JP6426283B2 - Sterilizer using hydrogen peroxide and ozone vaporized and formulated through multicapillary tubes - Google Patents

Description

  The present invention relates to a method and apparatus for sterilization / disinfection using ozone, comprising humidifying the charge in the sterilization / disinfection chamber and transporting the ozone through the multicapillary to the vaporizer / mixer chamber Based on steam injection of hydrogen or other chemicals. Humidification and mixing accuracy control the introduction of liquid in multi-capillary in vaporizer / mixer by dropping control, temperature of 20 ° C to 130 ° C in a strong sterilization / disinfectant heated sterilization / disinfection chamber It is secured by generating at The method is carried out in a chamber equipped with one or two doors (with or without a sanitary barrier) warmed at a temperature of 20 <0> C to 130 <0> C. Disinfectant / disinfectant decomposition can be a high voltage plasma generator, or any other similar method that converts the sterilizing / disinfecting gas into water, oxygen, and free radicals when the sterilizing / disinfecting gas is pumped out of the chamber Is secured by

Prior inventions The document WO 030 72 150 discloses a steam generating unit which accepts an aqueous hydrogen peroxide solution and which contains a desiccant cartridge product.

  The document EP 1 764 115 describes a sterilization system comprising a hydrogen peroxide generator. The system has space for the introduction of hydrogen peroxide in the treatment space and in the dehumidifier. It is important to mention that there is a path of dehumidified air between the dehumidifier and the treatment space.

  The document CA 2519664 describes a sterilization method in which the hydrogen peroxide solution is dropped from the injector to the evaporator at a flow of 5 g / min for 3 minutes. The working chamber is filled with hydrogen peroxide after the relative humidity inside it has decreased to 1 to 10%. Sterilization occurs by saturation of hydrogen peroxide in the working chamber.

  It is necessary to mention the technical documents in the application of the applicant EP 0 639 980 11 relating to hydrogen peroxide sterilization methods and devices. According to the patent application, the high pressure inside the plasma generator, which may be part of the chamber, causes the hydrogen peroxide discharged from the chamber to be burned.

  The new patent application presented here is the result of the development and improvement of the invention described in patent application EP 0 639 980 11.

  We also mention that the method presented in the present application is different from that of the patent PCT / PT2007 / 000029 to which the applicant owns the rights. According to the state of the art and research made based on the above patents, various capillaries are used to introduce hydrogen peroxide or other chemicals according to the characteristics of the cycle, humidify the charge in the chamber, external A multicapillary vaporizer has been provided which transports the generator generated ozone to the chamber and transports it to the material to be disinfected or disinfected.

  Depending on the material to be disinfected or disinfected, this modification allows for the use of different concentrations of hydrogen peroxide or other chemicals, and different humidification amounts, for each type of cycle. Capillary tubes are introduced to provide high accuracy drop dosing in the vaporizer / mixer. Humidification is the transport of ozone to the material to be disinfected or disinfected.

  This new method has the ability to obtain the same sterilization / disinfection results as the previous patent PCT / PT2007 / 000029, but only one capillary is used in the previous system, whereas this new system is multi-capillary Because it is used, it has higher accuracy in instillation administration systems. In the previous patent, sterilization is achieved with hydrogen peroxide. In this new method, the multicapillaries allow lower concentrations of hydrogen peroxide or other chemicals to be reblended in the vaporizer / mixer and to be a disinfectant / disinfectant in this new device. Get the same result as the patented device. This method makes it possible to formulate various chemical products to obtain a disinfectant / disinfectant.

  The method presented also comprises a system of adjustable fixed dose in which air is removed prior to the onset of vaporization. Said adjustable dose may be pre-adjusted.

  The sterilization or disinfection method using the new device is less corrosive when it comes in contact with the material, especially the flexible endoscope, as the lower concentration and lower amount of hydrogen peroxide will come into contact with the material.

Advantages of the Device of the Present Invention-The drop evaporation device provides accuracy via computer control system, the accuracy obtained by using chemical products, dropping and capillary tubes in the vaporizer to mix and control fluctuating doses. Because it has an advantage over existing devices. The computer continuously monitors and controls the humidification performed with the chemical and the operation of the device via various pressure and / or temperature and / or humidity and / or concentration sensors.

