JP6408354B2 - Inspection device and production management method - Google Patents

Description

  The present invention relates to an inspection apparatus for inspecting foreign matter and residues adhering to a container, and a production management method for managing a production line for producing various kinds of medicines or foods (including health foods) using the inspection apparatus. About.

  As a method for inspecting foreign matter and residues attached to the container, Patent Document 1 discloses that the illumination lamp and the camera are inserted into the drum can, the interior of the drum can be illuminated with the illumination lamp, and the inside of the drum can be photographed with the camera. A method for inspecting foreign matter or the like adhering to the inside of a drum can by using the photographed image is disclosed.

Japanese Patent Laid-Open No. 9-288067

  However, when the inside of the container is illuminated with an illuminating lamp and the inside of the container is photographed with a camera, the illuminating lamp is subjected to multiple reflections from the inner surface of the container, and these become strong noises. Is difficult to detect from a photographed image photographed by a camera.

  The main object of the present invention is to provide an inspection apparatus capable of detecting foreign matter and residue deposits without being affected by multiple reflections even with minute foreign matter or residues attached to the container. Another object of the present invention is to provide an inspection apparatus capable of quantitatively detecting the amount of adhesion of residues.

  Another object of the present invention is to produce a trace amount of residue adhering to the inner surface of a cleaned container in a production line that manufactures a wide variety of drugs or foods (including health foods) by sharing the same container. Another object of the present invention is to provide a production management method capable of detecting without being affected by multiple reflections, and further a production management method capable of determining the quality of cleaning based on the detection result of the residue.

  An inspection apparatus according to the present invention is an inspection apparatus for inspecting foreign matter adhering to an inner surface of an object having an inner space, and a light source for irradiating excitation light toward the inner surface of the object and light emission from the foreign matter by irradiation of excitation light. An imaging unit that captures a fluorescent image of the fluorescent light, and a detection unit that detects foreign matter adhering to the inner surface of the object from the fluorescent image captured by the imaging unit, wherein at least the inner surface of the object is fluorescent by excitation light irradiation. The foreign material includes a material that emits fluorescence when irradiated with excitation light.

  Another inspection apparatus according to the present invention is an inspection apparatus that inspects an object to be inspected on the inner surface of an object having an inner space, and is inspected by irradiating light energy toward the inner surface of the object, and irradiation with light energy A detection unit that detects the emission energy that has been converted and released by the object, and an inspection unit that inspects the state of the inspection object based on the emission position of the emission energy detected by the detection unit and the emission energy. It is characterized by having.

  The production management method according to the present invention is a production management method for a production line that manufactures various types of chemicals by sharing the same container, and manufactures the next lot of chemicals after the production of the previous lot of chemicals is completed. Before, the process (A) which wash | cleans a container, and the process (B) which test | inspects the residue of the chemical | medical agent of the previous lot adhering to the inner surface of a container after a process (A) are included. The step (B) includes a step (B1) of irradiating the inner surface of the container with excitation light, a step (B2) of photographing a fluorescent image of fluorescence emitted from the residue by the irradiation of the excitation light, and the photographed fluorescence. From the image, the position of the residue adhered to the inner surface of the container, the adhesion area of the residue adhered to the inner surface of the container, and the step (B3) of measuring the fluorescence brightness of the fluorescence emitted from the residue were measured. Based on the relationship information indicating the relationship between the mass per unit area of the residue determined in advance and the fluorescence intensity of the fluorescence emitted from the residue, the amount of residue at the specific attachment position is determined. And at least the inner surface of the container is made of a material that does not emit fluorescence when irradiated with excitation light.

  ADVANTAGE OF THE INVENTION According to this invention, the inspection apparatus which can detect the deposit | attachment of a foreign material and a residue, even if it is the minute foreign material and the residue adhering in the container, without being influenced by multiple reflection can be provided.

It is the figure which showed typically the structure of the test | inspection apparatus in one Embodiment of this invention. It is the graph which showed the relationship between the mass per unit area of the material which light-emits fluorescence, and the fluorescence brightness | luminance of light-emission fluorescence. (A)-(d) is the figure which showed the method of calculating | requiring the relationship between the mass per unit area, and fluorescence luminance. It is the flowchart which showed the process of the production management method in other embodiment of this invention. It is the figure which showed the method of imaging | photography by dividing | segmenting a test object area | region.

