JP6480272B2 - Clean air device - Google Patents

Description

  The present invention is a sterilization gas that is harmful to the environment when released at a high concentration, used for sterilization of sterilization of safety cabinets, isolators, etc. used in research on pathogens, aseptic drugs, biological drugs, regenerative medicine, etc. The present invention relates to a device for disassembling a device and a method for using the device.

  For safety cabinets (class II cabinets for biohazard measures), isolators, etc. used in aseptic medicines, biological medicines, regenerative medicine, etc., if the material to be handled is changed, the previous experimental material will not be mixed with the next experimental material Thus, it is necessary to make the work space aseptic when switching work. In addition, when a device such as a safety cabinet used for research on pathogens is maintained, it is necessary to kill pathogens and the like inside the device. In order to kill pathogens and the like in these devices and make them sterile, after sealing the opening of the device, the device is filled with sterilization gas to make the device sterile. After the sterilization is completed, the sterilization gas filled in the apparatus is chemically neutralized, or the sterilization gas is decomposed through a decomposition catalyst such as activated carbon to obtain a concentration safe for the environment, and then the apparatus is opened.

  As background art of this technical field, there is JP-A-11-332550 (Patent Document 1). In this publication, a formaldehyde generator as a sterilization gas and a formaldehyde neutralizer are placed in the same space in a safety cabinet, and after the sterilization with formaldehyde is completed, the formaldehyde neutralizer is activated by heat. A method for degrading and neutralizing hydrides is described.

  Another background art in this technical field is JP-A-2014-159360 (Patent Document 2). In this publication, a chlorine dioxide gas generator and a chlorine dioxide gas decomposer are connected to a safety cabinet, and chlorine dioxide is fed from the chlorine dioxide gas generator into a sealed safety cabinet. Is incorporated into a chlorine dioxide gas decomposing apparatus, and a method for decomposing and neutralizing chlorine dioxide is described.

JP-A-11-332550 JP 2014-159360 A

  Although the sterilization by formaldehyde gas and the formaldehyde decomposition neutralization method of the above-mentioned prior art shown in Patent Document 1 are supposed to activate the neutralization device with heat at the time of sterilization gas decomposition, the neutralization device not activated with heat is In the same space as the formaldehyde generator. For this reason, some formaldehyde gas is decomposed and neutralized during sterilization with formaldehyde gas. In the method of Patent Document 1, it is necessary to generate formaldehyde gas in consideration of some decomposition during sterilization. The amount of formaldehyde gas generated can be adjusted by the amount of chemical used. In addition, the initial gas generation concentration at the time of formaldehyde gas sterilization is about 4000 to 5000 ppm, and the formaldehyde gas detector tubes that can measure up to 6400 ppm are commercially available. And sterilization time can be adjusted.

  The sterilization with chlorine dioxide gas and the chlorine dioxide gas decomposition neutralization method of the above-mentioned prior art shown in Patent Document 2 include a chlorine dioxide gas generator and a chlorine dioxide gas decomposition device in the same device, and a suction port and a blowout port. Is connected to the space to be sterilized, such as a safety cabinet or laboratory, and at the time of sterilization, chlorine dioxide gas, which is a sterilization gas, is introduced into the sterilization target from the blowout port, and the air to be sterilized is sucked from the suction port, Sterilization gas circulation. When decomposing and neutralizing chlorine dioxide, which is a sterilization gas, the sterilization gas sucked from the sterilization target is sent to the chlorine dioxide decomposition device side and returned to the sterilization target from the blowout port, thereby sterilizing the chlorine dioxide gas decomposition neutralization device. The air in the subject is circulated to perform neutralization. When the air is sent to the chlorine dioxide gas decomposition and neutralization device side, the chlorine dioxide gas concentration is measured by a commercially available chlorine dioxide concentration meter and the sterilization time is managed. Even in Patent Document 2, some air may leak to the chlorine dioxide gas decomposition and neutralization device side during sterilization, but it is possible to manage whether sterilization is effective by measuring the chlorine dioxide concentration. I can do it.

  In both Patent Document 1 and Patent Document 2, there is a possibility of sterilization gas decomposition by a sterilization gas decomposition neutralization apparatus during sterilization, but the effectiveness of sterilization is managed by measuring the sterilization gas concentration. A method for determining whether sterilization was effective is to place a biological indicator, which is a filter paper containing about 10 to the 6th power of bacteria serving as an indicator, in the sterilization target, cultivate the biological indicator after completion of the sterilization operation, It has been confirmed that there are no fungal colonies. However, since the culture takes about 7 days, the sterilization was effective when the concentration and time of the sterilization gas were controlled and the sterilization gas concentration was higher than the predetermined one when checking the safety cabinet. Then, the sterilization gas is decomposed to a safe concentration without waiting for 7 days of culture, and then the next operation is started.

  When using formaldehyde gas as sterilization gas, you can get a gas detector tube that can measure up to high sterilization effective concentration, but in the case of chlorine dioxide gas, hydrogen peroxide, etc., to measure the effective concentration for sterilization Instead of a gas detector tube, an expensive concentration meter is required. A gas detector tube with an appropriate measurement concentration is available to confirm whether the concentration has dropped to a safe concentration.