Vaporizer / mixer (4G) vaporizes 0.01 ml to 1000 ml of liquid chemical through capillary tube (4D). During this phase, hydrogen peroxide, acetic acid, peracetic acid, water, formaldehyde or other chemical products such as formaldehyde with water, or DNA or RNA levels in a vaporizer / mixer to create a moist environment To control the introduction of ozone mixed with other chemicals that work with it, products themselves or products that combine them, or chemicals such as hydrogen peroxide, acetic acid, peracetic acid, water, formaldehyde or formaldehyde containing water or DNA or other chemical products which act at the RNA level, for controlling the introduction of no ozone product, which combines the product itself or these, or introduction of ethylene oxide that is blended with propylene oxide or water that has been formulated with water Several electric valves (4E to control the 4H, 13A, and 13E) is open, is then sucked vaporizer / mixer from (4G) the sterilization chamber (1). It will be understood that the above chemical products are commercially available and will be used in the form of a formulation.

  -For injection, the injection device does not have a syringe-injector but has a set of capillary tubes inside the vaporizer to convert the liquid into a moist spray gas, which is mixed with ozone or other chemicals, Make a disinfectant / disinfectant. The heat generated by the heating element or microwave system may be used as a heat source for the vaporization. The vaporization may be improved by an ultrasound system applied to the capillary tube.

  -With this capillary system, high precision is obtained in the dripping of the liquid, enabling the use of low concentrations of hydrogen peroxide. This system is 90% to 40%, 40% to 30%, 30% depending on the set of capillaries attached to the vaporizer / mixer with hydrogen peroxide (or other combination of chemicals) as humidifier 20%, 20% to 10%, 10% to 5%, 5% to 1% concentrations may be used.

  It is possible to associate an adjustable dosing system (13B) with one of the capillary tubes. After refilling the adjustable dose section (13B), the valve (13A) is closed and the vaporizer inlet valve (13E) is opened to allow the liquid in the adjustable dose section (13B) to Lead to vaporizer / mixer (4G) through 4D).

  When the pressure in the vaporizer then builds up, in the vaporizer / mixer (4G), it will reach less than 100 mbar in the case of the sterilization method or atmospheric pressure in the case of the sterilization method.

  -The vaporizer / mixer (4G) of the present invention is physically open to the sterilization / disinfection chamber (1) and there is no valve between the vaporizer / mixer (4G) and the chamber. Control takes place through the vaporizer inlet valve (4E, 13E) at the inlet of the capillary applied to the vaporizer / mixer, said valve being calculated by the computer based on the values measured by the various sensors (4B) It is controlled.

  In the invented device, the vaporizer / mixer (4G) and the dosing system are capable of vaporizing chemical mixtures for indoor disinfection (indoor or in a chamber) on their own. Control is based on ambient temperature and / or relative humidity and concentration of chemicals in the environment.

  -A control system is a capillary that carries a mixture of ozone and chemicals based on the pressure and / or relative humidity and / or temperature of the sterilization / disinfection chamber, the injected amount of ozone or the mixture of chemicals to the sterilization / disinfection chamber ( Control the number of open vaporizer / mixer valves (4E, 4H, and 13E) in 4D). Produce a mixture that interacts at the temperature in the chamber to achieve sterilization / disinfection; the amount of ozone contained in the chamber depends on the type of cycle, the capillary used, and the mixture of chemicals used Trigger chamber pressure fluctuations from 0 mbar to 10 mbar, 10 mbar to 100 mbar, 100 mbar to 200 mbar, 200 mbar to 500 mbar, 500 mbar to 800 mbar.

  The invention will now be described by way of non-limiting example with reference to the accompanying drawings.