  Before explaining the present invention, the background of the inventors of the present invention will be explained.

  In the field of medicines or foods (including health foods), there are many processes in the production process from drug substances to intermediates to final products. In addition, in order to deal with a variety of small-quantity production, a production line is set up for manufacturing a variety of chemicals by sharing the same container and introducing chemicals or foods into the container.

  In such a production line, when the production of one product is finished, the used container is washed, but if a small amount of residue remains in the container, the residue will be included in the next product process. May affect the quality of the next product. In particular, the management regulations for chemicals are strict, and for example, the amount of residue in a container after cleaning is defined to be 10 ppm or less with respect to 100 kg of the amount of powder charged into the container. Sometimes it is.

  The residue defined in this way is a minute amount corresponding to a film thickness of about several tens of μm, for example, in terms of the film thickness of the residue adhered to the entire surface of the container.

  Conventionally, such a trace amount of residue has been inspected by an experienced person who is experienced and inspected based on intuition. However, such an inspection is not a quantitative inspection and varies from person to person. In addition, since it is necessary to visually check the inside of the container, there is a possibility that foreign substances derived from living bodies such as hair may be mixed in the container.

  On the other hand, wipe the inside of the container after washing with paper or absorbent cotton, etc., and use the mass spectrometer to analyze the residue adhering to the so-called sampling inspection. There is.

  However, in the sampling inspection, since the position of the residue adhered in the container varies, the measured value varies depending on the location to be wiped off. Therefore, even if the total amount of the residue adhered in the container is estimated, the accuracy is very poor. . In addition, this method requires time for measurement and greatly reduces the production efficiency.

  The inventors of the present application have examined an inspection method capable of quantitatively detecting the amount of adhesion of foreign matter even with a minute foreign matter or residue (hereinafter simply referred to as “foreign matter”) adhering to the container. The following knowledge was obtained.

  That is, if the wavelength of the light radiated toward the inner surface of the container and the wavelength of the light radiated by the reaction of the foreign substance change due to the irradiation of the light, By detecting light having a wavelength that does not include the wavelength component of light, it is possible to detect minute foreign matters without being affected by the multiple reflection of the irradiated light.

  The inventors of the present application indicate that the component constituting a drug or food (including health food) contains a large amount of organic matter, and the organic matter has a characteristic of emitting visible light fluorescence when irradiated with ultraviolet light. Focused on. In other words, when the foreign matter attached to the container is made of a material that emits fluorescence, such as organic matter, the inner surface of the container is irradiated with excitation light such as ultraviolet rays, and the foreign matter is emitted by irradiation with the excitation light. By detecting the fluorescent light such as visible light, it is possible to detect minute foreign matters attached to the container without being affected by the multiple reflection of the excitation light. However, if the container itself is made of a material that emits fluorescence when irradiated with excitation light, the amount of fluorescence emitted by the container is much larger than the amount of fluorescence emitted by the foreign object, so detection of minute foreign objects Becomes difficult. Accordingly, the container is preferably made of a material that does not emit fluorescence when irradiated with excitation light.

  However, although it is possible to detect the presence of the foreign matter satisfactorily by such means, it is not possible to quantitatively examine the foreign matter attached to the container. Therefore, as a result of various studies, the inventors of the present application have found that there is a certain correlation between the concentration of foreign matter attached to the container (mass per unit area) and the fluorescence intensity of the fluorescence emitted by the foreign matter. I found. That is, if the adhesion area and the fluorescence brightness of the foreign matter attached to the container can be measured from the fluorescence image obtained by photographing the fluorescence emitted from the foreign matter, the mass of the foreign matter attached to the container can be determined by the concentration of the foreign matter (per unit area). It is possible to calculate uniquely using the correlation between (mass) and fluorescence luminance.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. In addition, this invention is not limited to the following embodiment. Moreover, it can change suitably in the range which does not deviate from the range which has the effect of this invention.

  FIG. 1 is a diagram schematically showing the configuration of an inspection apparatus according to an embodiment of the present invention.

  As shown in FIG. 1, the inspection apparatus 1 according to the present embodiment is an inspection apparatus that inspects foreign matters attached to the inner surface of an object 20 having an inner space. Here, “an object having an inner space” means an object having at least an inner surface arranged opposite to each other and / or an inner surface arranged adjacent to each other, and an inner space formed inside the inner surface. An object having an inner space that undergoes multiple reflections. The “object having the inner space” includes a pipe, a groove (channel), a chevron (angle), etc., in addition to a container having a bottomed box or a cylindrical body. In the following description, “an object having an inner space” is simply referred to as a “container”.

