JP6417338B2 - 癌の治療のためのｍｄｍ２阻害剤としてのシス−モルホリノン及び他の化合物 - Google Patents

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Publication number

JP6417338B2

JP6417338B2 JP2015558205A JP2015558205A JP6417338B2 JP 6417338 B2 JP6417338 B2 JP 6417338B2 JP 2015558205 A JP2015558205 A JP 2015558205A JP 2015558205 A JP2015558205 A JP 2015558205A JP 6417338 B2 JP6417338 B2 JP 6417338B2

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JP

Japan

Prior art keywords

chlorophenyl

morpholinyl

oxo

bis

acid

Prior art date

2013-02-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 150000001875 compounds Chemical class 0.000 title claims description 226
• 206010028980 Neoplasm Diseases 0.000 title description 57
• 201000011510 cancer Diseases 0.000 title description 33
• 238000011282 treatment Methods 0.000 title description 17
• 239000012819 MDM2-Inhibitor Substances 0.000 title description 4
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 515
• 235000011054 acetic acid Nutrition 0.000 claims description 172
• 229960000583 acetic acid Drugs 0.000 claims description 172
• -1 (4-chlorophenyl) -4- (cyclopropylmethyl) -2- (3-hydroxypropyl) morpholin-3-one Chemical compound 0.000 claims description 145
• IPWFJLQDVFKJDU-UHFFFAOYSA-N pentanamide Chemical compound CCCCC(N)=O IPWFJLQDVFKJDU-UHFFFAOYSA-N 0.000 claims description 121
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 51
• 125000000217 alkyl group Chemical group 0.000 claims description 50
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 47
• 150000003839 salts Chemical class 0.000 claims description 46
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 45
• 125000001072 heteroaryl group Chemical group 0.000 claims description 41
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 40
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 36
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 36
• 125000003118 aryl group Chemical group 0.000 claims description 34
• 229910052739 hydrogen Inorganic materials 0.000 claims description 30
• 239000001257 hydrogen Substances 0.000 claims description 30
• NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 28
• 125000005843 halogen group Chemical group 0.000 claims description 26
• 229940000635 beta-alanine Drugs 0.000 claims description 24
• 239000002253 acid Substances 0.000 claims description 23
• 125000005842 heteroatom Chemical group 0.000 claims description 22
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
• ZMSIFDIKIXVLDF-UHFFFAOYSA-N 2-methyl-1,3,4-oxadiazole Chemical compound CC1=NN=CO1 ZMSIFDIKIXVLDF-UHFFFAOYSA-N 0.000 claims description 19
• 125000001424 substituent group Chemical group 0.000 claims description 19
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 18
• 239000004471 Glycine Substances 0.000 claims description 18
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 18
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 18
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 16
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 16
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 14
• 229910052757 nitrogen Inorganic materials 0.000 claims description 12
• 229910052760 oxygen Inorganic materials 0.000 claims description 10
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
• MYDQAEQZZKVJSL-UHFFFAOYSA-N pentyl carbamate Chemical compound CCCCCOC(N)=O MYDQAEQZZKVJSL-UHFFFAOYSA-N 0.000 claims description 9
• PLSLYOZGYCPTIL-TYPHKJRUSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 PLSLYOZGYCPTIL-TYPHKJRUSA-N 0.000 claims description 8
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
• SBIUCEQISUZNJO-CAOCKLPOSA-N (2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(2-morpholin-4-yl-2-oxoethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CC2)C(=O)[C@H](CC(=O)N2CCOCC2)O[C@H]1C1=CC=CC(Cl)=C1 SBIUCEQISUZNJO-CAOCKLPOSA-N 0.000 claims description 7
• 239000008194 pharmaceutical composition Substances 0.000 claims description 7
• MURGPOPKNPYXAX-HVWQDESWSA-N (2R)-2-[(2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound ClC1=CC=C(C=C1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)[C@@H](C(=O)O)C1CC1)=O)CC1=CC=C(C=C1)C#N MURGPOPKNPYXAX-HVWQDESWSA-N 0.000 claims description 6
• MURGPOPKNPYXAX-LGTXBLIGSA-N (2S)-2-[(2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound ClC1=CC=C(C=C1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)[C@H](C(=O)O)C1CC1)=O)CC1=CC=C(C=C1)C#N MURGPOPKNPYXAX-LGTXBLIGSA-N 0.000 claims description 6
• MURGPOPKNPYXAX-YAOOYPAMSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@H](C(=O)O)N2C([C@H](CC=3C=CC(=CC=3)C#N)O[C@H]([C@H]2C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=O)CC1 MURGPOPKNPYXAX-YAOOYPAMSA-N 0.000 claims description 6
• BPTXICQAEGSTHS-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 BPTXICQAEGSTHS-ZJSPYRCASA-N 0.000 claims description 6
• MURGPOPKNPYXAX-XUJYPJAKSA-N (2s)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@@H](C(=O)O)N2C([C@H](CC=3C=CC(=CC=3)C#N)O[C@H]([C@H]2C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=O)CC1 MURGPOPKNPYXAX-XUJYPJAKSA-N 0.000 claims description 6
• YYVYIVSNIAMIER-ZRBLBEILSA-N (2s,5r,6s)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=CC=C1 YYVYIVSNIAMIER-ZRBLBEILSA-N 0.000 claims description 6
• PLSLYOZGYCPTIL-HLAWJBBLSA-N 2-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 PLSLYOZGYCPTIL-HLAWJBBLSA-N 0.000 claims description 6
• 125000000979 2-amino-2-oxoethyl group Chemical group [H]C([*])([H])C(=O)N([H])[H] 0.000 claims description 6
• NHDJKSJILSOCFS-RLLQIKCJSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NHDJKSJILSOCFS-RLLQIKCJSA-N 0.000 claims description 5
• WDHFWCFVVPABNM-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(3-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(F)=C1 WDHFWCFVVPABNM-ZJSPYRCASA-N 0.000 claims description 5
• SOTSYTXAFGARSV-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1 SOTSYTXAFGARSV-RAVGUYNFSA-N 0.000 claims description 5
• YYVYIVSNIAMIER-XPWALMASSA-N (2r,5s,6r)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=CC=C1 YYVYIVSNIAMIER-XPWALMASSA-N 0.000 claims description 5
• NNHHVXDUFOZJBY-BHIFYINESA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]morpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@@H]1C(=O)N[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 NNHHVXDUFOZJBY-BHIFYINESA-N 0.000 claims description 5
• VPGKHHKAWPXNLG-VJGNERBWSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-pyridin-4-ylmorpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@H]1C(=O)N(C=2C=CN=CC=2)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 VPGKHHKAWPXNLG-VJGNERBWSA-N 0.000 claims description 5
• USNQYGDSTBFBSK-UXHICEINSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CC2)C(=O)CO[C@H]1C1=CC=CC(Cl)=C1 USNQYGDSTBFBSK-UXHICEINSA-N 0.000 claims description 5
• USNQYGDSTBFBSK-VQTJNVASSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(CC2CC2)C(=O)CO[C@@H]1C1=CC=CC(Cl)=C1 USNQYGDSTBFBSK-VQTJNVASSA-N 0.000 claims description 5
• GOJFTLJDUNFYCJ-ZSXPUABSSA-N 2-[(2r,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2s)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C([C@@H](CC(O)=O)O2)=O)[C@H](CO)CC)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 GOJFTLJDUNFYCJ-ZSXPUABSSA-N 0.000 claims description 5
• GOJFTLJDUNFYCJ-MMKMLUHNSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2s)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CC(O)=O)O2)=O)[C@H](CO)CC)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 GOJFTLJDUNFYCJ-MMKMLUHNSA-N 0.000 claims description 5