FIG. 1 shows an apparatus plan that enables the achievement of the sterilization / disinfection method according to the invention. In this figure, the configuration of the device of the invention is identified by the following reference symbols: 1-sterilization / disinfection chamber 1A-chamber heater 1B-chamber sensor 2-clean side door 2A-clean side door heater 2B-clean side door sensor 3-non clean side door 3A-non clean side door heater 3 B-non clean side door Sensor 4-vaporizer / mixer 4A-vaporizer / mixer heater 4B-vaporizer / mixer sensor 4C-filter 4D-capillary tube 4E-vaporizer / mixer inlet valve 4F-PTFE junction 4G-vaporizer / Mixer chamber 4H-vaporizer / mixer inlet valve for ozone 4I-ultrasonic system 4J-microwave system 5-dosing peristaltic pump 6-chemical product tank 6A-level sensor 6B-level float 6C-tank sensor 6D-temperature control vessel Knitted 6E-Peltier plate 6F-tank 7-filled peristaltic pump 8-feed system 8A-drawer 8B-recognition sensor 8C-perforation cylinder 8D-perforation needle 8E-drawer cylinder 8F-bactericidal bottle / container with recognition system 8G-re Refill bottle / container holder 9-Plasma generator unit 9A-High voltage unit 9B-Discharge valve 9C-Plasma generator chamber 9D-High voltage electrode 9E-Temperature sensor 10-Vacuum assembly with controlled temperature and heating / cooling system 10A-vacuum pump 10B-oil separator 10C-odor filter 10D-condenser 10E-air valve 10F-air inlet 10G-control unit 10H-oil pump 10I-radiator 10J-ventilator / fan 10L-drainage 10M -Sensor 10N-Exhaust heat unit 10O-Liquid storage unit 10P-Motor 10Q-Membrane 11A-Ventilation valve 11B-Ventilation filter 11C-Transducer 12-Ozone generator unit 12A-Connection part of ozone to vaporizer 12B-Ozone generation 12C-air inlet filter 12D-control board 12E-electrical connection 13-adjustable dosing system 13A-adjustable dosing valve 13B-adjustable dosing part 13C-filter 13E-vaporizer / mixer inlet valve The configuration of the supply system is shown in detail. The configuration is identified by the following symbols: 8A-Drawer 8B-Recognition sensor 8C-Perforated cylinder 8D-Perforated needle 8E-Drawer cylinder 8G-Refilling bottle / container holder 8H-Control board 5 is a graph representing the principle of operation of the device with time evolution of pressure in the vaporizer.

DETAILED DESCRIPTION Referring to FIG. 1a, the delivery system (8) (shown in more detail in FIG. 1b) includes a drawer (8A), a restocking sensor (8B), a perforated cylinder (8C), a needle (8D). , Drawer cylinder (8E), refilling bottle / container (8F) including RFID, TAG, or microchip, bottle / container holder (8G), and control board (8H). The drawer in which the chemical product restocking unit is placed is recognized by RFID, TAG, or microchip identification, and then it is recognized by a manual or mechanical system or an electric and / or pneumatic cylinder mechanism (8E). Operate. After restocking recognition, the automation system prints restocking data by the system printer and / or stores the data in the system computer.

  After the system screen shows that there is a lack of liquid in the tank (6F), a command from the operator initiates the recharging procedure. The drawer (8A) opens and the operator is warned on the screen to remove the refill bottle / container cap before placing it in the holder (8G). The holder (8G) is designed to keep the bottle / container (8F) in an inclined position, which allows the piercing needle (8D) to reach the bottom of the bottle / container (8F), Thereby, the whole amount of liquid is taken out.

  A recognition sensor (8B) mounted under the bottle / container holder (8G) reads the RFID, TAG, or microchip, approves chemical restocking, and guarantees an efficient sterilization / disinfection cycle Used according to the manufacturer's instructions.

  After restocking is recognized and approved, the drawer (8A) is closed and the needle (8D) pierces the refilling section. The needle is actuated by a manual and / or mechanical and / or electrical and / or pneumatic system (8C). After drilling of the bottles / containers and / or other things, the chemical is pumped up by the filling pump (7) and controlled to a temperature of -10 ° C to 30 ° C by the ventilator and Peltier plate assembly (6D and 6E) Is put into the tank (6F)

  Chemical products are withdrawn from the tank (6F) by the dosing pump (5) and liquid passes through one of the three paths of the evaporation valve (4E, 13A or 13E) for air removal of the tube Return to the tank. The chemical is then introduced into one of the vaporizer / mixer capillary tubes (4D). Ozone enters the vaporizer / mixer through the valve (4H) connected to the capillary (4D) and is blended with the chemical product. Next, the mixture is diffused into the sterilization / disinfection chamber (1). The chemical product tank (6F) comprises a system that controls the float (6B) and interacts with the computer or control unit to prevent the cycle from starting when there is no chemical product in the tank. The level of chemical products is controlled by a level or pressure sensor (6A) that sends information to the computer.