  As shown in FIG. 1, an inspection apparatus 1 includes a light source 11 that irradiates excitation light toward the inner surface of a container 20, an imaging unit 10 that captures a fluorescent image of fluorescence emitted from a foreign object by irradiation of excitation light, and an imaging And a detection unit 13 that detects foreign matter adhering to the inner surface of the container 20 from a fluorescent image photographed by the unit 10.

The light source 11 and the imaging unit 10 are respectively disposed in the inner space of the container 20, and the excitation light emitted from the light source 11 irradiates the region R ₁ of the inner surface 20 </ b> A of the container 20. From foreign matter X ₁ attached to the inner surface 20A of the region R _1, the fluorescence emitted by irradiation with the excitation light is incident on the imaging unit 10, the fluorescence image of the fluorescence emitted by the foreign matter X ₁ is taken.

  In the present embodiment, at least the inner surface of the container 20 is made of a material that does not emit fluorescence when irradiated with excitation light. For example, when the container 20 is comprised with the metal, or the container 20 is comprised with resin, the thing by which the metal layer is formed in the inner surface is included.

Further, the foreign matter X ₁ attached to the inner surface of the container 20 comprises a material that emits fluorescence by irradiation of the excitation light. For example, the foreign matter X ₁ include those containing organic substances, or those which fluorescence other than organics (e.g., a portion or a semiconductor material, such as some minerals).

  The detection unit 13 detects, from the fluorescent image captured by the imaging unit 10, the attachment position of the foreign matter attached to the inner surface of the container 20, the attachment area S of the foreign matter attached to the inner surface of the container 20, and the fluorescence brightness Q of the fluorescence emitted by the foreign matter. It has a function to measure each.

  Further, the inspection apparatus 1 includes a storage unit 15 and a calculation unit 14. The storage unit 15 stores relationship information obtained in advance for the relationship between the mass per unit area (M / S) of the foreign matter and the fluorescence luminance Q of the fluorescence emitted by the foreign matter. Further, in the calculation unit 14, the mass of the foreign matter at the specific attachment position measured by the detection unit 13 is based on the relationship information stored in the storage unit 15, and the adhesion area S of the foreign matter measured by the detection unit 13 and Calculated from the fluorescence luminance Q.

  FIG. 2 is a graph showing the relationship between the mass per unit area (M / S) of a material that emits fluorescence and the fluorescence luminance Q of the fluorescence emitted from the material. The curves indicated by A, B, and C in the figure indicate the relationship between the mass per unit area (M / S) and the fluorescence luminance Q obtained for different materials, respectively.

  FIGS. 3A to 3D are diagrams showing an example of a method for obtaining the relationship between the mass per unit area (M / S) and the fluorescence luminance Q. FIG.

  As shown in FIGS. 3A to 3D, a sample 30 of the material to be measured is attached to the inner surface 20A of the container 20 shown in FIG. 1, and the attached sample 30 is irradiated with ultraviolet rays. The fluorescence brightness Q of the emitted fluorescence and the area S of the sample are measured. Then, the amount (mass M) of the sample 30 attached to the inner surface 20A of the container 20 is changed, and the fluorescence luminance Q and the area S of the sample 30 in each amount are measured. The mass (M / S) per unit area of the sample 30 is obtained by dividing the mass M of the sample attached to the inner surface 20A of the container 20 by the 30 area S of the sample.

  As shown in FIGS. 3A to 3C, as the amount (mass M) of the sample 30 put into the measurement container 20 is increased, the fluorescence luminance Q in the sample 30 also increases, and as a primary approximation, As shown in FIG. 2, the mass per unit area (M / S) and the fluorescence luminance Q have a substantially linear relationship.

  Note that the relationship between the mass per unit area (M / S) and the fluorescence luminance Q shown in FIG. 2 is an example, and may have a non-linear relationship.

  Therefore, as shown in FIG. 2, if a region where the relationship between the mass per unit area (M / S) and the fluorescence luminance Q has a substantially linear relationship is used, the fluorescence luminance Q of the foreign matter measured by the detection unit 13 is used. Thus, the mass per unit area (M / S) of the foreign matter can be uniquely determined. Then, the mass M of the foreign matter attached to the container 20 can be obtained quantitatively by multiplying the obtained mass per unit area (M / S) by the adhesion area S of the foreign matter measured by the detection unit 13. it can.