• RIKDLQRVZMFAOC-SXWPHCFWSA-N C(C)=O.ClC=1C=C(C=CC1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)CC1CC1)=O)CC=O Chemical compound C(C)=O.ClC=1C=C(C=CC1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)CC1CC1)=O)CC=O RIKDLQRVZMFAOC-SXWPHCFWSA-N 0.000 claims description 5
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 5
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
• YFIAXOHWIQXCTA-KAGYGMCKSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2N(C(CO[C@]2(C)C=2C=CC(Cl)=CC=2)=O)[C@H](CCC)C(O)=O)=CC=C(Cl)C=C1 YFIAXOHWIQXCTA-KAGYGMCKSA-N 0.000 claims description 4
• YEWIXZBJFKGKIX-YFNKSVMNSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-3-phenylpropanoic acid Chemical compound C([C@H](C(=O)O)N1C(CO[C@@H]([C@@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)C1=CC=CC=C1 YEWIXZBJFKGKIX-YFNKSVMNSA-N 0.000 claims description 4
• KGYXFUQDTGFHHL-HLAWJBBLSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 KGYXFUQDTGFHHL-HLAWJBBLSA-N 0.000 claims description 4
• VVXLJODXWXBXLX-XUVXKRRUSA-N (2r)-2-[(2r,3s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@H](C(=O)O)N2C(CO[C@@H]([C@@H]2C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)=O)CC1 VVXLJODXWXBXLX-XUVXKRRUSA-N 0.000 claims description 4
• HQRAQGJHPUFZPL-BAGYTPMASA-N (2r)-2-[(2r,3s)-2-(4-chlorophenyl)-3-(1h-indol-2-yl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2NC3=CC=CC=C3C=2)=CC=C(Cl)C=C1 HQRAQGJHPUFZPL-BAGYTPMASA-N 0.000 claims description 4
• YFIAXOHWIQXCTA-UZKOGDIHSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2N(C(CO[C@@]2(C)C=2C=CC(Cl)=CC=2)=O)[C@H](CCC)C(O)=O)=CC=C(Cl)C=C1 YFIAXOHWIQXCTA-UZKOGDIHSA-N 0.000 claims description 4
• YEWIXZBJFKGKIX-JRFVFWCSSA-N (2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-3-phenylpropanoic acid Chemical compound C([C@H](C(=O)O)N1C(CO[C@H]([C@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)C1=CC=CC=C1 YEWIXZBJFKGKIX-JRFVFWCSSA-N 0.000 claims description 4
• VVXLJODXWXBXLX-AQNXPRMDSA-N (2r)-2-[(2s,3r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@H](C(=O)O)N2C(CO[C@H]([C@H]2C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)=O)CC1 VVXLJODXWXBXLX-AQNXPRMDSA-N 0.000 claims description 4
• DELFMJQSZBLXHR-RLLQIKCJSA-N (2r)-2-[(2s,3r)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 DELFMJQSZBLXHR-RLLQIKCJSA-N 0.000 claims description 4
• YVJUKVSHQAHNBQ-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-5-oxo-6-[[4-(trifluoromethylsulfonyl)phenyl]methyl]morpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(=O)(=O)C(F)(F)F)C=C1 YVJUKVSHQAHNBQ-ZJSPYRCASA-N 0.000 claims description 4
• LSNLEJWOTADEBZ-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(3-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(S(C)(=O)=O)=C1 LSNLEJWOTADEBZ-RAVGUYNFSA-N 0.000 claims description 4
• AKVZPAVYTSBNGJ-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 AKVZPAVYTSBNGJ-RAVGUYNFSA-N 0.000 claims description 4
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• IRPCEHWYFCBCLC-VJLURNNQSA-N (2r)-3-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NC[C@@H](NC(=O)OC(C)(C)C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 IRPCEHWYFCBCLC-VJLURNNQSA-N 0.000 claims description 4
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• NGKDSMRXYILHBJ-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-(3-morpholin-4-ylpropyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CCN1CCOCC1 NGKDSMRXYILHBJ-ZJSPYRCASA-N 0.000 claims description 3
• LBKMRYPTFPFDCU-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(2-cyano-4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1C#N LBKMRYPTFPFDCU-RAVGUYNFSA-N 0.000 claims description 3
• PWBYWLZBUHMMDL-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(2-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1C#N PWBYWLZBUHMMDL-RAVGUYNFSA-N 0.000 claims description 3
• AMKMOSMZFSCUOD-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(2-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1F AMKMOSMZFSCUOD-ZJSPYRCASA-N 0.000 claims description 3
• PEUMHKJNNDMFQQ-PTJMHOJZSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(2-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1S(C)(=O)=O PEUMHKJNNDMFQQ-PTJMHOJZSA-N 0.000 claims description 3
• SPYIFURQACUIAM-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(3-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(C#N)=C1 SPYIFURQACUIAM-RAVGUYNFSA-N 0.000 claims description 3
• AHQBKWGBBRACRW-PTJMHOJZSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(3-fluoro-4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C(F)=C1 AHQBKWGBBRACRW-PTJMHOJZSA-N 0.000 claims description 3
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• IRPCEHWYFCBCLC-IUHCWXKNSA-N (2r)-3-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NC[C@@H](NC(=O)OC(C)(C)C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 IRPCEHWYFCBCLC-IUHCWXKNSA-N 0.000 claims description 3
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• FFWXYSDZASUBHP-XPWALMASSA-N (2r,5s,6r)-2-benzyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=CC=C1 FFWXYSDZASUBHP-XPWALMASSA-N 0.000 claims description 3
• FCOPQZKTHYVUEK-TZRRMPRUSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-2-[(3-methoxyphenyl)methyl]-4-methylmorpholin-3-one Chemical compound COC1=CC=CC(C[C@@H]2C(N(C)[C@H]([C@H](O2)C=2C=CC(Br)=CC=2)C=2C=CC(Br)=CC=2)=O)=C1 FCOPQZKTHYVUEK-TZRRMPRUSA-N 0.000 claims description 3
• ZOPUXVMFTFLAOX-XPWALMASSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-2-[(4-fluorophenyl)methyl]-4-methylmorpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=C(F)C=C1 ZOPUXVMFTFLAOX-XPWALMASSA-N 0.000 claims description 3
• JQFPMGMYKYPPLI-TZRRMPRUSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-2-[(4-methoxyphenyl)methyl]-4-methylmorpholin-3-one Chemical compound C1=CC(OC)=CC=C1C[C@@H]1C(=O)N(C)[C@@H](C=2C=CC(Br)=CC=2)[C@@H](C=2C=CC(Br)=CC=2)O1 JQFPMGMYKYPPLI-TZRRMPRUSA-N 0.000 claims description 3
• HYNGBJAFVPKRRJ-XPWALMASSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-4-methyl-2-[[4-(trifluoromethoxy)phenyl]methyl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=C(OC(F)(F)F)C=C1 HYNGBJAFVPKRRJ-XPWALMASSA-N 0.000 claims description 3
• TWSBSLQNMNNFDV-OZNIXHKMSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-phenylmorpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@@H]1C(=O)N(C=2C=CC=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 TWSBSLQNMNNFDV-OZNIXHKMSA-N 0.000 claims description 3
• ZOHISOPDHUSNHZ-OZNIXHKMSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-methylsulfonylphenyl)methyl]-4-pyridin-3-ylmorpholin-3-one Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C[C@@H]1C(=O)N(C=2C=NC=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 ZOHISOPDHUSNHZ-OZNIXHKMSA-N 0.000 claims description 3
• ISEMFQGMTRGCLK-BHIFYINESA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-2-(2-morpholin-4-ylethyl)morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CN1CCOCC1 ISEMFQGMTRGCLK-BHIFYINESA-N 0.000 claims description 3
• OGHYKDRSHULZRE-BHIFYINESA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-2-(pyridin-4-ylmethyl)morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=NC=C1 OGHYKDRSHULZRE-BHIFYINESA-N 0.000 claims description 3
• BTFDOQOPNARQSS-QHAWAJNXSA-N (2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(2-hydroxyethyl)morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CCO)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 BTFDOQOPNARQSS-QHAWAJNXSA-N 0.000 claims description 3