  An object of the present invention is to provide a sterilization technique in which a sterilization gas is not decomposed by a decomposition neutralization catalyst during sterilization, and the sterilization gas that is input can be used effectively for sterilization.

  In order to solve the above-described problems, the present invention employs the configurations described in the claims.

  An example of the sterilization gas decomposition apparatus of the present invention is a sterilization gas decomposition apparatus that can be attached to a clean air apparatus, wherein a flow path inlet and a flow path outlet are formed, and a flow path surrounded by a wall surface is provided. A blower disposed in the flow path, a closed cracking catalyst holding outer wall connected to a wall surface of the flow path, and a cracking catalyst disposed in a cracking catalyst holding space inside the cracking catalyst holding outer wall. In the sterilization, the flow path and the decomposition catalyst holding space are separated from each other by a partition part, and in the case of sterilization gas decomposition, the decomposition catalyst can be moved into the flow path.

  Moreover, if an example of the usage method of the sterilization gas decomposing apparatus of the present invention is given, a flow path in which a flow path inlet and a flow path outlet are formed and surrounded by a wall surface, and a blower disposed in the flow path And a cracking catalyst holding outer wall connected and sealed to the wall surface of the flow path, and a cracking catalyst disposed in a cracking catalyst holding space inside the cracking catalyst holding outer wall, Clean the sterilization gas with the step of attaching the sterilization gas decomposing device to the clean air device, the step of sealing and curing the opening of the clean air device, and the flow path and the decomposition catalyst holding space separated by a partition. A step of spreading the inside of the air device, a step of introducing the decomposition catalyst into the flow path to decompose the sterilization gas, and confirming that the sterilization gas has been reduced to a safe concentration; Remove from the clean air unit, those comprising a step of returning to the state available clean air device.

  Further, if an example of the clean air device of the present invention is given, clean air including a work space, a blower that sucks air from the work space and sends clean air to the work space through a filter, and a sterilization gas generator The apparatus is provided with the sterilization gas decomposition apparatus described above, provided with an opening on the outer wall that becomes negative pressure when the blower of the clean air apparatus is operated, and the flow path inlet and the flow path outlet of the sterilization gas decomposition apparatus are provided, It is connected to the opening.

  As another example of the clean air device of the present invention, a work space, a blower that sucks air from the work space and sends clean air to the work space through a filter, and a sterilization gas generator A clean air device comprising: an opening provided on a wall surface of the work space or a wall surface of a space that becomes negative pressure during operation; a closed decomposition catalyst holding outer wall connected to the opening and sealed; and the decomposition A decomposition catalyst disposed in the decomposition catalyst holding space inside the catalyst holding outer wall, and in the case of sterilization, the flow path and the decomposition catalyst holding space are separated by a partition part, and in the case of sterilization gas decomposition The decomposition catalyst is configured to be movable in the flow path.

  According to the present invention, the sterilization target can be filled with a sterilization gas, and the sterilization gas can be circulated from the blowing means to effectively perform sterilization, and the sterilization gas is not decomposed by the sterilization gas decomposition catalyst during sterilization. Technology can be provided.

  Further, according to the present invention, the effectiveness of sterilization can be confirmed by managing the amount of chemicals injected into the sterilization target for sterilization without measuring the sterilization gas generation concentration during sterilization.

It is an example of the side cross-section figure of the sterilization gas decomposition | disassembly apparatus which shows the time of sterilization of Example 1 of this invention. It is an example of the cross-section figure of the sterilization gas decomposition | disassembly apparatus which shows the time of sterilization of Example 1 of this invention. It is an example of the side sectional structure figure of the sterilization gas decomposition | disassembly apparatus which shows the time of sterilization gas decomposition | disassembly of Example 1 of this invention. It is an example of the cross-section figure of the sterilization gas decomposition | disassembly apparatus which shows the time of sterilization gas decomposition | disassembly of Example 1 of this invention. It is an example of the cross-section figure of the safety cabinet which shows the time of sterilization of Example 1 of this invention. It is an example of the front view of the safety cabinet which shows the time of sterilization of Example 1 of this invention. It is an example of AA sectional view of Drawing 3B. It is an example of the sectional side view figure of the safety cabinet which shows the time of sterilization gas decomposition | disassembly of Example 1 of this invention. It is an example of the cross-section figure of the safety cabinet which shows the time of sterilization gas decomposition | disassembly of Example 1 of this invention. It is an example of AA sectional view of Drawing 4B. It is an example of the side cross-section figure of the safety cabinet which shows the time of sterilization of Example 2 of this invention. It is an example of the front view of the safety cabinet which shows the time of sterilization of Example 2 of this invention. It is an example of AA sectional view of Drawing 5B. It is an example of the side cross-section figure of the safety cabinet which shows the time of sterilization gas decomposition | disassembly of Example 2 of this invention. It is an example of the cross-section figure of the safety cabinet which shows the time of sterilization gas decomposition | disassembly of Example 2 of this invention. It is an example of AA sectional view of Drawing 6B. It is an example of the side cross-section figure of the safety cabinet which shows the time of sterilization of Example 3 of this invention. It is an example of the cross-section figure of the safety cabinet which shows the time of sterilization of Example 3 of this invention. It is an example of the cross-section figure of the safety cabinet which shows the time of sterilization gas decomposition | disassembly of Example 3 of this invention. It is an example of the cross-section figure of the safety cabinet which shows after completion | finish of sterilization of Example 3 of this invention. It is an example of the cross-section figure of the safety cabinet which shows the time of sterilization of Example 4 of this invention. It is an example of the cross-section figure of the safety cabinet which shows the time of sterilization gas decomposition | disassembly of Example 4 of this invention. It is an example of the side cross-section figure of the safety cabinet which shows the time of sterilization of Example 5 of this invention. It is a flowchart of the sterilization of the Example of this invention, and a sterilization gas decomposition | disassembly operation | work.