  Further, as shown in FIG. 2, the relationship between the mass per unit area (M / S) and the fluorescence luminance Q is different for each material. Therefore, the storage unit 15 stores the relationship between the mass per unit area (Mi / S) of each foreign material Xi and the fluorescence brightness Qi of the fluorescence emitted by the foreign material Xi for each foreign material Xi of different materials. The relationship information obtained in advance is stored. As a result, the calculation unit 14 can calculate the mass Mi of the specific foreign object Xi using the relationship information with respect to the specific foreign object Xi stored in the storage unit 15.

  According to the inspection apparatus in the present embodiment, it is possible to detect with high sensitivity even a minute foreign matter or a residue attached in a container by photographing a fluorescent image of fluorescence emitted by the foreign matter by irradiation of excitation light. Further, based on the relationship between the mass per unit area of the foreign matter (M / S) obtained in advance and the fluorescence luminance Q of the fluorescence emitted by the foreign matter, the mass of the minute foreign matter and residue adhered in the container, It can be calculated quantitatively.

(Other embodiments of the present invention)
As described above, the inspection apparatus according to the present invention can quantitatively detect the adhesion amount of foreign matter and residue even with minute foreign matter and residue attached in the container. Therefore, in the production line that uses this detection device to manufacture a wide variety of medicines or foods (including health foods) by sharing the same container, a small amount of residue adhered to the inner surface of the cleaned container Can be detected quantitatively. Thereby, the quality of washing | cleaning can be determined by comparing the detected adhesion amount (mass) of the residue with the preset reference value.

  FIG. 4 is a flowchart showing the steps of a production management method according to another embodiment of the present invention.

  The production management method in the present embodiment is applied to a production line that manufactures various types of medicines or foods (hereinafter simply referred to as “medicine etc.”) by sharing the same container, and as shown in FIG. After the manufacture of the chemicals (step S1), before manufacturing the next lot of chemicals, etc., the process of washing the containers (step S2), and then the remaining of the previous lot of chemicals, etc. adhering to the inner surface of the container And a step of inspecting an object (step S3).

  The step of inspecting the residue can be performed using the inspection apparatus 1 in the present embodiment. Hereinafter, the residue inspection process will be described with reference to FIG. 1 again. In the following description, the container 20 in the figure is a container used in a production line for producing chemicals and the like. Moreover, the foreign material adhering to the container 20 is a residue remaining in the container 20 after cleaning. At least the inner surface of the container 20 is made of a material that does not emit fluorescence when irradiated with excitation light.

  Excitation light is emitted from the light source 11 toward the inner surface of the container 20, and a fluorescence fluorescence image emitted from the residue by the excitation light irradiation is captured by the imaging unit 10. Next, from the fluorescent image photographed by the imaging unit 10, the attachment position of the residue attached to the inner surface of the container 20, the adhesion area S of the residue attached to the inner surface of the container 20, and the fluorescence brightness of the fluorescence emitted from the residue Each Q is measured. The relationship between the mass (M / S) of the residue per unit area determined in advance and the fluorescence luminance Q of the fluorescence emitted from the residue is shown for the mass M of the residue at the specific adhesion position measured. Based on the relationship information, the adhesion area S of the residue and the fluorescence luminance Q are calculated.

  In addition, when the residue has adhered in the container 20 at a plurality of positions, the total amount of the residue adhered in the container 20 is the sum of the masses of the residues at the respective adhesion positions of the entire container 20. Calculated.

  After the quantitative inspection of the residue, as shown in FIG. 4, the total mass of the residue is compared with a preset reference value to determine whether the cleaning is good or bad (step S4). If the sum of the masses of the residues is larger than a preset reference value, the cleaning process (step S2) of the container 20 is performed again as a cleaning failure. If the sum of the masses of the residues is smaller than a preset reference value, the production of the next lot of chemicals and the like is started (step S5).

  According to the production management method in the present embodiment, after manufacturing the chemicals of the previous lot, before manufacturing the chemicals of the next lot, after cleaning the containers used for manufacturing the chemicals of the previous lot, Since the total amount of the residue remaining on the surface can be detected quantitatively, it is possible to accurately determine the quality of the container cleaning process. Thereby, it can prevent that the material used with the chemical | medical agent of the previous lot etc. mixes in the manufacturing process of the chemical | medical agent of the next lot, etc., and production management of the chemical | medical agent etc. excellent in quality can be performed.