• PMULZUULMROOQM-BHIFYINESA-N (2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(3-hydroxypropyl)morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CCCO)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 PMULZUULMROOQM-BHIFYINESA-N 0.000 claims description 3
• FODTWMGUVKCBDV-BHIFYINESA-N (2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[2-(methylamino)ethyl]morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CCNC)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 FODTWMGUVKCBDV-BHIFYINESA-N 0.000 claims description 3
• YFIAXOHWIQXCTA-RCZSKKKRSA-N (2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2N(C(CO[C@]2(C)C=2C=CC(Cl)=CC=2)=O)[C@@H](CCC)C(O)=O)=CC=C(Cl)C=C1 YFIAXOHWIQXCTA-RCZSKKKRSA-N 0.000 claims description 3
• NFFXQTHZDQEVMP-ZRBLBEILSA-N (2s,5r,6s)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 NFFXQTHZDQEVMP-ZRBLBEILSA-N 0.000 claims description 3
• FFWXYSDZASUBHP-ZRBLBEILSA-N (2s,5r,6s)-2-benzyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=CC=C1 FFWXYSDZASUBHP-ZRBLBEILSA-N 0.000 claims description 3
• FCOPQZKTHYVUEK-VXNXHJTFSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-2-[(3-methoxyphenyl)methyl]-4-methylmorpholin-3-one Chemical compound COC1=CC=CC(C[C@H]2C(N(C)[C@@H]([C@@H](O2)C=2C=CC(Br)=CC=2)C=2C=CC(Br)=CC=2)=O)=C1 FCOPQZKTHYVUEK-VXNXHJTFSA-N 0.000 claims description 3
• ZOPUXVMFTFLAOX-ZRBLBEILSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-2-[(4-fluorophenyl)methyl]-4-methylmorpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=C(F)C=C1 ZOPUXVMFTFLAOX-ZRBLBEILSA-N 0.000 claims description 3
• JQFPMGMYKYPPLI-VXNXHJTFSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-2-[(4-methoxyphenyl)methyl]-4-methylmorpholin-3-one Chemical compound C1=CC(OC)=CC=C1C[C@H]1C(=O)N(C)[C@H](C=2C=CC(Br)=CC=2)[C@H](C=2C=CC(Br)=CC=2)O1 JQFPMGMYKYPPLI-VXNXHJTFSA-N 0.000 claims description 3
• HYNGBJAFVPKRRJ-ZRBLBEILSA-N (2s,5r,6s)-5,6-bis(4-bromophenyl)-4-methyl-2-[[4-(trifluoromethoxy)phenyl]methyl]morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=C(OC(F)(F)F)C=C1 HYNGBJAFVPKRRJ-ZRBLBEILSA-N 0.000 claims description 3
• GAQCTUBQELXKFM-GVAUOCQISA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-(1h-pyrazol-4-yl)morpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@H]1C(=O)N(C2=CNN=C2)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 GAQCTUBQELXKFM-GVAUOCQISA-N 0.000 claims description 3
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• ZOHISOPDHUSNHZ-IARZGTGTSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-2-[(4-methylsulfonylphenyl)methyl]-4-pyridin-3-ylmorpholin-3-one Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C[C@H]1C(=O)N(C=2C=NC=CC=2)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 ZOHISOPDHUSNHZ-IARZGTGTSA-N 0.000 claims description 3
• KDMZQPXBRXKOKS-OIKPOIBNSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-(2-chloropyridin-4-yl)-2-[(4-fluorophenyl)methyl]morpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@H]1C(=O)N(C=2C=C(Cl)N=CC=2)[C@H](C=2C=CC(Cl)=CC=2)[C@H](C=2C=CC(Cl)=CC=2)O1 KDMZQPXBRXKOKS-OIKPOIBNSA-N 0.000 claims description 3
• ISEMFQGMTRGCLK-BDTNDASRSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-2-(2-morpholin-4-ylethyl)morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CN1CCOCC1 ISEMFQGMTRGCLK-BDTNDASRSA-N 0.000 claims description 3
• OGHYKDRSHULZRE-BDTNDASRSA-N (2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-2-(pyridin-4-ylmethyl)morpholin-3-one Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=NC=C1 OGHYKDRSHULZRE-BDTNDASRSA-N 0.000 claims description 3
• BTFDOQOPNARQSS-HBMCJLEFSA-N (2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(2-hydroxyethyl)morpholin-3-one Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CCO)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 BTFDOQOPNARQSS-HBMCJLEFSA-N 0.000 claims description 3
• FODTWMGUVKCBDV-BDTNDASRSA-N (2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[2-(methylamino)ethyl]morpholin-3-one Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CCNC)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 FODTWMGUVKCBDV-BDTNDASRSA-N 0.000 claims description 3
• UXPNGKJMGNJWPS-CLAROIROSA-N (2s,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(2r)-2,3-dihydroxypropyl]morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@H](C1=O)C[C@@H](O)CO)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 UXPNGKJMGNJWPS-CLAROIROSA-N 0.000 claims description 3
• VFQSDHHWNIJHMY-NRSPTQNISA-N (3r,4s,8ar)-4-(3-chlorophenyl)-3-(4-chlorophenyl)-2-propan-2-yl-4,7,8,8a-tetrahydro-3h-pyrrolo[1,2-a]pyrazine-1,6-dione Chemical compound C1([C@H]2[C@H](N(C([C@@H]3N2C(CC3)=O)=O)C(C)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 VFQSDHHWNIJHMY-NRSPTQNISA-N 0.000 claims description 3
• PTHOVXLFQNARAG-GEEWNISJSA-N (4r)-4-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]heptanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CCC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 PTHOVXLFQNARAG-GEEWNISJSA-N 0.000 claims description 3
• PTHOVXLFQNARAG-IXGYBEARSA-N (4s)-4-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]heptanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 PTHOVXLFQNARAG-IXGYBEARSA-N 0.000 claims description 3
• HVHAGGDWFLSMMK-UXHICEINSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2,2-dimethyl-1,1-dioxo-1,4-thiazinan-3-one Chemical compound O=S(=O)([C@@H](C=1C=C(Cl)C=CC=1)[C@H]1C=2C=CC(Cl)=CC=2)C(C)(C)C(=O)N1CC1CC1 HVHAGGDWFLSMMK-UXHICEINSA-N 0.000 claims description 3
• ZUYDNBDMQAEZPD-DLBZAZTESA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 ZUYDNBDMQAEZPD-DLBZAZTESA-N 0.000 claims description 3
• AXLFRXXLVUJAFX-IZZBFERCSA-N 2-[(2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxo-4-[(1S)-1-(2H-tetrazol-5-yl)butyl]morpholin-2-yl]acetic acid Chemical compound N1N=NN=C1[C@H](CCC)N1C([C@H](O[C@@H]([C@@H]1C1=CC=C(C=C1)Cl)C1=CC(=CC=C1)Cl)CC(=O)O)=O AXLFRXXLVUJAFX-IZZBFERCSA-N 0.000 claims description 3
• XKUYNNZACAGYEX-KRXUUXHPSA-N 2-[(2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(1R)-1-cyanobutyl]-3-oxomorpholin-2-yl]acetic acid Chemical compound ClC=1C=C(C=CC1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)[C@H](CCC)C#N)=O)CC(=O)O XKUYNNZACAGYEX-KRXUUXHPSA-N 0.000 claims description 3
• XKUYNNZACAGYEX-YUVXSKOASA-N 2-[(2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(1S)-1-cyanobutyl]-3-oxomorpholin-2-yl]acetic acid Chemical compound ClC=1C=C(C=CC1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)[C@@H](CCC)C#N)=O)CC(=O)O XKUYNNZACAGYEX-YUVXSKOASA-N 0.000 claims description 3
• AXLFRXXLVUJAFX-JYRKZWEQSA-N 2-[(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxo-4-[(1R)-1-(2H-tetrazol-5-yl)butyl]morpholin-2-yl]acetic acid Chemical compound N1N=NN=C1[C@@H](CCC)N1C([C@@H](O[C@H]([C@H]1C1=CC=C(C=C1)Cl)C1=CC(=CC=C1)Cl)CC(=O)O)=O AXLFRXXLVUJAFX-JYRKZWEQSA-N 0.000 claims description 3
• XKUYNNZACAGYEX-KIZRIRGWSA-N 2-[(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(1R)-1-cyanobutyl]-3-oxomorpholin-2-yl]acetic acid Chemical compound ClC=1C=C(C=CC1)[C@@H]1O[C@H](C(N([C@@H]1C1=CC=C(C=C1)Cl)[C@H](CCC)C#N)=O)CC(=O)O XKUYNNZACAGYEX-KIZRIRGWSA-N 0.000 claims description 3
• QDILNQYTSNQECW-IZZBFERCSA-N 2-[(2r,5s,6r)-4-[(2s)-1-amino-1-oxopentan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](CC(O)=O)O2)=O)[C@@H](CCC)C(N)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 QDILNQYTSNQECW-IZZBFERCSA-N 0.000 claims description 3