  Examples of the present invention will be described below with reference to FIGS. 1A to 13. In each drawing for explaining the embodiment, elements having the same function are given the same name and reference numeral, and repeated explanation thereof is omitted.

  1A is an example of a side cross-sectional structure diagram of a sterilization gas decomposing apparatus showing a sterilization process or a state at the time of sterilization in Example 1. FIG. FIG. 1B is an example of a cross-sectional structure diagram of the sterilization gas decomposition apparatus showing the sterilization time of the first embodiment. Although it is described as sterilization or sterilization gas decomposition, it does not indicate the exact moment, but indicates the concept of sterilization process or sterilization or sterilization gas decomposition process or sterilization gas decomposition process.

  A channel inlet 105 (also referred to as a first opening) and a channel outlet 106 (also referred to as a second opening) are formed on a part of the wall surface of the channel 103 surrounded by a wall surface. .

  The flow path inlet 105 and the flow path outlet 106 may be different places or the same place, but different places are more efficient as a flow of airflow. By disposing the cracking catalyst blower 101 in the flow path 103 and operating the cracking catalyst blower 101, air is sucked from the flow path inlet 105 and blown out from the flow path outlet 106.

  The channel inlet 105 that is the first opening is connected to the channel outlet 106 that is the second opening via the channel 103.

  A cracking catalyst holding outer wall 107 is connected to a wall surface (also referred to as a side surface portion) constituting the flow path 103. The cracking catalyst holding outer wall 107 is formed of a stretchable or deformable material such as a bellows, a rubber plate, vinyl, etc., or a cylindrical space is doubled, a gasket is sandwiched between gaps between the cylinders, and is stretchable. And it is the structure which maintained airtightness. In the cracking catalyst holding space 104 inside the cracking catalyst holding outer wall 107, a cracking catalyst 102 (also referred to as gas cracking means) is disposed. A partition 108 is formed in a part of the cracking catalyst 102, and the partition 108 is in contact with the outer wall of the flow path 103. The flow path 103 and the decomposition catalyst holding space 104 are separated by a partition 108. As the isolation method, a gasket may be formed on the partition 108 or may be attached with an adhesive tape.

  At the time of sterilization, by operating the blower 101 for the decomposition apparatus, sterilization gas enters from the flow path inlet 105, passes through the flow path 103, and is discharged from the flow path outlet 106. At this time, since the sterilization gas does not enter the sterilization catalyst holding space 104 by the partition portion 108, the sterilization gas is prevented from being decomposed by the decomposition catalyst 102.

A certain amount of time is maintained for sterilization. Sterilization time varies depending on the type and concentration of the sterilization gas used, and in the US safety cabinet standard, NSF / ANSI49, 11 g of formaldehyde gas is used for 1 m ³ of volume in the safety cabinet, and it is at least 6 hours. evening (12 hours) retention, was charged with 1 m ³ per 4.7g in chlorine dioxide gas, it is introduced with a minimum of 85 minute hold.

  The sterilization gas decomposing apparatus 100 of the present invention has been described with respect to an example in which the sterilizing gas decomposing apparatus 100 is mounted on or configured as a part of the safety cabinet 109. These safety cabinets, isolators, and cleaning work tables are collectively referred to as a clean air device.

  Here, the clean air device is a clean work table and safety cabinet that is a class II cabinet for biohazard countermeasures, another class of biohazard countermeasure cabinets, and cleans the inside of the experimental table to prevent the invasion of germs outside the device. This is a concept including a clean room in which clean work air flows into a region surrounded by a work table, an isolator, and a work table to be protected and from a part of the work table.

  Each embodiment of the present invention can be appropriately employed in these devices. In the present invention, a safety cabinet will be described as a representative of a clean air device.

  FIG. 2A is an example of a side cross-sectional structure diagram of the sterilization gas decomposition apparatus showing the sterilization gas decomposition according to the first embodiment. FIG. 2B is an example of a cross-sectional structure diagram of the sterilization gas decomposition apparatus showing the sterilization gas decomposition according to the first embodiment.