  In addition, the production management method according to the present embodiment is not limited to the determination that the total amount of residue remaining in the container is compared with a predetermined reference value. For example, the concentration or adhesion area of one residue It is also possible to apply a determination that compares the value with a predetermined reference value.

  Moreover, in this embodiment, since the adhesion position of the residue adhering to the inner surface of the container can also be detected, the position where the adhesion frequency of the residue is high can be extracted from the inspection data in the cleaning process. Thereby, it can be set as the index which improves the washing machine used for a washing process.

  In addition, if the adhesion position and amount of residue differ depending on the type of chemical, etc., such characteristics can be extracted from the inspection data, so an indicator that changes the cleaning conditions of the washing machine depending on the type of chemical, etc. Can be.

In addition, by accumulating the types of chemicals manufactured on the production line, lot numbers, used container numbers, cleaning conditions, etc., and the inspection results of residues, stable quality control and Analysis can be performed when defects occur.
[Specific configuration of inspection device]
Again, an example of a specific configuration of the inspection apparatus of the present invention will be described with reference to FIG.

As shown in FIG. 1, the inspection apparatus 1 includes a light source 11, an imaging unit 10, and a detection unit 13. The light source 11 irradiates ultraviolet light (excitation light) toward the inspection target region R ₁ set on the inner surface 20 </ b> A of the container 20. The light source 11 may be an LED or laser that irradiates ultraviolet light, or a mercury lamp or halogen illumination that emits light of an ultraviolet light component. The light source 11 includes a filter (not shown) that allows ultraviolet light to pass through. Here, the filter attenuates the fluorescence component light received by the imaging unit 10 while efficiently transmitting the light having the wavelength of the excitation component.

  For example, when the foreign substance X to be detected emits fluorescence in the range of 500 to 600 nm when irradiated with excitation light of 300 to 400 nm, a UV-LED having a peak wavelength of 300 to 400 nm is used as the light source 11. . As the filter, a so-called band-pass filter that passes light having a wavelength of 300 to 400 nm and attenuates light having a wavelength in other bands is used. Alternatively, a so-called short-pass filter that transmits a wavelength of 450 nm or less and attenuates light having a wavelength of 450 nm or more may be used. By doing so, it is possible to cut light of an unnecessary wavelength that hinders photographing in the imaging unit 10 described later.

Imaging unit 10 is for capturing the inspection area R _1. The imaging unit 10 acquires, as a two-dimensional image, a fluorescence emission component that emits light from the foreign object X that is the inspection target. For example, the imaging unit 10 can use an imaging camera including an imaging device that includes, in the light receiving sensitivity, the wavelength of light of a fluorescent light emitting component that emits light from a foreign object that is an inspection target. Imaging unit 10 includes a lens and a filter, not shown, and are disposed against the inspection target region R ₁ that is set on the inner surface 20A of the container 20 positive. Lens is intended for forming an image of an examination target region R ₁ to the imaging camera, by using a wide-angle lens, it is possible to shoot in one wide range. Moreover, the filter transmits the wavelength of the light of the fluorescence emission component emitted from the foreign material X while attenuating the wavelength of the light emitted from the light source 11. As the filter, a transparent material or a lens whose surface is coated can be used. During photographing, the opening 21 of the container 20 is closed with a lid so that extra light does not enter the container 20 from the outside. Alternatively, the inspection area and the entire apparatus may be shielded from light with a cover or the like.

  For example, when a foreign substance X to be detected emits fluorescence in a range of 500 to 600 nm when irradiated with excitation light of 300 to 400 nm, a CCD having sensitivity to light with a wavelength of 300 to 1000 nm as an imaging device Or CMOS. As the filter, a so-called band-pass filter that passes light having a wavelength of 500 to 600 nm and attenuates light having a wavelength in other bands is used. Alternatively, a so-called long pass filter that transmits light having a wavelength of 450 nm or more and attenuates light having a wavelength of 450 nm or less may be used.