• FWZPXOOPTXRDSU-YFNKSVMNSA-N 2-[(2r,5s,6r)-4-benzyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1=CC=CC=C1 FWZPXOOPTXRDSU-YFNKSVMNSA-N 0.000 claims description 3
• FFLUYTXQAXBHJM-BAGYTPMASA-N 2-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclobutylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CCC1 FFLUYTXQAXBHJM-BAGYTPMASA-N 0.000 claims description 3
• VPRNCQLEQWUMOF-YFNKSVMNSA-N 2-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclohexylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CCCCC1 VPRNCQLEQWUMOF-YFNKSVMNSA-N 0.000 claims description 3
• QDILNQYTSNQECW-JYRKZWEQSA-N 2-[(2s,5r,6s)-4-[(2r)-1-amino-1-oxopentan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CC(O)=O)O2)=O)[C@H](CCC)C(N)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 QDILNQYTSNQECW-JYRKZWEQSA-N 0.000 claims description 3
• QDILNQYTSNQECW-MMKMLUHNSA-N 2-[(2s,5r,6s)-4-[(2s)-1-amino-1-oxopentan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CC(O)=O)O2)=O)[C@@H](CCC)C(N)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 QDILNQYTSNQECW-MMKMLUHNSA-N 0.000 claims description 3
• FWZPXOOPTXRDSU-QTJGBDASSA-N 2-[(2s,5r,6s)-4-benzyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1=CC=CC=C1 FWZPXOOPTXRDSU-QTJGBDASSA-N 0.000 claims description 3
• FFLUYTXQAXBHJM-NNWRFLSQSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclobutylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CCC1 FFLUYTXQAXBHJM-NNWRFLSQSA-N 0.000 claims description 3
• VPRNCQLEQWUMOF-QTJGBDASSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclohexylmethyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CCCCC1 VPRNCQLEQWUMOF-QTJGBDASSA-N 0.000 claims description 3
• KSWKEATWRRWERE-IEIRFRATSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-5-methyl-3-oxomorpholin-2-yl]acetic acid Chemical compound O=C([C@H](CC(O)=O)O[C@H]([C@@]1(C)C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)N1CC1CC1 KSWKEATWRRWERE-IEIRFRATSA-N 0.000 claims description 3
• XKUYNNZACAGYEX-MPJJRAAHSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(1s)-1-cyanobutyl]-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CC(O)=O)O2)=O)[C@H](C#N)CCC)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 XKUYNNZACAGYEX-MPJJRAAHSA-N 0.000 claims description 3
• RTDZBLVTLREENZ-BAGYTPMASA-N 3-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]propanoic acid Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CCC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 RTDZBLVTLREENZ-BAGYTPMASA-N 0.000 claims description 3
• RTDZBLVTLREENZ-NNWRFLSQSA-N 3-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]propanoic acid Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CCC(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 RTDZBLVTLREENZ-NNWRFLSQSA-N 0.000 claims description 3
• IOBJPQJJXSHZBT-HUAAZGBFSA-N 4-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]butanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NCCCC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 IOBJPQJJXSHZBT-HUAAZGBFSA-N 0.000 claims description 3
• VCHJPDFVEKENPJ-OUMDNPPYSA-N (2R)-2-[(2S,3R,6S)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-(2-morpholin-4-yl-2-oxoethyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound ClC=1C=C(C=CC1)[C@H]1[C@H](N(C([C@@H](O1)CC(=O)N1CCOCC1)=O)[C@@H](C(=O)O)CCC)C1=CC=C(C=C1)Cl VCHJPDFVEKENPJ-OUMDNPPYSA-N 0.000 claims description 2
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• YZXNLAQFGPTWEK-DMTNHVFBSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-(1-methylimidazol-4-yl)morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1C=1N=CN(C1)C)=O)CC1=CC=C(C=C1)F)C1=CC=C(C=C1)Cl YZXNLAQFGPTWEK-DMTNHVFBSA-N 0.000 claims description 2
• XBDLXEHVSZYECN-XFBWMNOSSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2S)-1-(4-methylpiperazin-1-yl)-1-oxopentan-2-yl]morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1[C@@H](CCC)C(=O)N1CCN(CC1)C)=O)CC1=CC=C(C=C1)F)C1=CC=C(C=C1)Cl XBDLXEHVSZYECN-XFBWMNOSSA-N 0.000 claims description 2
• OZZCSOBIPVVGCN-YYGZZXRFSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2S)-1-hydroxypentan-2-yl]morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1[C@@H](CCC)CO)=O)CC1=CC=C(C=C1)F)C1=CC=C(C=C1)Cl OZZCSOBIPVVGCN-YYGZZXRFSA-N 0.000 claims description 2
• XMOWLFHORUUXHL-RRGQHJHPSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2S)-1-morpholin-4-yl-1-oxopentan-2-yl]morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1[C@@H](CCC)C(=O)N1CCOCC1)=O)CC1=CC=C(C=C1)F)C1=CC=C(C=C1)Cl XMOWLFHORUUXHL-RRGQHJHPSA-N 0.000 claims description 2
• GHBPXNGRPGLEEC-XFBWMNOSSA-N (2R,5S,6R)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2S)-1-morpholin-4-ylpentan-2-yl]morpholin-3-one Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](O[C@@H](C(N1[C@@H](CCC)CN1CCOCC1)=O)CC1=CC=C(C=C1)F)C1=CC=C(C=C1)Cl GHBPXNGRPGLEEC-XFBWMNOSSA-N 0.000 claims description 2
• DMOPFPDBKUOWQW-DMTNHVFBSA-N (2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]morpholin-3-one Chemical compound ClC=1C=C(C=CC1)[C@H]1O[C@@H](C(N([C@H]1C1=CC=C(C=C1)Cl)CC1CC1)=O)CC(=O)N1CCN(CC1)C DMOPFPDBKUOWQW-DMTNHVFBSA-N 0.000 claims description 2
• LTDIAJLOLCVPIG-RAVGUYNFSA-N (2S,5R,6S)-4-[(2R)-1-aminopentan-2-yl]-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]morpholin-3-one Chemical compound CCC[C@H](CN)N1[C@@H]([C@@H](O[C@@H](Cc2ccc(F)cc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1 LTDIAJLOLCVPIG-RAVGUYNFSA-N 0.000 claims description 2
• XBDLXEHVSZYECN-ITGKQZKFSA-N (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2R)-1-(4-methylpiperazin-1-yl)-1-oxopentan-2-yl]morpholin-3-one Chemical compound CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2ccc(F)cc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(=O)N1CCN(C)CC1 XBDLXEHVSZYECN-ITGKQZKFSA-N 0.000 claims description 2
• XMOWLFHORUUXHL-ATIZSFMBSA-N (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2R)-1-morpholin-4-yl-1-oxopentan-2-yl]morpholin-3-one Chemical compound CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2ccc(F)cc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(=O)N1CCOCC1 XMOWLFHORUUXHL-ATIZSFMBSA-N 0.000 claims description 2
• GHBPXNGRPGLEEC-ITGKQZKFSA-N (2S,5R,6S)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2R)-1-morpholin-4-ylpentan-2-yl]morpholin-3-one Chemical compound CCC[C@H](CN1CCOCC1)N1[C@@H]([C@@H](O[C@@H](Cc2ccc(F)cc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1 GHBPXNGRPGLEEC-ITGKQZKFSA-N 0.000 claims description 2
• BWAAIHSLCUTHBS-RLXMVLCYSA-N (2r)-1-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]pyrrolidine-2-carboxylic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N1[C@H](CCC1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 BWAAIHSLCUTHBS-RLXMVLCYSA-N 0.000 claims description 2
• BWAAIHSLCUTHBS-NAGJOQLLSA-N (2r)-1-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]pyrrolidine-2-carboxylic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N1[C@H](CCC1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 BWAAIHSLCUTHBS-NAGJOQLLSA-N 0.000 claims description 2
• MRDGLMFSEFPRMJ-YTFSRNRJSA-N (2r)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]-2-(4-chlorophenyl)acetic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](C(=O)O)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 MRDGLMFSEFPRMJ-YTFSRNRJSA-N 0.000 claims description 2
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• UQASTWWEIVFSHY-KAGYGMCKSA-N (2r)-2-[(2r,3s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-2-methyl-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2N(C(CO[C@]2(C)C=2C=C(Cl)C=CC=2)=O)[C@H](CCC)C(O)=O)=CC=C(Cl)C=C1 UQASTWWEIVFSHY-KAGYGMCKSA-N 0.000 claims description 2
