JP6396218B2 - 同位体の比率をモニタリングすることによる、代謝経路の規則的な変動における変化の比率の検出 - Google Patents

同位体の比率をモニタリングすることによる、代謝経路の規則的な変動における変化の比率の検出 Download PDF

Info

Publication number
JP6396218B2
JP6396218B2 JP2014560911A JP2014560911A JP6396218B2 JP 6396218 B2 JP6396218 B2 JP 6396218B2 JP 2014560911 A JP2014560911 A JP 2014560911A JP 2014560911 A JP2014560911 A JP 2014560911A JP 6396218 B2 JP6396218 B2 JP 6396218B2
Authority
JP
Japan
Prior art keywords
isotope
period
individual
variation pattern
relative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2014560911A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015511009A (ja
Inventor
エグバルニア，ハミッド，アール．
クック，マーク，イー．
ポーター，ウォーレン，ポール
バッツ，ダニエル，エルマー
Original Assignee
ウィスコンシン アルムニ リサーチ ファンデイション
ウィスコンシン アルムニ リサーチ ファンデイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ウィスコンシン アルムニ リサーチ ファンデイション, ウィスコンシン アルムニ リサーチ ファンデイション filed Critical ウィスコンシン アルムニ リサーチ ファンデイション
Publication of JP2015511009A publication Critical patent/JP2015511009A/ja
Application granted granted Critical
Publication of JP6396218B2 publication Critical patent/JP6396218B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4845—Toxicology, e.g. by detection of alcohol, drug or toxic products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A61B5/0836—Measuring rate of CO2 production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2014560911A 2012-03-07 2013-01-07 同位体の比率をモニタリングすることによる、代謝経路の規則的な変動における変化の比率の検出 Active JP6396218B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/414,061 US8512676B1 (en) 2012-03-07 2012-03-07 Detection of rate changes in systematic oscillations of metabolic athways by monitoring isotope ratios
US13/414,061 2012-03-07
PCT/US2013/020496 WO2013133904A2 (en) 2012-03-07 2013-01-07 Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios

Publications (2)

Publication Number Publication Date
JP2015511009A JP2015511009A (ja) 2015-04-13
JP6396218B2 true JP6396218B2 (ja) 2018-09-26

Family

ID=47628440

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014560911A Active JP6396218B2 (ja) 2012-03-07 2013-01-07 同位体の比率をモニタリングすることによる、代謝経路の規則的な変動における変化の比率の検出

Country Status (8)

Country Link
US (1) US8512676B1 (https=)
EP (1) EP2839277A2 (https=)
JP (1) JP6396218B2 (https=)
CN (1) CN104272107B (https=)
AU (1) AU2013230841B2 (https=)
CA (1) CA2865492C (https=)
IN (1) IN2014DN07247A (https=)
WO (1) WO2013133904A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104458603A (zh) * 2013-09-23 2015-03-25 苏州青山生物科技有限公司 一种新型幽门螺杆菌检测方法、装置及其应用
US20150196248A1 (en) 2014-01-10 2015-07-16 The United States Of America, As Represented By The Secretary Of Agriculture Methods of determining energy balance using breath carbon isotope ratios
US12527820B2 (en) 2014-12-01 2026-01-20 Vector Vitale Ip Llc Pharmaceutical composition and method for suppressing degeneration
US10226484B2 (en) 2014-12-01 2019-03-12 Peter Y Novak Pharmaceutical composition for improving health, cure abnormalities and degenerative disease, achieve anti-aging effect of therapy and therapeutic effect on mammals and method thereof
US10165965B1 (en) 2015-10-22 2019-01-01 Roy Pinchot Noninvasive method for measuring lactic acid and detection of anaerobic exercise for evaluating fitness
CN105954504B (zh) * 2016-06-01 2018-10-26 苏州科技学院 快速酒精定性信号处理方法以及初测装置
US10183041B2 (en) 2017-04-12 2019-01-22 Vector Vitale Ip Llc Antibacterial composition and its use in treating bacterial infections
US11484610B2 (en) 2019-11-22 2022-11-01 Vector Vitale Ip Llc Method of treating melanoma
US11596650B2 (en) 2019-12-20 2023-03-07 Vector Vitale Ip Llc Composition and method for the treatment of type 2 diabetes
US10799530B1 (en) 2019-12-20 2020-10-13 Vector Vitale Ip Llc Composition and method for the prevention and treatment of obesity
US10933091B1 (en) 2019-12-20 2021-03-02 Vector Vitale Ip Llc Composition and method for the treatment of type I diabetes
JP7718650B2 (ja) * 2021-05-19 2025-08-05 国立大学法人東北大学 感染症のバイオマーカ