The detection unit 13 detects the foreign matter X in the inspection target region R ₁ based on the image captured by the imaging unit 10. The detection unit 13 includes an image processing device and an execution program thereof, and inputs an image captured by the imaging unit 10 and performs predetermined image processing. Thereby, the adhesion position of the foreign material X adhering to the inner surface 20A of the container 20, the adhesion area of the foreign material X adhering to the inner surface 20A of the container 20, and the fluorescence brightness of the fluorescence emitted from the foreign material X are measured.

  The storage unit 15 stores relationship information obtained in advance for the relationship between the mass per unit area of the foreign matter X and the fluorescence brightness of the fluorescence emitted by the foreign matter X.

  The calculation unit 14 calculates the mass of the foreign matter X detected by the detection unit 13 based on the adhesion area and the fluorescence luminance of the foreign matter measured by the detection unit 13 based on the relationship information stored in the storage unit 15.

  It is preferable that the connecting member 12 that connects the light source 11 and the image pickup unit 10 has no sliding part. Or, even if there is a sliding part on the connecting member that connects the light source 11 and the imaging unit 10, the sliding part is covered with a dust prevention cover, or a dust prevention coating process is performed. It is preferable that the sliding part is not exposed. By doing so, the connection member which connects the light source 11 and the imaging part 10 can be arrange | positioned inside the container 20 in the state which does not have an exposed sliding part.

The inspection target region is not limited to the configuration in which one inner surface is photographed by one imaging unit 10, and a plurality of imaging units 10 may be arranged so that a plurality of inner surfaces can be photographed simultaneously. If the area of one inner surface is large and it is difficult to increase the resolution of the imaging camera, the inspection target region may be divided into several regions on one inner surface. In this case, as shown in FIG. 5, the positions of the light source 11 and the imaging unit 10 in the container 20 are changed manually or by using a positioning mechanism such as an actuator, so that the inspection target region R ₁ shown in FIG. A region to be inspected R ₂ different from the above is photographed. An inner surface different from the inner surface 20 </ b> A of the container 20 is attached to the inner surface of the container 20 by changing the positions and orientations of the light source 11 and the imaging unit 10 in the container 20 and photographing the divided inspection target regions. Foreign matter can be inspected.

  As mentioned above, although this invention was demonstrated by suitable embodiment, such description is not a limitation matter and of course various modifications are possible.

  For example, in the above embodiment, ultraviolet light is used as excitation light, but visible light may be used as excitation light as long as the foreign matter to be inspected emits fluorescence by visible light.

  Further, in the above embodiment, a fluorescence fluorescence image emitted by a foreign substance is captured by irradiation with excitation light, but even when the inspection object does not have fluorescence emission characteristics, by irradiation with light energy, The same effects as those of the present invention can be exhibited as long as energy is converted by the inspection object to release the emitted energy. For example, even with respect to an inspection object from which thermal energy is released by irradiating light energy, the inspection object of the present invention can be detected. In this case, for example, a thermopile or a thermocouple array can be used as a detection unit that detects thermal energy. Such an object to be inspected can include scratches, delamination, alteration, and the like generated on the inner surface in addition to foreign substances.

  The inspection apparatus includes a light source that irradiates light energy toward the inner surface of the container, a detection unit that detects emitted energy that has been converted into energy by the inspection object by irradiation of light energy, and is detected by the detection unit. And a test section for inspecting the state of the test object based on the release position of the released energy and the released energy.

  In the above-described embodiment, the mass per unit area (M / S) of the foreign matter and the fluorescence luminance Q are exemplified as a substantially linear relationship. However, the present invention is not limited to such a relationship, and may be a nonlinear relationship. Can be applied. As a means for associating, for example, an approximate expression (relational expression) is obtained from a plurality of data of the fluorescence luminance Q and the mass per unit area (M / S) of the foreign object. May be calculated from the adhesion area S of the foreign matter and the fluorescence luminance Q. Alternatively, the relationship between the fluorescence luminance Q and the mass per unit area (M / S) of the foreign matter is stored in the storage unit 15 as a lookup table, and the mass M of the foreign matter is calculated using this lookup table. Alternatively, it may be obtained from the adhesion area S of the foreign matter and the fluorescence luminance Q.

  Moreover, in the said embodiment, although the light source 11 and the imaging part 10 were arrange | positioned in the container 20, when inspecting the upper part of the inner surface 20A of the container 20, the light source 11 and the imaging part 10 are outside the container 20. May be placed. Alternatively, when detecting the bottom of the container 20 or the entire inner surface of the container 20, the light source 11 and the imaging unit 10 may be disposed above the container 20.