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• ZAWNFLSCDKKZCP-YZGWKJHDSA-N (2r)-2-[(2r,3s)-2-(4-chlorophenyl)-3-(3,4-dichlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=C(Cl)C(Cl)=CC=2)=CC=C(Cl)C=C1 ZAWNFLSCDKKZCP-YZGWKJHDSA-N 0.000 claims description 2
• IIIKIXKRUIFYHN-AKIFATBCSA-N (2r)-2-[(2r,3s)-2-(4-chlorophenyl)-3-(4-cyclopropylphenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(=CC=2)C2CC2)=CC=C(Cl)C=C1 IIIKIXKRUIFYHN-AKIFATBCSA-N 0.000 claims description 2
• BUGVQKZOFPGGOD-YZGWKJHDSA-N (2r)-2-[(2r,3s)-3-(4-bromophenyl)-2-(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Br)=CC=2)=CC=C(Cl)C=C1 BUGVQKZOFPGGOD-YZGWKJHDSA-N 0.000 claims description 2
• KSNIEWKPHUKWIK-YZGWKJHDSA-N (2r)-2-[(2r,3s)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1Cl KSNIEWKPHUKWIK-YZGWKJHDSA-N 0.000 claims description 2
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• NPPZSLNNEJILGK-JVYGEBFASA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(2-fluoro-4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1F NPPZSLNNEJILGK-JVYGEBFASA-N 0.000 claims description 2
• ROAXJFVTHGLTIQ-VJLHXPKFSA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-(3-chlorophenyl)acetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](C(=O)O)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 ROAXJFVTHGLTIQ-VJLHXPKFSA-N 0.000 claims description 2
• QYBDMSRKFASBLX-VJLHXPKFSA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-(4-chlorophenyl)acetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](C(=O)O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 QYBDMSRKFASBLX-VJLHXPKFSA-N 0.000 claims description 2
• TVTKMFRTMDPMSM-VJLHXPKFSA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-phenylacetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](C(=O)O)C=1C=CC=CC=1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 TVTKMFRTMDPMSM-VJLHXPKFSA-N 0.000 claims description 2
• MWHYTIMDFDUUCL-JVYGEBFASA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 MWHYTIMDFDUUCL-JVYGEBFASA-N 0.000 claims description 2
• FFYWGOJJTFJPLJ-FXSWLTOZSA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pent-4-enoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CC=C)C(=O)O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 FFYWGOJJTFJPLJ-FXSWLTOZSA-N 0.000 claims description 2
• BPTXICQAEGSTHS-FXSWLTOZSA-N (2r)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 BPTXICQAEGSTHS-FXSWLTOZSA-N 0.000 claims description 2
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• FIHSOWJVKMUORE-GCFVYEKYSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-5-oxo-6-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]morpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N1C=NC=N1 FIHSOWJVKMUORE-GCFVYEKYSA-N 0.000 claims description 2
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• AKQJJTYNRDWUSK-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-chlorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 AKQJJTYNRDWUSK-ZJSPYRCASA-N 0.000 claims description 2
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• MWHYTIMDFDUUCL-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]hexanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 MWHYTIMDFDUUCL-RAVGUYNFSA-N 0.000 claims description 2
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• JJOOVSOTAJEJLF-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-methoxyphenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(OC)C=C1 JJOOVSOTAJEJLF-RAVGUYNFSA-N 0.000 claims description 2
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• GYSDXBKUMJAGEH-ACESQOTJSA-N (2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[2-(dimethylamino)ethyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CCN(C)C)O2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 GYSDXBKUMJAGEH-ACESQOTJSA-N 0.000 claims description 2
• VWWCPRURKNDDAR-DMNJWKMDSA-N (2r)-2-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-[(4-fluorophenyl)methyl]pentanoic acid Chemical compound C([C@@](CCC)(N1C([C@H](CC=2C=CC(F)=CC=2)O[C@H]([C@H]1C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)=O)C(O)=O)C1=CC=C(F)C=C1 VWWCPRURKNDDAR-DMNJWKMDSA-N 0.000 claims description 2
• YYFBIAHAZGHHSV-QUMGSSFMSA-N (2r)-2-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]-2-cyclopropylacetic acid Chemical compound C1([C@H](C(=O)O)N2C([C@H](CC=3C=CC(F)=CC=3)O[C@H]([C@H]2C=2C=CC(Cl)=CC=2)C=2C=C(Cl)C=CC=2)=O)CC1 YYFBIAHAZGHHSV-QUMGSSFMSA-N 0.000 claims description 2
• LOBJSWXKCWZHRU-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C=CC=1)C1=CC=C(F)C=C1 LOBJSWXKCWZHRU-ZJSPYRCASA-N 0.000 claims description 2
• UVXJEGSLASNFDS-RAVGUYNFSA-N (2r)-2-[(2s,3r,6s)-2-(4-chloro-2-methylphenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C(=CC(Cl)=CC=1)C)C1=CC=C(F)C=C1 UVXJEGSLASNFDS-RAVGUYNFSA-N 0.000 claims description 2
• JGSDUUHREWFLDE-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-2-(4-chloro-3-fluorophenyl)-3-(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(F)C(Cl)=CC=1)C1=CC=C(F)C=C1 JGSDUUHREWFLDE-ZJSPYRCASA-N 0.000 claims description 2
• TVGRZWHDCBETPU-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C(=CC(Cl)=CC=1)Cl)C1=CC=C(F)C=C1 TVGRZWHDCBETPU-ZJSPYRCASA-N 0.000 claims description 2
• BZLYRIZTBQBHRB-ZJSPYRCASA-N (2r)-2-[(2s,3r,6s)-3-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=C(Cl)C(Cl)=CC=1)C1=CC=C(F)C=C1 BZLYRIZTBQBHRB-ZJSPYRCASA-N 0.000 claims description 2
• LWKLJVWPVADUAQ-JYRKZWEQSA-N (2r)-2-[(2s,5r,6s)-2-(2-amino-2-oxoethyl)-5,6-bis(4-chlorophenyl)-3-oxomorpholin-4-yl]pentanoic acid Chemical compound C1([C@H]2[C@H](N(C([C@H](CC(N)=O)O2)=O)[C@H](CCC)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 LWKLJVWPVADUAQ-JYRKZWEQSA-N 0.000 claims description 2
• SCIHNVZRVLKGMQ-ZJSPYRCASA-N (2r)-2-[(2s,5r,6s)-2-benzyl-5,6-bis(4-chlorophenyl)-3-oxomorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 SCIHNVZRVLKGMQ-ZJSPYRCASA-N 0.000 claims description 2
• RNOUYZSZHKHMEU-ZJSPYRCASA-N (2r)-2-[(2s,5r,6s)-5-(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-3-oxo-6-phenylmorpholin-4-yl]pentanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC=CC=1)C1=CC=C(F)C=C1 RNOUYZSZHKHMEU-ZJSPYRCASA-N 0.000 claims description 2
• CWAUKFZHSRAVQL-MGEHJEIGSA-N (2r)-2-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]propanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N[C@H](C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 CWAUKFZHSRAVQL-MGEHJEIGSA-N 0.000 claims description 2
• CWAUKFZHSRAVQL-AQPBRFSRSA-N (2r)-2-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]propanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N[C@H](C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 CWAUKFZHSRAVQL-AQPBRFSRSA-N 0.000 claims description 2
• HHCOGKKNQCRCGF-RQKPWJHBSA-N (2r)-2-amino-3-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]propanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NC[C@@H](N)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 HHCOGKKNQCRCGF-RQKPWJHBSA-N 0.000 claims description 2
• HHCOGKKNQCRCGF-FYYQJAJYSA-N (2r)-2-amino-3-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]propanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NC[C@@H](N)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 HHCOGKKNQCRCGF-FYYQJAJYSA-N 0.000 claims description 2