  The method also includes a tunable administration system (13) that allows regulation of the prescribed administration of a particular chemical product. When using the vaporizer inlet valve (13E), the computer system instructs the dosing peristaltic pump (5) to start pumping chemical products from the tank (6F). The adjustable dosing valve (13A) opens. The liquid passes upwardly through these valves to the adjustable dose (13B) for a period of time until it is ensured that air has been completely removed from the interior of the adjustable dose. After this period, the adjustable dosing valve (13A) is closed and the dosing peristaltic pump (5) is shut off. The vaporizer / mixer inlet valve (13E) is then controlled by the computer system via pressure and / or temperature and / or humidity and / or concentration information provided by the vaporizer / mixer sensor (4B) Start to pulsate and introduce the chemical product into the vaporizer / mixer (4G) dropwise through the capillary tube (4D).

  Vaporizing and compounding chemical agent agents drop by drop with ozone is achieved by new equipment, which is heated by automatic and / or electric heating system (4A) and / or by microwave system (4J) Contains a vaporizer / mixer (4G) and contains therein a capillary tube (4D) that is calibrated and adjusted to the type of cycle being developed. The moisturizing fluid is supplied by the dosing pump (5).

  As vaporization is added dropwise for humidification and combined with ozone, it is possible to administer less steamy mixtures / formulations from the vaporizer chamber (4G) to the sterilization / disinfection chamber (1) Is controlled by the opening of the valve (4E, 4H and 13E).

  With said mixtures / formulations and evaporation methods, for materials wrapped in cellulose-based plain paper, cellulosic-based plain paper itself, or materials made of synthetic fibers, furthermore polypropylene, polyethylene or polyethylene-based packaging products, or for sterile packaging It is possible to sterilize / disinfect other synthetic resin fibers.

  The method consists of a “PCD” inside or “PCD” consisting of a flexible tube with a length of 15 meters and a diameter of 1 mm and with a location for biological indicators near the longitudinal center One (or with or without a sanitary barrier) heated to 20 ° C. to 130 ° C. to achieve biological kill, inside a rigid stainless steel tube less than 5000 mm and greater than 0.5 mm in diameter Deployed inside a sterilization / disinfection chamber (1) with two doors.

  This vaporizer / mixer is basically based on a chamber (4G) provided with a heating system (4A and / or 4J), said heating system comprising continuous pressure and / or humidity and / or temperature and / or temperature and / or Or after calculation of mixture concentration, have programming commands to control the open / close of the vaporizer / mixer inlet valves (4E, 4H and 13E). Between the chemical product inlet valve (4E or 13E) and the vaporizer / mixer chamber (4G) there is a capillary tube (4D) designed for drop evaporation. The dosing is ensured by electrical valves (4E, 4H) at the inlet of the capillary tube (4D) of the vaporizer / mixer and controlled by a computer or control unit. In the case of using the adjustable administration part (13B), the administration is not performed by the valve (13E) but by the whole liquid in the adjustable administration part (13B).

  The capillary tube (4D) can be heated by a vaporizer / mixer (4G) and then vaporized chemical product formulations drop wise to make a sterilization / disinfection formulation. The method is computer controlled and programmed.

  The vaporizer / mixer (4G) is heated at a temperature of 5 ° C. to 200 ° C. by means of an automatic and / or electric heating system (4A) applied to the vaporizer chamber and / or by means of a microwave system (4J) Be done. An ultrasound system (4I) applied to the capillary tube can also be used to improve the vaporization. The vaporizer / mixer (4G) has a pressure and / or temperature and / or humidity and / or concentration sensor (4B) which sends information to the control computer. Chemical products are dropped into the vaporizer / mixer (4G) and mixed with ozone that also enters the vaporizer / mixer (4G) through a capillary tube (4D) controlled by an electric valve (4H) Be done.

  The vaporizer / mixer is mechanically connected to the sterilization / disinfection chamber (1) by a clamp system having a PTFE tube (4F), said PTFE tube (4F) comprising a chemical product composition in gaseous state Transport to the best state sterilization / disinfection chamber (1).