  At the time of sterilization gas decomposition, the decomposition catalyst 102 is introduced into the flow path 103 by pushing the decomposition catalyst holding outer wall 107. At this time, the partition part 108 is peeled off from the outer wall of the flow path 103, but the method of sealing the partition part 108 with the outer wall of the flow path 103 allows easy movement of the cracking catalyst 102 because a gasket or adhesive tape is attached. It becomes. After introducing the cracking catalyst 102 into the flow path 103, the flow path 103 and the cracking catalyst holding space 104 are connected, and sterilization gas may enter the cracking catalyst holding space 104, but the cracking catalyst holding outer wall 107 has a sealing property. Since it has, sterilization gas does not leak outside. By introducing the cracking catalyst 102 into the flow path 103 and operating the cracking catalyst blower 101, the air that has entered from the flow path inlet 105 passes through the cracking catalyst 102 and is discharged from the flow path outlet 106.

  FIG. 3A is an example of a sectional structural view of the safety cabinet showing the sterilization of the first embodiment. FIG. 3B is an example of a front view of the safety cabinet illustrating the sterilization of the first embodiment. 3C is an example of the AA cross-sectional view of FIG. 3B of the safety cabinet showing the sterilization of the first embodiment.

  A work space 114 is provided in the safety cabinet 109, and a front shutter 112 is formed on one surface of the work space 114, and a front opening 111 is formed below the front shutter 112. An operator inserts an arm from the front opening 111 and performs an experiment work such as a pathogen. The safety cabinet may be expressed as a biohazard countermeasure cabinet. The safety cabinet 109 has a safety cabinet blower 115, and a pressure chamber 116 is connected to the safety cabinet blower 115. An exhaust HEPA filter 110 a and a blowout HEPA filter 110 b are connected to the pressure chamber 116. HEPA filter is an abbreviation for High Efficiency Particulate Air Filter. A working space 114 is formed on the surface opposite to the pressure chamber 116 of the blowout HEPA filter 110b, and an exhaust port 119 is formed on the surface opposite to the pressure chamber 116 of the exhaust HEPA filter 110a. When the safety cabinet 109 is used, by operating the safety cabinet blower 115, the pressure chamber 116 is pressurized, and dust that may contain a pathogen is filtered by the blowout HEPA filter 110b to obtain clean air. Clean air is blown into the work space 114. A lower surface of the working space 114 forms a work table 118, and a suction grill 113 is formed on the front opening 111 side of the work table 118. The air sucked from the suction grill 113 passes through the rear flow path 117 and is sucked into the safety cabinet blower 115. The air on the exhaust HEPA filter 110a side connected to the pressure chamber 116 filters out dust including a pathogen by the exhaust HEPA filter 110a, and is blown out from the exhaust port 119 as clean air.

  When maintaining the HEPA filter and the blower inside the safety cabinet 109 or when changing the experimental material handled in the work space 114, it is necessary to kill pathogens and the like existing in the safety cabinet 109. This operation is called sterilization or decontamination, and the level at which pathogens and the like are killed is a level at which 10 6 pathogens and the like become zero.

  At the time of sterilization, the sterilization gas decomposition apparatus 100 is attached to the safety cabinet 109. The mounting is performed by using the opening of the front opening 111 of the safety cabinet 109 so that the front opening 111 and the flow path inlet 105 and the flow path outlet 106 of the sterilization gas decomposing apparatus 109 face each other. The sterilization gas decomposition apparatus 100 is sealed with a sealing sheet 121 such as an adhesive tape. When the front opening 111 is not used, an opening such as the exhaust port 119 may be used. Since it is necessary to seal the safety cabinet 109 during sterilization, when the sterilization gas decomposition apparatus 100 is attached to the front opening 111, the exhaust port 119 is sealed with the exhaust port sealing sheet 120. Depending on the structure of the safety cabinet 109, it may be insufficient to seal the exhaust port 119 and the front opening 111, and the other openings are similarly sealed with the sealing sheet 121.

  When the sterilization target is an isolator instead of the safety cabinet 109 having an opening, an opening that can be opened and closed is provided in the isolator, and a sterilization gas decomposing apparatus may be attached to the opening. When the opening size of the front opening 111 and the size of the sterilization gas decomposition apparatus 100 do not match, the opening is sealed by the opening sealing member 124. For sterilization, the inside of the safety cabinet 109 needs to be filled with the sterilization gas 122. When the sterilization gas generator 123 is disposed on the work table 118 and the safety cabinet 109 is sealed, the sterilization gas 122 may be generated remotely by a timer or the like. The safety cabinet 109 may be finally sealed by the opening sealing member 124 at the initial stage of generation of the sterilization gas 122 after the drug is put into the chemical solution of the sterilization gas generator 123. Since the chemical reaction does not take a long time, the start of the chemical injection may be set as the sterilization start time.