• NVRKHLCRIFHQOK-RUYTYSJGSA-N (2r)-3-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-methylpropanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NC[C@@H](C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 NVRKHLCRIFHQOK-RUYTYSJGSA-N 0.000 claims description 2
• NVRKHLCRIFHQOK-XYVGLUNFSA-N (2r)-3-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2-methylpropanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NC[C@@H](C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 NVRKHLCRIFHQOK-XYVGLUNFSA-N 0.000 claims description 2
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• LTDIAJLOLCVPIG-YYGZZXRFSA-N (2r,5s,6r)-4-[(2s)-1-aminopentan-2-yl]-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CN)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 LTDIAJLOLCVPIG-YYGZZXRFSA-N 0.000 claims description 2
• RHWGELPEQKFUHE-XPWALMASSA-N (2r,5s,6r)-5,6-bis(4-bromophenyl)-2-[(4-bromophenyl)methyl]-4-methylmorpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Br)=CC=1)C=1C=CC(Br)=CC=1)C1=CC=C(Br)C=C1 RHWGELPEQKFUHE-XPWALMASSA-N 0.000 claims description 2
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• FPKXWYRDEQIPKH-OZNIXHKMSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(2-fluoro-4-methylsulfonylphenyl)methyl]-4-pyridin-3-ylmorpholin-3-one Chemical compound FC1=CC(S(=O)(=O)C)=CC=C1C[C@@H]1C(=O)N(C=2C=NC=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 FPKXWYRDEQIPKH-OZNIXHKMSA-N 0.000 claims description 2
• IPJCFRDZXMOROQ-AKHDSKFASA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(2r)-2,3-dihydroxypropyl]-4-methylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](C[C@@H](O)CO)O2)=O)C)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 IPJCFRDZXMOROQ-AKHDSKFASA-N 0.000 claims description 2
• KAWBFOLKWOWQNK-ROXDYWFKSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(1s)-1-(2h-tetrazol-5-yl)butyl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C1=NNN=N1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 KAWBFOLKWOWQNK-ROXDYWFKSA-N 0.000 claims description 2
• OZZCSOBIPVVGCN-JVYGEBFASA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-fluorophenyl)methyl]-4-[(2r)-1-hydroxypentan-2-yl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CO)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 OZZCSOBIPVVGCN-JVYGEBFASA-N 0.000 claims description 2
• HCAYISRYXICNRK-ROXDYWFKSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[(4-iodophenyl)methyl]-4-[(1s)-1-(2h-tetrazol-5-yl)butyl]morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C1=NNN=N1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 HCAYISRYXICNRK-ROXDYWFKSA-N 0.000 claims description 2
• GTBIGGRMISCXCW-UODIDJSMSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-2-[[4-[(dimethylamino)methyl]phenyl]methyl]-4-methylmorpholin-3-one Chemical compound C1=CC(CN(C)C)=CC=C1C[C@@H]1C(=O)N(C)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 GTBIGGRMISCXCW-UODIDJSMSA-N 0.000 claims description 2
• KDMZQPXBRXKOKS-FXVJXKIMSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-(2-chloropyridin-4-yl)-2-[(4-fluorophenyl)methyl]morpholin-3-one Chemical compound C1=CC(F)=CC=C1C[C@@H]1C(=O)N(C=2C=C(Cl)N=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)[C@@H](C=2C=CC(Cl)=CC=2)O1 KDMZQPXBRXKOKS-FXVJXKIMSA-N 0.000 claims description 2
• LNNGRKMUIHMFPX-YUMYIRISSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(2r)-2,3-dihydroxypropyl]morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)C[C@@H](O)CO)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 LNNGRKMUIHMFPX-YUMYIRISSA-N 0.000 claims description 2
• LNNGRKMUIHMFPX-LNRXMEIDSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)-2-[(2s)-2,3-dihydroxypropyl]morpholin-3-one Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)C[C@H](O)CO)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 LNNGRKMUIHMFPX-LNRXMEIDSA-N 0.000 claims description 2
• FRJPQPIZOAFJPH-BPQIPLTHSA-N (2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-2-(2h-tetrazol-5-ylmethyl)morpholin-3-one Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C=1N=NNN=1 FRJPQPIZOAFJPH-BPQIPLTHSA-N 0.000 claims description 2
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• RZBOZYNANYNPDY-UXHICEINSA-N (5r,6s)-5,6-bis(4-chlorophenyl)-4-(cyclopropylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1[C@@H](C=2C=CC(Cl)=CC=2)N(CC2CC2)C(=O)CO1 RZBOZYNANYNPDY-UXHICEINSA-N 0.000 claims description 2
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• SPMXUJWZKOUETJ-MOPGFXCFSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-hydroxy-2-methylpropyl)morpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)CC(C)(O)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 SPMXUJWZKOUETJ-MOPGFXCFSA-N 0.000 claims description 2
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• YEADITPTMUCVLJ-UXHICEINSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-methylpropyl)morpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)CC(C)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 YEADITPTMUCVLJ-UXHICEINSA-N 0.000 claims description 2
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• SUKADUYCYVAULK-UXHICEINSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-1,1-dioxo-1,4-thiazinan-3-one Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CC2)C(=O)CS(=O)(=O)[C@H]1C1=CC=CC(Cl)=C1 SUKADUYCYVAULK-UXHICEINSA-N 0.000 claims description 2
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• ZUYDNBDMQAEZPD-SJORKVTESA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-methylmorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 ZUYDNBDMQAEZPD-SJORKVTESA-N 0.000 claims description 2
• VKUFOQXIICORFX-MOPGFXCFSA-N (5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-propan-2-ylthiomorpholin-3-one Chemical compound C1([C@H]2[C@H](N(C(CS2)=O)C(C)C)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 VKUFOQXIICORFX-MOPGFXCFSA-N 0.000 claims description 2
• HVSJWQOMQAUZJJ-HLAWJBBLSA-N (5s,6r)-4-[(2r)-1-aminopentan-2-yl]-5,6-bis(4-chlorophenyl)morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CN)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 HVSJWQOMQAUZJJ-HLAWJBBLSA-N 0.000 claims description 2
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• DALLVBVMPULHMF-PKTZIBPZSA-N (5s,6r)-4-benzyl-5,6-bis(4-bromophenyl)piperazin-2-one Chemical compound C1=CC(Br)=CC=C1[C@@H]1[C@H](C=2C=CC(Br)=CC=2)N(CC=2C=CC=CC=2)CC(=O)N1 DALLVBVMPULHMF-PKTZIBPZSA-N 0.000 claims description 2
• WAJRLDXLGCDAQX-ZWKOTPCHSA-N (5s,6r)-5,6-bis(4-bromophenyl)-4-ethylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)CC)C=2C=CC(Br)=CC=2)=CC=C(Br)C=C1 WAJRLDXLGCDAQX-ZWKOTPCHSA-N 0.000 claims description 2
• KWJNDERVFPWYAJ-RBUKOAKNSA-N (5s,6r)-5,6-bis(4-bromophenyl)-4-propan-2-ylmorpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)C(C)C)C=2C=CC(Br)=CC=2)=CC=C(Br)C=C1 KWJNDERVFPWYAJ-RBUKOAKNSA-N 0.000 claims description 2
• VTVJMRFHIGHVTQ-LEWJYISDSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-(2,6-dichloropyridin-4-yl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1[C@H](C=2C=CC(Cl)=CC=2)N(C=2C=C(Cl)N=C(Cl)C=2)C(=O)CO1 VTVJMRFHIGHVTQ-LEWJYISDSA-N 0.000 claims description 2
• IZCQHQAAXLBWGS-LEWJYISDSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-(2-chloropyridin-4-yl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1[C@H](C=2C=CC(Cl)=CC=2)N(C=2C=C(Cl)N=CC=2)C(=O)CO1 IZCQHQAAXLBWGS-LEWJYISDSA-N 0.000 claims description 2