  Between the dosing pump (5) and the vaporizer / mixer valves (4E, 13A, and 13E), for removing air from the tube of the injection circuit of the chemical in the drop vaporizer / mixer (4G) There is a return line of chemical products. The filter (4C) can ensure that no particles or residues reach the capillary tube (4D).

  Near the exhaust valve (9B) of the chamber (1), there is a vacuum pump (10A) air removal system that removes air before starting drop injection in the vaporizer / mixer (4G). A plasma generator (9C) having a high voltage electrode (9D) that catalyzes a mixture of chemicals and ozone at the chamber outlet and decomposes the formulation into water, oxygen and free radicals by plasma effect, a sterilization / disinfection chamber The gas coming out of (1) passes. The plasma generator may or may not be an integral part of the chamber. When using flammable chemicals, a liquid ring vacuum pump may be used.

  The sterilization / disinfection chamber (1) and the doors (2 and 3) have pressure and / or temperature and / or humidity and / or concentration sensors (11C and 1B, 2B, 3B) that inform the computer controlling the method. The

  According to FIG. 1a, in order to achieve drop injection, the capillary tube (4D) is 5 mm to 5500 mm in length, has a hole of 1 μm to 10 mm, and drops with the required accuracy for compounding chemical products Allow vaporization. The inlet valves (4E, 4H and 13E) are controlled based on the values vaporized when each is open. There may be continuous opening of the valve until a predetermined pressure value of 0.0001 mbar to 3000 mbar ABS is reached inside the sterilization / disinfection chamber.

  The dosing system has no air, which means that for the same pressure value, less material needs to be able to be injected if less material is in the chamber. On the other hand, if there are more material in the chamber for the same pressure value, it may be necessary to inject more germicide / disinfectant. This occurs due to the possibility of condensation of the sterilizing / disinfecting agent in the chamber. The charge in the chamber is preheated before starting the injection.

Sterilization / disinfection may be, for example, a biological that contains Geobacillus stearothermophilus inserted into the lumen with a population of ≧ 1.0 × 10 ⁶ in a diffusion period of 10-12.000 seconds. A lumen with a length of 15 meters with an indicator and a diameter of 1 mm is achieved.

  A peristaltic pump (5), located between the chemical tank (6F) and the vaporizer / mixer (4G), which starts to pump out 1 to 855 seconds before injection and removes all air in the tube Others ensure the instillation system. After this displacement period and the removal of air from the tubes, the vaporizer / mixer valves (4E and 13E) are used to control the pressure and / or temperature and / or temperature and / or humidity and / or concentration in the sterilization / disinfection chamber (1) Open with intermittent opening controlled by reading.

  With this method, a vaporization curve exists with an input similar to that shown in FIG. A diffusion period occurs in 10 to 12000 seconds at a pressure of 0.0001 mbar to 3000 mbar ABS and the sterilization / disinfection starts in a time frame of 10 to 12000 seconds until the proper amount of chemical composition in the chamber is reached.

  The device according to the invention is, in particular, the sterilization of cork in combination with oral material in small-sized chambers, endoscopes and videoendoscopes, corks commonly used in wine bottles, laminated corks and other products and / Or suitable for disinfection.

  The device also presents a germicidal / disinfective penetration test cycle and a leak test cycle which may be independent or simultaneous.

The device may be ozone combined with hydrogen peroxide, acetic acid, peracetic acid, water, formaldehyde or formaldehyde containing water, or any other chemical product acting at the DNA or RNA level, the product itself or a combination of these, or Chemical products such as hydrogen peroxide, acetic acid, peracetic acid, water, formaldehyde or formaldehyde containing water, or other chemical products that act at the DNA or RNA level, products that do not contain ozone themselves or products that combine them, or water Resistometer for evaluating biological and / or chemical indicators for laboratory studies of biological death using propylene oxide formulated with water or ethylene oxide formulated with water as a disinfectant / disinfectant Perform the functions of the above (the above-mentioned It will be understood that may be used in the form of a formulation as is).