  After the sterilization gas 122 is generated, the sterilization gas 122 is circulated in the safety cabinet by operating the safety cabinet blower 115, and the sterilization gas 122 is distributed in the safety cabinet 109. When the blower 101 for the decomposition apparatus in the sterilization gas decomposition apparatus 100 is operated, the sterilization gas 122 in the safety cabinet 109 enters the sterilization gas decomposition apparatus 100 from the flow path inlet 105 and enters the safety cabinet 109 from the flow path outlet 106. . At this time, since the decomposition catalyst 102 is in a space different from the flow path 103 of the sterilization gas decomposition apparatus 100, the sterilization gas 122 does not touch the decomposition catalyst 102. During sterilization, the sterilization gas 122 is decomposed by the decomposition catalyst 102. It is never done. Since the sterilization gas 122 is circulated in the safety cabinet 109 by the safety cabinet blower 115, it is not an essential item to operate the disassembly device blower 101 during sterilization. Even if the cracking catalyst blower 101 is not operated, the sterilization gas 122 may enter the flow path 103. However, since the decomposition catalyst 102 does not exist in the flow path 103, the sterilization gas 122 is not decomposed. It is not decomposed by 102.

  Sterilization means that when the sterilizing gas 122 reacts and decomposes with a pathogen or the like, the pathogenic agent or the like is also decomposed to make it sterile.

  FIG. 4A is an example of a side cross-sectional structure diagram of the safety cabinet showing the sterilization gas decomposition of the first embodiment. FIG. 4B is an example of a cross-sectional structure diagram of the safety cabinet showing the sterilization gas decomposition according to the first embodiment. FIG. 4C is an example of the AA cross-sectional view of FIG. 4B of the safety cabinet showing the sterilization gas decomposition of the first embodiment.

  After the sterilization in the safety cabinet 109 is completed, the remaining sterilized gas 122 is decomposed. The determination of the completion of sterilization can be performed by calculating the concentration of the sterilization gas 122 generated inside from the volume in the safety cabinet 109 and the input amount of the sterilization gas 122. In the present invention, since the sterilization gas is not decomposed by the decomposition catalyst during sterilization, all of the input amount is used for sterilization. Therefore, it is possible to determine the end of sterilization based on the chemical amount for generating sterilization gas and the sterilization time.

  In order to decompose the sterilization gas, the decomposition catalyst 102 is introduced into the flow path 103 during the operation of the decomposition catalyst fan 101. Since the cracking catalyst blower 101 is in operation, at the time of sterilization gas decomposition, the sterilization gas 122 in the safety cabinet 109 is sucked from the flow path inlet 105, passes through the decomposition catalyst 102, and flows from the flow path outlet 106 into the safety cabinet 109. The sterilization gas 122 circulates in the safety cabinet 109 by blowing out. As the sterilization gas 122 passes through the decomposition catalyst 102 many times, the sterilization gas 122 is decomposed.

  According to the present embodiment, at the time of sterilization, since the flow path of the sterilization gas decomposition apparatus and the decomposition catalyst holding space are separated by the partition portion, the sterilization target is filled with the sterilization gas, and the sterilization gas is supplied from the blowing means. The sterilization can be effectively performed by circulation, and the sterilization gas is not decomposed by the sterilization gas decomposition catalyst during the sterilization. And at the time of sterilization gas decomposition | disassembly, a decomposition | disassembly catalyst can be moved in a flow path, and sterilization gas can be decompose | disassembled reliably.

  In addition, according to the present embodiment, since the sterilization gas is not decomposed by the sterilization gas decomposition catalyst during sterilization, the amount of chemicals put into the sterilization target for sterilization without measuring the sterilization gas generation concentration The effectiveness of sterilization can be confirmed by managing the above.

  FIG. 5A is an example of a side sectional view of the safety cabinet showing the sterilization of the second embodiment. FIG. 5B is an example of a front view of the safety cabinet illustrating the sterilization of the second embodiment. FIG. 5C is an example of the AA cross-sectional view of FIG. 5B of the safety cabinet illustrating the sterilization of the second embodiment.

The sealing and curing method for the safety cabinet 109 is the same as that in the first embodiment.
A gas input port 125 is provided on the outer wall of the flow path 103 of the sterilization gas decomposing apparatus 100, and the sterilization gas 122 is input from the sterilization gas generator 123 into the flow path 103. When the sterilizing gas is supplied, the disinfector blower 101 is operated, so that the sterilizing gas 122 enters the safety cabinet 109 from the flow path outlet 106, and the air in the safety cabinet 109 is taken in from the flow path inlet 105. The air can be circulated while introducing the sterilizing gas 122.

  FIG. 6A is an example of a side cross-sectional structure diagram of the safety cabinet showing the sterilization gas decomposition of the second embodiment. FIG. 6B is an example of a cross-sectional structure diagram of the safety cabinet showing the sterilization gas decomposition of the second embodiment. 6C is an example of the AA cross-sectional view of FIG. 6B of the safety cabinet showing the sterilizing gas decomposition time according to the second embodiment of the present invention.

  At the time of sterilization gas decomposition, the sterilization gas generator 123 is stopped and the decomposition catalyst 102 is put into the flow path 103. By operating the blower 101 for the decomposition catalyst even after the decomposition catalyst 102 is charged, the sterilization gas 122 in the safety cabinet 109 passes through the decomposition catalyst 102 many times, so that the sterilization gas 122 can be decomposed and neutralized. .