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• QKPDERJMFUEBJZ-OEMFJLHTSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(1r)-1-(4-chlorophenyl)-2-hydroxyethyl]morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CO)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 QKPDERJMFUEBJZ-OEMFJLHTSA-N 0.000 claims description 2
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• QKPDERJMFUEBJZ-YFNKSVMNSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(1s)-1-(4-chlorophenyl)-2-hydroxyethyl]morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CO)C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 QKPDERJMFUEBJZ-YFNKSVMNSA-N 0.000 claims description 2
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• NPUKNXUSVLKLGA-SESVDKBCSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(2s)-1-hydroxypentan-2-yl]morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CO)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 NPUKNXUSVLKLGA-SESVDKBCSA-N 0.000 claims description 2
• NRDRYAOWCKDLIG-ZKMPZPQNSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-[(2s)-1-morpholin-4-ylpentan-2-yl]morpholin-3-one Chemical compound C([C@H](CCC)N1C(CO[C@@H]([C@@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)N1CCOCC1 NRDRYAOWCKDLIG-ZKMPZPQNSA-N 0.000 claims description 2
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• LTHTVCXIZFFMEH-LEWJYISDSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-pyridin-3-ylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1[C@H](C=2C=CC(Cl)=CC=2)N(C=2C=NC=CC=2)C(=O)CO1 LTHTVCXIZFFMEH-LEWJYISDSA-N 0.000 claims description 2
• NFUIRTFPUSSSBU-LEWJYISDSA-N (5s,6r)-5,6-bis(4-chlorophenyl)-4-pyridin-4-ylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1[C@H](C=2C=CC(Cl)=CC=2)N(C=2C=CN=CC=2)C(=O)CO1 NFUIRTFPUSSSBU-LEWJYISDSA-N 0.000 claims description 2
• UBQFROVZCWMDOT-SIKLNZKXSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2,2,6-trimethyl-1,1-dioxo-4-propan-2-yl-1,4-thiazinan-3-one Chemical compound C1([C@@H]2N(C(C(C)(C)S(=O)(=O)[C@@]2(C=2C=C(Cl)C=CC=2)C)=O)C(C)C)=CC=C(Cl)C=C1 UBQFROVZCWMDOT-SIKLNZKXSA-N 0.000 claims description 2
• FGWXAEQUAWMQJO-VQTJNVASSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(1,3-thiazol-4-ylmethyl)morpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(CC=2N=CSC=2)C(=O)CO[C@@H]1C1=CC=CC(Cl)=C1 FGWXAEQUAWMQJO-VQTJNVASSA-N 0.000 claims description 2
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• JGNOFMCABZIOJJ-RBUKOAKNSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(2-methoxyethyl)morpholin-3-one Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)CCOC)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 JGNOFMCABZIOJJ-RBUKOAKNSA-N 0.000 claims description 2
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• YUCPGGRZBHWSOS-RBUKOAKNSA-N (5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-cyclopropylsulfonylmorpholin-3-one Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(S(=O)(=O)C2CC2)C(=O)CO[C@@H]1C1=CC=CC(Cl)=C1 YUCPGGRZBHWSOS-RBUKOAKNSA-N 0.000 claims description 2
• IAXQDFUNSAJUPQ-GPXOXTDOSA-N 1-[(2R)-2-[(2S,3R)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperidine-4-carboxylic acid Chemical compound ClC1=CC=C(C=C1)[C@H]1[C@H](N(C(CO1)=O)[C@@H](C(=O)N1CCC(CC1)C(=O)O)CCC)C1=CC=C(C=C1)Cl IAXQDFUNSAJUPQ-GPXOXTDOSA-N 0.000 claims description 2
• ODHVFUZLPHKYAU-ATIZSFMBSA-N 1-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]azetidine-3-carboxylic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N1CC(C1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ODHVFUZLPHKYAU-ATIZSFMBSA-N 0.000 claims description 2
• CAAWFBFPQTYVGS-AIQXTLEGSA-N 1-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]azetidine-3-carboxylic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N1CC(C1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 CAAWFBFPQTYVGS-AIQXTLEGSA-N 0.000 claims description 2
• DCKDPLFEFIVNLL-IQLXHWPESA-N 1-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentyl]piperidine-4-carboxylic acid Chemical compound C([C@@H](CCC)N1C([C@H](CC=2C=CC(F)=CC=2)O[C@H]([C@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)N1CCC(C(O)=O)CC1 DCKDPLFEFIVNLL-IQLXHWPESA-N 0.000 claims description 2
• NANBAGSGGMNGDK-ITGKQZKFSA-N 1-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]piperidine-4-carboxylic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N1CCC(CC1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 NANBAGSGGMNGDK-ITGKQZKFSA-N 0.000 claims description 2
• IAXQDFUNSAJUPQ-ZKMPZPQNSA-N 1-[(2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperidine-4-carboxylic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(=O)N2CCC(CC2)C(O)=O)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 IAXQDFUNSAJUPQ-ZKMPZPQNSA-N 0.000 claims description 2
• ODHVFUZLPHKYAU-RRGQHJHPSA-N 1-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]azetidine-3-carboxylic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N1CC(C1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ODHVFUZLPHKYAU-RRGQHJHPSA-N 0.000 claims description 2
• CAAWFBFPQTYVGS-ICYKMPLBSA-N 1-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]azetidine-3-carboxylic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N1CC(C1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 CAAWFBFPQTYVGS-ICYKMPLBSA-N 0.000 claims description 2
• DCKDPLFEFIVNLL-MLMSKLGMSA-N 1-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentyl]piperidine-4-carboxylic acid Chemical compound C([C@H](CCC)N1C([C@@H](CC=2C=CC(F)=CC=2)O[C@@H]([C@@H]1C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)=O)N1CCC(C(O)=O)CC1 DCKDPLFEFIVNLL-MLMSKLGMSA-N 0.000 claims description 2
• NANBAGSGGMNGDK-XFBWMNOSSA-N 1-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N1CCC(CC1)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 NANBAGSGGMNGDK-XFBWMNOSSA-N 0.000 claims description 2
• AXLFRXXLVUJAFX-RMVXJAJNSA-N 2-[(2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxo-4-[(1R)-1-(2H-tetrazol-5-yl)butyl]morpholin-2-yl]acetic acid Chemical compound N1N=NN=C1[C@@H](CCC)N1C([C@H](O[C@@H]([C@@H]1C1=CC=C(C=C1)Cl)C1=CC(=CC=C1)Cl)CC(=O)O)=O AXLFRXXLVUJAFX-RMVXJAJNSA-N 0.000 claims description 2
• AXLFRXXLVUJAFX-MMKMLUHNSA-N 2-[(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxo-4-[(1S)-1-(2H-tetrazol-5-yl)butyl]morpholin-2-yl]acetic acid Chemical compound N1N=NN=C1[C@H](CCC)N1C([C@@H](O[C@H]([C@H]1C1=CC=C(C=C1)Cl)C1=CC(=CC=C1)Cl)CC(=O)O)=O AXLFRXXLVUJAFX-MMKMLUHNSA-N 0.000 claims description 2
• QDILNQYTSNQECW-RMVXJAJNSA-N 2-[(2r,5s,6r)-4-[(2r)-1-amino-1-oxopentan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid Chemical compound C1([C@@H]2[C@@H](N(C([C@@H](CC(O)=O)O2)=O)[C@H](CCC)C(N)=O)C=2C=CC(Cl)=CC=2)=CC=CC(Cl)=C1 QDILNQYTSNQECW-RMVXJAJNSA-N 0.000 claims description 2
• FTMBFKSFLLFQNY-AKIFATBCSA-N 2-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]-n,n-dimethylacetamide Chemical compound N1([C@H]([C@H](O[C@@H](C1=O)CC(=O)N(C)C)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 FTMBFKSFLLFQNY-AKIFATBCSA-N 0.000 claims description 2
• FTMBFKSFLLFQNY-WWNPGLIZSA-N 2-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]-n,n-dimethylacetamide Chemical compound N1([C@@H]([C@@H](O[C@H](C1=O)CC(=O)N(C)C)C=1C=C(Cl)C=CC=1)C=1C=CC(Cl)=CC=1)CC1CC1 FTMBFKSFLLFQNY-WWNPGLIZSA-N 0.000 claims description 2
• VQBIJVGCPBDOQG-RCXJIHSJSA-N 2-[4-[(2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]acetic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(=O)N2CCN(CC(O)=O)CC2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 VQBIJVGCPBDOQG-RCXJIHSJSA-N 0.000 claims description 2
