４β７ペプチド二量体アンタゴニスト Download PDFInfo
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- JP6499157B2 JP6499157B2 JP2016506352A JP2016506352A JP6499157B2 JP 6499157 B2 JP6499157 B2 JP 6499157B2 JP 2016506352 A JP2016506352 A JP 2016506352A JP 2016506352 A JP2016506352 A JP 2016506352A JP 6499157 B2 JP6499157 B2 JP 6499157B2
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| US14/229,784 US20140294901A1 (en) | 2013-04-02 | 2014-03-28 | Novel a4b7 peptide dimer antagonists |
| US14/229,784 | 2014-03-28 | ||
| PCT/US2014/032391 WO2014165448A1 (en) | 2013-04-02 | 2014-03-31 | NOVEL α4β7 PEPTIDE DIMER ANTAGONISTS |
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| US9273093B2 (en) | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
| AU2014232954B2 (en) | 2013-03-15 | 2018-08-09 | Protagonist Therapeutics, Inc. | Hepcidin analogues and uses therof |
| ES2890600T3 (es) | 2014-05-16 | 2022-01-20 | Protagonist Therapeutics Inc | Péptidos de tioéter antagonistas de integrina alfa4beta7 |
| CN107206254B (zh) | 2014-07-17 | 2021-08-24 | 领导医疗有限公司 | 白细胞介素-23受体的口服肽抑制剂以及其治疗炎症性肠病的用途 |
| CA2962642A1 (en) | 2014-10-01 | 2016-04-07 | Protagonist Therapeutics, Inc. | Novel .alpha.4.beta.7 peptide monomer and dimer antagonists |
| US10301371B2 (en) | 2014-10-01 | 2019-05-28 | Protagonist Therapeutics, Inc. | Cyclic monomer and dimer peptides having integrin antagonist activity |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| EP3365353B1 (en) * | 2015-10-23 | 2023-11-22 | Universiteit Twente | Integrin binding peptides and uses thereof |
| US20190002503A1 (en) | 2015-12-30 | 2019-01-03 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| US10407468B2 (en) | 2016-03-23 | 2019-09-10 | Protagonist Therapeutics, Inc. | Methods for synthesizing α4β7 peptide antagonists |
| EP3681900A4 (en) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
| EP4501952A3 (en) | 2018-02-08 | 2025-04-16 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| CN116082455A (zh) | 2019-07-10 | 2023-05-09 | 领导医疗有限公司 | 白细胞介素-23受体的肽抑制剂及其用于治疗炎症性疾病的用途 |
| MA58373B1 (fr) | 2020-01-15 | 2025-07-31 | Janssen Biotech, Inc. | Inhibiteurs peptidiques du récepteur de l'interleukine-23 et leur utilisation pour traiter des maladies inflammatoires |
| WO2021146454A1 (en) | 2020-01-15 | 2021-07-22 | Janssen Biotech, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| MX2023005994A (es) | 2020-11-20 | 2023-08-11 | Janssen Pharmaceutica Nv | Composiciones de inhibidores peptidicos del receptor de interleucina-23. |
| EP4370146A4 (en) | 2021-07-14 | 2025-05-21 | Janssen Biotech, Inc. | Lipidated peptide inhibitors of the interleukin-23 receptor |
| CN114874107B (zh) * | 2022-07-12 | 2022-11-29 | 中山大学附属第七医院(深圳) | 一种氨基脂质及其制备方法和应用 |
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| US6037324A (en) * | 1996-01-04 | 2000-03-14 | Leukosite, Inc. | Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor |
| GB9613112D0 (en) * | 1996-06-21 | 1996-08-28 | Zeneca Ltd | Chemical compounds |
| US6818617B1 (en) * | 1997-08-15 | 2004-11-16 | Temple University- Of The Commonwealth System Of Higher Education | EC-3, an inhibitor of α4β1 and α4β7 integrins |
| WO1999026615A1 (en) * | 1997-11-24 | 1999-06-03 | Merck & Co., Inc. | Cyclic amino acid derivatives as cell adhesion inhibitors |
| RU2292904C2 (ru) * | 2001-01-09 | 2007-02-10 | Мерк Патент Гмбх | Комбинированная терапия, использующая ингибиторы рецептора тирозинкиназы и ингибиторы ангиогенезиса |
| GB0610395D0 (en) * | 2006-05-25 | 2006-07-05 | Ge Healthcare Ltd | Novel imaging agents |
| EP2109480B1 (en) * | 2006-12-07 | 2017-06-28 | The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services | Use of antagonists of the interaction between hiv gp120 and alpha4beta7 integrin |
| WO2009039185A1 (en) * | 2007-09-17 | 2009-03-26 | The Trustees Of Columbia University In The City Of New York | Uses of immunologically modified scaffold for tissue prevascularization and cell transplantation |
| JP2011231085A (ja) * | 2010-04-30 | 2011-11-17 | Osaka Prefecture Univ | 環状ペプチド |
| EP2444101A1 (en) * | 2010-10-21 | 2012-04-25 | Universitätsklinikum Freiburg | Selective targeting of the CD40L/Mac-1 interaction by small peptide inhibitors and its use for the treatment of inflammation and atherogenesis |
| US9273093B2 (en) * | 2012-10-11 | 2016-03-01 | Protagonist Therapeutics, Inc. | α4β7 peptide dimer antagonists |
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| CN105339383A (zh) | 2016-02-17 |
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| HK1221233A1 (zh) | 2017-05-26 |
| EP2981544A1 (en) | 2016-02-10 |
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