  According to the present embodiment, in addition to the effects of the first embodiment, a gas input port is provided on the outer wall of the flow path of the sterilization gas decomposing apparatus so that sterilization gas from the sterilization gas generator can be input. There is no need to provide a sterilization gas generator. In addition, the mounting structure of the sterilization gas generator can be simplified.

  FIG. 7A is an example of a side cross-sectional structure diagram of the safety cabinet showing the sterilization of the third embodiment. FIG. 7B is an example of a cross-sectional structure diagram of the safety cabinet illustrating the sterilization of the third embodiment.

  A decomposition catalyst charging port 126 is provided on a part of the outer wall that becomes negative pressure when the safety cabinet 109 is operated. A cracking catalyst holding outer wall 107 having a cracking catalyst 102 inside is connected to the cracking catalyst inlet 126 by a cracking catalyst case connecting portion 127. With this connection, the hermeticity inside the safety cabinet 109 is maintained. During sterilization in the safety cabinet 109, the exhaust port 119 is sealed with the exhaust port sealing sheet 120, the opening under the front shutter 112 is cured with the sealing sheet 121, and the remaining opening is also sealed with the sealing sheet 121. This completes the sealing for sterilization.

  In order to generate the sterilization gas 122 in the safety cabinet 109, a part of the sealing sheet 121 is opened, the sterilization gas generator 123 is started from the open part, or the chemical is reacted, and the sterilization gas generation initial stage The safety cabinet 109 is sealed with the sealing sheet 121 during the stage.

  After the sterilization gas 122 is generated, the sterilization gas 122 circulates inside the safety cabinet 109 by operating the safety cabinet blower 115, and the sterilization gas 122 reaches the inside. During sterilization, since the decomposition catalyst 102 is located in the decomposition catalyst holding outer wall 107 that is separated from the inside of the safety cabinet 109 by the partition 108, all of the sterilization gas 122 is used for sterilization of pathogens and decomposed by the decomposition catalyst 102. Is prevented.

  FIG. 8 is an example of a cross-sectional structure diagram of the safety cabinet showing the sterilization gas decomposition of the third embodiment. After holding the sterilization time, the decomposition catalyst holding outer wall 107 is operated from the outside, and the decomposition catalyst 102 is put into the safety cabinet 109. The cracking catalyst 102 may be hooked so that the cracking catalyst 102 is not released into the safety cabinet 109. By operating the safety cabinet blower 115, the sterilization gas 122 inside the safety cabinet 109 passes through the decomposition catalyst 102, and the sterilization gas 122 is gradually decomposed.

  FIG. 9 is an example of a cross-sectional structure diagram of the safety cabinet after the completion of sterilization in the third embodiment. After completion of sterilization, the decomposition catalyst holding outer wall 107 is removed together with the decomposition catalyst 102 from the safety cabinet 109, and a decomposition catalyst charging port sealing cover 128 is attached to the decomposition catalyst charging port 126 to seal the opening. Since the cracking catalyst input port 126 is provided on the outer wall that becomes a negative pressure during operation of the safety cabinet 106, even if the sealing cabinet is inadequate, pathogens etc. inside the safety cabinet 109 may be exposed to the outside of the safety cabinet 109. There is no leakage.

  According to this embodiment, the cracking catalyst charging port is provided in a part of the outer wall that becomes negative pressure during the operation of the safety cabinet, the cracking catalyst holding outer wall having the cracking catalyst is connected inside, and at the time of sterilization, the cracking catalyst holding space and Since the decomposition catalyst can be moved into the safety cabinet during sterilization gas decomposition, the sterilization target is filled with the sterilization gas and sterilized by circulating the sterilization gas from the blower. It can be done effectively. Further, during sterilization, the sterilization gas is not decomposed by the sterilization gas decomposition catalyst. And at the time of sterilization gas decomposition | disassembly, a decomposition | disassembly catalyst can be moved in a flow path, and sterilization gas can be decompose | disassembled reliably.

  FIG. 10 is an example of a cross-sectional structure diagram of the safety cabinet illustrating the sterilization of the fourth embodiment. A decomposition catalyst moving device 129 is provided on the side of the decomposition catalyst holding outer wall 107 of the sterilization gas decomposition device 100. The cracking catalyst moving device 129 may be one that pushes the cracking catalyst 102 toward the flow path 103 by electrically starting a motor, or one that pushes the cracking catalyst 102 toward the flow path 103 using air pressure.

  At the time of sterilization, the sterilization gas decomposing apparatus 100 is placed in the safety cabinet 109, and the opening is hermetically cured as in the other embodiments. At this time, the electric wiring, the air tube, and the like for remotely operating the cracking catalyst moving device 129 are formed so as to penetrate the sealed curing unit.

  At the time of sterilization, the sterilization gas 122 is filled by a method of introducing the sterilization gas 122 into the safety cabinet 109 or a method of generating a sterilization gas 122 by reacting a chemical inside. The cracking catalyst 102 is disposed in the safety cabinet 109 together with the sterilization gas decomposing apparatus 100. However, the cracking catalyst holding space 104 is isolated from the flow path 103 of the sterilizing gas decomposing apparatus 100 by the cracking catalyst holding outer wall 107 and the partition 108. Therefore, the sterilization gas 122 does not touch the decomposition catalyst 102 during sterilization.