• IJRDKLRHAXUUKI-IZSFFQSRSA-N 2-[4-[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]acetic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N1CCN(CC(O)=O)CC1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 IJRDKLRHAXUUKI-IZSFFQSRSA-N 0.000 claims description 2
• VQBIJVGCPBDOQG-UCGXPXSYSA-N 2-[4-[(2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]acetic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(=O)N2CCN(CC(O)=O)CC2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 VQBIJVGCPBDOQG-UCGXPXSYSA-N 0.000 claims description 2
• IJRDKLRHAXUUKI-NTQAFHMMSA-N 2-[4-[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]acetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N1CCN(CC(O)=O)CC1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 IJRDKLRHAXUUKI-NTQAFHMMSA-N 0.000 claims description 2
• NJPCNMAIFNVBLQ-GEEWNISJSA-N 2-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]-methylamino]acetic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)N(C)CC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 NJPCNMAIFNVBLQ-GEEWNISJSA-N 0.000 claims description 2
• MMWOGKGDLMPDNR-TZRRMPRUSA-N 2-[[(2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzonitrile Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1C#N MMWOGKGDLMPDNR-TZRRMPRUSA-N 0.000 claims description 2
• NJPCNMAIFNVBLQ-IXGYBEARSA-N 2-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-fluorophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]-methylamino]acetic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)N(C)CC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(F)C=C1 NJPCNMAIFNVBLQ-IXGYBEARSA-N 0.000 claims description 2
• MMWOGKGDLMPDNR-VXNXHJTFSA-N 2-[[(2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzonitrile Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1C#N MMWOGKGDLMPDNR-VXNXHJTFSA-N 0.000 claims description 2
• XABBNPPXNJCCLT-LEWJYISDSA-N 3-[(2r,3s)-3-(4-chlorophenyl)-4-(cyclopropylmethyl)-5-oxomorpholin-2-yl]benzonitrile Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(CC2CC2)C(=O)CO[C@@H]1C1=CC=CC(C#N)=C1 XABBNPPXNJCCLT-LEWJYISDSA-N 0.000 claims description 2
• IYPPDCFULNNMSW-BHIFYINESA-N 3-[(2r,5s,6r)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]propanenitrile Chemical compound C1=CC(Cl)=CC=C1[C@@H]1N(CC2CC2)C(=O)[C@@H](CCC#N)O[C@@H]1C1=CC=CC(Cl)=C1 IYPPDCFULNNMSW-BHIFYINESA-N 0.000 claims description 2
• XABBNPPXNJCCLT-RTWAWAEBSA-N 3-[(2s,3r)-3-(4-chlorophenyl)-4-(cyclopropylmethyl)-5-oxomorpholin-2-yl]benzonitrile Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CC2)C(=O)CO[C@H]1C1=CC=CC(C#N)=C1 XABBNPPXNJCCLT-RTWAWAEBSA-N 0.000 claims description 2
• IYPPDCFULNNMSW-BDTNDASRSA-N 3-[(2s,5r,6s)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl]propanenitrile Chemical compound C1=CC(Cl)=CC=C1[C@H]1N(CC2CC2)C(=O)[C@H](CCC#N)O[C@H]1C1=CC=CC(Cl)=C1 IYPPDCFULNNMSW-BDTNDASRSA-N 0.000 claims description 2
• DLHUKVSGVNYFLF-MVNQZMKCSA-N 3-[4-[(2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]propanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@H](CCC)C(=O)N2CCN(CCC(O)=O)CC2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 DLHUKVSGVNYFLF-MVNQZMKCSA-N 0.000 claims description 2
• DLHUKVSGVNYFLF-MSLLRLGPSA-N 3-[4-[(2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentanoyl]piperazin-1-yl]propanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@@H](CCC)C(=O)N2CCN(CCC(O)=O)CC2)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 DLHUKVSGVNYFLF-MSLLRLGPSA-N 0.000 claims description 2
• BTJPJTMEFRMSFV-FOVJLYNBSA-N 3-[[(2r)-2-[(2s,3r)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentyl]amino]-3-oxopropanoic acid Chemical compound C1([C@H]2[C@H](N(C(CO2)=O)[C@@H](CNC(=O)CC(O)=O)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 BTJPJTMEFRMSFV-FOVJLYNBSA-N 0.000 claims description 2
• ZDMBTZRSVDIRDM-ATIZSFMBSA-N 3-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2,2-dimethylpropanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NCC(C)(C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ZDMBTZRSVDIRDM-ATIZSFMBSA-N 0.000 claims description 2
• HCLAPAZXKFMQQR-ZIMFAVFZSA-N 3-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentyl]amino]-3-oxopropanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@@H](CNC(=O)CC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 HCLAPAZXKFMQQR-ZIMFAVFZSA-N 0.000 claims description 2
• GFOZQYQHUOXZGF-XPWALMASSA-N 3-[[(2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(C(O)=O)=C1 GFOZQYQHUOXZGF-XPWALMASSA-N 0.000 claims description 2
• RVNLWHXLSQTBHF-TZRRMPRUSA-N 3-[[(2r,5s,6r)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzonitrile Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(C#N)=C1 RVNLWHXLSQTBHF-TZRRMPRUSA-N 0.000 claims description 2
• BTJPJTMEFRMSFV-WDJPJFJCSA-N 3-[[(2s)-2-[(2r,3s)-2,3-bis(4-chlorophenyl)-5-oxomorpholin-4-yl]pentyl]amino]-3-oxopropanoic acid Chemical compound C1([C@@H]2[C@@H](N(C(CO2)=O)[C@H](CNC(=O)CC(O)=O)CCC)C=2C=CC(Cl)=CC=2)=CC=C(Cl)C=C1 BTJPJTMEFRMSFV-WDJPJFJCSA-N 0.000 claims description 2
• ZDMBTZRSVDIRDM-RRGQHJHPSA-N 3-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-cyanophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]-2,2-dimethylpropanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C(=O)NCC(C)(C)C(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ZDMBTZRSVDIRDM-RRGQHJHPSA-N 0.000 claims description 2
• HCLAPAZXKFMQQR-FKPPXMAGSA-N 3-[[(2s)-2-[(2r,3s,6r)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentyl]amino]-3-oxopropanoic acid Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@H](CNC(=O)CC(O)=O)CCC)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 HCLAPAZXKFMQQR-FKPPXMAGSA-N 0.000 claims description 2
• GFOZQYQHUOXZGF-ZRBLBEILSA-N 3-[[(2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(C(O)=O)=C1 GFOZQYQHUOXZGF-ZRBLBEILSA-N 0.000 claims description 2
• RVNLWHXLSQTBHF-VXNXHJTFSA-N 3-[[(2s,5r,6s)-5,6-bis(4-chlorophenyl)-4-methyl-3-oxomorpholin-2-yl]methyl]benzonitrile Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)C)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=CC(C#N)=C1 RVNLWHXLSQTBHF-VXNXHJTFSA-N 0.000 claims description 2
• ATFUGFUUNIXVJV-RAVGUYNFSA-N 4-[[(2S,5R,6S)-5,6-bis(4-chlorophenyl)-3-oxo-4-[(1R)-1-(2H-tetrazol-5-yl)butyl]morpholin-2-yl]methyl]benzonitrile Chemical compound CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2ccc(cc2)C#N)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1nnn[nH]1 ATFUGFUUNIXVJV-RAVGUYNFSA-N 0.000 claims description 2
• YUHWFYBTXQQXNJ-JJILFORISA-N 4-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-iodophenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]butanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NCCCC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(I)C=C1 YUHWFYBTXQQXNJ-JJILFORISA-N 0.000 claims description 2
• ILWAHSOWRYCOHU-HUAAZGBFSA-N 4-[[(2r)-2-[(2s,3r,6s)-2,3-bis(4-chlorophenyl)-6-[(4-methylsulfonylphenyl)methyl]-5-oxomorpholin-4-yl]pentanoyl]amino]butanoic acid Chemical compound C([C@@H]1O[C@H]([C@H](N(C1=O)[C@H](CCC)C(=O)NCCCC(O)=O)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(S(C)(=O)=O)C=C1 ILWAHSOWRYCOHU-HUAAZGBFSA-N 0.000 claims description 2
• ATFUGFUUNIXVJV-YYGZZXRFSA-N 4-[[(2r,5s,6r)-5,6-bis(4-chlorophenyl)-3-oxo-4-[(1s)-1-(2h-tetrazol-5-yl)butyl]morpholin-2-yl]methyl]benzonitrile Chemical compound C([C@H]1O[C@@H]([C@@H](N(C1=O)[C@@H](CCC)C1=NNN=N1)C=1C=CC(Cl)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(C#N)C=C1 ATFUGFUUNIXVJV-YYGZZXRFSA-N 0.000 claims description 2
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