JP6483655B2 - 細胞注入針 - Google Patents
細胞注入針 Download PDFInfo
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- JP6483655B2 JP6483655B2 JP2016500811A JP2016500811A JP6483655B2 JP 6483655 B2 JP6483655 B2 JP 6483655B2 JP 2016500811 A JP2016500811 A JP 2016500811A JP 2016500811 A JP2016500811 A JP 2016500811A JP 6483655 B2 JP6483655 B2 JP 6483655B2
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
- A61M5/1582—Double lumen needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/0069—Tip not integral with tube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
Description
細胞送達に先立って、使用者(例えば医師又は他の医学専門家)は細胞のための送達部位を選択する。例えば、患者が心臓発作を患っているのであれば施術者は梗塞帯域又はその付近の場所を選定することになろう。腹圧性尿失禁を患う患者については、施術者は横紋筋性括約筋(rhabdosphincter)又はその付近に標的場所を選定することになろう。
102 シリンジ
104 中空針
106 接続部分
108 第1操作部材
110 第2操作部材
112 プライミング部分
200 細胞送達システム
202 シリンジ
204 中空針
206 接続部材
208 第1操作部材
210 第2操作部材
212 プライミング部分
300 壁
302 中央ルーメン
304 先端制御部材
402 制御ルーメン
404 流体送達ルーメン
500 患者の身体
600 針
602 シース部分
604 中心キャリア部分
606 内面
608 空洞部
610 キャリアシャフト
612 ノーズ部分
614 連結部分
616 連結面
618 組織穿通部分
620 組織分離部分
622 プライミング部分
624 リップ又は縁部
626 長手方向軸線
800 針
802 シース部分
804 中心キャリア部分
806 内面
808 空洞部
810 キャリアシャフト
812 端領域
814 遠位領域
816 接点
818 組織穿通遠位先端
820 組織分離部分
822 プライミング部分
824 追従縁
826 長手方向軸線
1400 針
1402 本体部分
1406 内面
1408 空洞部
1412 ノーズ部分
1414 面
1422 孔又はポート
1424 開口
1426 空洞部
1428 ストッパ部材
1430 捕捉部材
1600 針
1602 シース部分
1606 内面
1608 空洞部
1612 ノーズ部分
1622 ポート又は孔
1800 針
1802 シース部分
1806 内面
1808 第1空洞部
1810 中空シャフト部分
1811 第2空洞部
1814 放出領域
1822 シース部分のポート又は孔
1824 シャフト部分の孔
1826 長手方向軸線
2000 針
2002 シース部分
2004 中心キャリア部分
2006 内面
2007 外面
2008 第1空洞部
2009 第2空洞部
2010 シャフト部分
2011 シャフト空洞部
2022 プライミング部分
2024 孔
2032 シール
Claims (11)
- 細胞送達システムであって、
長手方向軸線に沿って延びる第1部分と、前記長手方向軸線に沿って延びる第2部分と、を備え、組織穿通に適合されている遠位先端で終端している細長い針本体、を備えており、
前記第1部分は前記長手方向軸線に沿って伸びる空洞部と開口した遠位端を画定するシース部分を有し、前記第2部分は前記シース部分内を前記長手方向軸線に沿って延びるシャフト部分と該シャフト部分の遠位に配置された遠位部分とを有し、前記遠位部分は前記シャフト部分の直径よりも大きくされて前記遠位先端を形成するようにされており、
前記針本体は、組織内への刺入のための第1形態から、前記第2部分を前記第1部分に対して遠位方向に変位させることにより、前記針本体の一部分が療法の所望される組織場所に隣接したときに細胞を送達するための第2形態へ移行でき、
前記針本体が前記第1形態にあるときには、前記第2部分の前記遠位部分が、前記シース部分の前記開口した遠位端を封止して前記シース部分の内周面と前記シャフト部分の外周面との間の前記空洞部に複数の細胞を保持し、前記遠位部分から前記シース部分の外面にかけて連続する滑らかな移行部が形成されるようになっており、
前記針本体が前記第2形態にあるときには、前記遠位部分が前記開口した遠位端から遠位に延びて、前記シース部分の前記開口した遠位端が開放されて前記空洞部内に保持されている細胞が療法の所望される組織場所に向けて送達されるようにされた、システム。 - 前記空洞部と流体連通しているルーメンを更に備えている、請求項1に記載のシステム。
- 前記第1部分と前記第2部分の一方又は両方が、前記第1形態から前記第2形態へ移行する際に前記長手方向軸線に沿って動く、請求項1又は請求項2に記載のシステム。
- 組織を穿通する前記遠位先端に隣接するプライミング部分を更に備えており、