  During the sterilization, by operating the decomposition catalyst blower 101 and the safety cabinet blower 115, the sterilization gas 122 is diffused into the safety cabinet 109 and can be sterilized to every corner.

  FIG. 11 is an example of a cross-sectional structure diagram of the safety cabinet showing the sterilization gas decomposition of the fourth embodiment. When the sterilization gas is decomposed after holding the sterilization time, the decomposition catalyst moving device 129 is moved, and the decomposition catalyst 102 is put into the flow path 103 of the sterilization gas decomposition device 100. The sterilization gas 122 of the safety cabinet 109 enters the sterilization gas decomposition apparatus 100 from the flow path inlet 105, passes through the decomposition catalyst 102, and is discharged from the flow path outlet 106 by operating the cracking catalyst blower 101 even after the charging. . By repeating this flow, the sterilization gas in the safety cabinet 109 is decomposed by the decomposition catalyst 102.

  According to the present embodiment, in addition to the effect of the first embodiment, the disassembly catalyst moving device is provided on the disassembly catalyst holding outer wall side of the sterilization gas decomposition device so that it can be remotely operated. It can be attached at any position. In addition, workability related to sterilization can be improved.

  FIG. 12 is an example of a side sectional view of the safety cabinet showing the sterilization of the fifth embodiment. An opening is provided in the outer wall that becomes negative pressure when the safety cabinet blower 115 of the safety cabinet 109 is operated, and the flow path inlet 105 and the flow path outlet 106 of the sterilization gas decomposition apparatus 100 are connected to the opening. A gas input port 125 is provided on the outer wall of the flow path 103 of the sterilization gas decomposing apparatus 100 and a sterilization gas generator 123 is connected.

  Since the safety cabinet 109 and the sterilization gas decomposing apparatus 100 are hermetically connected, the sealing operation is completed by sealing the opening 119 of the safety cabinet 109 and the opening of the front shutter 112 during sterilization.

  At the time of sterilization, the sterilization gas 122 is introduced from the sterilization gas generator 123 into the flow path 103 in a state where the decomposition catalyst 102 has not moved to the flow path 103, and the sterilization gas is put into the safety cabinet 109 by the blower 101 for decomposition apparatus. 122 can be input. At this time, by operating the safety cabinet blower 115, the sterilization gas 122 is distributed in the safety cabinet 109.

  At the time of sterilization gas decomposition, by introducing the decomposition catalyst 102 into the flow path 103 and operating the decomposition catalyst blower 101, the sterilization gas 122 circulates through the decomposition catalyst 102 many times, and the decomposition of the sterilization gas proceeds.

  After the sterilization is finished, the safety cabinet 109 is sealed and removed, and the safety cabinet 109 is returned to a usable state.

FIG. 13 is a flowchart of the sterilization and sterilization gas decomposition operation of the above embodiment.
In the state of FIG. 1 where the decomposition catalyst 102 in the sterilization gas decomposition apparatus 100 is outside the flow path 103, the sterilization gas decomposition apparatus 100 is attached to the safety cabinet 109 using an opening such as the front opening 111 of the safety cabinet 109. Attach (S1301).
Next, the remaining opening of the safety cabinet 109 is hermetically sealed (S1302). At this time, part of the safety cabinet 109 may be opened for the reaction of chemicals, and the whole may be sealed after the chemical reaction starts.
A sterilization gas per unit volume to be sterilized, which is effective for sterilization described in the US safety cabinet standard NSF / ANSI 49 or the like, is generated or introduced into the safety cabinet 109 (S1303).
By operating the safety cabinet blower 115 or the cracking catalyst blower 101, the inside of the safety cabinet 109 is agitated and the sterilization gas is spread to every corner (S1304).
The sterilization time that is effective for each sterilization gas is held (S1305).
After the sterilization time elapses, the decomposition catalyst 102 is introduced into the flow path 103 of the sterilization gas decomposition apparatus 100, and the decomposition apparatus blower 101 is operated, so that the decomposition catalyst 102 in the flow path 103 is sterilized gas many times. 122 is induced | guided | derived and a sterilization gas is decomposed | disassembled (S1306).
Whether or not the sterilizing gas 122 is released into the general air has been reduced to a safe concentration is determined by confirming the air in the safety cabinet 109 by sucking and measuring because the gas detector tube for low concentration is commercially available. (S1307).
After confirming that the concentration has decreased to a safe concentration, the sterilization gas decomposition apparatus 100 and the sealed curing are removed from the safety cabinet 109, and the safety cabinet 109 is returned to a usable state (S1308).

  The cracking catalyst 102 that has moved to the state of FIG. 2 is pushed out from the flow path 103 side to the cracking catalyst holding space 104 side, and is used again after being attached to the safety cabinet 109 before sterilization at the START point in the flowchart of FIG. I can do it.