  An advantage of the multicapillary vaporizer / mixer is that, when applied for use at atmospheric pressure, the various products can be accurately reblended to obtain sterilization / disinfection or environmental disinfection. By mixing / blending hydrogen peroxide and ozone, lower concentrations of hydrogen peroxide or others are used, thereby reducing the corrosiveness of the sterilizing / disinfecting agent in the chamber and maintaining the efficiency of the method While providing the ability to turn the equipment to be disinfected or disinfected into an environmentally friendly method that is not damaged.

  On the other hand, low concentrations of chemicals allow its optimization in each cycle and improve the decomposition of the chemicals in the plasma generator (9C). Therefore, after the chemical passes through the molecular sieve (10 C), it is less than 1 ppm at the outlet of the outlet.

  Modifications to the disclosed sterilization / disinfection apparatus are possible while maintaining the working principles set forth in the appended claims, for example, modifications using equivalent elements within the scope of the present invention.

  Also, other chemical products may be combined with the chemical products claimed in the present patent application.

Claims (16)

An ozone sterilization or disinfection apparatus with a chemical vapor inlet, hydrogen peroxide through multicapillary tubes (4D) in the vaporizer / mixer (4G) supplying the sterilization / disinfection chamber (1), Does the ozone be vaporized and combined with acetic acid, peracetic acid, water, formaldehyde or formaldehyde containing water, or other chemical products, the delivery being performed in a dosing unit which varies depending on the control performed by the computer or control unit Or adjustable dosing unit (13B); said vaporizer / mixer is at a pressure below atmospheric pressure, by automatic and / or electric system (4A) or by microwave system (4J) 5 Operated by heating at a temperature of 200 ° C to 200 ° C; evaporation method is vacuum to the sterilization / disinfection chamber (1) Or at atmospheric pressure, at a pressure of 0.0001 mbar to 3000 mbar ABS; filling of the chemical products supplied from the tank (6F) is performed drop-wise with a capillary tube (4D) at a controlled temperature, and the liquid is sprayed gas Said computer controls the electrical valves (4E and 4H) following the dosing pump (5) and the ozone generator (12B) including the control board (12D) and the air inlet filter (12C) Considering the pressure and / or temperature and / or information on temperature and / or humidity and / or concentration given by (IB, 2B, 3B, 4B, and 11C), the pressure inside the sterilization / disinfection chamber (1) can be Maintain a certain predetermined value during the sterilization or disinfection method; if the device has a heat removal system (10 N), Temperature control sensor (10M) as well as air valve heating system (10E) and cooling system consisting of oil pump (10H), radiator (10I), fan (10J), and electric control unit (10G) Membrane (10Q) for separating water from oil, drain system (10L), liquid reservoir (10O), oil separator (10B) connected to air inlet (10F), comprising vacuum pump (10A), And a large volume of molecular sieve (10C); at the discharge stage, the high voltage part (9A) applied to the electrode (9D) activates the plasma generator (9C) to generate plasma, The temperature of the plasma generator is monitored by a sensor (9E); said device is an automatic supply system and is attached to the holder (8G) The sterilizing agent is taken out of the toll / container (8F), the holder (8G) holds the bottle / container (8F) in the inclined position, and the perforated needle (operated by the servomotor (8C) by the inclined position) 8D) allowing the bottom of the bottle / container to reach, thus removing the entire liquid, recognizing the resupply by RFID, TAG, or microchip, PC where data is printed after refilling A drawer (8A) having a refilling recognition sensor (8B) for sending refilling data to the device, said automatic feeding system being operated automatically by a servomotor (8E); the refilling system comprises various chemistries A device capable of supplying products, characterized in that said various chemical products are automatically recognized and pumped into corresponding tanks .   The vaporization can be increased by an ultrasound system (4I) at the inlet of the capillary tube (4D) or by a microwave system (4J) applied to the vaporizer chamber (4G) The apparatus according to item 1. The apparatus comprises pressure and / or temperature and / or humidity and / or concentration sensors, ie in the vaporizer / mixer (4G), in the tank (6F) of the chemical product, and in the sterilization / disinfection chamber (1 The ozone generator (12B), ozone is compounded through the capillary in the vaporizer / mixer (4G) and injected into the chamber. An apparatus according to item 1 or 2. The device according to claim 1, characterized in that said vaporizer / mixer (4G) is mechanically connected to said sterilization / disinfection chamber (1) by a clamp system or other and a tube of PTFE (or other suitable material). An apparatus according to any one of Items 1 to 3. 