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912178A (en) * 1994-02-16 1999-06-15 Wisconsin Alumni Research Foundation Passive measurement of isotopes to monitor health
JPH1087512A (ja) * 1996-09-18 1998-04-07 Isao Nishi ▲１３▼ｃ標識尿素試薬によるリアルタイムヘリコバクターピロリ感染検査方法
US6609068B2 (en) * 2000-02-22 2003-08-19 Dow Global Technologies Inc. Personal computer breath analyzer for health-related behavior modification and method
GB0120027D0 (en) * 2001-08-16 2001-10-10 Isis Innovation Spectroscopic breath analysis
US8622920B2 (en) * 2005-11-11 2014-01-07 Exalenz Bioscience Ltd. Breath test device and method
US8512258B2 (en) * 2005-11-11 2013-08-20 Exalenz Bioscience Ltd. Breath test device and method
US7465276B2 (en) * 2005-11-30 2008-12-16 Wisconsin Alumni Research Foundation Identification of disease characteristics using isotope ratios in breath
CA2671122C (en) * 2006-12-18 2013-05-07 John Cormier Apparatus and method for rapid and accurate quantification of an unknown, complex mixture
US8026049B2 (en) * 2007-03-23 2011-09-27 Wisconsin Alumni Research Foundation Noninvasive measurement and identification of biomarkers in disease state
CA2715157C (en) * 2008-02-15 2015-05-12 The Science And Technology Facilities Council Infrared spectrometer
DE102009055321B4 (de) * 2009-12-24 2013-04-18 Humedics Gmbh Verfahren zur Bestimmung der Leberleistung eines Lebewesens mittels quantitativer Messung der Metabolisierung von Substraten

Also Published As

Publication number Publication date
US8512676B1 (en) 2013-08-20
AU2013230841A1 (en) 2014-09-11
CN104272107A (zh) 2015-01-07
AU2013230841B2 (en) 2018-09-27
US20130236925A1 (en) 2013-09-12
IN2014DN07247A (https=) 2015-04-24
EP2839277A2 (en) 2015-02-25
JP2015511009A (ja) 2015-04-13
CN104272107B (zh) 2017-05-17
WO2013133904A2 (en) 2013-09-12
CA2865492C (en) 2021-06-01
CA2865492A1 (en) 2013-09-12

Similar Documents

Publication Publication Date Title
JP6396218B2 (ja) 同位体の比率をモニタリングすることによる、代謝経路の規則的な変動における変化の比率の検出
Jin et al. Acoustic analysis of snoring in the diagnosis of obstructive sleep apnea syndrome: a call for more rigorous studies
US20110105856A1 (en) Diagnostic testing
US20130066224A1 (en) Identification Of Disease Characteristics Using Isotope Ratios In Breath
Mazzatenta et al. Real time analysis of volatile organic compounds (VOCs) in centenarians
Yamanashi et al. Bispectral EEG (BSEEG) quantifying neuro-inflammation in mice induced by systemic inflammation: a potential mouse model of delirium
Alivar et al. Smart bed based daytime behavior prediction in Children with autism spectrum disorder-A Pilot Study
JP2019039896A (ja) 疾病判定システム及びヘルスケアサービス提供システム
Mariani et al. Evaluation of an automated pipeline for large-scale EEG spectral analysis: the National Sleep Research Resource
Yamanashi et al. New cutoff scores for delirium screening tools to predict patient mortality
Ghani et al. The IOMT-Based Risk-Free Approach to Lung Disorders Detection from Exhaled Breath Examination
Gulshan et al. Automated prediction of diabetes mellitus using infrared thermal foot images: recurrent neural network approach
CN116942137A (zh) 口气诊断方法、装置、设备及介质
Tsai et al. Use of the electronic nose to screen for small airway dysfunction in schoolchildren
Sello et al. Respiratory sound analysis in healthy and pathological subjects: A wavelet approach
CN113851224B (zh) 一种用于ams风险评估的数字仿真器
Kazemi et al. Frequency analysis of capnogram signals to differentiate asthmatic and non-asthmatic conditions using radial basis function neural networks
Malikhah et al. A New Approach for Detection of Viral Respiratory Infections Using E-nose Through Sweat from Armpit with Fully Connected Deep Network
Biller et al. Breath profiles by electronic nose correlate with systemic markers but not ozone response
Ball et al. Changes in lung aeration and respiratory function after open abdominal surgery: A quantitative magnetic resonance imaging study
Hernandez-Silveira et al. Challenges and trade-offs involved in designing embedded algorithms for a low-power wearable wireless monitor
Sugiura et al. Dementia Scale Classification with Sequential Model from Sleep Activity Data
Alexie et al. Investigation on Properties of Capnogram: On Stationarity and Spectral Components of the Signal
US20240041383A1 (en) Devices, systems, and methods for quantifying neuro-inflammation
Bestes et al. BreathRight-AI: An Intelligent Breath Analyzer for Diabetic Risk Predicition, Monitoring, and Personalized Recommendations

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160105

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160105

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20161125

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161206

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170302

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170627

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170927

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180220

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180619

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20180620

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20180709

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180731

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180829

R150 Certificate of patent or registration of utility model

Ref document number: 6396218

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250