  In the embodiment, an example of a safety cabinet is shown, but an isolator that maintains the sterility of the inside may be used. In the case of an isolator, since there is no front opening 111 like a safety cabinet, a dedicated opening for opening and closing the sterilization gas decomposing apparatus is provided, or a state where it is incorporated in the apparatus as shown in FIG. But it ’s okay. In the case of an isolator, a clean space may be maintained with a positive pressure inside. In that case, the connection part with the sterilization gas decomposing apparatus may not be limited to the negative pressure wall surface.

  When incorporated in an isolator, the sterilization gas generation (introduction) step in the flowchart of FIG. 13 is started, the sterilization effective time elapse determination, and the operation of charging the decomposition catalyst shown in Example 4 from the outside are performed by a timer or the like. May be automated.

DESCRIPTION OF SYMBOLS 100 Sterilization gas decomposition apparatus 101 Fan for decomposition apparatus 102 Decomposition catalyst 103 Channel 104 Decomposition catalyst holding space 105 Channel inlet 106 Channel outlet 107 Decomposition catalyst holding outer wall 108 Partition 109 Safety cabinet 110a Exhaust HEPA filter 110b Outlet HEPA filter 111 Front opening 112 Front shutter 113 Suction grill 114 Work space 115 Safety cabinet blower 116 Pressure chamber 117 Rear flow path 118 Worktable 119 Exhaust opening 120 Exhaust opening sealing sheet 121 Sealing sheet 122 Sterilization gas 123 Sterilization gas generator 124 Opening sealing Member 125 gas inlet 126 cracking catalyst inlet 127 cracking catalyst case connecting portion 128 cracking catalyst inlet sealing cover 129 cracking catalyst moving device

Claims (6)

A clean air device including a work space, a blower that sucks air from the work space and sends clean air to the work space through a filter, and a sterilization gas generator,
Equipped with a sterilization gas decomposition device,
The sterilization gas decomposition apparatus comprises:
A flow path inlet and a flow path outlet are formed, and the flow path is surrounded by a wall surface.
A blower disposed in the flow path;
A cracked catalyst holding outer wall that is connected to and sealed with the wall surface of the flow path;
A cracking catalyst disposed in a cracking catalyst holding space inside the cracking catalyst holding outer wall,
The cracking catalyst holding outer wall is formed so as to be stretchable or deformable, and is configured so that the cracking catalyst can be put into the flow path by pushing the cracking catalyst holding outer wall,
In the sterilization step, the flow path and the decomposition catalyst holding space are separated by a partition part, and in the sterilization gas decomposition step, the decomposition catalyst can be moved into the flow path,
When opening the blower of the clean air device, provide an opening on the outer wall that becomes negative pressure,
A clean air device in which the flow path inlet and the flow path outlet of the sterilization gas decomposition apparatus are connected to the opening. In the clean air apparatus according to claim 1,
A clean air device having a gas inlet on a wall surface of a flow path of the sterilizing gas decomposing apparatus and capable of supplying a sterilizing gas from the sterilizing gas generator. In the clean air apparatus according to claim 1,
A clean air device in which a disassembly catalyst moving device is provided in the sterilization gas decomposition device, and the disassembly catalyst can be introduced into the flow path by remote operation from the outside. A clean air device including a work space, a blower that sucks air from the work space and sends clean air to the work space through a filter, and a sterilization gas generator,
Provide a sterilization gas decomposition apparatus in the work space,
The sterilization gas decomposition apparatus comprises:
A flow path inlet and a flow path outlet are formed, and the flow path is surrounded by a wall surface.
A blower disposed in the flow path;
A cracked catalyst holding outer wall that is connected to and sealed with the wall surface of the flow path;
A cracking catalyst disposed in a cracking catalyst holding space inside the cracking catalyst holding outer wall,
A clean air device in which the flow path and the decomposition catalyst holding space are separated by a partition during the sterilization process, and the decomposition catalyst can be moved into the flow path during the sterilization gas decomposition process. In the clean air apparatus according to claim 4,
A clean air device in which a disassembly catalyst moving device is provided in the sterilization gas decomposition device, and the decomposition catalyst can be introduced into the flow path by remote operation from outside. A clean air device having a work space, a blower that sucks air from the work space and sends clean air to the work space through a filter, and a gas decomposition device,
The gas decomposition apparatus comprises:
A gas decomposition means, a first opening, and a second opening connected via a flow path connected to the first opening;
A gas decomposition means storage unit is configured on the side surface of the flow path,
Having gas decomposition means stored in the gas decomposition means storage or disposed in the flow path;
In the case where the gas decomposition means is stored in the gas decomposition means storage section, the air taken in from the first opening is discharged from the second opening without passing through the gas decomposition means. And when the gas decomposing means is disposed in the flow path, the air taken in from the first opening passes through the gas decomposing means to the second opening. A second state discharged from the
The side surface portion of the flow path is extendable or deformable, and the gas decomposition means is disposed in the flow path by expanding or contracting or deforming the side surface portion.
When the blower of the clean air device is operated, an opening is provided on the outer wall that becomes negative pressure,
The clean air apparatus which connected the said 1st opening part and said 2nd opening part of the said gas decomposition apparatus to the said opening part provided in the said outer wall.

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