前記プライミング部分は、当該プライミング部分に隣接する組織に、前記空洞部から前記組織への細胞到着に先立って治癒応答又は再生応答を生成するように配設されている、請求項1から請求項3の何れか一項に記載のシステム。 - 前記プライミング部分は研削面を備えている、請求項4に記載のシステム。
- 前記プライミング部分は少なくとも1つの流体射出ポートを備えている、請求項4又は請求項5の何れか一項に記載のシステム。
- 前記空洞部の内部に配置されている複数の細胞を更に備えている、請求項1から請求項6の何れか一項に記載のシステム。
- 細胞送達システムであって、
直線状のシャフト部分を有する中心キャリア部分、前記シャフト部分の遠位端に配置されたプライミング部分を有する遠位部分、及び開口した遠位端と細胞を送達するための空洞部を画定する内周面とを有するシース部分を備えていて、前記シャフト部分が前記シース部分の前記空洞部内を延びており、前記遠位部分の組織穿通部分で終端している細長い本体、を備えており、
前記本体が、前記遠位部分が前記開口した遠位端を封止して前記遠位部分から前記シース部分の外面にかけて連続する滑らかな移行部を形成する第1形態にあるときに、前記組織穿通部分は組織の中へ押し進められることで組織を穿通するように配設されており、
前記プライミング部分は、前記組織穿通部分に隣接して配置されていて、当該プライミング部分が療法の所望される組織場所に隣接したときに当該プライミング部分の隣接の組織に治癒応答又は再生応答を生成するように配設されており、
前記本体が、前記シャフト部分が遠位方向に押されて前記遠位部分が前記シャフト部分の前記開口した遠位端から遠位方向に延在して前記開口した遠位端を開放する第2形態にあるときに、前記空洞部が、複数の細胞を前記本体に隣接する組織へ送達するように配設されている、システム。 - 前記空洞部の内部に配置されている複数の細胞を更に備えている請求項8に記載のシステム。
- 前記プライミング部分は研削面を備えている、請求項8又は請求項9に記載のシステム。
- 前記プライミング部分は少なくとも1つの流体射出ポートを備えている、請求項8から請求項10の何れか一項に記載のシステム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201361789518P | 2013-03-15 | 2013-03-15 | |
US61/789,518 | 2013-03-15 | ||
PCT/US2014/021699 WO2014149977A1 (en) | 2013-03-15 | 2014-03-07 | Cell injection needle |
Related Child Applications (1)
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JP2018220197A Division JP2019048157A (ja) | 2013-03-15 | 2018-11-26 | 細胞注入針 |
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JP2016515004A JP2016515004A (ja) | 2016-05-26 |
JP2016515004A5 JP2016515004A5 (ja) | 2017-02-09 |
JP6483655B2 true JP6483655B2 (ja) | 2019-03-13 |
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JP2016500811A Active JP6483655B2 (ja) | 2013-03-15 | 2014-03-07 | 細胞注入針 |
JP2018220197A Pending JP2019048157A (ja) | 2013-03-15 | 2018-11-26 | 細胞注入針 |
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US (1) | US10328213B2 (ja) |
EP (1) | EP2968752B1 (ja) |
JP (2) | JP6483655B2 (ja) |
WO (1) | WO2014149977A1 (ja) |
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CN110382020A (zh) * | 2016-12-28 | 2019-10-25 | 桑比欧公司 | 细胞递送系统及操作细胞递送系统的方法 |
JP2024040532A (ja) * | 2021-02-08 | 2024-03-26 | テルモ株式会社 | 医療器具 |
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- 2014-03-07 JP JP2016500811A patent/JP6483655B2/ja active Active
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EP2968752A1 (en) | 2016-01-20 |
JP2016515004A (ja) | 2016-05-26 |
JP2019048157A (ja) | 2019-03-28 |
US20140276368A1 (en) | 2014-09-18 |
EP2968752B1 (en) | 2023-09-06 |
EP2968752A4 (en) | 2017-03-22 |
WO2014149977A1 (en) | 2014-09-25 |
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