  In the above embodiment, the inner surface 20A of the container 20 is made of a material that does not emit fluorescence when irradiated with excitation light. However, the present invention is not limited to this, and a material that emits slight fluorescence when irradiated with excitation light. Even if it comprises, the effect of the present invention is exhibited. In addition, as for the foreign material, the effect of the present invention is more exhibited as the material emits more fluorescence when irradiated with excitation light.

1 Inspection device
10 Imaging unit
11 Light source 12 Connecting member 13 Detector
14 Calculation unit
15 Storage unit
20 Container (object with internal space)
20A inner surface 21 opening
30 samples
40 Measuring container

Claims (6)

An inspection method for inspecting foreign matter adhering to the inner surface of an object having an inner space,
And step (a) for irradiating excitation light from a light source toward an inner surface of the object,
A step (b) of photographing a fluorescent image of fluorescence emitted from the foreign substance by irradiation of the excitation light using an imaging unit ;
A step (c) of detecting a foreign matter attached to the inner surface of the object from a fluorescent image photographed by the imaging unit using a detection unit ;
At least the inner surface of the object is composed of a metallic material which does not emit fluorescence by irradiation of the excitation light,
The foreign substance comprises a material which emits fluorescence having a wavelength different from the excitation light by irradiation of the excitation light, the inspection method. An inspection device for inspecting foreign matter adhering to the inner surface of an object having an inner space,
A light source that emits excitation light toward the inner surface of the object;
An imaging unit that captures a fluorescent image of fluorescence emitted from the foreign material by irradiation of the excitation light;
A detection unit for detecting foreign matter attached to the inner surface of the object from a fluorescent image taken by the imaging unit;
At least the inner surface of the object is made of a material that does not emit fluorescence when irradiated with the excitation light,
The foreign matter includes a material that emits fluorescence when irradiated with the excitation light,
The detection unit is configured to determine, from a fluorescent image photographed by the imaging unit, an attachment position of a foreign matter attached to the inner surface of the object, an attachment area of the foreign matter attached to the inner surface of the object, and a fluorescence intensity of fluorescence emitted from the foreign matter. Each has a function to measure,
A storage unit storing relationship information obtained in advance for the relationship between the mass per unit area of the foreign material and the fluorescence brightness of the fluorescence emitted by the foreign material;
A calculation unit that calculates the mass of the foreign substance at the specific adhesion position measured by the detection unit from the adhesion area and the fluorescence luminance of the foreign substance measured by the detection unit based on the relationship information stored in the storage unit DOO further that features, inspection apparatus. The storage unit stores, for each foreign material of different materials, relationship information obtained in advance for the relationship between the mass per unit area of each foreign material and the fluorescence brightness of the fluorescence emitted by the foreign material,
The inspection apparatus according to claim 2, wherein in the calculation unit, the mass of the specific foreign object is calculated using relationship information for the specific foreign object stored in the storage unit. The inspection apparatus according to claim 2 , wherein the object having the inner space is a metal container. A production management method for a production line that manufactures a wide variety of drugs or foods by sharing the same container,
After the production of the previous lot of medicine or food is completed and before the next lot of medicine or food is produced, (A)
After the step (A), the step (B) of inspecting the residue of the medicine or food of the previous lot attached to the inner surface of the container,
The step (B)
Irradiating excitation light toward the inner surface of the container (B1);
Step (B2) of photographing a fluorescent image of fluorescence emitted from the residue by irradiation with the excitation light;
Steps of measuring the attachment position of the residue attached to the inner surface of the container, the adhesion area of the residue attached to the inner surface of the container, and the fluorescence intensity of the fluorescence emitted from the residue from the photographed fluorescence image ( B3)
The mass of the residue at the measured specific attachment position is related information indicating the relationship between the mass per unit area of the residue obtained in advance and the fluorescence luminance of the fluorescence emitted from the residue. And (B4) calculating from the adhesion area and fluorescence luminance of the residue based on
The production management method, wherein at least the inner surface of the container is made of a material that does not emit fluorescence when irradiated with the excitation light. In the step (B4), the sum total of the mass of the residue at each adhesion position is calculated,
The production management method according to claim 5 , further comprising a step (B5) of comparing the total mass of the residue with a preset reference value and determining whether or not the cleaning is good in the step (A).

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