5. Device according to claims 1-4, characterized in that the sterilization / disinfection chamber (1) comprises a vacuum pump (10A). An air removal system characterized in that it comprises an air removal system close to the inlet valve (4E and 13E) of the vaporizer and through a tube returning to the tank (6F) controlled by the computer system. The apparatus as described in 1-5. 7. Device according to claims 1 to 6, characterized in that it comprises molecular sieves (10C) at the end of the discharge line holding any final residue. The device according to claims 1 to 7, characterized in that it comprises a multicapillary tube (4D) having a length of 5 mm to 5500 mm and having holes of 1 μm to 10 mm. The vaporizer / mixer (4G) vaporizes about 0.01 to 1000 ml of hydrogen peroxide or other chemicals from one of the tanks (6F) or from the adjustable dosing section (13B) An apparatus as claimed in any one of the preceding claims, which is combined with ozone for a period of about 1 to 1000 seconds and injected into the sterilization / disinfection chamber (1) whose pressure reaches a value of about 0.0001 to 3000 mbar ABS. A sterilization method characterized in that The sterilization / disinfection after the vaporizer / mixer (4G) is heated to a temperature of 5 ° C. to 200 ° C. by an automatic and / or electrical heating system (4A) or by a microwave system (4J) 10. Sterilization according to claim 9, characterized in that said hydrogen peroxide or other chemical vapor reformed in the injection of ozone into the chamber (1) occurs at a temperature value of between 20 <0> C and 130 <0> C. Method. The hydrogen peroxide or other chemical is dripped into the vaporizer / mixer (4G) to create a moist atmosphere mixed with ozone and drop injection starts in the vaporizer / mixer (4G) Air from the chamber (1) and the vaporizer / mixer (4G) prior to and before injecting ozone through the valve (4H) and diffusing into the sterilization / disinfection chamber (1) 11. The method according to claims 9 and 10, characterized in that it comprises a vacuum pump (10A) to evacuate. The discharge of the mixture in the sterilization / disinfection chamber (1) passes through the heated tube (10N), the heating system by the air valve (10E), as well as the radiator (10I), the ventilator / fan (10J), And cooling system with set of oil pump (10H) and vacuum with removal system of membrane (10Q), waste liquid valve (10L), and control unit (10G) storing control unit (10G) storing aqueous liquid in reservoir (10O) While the hydrogen peroxide or other chemicals mixed / blended with the ozone are removed from the chamber (1) and made by the pump (10A), a plasma generator with high voltage electrode (9D) ( 9C), the hydrogen peroxide or other chemicals and ozone are free from water, oxygen and free by plasma effect. Characterized in that it is decomposed into radical, sterilization method of claim 9-11. A multicapillary tube (4D) injects hydrogen peroxide or other chemicals drop-wise into the vaporizer / mixer (4G), injects ozone, and the liquid vaporizer inlet valves (4E and 13E) Through the capillary controlled by the valve; the valve is controlled based on the value of the vaporized mixture / formulation at each opening, until the pressure of 0.0001 mbar to 3000 mbar ABS is obtained, the valves (4E and 13E A continuous release of hydrogen peroxide), ozone can be vaporized with chemical products such as hydrogen peroxide, acetic acid, peracetic acid, water, formaldehyde or formaldehyde containing water, or other chemical products. The sterilization method as described in 9-12. Chemical compound penetration test cycle; leak test cycle, cycle that incorporates the penetration test and leak test into a single test, and the limit that the PLC can manage pressure fluctuations and the endoscope can beat up A flexible endoscopic cycle controlled by an automatic system to maintain pressure fluctuations therein, thereby reducing pressure fluctuations between the inner and outer portions of the endoscope; 14. A method according to any one of claims 9 to 13, characterized in that cycles are dedicated to different capillaries in different mixers and different materials based on different capillary tubes. A device according to claims 1-8 and a method according to claims 9-14, characterized in that it is applied to the environmental disinfection of a room or a chamber by vaporizing ozone or a combination of other chemicals. Use of. The use of the device according to claims 1-8 and the method according to claims 9-14, characterized in that said device performs the function of a resist meter.

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